Biology, life sciences Books

Book SynopsisConnecting past, present, and future instrument development and use, Biocalorimetry: Foundations and Contemporary Approaches explores biocalorimetry's history, fundamentals, methodologies, and applications. Some of the most prominent calorimeter developers and users share invaluable personal accounts of discovery, discussing innovative techniques as well as special and original applications. Wide in scope, the book also covers calorimetry use on membranes, nucleic acids, and proteins and addresses both thermodynamics and kinetics. The book begins with a look at the historical development of calorimeters needed for biological research. It then describes advanced approaches that use high-quality commercial calorimeters to study biochemical and other biological processes. It also shows how novel experimental designs and data analysis procedures are applied to proteins, DNA, membranes, and living matter. Trade Review"This is a highly specialized collection of articles mainly by European chemists, biochemists, and biologists. The article topics surround the history, theory, and application of calorimetry in biology. The measurement of heat absorbed and exuded by matter, due to changes in surrounding temperature, forms the science of relevance to characterize the materials; this can be related to their structures and properties. Historically, calories have been defined as units of heat energy. The focus of several chapters includes the problem of measuring the very small amounts of heat specific to biological matter, which requires very sensitive and sophisticated instruments. In four sections, the articles cover the history and methods of calorimetry, the use of differential scanning and isometric titration calorimetry to characterize specific membranes, the calorimetry of nucleic acids and proteins, and applications of calorimetry to other areas, such as clinical samples, enzymes, and pharmaceuticals. Every article is replete with references, graphs, and mathematical analysis. The index is useful.Summing Up: Recommended. Graduate students, researchers, professionals."—N. Sadanand, Central Connecticut State University, in the January 2017 issue of CHOICE"Whether the reader is new to the area or already an experienced scientist, this book will serve as the ultimate reference in the field of biocalorimetry. The very pioneers that gave us the instrumentation and techniques cover the history and background of biocalorimetry. The ongoing research is described by current experts in different fields of biocalorimetry. Everything is there."—Arne Schön, Research Scientist, Department of Biology, Johns Hopkins University"This book is a much-needed update on the field of biothermodynamics and biocalorimetry. It starts with historical and sometimes personal views from some of the pioneers of this field, followed by reviews on the state of the art of calorimetry application to the study of biomembranes, nucleic acids, and proteins, as well as biomedical applications. I think all newcomers should take the time to read the book from its beginning to grasp how the field started and until the end to have an idea on where it is expanding to."—Watson Loh, Professor of Physical Chemistry, Institute of Chemistry, University of Campinas"This is a highly specialized collection of articles mainly by European chemists, biochemists, and biologists. The article topics surround the history, theory, and application of calorimetry in biology. The measurement of heat absorbed and exuded by matter, due to changes in surrounding temperature, forms the science of relevance to characterize the materials; this can be related to their structures and properties. Historically, calories have been defined as units of heat energy. The focus of several chapters includes the problem of measuring the very small amounts of heat specific to biological matter, which requires very sensitive and sophisticated instruments. In four sections, the articles cover the history and methods of calorimetry, the use of differential scanning and isometric titration calorimetry to characterize specific membranes, the calorimetry of nucleic acids and proteins, and applications of calorimetry to other areas, such as clinical samples, enzymes, and pharmaceuticals. Every article is replete with references, graphs, and mathematical analysis. The index is useful.Summing Up: Recommended. Graduate students, researchers, professionals."—N. Sadanand, Central Connecticut State University, in the January 2017 issue of CHOICE"Whether the reader is new to the area or already an experienced scientist, this book will serve as the ultimate reference in the field of biocalorimetry. The very pioneers that gave us the instrumentation and techniques cover the history and background of biocalorimetry. The ongoing research is described by current experts in different fields of biocalorimetry. Everything is there."—Arne Schön, Research Scientist, Department of Biology, Johns Hopkins University"This book is a much-needed update on the field of biothermodynamics and biocalorimetry. It starts with historical and sometimes personal views from some of the pioneers of this field, followed by reviews on the state of the art of calorimetry application to the study of biomembranes, nucleic acids, and proteins, as well as biomedical applications. I think all newcomers should take the time to read the book from its beginning to grasp how the field started and until the end to have an idea on where it is expanding to."—Watson Loh, Professor of Physical Chemistry, Institute of Chemistry, University of CampinasTable of ContentsIntroduction: Historical and Methodological Context. Membrane Characterization and Partition to Membranes. Nucleic Acids and Proteins: Stability and Their Interactions with Ligands. Calorimetry as a Tool in Applied Fields.

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Book SynopsisAsymmetric synthesis is an integral part of synthetic organic chemistry. Some of the reactions in this book were known prior to 1980, while several new ones, particularly catalytic asymmetric reactions, have been discovered in the recent years. The impact of this new class of reactions has been impressively extensiveboth on organic and medicinal chemistry. These reactions have been accepted whole-heartedly by synthetic organic chemists in developing shorter routes for complex natural targets as well as in the manufacture of a wide range of drug intermediates.Table of ContentsIntroduction. Terms, Definitions and Concepts in Asymmetric Synthesis. Achiral and Chiral Molecules and Their Properties. Prochirality. Enantioselective and Diastereoselective Synthesis. Methods for Monitoring Enantioselective and Diastereoselective Synthesis. Methods for Inducing Asymmetry. Chiral Substrate Controlled Asymmetric Reactions: Diastereoselection in acyclic systems. Chiral auxiliary controlled asymmetric reactions—Asymmetric α-alkylations. Chiral Stoichiometric Reagent Controlled Asymmetric Synthesis: Chiral Boron Reagents. Chiral Catalyst Mediated Asymmetric Reactions: Enzymes. Chiral Organometallic Catalysed Asymmetric Reactions: Sharpless Asymmetric Epoxidations, Dihydroxylations and Aminohydroxylations. Chiral Organometallic Catalysed Asymmetric Reactions. Organocatalysts in Asymmetric Synthesis—Chiral Additive Mediated Reactions. Asymmetric Aldol Reaction. Asymmetric Diels–Alder reactions. Stereoselective Synthesis and Stereospecific Synthesis. Index.

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Book SynopsisRecently, there has been a fundamental shift in the global health and wellness industry from disease treatment to preventing chronic diseases. The use of nutraceuticals and functional foods in prevention efforts could lead to a decreased dependency on drugs. The pharmaceutical industry recognizes this shift; however, serious concerns have arisen regarding the claimed efficacy, quality, and safety of products used as medical foods.This book examines the consumer and industry mindshift, including the scientific evidence of these foods as effective adjuncts to pharmacotherapy during all stages of treatment of various diseases, thus indicating that pharmaceuticals and nutraceuticals can and should coexist. It details quality, safety, and efficacy of foods, drugs, and nutrients; marketing and product positioning; regulatory perspectives; biomarkers and metabolites; probiotics; food/drug interactions; and future industry trends. In addition, food bioactives represent diet-basedTrade ReviewPharmaceuticals to Nutraceuticals: A Shift in Disease Prevention considers the recent shift in the health and consumer industries from treating diseases and conditions to preventing them, and offers a scientific survey of the use of nutraceuticals and foods in these prevention efforts. While the pharma industry has acknowledged this change, there remain many questions about quality and product safety when it comes to medicinal foods - questions surveyed in this book, which gathers under one cover the scientific studies and research surrounding food, nutrient and drug applications, marketing, and claims. Today, human diet is believed to have a major influence on both the development and prevention of age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. Prescription-based food recommending system is getting more popular today. The underlying fact is ‘NextGen’ population today is seeking for preventive evidence based solutions and want to empower the responsible management of health. College-level students of health and nutrition as well as practicing professionals in these fields will appreciate the inclusion of many different studies and assessments of therapies and their results, and will find this global focus offers a solid contrast and assessment of food-based prevention claims. The result is an in-depth collection highly recommended for any professional or college collection.Source: Midwest BookreviewTable of ContentsIntroduction. Quality-Safety-Efficacy: 3 Mantras. Marketing & Product Positioning. Regulatory Perspective. Science Underpinning. New Journeys through Categorization. Future Trends.

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Book SynopsisObesity is considered a complex and multifactorial disease. Its treatment, therefore, must also be multimodal and tailored to meet the needs of each patient. Obesity: Evaluation and Treatment Essentials presents a wide spectrum of practical treatment protocols for obesity including exercise, pharmacology, behavior modification, and dietary factors, from the point of view of the practicing physician.The book includes information about the new pharmacotherapy available for the treatment of obesity. It also includes a chapter on medical treatment of pediatric obesity that identifies the special needs of children and outlines approaches for managing the obese child. A chapter on binge eating disorder has been added and the information on pharmacology of bariatric medicine has been updated. The book addresses various dietary interventions such as low-calorie balanced diets, low-carbohydrate diets, and very-low-carbohydrate diets while also exploring the comorbidities of obeTable of ContentsObesity: The Scope of a Growing Problem. Etiologies of Obesity. Health Hazards of Obesity. Evaluation of the Obese Patient. Dietary Treatment of the Obese Individual. The Role of Physical Activity in the Treatment of the Obese Individual. Behavioral Modification. Pharmacotherapy. Maintenance of Weight Loss. Surgical Treatment of the Obese Individual. Medical Treatment of Pediatric Obesity. Binge Eating Disorder (BED): Etiology, Assessment, Diagnosis and Treatment. Current Research and Future Hope. Appendix A: Notes on Nutrition for Obesity Medicine. Appendix B: Behavioral Modification Attachments. Appendix C: ASBP Algorithm.

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Book SynopsisWith life expectancy increasing globally, older adults around the world want to live active lifestyles with improved health and higher quality of life. Physiology of Exercise and Healthy Aging, Second Edition, examines the effects of the aging process on the major physiological systems and identifies the positive impacts of physical activity and regular exercise for older adults, including delaying specific diseases and increasing quality of life. Students will be presented with foundational concepts of physiology to understand the structural and functional changes on the major physiological systems throughout the aging process. Physiological responses to acute and chronic exercise are examined, with comprehensive coverage of studies on age-related diseases and other common issues for older adults, including cardiovascular disease, cardiorespiratory fitness, type 2 diabetes, muscle metabolism and strength, osteoporosis, neurophysiology, and arthritis, plus content new to this edition that addresses mental health, pelvic floor issues and incontinence, and sexual activity. Programming recommendations in each chapter translate exercise science into practice, examining the benefits of exercise, contraindicated exercises, and other forms of physical activity beneficial to the aging population. Exercise considerations address the training needs of older adults in three unique groups: average aging adults, frail elderly with special needs, and masters athletes, with expanded content more reflective of today''s active seniors. With an emphasis on screening and assessment, coupled with basic principles of exercise and training programs, students will learn to safely administer exercise programs that meet the needs of older adults—in any stage of aging and at various levels of physical activity—to contribute to increased health and quality of life for all. Chapter-opening quotes bring content to life with insights from scientists, fitness professionals, and other experts. Chapter objectives, new to this edition, help readers to understand and apply key concepts. Questions to Consider at the end of each chapter provide tools for reflection, while references direct students to additional reading and opportunities for further learning. An appendix offers easy access to assessments and forms, including a Three-Day Nutritional Assessment form and a Client Report form, preparing readers for professional use in their careers with older adult clients.Physiology of Exercise and Healthy Aging, Second Edition, delivers a thorough discussion of the physiological effects of aging and illustrates the power of exercise as a tool to reduce or offset the effects of aging in order to improve the quality of life enjoyed by our aging population.Table of ContentsIntroduction Physical and Cognitive Changes With Aging The Process of Aging Aging and Homeostatic Processes Aging Demographics Theories of Aging Physical Activity and Aging Programming Recommendations SummaryPart I. Physiological Systems, Age-Related Changes, and the Role of Physical ActivityChapter 1. Cardiopulmonary SystemKevin Shoemaker and Patrice Brassard Structure and Function Age-Related Changes Cardiovascular Disease and Age SummaryChapter 2. Musculoskeletal SystemKevin Milne, Matthew Krause, and Albert W. Taylor Muscle Morphology Age-Related Changes in Biochemical Properties Skeletal Muscle, Aging, and Training Age-Related Diseases Limiting Exercise Programming Recommendations SummaryChapter 3. Nervous SystemPierre M.L. Deprez Overview of the Nervous System Age-Related Diseases Interventions in Age-Related Changes in the Nervous System SummaryChapter 4. Sensory SystemsPierre M.L. Deprez Hearing Vision Touch Smell Taste Programming Recommendations SummaryPart II. Related Common Diseases and Maladies, and the Role of Physical ActivityChapter 5. Diet and Diabetes ManagementSarah O’Connor and Paul Poirier Introduction Types of Diabetes Complications Associated With Diabetes Basic Nutritional Principles in the Management of Diabetes Prevention of Diabetes Diabetes and Physical Activity Dietary Guidelines for Diabetes Beneficial Dietary Patterns for Diabetes Dietary Considerations for Diabetes During Pregnancy Diabetes Management Among Older Adults Clinical Approaches and Practical Tools SummaryChapter 6. Bone Health, Osteoporosis, and ExerciseDarien Lazowski-Fraher Bone Function and Structure Osteoporosis Nutrition for Bone Health Physical Activity for Bone Health Programming Recommendations SummaryChapter 7. Osteoarthritis, Aging, and Physical ActivityJane Thornton and Gilbert Moatshe Structure and Function of the Joints Osteoarthritis Treatment Programming Recommendations Risks and Precautions for People With OA SummaryChapter 8. Aging, the Pelvic Floor, Incontinence, and ExerciseLinda McLean and Carolyn Vandyken Introduction Continence Control and Types of Urinary Incontinence Anatomy and Function of the Pelvic Floor Evidence for Age-Related Changes in the Pelvic Floor as They Relate to Continence Function Evidence-Based Strategies for the Maintenance of a Healthy Pelvic Floor With Aging Pelvic Floor Muscle Training Exercise Prescription A Final Word SummaryChapter 9. Mental Health, Aging, and Physical ActivityAndrea Lazosky Prevalence of Mental Health Issues With Aging Pathophysiology of Depression With Aging Psychosocial Theories of Aging The Role of Physical Activity on Mental Health With Aging Forms of Physical Activity SummaryChapter 10. Sex, Aging, and Physical ActivityLee Smith and Igor Grabovac Prevalence of Sexual Activity in Aging Biopsychosocial Model of Changes Related to Sexuality in Later Life Prevalence of Sexual Dysfunction in Older Adults Physical and Mental Health Benefits of a Frequent and Trouble-Free Sex Life in Later Life The Role of Physical Activity on Sexuality in Older Adults SummaryPart III. Physiologic Adaptability to Training and Physical ActivityChapter 11. Balance Control and Prevention of Falls in Older AdultsGrant Handrigan The Biomechanics of Balance Control Fall Risk Factors Fall Risk Prevention SummaryChapter 12. A Functional Approach to ExerciseDenise M. Connelly Principles of Exercise Exercise and Cognitive Impairment Exercise Prescription Exercise Programming Programming Recommendations SummaryChapter 13. Training for Aerobic and Anaerobic FitnessEdward Todd Taylor and Tom Overend Brief Review of Exercise Physiology Benefits of Aerobic and Anaerobic Fitness Research on the Positive Effects of Aerobic Exercise and Training Research on the Positive Effects of Anaerobic Exercise and Training Programming Recommendations Recommendations for “Frail” Elderly Aerobic and Anaerobic Exercise Integration SummaryChapter 14. Training for Muscle Performance for Older AdultsMichelle Cardoso and Chantale R. Brun Muscle Performance and Aging Muscle Mass, Strength, and Function SummaryChapter 15. Exercise Adherence and Safety MeasuresJames Sawchuk and Albert W. Taylor Exercise Adherence Safety Programming Recommendations SummaryChapter 16. Clean Sport for Masters AthletesTaryn-Lise Taylor and Sean Mindra Masters Athletes Hormones Anabolic Steroids Analgesics and Anti-Inflammatories Hypertension Medications Erythropoietin Dietary Supplementation and Ergogenic Aid Summary Appendix A: Web Resources Appendix B: Forms

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Book SynopsisChinese Dates: A Traditional Functional Food delivers unique information on Chinese dates (jujubes) as typical ethical foods and traditional health-promoting foods. It conveys a better understanding of Asian food cultures and provides historical information in regard to traditional functional foods and their dietary applications. It discusses the health-promoting benefits of a wide variety of jujube fruits and covers different jujube products, such as jujube fruit juice and cakes. It also looks into the many kinds of jujube fruit-based medicated diets, describes innovative new processing technologies and novel jujube products, and examines ethnomedicinal uses, pharmacological activity, and phytochemical constitutes of jujubes.The book's four sections and nineteen chapters provide information on Chinese date's origin, distribution, varieties, chemical composition, biochemical properties, traditional products and technology, innovative processing technology, foTable of ContentsORIGINAL, DISTRIBUTION, AND GROWING CONDITION OF CHINESE DATES (JUJUBES). CHEMICAL AND BIOCHEMICAL PROPERTIES AND HEALTH BENEFITS OF CHINESE DATES (JUJUBES). CHINESE DATE (JUJUBE) PRODUCTS AND POSTHARVEST TECHNOLOGY. CHINESE DATE (JUJUBE) INDUSTRY IN DIFFERENT COUNTRIES.

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Book SynopsisThe scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.Table of ContentsCilia in the Brain – Development and Disease. Cilia in Lung Development and Disease. The Role of Cilia in Heart Development and Disease. Cilia in Kidney Development and Disease. The Role of Cilia in Pancreatic Development and Disease. The Role of Cilia in Skeletal Development and Disease. The Role of Cilia in Development and Disease of the Eye. The Role of Cilia in the Auditory System.

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Book SynopsisOur skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.Table of ContentsOverview. Human Skin Natural Aging and Sun-induced Premature Aging. Molecular Mechanisms of Human Skin Aging. Age-Related Skin Diseases (Skin Cancer and Wound Healing in Elderly). Prevention of Human Skin Aging and Age-Related Skin Diseases. Human Skin Rejuvenation.

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Book SynopsisCobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery. This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifacetTable of ContentsMilestones in the Discovery of Pernicious Anemia and Its Treatment. Nutritional and Biochemical Aspects of Cobalamin throughout Life. Intracellular Processing and Utilization of Cobalamins. Inherited Defects of Cobalamin Metabolism. Conditions and Diseases that Cause Vitamin B12 Deficiency: Form Metabolism to Diseases. Vitamin B12 Deficiency in Developing and Newly Industrialising Countries. Vitamin B12 in Neurology and Aging. The Role of Cobalamin in the Central and Peripheral Nervous Systems: Mechanistic Insights. Laboratory Markers and Diagnosis of Cobalamin Deficiency. Cobalamin during Pregnancy and Lactation. Vitamin B12 after Birth and during Early Life. Cobalamin – Folate Interactions. Extreme Vitamin B12 Concentrations in Clinical Practice in the Absence of Symptoms or B12 Treatment. Vitamin B12 and Drug Development.

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Book SynopsisPolymers have emerged as one of the most innovative classes of materials in modern materials science, leading to new applications in medicine and pharmacy. This book offers a convincing and understandable approach to polymer biomaterial devices being used in various areas related to biomedical and pharmaceutical fields. The polymer materials finding application as biomaterials are discussed and described in detail pertaining to the areas of artificial implants, orthopedics, ocular devices, dental implants, drug delivery systems, burns and wounds. Table of ContentsIntroduction. Polymers in Dental Devices. Polymers in Orthopedic Devices. Polymers in Drug Delivery Systems. Polymers in Wound Dressing Materials. Polymers in Tissue Engineering. Polymers in Ocular Devices. Polymers in Cardiovascular Systems. Present Market of Available Polymer Biomedical Devices. Present Challenges and Future Prospects.

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Book SynopsisMiniaturization in the fields of chemistry and molecular biology has resulted in the lab-on-a-chip. Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of organ-on-a-chip systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor designTable of ContentsIntroduction. Microfabrication and 3D Bioprinting. 3D Cell Culture/Tissue Spheroids. Biosensors and Microelectronics. Microfluidics. Big Data/Predictive Analysis. Lab-on-a-Chip. Lung-on-a-Chip. Liver-on-a-Chip. Heart-on-a-Chip. Skin-on-a-Chip. Kidney-on-a-Chip. Body-on-a-Chip. Liver Cancer-on-a-Chip. Lung Cancer-on-a-Chip. Breast Cancer-on-a-Chip. Cancer Metastasis-on-a-Chip. Cancer Microenvironment-on-a-Chip. Disease Modeling. Toxicology Testing. Detection of Bioweapon Pathogens. Personalized Medicine.

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Book SynopsisApplied Molecular Biotechnology: The Next Generation of Genetic Engineering explains state-of-the-art advances in the rapidly developing area of molecular biotechnology, the technology of the new millennium. Comprised of chapters authored by leading experts in their respective fields, this authoritative reference text: Highlights the latest omics-based tools and approaches used in modern biotechnology Explains how various molecular biology technologies can be used to develop transgenic plants and how those plants can meet growing food and plant-derived product demands Discusses chloroplast gene expression systems, mitochondrial omics, plant functional genomics, and whole-genome resequencing for crop improvement Explores plantmicrobe and plantinsect interactions affecting plant protection and productivity Covers animal models, pharmacogenomics, human tissue banking, and the molecular diagnosis of diseases such as cervicalTrade Review"... timely and very much needed. … a comprehensive … [book] covering all important aspects of the technology."—From the Foreword by Dr. Kauser Abdulla Malik, HI, SI, TI, Distinguished National Professor, Dean for Postgraduate Studies, Forman Christian College (A Chartered University), Lahore, Pakistan "This book is certainly a very valuable guide for any safety manager intending to build and maintain an effective safety activity. The focus on human factors is on the most relevant aspects as much as the need to define the most valuable ways to perform a retrospective analysis of occurrences. The implementation of a Safety Management System is the essential instrument on which safety processes and company operations are based. The correct approach to dealing with human factors and in particular to analyzing the contribution pf human errors to incident causation is a crucial pillar, but not the only one, on which the entire foundation of organizational safety is based. This book offers a valuable support in ensuring this is achieved." —Cogn Tech Work, 2016 "... timely and very much needed. … a comprehensive … [book] covering all important aspects of the technology."—From the Foreword by Dr. Kauser Abdulla Malik, HI, SI, TI, Distinguished National Professor, Dean for Postgraduate Studies, Forman Christian College (A Chartered University), Lahore, Pakistan "This book is certainly a very valuable guide for any safety manager intending to build and maintain an effective safety activity. The focus on human factors is on the most relevant aspects as much as the need to define the most valuable ways to perform a retrospective analysis of occurrences. The implementation of a Safety Management System is the essential instrument on which safety processes and company operations are based. The correct approach to dealing with human factors and in particular to analyzing the contribution pf human errors to incident causation is a crucial pillar, but not the only one, on which the entire foundation of organizational safety is based. This book offers a valuable support in ensuring this is achieved." —Cogn Tech Work, 2016 Table of ContentsEmerging Tools and Approaches to Biotechnology in the Omics Era. Plant Molecular Biology: Tools to Develop Transgenics. Plant Molecular Biotechnology: Applications of Transgenics. The Chloroplast Gene-Expression System. Molecular Biology of Mitochondria: Genome, Transcriptome, and Proteome. Plant Functional Genomics: Approaches and Applications. Whole-Genome Resequencing: Current Status and Future Prospects in Genomics-Assisted Crop Improvement. Molecular Biotechnology of Plant–Microbe–Insect Interactions. Biotechnology for Improved Crop Productivity and Quality. Overview of Methods to Unveil the Epigenetic Code. Animal Models and Biomedical Research. Variations in Our Genome: From Disease to Individualized Cure. Molecular Biotechnology for Diagnostics. Techniques for Cervical Cancer Screening and Diagnosis. Type 2 Diabetes Mellitus, Obesity, and Adipose Tissue Biology. Human Tissue Banking and Its Role in Biomedical Research. Microbial Biotechnology. Molecular Biology of Viruses: Disease Perspective. Viral Biotechnology: Production Perspective. Cell-Free Biosystems. Magnetic Nanoparticles with Multifunctional Water-Soluble Polymers for Bioapplications. Industrial Biotechnology: Its Applications in Food and Chemical Industries. Environmental Biotechnology: Approaches for Ecosystem Conservation. Marine Biotechnology: Focus on Anticancer Drugs. Engineering Genomes for Biofuels.

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Book SynopsisGiven its ubiquity, plugin-free deployment, and ease of development, the adoption of WebGL is on the rise. Skilled WebGL developers provide organizations with the ability to develop and implement efficient and robust solutionsâcreating a growing demand for skilled WebGL developers.WebGL Insights shares experience-backed lessons learned by the WebGL community. It presents proven techniques that will be helpful to both intermediate and advanced WebGL developers.By focusing on current and emerging techniques, the book demonstrates the breadth and depth of WebGL. Readers will gain practical skills to solve problems related to performance, engine design, shader pipelines, rendering, mobile devices, testing, and more.Throughout the book, experienced WebGL engine and application developers, GPU vendors, browser developers, researchers, and educators share their unique expertise based on their real-world experiences. This includes hardware vendors sharing pTrade ReviewThis book and the accompanying website represent the epitome of the web’s sharing culture: a curated collection of leading-edge techniques and insights, with online source code and live demonstrations. In this book, engine authors present their strategies for achieving high-performance, good scalability, and leading-edge visuals. Educators share their experience in moving real-time computer graphics courses to the web and WebGL. Application developers and toolchain authors share their experiences both building large, new JavaScript code bases and bringing existing C++ code bases to the web. Graphics researchers show how to implement leading-edge rendering techniques in WebGL, allowing these techniques to be deployed seamlessly to hundreds of millions of devices and billions of people. Visualization researchers demonstrate how to render huge data sets with high performance and high impact. Interaction researchers provide insights into effective navigation and interaction paradigms for 3D applications. Finally, browser and GPU implementers give a look under the hood of WebGL implementations to help developers tune their code for best performance on a range of devices.This book contains a wealth of information and will be a treasured reference for years to come. —Ken Russell, Khronos WebGL Working Group Chair, Software Engineer, Google Chrome GPU TeamTable of ContentsWebGL Implementations. Moving to WebGL. Mobile. Engine Design. Rendering. Visualization. Interaction.

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Book SynopsisThe role of green coffee bean (GCB) in human health is of emerging interest to the nutraceutical field, especially given its role in improving metabolic syndrome, including weight management, hypertension, diabetes, and neuroprotection. GCB extract contains a novel antioxidant known as chlorogenic acid (also caffeoylquinic acid), which has been shown to positively affect blood pressure, brain health, diabetes, and weight management. This book provides information on the diverse health benefits of green coffee bean extract, molecular mechanisms and signaling pathways, safety of GCB, dosage, and recommended usage. It focuses on the chemistry, biochemistry, pharmacology, and safety of GCB extract.GCB extract has brought a remarkable revolution in the nutraceutical marketplace. However, some controversies have been demonstrated recently. This book presents the state-of-the-art research studies from eminent scientists around the world on the potential and diversified health beTable of ContentsIntroduction. An Overview on Green Coffee Bean. Chlorogenic Acid: An Integral Constituent of Green Coffee Bean. Diverse Health Benefits of Green Coffee Bean Extract. Molecular Mechanisms and Signaling Pathway. Safety of Green Coffee Bean. Dosage & Recommended Use.

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Book SynopsisThis book provides a comprehensive overview of music data analysis, from introductory material to advanced concepts. It covers various applications including transcription and segmentation as well as chord and harmony, instrument and tempo recognition. It also discusses the implementation aspects of music data analysis such as architecture, user interface and hardware. It is ideal for use in university classes with an interest in music data analysis. It also could be used in computer science and statistics as well as musicology.Trade Review " . . . what makes this book unique is that it covers a much broader range of topics. Not only does it present a concrete tutorial on signal processing and music information retrieval . . . , but it also talks about interesting topics such as emotions, automatic composition, hardware, and others, so readers are sure to find novel information . . . In summary, MusicDataAnalysis is well thought-out and well written. It chooses to emphasize a breadth of topics rather than specialize in specific ones. This book nicely accomplishes its goal of serving as an introductory textbook for music research. It is also a very useful reference and valuable resource for individuals seeking new directions in the field." ~Yupeng Gu, Journal of the American Statistical Association". . . the book is impressive in its structure, comprehensiveness, clarity and accuracy. . . This text has staked out a specialised interdisciplinary niche, but as a self-contained guide to computational methods for music, I think it unlikely to be surpassed in the near future." ~David Bulger, Australian & New Zealand Journal of Statistics"Theoretical and practical exercises based on R and MATLAB are provided in the book’s web site, as well as example data sets. The book is very clearly written, and the style is fairly uniform despite the large number of authors. In sum, a very useful and enjoyable book." ~Ricardo Maronna, Stat Papers" . . . what makes this book unique is that it covers a much broader range of topics. Not only does it present a concrete tutorial on signal processing and music information retrieval . . . , but it also talks about interesting topics such as emotions, automatic composition, hardware, and others, so readers are sure to find novel information . . . In summary, MusicDataAnalysis is well thought-out and well written. It chooses to emphasize a breadth of topics rather than specialize in specific ones. This book nicely accomplishes its goal of serving as an introductory textbook for music research. It is also a very useful reference and valuable resource for individuals seeking new directions in the field." ~Yupeng Gu, Journal of the American Statistical Association". . . the book is impressive in its structure, comprehensiveness, clarity and accuracy. . . This text has staked out a specialised interdisciplinary niche, but as a self-contained guide to computational methods for music, I think it unlikely to be surpassed in the near future." ~David Bulger, Australian & New Zealand Journal of Statistics"Theoretical and practical exercises based on R and MATLAB are provided in the book’s web site, as well as example data sets. The book is very clearly written, and the style is fairly uniform despite the large number of authors. In sum, a very useful and enjoyable book." ~Ricardo Maronna, Stat PapersTable of ContentsMUSIC AND AUDIO. Introduction. The Musical Signal - Physically and Psychologically. Musical Structures and Their Perception. Digital Signal Processing. Digital Representation of Music. Signal-level Features. METHODS. Foundations of Statistics. Optimization. Unsupervised Classification. Supervised Classification. Evaluation. Feature Processing. Feature Selection. APPLICATIONS. Transcription. Segmentation. Instrument Recognition. Chord and Harmony Recognition. Tempo Recognition. Emotions. Structuring Of Music Collections. Music Recommendation. Automatic Composition. IMPLEMENTATION. Architecture. User Interaction. Hardware.

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Book SynopsisOriginally published in 1982 by Pearson/Prentice-Hall, the Forensic Science Handbook, Third Edition has been fully updated and revised to include the latest developments in scientific testing, analysis, and interpretation of forensic evidence. World-renowned forensic scientist, author, and educator Dr. Richard Saferstein once again brings together a contributor list that is a veritable Who's Who of the top forensic scientists in the field. This Third Edition, he is joined by co-editor Dr. Adam Hall, a forensic scientist and Assistant Professor within the Biomedical Forensic Sciences Program at Boston University School of Medicine. This two-volume series focuses on the legal, evidentiary, biological, and chemical aspects of forensic science practice.The topics covered in this new edition of Volume I include a broad range of subjects including: Legal aspects of forensic science Analytical instrumentation to include: microspectrophotometry, infrared Spectroscopy, gTable of Contents1. Legal Aspects of Forensic Science[Gil I. Sapir]2. Forensic Paint Examination[Diana Wright, Daniel Kirby, and John Thornton]3. The Forensic Identification and Association of Human Hair[Richard E. Bisbing]4. A Guide to the Analysis of Forensic Household Dust Specimens and Their Statistical Significance [Nicholas Petraco and Nicholas D. K. Petraco]5. Fundamentals of Visible Microspectrophotometry in Forensic Science[Michael B. Eyring]6. Infrared Spectroscopy in the Forensic Sciences[Edward M. Suzuki]7. Forensic Characterization and Comparisons of Inks[Tatiana Trejos and Jose Almirall]8. Forensic Gas Chromatography[Thomas A. Brettell and David T. Stafford]9. Forensic Applications of High Performance Liquid Chromatography and Capillary Electrophoresis[David Northrup]10. Forensic Mass Spectrometry[Adam B. Hall and Richard Saferstein]11. Analysis of Body Fluids in Sexual Assault Cases[Edwin Jones]12. The Application of Capillary Electrophoresis in Forensic DNA Analysis[Bruce McCord]

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Book SynopsisStart Analyzing a Wide Range of Problems Since the publication of the bestselling, highly recommended first edition, R has considerably expanded both in popularity and in the number of packages available. Extending the Linear Model with R: Generalized Linear, Mixed Effects and Nonparametric Regression Models, Second Edition takes advantage of the greater functionality now available in R and substantially revises and adds several topics.New to the Second Edition Expanded coverage of binary and binomial responses, including proportion responses, quasibinomial and beta regression, and applied considerations regarding these models New sections on Poisson models with dispersion, zero inflated count models, linear discriminant analysis, and sandwich and robust estimation for generalized linear models (GLMs) Revised chapters on random effects and repeated measures that reflect changes in the lme4 package and showTrade Review"What I liked most with this book was the comprehensive treatment of the practical application of GLMs, covering most outcomes an applied statistician will encounter, and at the same time presenting just enough of the necessary theoretical basis for the discussed methods. Combined with the thorough discussion of the R output, the text will serve as a useful guide for the reader when applying the methods to his or her own data set."—Psychometrika, 2018 "The second edition of book ‘Extending the linear model with R’ by Julian Faraway is an easily readable and relatively thorough (without being theory heavy) sequel of the earlier ‘Linear Models with R’ by the same author. The book itself is written in a self-paced tutorial style in easily digestible chunks integrating descriptions of underlying methodology, with data analysis and R code. The organization of the book is well thought through. The flow of the book is problem driven rather than driven by the underlying statistical theory . . . the second edition is more polished in terms of the figures used, R code and output display and a crisper typesetting of equations."—John T. Ormerod, University of Sydney Praise for the First Edition:"… well-written and the discussions are easy to follow … very useful as a reference book for applied statisticians and would also serve well as a textbook for students graduating in statistics."—Computational Statistics, April 2009, Vol. 24 "The text is well organized and carefully written … provides an overview of many modern statistical methodologies and their applications to real data using software. This makes it a useful text for practitioners and graduate students alike."—Journal of the American Statistical Association, December 2007, Vol. 102, No. 480 "I enjoyed this text as much as [Faraway’s Linear Models with R]. The book is recommended as a textbook for a computational statistical and data mining course including GLMs and non-parametric regression, and will also be of great value to the applied statistician whose statistical programming environment of choice is R."—Journal of Applied Statistics, July 2007, Vol. 34, No. 5 "This is a very pleasant book to read. It clearly demonstrates the different methods available and in which situations each one applies. It covers almost all of the standard topics beyond linear models that a graduate student in statistics should know. It also includes discussion of topics such as model diagnostics, rarely addressed in books of this type. The presentation incorporates an abundance of well-chosen examples … this book is highly recommended …"—Biometrics, December 2006 "It has been a great pleasure to review this book, which delivers both a readily accessible and reader-friendly account of a wide range of statistical models in the context of R software. Since the publication of the very well received first edition of the book, R has considerably expanded both in popularity and in the number of packages available. The second editionof the book takes advantage of the greater functionality available now in R, and substantially revises and adds several new topics."—Andrzej Galecki, The International Biometric Society Table of ContentsIntroduction. Binary Response. Binomial and Proportion Responses. Variations on Logistic Regression. Count Regression. Contingency Tables. Multinomial Data. Generalized Linear Models. Other GLMS. Random Effects. Repeated Measures and Longitudinal Data. Bayesian Mixed Effect Models. Mixed Effect Models for Nonnormal Responses. Nonparametric Regression. Additive Models. Trees. Neural Networks. Appendices. Bibliography. Index.

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Book SynopsisCarbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications. This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.Table of ContentsChapter 1. Introduction Nomenclature, Structure, and Stability Generation of Carbocations The Non-Classical Ion Controversy Electrophilic Addition to Alkenes Electrophilic Aromatic Substitution Elimination reactions Rearrangement Reactions of Carbocations References Chapter 2. Nucleophilic Aliphatic Substitution – SN1 Introduction -Activated Alcohols—Brønsted Acids -Activated Alcohols—Lewis Acids Alkylation of Aldehydes and Ketones Glycosylation Friedel–Crafts Alkylation and Acylation Electrophilic Fluorination Using Fluoronium Ion Miscellaneous SN1-related Reactions References Chapter 3. Nucleophilic Aliphatic Substitution – SN2 Construction of Quaternary Stereogenic Centers Sulfur Chemistry Organometallic Chemistry Macrocyclization Glycosylation Nucleoside Analogues N-Alkylation Cyclotetraphosphazenes Conformationally Locked Tetrahydropyran Ring The Ionic Liquid Effect Silver Chemistry References Chapter 4. Electrophilic Addition to Alkenes Introduction Cyclopropanation Hydroboration/Oxidation The Pauson–Khand Reaction Prins Reaction Schmidt Reaction Halogenation Oxymercuration/Reduction Epoxidation Gold-Catalyzed Alkyne Hydration Conclusion References Chapter 5. Electrophilic Aromatic Substitution Introduction Nitration Halogenation Friedel–Crafts Alkylation Friedel–Crafts Acylation Applications of Friedel–Crafts Reaction on Total Synthesis Miscellaneous Electrophilic Aromatic Substitution Reactions References Chapter 6. Fragmentation and Rearrangement Reactions Claisen Rearrangements Cope Rearrangements Cope Rearrangements Aldehyde (or Ketone) Formation Rearrangements Carboxylic Acid Formation Rearrangements Alcohol Formation Rearrangements Amine Formation Rearrangement Amides Hydrocarbon Rearrangements Oxacyclic, Carbocyclic, Oxazoles, Tetrahydrapuran and Tetrahydropuran Formation Rearrangements Rearrangements resulting in less common functional groups Fragmentations References

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Book SynopsisThis robust, dynamic, and international field has grown to include interdisciplinary research, continually improving methodology, and globalization of training. Reflecting the diverse nature of the science from experts who have shaped it, Forensic Anthropology: A Comprehensive Introduction Second Edition builds off of the success of the first edition and incorporates standard practices in addition to cutting-edge approaches in a user-friendly format, making it an ideal introductory-level text.Table of Contents AcknowledgementsAbout the EditorsAbout the ContributorsPrefacePart 1: Forensic Anthropology and the Crime SceneChapter One: Forensic Anthropology in the United States: Past and PresentMariaTeresa A. Tersigni-Tarrant and Natalie R. LangleyChapter Two: Skeletal Remains as EvidenceMarin A. Pilloud and MariaTeresa A. Tersigni-TarrantChapter Three: Forensic Archaeology: Survey Methods, Scene Documentation, Excavation, and Recovery MethodsDenise ToChapter Four: Forensic TaphonomyJames Pokines and MariaTeresa A. Tersigni-TarrantPart 2: The Skeleton and Skeletal DocumentationChapter Five: Human OsteologyMariaTeresa A. Tersigni-Tarrant and Natalie R. LangleyChapter Six: Human Odontology and the Dentition in Forensic AnthropologyDebra Prince Zinni and Kate M. CrowleyChapter Seven: Skeletal Examination and DocumentationLee Meadows JantzPart 3: Skeletal Individuation and AnalysesChapter Eight: Sex Estimation of Unknown Human RemainsGregory E. BergChapter Nine: Ancestry Methods: The Importance, The History And The PracticeM. Katherine Spradley and Katy E. WeisenseeChapter Ten: Age Estimation MethodsNatalie R. Langley, Alice F. Gooding, MariaTeresa A. Tersigni-TarrantChapter Eleven: Stature EstimationNatalie R. LangleyChapter Twelve: Pathological Conditions as Individuating Traits in a Forensic ContextDavid Hunt and Kerriann MardenChapter Thirteen: Analysis of Skeletal TraumaNatalie R. LangleyChapter Fourteen: Introduction to Fordisc 3 and Human Variation – StatisticsRichard L. Jantz and Stephen D. OusleyPart 4: Human Identification and Advanced Forensic Anthropology ApplicationsChapter Fifteen: Time Since Death Estimation and Bone Weathering: The Postmortem IntervalRebecca J. Wilson-Taylor and Angela M. DautartasChapter Sixteen: Methods of Personal IdentificationAngi M. Christensen and Bruce E. AndersonChapter Seventeen: Mass Fatalities, Mass Graves and the Forensic Investigation of International CrimesPierre Guyomarc’h and Derek CongramChapter Eighteen: Advanced Scene Topics: Fire and ComminglingJoanne Bennett Devlin and Nicholas P. HerrmannAppendix A: Application of Dentition In Forensic AnthropologyDebra Prince Zinni and Kate M. CrowleyAppendix B: Age Estimation in Modern Forensic AnthropologyBridget F. B. Algee-HewittGlossaryIndex

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Book SynopsisGap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.Table of ContentsGap junction channels. Bioinformatics analysis of connexin genes. Structural approaches on gap junction channels. Fluorescent label of connexins. Functional study of gap junction channel gating. Quantitative measurement of dye transfer. Permeability. Pharmacology of gap junction channels. Gap junction mimetic piptides. Gap junction hemichannels. Dye uptake and ATP release. Functional study of hemichannel current. Connexin purification and reconstitution in lipid bilayers. Hemichannel function in the ovary. Pannexin channels. Functional study pannexin channels. Pannexin channels in vasculature. Pharmacology of pannexin channels. Dye uptake and ATP release.

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Book SynopsisThis book provides a wide spectrum of readers with comprehensive but easily understandable protocols for the assessment and training of wheelchair skills. The Wheelchair Research Team at Dalhousie University and the Capital District Health Authority in Halifax (lead by the author) have focused on wheelchair safety and performance for three decades, as exemplified through the Wheelchair Skills Program. This is considered the top such program in the world. This new book is largely based on this program which has been accessed and utilized by over 75,000 people in 177 countries since 2007. Table of ContentsIntroduction to the WSTP, General Background on Motor Skills Learning, Specific Issues fo Importance for Motor Skills Learning, Lesson Plans, Skill Groups. Individual Skills, Games

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Book SynopsisApart from malaria, schistosomiasis is the most prevalent parasitic infection in the world. It affects more than 200 million people in 76 tropical and subtropical countries, causing great suffering and resulting in thousands of deaths. Written by world authorities, this book examines many aspects of the biology, pathology, and control of the schistosoma parasite. Ranging in topic from infection in Pharaonic Egypt, through DNA relationships and biological systems, to advances in development of vaccines against the parasite, this book is a comprehensive text written for researchers and medical professionals alike.Table of ContentsOrigins and Evolutionary Radiation of Schistosoma. Schistosomiasis: Paleopathological Perspectives and Historical Notes. Life Cycles of Schistosomiasis. Schistosoma Intermediate Host Snails. Schistosoma Egg. Miracidium of Schistosoma. Schistosoma Sporocysts. Cercaria of Schistosoma. Schistosomula. Tegument and External Features of Schistosoma. Alimentary Tract of Schistosoma. Nervous and Sensory System of Schistosoma. Reproductive System of Schistosoma. Spermatozoa, Spermatogenesis and Fertilization in Schistosoma. Ova and Oogenesis in Schistosoma. Excretory System of Schistosomes. Acute Schistosomiasis. Chronic Schistosomiasis. Neuroschistosomiasis: Pathogenesis and Clinical Manifestations. Subtle Morbidity in Schistosomiasis. Diagnostic Tests for Schistosomiasis. Control of Schistosomiasis. Chemotherapy against Schistosomiasis. Schistosomiasis Vaccine Development: the Missing Link. Geospatial Surveillance and Response Systems for Schistosomiasis. Future Directions: The Road to Elimination.

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Book SynopsisThis book contains a comprehensive overview of all current uses of robots in rehabilitation. The underlying principles in each application are provided. This is followed by a critical review of the technology available, of the utilization protocols, and of user studies, outcomes, and clinical evidence, if existing. Ethical and social implications of robot use are also discussed. The reader will have an in depth view of rehabilitation robots, from principles to practice.Table of ContentsFundamentals of Robot Application, Human Robot Interaction, Robotic Systems to Support Manipulation, Robotic Prosthesis, Robotic Systems to Support Mobility, Robots for Rehabilitation Therapy, Exoskeletons, Robotic Systems to Promote Cognitive Development, Social Robotics-Children with ASD, Social Robotics - Elderly, Personal Assistant Robots, Ethical adn Social Implications.

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Book SynopsisDNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology melds two tales of DNA. One is a look at the first 35 years of DNA nanotechnology to better appreciate what lies ahead in this emerging field. The other story looks back 4 billion years to the possible origins of DNA which are shrouded in mystery. The book is divided into three parts comprised of 15 chapters and two Brief Interludes.Part I includes subjects underpinning the book such as a primer on DNA, the broader discipline of nanoscience, and experimental tools used by the principals in the narrative. Part II examines the field of structural DNA nanotechnology, founded by biochemist/crystallographer Nadrian Seeman, that uses DNA as a construction material for nanoscale structures and devices, rather than as a genetic material. Part III looks at the work of physicists Noel Clark and Tommaso Bellini who found that short DNA (nanoDNA) forms liquid crystals that act as a structural gatTrade Review‘DNA Nanoscience takes us on a journey into the future, where sub-microscopic gadgets built from DNA may be used to detect specific molecules one-at-a-time or to deliver therapeutic drugs specifically to cancer cells. Looking in the other direction, the journey takes us back 4 billion years to a time when the self-organization of DNA into liquid crystals may have facilitated the reproduction of what would become our genetic material, arguably the key step in the origin of life.DNA Nanoscience is scholarly and full of technical figures. But the science is accompanied by clear explanations that make it accessible to college student and science-savvy citizens. It is a pleasure to find a book that is so true to the science while being so enjoyable to read.’– Thomas R. CechDistinguished Professor, University of Colorado-Boulder; Director, BioFrontiers Institute; Nobel Laureate (Chemistry 1989).‘Douglas’ DNA Nanoscience is something of a miracle.’– Stuart KauffmanEmeritus Professor Biochemistry and Biophysics, University of Pennsylvania; Affiliate Professor, The Institute for Systems Biology, Seattle; Author of At Home in the Universe.‘This book changed my life. Every seven years, as my sabbatical approaches, I search about for a new direction to focus my research and Ken Douglas’ book, DNA Nanoscience, appeared just in time.’– Seth FradenProfessor of Physics; Director, The Bioinspired Soft Materials Center, Brandeis University.‘Instructive like a textbook and exciting like a novel! For everybody interested in modern natural sciences, this book is a must to read.’– Andreas HerrmannProfessor of Polymer Chemistry and Bioengineering; Chair of the Board, The Zernike Institute for Advanced Materials; University of Groningen, The Netherlands.‘To sum up, this is both a lively and profound book, the reading of which I strongly recommend.’– Jacques ProstDirector Emeritus of CNRS (Le Centre national de la recherche scientifique) at Institut Curie, Paris; Distinguished Professor, National University of Singapore.‘This book tells a fascinating new story about DNA. The subject matter also stretches as needed into biology to teach basic ideas about cell membranes and metabolism. It provides a wonderful taste of DNA nanoscience at the research frontier.’– Arjun G. YodhJames M. Skinner Professor of Science, Endowed Chair; Director, PENN Laboratory for Research on the Structure of Matter, University of Pennsylvania.‘The only way that the general public will continue to trust the proclamation of the scientific establishment is through books like this one – where the foibles and fears and eccentricities of the scientists are shown to be the same as those of the artist, musician and businessman. Scientists are just artists who want to work with mother nature, without the freedom to make up new worlds as we go along. The real world is magical enough for them.’– Joseph A. Zasadzinski3M Harry Heltzer Chair in Multidisciplinary Science and Technology; Chemical Engineering and Materials Science, University of Minnesota.'The book’s eclectic and elaborate vision, looking back to the ancient past and forward to the equally unknowable future sets Douglas’ DNA Nanoscience apart from other attempts to present DNA nanoscience.... Written in beautiful prose and richly illustrated with over 200 full-color figures ... it also serves as a bird’s-eye survey for a more general readership, viz., for those in the public who are curious and enjoy thinking. These citizens are aware of DNA nanoscience snippets making it into the daily news but would like to acquire a deeper, more meaningful and thorough understanding of what the fuss is all about.Douglas’ book DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology covers an astoundingly broad ground.... By writing this book on the emerging field of DNA nanoscience Kenneth Douglas has thus done a double service—to science as well as to its public image. I believe that the reception of the book will do justice to the meticulous research and artistry of this tome.'– Rudolf Podgornik (Jožef Stefan Institute)Journal of Biological Physics (August 2016), DOI: 10.1007/s10867-016-9425-4.‘DNA Nanoscience takes us on a journey into the future, where sub-microscopic gadgets built from DNA may be used to detect specific molecules one-at-a-time or to deliver therapeutic drugs specifically to cancer cells. Looking in the other direction, the journey takes us back 4 billion years to a time when the self-organization of DNA into liquid crystals may have facilitated the reproduction of what would become our genetic material, arguably the key step in the origin of life.DNA Nanoscience is scholarly and full of technical figures. But the science is accompanied by clear explanations that make it accessible to college student and science-savvy citizens. It is a pleasure to find a book that is so true to the science while being so enjoyable to read.’– Thomas R. CechDistinguished Professor, University of Colorado-Boulder; Director, BioFrontiers Institute; Nobel Laureate (Chemistry 1989).‘Douglas’ DNA Nanoscience is something of a miracle.’– Stuart KauffmanEmeritus Professor Biochemistry and Biophysics, University of Pennsylvania; Affiliate Professor, The Institute for Systems Biology, Seattle; Author of At Home in the Universe.‘This book changed my life. Every seven years, as my sabbatical approaches, I search about for a new direction to focus my research and Ken Douglas’ book, DNA Nanoscience, appeared just in time.’– Seth FradenProfessor of Physics; Director, The Bioinspired Soft Materials Center, Brandeis University.‘Instructive like a textbook and exciting like a novel! For everybody interested in modern natural sciences, this book is a must to read.’– Andreas HerrmannProfessor of Polymer Chemistry and Bioengineering; Chair of the Board, The Zernike Institute for Advanced Materials; University of Groningen, The Netherlands.‘To sum up, this is both a lively and profound book, the reading of which I strongly recommend.’– Jacques ProstDirector Emeritus of CNRS (Le Centre national de la recherche scientifique) at Institut Curie, Paris; Distinguished Professor, National University of Singapore.‘This book tells a fascinating new story about DNA. The subject matter also stretches as needed into biology to teach basic ideas about cell membranes and metabolism. It provides a wonderful taste of DNA nanoscience at the research frontier.’– Arjun G. YodhJames M. Skinner Professor of Science, Endowed Chair; Director, PENN Laboratory for Research on the Structure of Matter, University of Pennsylvania.‘The only way that the general public will continue to trust the proclamation of the scientific establishment is through books like this one – where the foibles and fears and eccentricities of the scientists are shown to be the same as those of the artist, musician and businessman. Scientists are just artists who want to work with mother nature, without the freedom to make up new worlds as we go along. The real world is magical enough for them.’Joseph A. Zasadzinski3M Harry Heltzer Chair in Multidisciplinary Science and Technology; Chemical Engineering and Materials Science, University of Minnesota.'The book’s eclectic and elaborate vision, looking back to the ancient past and forward to the equally unknowable future sets Douglas’ DNA Nanoscience apart from other attempts to present DNA nanoscience.... Written in beautiful prose and richly illustrated with over 200 full-color figures ... it also serves as a bird’s-eye survey for a more general readership, viz., for those in the public who are curious and enjoy thinking. These citizens are aware of DNA nanoscience snippets making it into the daily news but would like to acquire a deeper, more meaningful and thorough understanding of what the fuss is all about.Douglas’ book DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology covers an astoundingly broad ground.... By writing this book on the emerging field of DNA nanoscience Kenneth Douglas has thus done a double service—to science as well as to its public image. I believe that the reception of the book will do justice to the meticulous research and artistry of this tome.'– Rudolf Podgornik (Jožef Stefan Institute)Journal of Biological Physics (August 2016), DOI: 10.1007/s10867-016-9425-4.Table of ContentsA Note to the ReaderPrefaceAuthor BiographyAcknowledgmentsINTRODUCTION: Grandma Needs a WalkerPART I — The Story Line and Its UnderpinningsCHAPTER ONE — Down the Road and the GemischDramatis Personae, Part I: Nadrian SeemanMolecular Crystals—Inspiration from EscherPerspiration and ReinventionDramatis Personae, Part II: Noel Clark, Tommaso BelliniLiquid Crystals and Self-AssemblySeeman, Bellini and Clark, and Base ComplementarityConventional Wisdom and an Alternative ViewEndnotesCHAPTER TWO — DNA: The Molecule That Makes Life Work—and MoreErwin ChargaffRosalind FranklinJames Watson, Francis Crick, and Maurice WilkinsDNA SequencingPolyacrylamide Gel Electrophoresis (PAGE)DNA SynthesisExercises for Chapter TwoEndnotesCHAPTER THREE — Travels to the NanoworldThe Scanning Tunneling Microscope (STM)Moving Atoms With an STMStanding WavesQuantum CorralsNanomethodologySpherical Nucleic Acids (SNAs)Biodiagnostic Detection Using SNAsExercises for Chapter ThreeEndnotesCHAPTER FOUR—Liquid Crystals: Nature’s Delicate Phase of MatterPhase TransitionsClasses of Liquid CrystalsCell Membranes and the Langmuir TroughMicellesLiquid Crystal DisplaysExercises for Chapter FourEndnotesCHAPTER FIVE — Tools of the TradePolarized Light MicroscopyLiquid Crystal Texture Seen Through a Depolarized Light MicroscopeTransmission Electron Microscopy (TEM)Atomic Force Microscopy (AFM)X-Ray Diffraction and Bragg’s LawThe Phase ProblemSynchrotron X-Ray DiffractionExercises for Chapter FiveEndnotesPART II — The Emerging Technology: Nanomaterials Constructed From DNACHAPTER SIX — The Three Pillars of Structural DNA NanotechnologyBranched DNA and DNA JunctionsSticky EndsImmobile Four-Arm DNA JunctionTwo-Dimensional Ligation of DNA JunctionsDeconstruction of Concatenated Nucleic Acid JunctionsMacrocyclesThree-Dimensional Constructions and CatenanesThe DNA CubeExercises for Chapter SixEndnotesCHAPTER SEVEN — Motif Generation, Sequence Design, Nanomechanical DevicesFlexible Junctions ReduxThe Double-Crossover (DX) MoleculeDesign and Self-Assembly of Two-Dimensional DNA CrystalsTwo-Dimensional Nanoparticle ArraysSequence DesignNanomechanical DevicesExercises for Chapter SevenEndnotesCHAPTER EIGHT—DNA Origami, DNA BricksScaffolded DNA OrigamiDNA Origami PatternsStrand Invasion also called Strand DisplacementDNA Origami With Complex Curvatures in Three DimensionsDNA Tiles in Two DimensionsDNA Bricks in Three DimensionsDNA Brick Shapes in Three DimensionsDNA Brick CrystalsSeeman, Rothemund, and YinExercises for Chapter EightEndnotesCHAPTER NINE — DNA Assembly Line and the Triumph of Tensegrity TrianglesDNA Nanoscale Assembly Line (Overview)DNA WalkersDNA Machines and Paranemic Crossover MoleculesDNA Cassette With Robot Arm and DNA Origami TrackDNA Assembly LineThe Triumph of Tensegrity TrianglesExercises for Chapter NineEndnotesBRIEF INTERLUDE I — Back to MethuselahMolecular-Scale WeavingMoors and Crossover MoleculesTensegrity SculptingMayan Pottery, Chirality, and the Handedness of LifeEndnotesCHAPTER TEN — DNA Nanotechnology Meets the Real WorldCell Membrane ChannelsSynthetic Membrane Channels via DNA NanotechnologyCurrent GatingChannels as Single-Molecule SensorsMolecular Nanorobots Built by DNA Origami: Cell-Targeted Drug DeliveryTests of Nanorobot FunctionTest of Binding Discrimination: Healthy Cells vs. Leukemia Cells (NK Cells)Exercises for Chapter TenEndnotesPART III — The Possible Origins of Life’s Information CarrierCHAPTER ELEVEN — Chance FindingsOnsager’s Criterion for an Isotropic-Nematic Liquid Crystal Phase TransitionNanoDNA Seems to Violate Onsager’s Venerable CriterionThe DetailsShifting GearsPhase Separation into Liquid Crystal DropletsThe Depletion InteractionFlory’s ModelExercises for Chapter ElevenEndnotesCHAPTER TWELVE — Unexpected ConsequencesHierarchical Self-AssemblyNanoRNABlunt Ends and Sticky EndsBase Stacking ForcesThe Scope of the Self-Assembly Mechanisms of Nucleic AcidsRandom-Sequence NanoDNAThe Strange World of Random-Sequence NanoDNALiquid Crystal Ordering of Random-Sequence NanoDNANon-Equilibrium Statistical Mechanics: Kinetic Arrest and Nonergodic BehaviorExercises for Chapter TwelveEndnotesCHAPTER THIRTEEN — Ligation: Blest be the Tie That BindsNanoDNA Stacking: Weak Physical Attractive Forces vs. Chemical LigationAbiotic Ligation Experiments with EDCThe Scheme: Polyethylene glycol (PEG)-Induced Phase SeparationGel Electrophoresis of D1p Oligomers With Polyacrylamide and Agarose GelsAnother Stellar Contribution by Chemist Paul J. FloryAnalysis of Gel Profiles: The Experimental Data is Well Described by the Flory ModelThe Lowdown on Ligation EfficiencyThe Liquid Crystal Phase as GatekeeperCascaded Phase SeparationExercises for Chapter ThirteenEndnotesBRIEF INTERLUDE II — The Handedness of LifeChiralityLife is HomochiralMacroscopic Chiral Helical Precession of Molecular OrientationBellini and Clark Examine NanoDNA ChiralityA Lighter Take on ChiralityExercises for Brief Interlude IIEndnotesCHAPTER FOURTEEN — All the World’s a Stage and Life’s a Play—Did it Arise From Clay?Emergence and ComplexityMiller-Urey ExperimentRNA World HypothesisOther Plausible VenuesReplicator-First vs. Metabolism-FirstFeats of ClayThe Lipid WorldLiquid Crystals in the Work of Deamer and the Work of Bellini/ClarkManfred Eigen and Stuart KauffmanExercises for Chapter FourteenEndnotesCHAPTER FIFTEEN — The Passover Question: Why is This Origins Proposal Different From All Other Proposals?Emergence and Broken SymmetryAbout-FaceOccam’s RazorThe RNA World RevisitedSticky Business, Part I: What Constitutes Plausible Prebiotic Conditions?Sticky Business, Part II: The Origins Question—Whose Home Turf Is It?Discovering the Physical Processes that Enabled the Chemistry of LifeMetabolism-First RevisitedComputer Simulations and Mathematical ModelingAn Ancient "Liquid Crystal World"EndnotesEpilogueAPPENDIX — Texture of Liquid Crystal Optical ImagesSmectic Phase Liquid Crystal TextureBent-Core MoleculesExtinction BrushesChiral Nematic Texture of NanoDNA Liquid CrystalsColumnar Texture of NanoDNA Liquid CrystalsEndnotesGlossaryIndex

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Book SynopsisForensic document examination is the study of physical evidence and physical evidence cannot lie. Only its interpretation can err. Only the failure to find it, or to hear its true testimony can deprive it of its value.âRoy Huber This is a comprehensive update of Huber and Headrick's seminal work on handwriting examination. New coverage includes a review of forensic handwriting examination research, handwriting analysis training and proficiency, revised methods and procedures, an updated listing and clarification of terminology and electronic signatures, the analysis of digitized handwriting, and other related technological advances. The book includes updated photographs, several added illustrations, and advances in techniques based on the scientific research conducted in the area over the last 20 years.Features of the new edition include: The latest on electronic signatures, digital handwriting, automated handwriting verification, and the many advances in tTable of ContentsIntroduction. The World of Documents. 1. History of Forensic Document Examination 2. The Development of Handwriting 3. The Discrimination of Handwriting 4. Premises for the Identification of Handwriting 5. Fundamentals of the Identification Process 6. Discrimination and Identification of Handwriting 7. Special Problems in the Discrimination and Identification of Writing 8. Extrinsic Factors Influencing Handwriting 9. Intrinsic Factors Influencing Handwriting 10. Requirements and Results 11. The Diagnosis of Handwriting Identification 12. Handwriting, Document Analysis, and Electronic Media 13. Evaluating Document Examiner Competency 14. Science and Handwriting Identification 15. Terminology References Appendix A

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Book SynopsisThroughout history, there has been an intrinsic need for humans to detect deception in other humans. Developed in 1923, the polygraph machine was a tool designed to do just this. To date, there have been many improvements made to the basic polygraph instrument. This book outlines the instrumentation as well as the latest in questioning techniques and methods available to the professional interviewer to determine truth from deception. The book covers psychology and physiology, a history of polygraph with the advances of leading figures, question formulation, data analysis, legal implications and legal cases, and the author's developed technique Integrated Zone Comparison Technique (IZCT).Table of ContentsPolygraph History. Question Formulation. Technique Development. Integrated Zone Comparison Technique (IZCT). The Pre-Test Interview. Data Analysis. Pre-Employment Testing. Report Writing. Legal Cases. Ethics and Standards. Research.

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Book SynopsisThose tasked with investigating death scenes come from a variety of backgrounds and varying levels of experience. Whether a homicide detective, crime scene investigator, medico-legal death investigator, coroner or medical examiner, Death Scene Investigation: Procedural Guide, Second Edition provides the investigator best-practice techniques and procedures for almost any death scene imaginable, including for deaths occurring even under the most unusual of circumstances.This Second Edition is fully updated to include new coverage on shallow graves, human remains at crime scenes, poisonings, expanded coverage of projectile weapons, videography, touch DNA, death notifications, and a newly added chapter dedicated to sexual deaths. In addition, the book serves as an on-scene ready reference which includes instructions on procedure including the initial notification of a death, processing the scene and body, the investigator''s role at autopsy, and analyzing Table of ContentsSection 1: Death Scene Investigation 1. Death Scene Response 2. Natural Deaths 3. Accidental Deaths 4. Suicidal Deaths 5. Homicidal Deaths Section 2: The Medicolegal Death Investigation 6. The Role of the Medicolegal Death Investigator 7. The Role of the Coroner 8. The Role of the Medical Examiner 9. Autopsy Protocol and the Investigator’s Role Section 3: Recovery of Human Remains 10. Searching for Human Remains 11. Surface Recovery of Human Remains 12. Recovery of Buried Human Remains 13. Aquatic Recovery of Human Remains 14. Post Mortem Changes Section 4: Wound Dynamics and Mechanisms of Injury 15. Asphyxiation 16. Sharp Force Injuries 17. Blunt Force Injuries 18. Chopping Injuries 19. Firearm Injuries – Rifle and Pistol 20. Firearm Injuries – Shotgun 21. Explosive Injuries 22. Thermal Injuries 23. Electrical Injuries 24. Poisoning 25. Drug Related Deaths Section 5: Special Death Investigations 26. Infant Death 27. Child Deaths 28. Child Sexual Abduction and Murder 29. Sexual Activities Resulting in Death 30. Rape and Sexual Assault Resulting in Death 31. Multiple Victim Death Scenes Section 6: Death Scene Management, Tasks and Responsibilities 32. Death Scene Management 33. Death Scene Sketching 34. Death Scene Photography 35. Death Scene Videography 36. Death Scene Notes and Observation Section 7: Death Scene Evidence Processing 37. Documenting and Processing Bloodstain Patterns at the Scene 38. Documenting and Processing the Shooting Scene 39. Documenting and Processing the Post Blast Scene 40. Entomological Evidence 41. Biological Evidence 42. Trace Evidence 43. Friction Ridge Evidence 44. Impression Evidence Section 8: Death Investigation Checklist Appendix A: Bloodborne Pathogens Appendix B: Bloodstain Pattern Decision Matrix Appendix C: Druggust Fold

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Book SynopsisAround the World, metal pollution is a major problem. Conventional practices of toxic metal removal can be ineffective and/or expensive, delaying and exacerbating the crisis. Those communities dealing with contamination must be aware of the fundamentals advances of microbe-mediated metal removal practices because these methods can be easily used and require less remedial intervention. This book describes innovations and efficient applications for metal bioremediation for environments polluted by metal contaminates.Table of ContentsIntroduction to metal contamination and Environmental Issues. Metals and their toxic effects: An introduction to the noxious elements. Sources of metal pollution, global status and conventional remediation practices. Microbes: The natural scavengers and their role in metal bioremediation. Havocs of toxic metal contaminations: unforgettable stories. Metal-microbe interactions. Evolution of inherent biochemical pathways in microorganisms in metal contaminated environments. Enzyme catalysed microbial transformations of metals. Cellular and genetic machineries of metal resistance in microbes (the role of plasmids, genomic DNA, transposons and other genetic elements). Biosorption of metals by microorganism: bacteria, fungi, algae, actinobacteria. Metal binding proteins and peptides and their role in bioremediation. Bacterial exopolysaccharides in metal removal. Molecular approaches in metal bioremediation. Genetic engineering for enhanced metal remediation by microbes. Novel metabolic pathways for toxic metal removal from the contaminated environment. Introduction of heterologous microbial Metallothioneins into transgenic plants for metal removal. Genetically modified biosorbents for toxic metal removal. GMOs in natural environment and strategies to increase their survivability and stability. Bacterial biofilm and genetic regulation in metal detoxification. Interdisciplinary approaches for enhanced metal bioremediation. Interaction between metals, microbes and plants. Immobilization techniques for bioremediation of metals. Bioreactor based approaches of toxic metal removal. Computer aided studies in metal bioremediation. Bacterial mediated nanoparticle synthesis and their role in bioremediation. Specific metal bioremediation Studies. Investigation on arsenic accumulating and transforming bacteria for potential use in bioremediation. Elucidation of cadmium resistance gene in Cadmium resistant bacteria for utilization in bioremediation. Bioremediation of copper present in waste water using copper resistant microorganisms. Bioremediation of mercury and importance of bacterial mer genes: A biotechnology approach. Suitability of nickel resistant microbes for the use in enhanced nickel bioremediation. Efficacy of microbial entities with lead resistant genotype for in-situ bioremediation of lead contaminated sites. Zinc biosorption and subsequent mineralization/transformation by the microbial species for bioremediation of zinc. Bioremediation of chromium solutions and chromium containing waste waters. Harnessing radiation inducible promoter and gene clusters of microorganisms for enhanced precipitation of radioactive waste. Assessment of diversity and bioremediation potential of mercury resistant marine bacteria in Bay of Bengal, Odisha, India.

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Book SynopsisThe global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the Table of ContentsBackground. Pretreatment of biomass. Transport of nutrients and carbon catabolite repression for the selective carbon sources. Catabolite regulation of the main metabolism. Metabolic regulation in response to growth environment. Metabolic engineering for the production of a variety of biofuels and biochemical. Biofuel and biochemical production by photosynthetic organisms. Systems biology approach and modeling. References. Appendix A.

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Book SynopsisExome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.Trade Review"This book represents a timely contribution to the burgeoning field of exome and genome sequencing data analysis. It covers all pertinent topics ranging from raw data quality control to medical interpretation of genetic mutations, with detailed command line examples as well as in-depth explanations on every step of analysis. Highly recommended to any researchers, scientists, clinicians or students who are interested to learn practical skills on genome analysis."-Kai Wang, Department of Biomedical Informatics, Columbia University"This book provides a very comprehensive overview of all the fundamentals that are needed to work as a bioinformatician in the field of exome and genome analysis. All of the important processing steps are illustrated with practical examples and code. In addition, the casual writing style makes this book an easy read."-Christian Gilissen, Department of Human Genetics, Radbound Univeristy Medical Center "This book is an excellent example of a hybrid between a textbook and an up-to-date research reference on the latest bioinformatics tools available in this eld. Its rigorous and thorough approach makes it a reliable starting point for bioinformaticians and biologists. By including details on methodological aspects of some of the algorithms used for various components of the data analysis and coupling these with fully-commented examples and exercises, this book presents itself as a must-have for novices and experts alike. Given the fast pace of the field, no book can be exhaustive, however, the wide variety of tools presented here recommend it to a wide audience, both as expertise and focused research interests."-Irina Ioana Mohorianu, Zentralblatt MATH"This book represents a timely contribution to the burgeoning field of exome and genome sequencing data analysis. It covers all pertinent topics ranging from raw data quality control to medical interpretation of genetic mutations, with detailed command line examples as well as in-depth explanations on every step of analysis. Highly recommended to any researchers, scientists, clinicians or students who are interested to learn practical skills on genome analysis."-Kai Wang, Department of Biomedical Informatics, Columbia University"This book provides a very comprehensive overview of all the fundamentals that are needed to work as a bioinformatician in the field of exome and genome analysis. All of the important processing steps are illustrated with practical examples and code. In addition, the casual writing style makes this book an easy read."-Christian Gilissen, Department of Human Genetics, Radbound Univeristy Medical Center "This book is an excellent example of a hybrid between a textbook and an up-to-date research reference on the latest bioinformatics tools available in this eld. Its rigorous and thorough approach makes it a reliable starting point for bioinformaticians and biologists. By including details on methodological aspects of some of the algorithms used for various components of the data analysis and coupling these with fully-commented examples and exercises, this book presents itself as a must-have for novices and experts alike. Given the fast pace of the field, no book can be exhaustive, however, the wide variety of tools presented here recommend it to a wide audience, both as expertise and focused research interests."-Irina Ioana Mohorianu, Zentralblatt MATHTable of ContentsIntroduction. Whole Exome and Genome Sequencing. NGS Technology. Illumina Technology. Obtaining WES/WGS Data for this book. Raw Data Processing. FASTQ Format. Raw Data: Quality Control. Trimming. Alignment. Alignment: Mapping reads to the reference genome. SAM/BAM Format. Postprocessing the Alignment. Alignment Data: Quality control. Variant Calling. Variant Calling & Quality-based Filtering. Variant Call Format. Jannovar. Variant Annotation. Variant Calling: Quality Control. Integrative Genomics Viewer (IGV): Visualizing Alignments and Variants. De novo variants. Structural variation. Variant Filtering. Pedigree and Linkage Analysis. Intersection Analysis and Rare Variant Association Studies. Variant Frequency Analysis. Variant Pathogenicity Prediction. Prioritization. Variant Prioritization. Prioritization by Random Walk Analysis. Phenotype Analysis. Exomiser and Geniomiser. Medical Interpretation. Cancer. A (Very) Short Introduction to Cancer. Somantic variants in cancer. Tumor Evolution and Sample Purity. Driver Mutations and mutational signatures.

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Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.

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Book SynopsisNeed quick review and practice to help you excel in Biology?Barron’s Biology Practice Plus features more than 400 online practice questions and a concise review guide that covers the basics of Biology. Inside you’ll find: Concise review on the basics of Biology—an excellent resource for students who want a quick review of the most important topics Access to 400+ online questions arranged by topic for customized practice Online practice includes answer explanations with expert advice for all questions plus scoring to track your progress This essential guide is the perfect practice supplement for students and teachers!

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Book SynopsisExam Board: EdexcelLevel: IGCSESubject: ScienceFirst Teaching: September 2017First Exam: June 2019Build students' knowledge with in-depth yet accessible scientific content.- Test understanding with study questions throughout the book- Prepare students for the exam with sample answers and expert comments plus exam-style questions for every section- Build practical skills with coverage of all required practicals plus further suggested experiments- Develop mathematical skills with helpful tips throughout - Challenge higher ability students with extension 'extend and challenge' activities - Answers to all activities freely available online

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Book SynopsisEnsure your students get to grips with the practical and skills needed to succeed at AS and A Level Biology. With an in-depth assessment-driven approach that builds and reinforces understanding; clear summaries of practical work with sample questions and answers help to improve exam technique in order to achieve higher grades.Written by experienced teacher John Campton, this Student Guide for practical Biology:- Help students easily identify what they need to know with a concise summary of practical work examined in the A-level specifications.- Consolidate understanding of practical work, methodology, mathematical and other skills out of the laboratory with exam tips and knowledge check questions, with answers in the back of the book.- Provide plenty of opportunities for students to improve exam technique with sample answers, examiners tips and exam-style questions. - Offer support beyond the Student books with coverage of methodologies and generic practical skills not focused on in the textbooks.

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Book SynopsisExam Board: AQA, CCEA, Edexcel, OCR, WJEC/Eduqas Level: A-level Subject: Biology First teaching: September 2015 First exams: Summer 2017Master the skills you need to set yourself apart and hit the highest grades; this year-round course companion develops the higher-order thinking skills that top-achieving students possess, providing step-by-step guidance, examples and tips for getting an A grade.Written by experienced author and teacher Jo Ormisher, Aiming for an A in A-level Biology:- Helps you develop the 'A grade skills' of analysis, evaluation, creation and application- Takes you step by step through specific skills you need to master in A-level Biology, including scientific reading, quantitative and practical skills , so you can apply these skills and approach each exam question as an A/A* candidate- Clearly shows how to move up the grades with sample responses annotated to highlight the key features of A/A* answers- Helps you practise to achieve the levels expected of top-performing students, using in-class or homework activities and further reading tasks that stretch towards university-level study- Perfects exam technique through practical tips and examples of common pitfalls to avoid - Cultivates effective revision habits for success, with tips and strategies for producing and using revision resources- Supports all exam boards, outlining the Assessment Objectives for reaching the higher levels under the AQA, Edexcel, OCR, WJEC/Eduqas and CCEA specifications

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Book SynopsisExam board: International BaccalaureateLevel: IB DiplomaSubject: BiologyFirst teaching: September 2014First exams: Summer 2016Aim for the best Internal Assessment grade with this year-round companion, full of advice and guidance from an experienced IB Diploma Biology teacher.- Build your skills for the Individual Investigation with prescribed practicals supported by detailed examiner advice, expert tips and common mistakes to avoid.- Improve your confidence by analysing and practicing the practical skills required, with comprehension checks throughout.- Prepare for the Internal Assessment report through exemplars, worked answers and commentary. - Navigate the IB requirements with clear, concise explanations including advice on assessment objectives and rules on academic honesty.- Develop fully rounded and responsible learning with explicit reference to the IB learner profile and ATLs.

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Book SynopsisExam Board: SQA Level: Higher Subject: Biology First Teaching: August 2018 First Exam: May 2019Get your best grade with comprehensive course notes and advice from Scotland's top experts, fully updated for the latest changes to SQA Higher assessment.How to Pass Higher Biology Second Edition contains all the advice and support you need to revise successfully for your Higher exam. It combines an overview of the course syllabus with advice from top experts on how to improve exam performance, so you have the best chance of success.- Revise confidently with up-to-date guidance tailored to the latest SQA assessment changes - Refresh your knowledge with comprehensive, tailored subject notes- Prepare for the exam with top tips and hints on revision techniques- Get your best grade with advice on how to gain those vital extra marks

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Book SynopsisDevelop experimental, analytical and evaluation skills with topical biology examples, practical assessment guidance and differentiated end-of-topic questions in this updated, all-in-one textbook for Years 1 and 2.Written for the AQA A-level Biology specification, this revised textbook will: - Provide support for all 12 required practicals with plenty of activities and data analysis guidance.- Develop understanding with engaging and contemporary examples to help you apply your knowledge, analyse data and evaluate findings.- Give detailed guidance on the mathematical skills needed with support throughout, examples of method and a dedicated 'Developing mathematical skills' chapter.- Offer regular opportunities to test understanding with 'Test yourself' questions, differentiated end-of-topic questions and 'Stretch and challenge' questions.- Support exam preparation with synoptic questions, revision tips and skills.- Develop understanding with free online access to 'Test yourself' answers, 'Practice' questionanswers and extended glossaries*.

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Book SynopsisSupports Pearson Edexcel Level 3 Advanced GCE in Biology B (9BI0) specification.Build investigative skills, test understanding and apply biological theory to topical examples with the updated, all-in-one textbook for Years 1 and 2.Combining everything your students need to know for the Pearson Edexcel A level Biology B specification, this revised textbook will:- Support all 16 required practicals with activities and questions to help students explain procedures, analyse data and evaluate results.- Provide clear definitions, as well as explanations, of the meanings of all technical vocabulary needed for the specification.- Help bring students up to speed with a summary of prior knowledge and diagnostic questions at the start of each chapter.- Offer assessment guidance with exam practice questions at the end of each chapter, graded by difficulty to support progression.- Stretch more able students with new extended response and 'Challenge' questions.- Build mathematical skills with a dedicated 'Maths for Biology' chapter and support throughout, explaining key concepts and methods.- Develop and embed understanding with end-of-chapter summaries, free online access to 'Test yourself' answers and an extended glossary.

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Book SynopsisGet to grips with the core practicals and develop the skills students need to succeed with an assessment-driven approach, combining clear summaries of practical work that reinforce understanding, with sample questions and answers to improve exam technique. - Easily identify what students need to know with a concise summary of the required practical work examined in the A-level specifications. - Consolidate understanding of practical work, methodology, mathematical and other skills out of the laboratory with exam tips and knowledge check questions, with answers in the back of the book. - Improve exam technique with sample answers, examiner's tips and exam-style questions. - Provide extra support with coverage of methodologies and generic practical skills not focused on in the textbooks.

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Book SynopsisHow grids paved the way for our biological understanding of organisms As one of the most visual sciences, biology has an aesthetic dimension that lends force and persuasion to scientific arguments: how things are arranged on a page, how texts are interspersed with images, and how images are composed reflect deep-seated beliefs about how life exists on Earth. Biology in the Grid traces how our current understanding of life and genetics emerged from the pervasive nineteenth- and twentieth-century graphic form of the grid, which allowed disparate pieces of information to form what media theorist Vilém Flusser called “technical images.”Phillip Thurtle explains how the grid came to dominate biology in the twentieth century, transforming biologists’ beliefs about how organisms were constructed. He demonstrates how this shift in our understanding of biological grids enabled new philosophies in endeavors such as advertising, entertainment, and even political theory. The implications of the arguments in Biology in the Grid are profound, touching on matters as fundamental as desire, our understanding of our bodies, and our view of how society is composed. Moreover, Thurtle’s beautifully written, tightly focused arguments allow readers to apply his claims to new disciplines and systems. Bristling with insight and potential, Biology in the Grid ultimately suggests that such a grid-organized understanding of natural life inevitably has social and political dimensions, with society recognized as being made of interchangeable, regulated parts rather than as an organic whole.Trade Review"Phillip Thurtle paves the way. Combining crucial insights from media theory and science history, he transforms our saturated understanding of ‘biopolitics’ into a fresh and forceful analysis uncovering the political economy of today’s life sciences. For all of us interested in epistemic media, critical vitalism, and interventionist thought, Biology in the Grid is compulsory reading."—Henning Schmidgen, Bauhaus University Weimar"The book is fascinating, detailed, and deserves to be taken seriously in the philosophy of design. The writing is clear and accessible, and the illustrations well chosen to support Thurtle's points." —CHOICETable of ContentsIntroduction: The Varieties of Gridded Experience1. Life on the Line: Organic Form2. Envisioning Grids3. Warped Grids: Pests and the Problem of Order4. Modulations: Envisioning Variations5. Drawing Together: Composite Lives and Liquid RegulationsEpilogue: Toward the Nonsynthetic Care of the Molecular SelfAcknowledgments

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Book SynopsisThe future is sh*t: the literal kind. For most of human history we've been, well, disinclined to take a closer look at our body's natural product-the complex antihero of this story-save for gleaning some prophecy of our own health. But if we were to take more than a passing look at our poop, we would spy a veritable cornucopia of possibilities. We would see potent medicine, sustainable power, and natural fertilizer to restore the world's depleted lands. We would spy a time capsule of evidence for understanding past lives and murderous ends. We would glimpse effective ways of measuring and improving human health from the cradle to the grave, early warnings of community outbreaks like Covid-19, and new means of identifying environmental harm-and then reversing it.Flush is both an urgent exploration of the world's single most squandered natural resource, and a cri de coeur (or cri de colon?) for the vast, hidden value in our "waste." Award-winning journalist and microbiologist Bryn Nelson, PhD, leads readers through the colon and beyond with infectious enthusiasm, helping to usher in a necessary mental shift that could restore our balance with the rest of the planet and save us from ourselves. Unlocking poop's enormous potential will require us to overcome our shame and disgust and embrace our role as the producers and architects of a more circular economy in which lowly byproducts become our species' salvation. Locked within you is a medicine cabinet, a biogas pipeline, a glass of drinking water, a mound of fuel briquettes; it's time to open the doors (carefully!). A dose of medicine, a glass of water, a gallon of rocket fuel, an acre of soil: sometimes hope arrives in surprising packages.

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Book SynopsisHumans are storytelling animals. Stories are what make our societies possible. Countless books celebrate their virtues. But Jonathan Gottschall, an expert on the science of stories, argues that there is a dark side to storytelling we can no longer ignore. Storytelling, the very tradition that built human civilization, may be the thing that destroys it.In The Story Paradox, Gottschall explores how a broad consortium of psychologists, communications specialists, neuroscientists, and literary quants are using the scientific method to study how stories affect our brains. The results challenge the idea that storytelling is an obvious force for good in human life. Yes, storytelling can bind groups together, but it is also the main force dragging people apart. And it's the best method we've ever devised for manipulating each other by circumventing rational thought. Behind all civilization's greatest ills-environmental destruction, runaway demagogues, warfare-you will always find the same master factor: a mind-disordering story.Gottschall argues that societies succeed or fail depending on how they manage these tensions. And it has only become harder, as new technologies that amplify the effects of disinformation campaigns, conspiracy theories, and fake news make separating fact from fiction nearly impossible.With clarity and conviction, Gottschall reveals why our biggest asset has become our greatest threat, and what, if anything, can be done. It is a call to stop asking, "How we can change the world through stories?" and start asking, "How can we save the world from stories?"

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Book Synopsis

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Book Synopsis

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Book SynopsisLearn to produce crops with improved nutrition to alleviate malnourishment--using sustainable agriculture techniques!Utilizing complete food systems to improve nutrition has become a priority in the fight against malnutrition. This book examines all aspects of food systems, drawing on examples from various countries and geographical regions. Bringing together the most recent work of international experts, Food Systems for Improved Human Nutrition provides an important overview of the food systems approach. It also explores the extent of malnourishment in different areas; presents case studies from South Asia, China, India, Bangladesh, and East Africa; points to ways to improve food production and nutrient quality; and suggests directions for future research. Helpful charts and tables make the information in this well-referenced book easy to access and understand.Food Systems for Improved Human Nutrition brings you state-of-the-art information on: the potential benefits of agroforestry systems how to fortify food with micronutrients how to design population-appropriate nutrition interventions the ways that rapid economic change can affect human nutrition in a given area biotech approaches to improve nutrition in rice and maize crops crossbred cow technologies in the East African highlands and much more! Table of ContentsPreface , Foreword , Food Systems for Improved Human Nutrition: An Introduction , Food Systems and Malnutrition: Linking Agriculture, Nutrition, and Productivity , Food-Based Approaches for Alleviating Micronutrient Malnutrition: An Overview , Effects of Micronutrient Deficiencies on Human Health: Its Status in South Asia , Rapid Economic Change, the Nutrition Transition and Its Effects on the Structure of Consumption: The Nutrition Transition in China , Shifts in Cropping System and Its Effect on Human Nutrition: Case Study from India , Nutritional and Economic Benefits of Enhanced Vegetable Production and Consumption , Agroforestry Systems for Food and Nutrition Security?Potentials, Pathways, and Policy Research Needs , Quality Protein Maize: Overcoming the Hurdles , Improving Rice to Meet Food and Nutritional Needs: Biotechnological Approaches , Changing Significance of Inland Fisheries for Livelihoods and Nutrition in Bangladesh , Adoption of Crossbred Cow Technologies and Increased Food Security Among Smallholder Dairy Farmers in the East African Highlands , Delivering Micronutrients via Food Fortification , Designing Nutrition Interventions with Food Systems: Planning, Communication, Monitoring, and Evaluation , Food Systems Approach for Sustainable Nutrition Security: A Synthesis and Way Forward , Index , Reference Notes Included ,

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Book SynopsisComplete, Authoritative, Unrivaled CollectionClin-Alert, long established as the pre-eminent source of adverse drug reaction/interaction, now brings you Clin-Alert 2000. Presented in a quick reference format, Clin-Alert 2000 allows very easy access by drug class for comparison reports. Pharmacological classes are arranged based on a modified AHFS Therapeutic Classification Code System AND include the addition of a comprehensive section on alternative/herbal medicines.Table of ContentsDrug Classes Include: Alternative Therapies (herbals, supplements). Antihistamines. Anti-infective Agents. Anti-neoplastics. Autonomic Drugs. Blood Formation and Coagulation. Cardiovascular Drugs. CNS Agents (Analgesics, Sedatives, Psychotherapeutics). Dental Agents. Diagnostic Agents. Electrolytic and Water Balance. EENT Preparations. Gastrointestinal Agents. Hormones and Contraceptives. Radioactive Agents. Topical Products. Vaccines. Vitamins. Miscellaneous.

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Book SynopsisThe field of transplantation continues to evolve. In the years since the first publication of the Transplantation Drug Pocket Reference Guide, the therapeutic armamentarium for transplantation has grown. The introduction of new agents continues to enhance our ability to improve the short- and long-term success of transplantation. The fifth edition of the guide, now entitled Transplantation Drug Manual, includes information on agents approved for use in transplant recipients. As in previous editions, we compiled practical information on the wide array of pharmaceutical agents currently available–both those used for immunosuppression and those used to minimize posttransplant complications. The agents described here are the most frequently prescribed drugs in the Transplant Service at the University of Wisconsin. We hope you find this information to be useful and practical in managing the transplant patient.Table of Contents1. Working Guide to Immunosuppression 2. Antimicrobials 3. Cardiovascular Agents 4. Antiosteoporosis Agents 5 Antiplatelets 6. Diabetes Agents 7. Ulcer Prophylaxis and Treatment 8. Diuretics 9. Other Concomitant Agents

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