Biology, life sciences Books
Technomic Publishing Co ,U.S. Pharmacokinetic Analysis: A Practical Approach
Book SynopsisThis insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner.The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.
£999.99
Taylor & Francis Inc Clin-Alert 2000
Book SynopsisComplete, Authoritative, Unrivaled CollectionClin-Alert, long established as the pre-eminent source of adverse drug reaction/interaction, now brings you Clin-Alert 2000. Presented in a quick reference format, Clin-Alert 2000 allows very easy access by drug class for comparison reports. Pharmacological classes are arranged based on a modified AHFS Therapeutic Classification Code System AND include the addition of a comprehensive section on alternative/herbal medicines.Table of ContentsDrug Classes Include: Alternative Therapies (herbals, supplements). Antihistamines. Anti-infective Agents. Anti-neoplastics. Autonomic Drugs. Blood Formation and Coagulation. Cardiovascular Drugs. CNS Agents (Analgesics, Sedatives, Psychotherapeutics). Dental Agents. Diagnostic Agents. Electrolytic and Water Balance. EENT Preparations. Gastrointestinal Agents. Hormones and Contraceptives. Radioactive Agents. Topical Products. Vaccines. Vitamins. Miscellaneous.
£194.75
Hanser Fachbuchverlag Biointelligence
Book Synopsis
£112.49
Taylor & Francis Inc Transplantation Drug Manual
Book SynopsisThe field of transplantation continues to evolve. In the years since the first publication of the Transplantation Drug Pocket Reference Guide, the therapeutic armamentarium for transplantation has grown. The introduction of new agents continues to enhance our ability to improve the short- and long-term success of transplantation. The fifth edition of the guide, now entitled Transplantation Drug Manual, includes information on agents approved for use in transplant recipients. As in previous editions, we compiled practical information on the wide array of pharmaceutical agents currently available–both those used for immunosuppression and those used to minimize posttransplant complications. The agents described here are the most frequently prescribed drugs in the Transplant Service at the University of Wisconsin. We hope you find this information to be useful and practical in managing the transplant patient.Table of Contents1. Working Guide to Immunosuppression 2. Antimicrobials 3. Cardiovascular Agents 4. Antiosteoporosis Agents 5 Antiplatelets 6. Diabetes Agents 7. Ulcer Prophylaxis and Treatment 8. Diuretics 9. Other Concomitant Agents
£90.24
John Wiley and Sons Ltd Natural Compounds and Their Role in Apoptotic
Book SynopsisApoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. This book reviews the main effects of natural compounds on the different apoptotic signaling pathways, including the intrinsic and extrinsic apoptosis pathways, the NF-kB-mediated pathway, the PI3K/Akt signaling, and other main pathways. Among the topic specially covered are: Effects of natural compounds on cancer cells Natural compounds as inducers of cell death Diet in health and disease Inflammation and cancer Natural compounds as kinase inhibitors Natural compounds in neurodegenerative diseases Natural compounds as inhibitors of ROS NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Trade Review"An essential guide to further study in this field." (Business & Finance Ireland, November 2009)
£129.58
John Wiley and Sons Ltd Resveratrol and Health, Volume 1215
Book SynopsisThis volume examines the phytoalexin resveratrol and the ongoing studies about its effects on lifespan and health. Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi, significantly extends the lifespan of the yeast Saccharomyces cerevisiae, Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Resveratrol is currently a topic of numerous animal and human studies into its effects. The effects of resveratrol on the lifespan of many model organisms remain controversial. Anti-cancer, anti-inflammatory, blood-sugar-lowering, and other beneficial cardiovascular effects of resveratrol have been reported in experiments with mouse and rat model systems. However, most of these results have yet to be replicated in humans. Resveratrol is found in the skin of red grapes and is a constituent of red wine. Resveratrol has also been produced by chemical synthesis or by biotechnological synthesis and is sold as a nutritional supplement derived primarily from Japanese knotweed. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please click here. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£90.50
John Wiley and Sons Ltd Molecular and Integrative Physiology of the
Book SynopsisThis volume features invited scholarly papers on the topic of molecular and integrative physiology of the musculoskeletal system by clinician-scientists who work at both the bench and the bedside. In addition to bone physiology, this volume also includes papers on muscle physiology and on new paradigms such as arthritis, crossover therapeutics for bisphosphonates in cancer medicine, bone marrow stem cell research in cardiology, and systems biology and bone pathophysiology. This volume examines the musculoskeletal system a complex network of molecular signaling both within the bone and also among bone, muscle, and other organs, such as the intestine, brain, pancreas, adipose tissue, and pituitary gland. Owing to these complex pathways, there are many novel molecular targets for drug development to treat disorders that have been heretofore overlooked or neglected. These include cachexia, sarcopenia, osteoporosis, and various deconditioned states associated with an array of chronic illnesses. New paradigms of therapeutic interventions can be realized from a systems approach and from the use of crossover therapies. The skeletal system is intensively involved with immunological and hormonal activity, and tapping these resources may provide more effective ways to manage disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please click here. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£113.72
John Wiley and Sons Ltd Glycobiology of the Immune Response, Volume 1253
Book SynopsisCarbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Trade Review“Glycobiology of the Immune Response explores the integration of state-of-the art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system.” (European Journal of Immunology, 1 December 2012) Table of ContentsGlycobiology of immune responses 1 Gabriel A. Rabinovich, Yvette van Kooyk and Brian A. Cobb Multifarious roles of sialic acids in immunity 16 Ajit Varki and Pascal Gagneux Siglecs as sensors of self in innate and adaptive immune responses 37 James C. Paulson, Matthew S. Macauley and Norihito Kawasaki Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation 49 Ari Grigorian, Haik Mkhikian and Michael Demetriou T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival 58 Mary C. Clark and Linda G. Baum Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells 68 Bo Pei, Jose Luis Vella, Dirk Zajonc and Mitchell Kronenberg Gelectins in acute and chronic inflammation 80 Fu-Tong Liu, Ri-Yao Yang and Daniel K. Hsu Mechanisms underlying in vivo polysaccharide-specific immunoglobulin responses to intact extracellular bacteria 92 Clifford M. Snapper CD33-related siglecs as potential modulators of inflammatory responses 102 Paul R. Crocker, Sarah J. McMillan and Hannah E. Richards Sulfated glycans control lymphocyte homing 112 Hiroto Kawashima and Minoru Fukuda Acute phase glycoproteins: bystanders or participants in carcinogenesis? 122 Eugene Dempsey and Pauline M. Rudd Glycans, galectins, and HIV-1 infection 133 Sachiko Sato, Michel Ouellet, Christian St-Pierre and Michel J. Tremblay An evolutionary perspective on C-type lectins in infection and immunity 149 Linda M. van den Berg, Sonja I. Gringhuis and Teunis B. H. Geijtenbeck Integrated approach toward the discovery of glycol-biomarkers of inflammation-related diseases 159 Takashi Angata, Reiko Fuijinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong-Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume and Naoyuki Taniguchi Novel roles for the IgG Fc Glycan 170 Robert M. Anthony, Fredrik Wermeling and Jeffrey V. Ravetch The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? 181 Dianne Cooper, Asif J. Iqbal, Beatrice R, Grittens, Carmela Cervone and Mauro Perretti Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution 193 Robert Sackstein The expanding role of α2-3 sialylation for leukocyte trafficking in vivo 201 Markus Sperandio Beyond glycoproteins as galectin counterreceptors: effector T cell growth control of tumors via ganglioside GM1 206 Robert W. Ledeen, Gusheng Wu, Sabine André, David Bleich, Guillementte Huet, Herbert Kaltner, Jürgen Kopitz and Hans-Joachim Gabius Online only Polarization of host immune responses by helminth-expressed glycans Donald Harn Jr., Smanla Tundup and Leena Srivastava Carbohydrate-recognition in the immune system: contributions of NGL-based microarrays to ligand discovery Ten Feizi Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects Gerardo R. Vasta, Hafiz Ahmed, Mario A. Bianchet, José A. Fernández-Robledo and L. Mario Amzel
£36.95
John Wiley and Sons Ltd Neurosciences and Music IV: Learning and Memory,
Book SynopsisThis volume stems from the conference "The Neurosciences and Music IV: Learning and Memory" held in Edinburgh, Scotland 9–12 June 2011. The volume focuses on four themes: infants and children; adult musicians and non-musicians; disabilities and aging-related issues; and therapy and rehabilitation. Manuscripts cover a range of topics, including the cultural neuroscience of music; memory and learning in music performance; the impact of musical experience on cerebral language processing; and mechanisms of rhythm and meter learning over the life span. The Neurosciences and Music IV will be of interest to not only to neuroscientists, psychologists, and students, but also to clinical neurologists and psychologists, educators, and musicologists. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£109.25
John Wiley and Sons Ltd The Year in Human and Medical Genetics: Inborn
Book SynopsisThe genetic dissection of human primary immunodeficiency is expanding at full speed, in at least two directions. Some investigators pursue the dissection of well-known clinical phenotypes, for which the count of genetic etiologies seems to be endless, whereas others begin the search for inborn errors underlying new phenotypes, infectious and otherwise. The field of primary immunodeficiency is also expanding in other ways, with new therapeutic approaches, and with the care of patients in regions of the world where these diseases were unheard of less than a decade ago. The volume provides an overview of the field of medical genetics and its progress in 2011. This volume focuses on new developments in “primary immunodeficiencies" (PIDs), insights into PID pathophysiology, and PIDs in India and the Middle East.Volume I opens with a dialog between the volume editors on the definition of PIDs; additional papers in this volume focus on PIDs in Latin America, Eastern and Central Europe, North Africa, Turkey, Asia, Iran, and the South Pacific. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£92.70
John Wiley and Sons Ltd Skeletal Biology and Medicine II: Bone and
Book SynopsisThe volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine I. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£59.36
John Wiley and Sons Ltd Blavatnik Awards for Young Scientists 2011,
Book SynopsisThis volume comprises contributions from faculty and postdoctoral finalists of the 2011 New York Academy of Sciences Blavatnik Awards for Young Scientists. The Awards celebrate the excellence of some of the most promising young scientists in New York, New Jersey, and Connecticut by acknowledging their highly innovative, multidisciplinary accomplishments in the life sciences, physical sciences, mathematics, and engineering. Included in this volume are manuscripts of the individual finalists' areas of research, which provide a glimpse of some of today’s most compelling scholarly work. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£57.56
John Wiley and Sons Ltd Hematopoietic Stem Cells VIII
Book SynopsisThis volume stems from the eighth international symposium and workshop entitled "Hematopoietic Stem Cells VIII" held hosted by the University of Tuebingen, Germany in the fall of 2011. The meeting was designed to bring ~30 leading scientists together to discuss the state-of-the-art in the field of hematopoietic stem cells. Topics reviewed in this volume include: differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches; hematopoietic stem cell expansion; TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia; regulatory factors for hematopoietic stem cells; reprogramming factors; immune reconstitution and strategies for rebuilding of the immune system after haploidentical stem cell transplantation; zebrafish xenografts as a tool for in vivo studies on human cancer; enhancing engraftment of cord blood cells; current insights into neutrophil homeostasis; and molecular live cell bioimaging in stem cell research, among others. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. Table of ContentsPreface for Hematopoietic Stem Cells VIII vii Claudia Lengerke, Willem E. Fibbe, John E. Dick, and Lothar Kanz Basic aspects of stem cell biology Epigenetic differences between sister chromatids? 1 Peter M. Lansdorp, Ester Falconer, Jiang Tao, Julie Brind’Amour, and Ulrike Naumann Reprogramming cell fates: insights from combinatorial approaches 7 Carlos-Filipe Pereira, Ihor R. Lemischka, and Kateri Moore Molecular live cell bioimaging in stem cell research 18 Max Endele and Timm Schroeder The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems 28 Stefan Tümpel and K. Lenhard Rudolph Hematopoietic stem cell development and molecular regulation In vivo divisional tracking of hematopoietic stem cells 40 Hitoshi Takizawa and Markus G. Manz Caudal genes in blood development and leukemia 47 Claudia Lengerke and George Q. Daley Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche 55 Kenichi Miharada, Göran Karlsson, Matilda Rehn, Emma Rörby, Kavitha Siva, Jörg Cammenga, and Stefan Karlsson G protein-coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells 63 Robert Möhle and Adriana C. Drost Molecular and functional characterization of early human hematopoiesis 68 Elisa Laurenti and John E. Dick Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche 72 Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Yoshiko Matsumoto, and Toshio Suda Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches 78 Paul P.C. Roozen, Martijn H. Brugman, and Frank J.T. Staal Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets 94 Kavitha Sivasubramaniyan, Daniela Lehnen, Roshanak Ghazanfari, Malgorzata Sobiesiak, Abhishek Harichandan, Elisabeth Mortha, Neli Petkova, Sabrina Grimm, Flavianna Cerabona, Peter de Zwart, Harald Abele, Wilhelm K. Aicher, Christoph Faul, Lothar Kanz, and Hans-Jörg Bühring Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders 107 Maria Ester Bernardo and Willem E. Fibbe Stem cells and cancer TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia 118 Yoshikane Kikushige and Koichi Akashi Zebrafish xenografts as a tool for in vivo studies on human cancer 124 Martina Konantz, Tugce B. Balci, Udo F. Hartwig, Graham Dellaire, Maya C. André, Jason N. Berman, and Claudia Lengerke Translational research Hematopoietic stem cell expansion: challenges and opportunities 138 Marta A. Walasek, Ronald van Os, and Gerald de Haan Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function 151 Hal E. Broxmeyer Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation 161 Lena Oevermann, Peter Lang, Tobias Feuchtinger, Michael Schumm, Heiko-Manuel Teltschik, Patrick Schlegel, and Rupert Handgretinger Current insights into neutrophil homeostasis 171 Stefanie Bugl, Stefan Wirths, Martin R. Müller, Markus P. Radsak, and Hans-Georg Kopp Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells 179 Dirk W. van Bekkum and Harald M.M. Mikkers
£99.00
John Wiley and Sons Ltd Neuroimunomodulation in Health and Disease I:
Book SynopsisThis is one of two Annals volumes that present papers by speakers at the 8th International Society for Neuroimmodulation Congress held in Dresden, Germany, October 2011. The papers focus on interactions among the immune, endocrine, and nervous systems that occur at multiple levels, from intracellular pathways by immune and neuro-endocrine mediators, to the exchange of information between the three systems that results in physiologic and adaptive effects. In certain instances, however, these interactions may be unbalanced or even disrupted, which can contribute to pathology, and aspects of such pathobiology are presented in some of the contributions. This volume focuses on the basic science of immune-neuro-endocrine interactions.Table of ContentsForeword for Neuroimmunomodulation in Health and Disease Adriana del Rey C. Jane Welsh Markus J. Schwarz Hugo O. Besedovsky vii Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes Jürgen Kraus 1 Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function Koichiro Kawashima Takeshi Fujii Yasuhiro Moriwaki Hidemi Misawa Kazuhide Horiguchi 7 T cells affect central and peripheral noradrenergic mechanisms and neurotrophin concentration in the spleen and hypothalamus Jamela Jouda Johannes Wildmann Martin Schäfer Eduardo Roggero Hugo O. Besedovsky Adriana del Rey 18 Sympathetic nerve fiber repulsion: testing norepinephrine, dopamine, and 17β-estradiol in a primary murine sympathetic neurite outgrowth assay Susanne Klatt Alexander Fassold Rainer H. Straub 26 Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network Ivan Pilipoviæ Katarina Radojeviæ Milica Perišiæ Gordana Leposaviæ 34 Presentation of neuroendocrine self in the thymus: a necessity for integrated evolution of the immune and neuroendocrine systems Vincent Geenen 42 Growth hormone modulates migration of thymocytes and peripheral T cells Wilson Savino Salete Smaniotto Daniella Arêas Mendes-da-Cruz Mireille Dardenne 49 Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction Marni N. Silverman Esther M. Sternberg 55 Hsp72, inflammation, and aging: causes, consequences, and perspectives Eduardo Ortega María Elena Bote Hugo Oscar Besedovsky Adriana del Rey 64 Regulation of intestinal morphology and GALT by pituitary hormones in the rat Luz María Cárdenas-Jaramillo Andrés Quintanar-Stephano Rosa Adriana Jarillo-Luna Víctor Rivera-Aguilar Gabriela Oliver-Aguillón Rafael Campos-Rodríguez Kalman Kovacs Istvan Berczi 72 Transforming growth factor-beta inhibits the expression of clock genes Heidemarie Gast Sonja Gordic Saskia Petrzilka Martin Lopez Andreas Müller Anton Gietl Christoph Hock Thomas Birchler Adriano Fontana 79 Role of interleukin-6 in stress, sleep, and fatigue Nicolas Rohleder Martin Aringer Matthias Boentert 88 Role of sleep in the regulation of the immune system and the pituitary hormones Beatriz Gómez-González Emilio Domínguez-Salazar Gabriela Hurtado-Alvarado Enrique Esqueda-Leon Rafael Santana-Miranda Jose Angel Rojas-Zamorano Javier Velázquez-Moctezuma 97 Erratum for Ann. N. Y. Acad. Sci. 1257: 125-132 107
£53.55
John Wiley and Sons Ltd Environmental Stressors in Biology and Medicine,
Book SynopsisThis volume stems from the Second International Conference on Environmental Stressors in Biology and Medicine, which occurred October 5-7, 2011 in Siena, Italy. Included are short reviews and perspectives on the basic mechanisms of environmental stressors; physical and chemical stressors and related diseases; air pollutants and related diseases; protection afforded by food and pharmaceuticals; and food as a source of stressors. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsOmics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions Jason P. Eiserich Jun Yang Brian M. Morrissey Bruce D. Hammock Carroll E. Cross 1 Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling Joao Laranjinha Ricardo M. Santos Cátia F. Lourenco Ana Ledo RuiM. Barbosa 10 Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis Regina Brigelius-Flohé Anna Patricia Kipp 19 Molecular medicine and the development of cancer chemopreventive agents Alberto Izzotti 26 Experimental basis for discriminating between thermal and athermal effects of water-filtered infrared A irradiation Tobias Jung Tilman Grune 33 Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease Nadia Moretto Giorgia Volpi Fiorella Pastore Fabrizio Facchinetti 39 Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown Oren Rom Sharon Kaisari Dror Aizenbud Abraham Z. Reznick 47 The link between altered cholesterol metabolism and Alzheimer's disease Paola Gamba Gabriella Testa Barbara Sottero Simona Gargiulo Giuseppe Poli Gabriella Leonarduzzi 54 Rottlerin and curcumin: a comparative analysis Emanuela Maioli Claudia Torricelli Giuseppe Valacchi 65 Plant polyphenols and human skin: friends or foes Liudmila Korkina Chiara De Luca Saveria Pastore 77 Flavonoids and metabolic syndrome Monica Galleano Valeria Calabro Paula D. Prince María C. Litterio Barbara Piotrkowski Marcela A. Vazquez-Prieto Roberto M. Miatello Patricia I. Oteiza Cesar G. Fraga 87 Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia Carmela Spagnuolo Maria Russo Stefania Bilotto Idolo Tedesco Bruna Laratta Gian Luigi Russo 95 Cigarette smoke and ozone effect on murine inflammatory responses Concetta Gardi Giuseppe Valacchi 104 Age-related changes in cellular protection, purification, and inflammation-related gene expression: role of dietary phytonutrients Angela Mastaloudis Steven M. Wood 112 The role of oxidative stress in Rett syndrome: an overview Claudio De Felice Cinzia Signorini Silvia Leoncini Alessandra Pecorelli Thierry Durand Giuseppe Valacchi Lucia Ciccoli Joussef Hayek 121 Emerging topics in cutaneous wound repair Giuseppe Valacchi Iacopo Zanardi Claudia Sticozzi Velio Bocci Valter Travagli 136 Corrigendum for Ann. N.Y. Acad. Sci. 1236: 30-43 145
£116.85
John Wiley and Sons Ltd Barriers and Channels Formed by Tight Junction
Book SynopsisTight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin). Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system NOTE: Annals volumes are available for sale as individual books or as a journal. For informatio.n on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. Table of Contents1. Perspectives on tight junction research Jörg-Dieter Schulzke, Dorothee Günzel, Lena J. John, and Michael Fromm Molecular properties of the tight junction 20. Charge-selective claudin channel Susanne M. Krug, Dorothee Günzel, Marcel P. Conrad, In-Fah M. Lee, Salah Amasheh, Michael Fromm, and Alan S. L. Yu 29. Claudin-derived peptides are internalized via specific endocytosis pathways Denise Zwanziger, Christian Staat, Anuska V. Andjelkovic, and Ingolf E. Blasig 38. A phosphorylation hotspot within the occluding C-terminal domain Max J. Dörfel and Otmar Huber 45. Determinants contributing to claudin ion channel formation Anna Veshnyakova, Susanne M. Krug, Sebastian L. Mueller, Jörg Piontek, Jonas Protze, Michael Fromm, and Gerd Krause 54. Lipolysis-stimulted lipoprotein receptor: a novel membrane protein of tricellular tight junctions Mikio Furuse, Yukako Oda, Tomohito-Higashi, Noriko Iwamoto, and Sayuri Masuda 59. Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies Jan Rossa, Dorothea Lorenz, Martina Ringling, Anna Veshnyakova, and Joerg Piontek 67. Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis Christine Rueckert, Victor Castro, Corinna Gagell, Sebastian Dabrowski, Michael Schümann, Eberhard Krause, Ingolf E. Blasig, and Reiner F. Haseloff 77. Dynamic properties of the tight junction barrier Christopher R. Weber Regulation of the tight junction and barrier function 85. Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells Takashi Kojima and Norimasa Sawada 93. The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation Michael Scharl and Gerhard Rogler 103. Caveolin binds independently to claudin-2 and occluding Christina M. Van Itallie and James M. Anderson 108. Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2 Declan F. McCole 115. Intracellular mediators of JAM-A-dependent epithelial barrier function Ana C. Monteiro and Charles A. Parkos 125. Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex Sandra Citi, Pamela Pulimeno, and Serge Paschoud 133. ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis Lorenza Gonzalez-Mariscal, Pablo Bautista, Susana Lechuga, and Miguel Quiros 142. From TER to trans- and paracellular resistance: lessons from impedance spectroscopy Dorothee Günzel, Silke S. Zakrzewski, Thomas Schmid, Maria Pangalos, John Wiedenhoeft, Corinna Blasse, Christopher Ozboda, and Susanne M. Krug Tight junctions in skin, lung, endothelia, and nervous tissues 152. Diverse type of junctions containing tight junction proteins in stratified mammalian epithelia Werner W. Franke and Ulrich-Frank Pape 158. Barriers and more: functions of tight junction proteins in the skin Nina Kirschner and Johanna M. Brandner 167. Roles for claudins in alveolar epithelial barrier function Christian E. Overgaard, Leslie A. Mitchell, and Michael Koval 175. Claudins and alveolar epithelial barrier function in the lung James A. Frank 184. Relevance of endothelial junctions in leukocyte extravasation and vascular permeability Dietmar Vestweber 193. Involvement of claudins in zebrafish brain ventricle morphogenesis Jingjing Zhang, Martin Liss, Hartwig Wolburg, Ingolf E. Blasig, and Salim Abdelilah-Seyfried 199. Modulation of tight junction proteins in the perineurium for regional pain control D. Hackel, A. Brack, M. Fromm, and K. L. Rittner
£97.85
New York Academy of Sciences Animal Models: Their Value in Predicting Drug
Book SynopsisThe Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to critically examine and discuss the traditional role of pre-clinical animal models in drug discovery, and how these models most effectively contribute to translational medicine and therapeutic development. International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
£50.50
John Wiley and Sons Ltd The Year in Evolutionary Biology 2013, Volume
Book SynopsisThe fifth installment of The Year in Evolutionary Biology series includes reviews on: gene loss, thermogenesis, and the origin of birds; sexual selection in the light of molecular evolutionary genetics; the nine-spined stickleback (Pungitius pungitius), an emerging model in evolutionary biology; the evolutionary consequences of interspecific aggression; specific-gene studies of evolution in an age of genome-wide surveying; and biodiversity and evolutionary history: expanding the PD phylogenetic diversity assessment framework. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.
£99.00
John Wiley and Sons Ltd The Year in Ecology and Conservation Biology,
Book SynopsisAs in past installments of “The Year in Ecology and Conservation Biology” series, this year’s volume contains a diverse collection of timely reviews in conservation biology and scientific, policy, and management implications, including reviews in the following areas: The Marine Mammal Protection Act at 40: Status, recovery, and future of U.S. marine mammals; translocation of imperiled species under changing climates; ecology and conservation of ginseng (Panax quinquefolius) in a changing world; risks to biodiversity from hydraulic fracturing for natural gas in the Marcellus and Utica Shales; species-area relationships and extinction forecasts; and Bounded Ranges of Variation as a framework for future conservation and fire management. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&10.1111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsRisks to biodiversity from hydraulic fracturing for natural gas in the Marcellus and Utica Shales 1 Erik Kiviat Translocation of imperiled species under changing climates 15 Mark W. Schwartz and Tara G. Martin The Marine Mammal Protection Act at 40: status, recovery, and future of U.S. marine mammals 29 Joe Roman, Irit Altman, Meagan M. Dunphy-Daly, Caitlin Campbell, Michael Jasny, and Andrew J. Read Species-area Relationships and extinction forecasts 50 John M. Halley, Vasiliki Sgardeli, and Nikolaos Monokrousos Ecology and conservation of ginseng (Panax quinquefolius) in a changing world 62 James B. McGraw, Anne E. Lubbers, Martha Van der Voort Emily H. Mooney, Mary Ann Furedi, Sara Souther, Jessica B. Turner, and Jennifer Chandler Bounded ranges of variation as a framework for a future conservation and fire management 92 Max A. Moritz, Matthew D. Hurteau, Katherine N. Suding, and Carla M. D’Antonio
£104.50
John Wiley and Sons Ltd Annals Meeting Reports - G Protein-Coupled
Book SynopsisThis Annals volume presents three scholarly meeting reports: (1) biomarkers in nutrition: new frontiers in research and application; (2) the new revolution in toxicology: The good, the bad, and the ugly; and (3) neuroprotection after cerebral ischemia. Nutritional biomarkers—biochemical, functional, or clinical indices of nutrient intake, status, or functional effects—are needed to support evidence-based clinical guidance and effective health programs and policies related to food, nutrition, and health. Such indices can reveal information about biological or physiological responses to dietary behavior or pathogenic processes, and can be used to monitor responses to therapeutic interventions and to provide information on interindividual differences in response to diet and nutrition. Many nutritional biomarkers are available; yet there has been no formal mechanism to establish consensus regarding the optimal biomarkers for particular nutrients and applications. In 2007, the United States National Academy of Sciences issued a report entitled Toxicity Testing in the 21st Century: A Vision and a Strategy. The report reviewed the state of the science and outlined a strategy for the future of toxicity testing. One of the more significant components of the vision established by the report was an emphasis on toxicity testing in human rather than animal systems. In the context of drug development, it is critical that the tools used to accomplish this strategy are maximally capable of evaluating human risk. Since 2007, many advances toward implementation of this vision have been achieved, particularly with regard to safety assessment of new chemical entities intended for pharmaceutical use. Cerebral ischemia, a focal or global insufficiency of blood flow to the brain, can arise through multiple mechanisms, including thrombosis and arterial hemorrhage. Ischemia is a major driver of stroke, one of the leading causes of morbidity and mortality worldwide. While the general etiology of cerebral ischemia and stroke has been known for some time, the conditions have only recently been considered treatable. This report describes current research in this field seeking to fully understand the pathomechanisms underlying stroke; to characterize the brain's intrinsic injury, survival, and repair mechanisms; to identify putative drug targets as well as cell-based therapies; and to optimize the delivery of therapeutic agents to the damaged cerebral tissue. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of Contents1 Application of combined omics platforms to accelerate biomedical discovery in diabesityIrwin J. Kurland, Domenico Accili, Charles Burant, Steven M. Fischer, Barbara B. Kahn, Christopher B. Newgard, Suma Ramagiri, Gabriele V. Ronnett, john A. Ryals, Mark Sanders, Joe Shambaugh, John Shockcor, and Steven S. Gross 17 Prioritizing health disparities in medical education to improve careTemitope Awosogba, Joseph R. Betancourt, F. Garrett Conyers, Estela S. Estape, Fritz Francois, Sabrina J. Gard, Arthur Kaufman, Mitchell R. Lunn, Marc A. Nivet, Joel D. Oppenheim, Claire Pomeroy, and Howa Yeung 31 The paradox of overnutrition in aging and cognitionRoger A. Fielding, John Gunstad, Deborah R. Gustafson, Steven B. Heymsfield, John G. Kral, Lenore J. Launer, Josef Penninger, David I. W. Philips, and Nikolaos Scarmeas 45 Vitamin D: beyond boneSylvia Christakos, Martin Hewison, David G. Gardner, Carol L. Wagner, Igor N. Sergeev, Erica Rutten, Anastassios G. Pittas, Ricardo Boland, Luigi Ferrucci, and Daniel D. Bikle
£57.56
John Wiley and Sons Ltd The Renaissance of Cancer Immunotherapy: The 7th
Book SynopsisThis Annals volume includes invited short reviews on topics presented at the 7th International Cancer Vaccine Symposium “Renaissance of Cancer Immunotherapy”, held September 9-11, 2012 in Florence, Italy. The papers cover the latest progress in basic immunology research and its translation to cancer patients. The meeting and papers pay tribute to the successes in the last few years that have led to the approval of new immunotherapies and the awarding of the Nobel Prize in medicine to three immunologists. The symposium is dedicated to one of these recipients, Dr. Ralph Steinman who discovered dendritic cells, immune cells that are vital in immune responses and immunotherapies for cancer. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.Table of ContentsIntroduction to The Renaissance of Cancer Immunotherapy vOlivera J. Finn and Gerold Schuler Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy 1Matthews D. Vesely and Robert D. Schreiber Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells 6Maurizio Zanetti Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance 12Bridget Keenan and Elizabeth M. Jaffee Integration of epidemiology, immunobiology, and translational research for brain tumors 17Hideho Okada, Michael E. Scheurer, Saumendra N. Sarkar, and Melissa L. Bondy Human dendritic cells subsets as targets and vectors for therapy 24Eynav Klechevsky and Jacques Banchereau Dendritic cell immunotherapy 31Rachel Lubong Sabado and Nina BhardwajMolecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance 46Dylan J. Johnson and Pamela S. Ohashi Preventing cancer by targeting abnormally expressed self-antigens: MUC1 vaccines for prevention of epithelial adenocarcinomas 52Pamela L. Beatty and Olivera J. Finn Immunological control of cell cycle aberrations for avoidance of oncogenesis: the case of tetraploidy 57Laura Senovilla, Lorenzo Galluzzi, Maria Castedo, and Guido Kroemer Ongoing adaptive immune responses in the microenvironment of melanoma metastases 62Nicolas van Baren and Pierre G. Coulie Main features of human T helper 17 cells 66Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi, and Sergio Romagnani In silico modeling of cancel cell dissemination and metastasis 71Lu-En Wai, Vipin Narang, Alexandre Gouaillard, Lai Guan Ng, and Jean-Pierre Abastado Common pathways to tumor rejection 75Ena Wang, Davide Bedognetti, Sara Tomei, and Francesco M. Marincola Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy 80Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto. Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa, and Naoshi Kawamura
£99.00
John Wiley and Sons Ltd Evolutionary Dynamics and Information Hierarchies
Book SynopsisEvolutionary Dynamics and Information Hierarchies in Biological Systems: Aspen Center for Physics Workshop. Organisms use a variety of mechanisms to store, interpret, and use information that is organized in a large and complex hierarchy from DNA sequences, to chromatin regulation, to intra/extracellular signaling, to tissue/organ organization, to the interactions between organisms and species. This Annals volume presents individual papers and a summarizing meeting report stemming from a workshop at the Aspen Center for Physics in Aspen, Colorado, organized to discuss these issues. The three themed weeks of the workshop focused on the organization of DNA into chromatin, epigenetic adaptation and host/pathogen interaction, and macroevolution. Although these areas represent a wide breadth of biological phenomena, several unifying themes emerged through workshop discussions. In particular, the differences between the simplicity of our theoretical models and the complex interactions characteristic of real physical systems were repeatedly highlighted. Workshop discussions therefore pointed to key areas where theory and observations should aim to converge as we refine our understanding of evolution.
£99.00
John Wiley and Sons Ltd Blavatnik Awards for Young Scientists 2012,
Book SynopsisThis volume comprises contributions from faculty and postdoctoral finalists of the 2012 New York Academy of Science Blavatnik Awards for Young Scientists. The Awards recognize highly innovative, multidisciplinary accomplishments in the life sciences, physical sciences, mathematics, and engineering. Included in this volume are manuscripts of the individual finalists’ areas of research, which provide a glimpse of some of today’s most compelling scholarly work. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.
£99.00
John Wiley and Sons Ltd Cost Estimates for Flood Resilience and
Book SynopsisIn the aftermaths of Hurricanes Irene, in 2011, and Sandy, in 2012, New York City has come to recognize the critical need to better prepare for future storm surges and to anticipate future trends, such as climate change and socioeconomic developments. This Annals volume presents research that assesses the costs of six different flood management strategies to anticipate long-term challenges the City will face. The proposed strategies vary from increasing resilience by upgrading building codes and introducing small scale protection measures, to creating green infrastructure asbuffer zones and large protective engineering works such as storm surge barriers. The initial investment costs of alternative strategies vary between $11.6 and $23.8 bn, maximally. This report shows that a hybrid solution, combining protection of critical infrastructure and resilience measures that can be upgraded over time, is less expensive. However, with increasing risk in the future, storm surge barriers may become cost-effective, as they can provide protection to the largest areas in both New York and New Jersey.
£104.50
John Wiley and Sons Ltd Annals Meeting Reports - Omics Platforms,
Book SynopsisThis Annals volume presents four scholarly meeting reports: (1) Application of combined omics platforms to accelerate biomedical discovery in diabesity; (2) Prioritizing health disparities in medical education to improve care; (3) The paradox of overnutrition in aging and cognition; and vitamin D: beyond bone. Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not universally predictive. Defining the metabolic characteristics of obesity that lead to diabetes, and how obese individuals who develop diabetes different from those who do not, are important goals. The use of large-scale omics analyses (e.g., metabolomic, proteomic, transcriptomic, and lipidomic) of diabetes and obesity may help to identify new targets to treat these conditions. This report discusses how various types of omics data can be integrated to shed light on the changes in metabolism that occur in obesity and diabetes. Despite yearly advances in life-saving and preventive medicine, as well as strategic approaches by governmental and social agencies and groups, significant disparities remain in health, health quality, and access to health care within the United States. The determinants of these disparities include baseline health status, race and ethnicity, culture, gender identity and expression, socioeconomic status, region or geography, sexual orientation, and age. In order to renew the commitment of the medical community to address health disparities, particularly at the medical school level, we must remind ourselves of the roles of doctors and medical schools as the gatekeepers and the value setters for medicine. Within those roles are responsibilities toward the social mission of working to eliminate health disparities. This effort will require partnerships with communities as well as with academic centers to actively develop and to implement diversity and inclusion strategies. Besides improving the diversity of trainees in the pipeline, access to health care can be improved, and awareness can be raised regarding population-based health inequalities. Populations of many countries are becoming increasingly overweight and obese, driven largely by excessive calorie intake and reduced physical activity; greater body mass is accompanied by epidemic levels of comorbid metabolic diseases. At the same time, individuals are living longer. The combination of aging and the increased prevalence of metabolic disease is associated with increases in aging-related comorbid diseases such as Alzheimer's disease, cerebrovascular dementia, and sarcopenia. Here, correlative and causal links between diseases of overnutrition and diseases of aging and cognition are explored. In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. However, the biological significance of the expression of the VDR in different tissues is not fully understood, and the role of vitamin D in extraskeletal health has been a matter of debate. This report summarizes recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of Contents1 Application of combined omics platforms to accelerate biomedical discovery in diabesityIrwin J. Kurland, Domenico Accili, Charles Burant, Steven M. Fischer, Barbara B. Kahn, Christopher B. Newgard, Suma Ramagiri, Gabriele V. Ronnett, john A. Ryals, Mark Sanders, Joe Shambaugh, John Shockcor, and Steven S. Gross 17 Prioritizing health disparities in medical education to improve careTemitope Awosogba, Joseph R. Betancourt, F. Garrett Conyers, Estela S. Estape, Fritz Francois, Sabrina J. Gard, Arthur Kaufman, Mitchell R. Lunn, Marc A. Nivet, Joel D. Oppenheim, Claire Pomeroy, and Howa Yeung 31 The paradox of overnutrition in aging and cognitionRoger A. Fielding, John Gunstad, Deborah R. Gustafson, Steven B. Heymsfield, John G. Kral, Lenore J. Launer, Josef Penninger, David I. W. Philips, and Nikolaos Scarmeas 45 Vitamin D: beyond boneSylvia Christakos, Martin Hewison, David G. Gardner, Carol L. Wagner, Igor N. Sergeev, Erica Rutten, Anastassios G. Pittas, Ricardo Boland, Luigi Ferrucci, and Daniel D. Bikle
£57.56
Prometheus Books Dirty Virtues: The Emergence of Ecological Virtue
Book SynopsisThis is the first extensive study of ecological virtue ethics and the new rhetoric of environmentalists. Based on a wide-ranging survey of environmental literature, Louke van Wensveen offers an overview of current "green" virtue language and proposes the basic elements of a matching ecological virtue theory, dubbed "dirty virtues" by ecological philosophers. Environmental ethics is not exhausted by debates about the need to preserve rivers, our duties to bioregions, and the intrinsic value of nonhuman nature; rather, ecoliterature also contains a rich virtue language. Highlighting the integrity, diversity, internal tensions, dynamism, and visionary character of this ecological virtue language, the author shows both its historical roots and innovative features. Van Wensveen illustrates a widespread awareness of attitudes and habits that help or harm our relations with the nonhuman world. She includes a unique catalog of 189 virtues and 174 vices that mark the vision and praxis of people committed to ecological flourishing. The second part of Dirty Virtues presents carefully crafted criteria to help discern genuine virtue and vice in an ecological age. Her arguments are distinguished by a critical balance of moral sources, including Aristotelian virtue theory, Christian tradition, women's experiences, psychological theory, and metaphorical representations of nonhuman nature. Methodologically innovative and boldly interdisciplinary, Dirty Virtues will challenge and inspire virtue theorists, as well as environmental ethicists and theologians.
£48.60
Taylor & Francis Inc Biochips as Pathways to Drug Discovery
Book SynopsisIn the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as biochips to reduce the cost of drug discovery and improve drug safety. The book explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes.The authors provide an in-depth review of the clinical and pharmacogenomic relevance of biochips, ChIP-chip assays, and high-throughput approaches. They discuss how biochips are used to develop biomarkers in the drug discovery process, primarily for gene expression profiling and Single Nucleotide Polymorphism (SNP) analysis. The book includes coverage of experimental theory, quality control, clinical laboratory sampling considerations, database concepts, industrial laboratory design, and the analysis of the resultant large data sets. It discusses the application of biochips to the study of malaria, toxicogenomics, and SNPs, as well as intellectual property and market overviews. The book concludes with a comprehensive overview of how these chips are employed from early target discovery through preclinical toxicology and on through to pharmacogenomic and proof of concept studies in humans. Written in an easily accessible style, the breadth of coverage introduces the subject to those new to the field, while the depth of coverage forms a foundation for future work. The book gives you the knowledge required to leverage the technology into bona fide discoveries. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.Trade Review“The authors of this volume provide an in-depth review of the clinical and pharmacogenomic relevance of biochips, ChIP-chip assays, and high-throughput approaches. … The book includes coverage of experimental theory, quality control, clinical laboratory sampling considerations, database concepts, industrial laboratory design, and the analysis of the resultant large data sets. … Written in an easily accessible style, the breadth of coverage introduces the subject to those new to the field, while the depth of coverage forms a foundation for future work.” — In Anticancer Research, Vol. 27, No. 3B, May/June 2007"This book is a must have for students who use biochips in their graduate work or others initiating efforts in these areas . . . In summary, Biochips as Pathways to Drug Discovery provides a broad yet detailed look at the use of DNA microarrays in drug discovery." – Matthew D. Disney, The University at Buffalo, The State University of New York, in ChemMedChem, 2008, No. 3Table of ContentsDNA Biochips — Past, Present, and Future: An Overview. Three-Dimensional HydroArrays: Novel Microarrays for Genomic and Proteomic Studies. Biochip in Malaria for Antiparasitic Discovery. Regional Variations in Intestinal ATP-Binding Cassette Transporter Expression Identified with a Global Error Assessment Model. Toxicogenomics in Drug Safety Evaluation: Bridging Drug Discovery and Development. The Next Generation of Automated Microarray Platforms for a Multiplexed CYP2D6 Assay. Biopsy and RNA Extraction Procedures of Muscle and Adipose Tissue for Microarray Gene-Expression Profiling. ChIP-on-Chip: Analysis of Genomewide Protein Binding and Posttranslational Modifications. DNA Microarrays as Functional Genomics Tools for Cancer Drug Discovery. High-Throughput Microarray Analysis. Laboratory Automation: Strategies for High-Volume Industrial Microarray Programs. Association Studies: Practical and Theoretical Considerations for Drug Discovery, Evaluation, and Beyond. Approaches for Microarray Data Validation. Microarray Enterprise Information Management: What Is It and Why Is It Important? Quality Control of Microarray Data. Microarray Data Normalization and Transformation. Amplification Strategies and DNA Biochips. Ribo-SPIA™, a Rapid Isothermal RNA Amplification Method for Gene Expression Analysis. Genomics, Transcriptomics, and Proteomics: Novel Detection Technologies and Drug Discovery. Intellectual Property Issues for DNA Chips and Microarrays. Biochips: Market Drivers and Commercial Prospect. A Pharmaceutical Perspective for Microarrays and Biochips: Current-Market Overview and Future Trends.
£54.14
Learning Express Llc AP Biology Flash Review
Book SynopsisThis handy pocket guide is the ideal on-the-go study system for the AP Biology Exam. Inside, students will find definitions and explanations for the 600 most-tested terms and concepts tested on the exam. Studying the key terms in this book is an essential step towards mastering the exam and enjoying all the advantages of test success
£10.92
Taylor & Francis Inc Feeding and Digestive Functions in Fishes
Book SynopsisUnderstanding the biology of the innumerable number of aquatic species on our planet is the focus of sustained research efforts. Environmental degradation, management or rehabilitation of wild stocks, and the forecasted climatic changes are fueling interest in the study of the ecology, feeding behavior, and nutrition of aquatic animals in their natural habitat. In parallel, the rapid expansion of aquaculture in many parts of the world has supported vigorous research programs on nutrition, and feeding of cultivated aquatic organisms. More than 250 aquatic species are cultivated on a commercial scale using a wide variety of production systems. This great diversity results in great opportunities and tremendous challenges. Topics covered in this book are as diverse as, feeding ecology of fish in their natural habitat, feeding behavior, digestive anatomy, biochemistry and physiology of different fish species at different life stages, the impact of diet on gastro-intestinal development and health, nutrition and disease resistance, and modeling conversion of food or feed inputs into biomass.Table of ContentsFeeding Ecology of Fishes in the Brazilian AmazonA Naturalistic Approach; Environmental Changes, Habitat Modifications and Feeding Ecology of Freshwater Fish; Feeding Activity in Teleost Fish: Influence of Biotic and Abiotic Factors; Classical and Modern Concepts in Fish Digestion; Temperature Adaptation of Digestive Enzymes in Fish; Diets, Physiology, Biochemistry and Digestive Tract Development of Freshwater Fish Larvae; Ontogeny and Physiology of the Digestive System of Marine Fish Larvae; Tracer Studies in Fish Larvae; An Overview of the Feeding Ecology and Physiology of Elasmobranch Fishes; Alternative Protein Sources and Digestive Function Alterations in Teleost Fishes; Nutrition and Disease Resistance in Fish; Efficiency of Conversion of Feed Inputs into Animal Biomass: The Usefulness of Bioenergetics Models and Need for a Transition to Nutrient-flow Models
£171.00
Taylor & Francis Inc Tomatoes and Tomato Products: Nutritional,
Book SynopsisThe contributors to this book are authors of international and national standing, leaders in the field and trendsetters. The book covers emerging fields of science and important discoveries relating to tomatoes and related products. This represents a one-stop shopping of material related to tomatoes. This book will be essential reading for plant scientists, nutritionists, dieticians, pharmacologists, health care professionals and research scientists.Table of ContentsPart 1: Characterization and Composition of Tomato Plant and Fruit: Tomato: Origin, Cultivation Techniques and Germplasm Resources; Cultivar and Agricultural Management on Lycopene and Vitamin C Contents in Tomato Fruits; Field Trials of Genetically Modified Tomato: Fruit Quality and Productivity; Post-harvest Ripening of Tomato; Tomato and Flavour; Antioxidant Activity in Tomato: A Function of Genotype; Carotenoids in Tomato Plants; Tomato Lectin; Presence of Zingiberene and Curcumene in Wild Tomato Leaves; The Role of Intracellular and Secreted Purple Acid Phosphatases in Tomato Phosphate Nutrition; Nutritional Characterization of Tomato Juices; Acrylamide in Tomato ProductsPart 2: Cellular and Metabolic Effects of Tomato and Related Products or Components: Tomato Leaf Crude Extracts for Insects and Spider Mite Control; Bioactive Polysaccharides from Tomato; Ingestion of Tomato Products and Lycopene Isomers in Plasma; Comparative Studies of Antioxidant Compounds in Different Tomato Cultivars; Antioxidant Activity of Fresh-cut Tomatoes: Effects of Minimal Processing and Maturity Stage at Harvest; Tomato and Anticancer Properties of Saliva; DNA Strand Breaks and Tomatoes; Tomato Carotenoids and the IGF System in Cancer; Consumption of Tomato Paste and Benign Prostate Hyperplasia; Tomatoes and Components as Modulators of Experimental Prostate Carcinogenesis; Tomato Juice, Prostate Cancer and Adenosine Deaminase Enzyme; Effect of Tomato Juice on Prevention and Management of Lung Diseases: Cigarette Smoke-induced Emphysema in the Senescence-accelerated Mouse and Bronchial Asthma in HumanPart 3: Analysis and Methods: Proteomics of Tomato Seed and Pollen; Gene Transfer in Tomato and Detection of Transgenic Tomato Products; Assaying Vitamins and Micronutrients in Tomato; Methods for PCR and Gene Expression Studies in Tomato Plants; DNA Analysis of Tomato Seeds in Forensic Evidence
£171.00
Wolfram Media Inc A New Kind of Science
Book Synopsis
£36.00
Dissertation.com Is an Objective Measuring System for Facial Attractiveness Possible?
£33.88
Taylor & Francis Inc Introduction to Statistical Methods for Clinical
Book SynopsisClinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial.After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.Trade Review… There is much good material in this book. The individual chapters are well written and cover the technical aspects as well. A major strength is the ordering of topics to follow the thought process used in the development and implementation of a protocol from defining the question to reporting results. There are careful discussions on fundamental principles and the pivotal role played by statistics is well brought out. … there is much that practicing pharmaceutical statisticians will find useful in this book. They will find the coverage of fundamental principles useful and the technical content of the book a good reference source. …—Pharmaceutical Statistics, 2010… fits the need for a contemporary text and handbook that is oriented toward the clinical trial statistician. I highly recommend it and look forward to using it as both a primary and supplemental text in our curriculum, as well as a research resource.—James J. Dignam, University of Chicago, JASA, March 2009The (technical) statistical content is the main focus of the book and this is what helps it to stand apart from most others on clinical trials (even the more obviously statistically orientated ones). It takes the reader to quite a technical background that would serve him or her well if moving on to research problems in the various areas covered, yet does not lose sight of practical issues. … For those of us with the interest (and need) to grapple with these more statistical issues, I wholeheartedly recommend it.—Biometrics, December 2008…The book is very well written and clear. … the authors generally strike the right balance for the intended audience. The inclusion of many historically important as well as contemporary examples to illustrate various points throughout the text is a major strength, as is the inclusion of several modern topics not seen in other texts. As a basis for a course in clinical trials for graduate students in biostatistics, this book is outstanding. In addition, statisticians in the pharmaceutical industry, government, or academia … will find this text extremely informative and useful.” —Michael P. McDermott, University of Rochester Medical Center, Journal of Biopharmaceutical Statistics, 2008Table of ContentsPreface. Introduction to Clinical Trials. Defining the Question. Study Design. Sample Size. Randomization. Data Collection and Quality Control. Survival Analysis. Longitudinal Data. Quality of Life. Data Monitoring and Interim Analysis. Selected Issues in the Analysis. Closeout and Reporting. Special Topics. Appendix. References. Index.
£80.74
Taylor & Francis Inc Handbook of Exponential and Related Distributions
Book SynopsisThe normal distribution is widely known and used by scientists and engineers. However, there are many cases when the normal distribution is not appropriate, due to the data being skewed. Rather than leaving you to search through journal articles, advanced theoretical monographs, or introductory texts for alternative distributions, the Handbook of Exponential and Related Distributions for Engineers and Scientists provides a concise, carefully selected presentation of the properties and principles of selected distributions that are most useful for application in the sciences and engineering.The book begins with all the basic mathematical and statistical background necessary to select the correct distribution to model real-world data sets. This includes inference, decision theory, and computational aspects including the popular Bootstrap method. The authors then examine four skewed distributions in detail: exponential, gamma, Weibull, and extreme value. For each one, they discuss general properties and applicability to example data sets, theoretical characterization, estimation of parameters and related inferences, and goodness of fit tests. The final chapter deals with system reliability for series and parallel systems.Presenting methods based on statistical simulations and numerical computations, the Handbook of Exponential and Related Distributions for Engineers and Scientists supplies hands-on tools for applied researchers in need of practical tools for data analysis.Table of ContentsGENERAL STATISTICAL THEORY. Basic Concepts. Some Common Probability Distributions. Concepts of Statistical Inference. Elements of Decision Theory. Computational Aspects. EXPONENTIAL AND OTHER POSITIVELY SKEWED DISTRIBUTIONS WITH APPLICATIONS. Exponential Distribution. Gamma Distribution. Weibull Distribution. Extreme Value Distributions. System Reliability. Bibliography. Selected Statistical Tables. Index.
£142.50
Taylor & Francis Inc Spatial Cluster Modelling
Book SynopsisResearch has generated a number of advances in methods for spatial cluster modelling in recent years, particularly in the area of Bayesian cluster modelling. Along with these advances has come an explosion of interest in the potential applications of this work, especially in epidemiology and genome research. In one integrated volume, this book reviews the state-of-the-art in spatial clustering and spatial cluster modelling, bringing together research and applications previously scattered throughout the literature. It begins with an overview of the field, then presents a series of chapters that illuminate the nature and purpose of cluster modelling within different application areas, including astrophysics, epidemiology, ecology, and imaging. The focus then shifts to methods, with discussions on point and object process modelling, perfect sampling of cluster processes, partitioning in space and space-time, spatial and spatio-temporal process modelling, nonparametric methods for clustering, and spatio-temporal cluster modelling. Many figures, some in full color, complement the text, and a single section of references cited makes it easy to locate source material. Leading specialists in the field of cluster modelling authored each chapter, and an introduction by the editors to each chapter provides a cohesion not typically found in contributed works. Spatial Cluster Modelling thus offers a singular opportunity to explore this exciting new field, understand its techniques, and apply them in your own research.Trade Review"This text provides an effective treatment and review of several ways to view a clustering pattern, depending on the context. Examples include image segmentation, spatial epidemiology, and object recognition using partition models. … Each of the 14 chapters has multiple authors, each aware of the book's content so there is effective cross-referencing. I strongly recommend this book for anybody who is serious about spatial clustering. …"-Tom Burr Statistics in Medicine, Vol. 23, 2004 "[This book] is a collection of contributions by leading specialist in the field, which are brought together coherently with unified notation. … Overall, the book is an excellent, well and up-to-date referenced presentation of the current state of research in spatial cluster analysis … an insightful reference not only for the statistician, but also for scientists … ."-Zentralblatt MATH, 1046 "The chapter authors are all recognized for their excellence in research. … the text is well written and informative, and is a worthy addition to the library of anyone wishing to keep up to date on current research in spatial cluster modeling."-Journal of the American Statistical Association, Vol. 99, No. 467, September 2004Table of ContentsSpatial Cluster Modelling: An Overview. POINT PROCESS CLUSTER MODELLING: Significance in Scale-Space for Clustering. Statistical Inference for Cox Processes. Extrapolating and Interpolating Spatial Patterns. Perfect Sampling for Point Process Cluster Modelling. Bayesian Estimation and Segmentation of Spatial Point Processes Using Voronoi Tilings. SPATIAL PROCESS CLUSTER MODELLING: Partition Modelling. Cluster Modelling for Disease Rate Mapping. Analyzing Spatial Data Using Skew-Gaussian Processes. Accounting for Absorption Lines In Images Obtained With The Chandra X-Ray Observatory. Spatial Modelling of Count Data: A Case Study in Modelling Breeding Bird Survey Data on Large Spatial Domains. SPATIO-TEMPORAL CLUSTER MODELLING: Modelling Strategies for Spatial-Temporal Data. Spatio-Temporal Partition Modelling: An Example FROM Neurophysiology. Spatio-Temporal Cluster Modelling of Small Area Health Data. References. Index. Author Index.
£142.50
Taylor & Francis Inc Knowledge Discovery in Proteomics
Book SynopsisMulti-modal representations, the lack of complete and consistent domain theories, rapid evolution of domain knowledge, high dimensionality, and large amounts of missing information - these are challenges inherent in modern proteomics. As our understanding of protein structure and function becomes ever more complicated, we have reached a point where the actual management of data is a major stumbling block to the interpretation of results from proteomic platforms, to knowledge discovery. Knowledge Discovery in Proteomics presents timely, authoritative discussions on some of the key issues in high-throughput proteomics, exploring examples that represent some of the major challenges of knowledge discovery in the field. The authors focus on five specific domains:Mass spectrometry-based protein analysis Protein-protein interaction network analysis Systematic high-throughput protein crystallization Systematic, integrated analysis of multiple data repositories Systems biologyIn each area, the authors describe the challenges created by the type of data produced and present potential solutions to the problem of data mining within the domain. They take a systems approach, covering individual data and integrating its computational aspects, from data preprocessing, storage, and access to analysis, visualization, and interpretation.With clear exposition, practical examples, and rich illustrations, this book presents an outstanding overview of this emerging field, and builds the background needed for the fruitful exchange of ideas between computational and biological scientists.Table of ContentsIntroduction. Knowledge Management. Current Status and Future Perspectives of Mass Spectrometry. Graph Theory Analysis of Protein--Protein Interactions. HTP Protein Crystallization Approaches. Integration of Diverse Data, Algorithms, and Domains. From High-Throughput to Systems Biology. References.
£123.50
Taylor & Francis Inc Meta-analysis of Binary Data Using Profile
Book SynopsisProviding reliable information on an intervention effect, meta-analysis is a powerful statistical tool for analyzing and combining results from individual studies. Meta-Analysis of Binary Data Using Profile Likelihood focuses on the analysis and modeling of a meta-analysis with individually pooled data (MAIPD). It presents a unifying approach to modeling a treatment effect in a meta-analysis of clinical trials with binary outcomes.After illustrating the meta-analytic situation of an MAIPD with several examples, the authors introduce the profile likelihood model and extend it to cope with unobserved heterogeneity. They describe elements of log-linear modeling, ways for finding the profile maximum likelihood estimator, and alternative approaches to the profile likelihood method. The authors also discuss how to model covariate information and unobserved heterogeneity simultaneously and use the profile likelihood method to estimate odds ratios. The final chapters look at quantifying heterogeneity in an MAIPD and show how meta-analysis can be applied to the surveillance of scrapie. Containing new developments not available in the current literature, along with easy-to-follow inferences and algorithms, this book enables clinicians to efficiently analyze MAIPDs.Trade Review"The book is very focused on the methods the authors have developed for meta-analysis. It includes a lot of technical details for solving likelihood equations. The advanced key method is based on nonparametric mixing distributions and the question how many mixing components do we have is the crucial one. ... A positive aspect is the development of the software tool. The software CAMAP can be downloaded with no costs from the website: http://www.personal.rdg.ac.uk/~sns05dab/Software.html ..." -ISCB News #49, June 2010 "The authors have succeeded in demonstrating recent developments and the utility of statistical tools for MAIPD-type meta-analysis. ... a strong background in mathematics is not needed. The material that is covered in this book can be a part of an advanced biostatistics course. The book should be accessible and useful to graduate students in biostatistics and biostatisticians working in theory as well as in applied areas. The book is well worth recommending for purchase by a library." -Journal of the Royal Statistical Society, Series A, 2010, 173 "I enjoyed reading this book. Having worked with commonly used tools of meta-analysis, I learned a new set of tools and options. The writing is clear and easy to follow. ... this is a good book that assumes only a basic knowledge of metaanalysis. Students new to the subject should find it easy to follow while old hands will find interesting new research areas. I would recommend it to anyone interested in the field." -Rafael Perera, Journal of the American Statistical Association, June 2010 "I recommend the book as a supplement for a graduate-level course in meta-analysis and for readers seeking an alternative approach to analyze MAIPD or multicenter clinical trial studies, specifically when the outcome variable is the occurrence of rare events." -Taye H. Hamza, Statistics in Medicine, 2009 "The text contains many real-world examples which add to the usefulness of the book. ... The balance between statistical theory and practical applications with CAMAP make the text suitable for private study and research." -C.M. O'Brien, International Statistical Review, 2009 "I am not aware of a more complete source for this topic. The authors' presentation of the core ideas behind the derivation and use of PML estimates is accessible to anyone familiar with standard likelihood-based estimation. The many good examples facilitate intelligent application of these ideas, and the described software makes implementation simple." -Eloise Kaizar, Biometrics, June 2009Table of ContentsIntroduction. The Basic Model. Modeling Unobserved Heterogeneity. Modeling Covariate Information. Alternative Approaches. Incorporating Covariate Information and Unobserved Heterogeneity. Working with CAMAP. Estimation of Odds Ratio Using the Profile Likelihood. Quantification of Heterogeneity in an MAIPD. Scrapie in Europe: A Multicountry Surveillance Study as an MAIPD. Appendix. Bibliography. Index.
£142.50
Taylor & Francis Inc Longitudinal Data Analysis
Book SynopsisAlthough many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory and applications. It also focuses on the assorted challenges that arise in analyzing longitudinal data.After discussing historical aspects, leading researchers explore four broad themes: parametric modeling, nonparametric and semiparametric methods, joint models, and incomplete data. Each of these sections begins with an introductory chapter that provides useful background material and a broad outline to set the stage for subsequent chapters. Rather than focus on a narrowly defined topic, chapters integrate important research discussions from the statistical literature. They seamlessly blend theory with applications and include examples and case studies from various disciplines. Destined to become a landmark publication in the field, this carefully edited collection emphasizes statistical models and methods likely to endure in the future. Whether involved in the development of statistical methodology or the analysis of longitudinal data, readers will gain new perspectives on the field.Trade ReviewThe scope is remarkable, and the degree of integration and polish is admirable. The contributors include many of the most innovative researchers in the field, and happily, many of the clearest writers as well. … a lively text with clear-eyed positions and well-argued recommendations on how to analyze data of specific structures. … [material] is all accessible, well explained, and well illustrated using examples … a very good book … an excellent resource for a graduate class for statisticians or biostatisticians, and as a reference for quantitatively minded researchers.—Statistics in Medicine, 2011The volume’s editors have assembled a world-class panel of contributors; many have made seminal contributions to the field (this includes the editors themselves). Immediately apparent is the uniformity of notation and writing style not typically found in volumes of this kind. The editors clearly have taken great care to ensure a whole document rather than a disjointed patchwork typical of similar collections. Chapters reflect contributor diversity while suppressing distracting idiosyncrasies. … Experienced researchers and those new to the field will find useful material here. … several chapters provide fresh insights. For graduate students and new researchers, the book provides a useful introduction and comprehensive reference material for the topics it covers. Case studies and software enable readers to implement some methods described in the book, with supplemental datasets and programs appearing on a useful website. … A strong inaugural volume for Chapman & Hall’s new series on modern statistical methods, Longitudinal Data Analysis provides an outstanding model for future entries.—Biometrics, September 2010… Longitudinal Data Analysis is the first book to collect and sort through many of the most important developments. The authors make clear the assumptions of the statistical methods and their consequences. Coupled with an abundance of examples, the book guides the practitioner about when to apply one method as opposed to another. The book has remarkable breadth and contains material that would likely be new even to those that analyze longitudinal data on a regular basis. Longitudinal Data Analysis would be useful for applied statisticians looking to expand their analytical toolkit and statistical researchers familiar with the area but looking for a good reference. …an excellent text for a special topics course for Ph.D. students in statistics. It has a good balance of statistical theory and applications, with a large number of real data examples and case studies to illustrate how to use the methods described therein. …a well organized, excellent overview of the state of the art in modeling longitudinal data and would make a useful supplement to the library of anyone that analyzes this type of data.—Journal of the American Statistical Association, June 2010…a concise but complete encyclopedia on longitudinal data analysis. The editors have made a great effort to produce a volume providing a comprehensive and up-to-date view of the theory and application of longitudinal data analysis. … One of the strengths of the book is the organizational structure and the fact that the book has been written by well-known experts in the field. … I find this book very useful for statisticians and researchers in many fields where the interest relies on studying the change of an outcome or multiple outcomes over time. Many of the chapters include examples and case studies in different disciplines and some of this material can be found in the website of this book (http://www.biostat.harvard.edu/ fitzmaur/lda). I would like to congratulate the editors and all the contributing authors for preparing this comprehensive handbook on many interesting and complementary aspects of the theory and applications of longitudinal data analysis. This handbook will have, without any doubt, an important place on the shelf of those statisticians and applied researchers working with longitudinal data.—Journal of Applied Statistics, Vo. 36, No. 10, October 2009This is public-service broadcasting at its best. Many of the leading internationally recognized experts in the field have been assembled to write a series of expository articles on an important area of modern statistics. … Care has clearly been taken to make the book hang together—it’s not like some ‘edited tomes’ consisting of a set of papers stapled together. There is a mixture of theory and applications with real data, some of which is available on a website. In my opinion the book will be a must-have for anyone seriously involved with repeated measures or longitudinal data.—International Statistical Review, 2009Other longitudinal data books do not have the breadth of this one. … I highly recommend this book to anyone interested in learning about modern methods for longitudinal data analysis. I think it would make a particularly good book for a Ph.D.-level reading course or as a supplement to a longitudinal data textbook in a graduate-level course. I especially recommend this book to statistical researchers, as it makes a great reference book.—Journal of Biopharmaceutical Statistics, Issue 4, 2009Table of ContentsIntroduction and Historical Overview. Parametric Modeling of Longitudinal Data. Nonparametric and Semiparametric Methods for Longitudinal Data. Joint Models for Longitudinal Data. Incomplete Data. Index.
£130.00
Taylor & Francis Inc Kinetic Modelling in Systems Biology
Book SynopsisWith more and more interest in how components of biological systems interact, it is important to understand the various aspects of systems biology. Kinetic Modelling in Systems Biology focuses on one of the main pillars in the future development of systems biology. It explores both the methods and applications of kinetic modeling in this emerging field.The book introduces the basic biological cellular network concepts in the context of cellular functioning, explains the main aspects of the Edinburgh Pathway Editor (EPE) software package, and discusses the process of constructing and verifying kinetic models. It presents the features, user interface, and examples of DBSolve as well as the principles of modeling individual enzymes and transporters. The authors describe how to construct kinetic models of intracellular systems on the basis of models of individual enzymes. They also illustrate how to apply the principles of kinetic modeling to collect all available information on the energy metabolism of whole organelles, construct a kinetic model, and predict the response of the organelle to changes in external conditions. The final chapter focuses on applications of kinetic modeling in biotechnology and biomedicine.Encouraging readers to think about future challenges, this book will help them understand the kinetic modeling approach and how to apply it to solve real-life problems.Downloadable Resources FeaturesExtensively used throughout the text for pathway visualization and illustration, the EPE software is available on the accompanying downloadable resources. The downloadable resources also include pathway diagrams in several graphical formats, DBSolve installation with examples, and all models from the book with dynamic visualization of simulation results, allowing readers to perform in silico simulations and use the models as templates for further applications.Trade Review…This book will help the reader to understand the kinetic modeling approach, apply it to solve real-life problems, and give the opportunity to think about future challenges. It also illustrates how to apply the principles of kinetic modeling to perform various functions. …—ISCB News #49, June 2010Table of ContentsIntroduction. Systems Biology, Biological Knowledge, and Kinetic Modelling. Cellular Networks Reconstruction and Static Modelling. Edinburgh Pathway Editor. Construction and Verification of Kinetic Models. Introduction to DBSolve. Enzyme Kinetics Modelling. Kinetic Models of Biochemical Pathways. Modelling of Mitochondrial Energy Metabolism. Application of the Kinetic Modelling Approach to Problems in Biotechnology and Biomedicine. Conclusion and Discussion. References. Index.
£161.50
Taylor & Francis Ltd Lysosomal Pathways of Protein Degradation
Book SynopsisLysosomal Pathways of Protein Degradation looks at cell biology from the view of a lysosome. It summarizes the composition and assembly of lysosomes in mammalian and yeast cells. It also reviews current knowledge about pathways of endocytosis and secretion and how both endocytosed and secreted proteins can be delivered to lysosomes for degradation. In addition, both vesicular and nonvesicular pathways are described for the uptake of cytoplasm and cytosolic proteins by lysosomes. Such pathways include macroautophagy, microautophagy and a direct protein import pathway. Each section contains simple black-and-white figures and tables to illustrate major points. Each section also contains methods used to study segment and ends with future directions of research likely to occur in that particular field. Conditions and molecules that regulate the different pathways of lysosomal proteolysis are also described. The book is written by a single author which lends a uniform style to a volume covering many rapidly-expanding areas of cell biology. A wide variety of readers will benefit from reading this book. Undergraduate and graduate students will find more detailed information about lysosomes than is available in any cell biology textbook. Throughout the book, the aim is to simplify concepts and to unify nomenclature. Even lysosome experts will appreciate the tables and clear definition of terms such as lysosome, autophagic vacuole, and autophagosome. Faculty and researchers that know the basics about lysosomes will find that much has changed in our understanding of these dynamic organelles. Scientists in Biotechnology and Pharmaceutical companies will have a new appreciation of lysosomes after reading this book. The information here could be used to increase the yield of a secreted protein produced by mammalian cells and to target peptide-based drugs to lysosomes for their timed destruction after working in the cytosol.Table of Contents1. Introduction, Methods Used to Study Lysosomes, Terminology, Acidification of Lysosomes, Biogenesis of Mammalian Lysosomes, Biogenesis of the Yeast Vacuole, Degradation of Lysosomal Proteins, Future Directions of Research 2 Degradation of Endocytosed and Plasma Membrane Proteins 3 Lysosomal Degradation of Proteins in the Secretory 4. Degradation of Intracellular Proteins by Macroautophagy 5. Degradation of Intracellular Protein by Microautophagy 6. Selective Pathway for Degradation of Cystolic Proteins by Lysosomes 7. Concluding Remark
£166.25
Taylor & Francis Ltd The CGRP Family: Calcitonin Gene-Related Peptide
Book SynopsisThis book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. The principal speakers have each contributed a chapter and many of the short and poster communications will also be found here. This book follows from the tradition set by the First and Second Meetings in 1992 and 1995 when the proceedings were published. The work is aimed at the specialist in the field, but it is hoped that many of the chapters will also prove useful as introductions to those wishing to gain greater familiarity with the biology and pharmacology of these important peptides. The book begins with a broad overview of the field, past and present. It is followed by two chapters dealing with the "classical" pharmacology of CGRP. In particular there is an account of the pitfalls of the present generation of CGRP antagonists and the dangers of assuming that every action of CGRP is mediated by a CGRP receptor. However the bulk of this section is taken up by the recent developments concerning the cloning of receptors for CGRP and adrenomedullin. An exciting story is emerging of how a single molecule, calcitonin receptor-like receptor (CRLR), can mediate the response to both CGRP and adrenomedullin depending on the presence of different members of a family of accessory proteins, the Receptor Activity Modifying Proteins (RAMPs). This is covered in three chapters and is followed by an account of another accessory protein associated with CGRP responsiveness, Receptor Component Protein (RCP). Following sections of the book deal with the biochemistry, physiology and pharmacology of receptors for the allied peptides amylin and adrenomedullin. The close connections between amylin and calcitonin receptors are highlighted and role of amylin in the regulation of food intake is then considered. The molecular nature of adrenomedullin receptors is addressed in an earlier chapter but in this section their pharmacology is examined. The pathophysiology of CGRP and related peptides formed a significant part of the meeting. Three chapters examine the role of CGRP in vascular disorders, joint dysfunction and gastrointestinal pathology. A separate section considers the role of CGRP in headache and migraine. The book concludes with a selection of the short oral and poster communications and then an important appendix, reflecting a workshop held to discuss the nomenclature of CGRP, amylin and adrenomedullin receptors. As the majority of the active workers in the field were present at this meeting it is hoped that the consensus view presented here might be widely acceptable.Table of ContentsSection 1: Pharmacology and Molecular Biology of CGRP Receptors 1. Multiple Receptors for CGRP and Related Peptides 2. CGRP Receptor Heterogeneity: Use of CGRP8-37 3. Structure Activity Relationship for CGRP 4. The Binding of CGRP and Adrenomedullin to a Cloned Receptor 5. CGRP Receptors, Structure and Function 6. Receptor Activity Modifying Proteins(RAMPS) and CRLR Define the Receptors for CGRP and Adrenomedullin 7. The CGRP-Receptor Component Protein: A Novel Signal Transduction Protein Section 2: Amylin Receptors 8. What Makes an Amylin Receptor? 9. Neuroendocrine Actions of Amylin Section 3: Adrenomedullin Receptors 10. Characterization of Adrenomedullin Receptor Binding in Rat Tissues and Cell Lines 11. Cardiovascular Actions of Adrenomedullin Section 4: General Pathophysiology of CGRP, Amylin and Adrenomedullin 12. Calcitonin Gene-Related Peptide in Gastrointestinal Homeostasis 13. CGRP and Neurogenic Vasodilatation: Role of Nerve Growth Factor in Diabetes 14. Neurogenically-Derived Pathological Hyperaemia in Articular Tissues Section 5: CGRP in Migraine and Headache 15. Evidence of the Involvement of CGRP in Migraine and Cluster Headache: A Physiological Perspective 16. CGRP, CGRP mRNA and CGRP1 Receptor mRNA and Release from the Human Trigeminovascular System Section 6: Short Communications 17. Investigation of Different Pathways for the Relaxant Responses of Human αCGRP and βCGRP on Guinea Pig Basilar Artery 18. CGRP Receptors in Rat Intramural Left Coronary Arteries 19. Discrete Expression of a Putative CGRP Receptor (RDC1) mRNA in the Rat Brain and Peripheral Tissues 20. Amylin-Immunoreactivity in Monkey Hypothalamus 21. Analysis o f Responses to hAmylin and hCGRP in Isolated Resistance Arteries from the Mesenteric Vascular Bed of the Rat 22. Adrenomedullin in the Rat Placenta and Uterus 23. Effects of ADM and CGRP on Erectile Activity in the Cat 24. Evidence for a Specific Endothelial Cell Adrenomedullin Receptor Regulating Endothelin-1 Gene Expression and Synthesis 25. Antimicrobial Effects of Adrenomedullin and CGRP 26. The Comparative Activity of Adrenomedullin and CGRP to Potentiate Inflammatory Oedema Formation 27. The Effects of a Selective CGRP1 Receptor Antagonist, and a Selective Neuronal Nitric Oxide Synthase Inhibitor on Neurogenic Vasodilatation in the Rat 28. CGRP and NO in the Regulation of Blood Flow in Rabbit Knee Joints 29. CGRP Modulates LPS- and Cytokine-Induced iNOS/NO Formation 30. Identification and Regulation of CGRP in T Lymphocytes of the Rat 31. CGRP and Pregnancy 32. Characterization of CGRP Receptors in Human Cranial Arteries 33. CGRP-Mediated Dural Vessel Vasodilation Produces Sensitisation of Trigeminal Nucleus Caudalis Neurones in Rats 34. Mechanism of CGRP Release from Sensory Nerve Terminals in Isolated Trachea of the Rat 35. Expression and Distribution of CGRP Peptide and Receptor in Human Skin
£142.50
Taylor & Francis Ltd Necrotizing Enterocolitis
Book SynopsisThe literature on NEC (necrotizing Enterocolitis), especially in the major textbooks, merely recapitulated what had been written in the past; there has been no new guidance. NEC was viewed as a fait accompli; a sometimes-dire disease that was to be confronted only after it reared its perfidious head. This monograph asks the reader to rethink their approach the NEC. Although, there are no compel others to pursue a way to intervene before the die has been cast. Thus, this book is a promissory note and a challenge.Table of Contents1. The History of Necrotizing Enterocolitis Investigation 2. The Bacteriology of Necrotizing Enterocolitis 3. The Immunology of Necrotizing Enterocolitis 4. The Radiology of Necrotizing Enterocolitis 5. The Medical and ICU Management of Necrotizing Enterocolitis 6. The Surgery of Necrotizing Enterocolitis 7. The Pathology of Necrotizing Enterocolitis 8. The Nutritional Concerns in Necrotizing Enterocolitis 9. The Use of Small Bowel Transplantation in Necrotizing Enterocolitis 10. Afterword
£109.25
Taylor & Francis Ltd Peptide-Based Cancer Vaccines
Book SynopsisThe field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor growth in experimental animal models. The results of animal models are currently translated into clinical applications with all their associated difficulties and heterogeneity. Initial promising data do appear, warranting further research in this area. This book pays tribute to key researchers in the field.Table of Contents1. Identification and Selection of T-Cell Epitopes Derived from Tumor-Associated Antigens for the Development of Immunotherapy for Cancer 2. Mutant Oncogene and Tumor Suppressor Gene Products and Fusion Proteins Created by Chromosomal Translocations as Targets for Cancer Vaccines 3. p53: A Target for T-Cell Mediated Immunotherapy 4. Critical Dependence of the Peptide Delivery Method on the Efficacy of Epitope Focused Immunotherapy 5. Cancer Peptide Vaccines in Clinical Trials 6. Carcinoembryonic Antigen (CEA) Peptides and Vaccines for Carcinoma 7. Studies of M UCl Peptides 8. Cytotoxic T Cell Epitopes and Tissue Distribution of the HER-2/neu Proto-Oncogene: Implications for Vaccine Development 9. Clinical Trials of HER-2/neu Peptide-Based Vaccines 10. Peptides in Prostate Cancer 11. Peptides in Cervical Cancer 12. Peptide Vaccines for the Treatment of Melanoma 13. GplOO and G250: Towards Specific Immunotherapy Employing Dendritic Cells in Melanoma and Renal Cell Carcinoma 14. Melanoma Peptide Clinical Trial
£85.49
Taylor & Francis Ltd Molecular Mechanisms of Muscular Dystrophies
Book SynopsisThere is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters covering a spectrum of muscular dystrophies and one myopathy that represent most of the major muscular dystrophies, and, in particular, those where a molecular understanding of the underlying mechanisms is most advanced, rather than a comprehensive treatise on every muscular dystrophy so far characterized.Table of Contents1. Structure and Function of the Dystrophin-Glycoprotein Complex 2. The Structure and Function of Dystrophin 3. Utrophin in the Therapy of Duchenne Muscular Dystrophy 4. Syntrophin: A Molecular Adaptor Conferring a Signaling Role to the Dystrophin-Associated Protein Complex 5. Molecular and Functional Diversity of Dystrobrevin-Containing Complexes 6. Commonalities and Differences in Muscular Dystrophies: Mechanisms and Molecules Involved in Merosin-Deficient Congenital Muscular Dystrophy 7. Glycosylation and Muscular Dystrophy 8. Overview of the Limb-Girdle Muscular Dystrophies and Dysferlinopathy 9. Caveolin-3 and Limb-Girdle Muscular Dystrophy 10. The Sarcoglycans 11. Sarcomeric Proteins in LGMD 12. Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection 13. Distinct Mechanisms Downstream of the Repeat Expansion Are Implicated in the Molecular Basis of Myotonic Dystrophy Type 1 14. Spinal Muscular Atrophy 15. The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy 16. Cell Adhesion and Signalling in the Muscular Dystrophies 17. Gene Therapies for Muscular Dystrophies 18. Cell Therapies for Muscular Dystrophy
£137.75
Taylor & Francis Ltd Interleukin-10
Book SynopsisInterleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.Table of ContentsPreface 1. Interleukin-10 1A. Structure and Function of IL-10 and the IL-10 Receptor IB. IL-10 Effects on Innate Immunity 1C. Interleukin-10 and Adaptive Immune Response 2. Experimental Models for the Analysis of IL-10 Function III. Genetic Polymorphism of IL-10 and Relevance to Immune Function 3A. Role of IL-10 in Autoimmune Pathology 3B. Interleukin-10 Gene Polymorphisms and Cancer 3C. IL-10 Gene Polymorphisms in Transplantation 3D. IL-10, Genetic Polymorphism and Its Relevance to Age-Related Diseases 4. IL-10: Role in Infectious Diseases V. Role of IL-10 in Allergy 5. Interleukin-10 in Allergic Disease VI. Role of IL-10 in Autoimmune Pathology 6. The Role of IL-10 in Autoimmune Pathology VII. Role of IL-10 in Transplantation 7. Role of Interleukin-10 in Transplantation VIII. Role of IL-10 in Inflammatory Disease 8A. Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis 8B. Interleukin-10 and Psoriasis 8C. IL-10: The Role in Crohn’s Disease 8D. IL-10 and Systemic Lupus Erythematosus 9. Role of IL-10 in Cancer
£133.00
Taylor & Francis Ltd Microarrays and Transcription Networks
Book SynopsisWhile every cell of an organism has an identical genomic content, extremely complex networks exist to tailor the genomic output to the needs of that cell. This program of gene expression is different for every cell type and stage of development. In addition, the cell can respond to its environment by modulating its gene expression program in a fairly dramatic manner. For many decades gene transcription has been investigated in systems from bacteria to mammalian cells and along the way many landmark findings have set new paradigms that often apply across wide evolutionary distances. Studying individual genes, however, especially in mammalian systems has been a painstaking business and although we know the transcription activators and other complexes that control specific genes in minute detail, generalizing these findings has often proven to be difficult. It has become clear that transcription factors do not operate alone but form complex networks in the cell. If one component of this complexity is disturbed then there are repercussions across the entire network, but it has been impossible to study these networks until very recently. The advent of microarray technology within the last decade has revolutionized how we study gene transcription. There are several types of array technology that essentially screen for relative mRNA levels for many thousands of genes at once. We do not focus here on the technology as this has become routine and is available to many researchers. Microarray technology has given us the ability to measure the entire gene expression program of a cell in a single experiment and compare it to other cells thus allowing a global view of cell behaviour at the level of gene transcription. Expression profiling, as this endeavour has become known, is now a relatively simple undertaking and hundreds, probably thousands of papers have been published demonstrating the power of this technology. Expression profiling has been applied to many diverse biological problems and is also being developed as a method for disease diagnosis especially in the cancer classification field. There are constant improvements or modified uses of the technology that are allowing more and more high throughput experiments to be carried out.Table of ContentsPreface 1. Microarrays and Gene Regulation Networks in Yeast 2. Transcription Regulatory Networks in Yeast Cell Cycle 3. Transcriptional Regulatory Networks from Yeasts to Humans 4. Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses 5. The Nuclear Factor-KB Gene Regulatory Network 6. Transcriptional Networks in Mammalian Gene Regulation 7. Deciphering Regulatory Networks Controlled by the NF-kB Transcription Factor c-Rel in T Cells 8. Transcriptional Profiling of the Hepatic Growth Response 9. Transcriptional Responses to DNA Damage: Systems-Level Delineation by Functional Genomics 10. Elucidating Gene Regulatory Networks Underlying Complex Phenotypes: Genetical Genomics and Bayesian Network
£152.00
Taylor & Francis Ltd Tractus Immuno-Logicus: A Brief History of the
Book SynopsisThe history of this text started years ago after reading Wittgenstein’s “Tratactus Logico-Philosophicus”. At some time later, it seemed to me a good idea to follow the “tratactus” structure to attempt to write a minimal description of the immune system. I finally did it for fun and hopefully to be useful to whomever reads it. The text reflects my own personal view of the vertebrate’s immune system (IS). It is centered on concepts and ideas that were developed since 1986 based on work from my own lab1 and from Benedita Rocha’s lab2 and I’m greatly indebted to her for this. I have kept it short and focused on what I believe are the essential features of the IS. I’ve tried to avoid too much detail and most of the complex immunology jargon. If some now fashionable aspects of the IS are only superficially mentioned it is because I feel that they may be not so relevant after all. Perhaps for all these reasons I give no detailed sources and simply refer the reader to some general inspiring non-immunological references. I look forward to raising in the general non-scientific reader an interest for an immune system where lymphocytes are mainly “concerned” with replication, survival factors and homing to the appropriate niche. This is the 1960s “sex, drugs and rock’n roll” view of the IS. Moreover, there are many concepts that are shared with other fields, e.g., ecology, economics. I hope to stimulate quite a lot of discussion among those that study the Immune System. The text opens opportunities on Immunology teaching by focusing on concepts, interactions and their relatedness and all those as one. The readers may build frameworks of cross-references between statements that are not in line to create alternative reading paths. They should interact with each other to compare interpretations and refer to the immunology literature. They may create new connections, add new sub-sections, references and suggest modifications. To the medical doctor or the advanced specialist the text encapsulates the Immune System and provides a novel prism with which to approach Immunology. By attempting to always follow a logical line of thought, I end up by making new statements, some of which remain hypothetical, waiting for experimental testing, that change the current views of the IS. The purpose was that “each” statement should force the reader to stop, think and whenever possible, test. By doing so, I hope to provoke new questions and inspire new experimental approaches and research. While working on this manuscript and looking for inspiration, I played many games of Shanghai II. Sometimes I got the cookie “Wise men learn much from fools…” There are many “fools” in science. Dear reader, please be wise. Antonio A. de Freitas, MD, PhDTable of Contents1. Definition 2. Evolution 3. Development 4. Organization 5. Response and Memory 6. Vaccines 7. Pathology 8. Conclusion 9. The End
£46.99
Taylor Trade Publishing That's Not in My Science Book: A Compilation of
Book SynopsisThe follow-on to the best-selling That's Not in My American History Book explains in everyday language both the ordinary and the bizarre technological marvels that we take for granted and the laws of nature that serve as the baseline for life on earth. Beginning with clear, concise, and entertaining descriptions of the important discoveries that form the basis of our scientific knowledge—-Newtonian mechanics, Einstein's theory of relativity, evolution, and germ theory, to name a few—-the book goes on to tell scientific stories that "are lost between the pages." These include the discovery of the periodic table of elements (and why it matters), the development of miracle drugs such as aspirin and penicillin, the invention of television, the prospects for earthquake prediction, and the genesis of the Internet. Whether it's a fascinating anecdote about the role of zebrafish as stand-in patients for humans or the history of the computer, That's Not in My Science Book will prove to be an engaging read for armchair scientists and students alike.Trade ReviewA rich collection of entrancing specifics...It's hard to imagine anyone—from a young student to his grandfather—being able to dip into this work without becoming absorbed. -- Ed Nelson * Daily Southtown *Filled with facts about things that just increase one's understanding of the world while being constantly entertaining in the process... A book like this will make you the hit of any party simply for all the wonderful and useful trivia it possesses. -- Alan Caruba, Editor, BookViews * Bookviews.Com *The book never failed to entice and enlighten me with fascinating scientific facts and issues... I feel that anyone who has even a passing interest in science will find something that intrigues them in Kate Kelly's book. -- Cynthia Kirkeby * Classbrain *
£11.39
