Description
Book SynopsisThis Annals volume includes invited short reviews on topics presented at the 7th International Cancer Vaccine Symposium “Renaissance of Cancer Immunotherapy”, held September 9-11, 2012 in Florence, Italy. The papers cover the latest progress in basic immunology research and its translation to cancer patients. The meeting and papers pay tribute to the successes in the last few years that have led to the approval of new immunotherapies and the awarding of the Nobel Prize in medicine to three immunologists. The symposium is dedicated to one of these recipients, Dr. Ralph Steinman who discovered dendritic cells, immune cells that are vital in immune responses and immunotherapies for cancer.
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Table of ContentsIntroduction to The Renaissance of Cancer Immunotherapy v
Olivera J. Finn and Gerold Schuler
Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy 1
Matthews D. Vesely and Robert D. Schreiber
Cell-extrinsic effects of the tumor unfolded protein response on myeloid cells and T cells 6
Maurizio Zanetti
Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance 12
Bridget Keenan and Elizabeth M. Jaffee
Integration of epidemiology, immunobiology, and translational research for brain tumors 17
Hideho Okada, Michael E. Scheurer, Saumendra N. Sarkar, and Melissa L. Bondy
Human dendritic cells subsets as targets and vectors for therapy 24
Eynav Klechevsky and Jacques Banchereau
Dendritic cell immunotherapy 31
Rachel Lubong Sabado and Nina Bhardwaj
Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance 46
Dylan J. Johnson and Pamela S. Ohashi
Preventing cancer by targeting abnormally expressed self-antigens: MUC1 vaccines for prevention of epithelial adenocarcinomas 52
Pamela L. Beatty and Olivera J. Finn
Immunological control of cell cycle aberrations for avoidance of oncogenesis: the case of tetraploidy 57
Laura Senovilla, Lorenzo Galluzzi, Maria Castedo, and Guido Kroemer
Ongoing adaptive immune responses in the microenvironment of melanoma metastases 62
Nicolas van Baren and Pierre G. Coulie
Main features of human T helper 17 cells 66
Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi, and Sergio Romagnani
In silico modeling of cancel cell dissemination and metastasis 71
Lu-En Wai, Vipin Narang, Alexandre Gouaillard, Lai Guan Ng, and Jean-Pierre Abastado
Common pathways to tumor rejection 75
Ena Wang, Davide Bedognetti, Sara Tomei, and Francesco M. Marincola
Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy 80
Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto. Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa, and Naoshi Kawamura
