Description
Book SynopsisThere is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now.
Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This g
Trade Review"A first-rate method book...[The authors] are highly skilled scientists with many years of experience in epilepsy."
- Mannfred A. Hollinger, Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis
Table of ContentsElectroshock, Chemoconvulsants, The Kindling Model of Temporal Lobe Epilepsy, Rapid Kindling: Behavioral and Electrographic, Experimental Models of Status Epilepticus, Audiogenic Seizures in Mice and Rats, Models of Focal Epilepsy in Rodents, Evaluation of Associated Behavioral and Cognitive Deficits in Anticonvulsant Drug Testing, Gene Targeting Models of Epilepsy: Technical and Analytical Considerations, The Hippocampal Slice Preparation, Microdialysis Techniques for Epilepsy Research, Methodologies for Determining Rhythmic Expression of Seizures.
