Medical specialties, branches of medicine Books
Harvard University Press Neurons and Networks
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£67.16
Harvard School of Public Health RiskBenefit Analysis
Book SynopsisThe first edition of this book, published in 1982, was a pioneer in the development of logical, yet simple, analytic tools for discussion of the risks which we all face. This new edition, revised, expanded, and illustrated in detail, should be of value both to professionals in the field and to those who wish to understand these vital issues.Trade ReviewThis book provides a comprehensive and up-to-date analysis of the methodology for assessing and managing risks. Based on well-developed lectures given for many years at the Harvard Center for Risk Analysis and written by both an academic and a practitioner in this rapidly evolving field, it contains clear explanations, excellent examples, and duality figures and tables...The best yet on this topic. -- S. A. Batterman * Choice *
£18.86
Harvard University Press Storylines
Book SynopsisWhat do we mean when we refer to our “identity,” and how do we represent it in the stories we tell about our lives? Is “identity” a sustained private core, or does it change as circumstances and relationships shift? Mishler explores these questions through analyses of in-depth interviews with five craftartists.Trade ReviewStorylines is as much a narrative of Elliot Mishler’s love affair with the crafts and his own craft as a researcher in narratives of identity, as it is a richly textured account of the creative forces in the lives of the five craft artists he interviewed. On the basis of these interviews…[he] concludes that life narratives are not factual histories of the past but rather constructions that can only emerge in the dialogic process of talking about one’s life trajectory and personal identity to a participant listener… Mishler’s celebration of the craft artist and non-alienated labor is eloquently moral and well worth the effort… Expect to be alternately enchanted, challenged, bewildered, sometimes even disoriented and finally enlightened. -- Louise J. Kaplan * American Craft *In this case, the researcher’s affinity with the artists’ lives is clear and, to my mind, makes the work on theory more readable and more credible because it emerges from Mishler’s own story…ultimately, readers can learn more about difference from a researcher like Mishler, who has carved from more than a decade’s research an unusual book that is both personal and professional in scope, philosophy, and evidence. -- Claire Badaracco * Journal of Communication *In the last two decades, there has been a significant shift in the study of persons and social life, away from counted-data methods to a focus on the life-story or narrative. Much of this shift has been a result of Elliot Mishler’s pioneering contributions. In this newest book, Mishler explores the meaning of the ‘hand-made’ for artisans devoting their lives to crafts, and in the process, enlarges both theory and method of human science study. This is truly a fascinating, sophisticated, and important study and one unique in showing the significance of taking seriously a reflexive and dialogic perspective in the study of identity. -- Bertram J. Cohler, University of ChicagoTable of ContentsPreface 1. Studying the Lives and Work of Craftartists: Identity and Narrative 2. Sources and Routes: Variable Pathways in Identity Formation 3. Contingencies and Turning Points: Discontinuities in the Life Course 4. Tensions and Contradictions: Revisiting Claims for Coherence in Life Stories 5. Identities in/as Relationships within the Family and at Work 6. Narrative Studies of Identity: A Forward Look Notes References
£27.86
Harvard Center for Population and Development Studies AIDS in Nigeria
Book SynopsisWritten by many of Nigeria’s leading HIV experts, this book explores the dynamics of the country’s epidemic, analyzes prevention efforts, identifies crucial gaps, and formulates effective strategies for controlling the epidemic. Complementing the experts' words are the dramatic portraits of people whose lives have been forever transformed by AIDS.Trade ReviewAn effective response to Nigeria's AIDS epidemic, with analysis of prevention efforts and strategies for controlling the disease, is presented by some of the country's leading health experts. Their scholarship is complemented with courageous stories of people whose lives have been transformed by AIDS. -- Sandra L. Jamison * Black Issues Book Review *An extremely rich source of information on the AIDS epidemic as it begins to ravage one of the most populous countries on the African continent...The voluminous AIDS in Nigeria: A Nation on the Threshold provides a comprehensive overview of a single country, examining the dynamics of the epidemic through an analysis of prevention efforts, and offering valuable information to researchers and policymakers...AIDS in Nigeria: A Nation on the Threshold is a treasure trove of information on the nature of an epidemic and how to deal with it in Nigeria...[It] should prove useful for both policymakers, politicians, academics, and the wider lay community. -- Ezekiel Kalipeni and Richard O. Djukpen * African Studies Review *
£23.36
Harvard University Press Crosssectional Atlas of the Brain and DVD
Book SynopsisThis book provides a set of high-resolution color cross-sections of the human brain. Each image is accompanied by state-of-the-art MRI and CT scans of the same specimen. The more than two hundred detailed and fully annotated images in this atlas provide a complete body of reference to the gross anatomy of the brain.Table of ContentsPreface Materials and Methods Acknowledgments Cross-sectional Atlas of the Brain Envoi Index
£95.16
Harvard University Press The Sensory Hand Neural Mechanisms of Somatic
Book SynopsisVernon Mountcastle has devoted his career to studying the neurophysiology of sensation in the hand. In The Sensory Hand he provides an astonishingly comprehensive account of the neural underpinnings of the rich and complex tactile experiences evoked by stimulation of the hand.Trade ReviewWhat is so special about primate hands? Few, if any, are more qualified to answer this question than Vernon Mountcastle. He and his colleagues have been the leading students of somatic sensibility (‘somesthesis’) in primates for over half a century. In The Sensory Hand, he offers an overview of a lifetime of influential, and sometimes controversial, research. The massive treatise begins with a review of the evolution and structure of the human hand. Mountcastle then ventures forth on a journey from manual behavior to tactile receptors all the way to the cerebral cortex. Through sixteen lengthy chapters, he reviews each level of the somatosensory pathway in rich detail… Mountcastle does a masterful job integrating the basics of what we know about how sensory information travels from the hand to the highest regions of the brain. Although there are a few excellent books on the evolution of the hands and how we use them, this is the only sophisticated book on the neural basis of how the hand works. -- Charles G. Gross and Asif A. Ghazanfar * Science *This volume will certainly become a definitive reference on the mechanisms of sensory processing in the hand… [It] will be essential for experts on the hand or somatosensory processing, an interesting read for scientists focused on sensation more generally, and a useful reference for graduate and undergraduate students early in their career. -- David J. Pinto * Quarterly Review of Biology *Table of Contents1. Perception and the World of Somesthesis 2. The Evolution and Structure of the Hand 3. General Features of Somatic Afferent Systems 4. Sensory Innervation of the Primate Hand 5. Large-Fibered Peripheral Interface 6. Dorsal Systems and the Dorsal Column Nuclear Complex 7. Small-Fibered Peripheral Interface 8. Ascending Spinal Cord Systems of Intrinsic Origin 9. Dual Functions of the Dorsal Thalamus 10. Postcentral Somatic Sensory Areas in Primates 11. Dynamic Neural Operations in Somatic Sensibility 12. Dynamic Neural Operations the Sense of Flutter Vibration 13. Parietal Lateral System and Somatic Sensibility 14. Parietal Frontal Sensory Motor Transition 15. Adaptive Reorganizations of Central Somatic Sensory Networks 16. Haptic Sense As Substitute for Vision
£88.76
Harvard University Press The Health Care Mess
Book SynopsisRichmond and Fein recount the fraught history of health care in America since the 1960s. As a new crisis looms, and the existing patchwork of insurance is poised to unravel, American leaders must again take up the question of health care. This book brings the voice of reason and the promise of compromise to that debate.Trade ReviewIn this authoritative and thoughtful book you will find what we need to know if we are to do anything about health care in America. -- Daniel Schorr, Senior News Analyst, National Public Radio, and author of Don't Get Sick in America!From their vast experience as both policymakers and respected scholars, Richmond and Fein have produced an authoritative account of the circumstances that created our present predicament and, more important, a thoughtful roadmap for how we can extricate ourselves from the quagmire. Their message is both practical and hopeful: the future of health care in this country is not 'preordained' by past decisions but will emerge from the choices still to be made. Their abiding optimism is both refreshing and timely. -- Jordan J. Cohen, M.D., President, Association of American Medical CollegesThe book is a tour de force, a cogent, comprehensive and deeply informed review of the condition of the American health care system. Highly readable and carefully referenced, it is a guided tour over the very complex terrain of American health care, including the complexities and disparities that make its potential benefits unavailable to so many and so expensive to all. The authors' plan for universally available health care offers a basis for a renewed national debate around the ideal of equity and justice in our health care system. This wonderful book should be read by everyone interested in better health for the American population. -- Jeremiah A. Barondess, M.D., President, The New York Academy of MedicineTwo of the giants of American medicine, public policy, and health policy have combined to produce a masterpiece detailing how our healthcare system came to be what it is, and how we can take it to the next level--providing quality care and access for all. It is must reading for students of medicine, public health and health policy. -- David Satcher, 16th US Surgeon General and Assistant Secretary for HealthRashi Fein and Julius Richmond bring a wealth of knowledge, long practical experience, and a welcome historical perspective to this excellent volume on the many aspects and causes of the steadily worsening health care crisis facing the nation. It's a continuing outrage that in today's America, the best and the worst in health care have existed side-by-side for so long in countless communities across the country. In this extraordinary era of nearly miracle-a-day new medical breakthroughs to prevent, treat, and even cure disease, inaction is unacceptable in the face of vast numbers of Americans with no health insurance, soaring inflation in the cost of health care, huge profits for the health insurance and pharmaceutical industries, and the very real danger of terrorist attacks with biological weapons. Genuine health reform is more urgent than ever, and the impressive recommendations of Fein and Richmond give us timely and important ideas about the direction such reform should take. Other modern nations have met and mastered this challenge, and America can too. -- Senator Edward M. KennedyWe spend far more than any industrialized country on health care and get far less for it. How did we get here? Former surgeon general Richmond and medical economist Fein offer a judicious account...Bringing to this...important subject authoritative knowledge and insight, the authors slice through the intricacies like an experienced surgeon. * Publishers Weekly *What sets Julius Richmond and Rashi Fein's The Health Care Mess apart from the pack is its expanded perspective. Rather than approaching health as a purely political issue, they detail the evolution of the health-care industry, especially the research sector, teaching infrastructure, and hubs of care delivery. For them, health care is a story not merely of failed political machinations but of new medicines and more advanced treatments. As both were involved in government efforts to expand care during the 1960s and 70s, they're particularly strong when discussing the 'bumper crop' of transformative health legislation and failed efforts to achieve universal coverage during that period. -- Ezra Klein * American Prospect *Over the course of their distinguished careers, the authors have participated in innumerable debates on matters of health care policy, large and small. They are veterans of fights over covering the uninsured, physician training, mental health, and substance abuse, and over funding for research, patient care, and medical education. They have extensive experience with the behavior of federal and state agencies, academic medical centers, insurers, and bureaucrats and bureaucracies, along with deep knowledge of the varying ways in which the United States has financed and delivered health care services. This book distills these experiences into a sophisticated historical and institutional perspective on why our health care system looks the way it does...The book is worth reading for the authors' perspective on how we ended up where we are and on ways and means of getting somewhere else. -- David A. Hyman * New England Journal of Medicine *Table of ContentsForeword by Jimmy Carter Introduction Part I. The Early Years (1900-1965) 1. The Educational and Scientific Revolution: Higher Standards and Changing Priorities 2. The Consumer Revolution: Increasing Access to Medical Care Part II. In the Wake of Medicare and Medicaid (1965-1985) 3. Emerging Tensions between Regulation and Market Forces: Dealing with Growth 4. Education for the Health Professions: The Impact of Growth Part III. Moving to the Present (1985-2005) 5. The Entrepreneurial Revolution: A Changing Face for Medicine 6. Beyond the Dollars: Progress in Health and the Role of Public Health Part IV. Anticipating the Next Revolution (2005 and Beyond) 7. Medical Challenges and Opportunities 8. Increasing Equity: Achieving Universal Health Insurance Notes Index
£24.26
Harvard University Press Spinal Cord Injury and the Family
Book SynopsisCombining clinical experience with patients’ own stories, the authors cover the causes of and prognosis for SCI through case studies, review common courses of rehabilitation, and answer the “what now?” questions—from daily routines to larger issues concerning sex, education and employment, childbearing, and parenting with SCI.Trade ReviewIn 2006, it was estimated that approximately 11,000 Americans sustained traumatic spinal-cord injuries (SCI) each year; that number is much higher now with injured soldiers returning from Iraq and Afghanistan. Physiatrist Alpert has compiled a timely and basic guide for SCI patients and their families, covering a multitude of important issues from basic spine anatomy, how injuries occur, and the impact of the injury's location to the first days after an injury, the emotional turmoil of the patient and family, and adjusting to work or school. Relationship issues, including dating, sex, fertility and pregnancy, and parenting, are painted in reassuring terms. Children with spinal cord injuries garner a separate chapter, as do the medical complications and challenges of SCI. This excellent overview with an emphasis on the physical effects of SCI will be invaluable to a growing, currently underserved audience. -- Janet M. Schneider * Library Journal (starred review) *Offers practical advice on dealing with the emotional turmoil that patients and families face as they make adjustments for work, school, dating, pregnancy, parenting, and other life events. This book is an invaluable resource for anyone touched by spinal cord injury. -- L. N. Massengale * Choice *Table of Contents* Foreword by Cindy and Ted Purcell * Abbreviations * Introduction to Spinal Cord Injury * Early Days: The ER, Rehab, and Beyond * Adjusting to SCI: The Return Home * Back to Productivity: Work, School, and Play * Dating after SCI: Out and About * Sexual Function after SCI: The Next Challenge * Couples and Relationship Issues: Making It Work * Fertility and Pregnancy: The Possibilities * Parenting with SCI: Moms and Dads on Wheels * Children and Adolescents with SCI: The Next Generation * Medical Complications of SCI: Do's and Don'ts * Appendix: Spinal Cord Injury by the Numbers * Resources * Suggested Reading * Acknowledgments * Index
£24.26
Harvard University Press Total Cure The Antidote to the Health Care Crisis
Book SynopsisGuaranteeing that all are insured does not create a system with the quality of care patients want, the flexibility clinicians need, and the internal dynamics for continual improvement of health care value. Luft presents a comprehensive new proposal, SecureChoice, which does all that while providing affordable health insurance for every American.Trade ReviewHal Luft's book deserves and will surely command a wide audience. Concerned public officials as well as concerned citizens will want to consider his comprehensive and detailed approach to ensuring access to quality medical care while controlling costs. -- Rashi Fein, coauthor of The Health Care Mess: How We Got into It and What It Will Take to Get OutThis book has some marvelous and novel ideas about how to restructure our health care system. -- Ezekiel J. Emanuel, author of Healthcare, Guaranteed: A Simple, Secure Solution for AmericaAn innovative, stimulating, well-written prescription for health care reform. -- Victor R. Fuchs, author of Who Shall Live? Health, Economics, and Social ChoiceIn America, we pay more than any other country does for health care that has inconsistent quality, leaves millions uninsured, and wastes billions of dollars on unnecessary care and administration. In Total Cure, Hal Luft recognizes that changing the payment system must be the foundation for any real health reform. -- Peter V. Lee, Executive Director, National Health Policy, Pacific Business Group on HealthLuft has written a sober, thoughtful volume...It may also prove very influential. -- David Gratzer * Forbes *Economist Harold Luft presents a thought-provoking and original proposal in Total Cure...Now is the time to evaluate SecureChoice and other health care proposals. Swift action is crucial if policymakers are to take advantage of this defining moment to enact health care reforms. -- Marian E. Gornick * New England Journal of Medicine *Of the numerous discussions of health care reform, many are longer on diagnosis than on prescription. Total Cure: The Antidote to the Health Care Crisis is a notable exception to that tendency. After presenting a brief overview of the state of U.S. health care, it turns quickly to developing an innovative reform proposal, and it does so in considerably greater depth than most similar books...SecureChoice is an ingenious, carefully constructed proposal...Some readers not versed in health policy may find Total Cure: The Antidote to the Health Care Crisis challenging. It rewards the effort, however, by providing both an important new health care reform option and an illuminating tutorial on the issues at stake. -- Samuel Y. Sessions * Journal of the American Medical Association *Total Cure in whole or in part should definitely be included in the syllabus of a course that addresses what we might do to reform the U.S. health care system. And for those who want to be challenged to think about how they would restructure our health care system, Total Cure is a great read--it makes you think hard. -- Katherine Swartz * Inquiry *Are you sitting down? I have in hand a 318-page health care reform plan that could actually work. Really. Harold Luft's Total Cure is a calm, fearless leap across the abyss of health policy cynicism and the greatest of improbabilities: a comprehensive, detailed, and practical CTRL-ALT-DEL for the U.S. health care system...Luft's Total Cure is just what the policy doctors on Capitol Hill will need: a wise, postpartisan, durable shop manual for how to make health reform actually happen in our time. -- J. D. Kleinke * Health Affairs *Brilliant and badly underappreciated...Luft seems to recognize that advances in medical technology make the traditional approach to private health insurance less viable. Yet he also sees the value in promoting constructive competition. Part of the appeal of Luft's approach is that it is very open-ended: While [Universal Coverage Pool] coverage for big-ticket costs is mandatory, wraparound coverage is optional. His plan could be financed through something like our current system of tax incentives for employers, or we could finance it through taxes. And though fairly complex in its details, the basic outlines are simple and attractive: With the UCP in place, no one will ever go bankrupt due to illness; private insurers and providers will compete on the basic of cost and quality; and the health system will get better and cheaper over time. -- Reihan Salam * Forbes.com *Table of Contents* Preface * List of Tables and Figures * List of Abbreviations * Introduction * Build on What You've Got, but Recognize Real-World Constraints * Overview of a Restructured Health Care System * Covering the Cost of Care: Rethinking Health Insurance * Organizing Care and Paying Providers * Choices: Harnessing Data to Inform Decisions * Financing SecureChoice * Malpractice, Pharmaceuticals, Medical Education, and Prevention * How SecureChoice Would Work for Patients and Physicians * Getting There: Policy Choices, Implementation, and Transition * Notes * Glossary * Index
£24.26
Harvard University Press Brain Storm
Book SynopsisFemale and male brains are different, thanks to hormones coursing through the brain before birth. This title argues passionately that the analysis of gender differences deserves far more rigorous, biologically sophisticated science.Trade ReviewI'm the ideal test reader for Brain Storm. I've always had reservations about the sweeping claims that there are fundamental differences in the organization of male and female brains, caused by prenatal hormones. But the sheer number of published studies that seemed to give incontrovertible evidence led me to assume that the theory was sound. This elegantly written and fascinating book has changed my mind. Jordan-Young's comprehensive analysis of the array of conflicting results and methodological weaknesses shows that we have closed the book on this topic far too soon. Her warning is one that all scientists can agree with: Careful! -- Lisa Diamond, author of Sexual FluidityThis important and intellectually powerful book shows that a dominant paradigm in human sex differences is held together by chewing gum. By painstakingly examining a large and contradictory literature, Jordan-Young shows the weakness of the brain organization hypothesis. She has so much respect for the scientific method that she can hope that reason and integrity will help create a better, more empirically sound theory of sex differences, and she reaches out to scientists to offer a glimpse of a new psychobiology. -- Anne Fausto-Sterling, author of Myths of GenderThis is a book of remarkable depth that sets a new standard for clear scientific thinking about complex behavioral traits, as well as for interdisciplinary scholarship. Rebecca Jordan-Young charts a fresh new course through the morass of questions about gender and sexuality with enviable humor, fairness, and intellectual power. -- Evan Balaban, McGill UniversityBrain Storm poses the most comprehensive challenge yet to the claim that prenatal hormone exposure permanently structures the brain to be either masculine or feminine, and does so in a highly engaging, fair-minded narrative that is a delight to read. -- Stephen J. Ceci and Wendy M. Williams, Cornell UniversityJordan-Young has written a stunning book that demolishes most of the science associated with the dominant paradigm of the development of sex and gender identity, behavior, and orientation. The current paradigm, brain organization theory, proposes: "Because of early exposure to different sex hormones, males and females have different brains"; and these hormones also create "gay" and "straight" brains. Jordan-Young interviewed virtually every major researcher in the field and reviewed hundreds of published scientific papers. Her conclusion: "Brain organization theory is little more than an elaboration of longstanding folk tales about antagonistic male and female essences and how they connect to antagonistic male and female natures." She explains, in exquisite detail, the flaws in the underlying science, from experimental designs that make no statistical sense to "conceptually sloppy" definitions of male and female sexuality, contradictory results, and the social construction of normality. Her conclusion that the patterns we see are far more complicated than previously believed and due to a wider range of variables will shake up the research community and alter public perception. * Publishers Weekly (starred review) *A carefully researched volume that exposes the problems with the widely accepted idea that gender differences are created by certain hormones in the womb. -- Alex Spanko * Boston Globe *What Jordan-Young's analysis uncovered is by turns fascinating and appalling...This book is not only a tonic, it's also full of scientific insights presented in plain, intelligent prose--an absorbing read, if you've ever wondered what was going on in the secret parts of your attic. -- Sara Lippincott * Los Angeles Times *It was with appreciation verging on glee that I read Barnard professor Rebecca Jordan-Young's devastatingly smart and definitive critique: Brain Storm: The Flaws in the Science of Sex Differences. Jordan-Young argues that the science of prenatal hormones, gender, and the mind "better resembles a hodgepodge pile than a solid structure." And she knows of what she speaks. An expert on measures and study designs, Jordan-Young has spent the last 13 years combing the literature on brain organization, unpacking assumptions, questioning methods and statistical practices, holding one paper up against another. She stresses that fetal hormones must matter to the brain--somehow. But after picking apart more than 400 studies that try to understand the genesis of particular psychological sex differences (real or supposed), she concludes that fetal T looks like an awfully anemic explanation...After decades of determined research, if robust links between prenatal hormones and "male" or "female" minds really exist, shouldn't we see those links across lots of different kinds of studies? This matters because the obsession with prenatal T can easily become a distraction. It can make us forget how much gender norms have changed--think of all those female accountants, lawyers, and doctors who weren't around 50 or even 30 years ago--and how remarkably similar men's and women's brains and minds actually are. All this unwarranted hammering away at difference (and its putative explanations) causes real trouble, too. As a growing body of research shows, cues that foreground gender and bring stereotypes to mind can dampen men's performance on tests of social sensitivity, women's scores on math tests, and women's stated interest in quantitative pursuits. Jordan-Young has done an enormous amount of work to untangle the gender claims. We ought to read her, cite her, thank her. And then, let's move on. -- Amanda Schaffer * Slate *Jordan-Young ferret[s] out exaggerated, unreplicated claims and other silliness regarding research on sex differences. The book [is] strongest in exposing research conclusions that are closer to fiction than science. -- Diane F. Halpern * Science *Exhaustively analyses every relevant study on hormonal sex differentiation of the human brain, and argues that they are riddled with weaknesses, inconsistencies and ambiguity. It's a clarion call for better science on the subject. -- Madeleine Bunting * The Guardian *In her exhaustive survey of the literature, Jordan-Young discovers a hodge-podge of tiny samples, inadequate controls, conflicting data and extravagant conclusions...By meticulously revealing the flawed research behind brain organization theory, she opens the way to a non-hierarchical study of sex difference that will be both more fruitful for science and less damaging for society. -- Hilary Rose and Steven Rose * London Review of Books *Jordan-Young's detailed and exhaustive critique of brain organization research is quite welcome. -- Vernon Rosario * Gay and Lesbian Review *
£24.26
Harvard University Press Health and Human Rights
Book SynopsisHealth and Human Rights: Basic International Documents assembles in one book the basic instruments of international law and policy that express the values of human rights for advancing health. Topics include ethics; biotechnology; right to health; freedom from torture; women and reproductive health; children; right to a clean environment; and more.
£22.46
Harvard University Press Cerebral Dominance The Biological Foundations
Book SynopsisAlthough cerebral dominance was discovered in the 1860s, almost nothing was known for many years about its biological foundations, the study of which has undergone a revolution in the past decade and a half. Geschwind and Galaburda have assembled a distinguished group of investigators, each a pioneer in some aspect of the biology of dominance.Trade ReviewWell written, conveys a wealth of information in a few hundred pages, and is obviously stimulating. It provides a new perspective for ophthalmic and neurophthalmic investigators and, like any truly new perspective, it comes from an unexpected direction. Geschwind…has left us a rich legacy of which this book is only a part. -- Simmons J. Lessell * Archives of Opthalmology *Clearly written and engaging accounts of state-of-the-art research on relatively precise topics… The result is a stimulating insight into the current status and possible future potential of a burgeoning area of neuroscience. -- J. Graham Beaumont * Biological Psychology *This book is exacting. It requires to be read, not skimmed. The text is conceptually stimulating… Geschwind was undoubtedly one of the most scholarly and creative behavioural neurologists of our epoch. Above all, he was a catalyst. This book should trigger further conceptual and technical advances in the field. -- Freda Newcombe * Quarterly Journal of Experimental Psychology *Filled with contributions from investigators working at the forefront of knowledge… The chapters are well-written, integrative, state-of-the-art reports. -- Sally P. Springer * Quarterly Review of Biology *This is an exciting collection…that presents a sizeable quantity of background information for this relatively new field of biological investigation… As a guidebook and reference source for future research, this volume may prove invaluable. -- D. Frank Benson * Trends in Neurosciences *Table of Contents1. Historical Introduction Norman Geschwind Part One Brain Asymmetry in Humans 2. Anatomical Asymmetries Albert M. Galaburda 3. Radiological, Developmental, and Fossil Asymmetries Marjorie LeMay 4. A Dendritic Correlate of Human Speech Arnold B. Scheibel 5. Brain Electrical Activity Mapping Frank H. Duffy, Gloria B. McAnulty, and Steven C. Schachter 6. Asymmetrical Lesions in Dyslexia Thomas L. Kemper Part Two Brain Asymmetry in Other Species 7. Learning, Forgetting, and Brain Repair Fernando Nottebohm 8. Behavioral Asymmetry Victor H. Denenberg 9. Age, Sex, and Environmental Influences Marian Cleeves Diamond 10 Functional and Neurochemical Asymmetries Stanley D. Glick and Raymond M. Shapiro 11 Lateralization of Neuroendocrine Control Ida Gerendai 12 Experimental Modification of Gyral Patterns Patricia S. Goldman-Rakic and Pasko Rakic Part Three Biological Associations of Laterality 13 Twinning, Handedness, and the Biology of Symmetry Charles E. Boklage 14 Laterality, Hormones, and Immunity Norman Geschwind and Peter O. Behan Contributors Index
£32.26
Harvard University Press Particles in Our Air
Book SynopsisGenerated by the use of fossil energy, respirable-sized particles pose a major threat to our environment and health. In this book the hypothesis that fossil fuels are the primary culprit is examined in detail, including the nature, generation, and transport of particulate air pollution.Trade ReviewThis edited volume on the health effects of air contaminants reflects the combined wisdom of twelve prominent academics...For those involved in air quality research or management, or for those teaching air quality measurement in the classroom, this is an essential book...It is a good high-level textbook, inexpensive and well-presented. -- Dona Schneider * The Environmentalist [UK] *Provides the best scientific attempt to estimate the level of fine particle exposure indoors, based on their outdoor concentration. However, these authors agree that fixed monitoring stations are poor surrogates for exposure to people...[Particles in Our Air] must be considered one of the clearest descriptions of scientific aspects of particles in air. Although the authors represent a specific scientific point of view, they are clearly leaders in their respective fields. This book is highly recommended. -- A. Alan Moghissi, Editor-in-Chief * Environment International *By controlling emissions and by dispensing pollutants, we have reduced their concentration. However, expanding population and energy demands have ensured that air pollution remains one of the most important environmental challenges faced by mankind. Drs. Spengler and Wilson have performed a unique service by bringing together in a most coherent way the thoughts of the most prominent researchers in this field. It gives context to today's concerns as we worry about "how far to go?" for particulate matter, ozone, SOx, NOx, VOCs and more. It's a must read not only for practitioners, regulators, the regulated and legislators, but for "students" of all inclinations who want to learn more about this fascinating field. -- The Honorable Don Ritter, Chairman, National Environmental Policy Institute, Former CongressmanLong before the publication of this invaluable volume, Richard Wilson and John Spengler were among the leaders in drawing constructive worldwide attention to the health effects of minute airborne particles. This volume confirms my earlier view that we have no better teachers on this crucial issue. They have produced a timely, compelling and lucid treatment of a public-health challenge that urgently merits everyone's attention. -- Ralph Cavanagh, Energy Program Director for the Natural Resources, Defense Council, and Visiting Professor, Stanford Law SchoolWritten by the leading scholars, this book is a masterful summary of the scientific literature on the health effects of air pollution. It explores what is known, what is controversial, and the scientific basis for the health effects, including lessons from animal and clinical studies. The book begins and ends with the public policy issues, building the case for more stringent control of air pollutants. -- Professor Lester Lave, Carnegie Mellon UniversityParticles in Our Air provides a timely and authoritative discussion of what is potentially the most serious pollution problem confronting us at the close of the twentieth century. The book discusses in detail the types, source, characterization, and measurement of airborne particles, the evidence linking such particles to the causation of various diseases, and the implications of data suggesting that existing concentrations of the particles may cause up to 60,000 deaths per year in the U.S. In view of the growing national and international concern about the impacts of airborne particles on human health, this volume should be of interest to a wide readership and should constitute an invaluable source book for health professionals, environmentalists, and others working in the field. -- Dr. Arthur C. Upton, Environmental and Occupational Health Sciences Center, Formerly Director, National Cancer Institute
£16.16
Harvard University Press In Support of Families
Book SynopsisThis book examines the effects of stress on children and parents and explores strategies for coping. The authors view the family as a dynamic system whose health is vitally related to internal relationships and interactions with other social networks. Stress in this context can be a positive or a negative influence on family health.Trade ReviewThrough poignant case histories, reviews of research, and policy analyses, the book demonstrates how support from all systems—educational, health care, and governmental—is vital to families… The strength of this book lies in its discussion of social policy, its well-defined approach to problems, and its delineation of successful factors in programs that have provided support for families and children. It is an invaluable resource for physicians, therapists, educators, and social workers interested in policy changes to help families. * New England Journal of Medicine *Offers a multidimensional survey of ways in which individual and family units cope with stress. The fifteen essays…present fresh slants on such subjects as single mothers, family life and corporate policies, teenage pregnancy, and education of families for parenting. Although targeted for therapists and specialists in family service agencies, this is also a helpful resource for laypersons interested in the changing status of families. * Cultural Information Service *This book examines the impact of stress on the family and offers a new perspective on methods of coping… In Support of Families lives up to its title and is highly recommended for all professionals who work with individuals as well as with families. The family systems model provides a clear and pragmatic focus, and it is refreshing to see the strengths and resiliencies in families emphasized. * Hospital and Community Psychiatry *This readable and significant book should be of wide appeal to mental health professionals; one hopes that its message will also reach policy makers. * Readings *This timely and integrated anthology of papers from the field gives a humanistic and scholarly approach to the subject… Sensitive and insightful. * Yale Scientific *Recommended as an excellent sourcebook for those interested in long-term coping strategies. -- J. S. McCrary * Choice *Table of ContentsIntroduction: The Family, Stressed yet Protected Michael Y. Yogman and T. Berry Brazelton I. Theoretical Overview: Stress and Coping in the Family System 1. Family Systems: Understanding the Family through Its Response to Chronic Illness David Reiss 2. Stress on and in the Family Jerome Kagan 3. A Developmental Perspective on Psychosocial Stress in Childhood Felton Earls II. Forces Within the Family: New Roles 4. Fathers: An Intrafamilial Perspective Ross D. Parke 5. Single Mothers and Joint Custody: Common Ground Richard N. Atkins III. Forces Outside the Family: Work and Family Life 6. Working It Out: Effects of Work on Parents and Children Ann C. Crouter and Maureen Perry-Jenkins 7. Family Life and Corporate Policies Ellen Galinsky 8. Utilitarianism in the Regulation of Corporate and Family Life Abraham Zaleznik 9. Supplemental Care for Young Children Gwen C. Morgan IV. Special Stresses 10. Family Adaptation to Divorce Kathleen A. Camara 11. The Family and Chronic Illness in Children John M. Leventhal and Barbara F. Sabbeth 12. Teenage Pregnancy Lorraine V. Klerman V. Policy Implications 13. Education of Families for Parenting Bettye M. Caldwell 14. The Social-Policy Context for Families Today Lisbeth B. Schorr, C. Arden Miller, and Amy Fine References Acknowledgments Index
£60.31
Harvard University Press In Support of Families
Book SynopsisThis book examines the effects of stress on children and parents and explores strategies for coping. The authors view the family as a dynamic system whose health is vitally related to internal relationships and interactions with other social networks. Stress in this context can be a positive or a negative influence on family health.Trade ReviewThrough poignant case histories, reviews of research, and policy analyses, the book demonstrates how support from all systems—educational, health care, and governmental—is vital to families… The strength of this book lies in its discussion of social policy, its well-defined approach to problems, and its delineation of successful factors in programs that have provided support for families and children. It is an invaluable resource for physicians, therapists, educators, and social workers interested in policy changes to help families. * New England Journal of Medicine *Offers a multidimensional survey of ways in which individual and family units cope with stress. The fifteen essays…present fresh slants on such subjects as single mothers, family life and corporate policies, teenage pregnancy, and education of families for parenting. Although targeted for therapists and specialists in family service agencies, this is also a helpful resource for laypersons interested in the changing status of families. * Cultural Information Service *This book examines the impact of stress on the family and offers a new perspective on methods of coping… In Support of Families lives up to its title and is highly recommended for all professionals who work with individuals as well as with families. The family systems model provides a clear and pragmatic focus, and it is refreshing to see the strengths and resiliencies in families emphasized. * Hospital and Community Psychiatry *This readable and significant book should be of wide appeal to mental health professionals; one hopes that its message will also reach policy makers. * Readings *This timely and integrated anthology of papers from the field gives a humanistic and scholarly approach to the subject… Sensitive and insightful. * Yale Scientific *Recommended as an excellent sourcebook for those interested in long-term coping strategies. -- J. S. McCrary * Choice *Table of ContentsIntroduction: The Family, Stressed yet Protected Michael Y. Yogman and T. Berry Brazelton I. Theoretical Overview: Stress and Coping in the Family System 1. Family Systems: Understanding the Family through Its Response to Chronic Illness David Reiss 2. Stress on and in the Family Jerome Kagan 3. A Developmental Perspective on Psychosocial Stress in Childhood Felton Earls II. Forces Within the Family: New Roles 4. Fathers: An Intrafamilial Perspective Ross D. Parke 5. Single Mothers and Joint Custody: Common Ground Richard N. Atkins III. Forces Outside the Family: Work and Family Life 6. Working It Out: Effects of Work on Parents and Children Ann C. Crouter and Maureen Perry-Jenkins 7. Family Life and Corporate Policies Ellen Galinsky 8. Utilitarianism in the Regulation of Corporate and Family Life Abraham Zaleznik 9. Supplemental Care for Young Children Gwen C. Morgan IV. Special Stresses 10. Family Adaptation to Divorce Kathleen A. Camara 11. The Family and Chronic Illness in Children John M. Leventhal and Barbara F. Sabbeth 12. Teenage Pregnancy Lorraine V. Klerman V. Policy Implications 13. Education of Families for Parenting Bettye M. Caldwell 14. The Social-Policy Context for Families Today Lisbeth B. Schorr, C. Arden Miller, and Amy Fine References Acknowledgments Index
£30.56
Harvard University Press Fixing Medical Prices
Book SynopsisMiriam Laugesen goes to the heart of U.S. medical pricing: to a largely unknown committee of organizations affiliated with the American Medical Association. Medicare’s ready acceptance of this committee’s advisory recommendations sets off a chain reaction across the American health care system, leading to high—and disproportionate—rate setting.Trade ReviewIn Fixing Medical Prices: How Physicians Are Paid, Miriam Laugesen opens the ‘black box’ of policy choices embedded in the nation’s health financing system. Her thorough analysis of physician pricing exposes how seemingly technical decisions on physician prices are actually highly political—riddled with conflicts of interest and largely immune from public accountability. Policymakers and the public owe Miriam Laugesen a debt of gratitude for shining a light on fundamental policy flaws. We now have no excuse for failing to correct them. -- Judith Feder, Georgetown UniversityOur medical prices are too high. Moreover, these prices are grossly misaligned with what Americans really need. Warped prices reflect the arcane political economy of our $3 trillion medical system. In this beautiful book, Miriam Laugesen combines the rigor of political science with the granular knowledge of health services research to illuminate these pathologies. Most importantly, she provides a road map to do better. This is an important book. -- Harold Pollack, University of ChicagoCombining interviews, thoughtful historical perspective, and statistical analysis, Miriam Laugesen offers the best study yet on the politics of physician payment in the United States. A weak administrative apparatus in Washington makes the power of the House of Medicine all the more formidable. The results of that process—including the power of specialty doctors and the weakness of primary care providers—should interest and trouble us all. -- Daniel Carpenter, Harvard UniversityWill people still care about these issues for the next four years? I hope so, because this is the best book I know of on Medicare pricing and its influence on pricing throughout the broader U.S. health care system. -- Tyler Cowen * Marginal Revolution *In Fixing Medical Prices, Miriam Laugesen takes a deep dive into the weeds of U.S. medical pricing policy to uncover problems with how Medicare sets physician payments. -- Kathleen M. Haddad * Health Affairs *Fixing Medical Prices is a superb book on a subject—how Medicare determines what it pays physicians—that is both exceedingly complex and arcane, yet also critically important in terms of impacting the structure of health care finance, organization and delivery…The book should be required reading for health policy scholars, medical students, medical historians, and anyone interested in how money—in the form of Medicare payment policy—shapes U.S. health care. -- Rick Mayes * Bulletin of the History of Medicine *
£32.36
Harvard University Press Freud
Book SynopsisÉlisabeth Roudinesco's bold reinterpretation of Sigmund Freud is a biography for the twenty-first centurya sympathetic yet impartial appraisal of a genius admired but misunderstood in his time and ours. Alert to tensions in his character and thought, she views Freud less as a scientific thinker than as an interpreter of civilization and culture.Trade ReviewDo we think we know all there is to know about Freud? Not even close. Élisabeth Roudinesco’s book is full of fresh facts about Freud’s life and potent interpretation of his work. A sparkling and highly original intellectual biography. -- Mark Edmundson, author of The Death of Sigmund Freud: The Legacy of His Last DaysThrough seamlessly and eloquently weaving together details from Freud’s time and our own, [Roudinesco] provides a refreshingly new and welcome account—warts and all. -- Janet Sayers * Times Higher Education *[Roudinesco] provides an insightful, balanced, and sympathetic portrait of Freud. As she assesses Freud’s revolutionary ideas about rationality, sexuality, and the unconscious, Roudinesco demonstrates that Freud was less a scientific thinker who uncovered universal truths than a product of his time: a genius, to be sure, but very much a bourgeois shaped by society, family, and politics in the late 19th century…Her critique has an especially persuasive force because it is grounded not only in an analysis of Freud’s books, diaries, and letters but from accounts of his sessions with patients. -- Glenn C. Altschuler * Psychology Today *What makes Freud: In His Time And Ours…such a captivating read, is the author’s ability to explain what are often complex, deeply-layered, and dark taboo subjects, into a language that is easily understood…[A] brilliant biography. -- J. P. O’Mallery * Irish Examiner *Élisabeth Roudinesco’s new biography, Freud: In His Time and Ours, is a welcome reminder of Freud’s considerable influence on 20th-century intellectual life. More important, she puts center stage Freud’s complex brand of rationalism and the full scope of his achievements, which went far beyond offering a cure for individuals. In particular, Roudinesco captures Freud’s recognition of the insurmountable ways in which our irrational desires and longings shape who we are and how we act. This correction is needed not only to give us a more accurate sense of Freud’s innovations, but also to contrast it against today’s more complacent assumptions about human rationality. Despite what economists and psychologists and political scientists insist, the rational self is not always master in its own house—whether in individual life or in collective experience…Roudinesco recounts Freud’s life and the development of his thought with great flair. -- Samuel Moyn * The Nation *Freud, a pioneer in creative biography, meets his analyst, a woman who illuminates modern psychology and social evolution for general audiences. This is perhaps the most important Freud biography since that of Jones, and a welcome corrective. -- E. James Lieberman * Library Journal (starred review) *A new standard…[A] masterful achievement…It has the…tangible mix of insouciance, scholarly thoroughness and psychoanalytic acumen, and it demonstrates Roudinesco’s critical and philosophical talent. The book’s strength is not so much in providing new material, although it does supply intriguing details about Freud’s patients and his relationships with family, friends, opponents and disciples. Rather, Roudinesco offers us a rereading of Freud that makes sense of him in relation to his emergence in the Jewish Vienna of the second half of the 19th century, and to the ‘old Europe’ to which he was so attached until it crumbled in the 20th. -- Stephen Frosh * Jewish Chronicle *[A] compelling biography…Forget the science: Roudinesco presents a brilliant cultural commentator, a man who married Romanticism and science in a way attractive to the belle époque. In fact, the biographer anchors Freud to his time and place in a way he himself—for all his focus on ‘civilization and its discontents’—never managed. -- Brian Bethune * Maclean’s *This is a book which eschews simple answers and is thus a significant milestone in our understanding of Freud… Roudinesco’s work is both comprehensive and subtle… In reclaiming [Freud] as ‘the master interpreter of civilization and culture,’ she has provided an invaluable service. -- Stuart Kelly * Scotland on Sunday *A revealing portrait of a cultural revolutionary. -- Bryce Christensen * Booklist (starred review) *A balanced account of one of the most exceptional and daring thinkers and writers to emerge in the modernist era. -- J.P. O’Malley * Irish Times *
£32.36
Harvard University Press Population Policies Reconsidered
Book SynopsisPopulation Policies Reconsidered brings together a rare combination of scholars, feminists, social activists, and policy-makers across many disciplines to critically reexamine the scientific foundation of contemporary population policies, exploring dilemmas from the perspective of ethics, women's empowerment and health, and human rights.
£14.20
Harvard University Press Power and Decision
Book SynopsisThis volume brings together feminist social and biomedical scholars from the Southern and Northern hemispheres to examine the aggregate forces that affect reproductive choice.Trade ReviewMany of these writers discuss phenomena that, if taken seriously by demographers, would have important influence in their approach to research and policy… They raise the issue of whether women really have choice in reproductive decisions or in family planning method given existing social, especially gender, inequalities and the hegemony of the population control movement. -- Nancy E. Riley * Signs *
£14.20
Harvard University Press Social Neuroscience
Book SynopsisHuman beings evolved in the company of others. Mutually reinforcing connections between brains, minds, and societies have profound implications for physical and emotional health. Social Neuroscience offers a comprehensive new framework for studying human brain development and human behavior in their social context.Trade ReviewThis first-class synthesis of the latest research in neurobiology, sociology, and psychiatry/psychology will be of the greatest interest to both pure scientists and practical clinicians. A new field is being born. Don’t miss it! -- Robert Rosenheck, Professor of Psychiatry and of Public Health, Yale School of MedicineA valuable contribution to this new and exciting field, with implications for potentially new solutions to age-old problems of human nature. -- A. Olivera * Choice *
£43.31
John Wiley & Sons Inc Pharmacology of the Critically Ill
Book SynopsisFocuses on the drugs used to treat the illness or injury in intensive care. This book addresses the other issue for those caring for the critically ill - how organ function will affect the drugs used, and how to adapt management accordingly. It includes principles of pharmacology; absorption, transport, and elimination of drugs.Table of ContentsContributors. Preface. Part 1: Basic Pharmacology. Pharmacokinetics and Pharmacodynamics. Drug Action. Renal Failure. Hepatic Failure. Heart Failure. Gut failure. Brain failure. Respitatory Failure. Children. Safe Drug Prescribing in the Critically Ill. Index.
£64.76
John Wiley & Sons Inc Respiratory Support in Intensive Care
Book SynopsisA guide to the methods used to provide respiratory support in the patient with respiratory failure. It outlines the evolution of different techniques, explains the physiological principles, and evaluates their role in clinical practice. It also includes information on the increasing use of non-invasive techniques.Table of ContentsPreface to first edition. Preface to second edition. Conversion factors, respiratory, and abbreviations used in text. 1.Development of techniques of respiratory support. 2.Physiological background to mechanical ventilation. 3.Mechanical basis of respiratory support. 4.Methods of providing respiratory support. 5.Barotrauma: techniques for reducing peak airway pressure. 6.Modern ventilator technology. 7.Respiratory failure: conservative treatment and indications for providing respiratory support. 8.Selection and care of artificial airways. 9.Care of the patient during respiratory support. 10.Modern ventilator technology. Appendix 1: Suppliers of respiratory support equipment. Index
£73.76
John Wiley and Sons Ltd Kleinians Psychoanalysis Inside Out
Book SynopsisA Melanie Klein and her followers caused a revolution in psychology; this is the first book to bring together and describe their pioneering work. A The book is a highly engaging read, combining lively biographical sketches with psychoanalytic theory and patient case studies.Trade Review'This is an astonishing compilation of biographical and professional details about Melanie Klein and nine of her followers. Many are of such recent history that these are uniquely valuable accounts. They give a clear picture of a remarkable group of contemporary psychoanalysts whose influence since the Second World War has been gaining ground steadily within the international psychoanalytic movement and in other academic and professional disciplines. The group is remarkable, and this book is a remarkable celebration of them.' Bob Hinshelwood, Professor of Psychoanalysis and author of Dictionary of Kleinian Thought and Melanie Klein for Beginners 'This book is a celebration of people who have advanced our understanding of the factors that shape our everyday lives. There are many anecdotes about them here that are quite fascinating.' Australian Journal of PsychotherapyTable of ContentsAcknowledgements. Illustrations. Introduction: Inside Out. Chapter 1: Melanie Klein: Discovering Inner Reality. Chapter 2: Susan Isaacs: Children's Phantasies. Chapter 3: Joan Riveriere: Gendered Masquerades. Chapter 4: Adrian Stokes: Ballet and Art. Chapter 5: Herbert Rosenfeld: Schizophrenics and Gangsters. Chapter 6: Wilfred Bion: Individual and Group Analysis. Chapter 7: Esther Bick: Infant Observation. Chapter 8: Frances Tustin: Anorexia and Autism. Chapter 9: Hanna Segal: Symbolism and Psychosis. Chapter 10: Ronald Britton: Exclusions and Elegies. Conclusion: Further Integrations. Notes. Index.
£49.50
John Wiley and Sons Ltd Mental Illness Polity Key Concepts in the Social
Book Synopsis* A concise and sophisticated introduction to the contested concept of Mental Illness . * Brings together a range of insights and interpretations from various disciplines including sociology, psychology, psychiatry and the neurosciences.Trade Review"Accessible yet rich, and consequently as valuable as, if not superior to, the similar texts that have preceded it. It will be of use to both groups of readers, those who are familiar with the material covered in it and those who are not, and is thus well-suited to the needs of a diverse professional audience."Journal of Mental Health"The relabelling of human distress and eccentricity as mental disorder is one of the great social changes of our time. Joan Busfield provides a breathtakingly lucid and remarkably comprehensive analysis of the vast cross-disciplinary terrain of argument about mental disorder and the meaning of the enormous expansion in disorder diagnoses over the past half-century. Busfield brings not only her sociologist's accomplished eye but also her trained clinician's understanding and a deft wielding of conceptual distinctions to the multifaceted debates over the meaning and social impact of mental disorder."Jerome C. Wakefield, Professor of Social Work and Psychiatry, New York University "Busfield has managed to capture in a single volume the breadth and depth of the highly contested and complex concept of mental illness. Original, accessible and engaging, this important book is a must-read."Kathleen Kendall, Senior Lecturer in Medical Education, University of Southampton "Busfield's book provides a valuable overview of the contested nature of mental illness, offering a balanced critique of some of the key debates regarding psychiatric concepts and categories. She cautions against the extension of psychiatric boundaries to include those experiences that are more helpfully understood in their social context, emphasising the contribution of many complex factors to the classification of mental illness. Her book deserves to be read by anyone interested in mental health and illness, including professionals and students."Kate Karban, Senior Lecturer in Social Work, University of BradfordTable of ContentsList of Figures and Tables Introduction 1 Concepts and Classifications 2 Counting Cases 3 Contested Causes 4 Critiques 5 Conceptual Controversies 6 Care, Control and Costs Conclusion References
£45.00
John Wiley & Sons Inc Neural Networks and Artificial Intelligence for
Book SynopsisUsing examples drawn from biomedicine and biomedical engineering, this essential reference book brings you comprehensive coverage of all the major techniques currently available to build computer-assisted decision support systems. You will find practical solutions for biomedicine based on current theory and applications of neural networks, artificial intelligence, and other methods for the development of decision aids, including hybrid systems. Neural Networks and Artificial Intelligence for Biomedical Engineering offers students and scientists of biomedical engineering, biomedical informatics, and medical artificial intelligence a deeper understanding of the powerful techniques now in use with a wide range of biomedical applications. Highlighted topics include: Types of neural networks and neural network algorithms Knowledge representation, knowledge acquisition, and reasoning methodologies Chaotic analysis of biomedical time series Table of ContentsPreface. Acknowledgments. Overview. NEURAL NETWORKS. Foundations of Neural Networks. Classes of Neural Networks. Classification Networks and Learning. Supervised Learning. Unsupervised Learning. Design Issues. Comparative Analysis. Validation and Evaluation. ARTIFICIAL INTELLIGENCE. Foundation of Computer-Assisted Decision Making. Knowledge Representation. Knowledge Acquisition. Reasoning Methodologies. Validation and Evaluation. ALTERNATIVE APPROACHES. Genetic Algorithms. Probabilistic Systems. Fuzzy Systems. Hybrid Systems. HyperMerge, a Hybird Expert System. Future Perspectives. Index. About the Authors.
£163.76
John Wiley and Sons Ltd Clinical and Laboratory Manual of Implant
Book SynopsisDr. Hamid Shafie's Clinical and Laboratory Manual of Implant Overdentures is a ground-breaking guide to this popular and effective treatment modality, which is increasingly seen as the standard of care for the fully edentulous patient.Trade Review“All phases of implant overdenture therapy are covered. The outstanding clinical documentations and illustrations are presented step by step and easy to follow. Dr. Shafie and his contributors provided the clinician and all members of the implant team excellent material that covers all facets of the implant practice and specifically the implant overdenture. This book will serve as a must-have reference, even for the experienced clinicians. This is an outstanding and complete book for implant overdentures.” (Implant Dentistry, September 2008) "Dr Shafie and his contributors provide the clinician and all members of the implant team with excellent material that covers all facets of the implant practice and specifically the implant overdenture. This book will serve as a must-have reference, even for the experienced clinician. The detailed illustrations and supportive clinical documentations are easy to follow and address every step, form initial consultation to final delivery and recall. This is an outstanding and complete book for implant overdentures." (Implant Dentistry) Table of ContentsCONTRIBUTORS, xiii FOREWORD, xv Dennis Tarnow FOREWORD, xvi Zhimon Jacobson INTRODUCTION, 1 Hamid Shafie 1 Patient Preferences Expectations, 3 Hamid Shafie 2 Diagnosis and Treatment Planning, 11 Hamid Shafie 3 Surgical Guide and Diagnostic Stent, 24 Hamid Shafie, Wolfram Stein, and Amir Juzbasic 4 Principles of Attachment Selection, 31 Hamid Shafie 5 Stud Attachments, 37 Hamid Shafie and James Ellison 6 Bar Attachments, 63 Hamid Shafie and James Ellison 7 Spark Erosion, 85 Hamid Shafie, Eduard Eisenmann, and Gunter Rubeling 8 Success with Implant Overdenture, 104 Hamid Shafie 9 Occlusion and Implant-Supported Overdenture, 112 Hamid Shafie and Frank Luaciello 10 Surgical Considerations for Implant Overdenture, 132 Richard Green, George Obeid, Eskow, and Hamid Shafie 11 Straumann Implant System, 153 Hamid Shafie 12 Endopore Dental Implant System, 161 Hamid Shafie 13 Overdenture Implants, 168 Hamid Shafie 14 Loading Approaches for Mandibular Implant Overdentures, 192 Dittmar May, George Romanos, and Hamid Shafie 15 Clinical Applications for the Measurement of Implant Stability Using Osstell Mentor, 206 Hamid Shafie and Neil Meredith 16 Follow Up and Maintenance of the Implant Overdenture, 210 Robert Eskow, Valerie Sternberg Smith and Roy Eskow 17 Core Principles of the Successful Implant Practice, 216 Sean Crabtree, Paul Homoly, Andress Charalabous, Peter Warkentin, and Kornelius Warkentin INDEX, 233
£135.85
John Wiley and Sons Ltd Salivary Diagnostics
Book SynopsisExplains and surveys one of the most exciting areas of oral biology research Demonstrates the clinical relevance and practical application of saliva diagnostics Inter-disciplinary relevance and appeal across industry and academia Written by luminary team headed by one of the world's recognized authorities in the field.Table of ContentsContributors viii Foreword xv Preface xvii Acknowledgment xviii I Background and Foundation 1 Salivary Gland Development and Regeneration 3 Sarah M. Knox and Matthew P. Hoffman 2 Salivary Gland Physiology Relevant to Diagnostics 14 Victor G. Romanenko and James E. Melvin 3 Saliva: Properties and Functions 27 Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink 4 Saliva Collectors 37 Arjan Vissink, Andy Wolff, and Enno C.I. Veerman 5 Salivary Secretion in Health and Disease 60 Michael D. Turner and Jonathan A. Ship 6 Processing and Storage of Saliva Samples 69 Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw Amerongen II Saliva Diagnostics 7 Historical Perspectives and Present 79 Frank G. Oppenheim 8 Diagnostics Other Than Blood 94 Sudhir Srivastava and Karl Krueger 9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104 Sreenivas Koka and David T. Wong 10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111 Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt 11 Human Salivary Proteomics 122 Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo 12 Genomic Targets in Saliva 129 Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong 13 Point-of-Care Diagnostics for Infectious diseases 136 Paul L.A.M. Corstjens, Daniel Malamud 14 Dental Caries Risk Assessment 150 Paul C. Denny and Patricia A. Denny 15 Periodontal Disease 156 Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile 16 Role of Saliva in Detection of Substance Abuse 169 Uttam Garg and Lance Presley 17 Head and Neck Cancer 180 Joseph A. Califano and Suhail K. Mithani 18 Sjogren's Syndrome 189 Philip C. Fox 19 Salivary Gland Dysfunction Associated with Systemic Disease 198 Nelson L. Rhodus 20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214 Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink 21 The Uses of Saliva in Forensic Genetics 226 Jack Ballantyne and Jane Juusola 22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233 Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. Wong III Saliva Diagnostics—A New Industry 23 Commercialization of Oral Fluid Products and Technologies 243 R. Sam Niedbala 24 Coverage and Reimbursement for Salivary Diagnostic Tests 255 James J. Crall 25 Saliva Diagnostics in the Dentist's and Physician's Office 263 Chakwan Siew and Milton V. Marshall 26 Salivary Hormones in Research and Diagnostics 270 Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel 27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278 Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng 28 Saliva Diagnostics—A New Industry 288 Stuart R. Smith, David T. Wong, and R. Michael Buch Index 295
£160.16
Wiley Dry Mouth The Malevolent Symptom
Book SynopsisXerostomia, more commonly called dry mouth, affects an estimated20 percentof adults worldwide and can severely diminish one's quality of life. Dry Mouth, the Malevolent Symptom: A Clinical Guide relies on evidence-based research to provide an introductory primer on oral dryness and the modalities available to treat it.The book describes the varied etiology of the disease, butemphasizes clinical protocols and step-by-step procedures for diagnosis and treatment planning. Dry Mouth is a user-friendly manual guiding clinicians through identifying and managing this common condition.Causes including radiotherapy, chemotherapy,systemic diseases, polypharmacy, and the natural progression of aging are discussed in conjunction with the clinical symptoms and signs associated with each one. Multiple avenues for treatment are presented, highlighting salivary stimulation and supplementation techniques, pharmacologic aids, and critically required oral therapy. Although intended primTrade Review"Specialists in oral medicine, other hospital-based specialists and anyone with an interest in research into salivary gland function would also find this book a worthwhile addition to their bookshelves." (Primary Dental Care and Team in Practice, 1 April 2011) "This condition can be difficult to manage, and this book makes it clear where more research is warranted... For students this is a must; for clinicians it is a great reference and some of the charts would be useful to have in the surgery." (Team in Practice, October 2010)Table of ContentsPreface. Acknowledgments. Introduction (Olav Alvares) In memoriam: Jonathan Ship (1959–2008)—a celebration of his life Editors and contributors 1. The enigma of dry mouth. 1.1 Dry mouth: a common worldwide tormentor (L.M. Sreebny). 1.2 Saliva: the remarkable fluid (A. van Nieuw Amerongen, E.C.I. Veerman and A. Vissink). 1.3 Living with the drought: the patient speaks (K. Morland Hammitt). 2. Dry mouth: a multifaceted diagnostic dilemma. 2.1 The odd couple: dry mouth and salivary flow (L.M. Sreebny). 2.2 Symptoms and semiotics (A. Vissink and L.M. Sreebny). 2.3 Sialometry: the measure of things, with ease and reliability (L.M. Sreebny and A. Visink). 2.4 Other ways to assess salivary gland disease (A. Vissink). 3. The causes of dry mouth: a broad panoply. 3.1 Drugs, dry mouth and dentistry (L.M. Sreebny). 3.1.1. Setting the stage. 3.1.2. Drugs and the salivary system. 3.1.3. Xerogenic drugs. 3.1.4. Detailed reference guide to drugs and dry mouth. 3.2 Dry Mouth: diseases and conditions. 3.2.1 The auto-immune connection (C.G.M. Kallenberg). 3.2.2 Head and neck radiotherapy: an iatrogenic factor (A. Eisbruch). 3.2.3 Brains and saliva (E.C.I. Veerman and J.A. Bosch). 3.2.4 Other causes of dry mouth: the list is endless (S. Beier Jensen, A.M. Lynge Pedersen and B. Nauntofte). 4. Treating dry mouth: help is available (J. Ship, A. Vissink and L.M. Sreebny). 5. And what about the future? 5.1 Is gene therapy the answer? (B.J. Baum, C. Zheng, L. McCullagh, A.P. Cotrim, J.S. Brahim, J.C. Atkinson, C.M. Goldsmith, N.P. Nikolov, R.J. Turner and G.G. Illei). 5.2 Is stem cell therapy a reasonable approach? (R.P. Coppes and I. Lombaert). 7. Index.
£71.96
John Wiley and Sons Ltd Health Behavior Change in the Dental Practice
Book SynopsisHealth Behavior Change in the Dental Practice presents an overview of health behavior change, focusing on the spirit of motivational interviewing. Targeting the clinical application of the principles, the book applies lessons learned from the field of general and behavioral medicine to the dental practice.Table of ContentsForeword Preface List of Contributors 1. Introduction to Health Behavior Change for the Dental Practice Health Care in the Twenty-first Century The Opportunity in the Dental Setting Adop tion and Integration of Health Behavior Change The Role and Responsibility of the Dental Professional Collaborative Care Toward Whole Health References 2. The Challenge of Behavior Change Introduction Behavior Change: Some Key Concepts The Patient’s Perspective The Clinician’s Perspective Understanding Health Behavior Change Social Cognitive Theory and Self-Efficacy Theory The Health Belief Model Theory of Planned Behavior The Transtheoretical Model of Behavior Change Self-Determination Theory Summary References 3. Communication and Health Behavior Change Counselling Introduction The Relationship between the Clinician and the Patient Styles of Communication Directing Following Guiding Key Skills for Communicating about Health Behavior Change Question 1: Is the patient happy to talk with you about behavior change? Question 2: How are you asking questions? Question 3: How do you provide support? Question 4: How do you convey understanding? Question 5: How do you get information across? Question 6: How do you bring it all together? Summary Acknowledgments References 4. Motivational Interviewing (MI) and Its Basic Tools Introduction What Is Motivational Interviewing? Research Evidence for MI What Triggers Behavior Change? Motivation and the Clinician-Patient Relationship Definition of MI “Spirit” of MI Major Principles Express Empathy Develop Discrepancy Roll with Resistance Support Self-Efficacy OARS: Basic Tools for Building Motivation to Change Use Open-Ended Questions Affirm Patients Use Reflective Listening Use Summaries Elicit Change Talk Evocative Questions Decisional Balance or Pros and Cons Matrix The Importance Ruler Elaborating, Querying Extremes, and Looking Back and Forward Exploring Goals and Values Responding to Change Talk Responding to Resistance Enhancing Confidence Strengthening Commitment Negotiating a Plan for Change Summary References 5. Brief Interventions in Promoting Health Behavior Change Introduction Using a Patient-Centered Approach Righting Reflex Goals of Brief Interventions Assessing Motives Health History Form Open-Ended Questions Readiness Scales Raising Awareness Giving Information versus Raising Awareness Conveying Understanding Supporting Change Encouraging Patient Problem Solving Offering a Set of Strategies Planning for the Change Use of the Telephone for Brief Interventions Use of Computers for Brief Interventions Giving Brief Advice When Brief Interventions Are Not Appropriate Bringing It All Together Summary References 6. Implementation of Health Behavior Change Principles in Dental Practice Introduction Content of Change (the Objectives) Context of Change (the Environment) Process of Change (the Implementation Plan) Micro-Environment: The Dental Visit Easier than You Think Patient Activation Fabric for the Dental Visit (Implementation Model) “Your Patient Is Here,” Single Behavior Patient Scenario Multiple Behavior Patient Scenario Macro-Environment: The Practice Setting Importance of Support Overcoming Potential Obstacles to Practice Implementation Practical Guidance for Beginners (or Non-Beginners) Summary References 7. Health Behavior Change Education Introduction History of Medical and Dental Education In Medicine In Dentistry In Dental Hygiene Currents Trends in Dental Care and Education The Need for Change in Dental Education Public Health Goals and Responsibilities New Educational Initiatives and Methods Theoretical Education Pathology and Epidemiology of Diseases Behavior as a Determinant of Health and Disease Practical Education Students Continuing Education Clinicians Assessment of Health Behavior Change Education Faculty Students Clinicians Summary References Index
£46.76
John Wiley and Sons Ltd Implant Site Development
Book Synopsis* Addresses implant site development and related treatment planning in a logical, practical and easy-to-digest manner * Surveys the whole gamut of site development techniques * Unique integrated clinical approach * Presents a sound and thorough review of evidence .Trade Review“This book introduces and makes clear these recent innovations to all clinicians.” (British Dental Association News, 1 December 2012”Table of ContentsContributors Foreword Acknowledgments 1 Principles of bone biology and regeneration William V. Giannobile and Hector F. Rios 2 Bone anatomy George A. Mandelaris and Alan L. Rosenfeld 3 Treatment philosophy Debby Hwang and Michael Sonick 4 Decision-making algorithm for regeneration of the periodontally compromised tooth: maintaining these teeth when dental implants provide a compelling alternative treatment option Paul S. Rosen and Stuart J. Froum 5 The making of beautiful smiles in perio-implantology André P. Saadoun 6 CT/CBCT diagnosis and treatment planning concepts for bone grafting applications Scott D. Ganz 7 Implant site development: socket preservation Jack T. Krauser and Avi Schetritt 8 Implant interactions in orthodontics Frank Celenza 9 Guided bone regeneration: Concepts and materials Debby Hwang and Michael Sonick 10 Implant site preparation: Horizontal ridge augmentation using particulate allograft and the principles of GBR Michael Sonick and Debby Hwang 11 Guided bone regeneration: Peri-implantation Debby Hwang and Michael Sonick 12 Guided bone regeneration: Vertical growth Istvan Urban 13 Intraoral bone grafts for dental implants Craig M. Misch 14 Bone grafting in large bone defects and extreme atrophy situations Nardy Casap and Yuval Samuni 15 Sinus elevation: Osteotome-mediated approach Michael Toffler 16 Sinus elevation: Lateral wall approach Tomaso Vercellotti 17 Distraction osteogenesis Michael S. Block and Christopher Haggerty 18 Immediate implant placement: A comprehensive understanding for achieving optimal clinical success Robert A. Faiella 19 Soft tissue augmentation: Pre-, peri-, and postimplantation Stefan Fickl and Markus B. Hürzeler 20 Soft tissue enhancement after implant placement Christian F.J. Stappert and Davide Romeo 21 Soft tissue augmentation: allograft Peter C. Shatz and Lee H. Silverstein 22 Soft tissue development with provisional and definitive implant restorations George Priest 23 Bioengineering concepts Eduardo Anitua and Gorka Orive Index
£161.06
Seagull Books London Ltd Conversations with Jacqueline Rose
Book SynopsisIn this collection of conversations that were conducted in Calcutta, at the London School of Economics, through Jewish Book Week, and on the radical website openDemocracy, internationally renowned Jewish scholar Jacqueline Rose explores the debates that have fueled her writing and thinking over three decades. Drawn out by her interlocutors, Rose discusses the difference between political and sexual identity and inquires whether psychoanalysis can be considered a radical form of thought that can be used fruitfully in dialogue about political struggle. Most significantlysince each of these conversations were sparked by her recent and controversial writing on Zionism, Israel, and PalestineRose reflects on the role of Jewish dissent in our time. In these conversations, Rose appears courageous, passionate, ethical, and never afraid to engage politically on issues that are of human concern in the ongoing Middle and Near East crisis.
£10.99
Wiley Manual of Nail Disease and Surgery
Book SynopsisIntended as a practical guide to the treatment of nail problems through medical and surgical means, this book is aimed at the general practitioner, dermatologist and podiatrist. The emphasis throughout is on practical procedures which are in the main relatively simple.Table of ContentsPreface;. 1. Anatomy and Physiology of the Nail Apparatus;. 2. Nail Unit Infections;. 3. Nail Signs and Systemic Disease;. 4. The Nail in Dermatological Diseases;. 5. Occupational Nail Disorders;. 6. Nail Cosmetology;. 7. Nail Unit Tumours and Surgery;. Index
£125.06
John Wiley and Sons Ltd SelfAssessment for Mrcp Part 1
Book SynopsisThe new MRCP Part 1 Paediatrics is a major development in the training of pediatricians. This book is comprised of 350 entirely new questions and indepth explanations. A major feature of the book is a 60 question test designed to be used as practice for the real examination. Both authors participate in teaching pediatricians in training.Table of ContentsIntroduction;. Basic and Clinical Sciences;. Cardiology;. Dermatology;. ENT and Ophthalmology;. Gastroenterology and Nutrition;. Genetics;. Growth and Endocrinology;. Haematology and Oncology;. Immunology and Infections;. Metabolic Disorders;. Neonatology;. Neurology;. Psychiatry and Social Medicine;. Renal Medicine;. Respiratory Medicne;. Surgery;. Therapeutics;. Test Paper;. Bibliography;. Index
£44.60
John Wiley and Sons Ltd Science and Medicine in Sport
Book SynopsisIncludes both sports science and medicine, providing applied information for medical practitioners and other allied health professional, as well as postgraduate students. This book covers both the prevention and treatment of injury, with cross-referenced sections on sports science and sports medicine.Table of ContentsEditors. List of Authors. Special Contributors. Preface to First Edition. Preface to Second Edition. Acknowledgement. Section 1: The Anatomy and Biomechanics of Sport Performance. Applied Anatomy (T. R. Ackland, J. Bloomfield). Biomechanical Principles (B. C. Elliott, G. A. Wood). Biomechanical Analysis (R. N. Marshall, B. C. Elliott). Section 2: Physiology and Nutrition Applied to Sport. Physiology of Training (A. G. Hahn). Nutrition and Energy Sources (V. Deakin, J. R. Brotherhood). Environmental Stress (F. S. Pyke, J. R. Sutton). Section 3: Sport Psychology and Performance Enhancement. Self-regulation and Goal Setting (A. M. D. Gordon). The Individual Athlete (J. W. Bond). Team Athletes (B. P. Miller). The Psychological Aspects of Injury in Sport (J. R. Grove, A. M. D. Gordon). Talent Identification and Profiling (J. Bloomfield). Section 4: Sports Medicine. Classification of Injuries and Mechanisms of Injury, Repair, Healing and Soft Tissue Remodelling (B. W. Oakes). Principles of Treatment and Rehabilitation (C. R. Purdam, P. A. Fricker, B. Cooper). Imaging in Sports Medicine (I. F. Anderson, J. A. Booth). Injuries to the Head, Eye and Ear (A. P. Garnham). Dental Problems (J. P. Fricker, M. L. O’Neill). Injuries to the Spine (K. F. Maguire). Injuries to the Chest and Abdomen (W. Johnson). Injuries to the Shoulder Girdle and Upper Limb (P. A. Fricker, G. Hoy). Injuries to the Pelvis and Lower Limb (K. J. Crichton, P. A. Fricker, C. Purdam, A. S. Watson). Section 5: Special Considerations in Sports Medicine. The Team Physician (B. G. Sando). Children in Sport (A. S. Watson). The Female Athlete (R. J. Carbon). The Disabled Athlete (K. E. Fallon). Medical Considerations in Aquatic Sports (J. J. Kellett). Doping (K. D. Fitch, S. P. Haynes). Exercise and Immunity (D. B. Pyne, A. B. Gray, W. A. McDonald). Special Medical Considerations. Part I. Asthma (A. R. Morton). Part II. Epilepsy (R. A. Reid). Part III. Diabetes Mellitus (D. J. Chisholm). Part IV. Podiatry (A. S. Watson). Part V. Exercise Stress Testing (B. E. F. Hockings). Part VI. Eating Disorders (P. N. Gilchrist, L. Burke). Appendix 1: Orchard Sports Injury Classification System (J. Orchard). Index
£85.45
John Wiley and Sons Ltd Noninvasive Positive Pressure Ventilation
Book SynopsisNoninvasive Positive Pressure Ventilation offers practical, evidence-based advice from experienced authors on the selection of appropriate patients, equipment and techniques used in the initiation of noninvasive positive pressure ventilation (NPPV). It discusses how to anticipate and resolve possible problem scenarios, and how to implement and monitor NPPV programs both in hospitals and in the patient''''s home. Defined as ventilatory assistance given without the need for an invasive airway, NPPV is often preferred over invasive mechanical ventilation because it is more convenient to use, more comfortable for the patient, and avoids complications of invasive mechanical ventilation including upper airway trauma, nosocomial pneumonias, sinusitis and sepsis. However, recipients of NPPV must be carefully selected and considerable skill and experience are necessary for successful implementation. This book aims to provide readers with knowledge that will contribute to that success. Table of ContentsContributors. Foreword (Anita K. Simonds, M.D.). Introduction. 1. Equipment Used for Noninvasive Positive Pressure Ventilation (Dean Hess, Ph.D., R.R.T.). 2. Initiation of Noninvasive Positive Pressure Ventilation (Nicholas S. Hill, M.D., Dean Hess, Ph.D., R.R.T.). 3. Management and Monitoring of Noninvasive Positive Pressure Ventilation (Peter C. Gay, M.D., Nicholas S. Hill, M.D.). 4. Noninvasive Mechanical Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (Nicolino Ambrosino, M.D., Michele Vitacca, M.D.). 5. Noninvasive Positive Pressure Ventilation for Non Chronic Obstructive Pulmonary Disease Causes of Acute Respiratory Failure (Nicholas S. Hill, M.D.). 6. Other Applications of Noninvasive Positive Pressure Ventilation in the Acute Care Setting (Nicholas S. Hill, M.D.). 7. Nasal Positive Pressure Ventilation in Restrictive Thoracic and Central Hypoventilatory Disorders (Patrick Leger, M.D., Nicholas S. Hill, M.D.). 8. Noninvasive Ventilation in Severe Stable Chronic Obstructive Pulmonary Disease (Mark W. Elliott, M.D., Nicholas S. Hill, M.D.). 9. Application of Noninvasive Positive Pressure Ventilation in Children (W. Gerald Teague, M.D., David M. Lang, M.D.). 10. Problems, Remedies, and Strategies to Optimize the Success of Noninvasive Ventilation (Nicholas S. Hill, M.D.). 11. Program Development, Costs, Resource Utilization, and Outcomes Assessment for Noninvasive Ventilation (DeLynn Johnston, B.S., R.R.T., Nicholas S. Hill, M.D.). Appendix. Index.
£99.86
John Wiley and Sons Ltd Birth Asphyxia and the Brain
Book SynopsisThis text presents a state-of-the-art review of asphyxial brain injury to the foetus and new born, a leading source of both neonatal mortality and long-term neurologic disability. Beginning with an historical overview of birth-related injury, followed by an epidemiologic review of the relationship of birth injury to later neuromotor disability, it provides a detailed analysis and exhaustive review of each aspect. The contributors are among the most knowledgeable international authorities in the field; they have synthesized a uniformity of medical and scientific quality, clarity of style, and thoroughness of scope. Continual emphasis is placed on the material''s relevance and usefulness to clinicians; equally important is the emphasis on communication between clinicians and basic neuroscientists. The task of paediatricians and neonatologists in coming years will be to better understand the mechanism of brain damage, the prediction of disability, and the introduction of efficacious neTable of ContentsForeword. Harvey B. Sarnat. Part I. History and Epidemiology. Chapter 1. Cerebral Palsy and Its Causes: Historical Perspectives. Tonse N.K. Raju. Chapter 2. The Relationship of Birth Asphyxia to Later Motor Disability. Michael P. Collins, Nigel S. Paneth. . Part II. Basic Science. . Chapter 3. The Biochemical Neurotoxic Cascade in Hypoxic-Ischemic Injury. Michael V. Johnston, Akira Ishida, Wako Nakajima, William Trescher. Chapter 4. Inflammation and Neonatal Brain Injury. John D.E. Barks, Faye S. Silverstein. Chapter 5. Glucose, Acidosis, and the Developing Brain. Robert C. Vannucci, Susan J. Vannucci. Chapter 6. Energy Consequences of Cerebral Hypoxia-Ischemia. John S. Wyatt. Chapter 7. Apoptosis and Necrosis in Perinatal Brain Injury. Huseyin Mehmet, A. David Edwards. Chapter 8. Effects of Nitric Oxide on Neuronal and Cerebrovascular Function. Donna M. Ferriero, Stephen Ashwal. Chapter 9. Free Radical-Mediated Processes. Ola Didrik Saugstad. . Part III. Clinical Implications. Chapter 10. Antepartum Hypoxemia and the Developing Fetus. Donald M. Peebles, Mark A. Hanson. Chapter 11. Intrapartum Hypoxic-Ischemic Brain Injury. Jenny A. Westgate, Laura Bennet, Alistair J. Gunn. Chapter 12. Clinical Management of the Asphyxiated Newborn. Malcolm Levene, Sunil K. Sinha. Chapter 13. Neuroimaging of Hypoxic-Ischemic Encephalopathy. Mary Rutherford. Chapter 14. Thermal Influence on the Asphyxiated Newborn. Marianne Thoresen. . Part IV Medico-Legal Aspects. Chapter 15. Medico-Legal Implications of Hypoxic-Ischemic Brain Injury. Steven M. Donn, Malcolm L. Chiswick, Paula Whittell, Susan Anderson.
£143.95
Wiley Interactions of Blood and the Pulmonary Circulations
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£100.76
John Wiley & Sons Inc Doppler Radar Physiological Sensing
Book SynopsisPresents a comprehensive description of the theory and practical implementation of Doppler radar-based physiological monitoring This book includes an overview of current physiological monitoring techniques and explains the fundamental technology used in remote non-contact monitoring methods.Table of ContentsList of Contributors xi 1 Introduction 1Amy D. Droitcour, Olga Boric-Lubecke, Shuhei Yamada, and Victor M. Lubecke 1.1 Current Methods of Physiological Monitoring, 2 1.2 Need for Noncontact Physiological Monitoring, 3 1.2.1 Patients with Compromised Skin, 3 1.2.2 Sleep Monitoring, 4 1.2.3 Elderly Monitoring, 5 1.3 Doppler Radar Potential for Physiological Monitoring, 5 1.3.1 Principle of Operation and Power Budget, 6 1.3.2 History of Doppler Radar in Physiological Monitoring, 8 References, 16 2 Radar Principles 21Ehsan Yavari, Olga Boric-Lubecke, and Shuhei Yamada 2.1 Brief History of Radar, 21 2.2 Radar Principle of Operation, 22 2.2.1 Electromagnetic Wave Propagation and Reflection, 23 2.2.2 Radar Cross Section, 24 2.2.3 Radar Equation, 25 2.3 Doppler Radar, 28 2.3.1 Doppler Effect, 28 2.3.2 Doppler Radar Waveforms: CW, FMCW, Pulsed, 29 2.4 Monostatic and Bistatic Radar, 32 2.5 Radar Applications, 35 References, 36 3 Physiological Motion and Measurement 39Amy D. Droitcour and Olga Boric-Lubecke 3.1 Respiratory System Motion, 39 3.1.1 Introduction to the Respiratory System, 39 3.1.2 Respiratory Motion, 40 3.1.3 Chest Wall Motion Associated with Breathing, 43 3.1.4 Breathing Patterns in Disease and Disorder, 43 3.2 Heart System Motion, 44 3.2.1 Location and Gross Anatomy of the Heart, 45 3.2.2 Electrical and Mechanical Events of the Heart, 46 3.2.3 Chest Surface Motion Due to Heart Function, 48 3.2.4 Quantitative Measurement of Chest Wall Motion Due to Heartbeat, 50 3.3 Circulatory System Motion, 53 3.3.1 Location and Structure of the Major Arteries and Veins, 54 3.3.2 Blood Flow Through Arteries and Veins, 55 3.3.3 Surface Motion from Blood Flow, 56 3.3.4 Circulatory System Motion: Variation with Age, 57 3.4 Interaction of Respiratory, Heart, and Circulatory Motion at the Skin Surface, 58 3.5 Measurement of Heart and Respiratory Surface Motion, 58 3.5.1 Radar Measurement of Physiological Motion, 59 3.5.2 Surface Motion Measurement of Respiration Rate, 59 3.5.3 Surface Motion Measurement of Heart/Pulse Rate, 61 References, 63 4 Physiological Doppler Radar Overview 69Aditya Singh, Byung-Kwon Park, Olga Boric-Lubecke, Isar Mostafanezhad, and Victor M. Lubecke 4.1 RF Front End, 70 4.1.1 Quadrature Receiver, 73 4.1.2 Phase Coherence and Range Correlation, 77 4.1.3 Frequency Choice, 79 4.1.4 Antenna Considerations, 80 4.1.5 Power Budget, 80 4.2 Baseband Module, 83 4.2.1 Analog Signal Conditioning and Coupling Methods, 83 4.2.2 Data Acquisition, 85 4.3 Signal Processing, 86 4.3.1 Phase Demodulation, 86 4.3.2 Demodulated Phase Processing, 87 4.4 Noise Sources, 90 4.4.1 Electrical Noise, 90 4.4.2 Mechanical Noise, 92 4.5 Conclusions, 92 References, 93 5 CW Homodyne Transceiver Challenges 95Aditya Singh, Alex Vergara, Amy D. Droitcour, Byung-Kwon Park, Olga Boric-Lubecke, Shuhei Yamada, and Victor M. Lubecke 5.1 RF Front End, 95 5.1.1 Single-Channel Limitations, 96 5.1.2 LO Leakage Cancellation, 103 5.1.3 IQ Imbalance Assessment, 109 5.2 Baseband Module, 113 5.2.1 AC and DC Coupling, 113 5.2.2 DC Canceller, 114 5.3 Signal Demodulation, 118 5.3.1 DC Offset and DC Information, 118 5.3.2 Center Tracking, 125 5.3.3 DC Cancellation Results, 130 References, 134 6 Sources of Noise and Signal-to-Noise Ratio 137Amy D. Droitcour, Olga Boric-Lubecke, and Shuhei Yamada 6.1 Signal Power, Radar Equation, and Radar Cross Section, 138 6.1.1 Radar Equation, 138 6.1.2 Radar Cross Section, 140 6.1.3 Reflection and Absorption, 141 6.1.4 Phase-to-Amplitude Conversion, 141 6.2 Oscillator Phase Noise, Range Correlation and Residual Phase Noise, 143 6.2.1 Oscillator Phase Noise, 143 6.2.2 Range Correlation and Residual Phase Noise, 147 6.3 Contributions of Various Noise Sources, 151 6.3.1 Phase Noise, 151 6.3.2 Baseband 1/f Noise, 154 6.3.3 RF Additive White Gaussian Noise, 154 6.4 Signal-to-Noise Ratio, 155 6.5 Validation of Range Correlation, 157 6.6 Human Testing Validation, 158 References, 168 7 Doppler Radar Physiological Assessments 171John Kiriazi, Olga Boric-Lubecke, Shuhei Yamada, Victor M. Lubecke, and Wansuree Massagram 7.1 Actigraphy, 172 7.2 Respiratory Rate, 176 7.3 Tidal Volume, 179 7.4 Heart Rates, 184 7.5 Heart Rate Variability, 185 7.6 Respiratory Sinus Arrhythmia, 190 7.7 RCs and Subject Orientation, 196 References, 204 8 Advanced Performance Architectures 207Aditya Singh, Aly Fathy, Isar Mostafanezhad, Jenshan Lin, Olga Boric-Lubecke, Shuhei Yamada, Victor M. Lubecke, and Yazhou Wang 8.1 DC Offset and Spectrum Folding, 208 8.1.1 Single-Channel Homodyne System with Phase Tuning, 208 8.1.2 Heterodyne System with Frequency Tuning, 213 8.1.3 Low-IF Architecture, 220 8.2 Motion Interference Suppression, 224 8.2.1 Interference Cancellation, 226 8.2.2 Bistatic Radar: Sensor Nodes, 231 8.2.3 Passive RF Tags, 240 8.3 Range Detection, 250 8.3.1 Physiological Monitoring with FMCW Radar, 250 8.3.2 Physiological Monitoring with UWB Radar, 251 References, 266 9 Applications and Future Research 269Aditya Singh and Victor M. Lubecke 9.1 Commercial Development, 269 9.1.1 Healthcare, 269 9.1.2 Defense, 272 9.2 Recent Research Areas, 272 9.2.1 Sleep Study, 272 9.2.2 Range, 275 9.2.3 Multiple Subject Detection, 276 9.2.4 Animal Monitoring, 279 9.3 Conclusion, 282 References, 282 Index 285
£109.76
John Wiley & Sons Inc Biomedical Materials and Diagnostic Devices
Book SynopsisThe functional materials with the most promising outlook have the ability to precisely adjust the biological phenomenon in a controlled mode.Table of ContentsPreface xv Part I: Biomedical Materials 1. Application of the Collagen as Biomaterials 3 Kwangwoo Nam and Akio Kishida 1.1 Introduction 3 1.2 Structural Aspect of Native Tissue 5 1.3 Processing of Collagen Matrix 8 1.4 Conclusions and Future Perspectives 14 2. Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates 19 Sergey V. Dorozhkin 2.1 Introduction 19 2.2 General Information on ?Nano? 21 2.3 Micron- and Submicron-Sized Calcium Orthophosphates versus the Nanodimensional Ones 23 2.4 Nanodimensional and Nanocrystalline Calcium Orthophosphates in Calcified Tissues of Mammals 26 2.5 The Structure of the Nanodimensional and Nanocrystalline Apatites 28 2.6 Synthesis of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 34 2.7 Biomedical Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 47 2.8 Other Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 58 2.9 Summary and Perspectives 58 2.10 Conclusions 61 3. Layer-by-Layer (LbL) Thin Film: From Conventional To Advanced Biomedical and Bioanalytical Applications 101 Wing Cheung MAK 3.1 State-of-the-art LbL Technology 101 3.2 Principle of Biomaterials Based Lbl Architecture 102 3.3 LbL Thin Film for Biomaterials and Biomedical Implantations 103 3.4 LbL Thin Film for Biosensors and Bioassays 105 3.5 LbL Thin Film Architecture on Colloidal Materials 107 3.6 LbL Thin Film for Drug Encapsulation and Delivery 108 3.7 LbL Thin Film Based Micro/Nanoreactor 110 4. Polycaprolactone based Nanobiomaterials 115 Narendra K. Singh and Pralay Maiti 4.1 Introduction 115 4.2 Preparation of Polycaprolactone Nanocomposites 118 4.3 Characterization of Poly(caprolactone) Nanocomposites 119 4.4 Properties 123 4.5 Biocompatibility and Drug Delivery Application 141 4.6 Conclusion 150 Acknowledgement 150 5. Bone Substitute Materials in Trauma and Orthopedic Surgery ? Properties and Use in Clinic 157 Esther M.M. Van Lieshout 5.1 Introduction 158 5.2 Types of Bone Grafts 159 5.3 Bone Substitute Materials 161 5.4 Combinations with Osteogenic and Osteoinductive Materials 171 5.5 Discussion and Conclusion 173 6. Surface Functionalized Hydrogel Nanoparticles 191 Mehrdad Hamidi, Hajar Ashrafi and Amir Azadi 6.1 Hydrogel Nanoparticles 191 6.2 Hydrogel Nanoparticles Based on Chitosan 193 6.3 Hydrogel Nanoparticles Based on Alginate 194 6.4 Hydrogel Nanoparticles Based on Poly(vinyl Alcohol) 195 6.5 Hydrogel Nanoparticles Based on Poly(ethylene Oxide) and Poly(ethyleneimine) 196 6.6 Hydrogel Nanoparticles Based on Poly(vinyl Pyrrolidone) 198 6.7 Hydrogel Nanoparticles Based on Poly-N-Isopropylacrylamide 198 6.8 Smart Hydrogel Nanoparticles 199 6.9 Self-assembled Hydrogel Nanoparticles 200 6.10 Surface Functionalization 201 6.11 Surface Functionalized Hydrogel Nanoparticles 205 Part II: Diagnostic Devices 7. Utility and Potential Application of Nanomaterials in Medicine 215 Ravindra P. Singh, Jeong -Woo Choi, Ashutosh Tiwari and Avinash Chand Pandey 7.1 Introduction 215 7.2 Nanoparticle Coatings 218 7.3 Cyclic Peptides 220 7.4 Dendrimers 221 7.5 Fullerenes/Carbon Nanotubes/Graphene 227 7.6 Functional Drug Carriers 229 7.7 MRI Scanning Nanoparticles 233 7.8 Nanoemulsions 235 7.9 Nanofibers 236 7.10 Nanoshells 239 7.11 Quantum Dots 240 7.12 Nanoimaging 248 7.13 Inorganic Nanoparticles 248 7.14 Conclusion 250 8. Gold Nanoparticle-based Electrochemical Biosensors for Medical Applications 261 Ülkü Anik 8.1 Introduction 261 8.2 Electrochemical Biosensors 262 8.3 Conclusion 272 9. Impedimetric DNA Sensing Employing Nanomaterials 277 Manel del Valle and Alessandra Bonanni 9.1 Introduction 277 9.2 Electrochemical Impedance Spectroscopy for Genosensing 280 9.3 Nanostructured Carbon Used in Impedimetric Genosensors 286 9.4 Nanostructured Gold Used in Impedimetric Genosensors 290 9.5 Quantum Dots for Impedimetric Genosensing 293 9.6 Impedimetric Genosensors for Point-of-Care Diagnosis 293 9.7 Conclusions (Past, Present and Future Perspectives) 294 10. Bionanocomposite Matrices in Electrochemical Biosensors 301 Ashutosh Tiwari, Atul Tiwari 10.1 Introduction 301 10.2 Fabricationof SiO2-CHIT/CNTs Bionanocomposites 303 10.3 Preparation of Bioelectrodes 304 10.4 Characterizations 305 10.5 Electrocatalytic Properties 307 10.6 Photometric Response 315 10.7 Conclusions 316 11. Biosilica? Nanocomposites - Nanobiomaterials for Biomedical Engineering and Sensing Applications 321 Nikos Chaniotakis, Raluca Buiculescu 11.1 Introduction 321 11.2 Silica Polymerization Process 323 11.3 Biocatalytic Formation of Silica 325 11.4 Biosilica Nanotechnology 327 11.5 Applications 328 11.6 Conclusions 334 12. Molecularly Imprinted Nanomaterial-based Highly Sensitive and Selective Medical Devices 337 Bhim Bali Prasad and Mahavir Prasad Tiwari 12.1 Introduction 337 12.2 Molecular Imprinted Polymer Technology 340 12.3 Molecularly Imprinted Nanomaterials 360 12.4 Molecularly Imprinted Nanomaterial-based Sensing Devices 362 12.5 Conclusion 379 13. Immunosensors for Diagnosis of Cardiac Injury 391 Swapneel R. Deshpande, Aswathi Anto Antony, Ashutosh Tiwari, Emilia Wiechec, Ulf Dahlström, Anthony P.F. Turner 13.1 Immunosensor 391 13.2 Myocardial Infarction and Cardiac Biomarkers 392 13.3 Immunosensors for Troponin 399 13.4 Conclusions 404 Part III: Drug Delivery and Therapeutics 14. Ground-Breaking Changes in Mimetic and Novel Nanostructured Composites for Intelligent-, Adaptive- and In vivo-responsive Drug Delivery Therapies 411 Dipak K. Sarker 14. 1 Introduction 411 14.2 Obstacles to the Clinician 420 14.3 Hurdles for the Pharmaceuticist 428 14.4 Nanostructures 431 14.5 Surface Coating 435 14.7 Formulation Conditions and Parameters 439 14.8 Delivery Systems 440 14.9 Evaluation 443 14.10 Conclusions 447 15. Progress of Nanobiomaterials for Theranostic Systems 451 Dipendra Gyawali, Michael Palmer, Richard T. Tran and Jian Yang 15.1 Introduction 451 15.2 Design Concerns for Theranostic Nanosystems 456 15.3 Designing a Smart and Functional Theranostic System 459 15.4 Materials for Theranostic System 462 15.5 Theranostic Systems and Applications 474 15.6 Future Outlook 481 16. Intelligent Drug Delivery Systems for Cancer Therapy 493 Mousa Jafari, Bahram Zargar, M. Soltani, D. Nedra Karunaratne, Brian Ingalls, P. Chen 16.1 Introduction 493 16.2 Peptides for Nucleic Acid and Drug Delivery in Cancer Therapy 494 16.3 Lipid Carriers 499 16.4 Polymeric Carriers 506 16.5 Bactria Mediated Cancer Therapy 514 16.6 Conclusion 519 Part IV: Tissue Engineering and Organ Regeneration 531 17. The Evolution of Abdominal Wall Reconstruction and the Role of Nonobiotecnology in the Development of Intelligent Abdominal Wall Mesh 533 Cherif Boutros, Hany F. Sobhi and Nader Hanna 17.1 The Complex Structure of the Abdominal Wall 534 17.2 Need for Abdominal Wall Reconstruction 535 17.3 Failure of Primary Repair 535 17.4 Limitations of the Synthetic Meshes 536 17.5 Introduction of Biomaterials To Overcome Synthetic Mesh Limitations 537 17.6 Ideal Material for Abdominal Wall Reconstruction 538 17.7 Role of Bionanotechnology in Providing the 17.7 Future Directions 542 18. Poly(Polyol Sebacate)-based Elastomeric Nanobiomaterials for Soft Tissue Engineering 545 Qizhi Chen 18.1 Introduction 545 18.2 Poly(polyol sebacate) Elastomers 547 18.3 Elastomeric Nanocomposites 562 18.4 Summary 569 19. Electrospun Nanomatrix for Tissue Regeneration 577 Debasish Mondal and Ashutosh Tiwari 19.1 Introduction 577 19.2 Electrosun Nanomatrix 578 19.3 Polymeric Nanomatrices for Tissue Engineering 580 19.4 Biocompatibility of the Nanomatrix 581 19.5 Electrospun Nanomatrices for Tissue Engineering 583 19.6 Status and Prognosis 592 20. Conducting Polymer Composites for Tissue Engineering Scaffolds 597 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 20.1 Introduction 598 20.3 Synthesis of Conducting Polymers 599 20.4 Application of Conducting Polymer in Tissue Engineering 600 20.5 Polypyrrole 600 20.6 Poly(3,4-ethylene dioxythiophene) 602 20.7 Polyaniline 603 20.8 Carbon Nanotube 605 20.9 Future Prospects and Conclusions 607 21. Cell Patterning Technologies for Tissue Engineering 611 Azadeh Seidi and Murugan Ramalingam 21.1 Introduction 611 21.2 Patterned Co-culture Techniques 612 21.3 Applications of Co-cultures in Tissue Engineering 618 21.4 Concluding Remarks 619 Acknowledgements 619 References 620 Index 000
£188.96
John Wiley & Sons Inc Drugdevice Combinations for Chronic Diseases
Book SynopsisThis book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice. The book: Discusses where drugs and devices work, where they fail, and when they need to work with each other Reviews interactions betweenhuman bodies and the drug-device combination productsthe measurements of these interactions Covers how a drug-device combination product is developed, tested, and regulated Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes Table of ContentsFOREWORD vii PREFACE ix PART I BACKGROUNDS 1 1 Addressing Medical Device Challenges with Drug–Device Combinations 3 2 Historical Survey of Drug Delivery Devices 39 3 Development of Combination Product Drug Delivery Systems 66 4 Drug–Material Interactions, Materials Selection, and Manufacturing Methods 89 PART II PRODUCTS 117 5 Steroid-Releasing Lead 119 6 Thromboresistant Vascular Graft 142 7 Device-Enabled Drug Infusion Therapies 182 8 Promus Element Plus®: A Drug-Eluting Stent 214 9 Infuse® Bone Graft 241 INDEX 261
£124.40
John Wiley & Sons Inc Micro and Nanotechnologies in Engineering Stem
Book SynopsisThis book focuses on the latest advances in stem cells and tissue engineering using micro and nanotechnologies.Table of ContentsPreface xiii Contributors xv 1 Stem Cells and Nanotechnology in Tissue Engineering and Regenerative Medicine 1 1.1 A Brief History of Tissue Engineering and Regenerative Medicine, 1 1.2 Introduction to Stem Cells, 3 1.3 Tissue Engineering and Regenerative Medicine Strategies, 5 1.4 Nanotechnology in Regenerative Medicine and Tissue Engineering, 8 1.5 Conclusions, 19 2 Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering 27 2.1 Introduction, 27 2.2 Fabrication of Nanofibrous Scaffolds by Electrospinning, 30 2.3 Stem Cells: Type, Origin, and Functionality, 32 2.4 Stem Cell–Nanofiber Interactions in Regenerative Medicine and Tissue Engineering, 35 2.5 Conclusions, 44 3 Micro- and Nanoengineering Approaches to Developing Gradient Biomaterials Suitable for Interface Tissue Engineering 52 3.1 Introduction, 52 3.2 Classification of Gradient Biomaterials, 54 3.3 Micro- and Nanoengineering Techniques for Fabricating Gradient Biomaterials, 59 3.4 Conclusions, 70 4 Microengineered Polymer- and Ceramic-Based Biomaterial Scaffolds: A Topical Review on Design, Processing, and Biocompatibility Properties 80 4.1 Introduction, 80 4.2 Dense Hydroxyapatite Versus Porous Hydroxyapatite Scaffold, 85 4.3 Property Requirement of Porous Scaffold, 86 4.4 Design Criteria and Critical Issues with Porous Scaffolds for Bone Tissue Engineering, 88 4.5 An Exculpation of Porous Scaffolds, 90 4.6 Overview of Various Processing Techniques of Porous Scaffold, 92 4.7 Overview of Physicomechanical Properties Evaluation of Porous Scaffold, 95 4.8 Overview of Biocompatibility Properties: Evaluation of Porous Scaffolds, 104 4.9 Outstanding Issues, 107 4.10 Conclusions, 109 5 Synthetic Enroutes to Engineer Electrospun Scaffolds for Stem Cells and Tissue Regeneration 119 5.1 Introduction, 119 5.2 Synthetic Enroutes, 125 5.3 Novel Nanofibrous Strategies for Stem Cell Regeneration and Differentiation, 131 5.4 Conclusions, 135 6 Integrating Top-Down and Bottom-Up Scaffolding Tissue Engineering Approach for Bone Regeneration 142 6.1 Introduction, 142 6.2 Clinic Needs in Bone Regeneration Fields, 143 6.3 Bone Regeneration Strategies and Techniques, 144 6.4 Future Direction and Concluding Remarks, 151 7 Characterization of the Adhesive Interactions Between Cells and Biomaterials 159 7.1 Introduction, 159 7.2 Adhesion Receptors in Native Tissue, 160 7.3 Optimization of Cellular Adhesion Through Biomaterial Modification, 166 7.4 Measurement of Cell Adhesion, 170 7.5 Conclusions, 174 8 Microfluidic Formation of Cell-Laden Hydrogel Modules for Tissue Engineering 183 8.1 Introduction, 183 8.2 Cell-Laden Hydrogel Modules, 184 8.3 Cell Assay Systems Using Microfluidic Devices, 189 8.4 Implantable Applications, 191 8.5 Tissue Engineering, 194 8.6 Summary, 198 9 Micro- and Nanospheres for Tissue Engineering 202 9.1 Introduction, 202 9.2 Materials Classification of Micro- and Nanospheres, 204 9.3 Applications of Micro- and Nanospheres in Tissue Engineering, 205 9.4 Conclusions, 212 10 Micro- and Nanotechnologies to Engineer Bone Regeneration 220 10.1 Introduction, 220 10.2 Nano-Hydroxyapatite Reinforced Scaffolds, 221 10.3 Biodegradable Polymeric Scaffolds and Nanocomposites, 225 10.4 Silk Fibers and Scaffolds, 227 10.5 Summary, 231 11 Micro- and Nanotechnology for Vascular Tissue Engineering 236 11.1 Introduction, 236 11.2 Conventional Vascular Grafts, 237 11.3 Tissue-Engineered Vascular Grafts, 237 11.4 Micro- and Nanotopography in Vascular Tissue Engineering, 238 11.5 Micro- and Nanofibrous Scaffolds in Vascular Tissue Engineering, 241 11.6 Microvascular Tissue Engineering, 246 11.7 Conclusions, 253 12 Application of Stem Cells in Ischemic Heart Disease 261 12.1 Introduction, 261 12.2 Adult Skeletal Myoblast Cells, 267 12.3 Adult Bone Marrow–Derived Stem Cells, 269 12.4 Type of Stem Cells Used to Treat Cardiac Diseases, 273 12.5 Application, 277 12.6 Other Developing Technologies in Cell Engineering, 282 Acknowledgments, 293 References, 293 Index 303
£125.06
John Wiley & Sons Inc Bio and Multifunctional Polymer Architectures
Book SynopsisThis reference/text addresses concepts and synthetic techniques for the preparation of polymers for state-of-the-art usein biomedicine, synthetic biology, and bionanotechnology.Table of ContentsPreface xi Acknowledgments xiii 1 Introduction 1 1.1 What makes Polymers so Interesting? 1 1.2 Macromolecular Engineering and Nanostructure Formation 4 1.3 Specific Needs in Bionanotechnology and Biomedicine 5 Reference 6 2 Terminology 7 2.1 Polymer Architectures 7 2.2 Multifunctionality 11 2.3 Bioconjugates 12 2.4 Biocompatibility 12 2.5 Biodegradation 14 2.6 Bioactivity 14 2.7 Multivalency 15 2.8 Bionanotechnology 17 References 18 3 Preparation Methods and Tools 19 3.1 General Aspects of Polymer Synthesis 19 3.1.1 Chain Growth Polymerizations 20 3.1.2 Step Growth Polymerizations 23 3.1.3 Modification of Polymers 25 3.2 Controlled Polymer Synthesis 25 3.2.1 Anionic Polymerization 26 3.2.2 Cationic Polymerization 30 3.2.3 Controlled Radical Polymerization 34 3.2.4 Metal‐Catalyzed Polymerization 37 3.2.5 Chain Growth Condensation Polymerization 41 3.3 Effective Polymer Analogous Reactions 43 3.4 Pegylation 47 3.5 Bioconjugation 51 3.5.1 Polynucleotide Conjugates 53 3.5.2 Protein Conjugates 55 3.5.3 Polysaccharide Conjugates 57 3.6 Enzymatic Polymer Synthesis 59 3.7 Solid Phase Synthesis and Biotechnological Approaches 63 3.7.1 Solid Phase Synthesis 63 3.7.2 Biotechnology Approaches in the Synthesis of Biopolymers 75 3.8 Hydrogels and Hydrogel Scaffolds 81 3.8.1 Hydrogels 81 3.8.2 Hydrogels as Scaffold Materials 84 3.9 Surface Modification and Film Preparation 92 3.9.1 Self‐Assembled Monolayers 93 3.9.2 Langmuir–Blodgett Films 95 3.9.3 Layer‐by‐Layer Deposition 96 3.9.4 Immobilization by Chemical Binding to Substrates 97 3.9.5 Low‐Pressure Plasma 99 3.9.6 Electron Beam Treatment 101 3.10 Microengineering of Polymers and Polymeric Surfaces 102 References 107 4 Analytical Methods 113 4.1 Molecular Structure and Molar Mass Determination of Polymers and Biohybrids 113 4.1.1 Structural Characterization 114 4.1.2 Determination of Molar Mass and Molar Mass Distribution 132 4.2 Characterization of Aggregates and Assemblies 137 4.2.1 Dynamic Light Scattering 138 4.2.2 Pulsed Field Gradient and Electrophoretic Nuclear Magnetic Resonance 139 4.2.3 Field‐Flow Fractionation 142 4.2.4 UV–Vis Spectroscopy and Fluorescence Spectroscopy 144 4.2.5 Electron Microscopy 145 4.3 Characterization of Hydrogel Networks 147 4.3.1 Network Structure of Hydrogels 148 4.3.2 Swelling Degree 148 4.3.3 Mechanical Properties 150 4.3.4 Deriving Microscopic Network Parameters from Macroscopic Hydrogel Properties 153 4.4 Surface Characterization 154 4.4.1 X‐Ray Photoelectron Spectroscopy 154 4.4.2 Contact Angle Measurements by Axisymmetric Drop Shape Analysis 157 4.4.3 Electrokinetic Measurements 158 4.4.4 Spectroscopic Ellipsometry 159 4.4.5 Quartz Crystal Microbalance with Dissipation Monitoring 160 4.4.6 Surface Plasmon Resonance 161 4.4.7 Scanning Force Techniques 162 4.4.8 Environmental Scanning Electron Microscopy 164 4.5 Biophysical Characterization and Biocompatibility 166 4.5.1 Biophysical Characterization 167 4.5.2 Biocompatibility 175 References 183 5 Multifunctional Polymer Architectures 187 5.1 Multifunctional (Block) Copolymers 187 5.1.1 Multifunctionality through Copolymerization 187 5.1.2 Multifunctionality by Polymer Analogous Reactions 189 5.1.3 Spatially Defined Multifunctionality by Phase Separation and Self‐Assembly of Segmented Copolymers 190 5.2 Dendritic Polymers 196 5.2.1 Synthesis of Dendrimers and Hyperbranched Polymers 198 5.2.2 Properties and Applications 200 5.3 Glycopolymers 203 5.3.1 Linear Glycopolymers 205 5.3.2 Globular Glycomacromolecules 207 5.4 Peptide‐Based Structures 212 5.4.1 Hierarchical Self‐Assembly of Peptide Molecules 214 5.4.2 General Design Concepts for Peptide‐Based Structural Materials 215 5.4.3 Noncanonical Amino Acids in Peptide/Protein Engineering 217 5.4.4 Peptide‐Based Materials Inspired by Naturally Occurring Structural Proteins 217 5.4.5 Polypeptide Materials Based on other Naturally Occurring or De Novo Designed Self‐Assembling Domains such as Coiled Coils 221 5.4.6 Self‐Assembly of Short Peptide Derivates and Peptide‐Based Amphiphilic Molecules 222 5.5 Biohybrid Hydrogels 224 5.5.1 Composition Basic Principles and Formation of Biohybrids 225 5.5.2 Polynucleotide Biohybrids 228 5.5.3 Polypeptide or Protein Biohybrids 231 5.5.4 Polysaccharide Biohybrids 232 References 235 6 Functional Materials and Applied Systems 241 6.1 Organic Nanoparticles and Aggregates for Drug and Gene Delivery 241 6.1.1 Polymeric Micelles Polymersomes and Nanocapsules 241 6.1.2 Polymeric Beads and Micro/Nanogels Based on Dendritic Structures 254 6.1.3 Polyplexes for Gene Delivery 263 6.2 Polymer Therapeutics and Targeting Approaches 264 6.2.1 Current Status of Polymer Therapeutics 264 6.2.2 Implications and Rationale for Effective Delivery Systems 266 6.2.3 Cellular Uptake and Targeting 267 6.3 Multi‐ and Polyvalent Polymeric Architectures 271 6.3.1 Polyvalent Interactions on Biological Interfaces 272 6.3.2 Prospects for Multivalent Drugs 277 6.4 Bioresponsive Networks 280 6.4.1 Active Principle 280 6.4.2 Homeostatic Regulation of Blood Coagulation 281 6.4.3 Insulin Release in Response to Glucose Concentration 282 6.4.4 Urate‐Responsive Release of Urate Oxidase 283 6.4.5 Cell‐Responsive Degradation of Hydrogel Networks 284 6.5 Biofunctional Surfaces 284 6.5.1 Concepts and Aims of Biofunctional Material Surfaces 284 6.5.2 Biofunctional Surfaces for the Prevention of Biofouling 287 6.5.3 Anticoagulant Coatings for Blood‐Contacting Devices 292 References 295 Abbreviations 303 Index 309
£136.76
John Wiley and Sons Ltd Vascular Imaging of the Central Nervous System
Book SynopsisThe first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precisewith computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologistsespecially neuroradiologistshow to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potTable of ContentsList of Contributors, vii Preface, ix Acknowledgments, x Part One Ultrasound Vascular Imaging (UVI), 1 1 Basic Principles of Ultrasound Sonography, 3 Ana Maria Braz, Jaime Leal Pamplona and Joana N. Ramalho 2 Clinical Applications of Ultrasound Vascular Imaging, 14 Ana Maria Braz, Maria Madalena Patricio, and Joana N. Ramalho Clinical Vignette #1 – Occlusive dissection of the proximal primitive carotid artery with extension to the ICA, 29 3 Novel Applications of Ultrasound Vascular Imaging, 33 Elsa Irene Azevedo and Pedro Miguel Castro Clinical Vignette #1 – Indirect signs of carotid dissection, 60 Clinical Vignette #2 – A case of severe perfusion deficit and lack of cerebral vasoreactivity in spite of normal neurologic examination and cranial CT, 61 Part Two Computed Tomography Angiography (CTA), 67 4 Basic Principles of Computed Tomography Angiography (CTA), 69 Margareth Kimura and Mauricio Castillo Clinical Vignette # 1 – Revascularization procedure evaluation by CTA, 81 5 Intracranial Computed Tomography Angiography (CTA), 83 Isabel R. Fragata and Joana N. Ramalho Clinical Vignette #1 – Acute stroke, 105 Clinical Vignette #2 – Acute intracerebral hematoma, 105 6 Extracranial Computed Tomography Angiography (CTA), 110 Tiago Baptista and João Lopes Reis Clinical Vignette #1 – Carotid stenosis, 118 Part Three Magnetic Resonance Vascular Imaging (MRV), 125 7 Basic Principles of Time-of-Flight Magnetic Resonance Angiography (TOF MRA) and MRV, 127 Hugo Alexandre Ferreira and Joana N. Ramalho 8 Basic Principles of Phase Contrast Magnetic Resonance Angiography (PC MRA) and MRV, 137 Hugo Alexandre Ferreira and Joana N. Ramalho 9 Time-of-Flight Magnetic Resonance Angiography (TOF MRA) and MRV: Clinical Applications, 146 Mauricio Castillo, Juan Camilo Márquez, and Francisco José Medina 10 Phase Contrast Magnetic Resonance Angiography (PC MRA) and Flow Analysis: Clinical Applications, 161 Pedro Vilela Clinical Vignette #1 – PC MRA, 171 11 Contrast-Enhanced Magnetic Resonance Angiography (MRA): Fundamentals and Clinical Applications, 176 Khurram Javed and Mauricio Castillo Clinical Vignette #1 – Internal carotid artery stenosis quantifi cation, 183 12 Intracranial Magnetic Resonance Angiography (MRA), 1.5 T versus 3 T: Advantages and Disadvantages, 186 Sara Safder, Benjamin Huang, and Mauricio Castillo Clinical Vignette #1 – Questionable middle cerebral artery stenosis, 192 13 Time-Resolved Techniques, Basic Principles, and Clinical Applications, 194 Nuno Almeida, David Silva Monteiro, and Daniela Seixas Clinical Vignette # 1 – Occipital arteriovenous malformation (AVM), 204 Part Four Digital Subtraction Angiography (DSA), 207 14 Digital Subtraction Angiography (DSA): Basic Principles, 209 Mauricio Castillo Clinical Vignette #1 – Use of DSA in seizure patient, 219 15 Digital Subtraction Angiography (DSA) in Clinical Practice, 221 Yueh Z. Lee and Mauricio Castillo 16 Advanced and Future Digital Subtraction Angiography (DSA) Applications, 229 Pedro Vilela Clinical Vignette #1 – Digital subtraction angiography, 247 Part Five Brain Perfusion Techniques: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI), 255 17 Computed Tomography (CT) Perfusion: Basic Principles and Clinical Applications, 257 Joana N. Ramalho and Isabel R. Fragata Clinical Vignette # 1 – Acute stroke, 272 18 Dynamic Susceptibility Contrast-Enhanced MRI Perfusion: Basic Principles and Clinical Applications, 275 Francisco José Medina, Mauricio Castillo, and Juan Camilo Márquez 19 Arterial Spin Labeling (ASL) Perfusion: Basic Concepts, Artifacts, and Clinical Applications, 294 Debora Bertholdo and Mauricio Castillo Part Six Plaque Imaging, 307 20 Imaging of Carotid Plaque, 309 Sangam G. Kanekar Clinical Vignette #1 – Case examples, 332 Part Seven Intravascular Imaging, 345 21 Basic Concepts and Clinical Applications of Intravascular Imaging, 347 Hideki Kitahara, Peter J. Fitzgerald, Paul G. Yock, and Yasuhiro Honda Clinical Vignette #1 – Right internal carotid artery stenosis and left internal carotid artery occlusion, 368 Part Eight Pediatric Vascular Imaging, 371 22 Pediatric Vascular Imaging Techniques and Clinical Applications, 373 Carla R. Conceição, Rita Lopes da Silva and Joana N. Ramalho Clinical Vignette #1 – Use of CT and MRI in a pediatric patient, 401 Index, 405
£132.26
John Wiley and Sons Ltd Acne
Book SynopsisLearn to accurately diagnose, prevent and treat all three acnes using both traditional and novel approaches to understanding the causes and selecting the most effective treatments. Acne vulgaris is an extremely common condition. It is troublesome to manage, often persisting into middle age.Table of ContentsPreface ix Practical acne therapy xii Genetics xii Diet xii Hormones xii Stress xiii Comedones (plugs in pores) xiii Blemishes—a brief catalogue xiv Nodules xv Scars and sinuses xvi Support xvii Introduction xviii Nomenclature xix The three acnes and grading xx Acne vulgaris xx Acne rosacea xxii Acne inversa (hidradenitis suppurativa) xxiii Grading the three acnes xxvi Acne vulgaris xxvi Acne rosacea xxvi Acne inversa (hidradenitis suppurativa) xxvi 1 The three acnes and their impact 1 1.1 Acne vulgaris 1 1.1.1 Terminology 1 1.1.2 The starting point 3 1.2 Acne rosacea 3 1.2.1 The “pimply” part 4 1.2.2 The “redness” part 4 1.2.3 The third part the firm fibrosis 6 1.2.4 Part four—ocular rosacea 7 1.2.5 Putting it all together 7 1.2.6 The inflammatory epiphenomena in acne rosacea 8 1.2.7 The “acne rosacea” versus “rosacea” controversy 12 1.2.8 Summary 12 1.3 Acne inversa (formerly hidradenitis suppurativa) 12 1.3.1 Before the rupture where and why? 15 1.3.2 After the rupture what next? 15 1.3.3 So what invaders are important in acne inversa? 15 1.3.4 What makes this disease behave so much worse than acne vulgaris? 18 1.3.5 So what can one possibly do to settle down all this inflammation? 21 1.3.6 So how do you get rid of all this material? 25 1.3.7 What does the future offer? 25 1.4 The psychology of acne 26 1.4.1 Acne as a stress 26 1.4.2 Acne and self-image 27 1.4.3 Isotretinoin therapy and the psyche 27 1.4.4 The isotretinoin–depression question 28 1.4.5 Isotretinoin in perspective 29 2 The folliculopilosebaceous unit—the normal FPSU 31 2.1 Anatomy 31 2.2 Genetics 31 2.2.1 Acne vulgaris 31 2.2.2 Acne rosacea 34 2.2.3 Acne inversa/hidradenitis suppurativa (AI/HS) 34 2.2.4 The scottish twins 34 2.3 Epigenetics 35 2.3.1 The farmer’s boys 36 2.4 Embryology 36 2.5 Histology 38 2.5.1 Onwards and downwards 38 2.5.2 What is going on inside the FPSU? 40 2.6 Physiology 42 2.6.1 Hair first 42 2.6.2 Oil second 42 2.6.3 Last but definitely not least: the follicle 43 2.6.4 Looking deeper 44 2.7 Biochemistry 44 2.8 Hormones enzymes receptors and the intracrine system 45 2.8.1 The intracrine system 48 2.9 FoxO1 and mTORC1 49 2.9.1 The next step 50 2.9.2 The broad view 51 3 Pathogenetic mechanisms summarized 54 3.1 Acne vulgaris 54 3.2 Acne rosacea 56 3.3 Acne inversa/hidradenitis suppurativa (AI/HS) 57 3.4 Other variants 60 3.4.1 Malassezia folliculitis 60 3.4.2 Eosinophilic pustular folliculitis (ofuji’s disease) 62 3.4.3 Dissecting terminal folliculitis 63 3.4.4 Acne keloidalis 63 3.4.5 Epidermal growth factor receptor (EGFR) inhibitor eruption 64 3.4.6 Acné excoriée des jeunes filles 65 4 The acne hormones 67 4.1 The endogenous hormones 67 4.1.1 Androgens and their sources 67 4.1.2 Estrogens and their sources 68 4.1.3 Progesterone and the progesteroids 68 4.1.4 Insulin 69 4.1.5 Growth hormone and insulin-like growth factor-1 72 4.2 The exogenous hormones 72 4.2.1 Anabolic steroids 72 4.2.1.1 Mothers’ milk 72 4.2.1.2 Muscle makers 74 4.2.2 Oral contraceptive hormones 74 4.2.2.1 Oral estrogens 74 4.2.2.2 Oral progestins 75 4.2.2.3 Extended cycles 75 4.2.3 Other exogenous birth control hormones 77 4.2.3.1 Implants 77 4.2.3.2 Intrauterine devices 78 4.2.3.3 Intravaginal devices 78 4.2.3.4 Topicals: the patches 78 4.2.3.5 Intramuscular (depot) injections 78 4.2.4 Dietary sources of hormones 78 4.2.4.1 The impact of diet on acne 80 4.2.4.2 Carbohydrate load versus dairy load 83 5 Exogenous acnegens and acneform eruptions 87 5.1 Chemicals and medications 87 5.2 Endocrine imitators and disruptors 87 5.2.1 Environmental contamination 88 5.3 Foods 88 5.3.1 Iodine and bromine 89 5.3.2 Chocolate 89 5.3.3 Casein and whey 90 5.4 Photodamage glycation and the acne and aging processes 91 5.5 Smoking and nicotine 91 6 Follicular flora fauna and fuzz 93 6.1 Propionibacterium acnes (P. acnes) 93 6.1.1 Normal role of P. acnes 94 6.1.2 Pathogenic role of P. acnes 94 6.2 Malassezia species 95 6.2.1 Normal role 95 6.2.2 Immunogenicity 97 6.2.3 Pruritogenicity 98 6.2.4 Malassezia in the acnes 98 6.3 Staph strep and Gram-negative organisms 99 6.4 Demodex 99 6.5 Vellus hairs 101 7 The inflammatory response 103 7.1 Innate immunity 103 7.2 Adaptive (acquired) immunity 104 7.3 Inflammation as the primary acnegen 104 7.4 Mediators cellular and humoral and neuroimmunology 105 7.5 Allergy (shared antigens) 106 7.6 Inflammation pigment and PIH 106 7.7 Inflammation and scarring 107 8 Management 109 8.1 Prevention 109 8.2 General principles of management 111 8.3 Diet 111 8.3.1 Dairy 112 8.3.1.1 The deli-planning heiress 114 8.3.1.2 The pharmaceutical executive 115 8.3.2 Carbohydrates glycemic load and hyperinsulinemia 115 8.3.3 The paleolithic diet 116 8.3.4 High-fructose corn syrup (HFCS) 116 8.3.5 Metformin 116 8.3.6 Synthesis and summary 117 8.4 Comedolytics and other topicals 117 8.4.1 Standard topical comedolytics 118 8.4.1.1 Retinoids 118 8.4.1.2 Benzoyl peroxide 119 8.4.1.3 Salicylic acid 120 8.4.1.4 Alpha and beta-hydroxy acids 120 8.4.2 Unclassified topicals 120 8.4.2.1 Azelaic acid 120 8.4.2.2 Sulfur 121 8.4.2.3 Zinc compounds 121 8.4.2.4 Resorcinol 121 8.4.3 Systemic comedolytics 121 8.4.3.1 Vitamin A 121 8.4.3.2 Isotretinoin 121 8.4.3.3 Acitretin 127 8.4.3.4 Summary 128 8.5 Anti-inflammatories and antimicrobials 128 8.5.1 Antibiotics as anti-inflammatories 128 8.5.1.1 In acne vulgaris 128 8.5.1.2 In acne rosacea 129 8.5.1.3 In acne inversa 129 8.5.1.4 In dissecting terminal folliculitis (DTF) and acne keloidalis 129 8.5.2 Antibiotics as antibiotics 130 8.5.3 Ketoconazole ivermectin and crotamiton 130 8.5.3.1 In acne vulgaris 132 8.5.3.2 In acne rosacea 133 8.5.3.3 In acne inversa/hidradenitis suppurativa and dissecting folliculitis and cellulitis 135 8.5.4 Steroids 135 8.5.4.1 The marine 136 8.5.5 Nonsteroidal anti-inflammatory drugs (NSAIDs) and biologics 137 8.5.6 Phototherapy 137 8.5.7 Post-inflammatory hyperpigmentation 138 8.5.7.1 Prognosis 141 8.6 Hormone manipulations and therapy 141 8.6.1 Birth control pill selection 141 8.6.1.1 Estrogens 142 8.6.1.2 Progestins 143 8.6.2 Androgen receptor blockade 143 8.6.2.1 Spironolactone 144 8.6.2.2 Cyproterone acetate 146 8.6.2.3 Flutamide 146 8.6.2.4 Drospirenone 146 8.6.2.5 Topical androgen blockers 147 8.6.3 Dihydrotestosterone minimization 147 8.6.3.1 Finasteride 147 8.6.3.2 Dutasteride 147 8.6.3.3 Diet 148 8.6.4 Phototherapy–hormone interactions 149 8.7 Surgery 150 8.7.1 Acne vulgaris 150 8.7.1.1 Acne surgery for patients 150 8.7.1.2 Acne surgery for physicians 151 8.7.2 Acne rosacea 152 8.7.3 Acne inversa/hidradenitis suppurativa 153 8.7.3.1 Mini-unroofing by punch biopsy 153 8.7.3.2 Unroofing 154 8.7.3.3 Wide surgical excision 157 8.7.3.4 Healing options 158 8.8 Lights and lasers 162 8.8.1 Light and other radiation in acne 162 8.8.1.1 Radiation’s targets 163 8.8.1.2 Light as a practical acne therapy 164 8.8.2 Lasers 165 9 Acne in pregnancy 171 9.1 Epidemiology 171 9.2 Pathogenesis 172 9.3 Team up with mother nature 173 9.4 Targeting therapy 173 9.4.1 Clinical manifestations 173 9.4.2 Pathology 173 9.4.3 Diagnostic evaluation 173 9.4.4 Overview and general approach to treatment 174 9.4.5 Milk and pregnancy 174 9.4.6 Active therapy 175 9.4.6.1 Avoidance of harm 175 9.4.6.2 Lesion-directed therapy 177 9.4.6.3 Nonprescription topicals 177 9.4.6.4 Antimicrobials 177 9.4.6.5 Combination topicals 178 9.4.6.6 Anti-inflammatories 178 9.4.6.7 Hormone blockers 178 9.4.6.8 Procedural therapies 179 9.5 Discussion 179 9.6 Summary and conclusion 179 10 Putting it all together 182 10.1 Lifestyle choices and the acnes 182 10.1.1 The “processed cheese queen” 184 10.2 Therapeutic choices and the acnes 184 10.2.1 Acne vulgaris 184 10.2.2 Acne rosacea 185 10.2.3 Acne inversa/hidradenitis suppurativa 185 10.3 Conclusion 186 11 Appendices 187 11.1 Appendix A: the rosacea “classification and staging” controversy 187 11.2 Appendix B: the dairy versus carbohydrate controversy 189 12 The handouts 193 12.1 Acne 194 12.2 The “zero-dairy” diet 197 12.3 The risks and benefits of isotretinoin 199 12.4 The paleo diet 204 12.5 Acne inversa/hidradenitis suppurativa (AI/HS) 209 12.6 Yasmin/Ocella/Zarah or Yaz/Gianvi extended cycle for acne therapy 213 Index 215
£85.46
John Wiley and Sons Ltd Behavioral Dentistry
Book SynopsisBehavioral Dentistry, Second Edition, surveys the vast and absorbing topic of the role of behavioral science in the study and clinical practice of dentistry. An understanding of social sciences has long been a central part of dental education, and essential for developing a clinician's appreciation of human behavior as it affects efficient dental treatment. This book gathers together contributions from leading experts in each of the major subspecialties of behavioral dentistry. Its aim is not merely to provide the student and clinician with a comprehensive review of the impressive literature or discussion of the theoretical background to the subject, but also with a practical guide to adapting the latest techniques and protocols and applying them to day-to-day clinical practice. This second edition of Behavioral Dentistry discusses biobehavioral processes, including the psychobiology of inflammation and pain, oral health and quality of life, saliva health,Trade Review“An interesting read and a must-read for undergraduates needing to know more about behaviour techniques. For the established practitioner, if there are certain patient groups you see with behavioural quirks you wish to know more about, most likely this book will cover it.” (British Dental Journal, 11 July 2014) Table of ContentsContributors ix Foreword xiiiHenrietta L. Logan Preface xvDavid I. Mostofsky and Farida Fortune Part I Biobehavioral Processes 1 1 Cultural Issues in Dental Education 3Vishal R. Aggarwal and Farida Fortune 2 Oral Health and Quality of Life 11Marita R. Inglehart 3 Stress and Inflammation 27Annsofi Johannsen and Anders Gustafsson 4 Saliva in Health and Disease 37Mahvash Navazesh 5 Surface EMG Biofeedback in Assessment and Functional Muscle Reeducation 49Bruce Mehler 6 Hypnosis in Dentistry 75Bruce Peltier Part II Anxiety, Fear, and Pain 87 7 Environmental, Emotional, and Cognitive Determinants of Dental Pain 89Daniel W. McNeil, Alison M. Vargovich, John T. Sorrell, and Kevin E. Vowles 8 Cosmetic Dentistry: Concerns with Facial Appearance and Body Dysmorphic Disorder 109Ad De Jongh 9 Chronic Orofacial Pain: Biobehavioral Perspectives 121Samuel F. Dworkin and Richard Ohrbach 10 Chairside Techniques for Reducing Dental Fear 141Ronald W. Botto, Evelyn Donate-Bartfield, and Patricia Nihill 11 Sleep and Awake Bruxism 153Alan G. Glaros and Cody Hanson 12 Dental Fear and Anxiety Associated with Oral Health Care: Conceptual and Clinical Issues 165Daniel W. McNeil and Cameron L. Randall Part III Changing Behaviors 193 13 Behavior Management in Dentistry: Thumb Sucking 195Raymond G. Miltenberger and John T. Rapp 14 Management of Children’s Distress and Disruptions during Dental Treatment 209Keith D. Allen and Dustin P. Wallace 15 Stress, Coping, and Periodontal Disease 227Gernot Wimmer and Walther Wegscheider 16 Self-Efficacy Perceptions in Oral Health Behavior 237Anna-Maija Syrjälä 17 Drooling and Tongue Protrusion 251Jan J. W. Van der Burg, Robert Didden, and Giulio E. Lancioni Part IV Professional Practice 265 18 Listening 267Bruce Peltier 19 Interpersonal Communication Training in Dental Education 283Toshiko Yoshida and Kazuhiko Fujisaki 20 Biopsychosocial Considerations in Geriatric Dentistry 293Georgia Dounis and David Cappelli 21 Health Behavior and Dental Care of Diabetics 323Mirka C. Niskanen and Matti L. E. Knuuttila 22 Oral Health Promotion with People with Special Needs 337Paul Glassman 23 The Use of Humor in Pediatric Dentistry 349Ari Kupietzky and Joseph Shapira 24 Work Stress, Burnout Risk, and Engagement in Dental Practice 363Ronald C. Gorter 25 Role of Dentists as Oral Physicians in Physical and Mental Health 373Donald B. Giddon and Ruth Hertzman-Miller Appendix Brief Relaxation Training Procedure for Use in Dentistry 389Ronald W. Botto Index 397
£53.15
John Wiley and Sons Ltd Lasers in Dentistry
Book SynopsisLasers have become an increasingly useful tool in conventional dental practice. Their precision and less invasive quality make them an attractive technology in esthetic and pediatric dentistry, oral medicine, and a range of other dental procedures.Table of ContentsList of contributors vii Foreword xii Preface xiii Section 1: Basic principles of lasers and LEDs 1 Physics of lasers and LEDs: Basic concepts 3Clóvis Grecco, José Dirceu Vollet-Filho, Mariana Torres Carvalho, and Vanderlei Salvador Bagnato 2 High power lasers and their interaction with biological tissues 11Denise Maria Zezell and Patricia Aparecida Ana 3 Low power lasers: Introduction 19Maria Cristina Chavantes, Martha Simões Ribeiro, and Nathali Cordeiro Pinto 4 Cellular mechanisms of photobiomodulation 23Tiina I. Karu 5 Low level laser therapy – mechanism of action: Inflammatory process 27Jan Magnus Bjordal Rodrigo Alvaro Brandão Lopes-Martins and Lucio Frigo 6 Low level laser therapy – mechanism of action: Analgesia 34Roberta Chow 7 Antimicrobial photodynamic therapy in dentistry 40Felipe F. Sperandio, Caetano P. Sabino, Daniela Vecchio, Maria Garcia-Diaz, Liyi Huang, Ying-Ying Huang, and Michael R. Hamblin 8 Dosimetry 48Jan Tunér, Martha Simões Ribeiro, and Alyne Simões 9 Risk management and the safe use of laser technology 56Rosely Cordon and Dalva Cruz Laganá Section 2: Preventive, esthetic, and restorative dentistry 10 Selective caries removal, cavity preparation and adhesion to irradiated tissues 65Patricia Moreira de Freitas, Marcelo Giannini, Junji Tagami, and Simone Gonçalves Moretto 11 Management of non-carious cervical lesions 72Ana Cecilia Corrêa Aranha, Karen Müller Ramalho, and Marcella Esteves-Oliveira 12 Antimicrobial photodynamic therapy for carious tissue 80Giselle Rodrigues de Sant’Anna and Danilo Antônio Duarte 13 Treatment of internal ceramic surfaces 88Carlos de Paula Eduardo, Marina Stella Bello-Silva, and Paulo Francisco Cesar 14 Dental bleaching with LEDs and lasers 92Fátima Zanin, Aldo Brugnera Jr, and Mateus Cóstola Windlin 15 Caries diagnosis 104Mariana Minatel Braga, Thais Gimenez, Fausto Medeiros Mendes, Christopher Deery, and David N. J. Ricketts 16 Lasers in caries prevention 126Lidiany Karla Azevedo Rodrigues, Patricia Moreira de Freitas, and Marinês Nobre-dos-Santos Section 3: Endodontics 17 Bacterial reduction in root canals using antimicrobial photodynamic therapy 133Aguinaldo S. Garcez and Silvia C. Núñez 18 High power lasers in apical surgery 139Sheila C. Gouw-Soares, José Luiz Lage-Marques, and Cláudia Strefezza 19 High power lasers in endodontics 143José Luiz Lage–Marques, Sheila C. Gouw Soares, and Cláudia Strefezza Section 4: Periodontology 20 Surgical and non-surgical treatment of periodontal diseases 153Leticia Helena Theodoro and Valdir Gouveia Garcia 21 Antimicrobial photodynamic therapy in the treatment of periodontal diseases 159Valdir Gouveia Garcia and Letícia Helena Theodoro 22 Esthetic treatment of gingival melanin hyperpigmentation with the Er:YAG laser 166Daniel Simões A. Rosa and Akira Aoki Section 5: Oral surgery 23 Lasers in soft tissues surgeries 175Luciane Hiramatsu Azevedo, Marines Sammamed Freire Trevisan, and Ana Maria Aparecida de Souza 24 Implantodontology 179Juliana Marotti and Georgios E. Romanos 25 Bone biomodulation 196Antonio Luiz Barbosa Pinheiro, Aparecida Maria Cordeiro Marques, Luiz Guilherme Pinheiro Soares, and Artur Felipe Santos Barbosa 26 Use of low level laser therapy in lymphatic drainage for edema 207Luciana Almeida-Lopes and Attilio Lopes Section 6: Orthodontics and orofacial pain 27 Temporomandibular disorders 223Caroline Maria Gomes Dantas and Carolina Lapaz Vivan 28 Low level lasers in orthodontics 229Marinês Vieira S. Sousa 29 Traditional Chinese medicine and laser therapy 238Mario Pansini, Fabiano Augusto Sfier de Mello, and Andrea Malluf Dabul de Mello Section 7: Treatment of oral and facial lesions 30 Papilloma and fibroma 245Luiz Alcino Gueiros, Igor Henrique Silva, Lucia de Fátima Cavalcanti dos Santos, and Jair Carneiro Leão 31 Hemangioma and lymphangioma 248Luciane Hiramatsu Azevedo and Cláudia Strefezza 32 Non-neoplastic proliferative lesions or soft tissue tumor-like lesions of the oral cavity 253Vivian Cunha Galletta Kern, Edgar Kazuyoshi Nakajima, Rodrigo Ramos Vieira, and Luciane Hiramatsu Azevedo 33 Oral mucocele 261Luciana Corrêa and Luciane Hiramatsu Azevedo 34 Potentially malignant disorders of the oral mucosa 265Vivian Cunha Galletta Kern, Ana Claudia Luiz, Edgar Nakajima, Luciane Hiramatsu Azevedo, and Dante Antonio Migliari 35 Herpes 272Juliana Marotti 36 Recurrent aphthous ulcers 285Leila Soares Ferreira and Daiane Thais Meneguzzo 37 Burning mouth syndrome 290Lucia de Fátima Cavalcanti dos Santos and Jair Carneiro Leão 38 Nerve repair by light 293Felipe F. Sperandio, Ying-Ying Huang, Nivaldo Parizotto, and Michael R. Hamblin Section 8: Laser and antimicrobial photodynamic therapies in cancer patients 39 Optical diagnosis of cancer and potentially malignant lesions 305Cristina Kurachi, Lilian Tan Moriyama, and Alessandro Cosci 40 Low level laser therapy in the prevention and treatment of oral mucositis 321Alyne Simões, Fernanda de Paula Eduardo, Cesar A. Migliorati, and Mark M. Schubert 41 Cost-effectiveness of laser therapyin hospital practice 331Leticia Mello Bezinelli and Luciana Corrêa 42 Low Level Laser Therapy for hyposalivation and xerostomia 335Alyne Simões, Luana de Campos, Victor Elias Arana-Chavez, and José Nicolau 43 Antimicrobial photodynamic therapy in cancerpatients 340Luana de Campos, Cesar A. Migliorati, and Alyne Simões 44 Photodynamic therapy in cancer treatment 346Juliana Ferreira-Strixino and Elodie Debefve Index 351
£100.76
John Wiley & Sons Inc Biosurfaces
Book SynopsisIdeal as a graduate textbook, this title is aimed at helping design effective biomaterials,taking into account the complex interactions that occur at the interface when a synthetic material is inserted into a living system. Surface reactivity, biochemistry,substrates, cleaning, preparation, and coatings are presented, with numerous case studies and applications throughout. Highlights include: Starts with concepts and works up to real-life applications such as implantable devices, medical devices, prosthetics, and drug delivery technology Addresses surface reactivity, requirements for surface coating, cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processing strategies Table of ContentsChapter 1. Introduction to Biomaterials 1.1 Introduction 1.2 Summary Chapter 2. Tissue Interaction with Biomaterials 2.1 Introduction 2.2 Protein adsorption and Cell adhesion 2.3 Cell Migration 2.4 Controlled Cell Deposition 2.5 Extracellular Matrix 2.6 Biomineralization Chapter 3. Host Response of Implanted Biomaterials 3.1 Immune Response to Implanted Biomaterials 3.2 Transplant Immunology 3.3 Biocomaptibility Chapter 4. Fundamentals of Surface Modification 4.1 Introduction 4.2 Surface Properties of Biomaterials 4.3 Surface modifications 4.4 Applications Chapter 5. Multi Length Scale Hierarchy in Natural Materials 5.1 Introduction 5.2 Multi Length-scale Hierarchy 5.3 Human Bone 5.4 Turtle shell 5.5 Wood 5.6 Silk 5.7 Nacre 5.8 Gecko-feet 5.9 Lotus Leaf Chapter 6. Superhydrophobic Surfaces 6.1 Introduction 6.2 Surfaces and superhydrophobicity in nature 6.3 Classification of surfaces 6.4 Mechanics and nature of wetting 6.5 Fabrication of artificial superhydrophobic surfaces 6.6 Preparation of metallic superhydrophobic surfaces 6.7 Controlled wettability surfaces (CWS) 6.8 Conclusions Chapter 7. Surface Engineering and Modification for Biomedical Applications 7.1 Corrosion of Biomaterials and Need for Surface Coating for Biomedical Applications 7.2 Surface Reactivity and Body Cell Response 7.3 Key Requirements of Surface Coating 7.4 Key Biomaterial Substrates 7.5 Surface Preparation and Cleaning Techniques 7.6 Surface Engineering and Coating Techniques 7.7 Coatings for Biomedical Applications 7.8. Biosurface Characterization Chapter 8. Laser Engineering of Surface Structures 8.1 Introduction 8.2 Laser processing of biomaterials 8.3 Laser-based prototyping methods 8.4 Ultrafast laser pulses 8.5 Neural implants 8.6 Ophthalmic implants 8.7 Laser fabrication of cardiovascular devices 8.8 Laser-fabricated nanoscale materials 8.9 Two photon polymerization 8.10 Microneedle fabrication 8.11 Conclusions Chapter 9. Processing and Nanomechanical Properties of Hydroxyapatite-Nanotube Biocomposite 9.1 Introduction 9.2 Processing of HA-Carbon Nanotube Composites 9.3 Fracture Toughness and Tribological Properties of HA-Carbon Nanotube Composites 9.4 Adhesion of Bone Forming Cells on HA-CNT Surface 9.5 Biomechanical Compatibility at Bone/Coated Implant Interface 9.6 HA-Boron Nitride Nano Tube (BNNT) Composites 9.7 HA-TiO2 Nanotube Composites 9.8 Summary Chapter 10. Applications of Biomaterials 10.1 Multi-scale hierarchy in natural Bone 10.2 Coronary Stents 10.3 Medical Devices 10.4 Drug Delivery Chapter 11. Nanosafety, Nanosocietal and Nanoethical Issues 11.1 Governmental Environment and Health Safety Organization Protocols 11.2 Related Safety Hazards 11.3 Approach to Developing Safety Protocol for Laboratory Environment 11.4 Tendency of Nanoparticles 11.5 Current Capability of Nanoparticle Filters
£121.46
John Wiley and Sons Ltd Improving Mental Health Care The Global Challenge
Book SynopsisWritten by many of the world's leading practitioners in the delivery of mental health care, this book clearly presents the results of scientific research about care and treatment for people with mental illness in community settings.Trade Review"Pausing to thank Michele for a career of service, yielding improvements in many parts of the world, seems eminently worthwhile. We encourage all mental health services researchers to read this book (Fig. 1." (Acta Psychiatrica Scandinavica, 24 March 2014) “Nevertheless many of the contributors show a strong understanding of the impact of mental ill-health on people’s lives, a wish to reduce that impact, and awareness of and respect for people’s rights (even though legal aspects are not discussed, as I describe above). In other words, though you may agree or not with some of the contributors, their humanity shines through, and as such the book is a wonderful and fitting tribute to the pioneer of mental health community care, Michele Tansella.” (Potential Unleashed, 6 October 2013)Table of ContentsContributors xii Section 1 The global challenge 1 1 The nature and scale of the global mental health challenge 3 Mirella Ruggeri, Graham Thornicroft and David Goldberg 2 Scaling up mental health care in resource-poor settings 12 Shekhar Saxena, Benedetto Saraceno and Justin Granstein 3 The swings and roundabouts of community mental health: The UK fairground 25 Peter Tyrer 4 Mental health services and recovery 40 Mike Slade, Mary Leamy, Victoria Bird and Clair Le Boutillier Section 2 Meeting the global challenge 57 5 Implementing evidence-based treatments in routine mental health services: Strategies, obstacles, new developments to better target care provided 59 Antonio Lasalvia, Sarah Tosato, Katia De Santi, Doriana Cristofalo, Chiara Bonetto and Mirella Ruggeri 6 The need for new models of care for people with severe mental illnessin low- and middle-income countries 78 Ruben Alvarado, Alberto Minoletti, Elie Valencia, Graciela Rojas and Ezra Susser 7 The role of primary care in low- and middle-income countries 96 David Goldberg, Graham Thornicroft and Nadja van Ginneken 8 Meeting the challenge of physical comorbidity and unhealthy lifestyles 114 Lorenzo Burti, Loretta Berti, Elena Bonfioli and Irene Fiorini 9 Complex interventions in mental health services research: Potential, limitations and challenges 131 Thomas Becker and Bernd Puschner 10 The feasibility of applying the clinical staging paradigm to the care of people with mental disorders 145 Javier Vázquez-Bourgon, Luis Salvador-Carulla, Benedicto Crespo-Facorro and José Luis Vázquez-Barquero 11 Work, mental health and depression 163 Aart Schene, Hiske Hees, Maarten Koeter and Gabe de Vries 12 Training mental health providers in better communication with their patients 180 Christa Zimmermann, Lidia Del Piccolo, Claudia Goss, Giuseppe Deledda, Mariangela Mazzi and Michela Rimondini 13 Making an economic case for better mental health services 193 Martin Knapp Section 3 New research methods 209 14 Incorporating local information and prior expert knowledge to evidence-informed mental health system research 211 Luis Salvador-Carulla, Carlos Garcia-Alonso, Karina Gibert and Javier Vázquez-Bourgon 15 Innovative epidemiological methods 229 Francesco Amaddeo, Valeria Donisi, Laura Grigoletti and Alberto Rossi 16 Routine outcome monitoring: A tool to improve the quality of mental health care? 246 Sjoerd Sytema and Lian van der Krieke 17 Psychiatric case registers: Their use in the era of global mental health 264 Povl Munk-Jørgensen and Niels Okkels 18 Can brain imaging address psychosocial functioning and outcome in schizophrenia? 281 Marcella Bellani, Nicola Dusi and Paolo Brambilla 19 Statistics and the evaluation of the effects of randomised health-care interventions 291 20 Service user involvement in mental health research 308 Diana Rose Section 4 Delivering better care in the community 317 21 Psychotropic drug epidemiology and systematic reviews of randomised clinical trials: The roads travelled, the roads ahead 319 Andrea Cipriani, Michela Nosè and Corrado Barbui 22 Services for people with severe mental disorders in high-income countries: From efficacy to effectiveness 340 Paul Bebbington, Elizabeth Kuipers and David Fowler 23 The management of mental disorders in the primary care setting 374 Matteo Balestrieri 24 Some wobbly planks in the platform of mental health care 394 Norman Sartorius 25 Treatment gaps and knowledge gaps in mental health: Schizophrenia as a global challenge 403 Assen Jablensky Index 424
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