Medical research Books

Book SynopsisThis book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.Table of ContentsPart I Principles of Clinical Molecular DiagnosticsChapter 1 Molecules of Diseases and Their Detection Methods Chapter 2 Assay Performance Evaluation Chapter 3 Establishment of Biological Reference Interval Chapter 4 Ethics: Informed Consent, Patient Privacy Chapter 5 Bioinformatics Chapter 6 Report and Consultation Chapter 7 Factors Associated with Variation Chapter 8 Quality Control and Quality Assurance Chapter 9 Precision Medicine Part 2 Molecular Biomarkers and Signals from Diseased Functional Organ Chapter 10 Molecules in Body Systems Chapter 11 Molecules in Signal Pathways Chapter 12 Endocrine and Metabolism Chapter 13 Immune System Chapter 14 Lipoproteins Chapter 15 Transport and Carrier Proteins Chapter 16 Coagulation and Fibrinolysis Chapter 17 Cardiovascular System Chapter 18 Pregnancy Chapter 19 Urine Chapter 20 Bone Chapter 21 Cancer Chapter 22 Translation Research of Novel Biomarker Part 3 Advanced Molecular Diagnostic Techniques Chapter 23 Next-generation Sequencing (NGS) Chapter 24 Digital PCR Chapter 25 Biosensor Chapter 26 Microfluidic Chip Chapter 27 Liquid Biopsy Chapter 28 Molecular Targeted Imaging Chapter 29 Fluorescence in Situ Hybridization Chapter 30 Circulating DNA Quantification Chapter 31 DNA Methylation Detection Techniques Part 4 Disease Presentation and Clinical Laboratory Procedures Chapter 32 Immunological Disorders Chapter 33 Liver Diseases Chapter 34 Pancreatic Diseases Chapter 35 Digestive Tract Disease Chapter 36 Kidney Diseases Chapter 37 Cardiovascular Disease Chapter 38 Lung Disease Chapter 39 Blood Disorders Chapter 40 Endocrine and Metabolic Diseases Chapter 41 Neurological Disease Chapter 42 Reproductive Organ Cancer Chapter 43 Reproductive Organ Cancer Chapter 44 Transplant Matching Chapter 45 Paternity Test

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Book SynopsisContaining helpful summaries and checklists throughout and based on Mazur's thirty years of research experience, this accessible and informative guide will give all IRB members the tools they need to protect human lives and facilitate the research process.Trade ReviewA well-written and informative narrative of the inner workings of IRBs. It is a must-read for those who are (or will be) members of an IRB and for those who need to submit a proposal. -- Maura Pilotti, Ph.D. Metapsychology 2007 An indispensable guide for both experienced and inexperienced IRB members... I would recommend it to any IRB member. Doody's Review Service 2007 Mazur's book provides IRB members with essential questions they should ask when reviewing proposed and ongoing studies. -- Karen J. Maschke New England Journal of Medicine 2007 The book contains an interesting perspective and a wealth of knowledge. It contains quite a lot of information for any single audience, but those who serve on IRBs can benefit greatly from reading and referring to Mazur's work. -- Alice Z. Frohna JAMA 2007 College-level holdings strong in medical and research issues or medical ethics will want this review. Midwest Book Review 2007 There is much to like about Evaluating the Science and Ethics of Research on Humans; its depth and sophistication... Not just Mazur's experience but the overall evolution of research administration is reflected in this volume. -- Kenneth A. DeVille Journal of Legal Medicine 2007 Every IRB member must read this book so that the participants of clinical trials benefit from it. -- Sanjay A. Pai Indian Journal of Medical Ethics 2008 The author applies extensive experience to illustrate the depth of ethical reflection that research proposals can generate and provides guidance on how reflection can be directed to decision making... Checklists in the text and appendices afford IRB members and officers the comfort of knowing that little, if anything, has been overlooked in discharging ethics review. -- Bernard M. Dickens, PhD Annals of Internal Medicine 2008 The analysis of a study's risk-benefit ratio is especially good. U.S. Dept. of Energy, Office of Biological and Environmental Research 2007 Contains helpful summaries and checklists throughout based on the author's thirty years of research experience. Issues in Law and Medicine 2008Table of ContentsPrefaceIntroduction: What Can the New IRB Member Expect?Part I: The IRB, Its Work, and Its Challenges1. What Is an IRB, and What Does It Do?2. Basic Terms and Concepts Used in IRB Work3. What Is Risk?Part II: The Scientific Protocol and the Informed Consent Form4. Prescreening of Proposals5. The Scientific Protocol6. The Informed Consent Form7. Recruitment, Selection, and Compensation of Study Participants8. Research involving Questionnaires and Surveys9. Protection of Participants' Privacy in Research Dataand SpecimensPart III: The Continuing Work of the IRB10. The Ethical Issues of Informed Consent11. Continuing Review, Communication, and Feedback12. Where Are IRBs Making Mistakes, and How Can We Minimize Mistakes?13. Strategies for Managing the IRB Workload and Supporting IRB Decision Making14. Decision-Making Capacity and Accountability in ResearchSummary: The IRB's Key RoleAppendix 1: A Check List for Reviewing a Scientific ProtocolAppendix 2: A Check List for Reviewing an Informed Consent FormNotesWebsite References for Cited DocumentsIndex

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Book SynopsisMenopause affects 51% of the population. Yet despite increased awareness in recent years, so much of the menopause remains a mystery. Here, Dr Louise Newson, the UK's leading menopause specialist, breaks remaining taboos with the definitive guide to menopause. The Definitive Guide to the Perimenopause and Menopause starts with the key facts about hormones, their importance and their effects on our bodies, before delving into family histories and their effects on menopause, the essential guide to HRT, our libidos, our mental and physical health, how menopause affects our careers and relationships and so much more. Dr Louise Newson covers five key elements: 1. The essentials: must-know information that is evidence-based and accessible. 2. Exclusive research and findings from Dr Newson's non-profit Newson Health Research and Education and Balance community. 3. Common questions women want to know answered. 4. Real stories: Women share their own mTrade ReviewLouise is a voice you can really trust. I've learnt so much from her and now you can too. -- Holly WilloughbyDr Louise is a miracle worker -- Lorraine KellyLouise Newson is wonderful... a real expert in her field. -- Joe WicksDr Louise Newson is a fantastic authority on the menopause who has helped 100,000s of women through her clinics, digital products and books. Her tireless campaigning and expertly crafted content helps women around the world to better understand the menopause, make evidence based decisions and take control of their health. I recommend her work to all of my patients and colleagues. -- Dr Rupy Aujla, MBBS, BSc, MRCGP founder of "The Doctor's Kitchen"The medic who kickstarted the menopause revolution. -- Lorraine Candy, Journalist * The Sunday Times *Louise has brought the conversion about the menopause to the foreground much to the relief of lots of women and is championing adequate availability of adequate hormone replacement as well as advocating healthy lifestyle -- Miss Claire Mellon, Consultant Obstetrician and GynaecologistDr Louise Newson is an experienced GP and one of a few top UK experts on the menopause who has helped hundreds of thousands of women through her clinic, app and websites. This book should help many more! -- Professor Tim SpectorIt is impossible to overstate the pioneering role Dr Louise Newson has played in bringing menopause education to public awareness. I found this impassioned and comprehensive book so instructive. Readers are incredibly lucky to get the benefit of her decades of expertise. -- Tamsen Fadal, Journalist, Menopause Advocate, Podcaster

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Book SynopsisThis book demonstrates how qualitative methods can be used to address research issues pertinent to mental health practice and psychotherapy. With contributions from leading researchers, the book examines how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to approach ethical issues.Trade Review“In a field that at times feels dominated by obfuscating jargon and a cult-like zeal, the editors have produced an accessible, illuminating text that will be of great value to those wishing to gain an introduction to this essential and developing area of mental health research.” (The British Journal of Psychiatry, 1 May 2012) "David Harper and Andrew Thompson’s book Qualitative Research Methods in Mental Health and Psychotherapy provides a reference for students and practitioners who are using qualitative research to explore topics related to mental health. The book provides a rich and comprehensive text, with contributions from specialized authors on a number of key themes and research methods relevant to qualitative research. Despite being specifically aimed at those researching mental health issues, this text would be useful for any student or practitioner who wishes to get to grips with ‘big q research’..." (Feminism and Psychology, 2013) “Since receiving this book for review, I have found myself repeatedly recommending it to fellow doctoral researchers from a range of professional backgrounds, at all stages of candidature. I do so because, in my opinion, this book addresses, in an accessible, clear, yet thorough manner, the issues which all students and practitioner-researchers face in aspiring to produce high quality, creative, qualitative research in mental health and psychotherapy.” (QMiP Bulletin Issue 15, Spring 2013) Table of ContentsAbout the Contributors. Acknowledgements. PART I Getting Started. 1 Introduction (Andrew R. Thompson and David Harper). 2 Identifying and Synthesizing Qualitative Literature (Rachel L. Shaw). 3 Ethical Issues in Qualitative Mental Health Research (Andrew R. Thompson and Eleni Chambers). 4 Participation and Service User Involvement (Alison Faulkner). 5 Qualitative Data Collection: Asking the Right Questions (Hannah Frith and Kate Gleeson). 6 Qualitative Methods for Studying Psychotherapy Change Processes (Robert Elliott). 7 Choosing a Qualitative Research Method (David Harper). PART II Methods. 8 Interpretative Phenomenological Analysis in Mental Health and Psychotherapy Research (Michael Larkin and Andrew R. Thompson). 9 Existentialist-Informed Hermeneutic Phenomenology (Carla Willig and Abigail Billin). 10 Grounded Theory Methods for Mental Health Practitioners (Alison Tweed and Kathy Charmaz). 11 Discourse Analysis (Eugenie Georgaca and Evrinomy Avdi). 12 Narrative Psychology (Michael Murray and Sally Sargeant). 13 Ethnomethodology/Conversation Analysis (Mark Rapley). 14 Q Methodological Research in Mental Health and Psychotherapy (Wendy Stainton Rogers and Phillip O. Dyson). 15 Thematic Analysis (Helene Joffe). PART III Establishing Good Quality Qualitative Research in Mental Health. 16 In Pursuit of Quality (Liz Spencer and Jane Ritchie). 17 Emerging Issues and Future Directions (David Harper and Andrew R. Thompson). Index.

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Book SynopsisHypotheses are fundamental to all sciences, including medicine. They play a critical role in motivating the development of science, since interesting and important hypotheses foster the diversity and debate upon which the scientific process depends. It is necessary to learn and understand how to assess a process, realise and discuss details and consequently launch a hypothesis. This book offers a number of novel, non-mainstream hypotheses in various states of development from authors with relevant expertise and experience.

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Book SynopsisSarcoidosis is a multisystem granulomatous disease of unknown etiology. It can occur at all ages, with the incidence peaking at 20 to 40 years. This book reviews the epidemiology, etiology, pathology, clinical manifestations, diagnosis and management strategies of sarcoidosis, while highlighting recent studies that have provided new insights into this unique and debilitating disease. The authors also specifically point out the urological manifestations of sarcoidosis to avoid misdiagnoses and to provide early intervention.

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Book SynopsisTrade Review...the book has much to commend it to qualifying practitioners, their tutors and practice educators.—The British Journal of Social Work...[the authors] offer credible practice-researchable examples from social work, nursing, physical therapy, education, and other practice contexts and the application of multiple methods to answer questions that emanate from those fields of practice. How do they know all this stuff?—Journal of Social WorkTable of ContentsPreface1. An Introduction to Practitioner Research2. Orientation3. Focusing4. Planning5. Data Collection6. Analysis and Conclusion7. Design and Innovation8. Documentation and PresentationAppendix. Using SourcesIndex

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Book SynopsisWhat if everything you know about salt is wrong? A leading cardiovascular research scientist explains how this vital crystal got a negative reputation, and shows how to lower blood pressure and experience weight loss using salt. The Salt Fix is essential reading for everyone on the keto diet!   We’ve all heard the recommendation: eat no more than a teaspoon of salt a day for a healthy heart. Health-conscious Americans have hewn to the conventional wisdom that your salt shaker can put you on the fast track to a heart attack, and have suffered through bland but “heart-healthy” dinners as a result.    What if the low-salt dogma is wrong?    Dr. James DiNicolantonio has reviewed more than five hundred publications to unravel the impact of salt on blood pressure and heart disease. He’s reached a startling conclusion: The vast majority of us don’t need t

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Book SynopsisMolecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences.Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the reader up to date with specific topics in cancer research, how the topics give rise to development of new informatics and statistics tools, and how the tools can be applied. The focus of the book is to give the reader an understanding of keyTable of ContentsPREFACE ; 1. Association Studies ; 2. Methods for DNA Copy Number Derivations ; 3. Methods for Derivation of LOH and Allelic Copy Numbers Using SNP Arrays ; 4. Bioinformatics of gene expression and copy number data integration ; 5. Analysis of DNA Methylation in Cancer ; 6. Pathway Analysis: Pathway Signatures and Classification ; 7. Two Methods for Comparing Genomic Data Across Independent Studies in Cancer Research: Meta-analysis and Oncomine Concepts Map ; 8. Bioinformatic Approaches to the Analysis of Alternative Splicing Variants in Cancer Biology ; INDEX

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisTrade Review".good, practical guide to a complex subject." Dave Bennett, CBRA".[Rothe] introduces methods of inquiry and draws on his considerable research experience to guide potential researchers. His expositions of the sometimes confusing world of qualitative inquiry are entertaining, thorough and accurate." -Jeffrey E. Nash, Department of Sociology and Anthropology, Southwest Missouri State University

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Book SynopsisThis book integrates philosophy of science, data acquisition methods, and statistical modeling techniques to present readers with a forward-thinking perspective on clinical science. It reviews modern research practices in clinical psychology that support the goals of psychological science, study designs that promote good research, and quantitative methods that can test specific scientific questions. It covers new themes in research including intensive longitudinal designs, neurobiology, developmental psychopathology, and advanced computational methods such as machine learning. Core chapters examine significant statistical topics, for example missing data, causality, meta-analysis, latent variable analysis, and dyadic data analysis. A balanced overview of observational and experimental designs is also supplied, including preclinical research and intervention science. This is a foundational resource that supports the methodological training of the current and future generations of clinicTrade Review'The editors have produced an indispensable tome. For the first time, the various methods and approaches used by clinical psychology researchers have been brought together. This book represents a watershed moment in the development of clinical psychology as a scientific discipline and belongs on the bookshelves of all clinical psychologists.' Robert F. Krueger, Distinguished McKnight University Professor, University of Minnesota'This handbook provides a much-needed primer on a range of methods important for clinical science. It would be an excellent addition to a graduate introductory course on methods in clinical science or a very useful resource for more advanced researchers wanting to learn about new approaches and methods in the field.' Deanna M. Barch, Chair and Professor of Psychological and Brain Sciences, Washington University, St Louis'Assembled by two highly respected clinical scientists, this handbook is current, comprehensive, and sophisticated. Researchers across a wide spectrum of experience will find this volume invaluable to their work. Written by leading experts, the chapters discuss methodological and quantitative approaches to address clinical psychology's most pressing questions.' Josh Miller, Professor and Director of Clinical Training, University of Georgia'This comprehensive treatment of the cutting-edge methods and procedures used in the rapidly evolving field of clinical research should be a go-to resource for anyone interested in the state-of-the-art in the discipline of clinical psychology. Topics as diverse as latent variable models, molecular genetics, functional imaging, and the replication crisis all receive clear and detailed consideration.' Leslie C. Morey, George T. and Gladys H. Abell Professor, Texas A&M UniversityTable of ContentsSection I. Clinical Psychological Science: An Evolving Field: 1. Trends in the evolving discipline of clinical psychology; 2. Defining and refining phenotypes: operational definitions as open concepts; 3. Building models of psychopathology spanning multiple modalities of measurements; Section II. Observational Approaches: 4. The conceptual foundations of descriptive psychopathology; 5. Survey and interview methods; 6. Psychometrics in clinical psychology research; 7. Latent variable models in clinical psychology; 8. Psychiatric epidemiology methods; Section III. Experimental and Biological Approaches: 9. Conceptual foundations of experimental psychopathology: historical context, scientific posture, and reflections on substantive and method matters; 10. A practical guide for designing and conducting cognitive studies in child psychopathology; 11. Peripheral psychophysiology; 12. Behavioral and molecular genetics; 13. Concepts and principles of clinical functional magnetic resonance imaging; 14. Reinforcement learning approaches to computational clinical neuroscience; Section IV. Developmental Psychopathology and Longitudinal Methods: 15. Studying psychopathology in early life: foundations of developmental psychopathology; 16. Adolescence and puberty: understanding the emergency of psychopathology; 17. Quantitative genetics research strategies for studying gene-environment interplay in the development of child and adolescent psychopathology; 18. Designing and managing longitudinal studies; 19. Measurement and comorbidity models for longitudinal data; Section V. Intervention Approaches: 20. The multiphase optimization strategy for developing and evaluating behavioral interventions; 21. Future directions in developing and evaluating psychological interventions; 22. Health psychology and behavioral medicine: methodological issues in the study of psychosocial influences on disease; Section VI. Intensive Longitudinal Designs: 23. Ambulatory assessment; 24. Modeling intensive longitudinal data; 25. Modeling the individual: bridging nomothetic and idiographic levels of analysis; 26. Social processes and dyadic designs; 27. Models for dyadic data; Section VII. General Analytic Considerations: 28. Reproducibility in clinical psychology; 29. Meta-analysis: integration of empirical findings through quantitative modeling; 30. Mediation, moderation, and conditional process analysis: regression-based approaches for clinical research; 31. Statistical inference for causal effects in clinical psychology: fundamental concepts and analytical approaches; 32. Analyzing nested data: multilevel modeling and alternative approaches; 33. Missing data analyses; 34. Machine learning for clinical psychology and clinical neuroscience.

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Book SynopsisThe go-to guide for graduate students and professionals in research methods and research design in clinical psychology. Comprehensive, and with examples drawn from topics of general interest and various disciplines, this fully revised and updated edition presents the latest principles and practices of how to conduct scientific research.Trade Review'Dr. Kazdin's Research Design in Clinical Psychology (6th edition) is the perfect textbook to help students develop skills in and appreciation for sound research design. Research Methods is often the course that students dread, finding the material dry and inaccessible, but Dr. Kazdin's approach to balancing scientific rigor with humor will make the material come alive for students. He provides numerous examples to guide students in understanding why certain methods are needed and when they are appropriate.' Arielle Baskin-Sommers, Yale University'A wonderful approach to research design, successfully leading students and faculty to focus upon those underlying critical questions. An important subject which can be overwhelming for many becomes alive and intriguing, if not fascinating. This sixth edition utilizes visionary real-life examples to bring home underlying and often complex concepts.' Pat DeLeon, University of Hawaii'This invaluable text approaches methodology as a 'way of thinking' to help students see the challenge and excitement of designing solid, useful psychological research. Rather than marching through a checklist of research designs, Kazdin provides a principle-based approach to help students understand the rationale and reasoning behind selection of specific empirical approaches. No one approach is centered, as Kazdin recognizes the value of using different lenses to study the complexity of human behavior. Thank you, Dr. Kazdin, for this updated, useful resource.' J. Gayle Beck, University of Memphis'Science is a way of knowing how the world and the people in it work, free of the biases, distortions, and prejudices so prevalent today. In this, the sixth edition of Research Design in Clinical Psychology by Alan Kazdin, one finds the most comprehensive, lucid, and useful description of the various scientific methods applicable in clinical psychology in a well-written, well-organized, and easy-to-digest presentation. From the initial step of developing an idea, through randomized controlled trials, single case experimental designs, as well as observational and qualitative methods, and accompanied by review questions and key comments, students and established researchers alike will find everything they need to engage in meaningful research. There is good reason this book has become the gold standard.' David H. Barlow, Boston University'Research Design in Clinical Psychology is required reading for anyone interested in conducting clinical research. I learned how to design research studies using this book and I still use it to this day as a reference to guide my work and that of my students and trainees. It's comprehensive, incredibly clear, and the updates in this new edition make this a must-have book.' Matthew K. Nock, Harvard University'Alan Kazdin is one of the great minds of our generation. His intellectual and empirical leadership has placed him at the summit of clinical psychological science, and this sixth edition of Research Design in Clinical Psychology nicely illustrates his contributions as teacher and sensei. Written with clarity, style, and wit, the book provides a soup-to-nuts guide to the research process. It starts with the basic question of why we even need science, explains what is needed for valid inference, describes diverse research designs and ways to analyze data, and offers characteristically wise perspectives on ethics and scientific integrity. This volume is an ideal text for clinical science students and an invaluable reference for the rest of us!' John Weisz, Harvard University'A clinical psychology graduate course on research methods would be incomplete without this book. The latest edition evolves in content and scope, adapting research methods to a dynamic scientific landscape. Kazdin is prepared like no other scholar to show students how to design studies that accurately characterize the mental health phenomena that manifest in a diverse, rapidly changing world.' Andres De Los Reyes, University of MarylandTable of ContentsPreface; About the author; 1. Introduction; 2. Drawing valid inferences I: internal and external validity; 3. Drawing valid inferences II: construct and data-evaluation validity; 4. Ideas that begin the research process: sources and guiding concepts; 5. Experimental research: group designs; 6. Control and comparison groups in experiments; 7. Observational research: case-control and cohort designs; 8. Single-case experimental research designs; 9. Qualitative and mixed methods research; 10. Assessment: selecting measures for research; 11. Assessment: types of measures and their use; 12. Special topics of assessment; 13. Data evaluation: null hypothesis significance testing; 14. Data evaluation: presenting and analyzing the data; 15. Data interpretation: cautions, 'negative results' and replication; 16. Ethical issues and guidelines for research; 17. Scientific integrity; 18. Communication of research findings; 19. Closing comments: guidelines for a well (and quickly) designed study; Glossary; References; Name index; Subject index.

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Book SynopsisThis book integrates philosophy of science, data acquisition methods, and statistical modeling techniques to present readers with a forward-thinking perspective on clinical science. It reviews modern research practices in clinical psychology that support the goals of psychological science, study designs that promote good research, and quantitative methods that can test specific scientific questions. It covers new themes in research including intensive longitudinal designs, neurobiology, developmental psychopathology, and advanced computational methods such as machine learning. Core chapters examine significant statistical topics, for example missing data, causality, meta-analysis, latent variable analysis, and dyadic data analysis. A balanced overview of observational and experimental designs is also supplied, including preclinical research and intervention science. This is a foundational resource that supports the methodological training of the current and future generations of clinicTrade Review'The editors have produced an indispensable tome. For the first time, the various methods and approaches used by clinical psychology researchers have been brought together. This book represents a watershed moment in the development of clinical psychology as a scientific discipline and belongs on the bookshelves of all clinical psychologists.' Robert F. Krueger, Distinguished McKnight University Professor, University of Minnesota'This handbook provides a much-needed primer on a range of methods important for clinical science. It would be an excellent addition to a graduate introductory course on methods in clinical science or a very useful resource for more advanced researchers wanting to learn about new approaches and methods in the field.' Deanna M. Barch, Chair and Professor of Psychological and Brain Sciences, Washington University, St Louis'Assembled by two highly respected clinical scientists, this handbook is current, comprehensive, and sophisticated. Researchers across a wide spectrum of experience will find this volume invaluable to their work. Written by leading experts, the chapters discuss methodological and quantitative approaches to address clinical psychology's most pressing questions.' Josh Miller, Professor and Director of Clinical Training, University of Georgia'This comprehensive treatment of the cutting-edge methods and procedures used in the rapidly evolving field of clinical research should be a go-to resource for anyone interested in the state-of-the-art in the discipline of clinical psychology. Topics as diverse as latent variable models, molecular genetics, functional imaging, and the replication crisis all receive clear and detailed consideration.' Leslie C. Morey, George T. and Gladys H. Abell Professor, Texas A&M UniversityTable of ContentsSection I. Clinical Psychological Science: An Evolving Field: 1. Trends in the evolving discipline of clinical psychology; 2. Defining and refining phenotypes: operational definitions as open concepts; 3. Building models of psychopathology spanning multiple modalities of measurements; Section II. Observational Approaches: 4. The conceptual foundations of descriptive psychopathology; 5. Survey and interview methods; 6. Psychometrics in clinical psychology research; 7. Latent variable models in clinical psychology; 8. Psychiatric epidemiology methods; Section III. Experimental and Biological Approaches: 9. Conceptual foundations of experimental psychopathology: historical context, scientific posture, and reflections on substantive and method matters; 10. A practical guide for designing and conducting cognitive studies in child psychopathology; 11. Peripheral psychophysiology; 12. Behavioral and molecular genetics; 13. Concepts and principles of clinical functional magnetic resonance imaging; 14. Reinforcement learning approaches to computational clinical neuroscience; Section IV. Developmental Psychopathology and Longitudinal Methods: 15. Studying psychopathology in early life: foundations of developmental psychopathology; 16. Adolescence and puberty: understanding the emergency of psychopathology; 17. Quantitative genetics research strategies for studying gene-environment interplay in the development of child and adolescent psychopathology; 18. Designing and managing longitudinal studies; 19. Measurement and comorbidity models for longitudinal data; Section V. Intervention Approaches: 20. The multiphase optimization strategy for developing and evaluating behavioral interventions; 21. Future directions in developing and evaluating psychological interventions; 22. Health psychology and behavioral medicine: methodological issues in the study of psychosocial influences on disease; Section VI. Intensive Longitudinal Designs: 23. Ambulatory assessment; 24. Modeling intensive longitudinal data; 25. Modeling the individual: bridging nomothetic and idiographic levels of analysis; 26. Social processes and dyadic designs; 27. Models for dyadic data; Section VII. General Analytic Considerations: 28. Reproducibility in clinical psychology; 29. Meta-analysis: integration of empirical findings through quantitative modeling; 30. Mediation, moderation, and conditional process analysis: regression-based approaches for clinical research; 31. Statistical inference for causal effects in clinical psychology: fundamental concepts and analytical approaches; 32. Analyzing nested data: multilevel modeling and alternative approaches; 33. Missing data analyses; 34. Machine learning for clinical psychology and clinical neuroscience.

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Book SynopsisThis book provides new research insights on rare diseases. Chapter One reviews the use of patients'' registries as a key tool in rare disease management. Chapter Two discusses the worldwide experience with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with rare abdominal and pelvic neoplasms with peritoneal metastases that should be evaluated for long-term benefit. Chapter Three explores the contribution of psychology-related research on Congenital Anomalies (CAs) from the analysis of international scientific literature.

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Book SynopsisThe chapters in this volume present the latest developments in medicine and biology. The overuse and everyday abuse both in humans and animals, in conjunction with the decreased production of new antimicrobial drugs during the last years, have led to the limitation of the treatment choices and the development of antibiotics resistance as discussed in Chapter One. Chapter Two reports on the overuse of antibiotics as a serious public health problem, and the clear correlation between their use and the emergence of resistant bacterial strains both at the individual and populace levels. Chapter Three discusses how antibiotics play a major role in the treatment of infectious diseases; however, there is evidence that they are also used for non-indicated viral conditions. Chapter Four studies pharmacovigilance which is the science relating to the collection, detection, assessment and prevention of adverse reactions and other problems associated with drugs. Chapter Five reviews adverse events associated with ibrutinib with an emphasis on infections, bleeding, and atrial fibrillation. In general, as a method of treatment of GH patients with frequent relapses (more than 6 times a year), Chapter Six recommends individual therapy combining etiotropic chemotherapy and additional immunotherapy with the IFN drugs and IFN inducers developed in Russia Chapter Seven evaluates current research findings on the measurement resolution of the most commonly used dehydration markers, their applicability in combat sports research and the potential health-related risks of excessive hypohydration. Chapter Eight discusses peritonectomy using electrosurgical dissection with a ball-tip as a new methodology for obtaining control of peritoneal metastases.

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Book SynopsisThis book provides readers with the latest developments in neurosciences research. Chapter One reports on how neural network learning is possible in patients who are not conscious including patients in the vegetative state. Chapter Two is written for educational therapists who are working with ASD cases and the aim is twofold. Firstly, it is to raise the awareness among educational therapists on current neuroscientific studies on the autistic brain and its ASCs (and hence, ASD). Secondly, it is to inform how the findings from these neuroimaging studies can be translated into praxiological implications in autism treatment plan design for educational therapists. Chapter Three studies the postoperative cognitive dysfunction (POCD) in patients after cardiac surgeries along with extensive review of the literature in this field. At least three types of POCD may be outlined, and therefore tests sensitive to each type of POCD should be included into test batteries. Chapter Four discusses the common types of brachial plexus injuries, local anatomy, exam findings, classification systems for injury severity, diagnostic tests and management. Chapter Five integrates the results of prior publications and describes additional findings and further implications providing indications that these intra- and intermuscular sequencing patterns are referenced to the cross-system relevance of efficient movement coordination in general, interlocking the whole range from intersegmental motor interactions down to the functional structures within specific muscles, as one functional entity. Chapter Six reports on strabismus which is the most frequent ocular surgery performed in childhood and requires anaesthesia that provides akinesia, analgesia, and sometimes ocular hypotonia, to adjust sutures. Chapter Seven studies the poster dorsal medial amygdala (MePD) which is involved in the display of reproductive behaviour in both male and female rats. Further studies demonstrated that it also integrates a subcortical social behaviour network with additional, but selective modulatory roles.

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Book SynopsisThis book provides readers with the latest developments in neurosciences research. Chapter One summarized the progress of this area over the past two decades by showing that inflammatory mediators (ligands in a positive feedback loop and/or other inflammatory mediators through receptor cross-talk) released from inflamed or injured tissues increase cell surface trafficking of nociceptive receptors in primary sensory neurons and dorsal horn neurons. The aim of Chapter Two is to discuss and detail well-established stress animal models, discussing their validity to mimic human neuropsychiatric disorders (i.e. depression, anxiety and cognitive deficiency). Chapter Three discusses post-dural puncture headache (PPH) which is the most common major complication following neuraxial anaesthesia and usually happens in obstetrics. Chapter Four reviews the known pharmacological mechanisms of action of first- and second-generation synthetic cathinones in the central nervous system in comparison to those of cocaine and amphetamines. These studies of the efficacy of Cognitive Behaviour Therapy in adults with ADHD are reviewed in Chapter Five. As reported in Chapter Six, adult hippocampal neurogenesis is mediated by many factors and plays an important role in several diseases, such as Alzheimer disease, stroke, depression and epilepsy. In Chapter Seven, cognitive maps characteristics and the brain systems involved in spatial navigation of cognitive maps are the main focus. Chapter Eight reports on the improvement of human cognition and its precision due to technological advancement within the field of neuroscience. Chapter Nine demonstrates that low concentrations of N-acyl dopamines (below 1 am) stimulate cell proliferation, intermediate ones (1-20 gm.) induce differentiation, and higher ones lead to apoptosis.

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Book SynopsisThis book is a continuation of the book Medicine Researcher Biographical Sketches and Research Summaries which compiles biographical sketches of top professionals in the field of medicinal research, as well as research summaries from a number of different focuses in this important field.

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Book SynopsisIn the first chapter of Horizons in World Cardiovascular Research. Volume 14, the secondary mechanical complications of acute coronary syndrome are discussed while presenting initial treatment methods by way of pharmacology. These complications typically occur swiftly (acute phase and subacute phase) and they originate in the severe cardiac expansion zones, in border regions with the healthy tissue as well as the infarcted tissue. The second chapter explains that preeclampsia, a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation, is a major complication in pregnancy, occurring in 7-10% of all pregnant women, and is one of the major causes of maternal morbidity and mortality, preterm birth, intrauterine growth restriction (IUGR), and perinatal mortality. The author explores the way in which markers of endothelial dysfunction could be used to predict hypertensive disorders in pregnancy. The third chapter examines modern percutaneous technologies for the controlling of valvular heart disease, with the goal of pinpointing new opportunities for research. Additionally, the utility of various emerging balloon valvuloplasty techniques, MitraClip, and valve-in-valve approaches are explained in the hopes that understanding their limitations might aid in new research. Molecular domains in heart muscles in family members are classified in the fourth chapter, with the intention of ascertaining the effect of vasodilator agents, sugar, and hypoxia on the operation of protein domains. The domains inside the heart aorta and vein of a slaughtered domestic pig are studied to ascertain how acetylsalicylic acid (ASA), ramipril, sugar, heat and physical exertions influenced them. Next, research on the link between family history of depression and atherosclerotic coronary artery disease is presented in the fifth chapter. Depression is one of the leading contributors to the global burden of diseases, and is one of the major risk factors for cardiovascular disease, therefore it is essential to develop a link between how genetics and inheritance in families may worsen the prognosis of cardiovascular disease in offspring. The sixth chapter supports the claim that ivabradine should be the primary pharmacologic treatment for patients with symptoms of inappropriate sinus tachycardia by ruling out other possible causes.

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Book SynopsisThis book is a continuation of the book Medicine Researcher Biographical Sketches and Research Summaries which compiles biographical sketches of top professionals in the field of medicinal research, as well as research summaries from a number of different focuses in this important field.

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Book SynopsisDuring the 115th Congress, several bipartisan bills were introduced that aimed to expand the number of telehealth services that are covered under Medicare. Telehealth is the electronic delivery of a health care service via a technological method. Health care providers use telehealth to improve patients access to and quality of care. Under Medicare, these patients are likely to live in rural areas, be under the age of 65 and be disabled. The first chapter in this book examines legislation as it relates to expanding telehealth services, including the five conditions that a telehealth service must meet to be covered and paid for under Medicare Part B. The second chapter focuses on the background and key issues surrounding biologics and biosimilars. Biologics and biosimilars frequently require special handling (such as refrigeration) and processing to avoid contamination by microbes and other unwanted substances. Also, they are usually administered to patients via injection or infused directly into the bloodstream. For these reasons, biologics often are referred to as specialty drugs. The cost of specialty drugs, including biologics, can be extremely high. The next chapter is a two-page report on a recent experiment in the United States using the gene modification tool CRISPR to target a disease gene in human embryos which raised optimism about promising medical advances, generated scientific debate as well as renewed debate about longstanding ethical issues. The fourth chapter provides a brief history of FDA drug regulation, describes FDAs early risk management programs, and focuses on the agencys current risk management authorities, specifically risk evaluation and mitigation strategies (REMS). The chapter also discusses issues that have arisen as a result of REMS, particularly the impact on generic drug competition. The last chapter of this book addresses frequently asked questions about government and private-sector policies that affect drug prices and availability. Among the prescription drug topics covered are federally funded research and development, regulation of direct-to-consumer advertising, legal restrictions on reimportation and federal price negotiation.

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Book SynopsisMany cancers are associated with the abnormal production of some molecules which can be measured in plasma/urine or can be detected on the surface of resected tumour tissue. These molecules are known as tumour markers. The potential uses of tumour markers are screening in the general population, differential diagnoses of symptomatic patients, clinical staging of cancer, estimating tumour volume, indicating prognosis, monitoring treatment and detecting recurrences. In order to obtain maximum clinical benefit, a tumour marker should have some characteristics. A tumour marker should be tissue-specific. The plasma level of the tumour marker should be in proportion to the size and activity of the tumour. A tumour marker should be present in plasma at a detectable level, even though tumour size is very small. A tumour marker should reflect the altered tumour characteristic as a response to therapy. Unfortunately, currently used tumour markers do not meet all of these criteria. A majority of them are present in normal, benign and tumour tissues, and unfortunately, they are not specific enough to be used for cancer screening in the general population. In addition, conventional tumour markers are poor in reflecting altered tumour behavior in response to anticancer therapy. They are of most value during follow-up appointments. Recent developments in molecular biology have led to the identification of numerous new tumour biomarkers. Firstly, the detection of DNA and RNA freely circulating in blood has provided a new perspective for the early diagnosis of cancer, patient follow-up, and assessment of therapy efficacy. Circulating free nucleic acids can originate from both malignant and non-malignant tissues. Discrimination of tumour cells is based on the presence of tumour-specific genetic and epigenetic alterations. This circulating nucleic acid-based approach is termed a liquid biopsy. Due to its non-invasive and repeatable features, liquid biopsy is a promising tool for cancer patients. It is particularly helpful in cancers where solid tissue biopsies are not feasible, and in the metastatic patients when multiple distinct tumour masses are simultaneously present. As another advantage, liquid biopsy shows the current tumour dynamics during anticancer therapy and drug sensitivities that conventional examinations fail to reflect. Secondly, self-renewable stem cells have the potential to cause cancer. If stem cells are genetically or epienetically changed, their differentiation potential becomes impaired and their proliferative capacity becomes uncontrolled. Current anticancer therapies mostly fail to eradicate cancer stem cells and instead favor expansion of the cancer stem cell pool and/or select for resistant stem cells. Thirdly, microRNAs, non-coding RNAs and transfer RNA fragments found in the bloodstream are candidate markers for the diagnosis and prognosis of different types of cancer. This book provides an overview of these new molecular tumour markers.

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Book SynopsisIn the opening chapter of Advances in Medicine and Biology. Volume 135, the authors propose that to correctly interpret the results of procalcitonin accuracy studies for the diagnosis of neonatal sepsis, we must analyze the methods we use to measure procalcitonin performance. Trypanosoma cruzi is a flagellated protozoan that causes Chagas disease, also known as America Trypanosomiasis. The authors discuss techniques for diagnosis, including parasitological methods based on microscopy, xenodiagnoses and microscopic examination of fresh anticoagulated blood or buffy coat. The collection goes on to discuss rhabdomyolysis, a clinical syndrome caused by injury to skeletal muscle fibres with the release of their breakdown products, especially myoglobin, into the circulation. The condition is associated with traumatic injury, crush syndrome, extreme exercise, drugs, toxins and malignant hyperthermia among other things. In the next review, the authors intend to aid our understanding of lipid metabolism and provide a rational basis for future research in drug development by analysing current data related to the role of mutual regulation between hormone-sensitive lipase and insulin, discussing unanswered questions in different lines of studies. Following this, one study aims increase the activity of high-molecular-weight heparin through the development of a new high active heparin complex with glutamate. The thermodynamic simulation of chemical equilibria based on pH data and the molecular dynamics simulation were used. Later, the structure of two human blood groups with both AB active glycoproteins (HOC 89 and Cyst 19) isolated from human ovarian cyst fluids are introduced. Their properties are characterized by interactions with mAbs against the human blood group (ABH), Lewis system, sialyl glycotopes and various applied lectins. This collection also reviews differential diagnostic considerations to consider when making a diagnosis of malignant peripheral nerve sheath tumors in the breast. Malignant peripheral nerve sheath tumors account for approximately 5% of all soft tissue sarcomas and are associated with neurofibromatosis type I and a prior history of radiation. They are aggressive tumors with a propensity to recur and to develop distant metastases. An analysis is provided concerning the literature regarding the clinicopathologic features of epithelioid malignant peripheral nerve sheath tumors. Particular attention is paid to how this variant may be differentiated from other diagnostic considerations and on the utility of molecular testing in the evaluation of these lesions. Finnish type congenital nephrotic syndrome, also known as type 1 nephrotic syndrome (NPHS1), OMIM 256300, is caused by mutations in the nephrin gene. These mutations cause a congenital glomerulonephritis, which is particularly frequent in Finland (incidence of 1:8200 newborns). Since immunosuppressive therapy does not induce clinical remission, the authors propose that the best method of treatment is a bilateral nephrectomy and kidney transplantation. In the subsequent chapter, the effect of advanced glycation end products on renal cell in diabetic nephropathy is discussed in respect to downstream alterations such as reactive oxygen species production, activation of nicotinamide adenine dinucleotide phosphate oxidase, nuclear factor-kappa B activation, synthesis of transforming growth factor-beta 1 and fibronectin leading to epithelial to mesenchymal transition. In the concluding chapter, the potential problem of quinoline yellow as food additive is introduced, followed by detailed description of the electrochemical methods of detection. Quinoline yellow is commonly applied as a food colorant, however it may cause allergy symptoms in those allergic to aspirin and lead to severer hyperactivity in children.

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Book SynopsisIn Advances in Medicine and Biology. Volume 138, the authors reflect on the development of ethically reliable procedures that keep in line with cultural traits while guaranteeing proper implementation of the fundamental principles of bioethics, within the framework of ethically binding biomedical research. As such, this write-up gives an overview on the ethical implications and regulatory issues governing African traditional medicine research practices in Cameroon.This collection goes on to present the relationship between riboflavins chemical properties and its exploitable applications in both living organisms and analytical assays. Riboflavin, popularly known as Vitamin B2 or Vitamin G, was historically the second identified vitamin and presents itself as a yellow solid substance, and its higher stabilization is observed at pH 5.In the following study, technological discrimination of lactic acid bacteria species isolated from fermented cereal foods available in Abidjan are presented as of interest, because these species are used as starter cultures to optimize fermented product quality. The sugar fermentation pattern and identity of twenty-three lactic acid bacteria isolates were carried out by using a ApiwebTM/Api50 CHL test kit. Protease, amylase, and bacteriocins production as well as growth parameters after 18h culture are performed.Topical naltrexone therapy has been reported to reverse diabetes complications in type 1 and type 2 animal models in an effective and non-toxic manner. Because of this, the authors discuss the mechanism of action of naltrexone, as well as data documenting its efficacy in therapy for diabetic complications, supporting the repurposing of naltrexone for clinical use.Additionally, general opioid receptor antagonists such as naltrexone that block classical opioid receptors mu, delta, and kappa are still widely used to reverse drug and alcohol overdose/use. With the discovery of the opioid growth factor receptor axis as a novel biological pathway involved in homeostasis of replicating cells and tissues, the role of opioid receptor antagonists is expanded.Syndecans are transmembrane heparan sulfate proteoglycans expressed in a variety of cells, and their heparan sulfate glycosaminoglycan side chains bind to several proteins (such as chemokine and growth factors) taking on various biological roles. Several types of proteoglycans, including syndecans in the lung as components of extracellular matrices, were previously recognized only as molecular glue that supports the structure of tissues. However, growing evidence suggests that proteoglycans have a variety of biological activities such as control of inflammation, wound healing, development and homeostasis, which the authors examine.M-type phospholipase A2 receptor is a type I transmembrane receptor and belongs to the mannose receptor family. In 2009, M-type phospholipase A2 receptor was identified as a target intrinsic antigen in most cases of primary membranous nephropathy. The authors propose that in addition, the detection of circulating anti-M-type phospholipase A2 antibodies is useful not only for the differential diagnosis of primary membranous nephropathy but also for monitoring treatment, including after renal transplantation.The most frequent familial amyloidosis presentation is due to transthyretin, a protein analyzed in the concluding chapter and originally referred to as pre-albumin. There are more than eighty transthyretin mutations, the majority being amyloidogenic. The carriers of the mutation on this protein genes show a clinical heterogeneous amyloidosis according to the nature of aminoacid substitution.

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Book SynopsisIn the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines. The chapter will also discuss the outcomes of Palliative Medicine in Oncology focusing on the improvements in patient clinical and quality of life outcomes. Next, a systematic chapter aims to better explain the mechanisms that underlie electrolyte disturbances in cancer patients, to stress on the serious prognostic implications involved and to provide practical and useful indications for the prompt diagnosis, management and therapy of electrolyte disorders. The authors discuss over thirty Pt{Î2-P(X)nP}Cl2 (n = 5,6,7,8) derivatives in which organodiphosphines create wide varieties of the metallocyclic rings: eight-membered (PC5P, PC2OC2P, PC2NC2P), nine-membered (PC6P, POC4OP), ten-membered (POC5OP, PC2OCOC2P, PC3OC3P), and eleven-membered (PC8P, PNC6NP, POC6OP). Another included study covers eighty five Pt(II) complexes with an inner coordination sphere of cis- PtP2Cl2. The P- donor ligands are organodiphosphines which create four- and five-membered metallocyclic rings with the PCP, PNP, PC-CP, PC=CP, PN2P and PCOP types. In the penultimate chapter, the authors examine over forty cis-Pt(Î2-PXXXP)Cl2 derivatives in which organodiphosphines create six-membered metallocyclic rings, and the concluding chapter examines over thirty cis-Pt(Î2-PXXXXP)Cl2 derivatives in which organodihosphines create seven-membered metallocyclic rings.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/new-developments-in-oncology-research/

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Book SynopsisThis reference book equips readers with cutting-edge information on the many advances in diagnostic and therapeutic treatments for human diseases that have been made in recent years, with examples from laboratory medicine. Diagnostic procedures and treatment protocols are a critical part of the health care system, providing dynamic information that influences provider decisions with respect to disease prevention, diagnosis, treatment procedures, and management of the disease. With advances in medical technologies over the past few decades, diagnostics have become even more essential to the practice of medicine for personalised diagnosis and treatment. Developments in health care technologies have extended the survival prospects of persons all over the globe. Once serious conditions have become considerably easier to manage and even cure in numerous cases. Constant laboratory investigations in the health sciences have expanded the quality of treatment, life-expectancy, as well as the quality of life for patients. In this book, readers will find a detailed discussion of new methodologies in treating diseases, including 3D technology, and prediction of chronic diseases using computation techniques, which provide promising avenues for the diagnosis, treatment, and prophylaxis of diseases.

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Book SynopsisThis book represents current findings on the impact of oxidative stress in the pathogenesis of diseases and underlying mechanisms of antioxidants influencing health and disease processes. The book is divided into seven sections that describe how antioxidants defend oxidative stress-mediated diseases as well as recent developments, future opportunities, and challenges. Sections 1 analyses the role of oxidative stress in aging and associated diseases as well as the use of antioxidants in health maintenance, preventing and repairing injuries caused by oxidative stress. Section 2 represents the status of various antioxidants in cigarette smoking and antioxidant defense against exercise-induced oxidative stress. Section 3 focuses on the effect of oxidative stress in the pathogenesis of neurodegeneration and the existing status of antioxidant therapy. Section 4 covers the impact of oxidative stress at different levels of chronic degenerative diseases, as well as treatment with antioxidants to revert and diminish the cellular injury. Section 5 offers the importance of antioxidants in abating the pathological processes involved in hypertension and stroke. Section 6 presents the complexity associated with oxidative stress and metabolic disorders as well as the potential of antioxidants used in amelioration of related pathologies. Section 7 discusses the antioxidant defense against oxidative stress-mediated erectile dysfunctions and the significance of antioxidants in pregnancy. The book represents the copious set of specific research updates and diaphanous understanding of oxidative stress-mediated cellular damages and role of antioxidants in disease processes from experienced and eminent academicians, researchers, and scientists from throughout the world. Suitable for professionals, academicians, students, researchers, scientists and industrialists around the world in the biomedical, health, and life science fields.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/oxidativestressandantioxidantdefensebiomedicalvalueinhealthanddiseases/

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Book SynopsisMastitis is the most widespread and economically important disease of dairy cattle occurring throughout the world. It is of particular concern for farmers in developing countries like India. The economic loss due to mastitis is associated with reduced milk production, discard of milk due to antibiotic residues, treatment and management costs, and occasional deaths. The menace has a serious zoonotic threat due to shedding of bacteria and their toxins through the milk. Mastitis is caused by a wide spectrum of pathogens and, it is categorized into contagious and environmental mastitis. The major contagious pathogens include Staphylococcus aureus, Streptococcus agalactiae, Mycoplasma spp. and Corynebacterium bovis. The environmental mastitis can be induced by those pathogens residing in the environment such as E. coli, Klebsiella spp., Streptococcus dysgalactiae and Streptococcus uberis. On the basis of symptoms, mastitis can be classified into either clinical or sub-clinical. Clinical mastitis is characterized by sudden onset, alterations of milk composition and appearance, decreased milk production, and the presence of the cardinal signs of inflammation in the udder. In contrast, in sub-clinical mastitis, no cardinal signs are detected although the milk production is decreased and the somatic cell count is increased. The diagnosis of sub-clinical mastitis is a real challenge in the dairy industry. The book contains a total of 7 chapters including a research chapter (chapter 6) for control of mastitis, a global problem with public health menace. Persons associated with antimicrobial stewardship and drug control policies may go through chapters 5 and 7 for getting some suggestions and clarifications for their consideration. The use of propolis for mastitis control is an innuendo for the reduction of antimicrobial misuse. Antimicrobial resistance (AMR) in pathogens isolated from ewes and goats with mastitis has been recorded. This approach is in line with the antimicrobial stewardship, with the aim of limiting the selection for antimicrobial resistant strains. Propolis ethanol extracts showed a good bactericidal activity against mastitis pathogens as well as the capacity to inhibit biofilm formation and to disrupt established biofilm. These results strongly suggest that propolis may be part of a mastitis control strategy. The present book is a comprehensive attempt to cover the relevant topics of bovine mastitis such as physiology of milk secreation with associated biomarkers, immune responses of udder, updated etiology, current trends in conventional treatment and management, prospect of herbal preparations and propolis as supportive treatment options. The book will cater the need of the veterinary/dairy science/one health students, professionals, researchers and moreover, the progressive farmers who wish to understand the basics of the menace. Any suggestions from any corner for the improvement of the book will be gladly acknowledged.Table of ContentsDedicationPrefaceBasic Understandings of MastitisPhysiology of Milk Secretion and Its Alteration during Mastitis with Related BiomarkersImmune Responses of Mammary GlandBovine Mastitis: Etiology & Epidemiology, Current Trends and Future Perspectives in Monitoring, Detection, and TreatmentsThe Commonly Used Drugs for Conventional Therapy of MastitisThe Use of Propolis for Mastitis ControlSupportive Herbal Preparations with Antimicrobial Drugs for Treatment of MastitisAbout the Editor and AuthorsIndex.

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Book SynopsisThe incidence of cancer is alarmingly increasing worldwide. The major problem that the medical profession is currently facing refers to "late presentation" patients who, for the most part, have reached the terminal stage of the illness. For these people, the only treatment option left is palliative care. Various patterns of palliation have been in practice in every culture and in every ethnic group for generations. Unfortunately, we still lack significant and sustained investment in research related to the practice of palliative care. Authors from around the globe seek more investment of public and private funds to investigate ways to improve the bedside practice of palliative care. Modern palliative care concepts were established by Dame Cicely Saunders, from London, UK, right after World War II. It is only in the past 15 to 20 years that this new discipline started to develop in the developing world. However, we still lack the essential basic biological processes involved in relieving the suffering of cancer patients while receiving palliative measures throughout the trajectory of the disease. This book owes its origins in large measure to physicians and nurses in 30 countries globally, who decided to devote their time, energy, compassion and goodwill, to the promotion of palliative care in their countries and communities, yet they lack solid evidence-based data to rely upon while extending their treatment to both patients and family members. The goal, in part, is to bridge the gap between scientists and clinicians from developed countries and those in developing countries. We have been aware of the variances between cultures, traditions, beliefs and practices. I am continually struck by the seemingly diametrical views of "knowing" and cultures and the strong overlaps that might give rise to new ideas. We hope that these new volumes will serve to inspire health professionals'' and administrators'' interests and appreciation for the investment in basic and clinical research that will serve to advance our understanding of the underlying physical and emotional factors involved while extending palliative care to patients suffering from cancer and other non-communicable illnesses.

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Book SynopsisThe incidence of cancer is alarmingly increasing worldwide. The major problem that the medical profession is currently facing refers to "late presentation" patients who, for the most part, have reached the terminal stage of the illness. For these people, the only treatment option left is palliative care. Various patterns of palliation have been in practice in every culture and in every ethnic group for generations. Unfortunately, we still lack significant and sustained investment in research related to the practice of palliative care. Authors from around the globe seek more investment of public and private funds to investigate ways to improve the bedside practice of palliative care. Modern palliative care concepts were established by Dame Cicely Saunders, from London, UK, right after World War II. It is only in the past 15 to 20 years that this new discipline started to develop in the developing world. However, we still lack the essential basic biological processes involved in relieving the suffering of cancer patients while receiving palliative measures throughout the trajectory of the disease. This book owes its origins in large measure to physicians and nurses in 30 countries globally, who decided to devote their time, energy, compassion and goodwill, to the promotion of palliative care in their countries and communities, yet they lack solid evidence-based data to rely upon while extending their treatment to both patients and family members. The goal, in part, is to bridge the gap between scientists and clinicians from developed countries and those in developing countries. We have been aware of the variances between cultures, traditions, beliefs and practices. I am continually struck by the seemingly diametrical views of "knowing" and cultures and the strong overlaps that might give rise to new ideas. We hope that these new volumes will serve to inspire health professionals'' and administrators'' interests and appreciation for the investment in basic and clinical research that will serve to advance our understanding of the underlying physical and emotional factors involved while extending palliative care to patients suffering from cancer and other non-communicable illnesses.

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Book SynopsisThoracic lymphadenopathy consists of mediastinal and/or hilar lymphadenopathy. Thoracic lymph nodes are anatomically one of the most complex groups of the lymphatic network in the body and describing them could be nerve wracking if there is no proper understanding of the locations, its systemic divisions and its significance in diseased states. Thoracic lymphadenopathy is one of the most common radiological findings seen on the CT scan of thorax. The incidence of these findings have particularly increased in the era of lung cancer screening with low dose CT scan of the chest. The differential diagnosis for mediastinal and hilar lymphadenopathy is broad and spans from being reactive to benign disease to lung cancer or metastatic cancer. In this book, we have tried to simplify the lymph node stations based on the latest IASLC guidelines, done a very comprehensive review about mediastinal and hilar lymphadenopathy in different disease states and provided the pathway to diagnosis. This book also gives a detailed account of noninvasive testing including CT chest and PET CTs. This book also discusses in detail the advanced endoscopic and non-endoscopic procedures like EBUS-TBNA, EUS and Mediastinoscopy that we have at our disposal for the diagnosis of thoracic lymphadenopathy. The indications, contraindications, sensitivity and specificity of each procedure is discussed in detail.Table of ContentsDedicationPrefaceAnatomy of Mediastinal and Hilar Lymph NodesLung CancerMetastatic CancersLymphomaInfectious DiseasesSarcoidosisInterstitial and Occupational Lung DiseasesMiscellaneous Disorders Affecting Thoracic Lymph NodesRole of EBUS/EUS in the Diagnosis of Mediastinal and Hilar LymphadenopathyMediastinoscopy for the Diagnosis of Mediastinal and Hilar LymphadenopathyAbout the EditorIndex.

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