Description
Book SynopsisThis book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice.
The book:
- Discusses where drugs and devices work, where they fail, and when they need to work with each other
- Reviews interactions betweenhuman bodies and the drug-device combination productsthe measurements of these interactions
- Covers how a drug-device combination product is developed, tested, and regulated
- Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
Table of ContentsFOREWORD vii
PREFACE ix
PART I BACKGROUNDS 1
1 Addressing Medical Device Challenges with Drug–Device Combinations 3
2 Historical Survey of Drug Delivery Devices 39
3 Development of Combination Product Drug Delivery Systems 66
4 Drug–Material Interactions, Materials Selection, and Manufacturing Methods 89
PART II PRODUCTS 117
5 Steroid-Releasing Lead 119
6 Thromboresistant Vascular Graft 142
7 Device-Enabled Drug Infusion Therapies 182
8 Promus Element Plus®: A Drug-Eluting Stent 214
9 Infuse® Bone Graft 241
INDEX 261
