Biochemistry Books
Taylor & Francis Ltd Vitamin C: Its Functions and Biochemistry in
Book SynopsisVitamin C (ascorbic acid) is a key vitamin to animals and plants. This book looks at all aspects of vitamin C; its chemical and biochemical properties, its role in various plants and animals and its effect on our health. Written by an international team of experts, together they represent much of the expertise on vitamin C throughout the world.Table of Contents1. Ascorbate Biosynthesis in Plants, Fungi and Animals. 2. Ascorbic Acid Catabolism- Breakdown Pathways and Products in Plants and Animals. 3. Application of Biotechnology to Ascorbic Acid Manufacture. 4. Ascorbic Acid and Oxidative Stress/ Photoprotection in Plants. 5. Ascorbic Acid and Plant Growth. 6. Ascorbic Acid Uptake and Transport. 7. Membrane Redox Proteins involved in Ascorbate-Mediated Reactions. 8. Ascorbic Acid Recycling. 9. How does Ascorbic Acid Prevent Scurvy? 10. Function of Ascorbic Acid as an Antioxidant. 11. Ascorbic Acid and DNA Damage/ Antioxidant Pro-oxidant Effects of Ascorbate. 12. Ascorbic Acid and Aging. 13. Ascorbic Acid in the Central Nervous System.14. Ascorbic Acid and Inflammation. 15. Ascorbic Acid as an Antioxidant in Atherosclerosis. 16. What Intake of Vitamin C is Required for Optimal Human Health?
£171.00
Presses Polytechniques et Universitaires Romandes Structural and Mediator Lipidomics: A Functional
Book SynopsisLipidomics forms part of the field of metabolomics, which in turn follows on from genomics, transcriptomics, and proteomics, in a top-down manner. It is the study of hydrophobic molecules called lipids; however, lipid molecular species are so numerous that investigators tend to subdivide global lipidomics into targeted lipidomic approaches. This book focuses on structural and mediator lipidomics, with a particular emphasis on their functional aspects. This includes lipids deserving of special interest for their structures (especially as parts of cell membranes or plasma lipoprotein particles) and lipids known for their biological activities, which mediate the action of cell agonists (for example, hormones, growth factors, etc.). The oxygenated metabolites of the major functional w6 and w3 polyunsaturated fatty acids in mammals, in particular arachidonic and docosahexaenoic acids, are presented, with special attention paid to their structure-function relationships. These metabolites are very active, and their biological relevance was recognized early on with a Nobel Prize in Physiology and Medicine in 1982. Finally, general principles for the high performance analysis and characterization of lipid species are also presented. The book has been written for undergraduate students and scientists interested in the field of lipids. Clinicians will also be able to find useful information, due to the numerous references to pathophysiology.Table of ContentsBioactive lipids and their precursors Glycerolipids Lipids antioxidants and polyisoprenes Endocannabinoids Sphingolipids Steroids Methodologies Lipid extraction Physical-chemical analyses Lipidomics approaches Fluoxolipidomics Lipid imaging Plasma lipoproteins Lipid components Functional dynamics
£60.80
Springer Nature Switzerland AG Advancements of Mass Spectrometry in Biomedical
Book SynopsisThis volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.Table of Contents1. Mass Spectrometry for Proteomics-based Investigation2. MALDI profiling and applications in medicine3. Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry4. Proteome imaging: from classic to modern mass spectrometry-based molecular histology5. Mass Spectrometry-Based Tissue Imaging of Small Molecules6. Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase7. Proteomics and non-proteomics approaches to study stable and transient protein-protein interactions8. Contribution of Mass spectrometry-based Proteomics to Discoveries in Developmental Biology9. Profiling optimal conditions for capturing EDEM proteins complexes in melanoma using mass spectrometry10. The Methods employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein–Protein Interactions (PPIs)11. Identification of post-translational modifications (PTMs) of proteins by mass spectrometry12. Sequence Variant and Post-translational Modification Analysis During Cell Line Selection via High-throughput Peptide Mapping13. Selective derivatization of hexahistidine-tagged recombinant proteins14. Investigation of Antibody-Drug Conjugates by Mass Spectrometry15. Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides16. Strategies for Membrane Protein Analysis by Mass Spectrometry17. The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses18. Application of Ion Mobility Mass Spectrometry in Lipidomics19. Mass Spectrometry in Advancement of Redox Precision Medicine20. Applications for mass spectrometry in the study of ion channel structure and function21. Immuno – affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance22. Developing well-annotated species-specific protein databases using comparative proteogenomics23. Stoichiometry of heavy metal binding to peptides involved in Alzheimer’s disease: mass spectrometric evidence24. Role of mass spectrometry in investigating a novel protein: the example of Tumor Differentiation Factor (TDF)25. Mass Spectrometry-Based Biomarkers in Drug Developmen26. Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery27. Proteomic approaches to dissect neuronal signalling pathways28. Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders29. Simplifying the proteome: Analytical strategies for improving peak capacity30. Exploration of nicotine metabolism in Paenarthrobacter nicotinovorans pAO1 by microbial proteomics31. Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics32. Mass spectrometry based comparative proteomics using one dimensional and two dimensional SDS-PAGE of rat atria induced with obstructive sleep apnea33. 2D SDS PAGE in combination with western blotting and mass spectrometry is a robust method for protein analysis with many applications.34. Pulse SILAC approaches to the measurement of cellular dynamics35. Protein Biomarkers in Major Depressive Disorder: an Update36. A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy37. Metabolomics and biomarker discovery38. Analytical Methods for Mass Spectrometry-Based Metabolomics Studies39. Trends in analysis of cortisol and its derivatives40. Detection of biomedically relevant stilbenes from wines by mass spectrometry41. Mass spectrometry as a complementary approach for noncovalently bound complexes based on cyclodextrins42. Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry43. Non-targeted Screening in Environmental Monitoring Programs44. Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and its Future Use for the Molecular Epidemiology of Cancer45. Bottlenecks in proteomics: an update46. Recent Applications of Mass Spectrometry at Clarkson University Index
£112.49
Springer Nature Switzerland AG Concepts in Bioscience Engineering
Book SynopsisThis textbook teaches bioengineers critical concepts about protein three dimensional structures, how proteins fold, and how the folding affects the functioning of the protein. Protein folding has profound effects on the discovery of biopharmaceutical drugs (especially the transport of immunological compounds to their site of action) as well as on tissue engineering. Dr. Dods covers topics in easily understood terms through the use of glossaries heading each chapter and footnotes and summaries at the end of each chapter. The chapters cover disordered proteins and large sequences of disorder that exists within proteins, secondary structure (α-helix and β-pleated structure), tertiary and quaternary structure, post-translational changes, proteopathies, bioengineering approaches used to study protein folding, and computer software for protein folding. For each of these topics the elements of biomolecular imaging, cellular and tissue engineering, and health care systems engineering are built. Molecular engineering concepts such as site-directed mutagenesis are addressed. For reinforcement of the concepts presented in this text, activities and problems (Queries) are included in the chapter. Table of ContentsPreface.- Primary Structure.- Secondary Structure.- Tertiary Structure.- Quaternary Structure.- Post-Translational Changes.- Proteopathies.- Unusual Proteins.- Techniques Used to Study Protein Folding.- Software for Protein Folding.- Bioengineering.- Postscript.
£999.99
Springer Nature Switzerland AG Studies of Epithelial Transporters and Ion
Book SynopsisThis book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.Table of Contents1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells.- 2. Na+-K+-2Cl- Cotransporter.- 3. Thiazide-sensitive NaCl Cotransporter.- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia.- 5. Na+/H+ Exchangers in Epithelia.- 6. Sugar Transport Across Epithelia.- 7. Amino Acid Transporters of Epithelia.- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX).- 9. Urea Transporters in Health and Disease.- 10. H,K-ATPases in Epithelia.- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells.- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters.- 13. ClC-2 Chloride Channels.- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology.- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine.- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator.- 17. TMEM16 Proteins (Anoctamins) in Epithelia.- 18. Epithelial Sodium Channels (ENaC).- 19. ROMK and Bartter Syndrome Type 2.- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron.- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels.- 22. KCa3.1 in Epithelia.- 23. BK Channels in Epithelia.- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels.- 25. KCNE regulation of KCNQ channels.- 26. Orai Channels.- 27. Trp Channels in Renal Epithelia.- 28. P2X receptors in Epithelia.- 29. The Polycystins and Polycystic Kidney Disease.- 30. Renal Aquaporins in Health and Disease.
£999.99
Springer Nature Switzerland AG Nutritional Management and Metabolic Aspects of
Book SynopsisElevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form. Table of ContentsProtein homocysteinylation and cytotoxicityGlutathione, betaine and primary prevention of hyperhomocysteinemiaB vitamins supplementation and hyperhomocysteinemia managementFunctional foods and hyperhomocysteinemiaMedicinal plants therapeutics action and hyperhomocysteinemiaHomocysteine-dependent transulfuration and transmethylation pathways Clinical aspects of hyperhomocysteinemia Genetic defects of enzymes and homocysteine homeostasis Hyperhomocysteinemia and oxidative stress Hyperhomocysteinemia and the pathogenesis of chronic diseases Novel biomarkers for hyperhomocysteinemia and oxidative stress Epigenetic effects of hyperhomocysteinemia
£999.99
Springer Nature Switzerland AG Proteinkinase Inhibitors
Book SynopsisThis book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.Table of ContentsProteinKinase-Inhibitors: A Story of Success.- Function, Structure and Topology of Proteinkinases.- Molecular Modelling.- Case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR.- Achieving high level of selectivity for kinase inhibitors.- Inhibitors of c-Jun N-terminal kinase 3.- Exploiting kinase inhibitors for cancer treatment - An Overview of Clinical Results and Outlook.- Covalent Janus Kinase 3 Inhibitors.
£98.99
Springer Nature Switzerland AG Proteinkinase Inhibitors
Book SynopsisThis book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.Table of ContentsProteinKinase-Inhibitors: A Story of Success.- Function, Structure and Topology of Proteinkinases.- Molecular Modelling.- Case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR.- Achieving high level of selectivity for kinase inhibitors.- Inhibitors of c-Jun N-terminal kinase 3.- Exploiting kinase inhibitors for cancer treatment - An Overview of Clinical Results and Outlook.- Covalent Janus Kinase 3 Inhibitors.
£999.99
Springer Nature Switzerland AG Epigenetics and Proteomics of Leukemia: A Synergy
Book SynopsisThis book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.Table of ContentsOverview / IntroductionSection I: Epigenetics in Leukemia Chapter 1: Genetic and Epigenetic Alterations in Leukemia Chapter 2: Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment Chapter 3: Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation DNA Methylation and Epigenetic Regulation Chromatin Functional Regulation by Histone Modification Chapter 4: Approaches to Epigenetic Treatment of LeukemiaSection II: Proteomics in Leukemia Chapter 5: Proteome in Leukemic vs. Differentiated Leukemia Cells Chapter 6: Protein Phosphorylation in Leukemia Chapter 7: Computational Methods for Proteome Analysis 2DE Fractionation and Visualization Proteomic Data Processing Proteomic Data Analysis Image Acquisition and Data AnalysisSection III: Protein Localization in Leukemia Chapter 8: Protein Translocation into the Nucleus during Leukemia Cell Differentiation Chapter 9: Protein Visualization in Leukemic Cells Chapter 10: Computational Methods for Protein Localization Estimation Fluorescent Image Processing Fluorescent Image Acquisition and AnalysisSection IV: Future Therapy in Leukemia
£999.99
Springer Nature Switzerland AG Tumor Suppressor Par-4: Structural Features,
Book SynopsisPar-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.Table of ContentsIntroductionChapter 1. Discovery and Overview of Par-4Chapter 2. Significance of Par-4 Interaction with aPKCChapter 3. Structural Analysis of the C-terminal domain of Par-4Chapter 4. Crystallization and crystallographic analysis of the C-terminal domain of Par-4 (PAWR)Chapter 5. Role of ubiquitinase FBX045 in Par-4 regulationChapter 6. Regulation of Par-4 by type II phosphatidylinositol 4-kinase βChapter 7. Role of Par-4 in regulation of cell death by circumin and ceramideChapter 8. Par-4 in dissociation induced cell death in human pluripotent stem cellsChapter 9. Role of Par-4 in EMTChapter 10. Bacillus thuringiensis Induced Par-4 and Apoptosis in Human CellsChapter 11. Role of Par-4 in ZebrafishChapter 12. Role of Par-4 in GRP78 translocationChapter 13. Interaction of THAP1 with Par-4 in PML bodiesChapter 14. Regulation of DAPK and AMIDA by Par-4Chapter 15. Regulation of Par-4 by CK2 kinase
£999.99
Springer Nature Switzerland AG Jasmonates and Salicylates Signaling in Plants
Book SynopsisDemand for agricultural crops and nutritional requirement continues to escalate in response to increasing population. Also, climate change exerts adverse effects on agriculture crop productivity. Plant researchers have, therefore, focused to identify the scientific approaches that minimize the negative impacts of climate change on agricultural crops. Thus, it is the need of the hour to expedite the process for improving stress tolerance mechanisms in agricultural crops against various environmental factors, in order to fulfil the world’s food demand. Among the various applied approaches, the application of phytohormones has gained significant attention in inducing stress tolerance mechanisms.Jasmonates are phytohormones with ubiquitous distribution among plants and generally considered to modulate many physiological events in higher plants such as defence responses, flowering and senescence. Also, jasmonates mediate plant responses to many biotic and abiotic stresses by triggering a transcriptional reprogramming that allows cells to cope with pathogens and stresses. Likewise, salicylates are important signal molecules for modulating plant responses to environmental stresses. Salicylic acid influences a range of diverse processes in plants, including seed germination, stomatal closure, ion uptake and transport, membrane permeability and photosynthetic and growth rate.Understanding the significant roles of these phytohormones in plant biology and from agriculture point of view, the current subject has recently attracted the attention of scientists from across the globe. Therefore, we bring forth a comprehensive book “Jasmonates and Salicylates Signalling in Plants” highlighting the various prospects involved in the current scenario. The book comprises chapters from diverse areas dealing with biotechnology, molecular biology, proteomics, genomics, metabolomics, etc. We are hopeful that this comprehensive book furnishes the requisite of all those who are working or have interest in this topic.Table of ContentsChapter 01Jasmonates and Salicylates: Mechanisms, Transport and Signalling during Abiotic Stress in PlantsAkbar Hossain1,*, Zahoor Ahmad2, Debjyoti Moulik3, Sagar Maitra4, Preetha Bhadra5, Adeel Ahmad6, Sourav Garai7, Mousumi Mondal7, Anirban Roy8, Ayman El Sabagh9,10, Tariq Aftab11Chapter 02Salicylic acid and jasmonic acid in generating salt stress tolerant plantsAnkur Singh, Aryadeep Roychoudhury*Chapter 03Role of Jasmonic and Salicylic acid signaling in plants under UV-B stressKrishna Kumar Choudhary1, Suruchi Singh2, Madhoolika Agrawal3 and S. B. Agrawal3*Chapter 04Plant Responses to Exogenous Salicylic and Jasmonic Acids under Drought StressKazem Ghassemi-Golezani1*, Salar Farhangi-Abriz2Chapter 05Role of jasmonic acid and salicylic acid signaling in secondary metabolite production Samapika Nandy, Tuylee Das, Abhijit Dey*Chapter 06Role of jasmonates and salicylates in plant allelopathyAnam Asif1, Mohammad Affan Baig2*, M. Badruzzaman Siddiqui1Chapter 07Jasmonate: A versatile messenger in plantsPriyanka Singh, Yamshi Arif, Husna Siddiqui and Shamsul Hayat*Chapter 08The crucial role of jasmonates in enhancing heavy metals tolerance in plantsAli Raza1*, Sidra Charagh2, Shiva Najafi Kakavand3,4, Manzer H. Siddiqui5Chapter 09Jasmonates: The Fine-Tuning Bio-Regulators and their Crosstalk with Plant Reproductive BiologyDeepu Pandita*Chapter 10Role of Jasmonates in pathogenesis and crosstalk of Jasmonates with other hormonesShreshtha Yadav1, Simran1, Nisha Sella1, Shabir A. Rather2*Chapter 11Methyl Jasmonate and its Application for Improving Postharvest Quality of Fruits Deep Lata1, Anusree Anand1, Burhan Ozturk2, Riadh Ilahy3 , Md. Shamsher Ahmad4, and Mohammed Wasim Siddiqui4*Chapter 12Salicylic acid signalling under stress conditions in plantsTibor Janda*, Kinga O. Gondor, Magda Pál, Gabriella SzalaiChapter 13Function of Mediator in regulating salicylic acid mediated signaling and responses in plantsShubham Kumar Sinha, Koppolu Raja Rajesh Kumar*Chapter 14The Hidden Pathways Affecting Salicylic Acid Signaling in PlantsBahareh Hekmatdoust Tabrizi1, Neda Fattahi1, Rachel Backer2, Zahra Dehghanian3, Khosro Balilashaki4, Behnam Asgari Lajayer5*, and Tess Astatkie6 Chapter 15Salicylic Acid (SA): Its interaction with different molecules in the stress tolerance signaling pathwaysAparna Pandey1, Nidhi Verma1, Shikha Singh1, Gausiya Bashri2 and Sheo Mohan Prasad1*
£999.99
Springer Nature Switzerland AG The Language of Living Matter: How Molecules
Book SynopsisThis book, by an eminent scientist and philosopher, provides strong evidence for the claim that language is a general principle of Nature, rooted exclusively in physical and chemical laws. The author’s radical idea inevitably leads us to view the essence, origin and evolution of life in a completely new light. It shifts the coordinates of our scientific world-view in favor of an overarching concept of language that is able to bridge the gap between matter and mind. At the same time, it removes a blind spot in the Darwinian concept of evolution. To justify this far-reaching idea, the book takes a long and deep look at our scientific and philosophical thinking, at language as such, at science’s claim to truth, and at its methods, unity, limits and perspectives. These are the cornerstones structuring the book into six thematically self-contained chapters, rounded off by an epilogue that introduces the new topic of Nature’s semantics. The range of issues covered is a testimony to how progress in the life sciences is transforming the whole edifice of science, from physics to biology and beyond. The book is aimed at a broad academic and general readership; it requires no mathematical expertise.Table of Contents1. Language: Gateway to the World2. Truth: The Regulative Principle of Cognition3. Methods: Ways of Gaining Knowledge4. Unity: The Deep Structure of Science5. Limits: Insights into the Reach of Science6. Perspectives: Designing Living Matter7. Epilogue: Nature’s SemanticsAuthor IndexSubject Index
£39.00
Springer Nature Switzerland AG Tools and Trends in Bioanalytical Chemistry
Book SynopsisThis textbook covers the main tools and techniques used in bioanalysis, provides an overview of their principles, and offers several examples of their application and future trends in diagnosis.Chapters from expert contributors explore the role of bioanalysis in different areas such as biochemistry, physiology, forensics, and clinical diagnosis, including topics from sampling/sample preparation, chemometrics in bioanalysis to the latest techniques used in the field. Particular attention is given to the recent advances in the application of mass spectrometry, NMR, electrochemical methods and separation techniques in bioanalysis. Readers will also find more about the application of microchip-based devices and analytical microarrays. This textbook will appeal to graduate/advanced undergraduate students in Chemistry, Biology, Biochemistry, Pharmacy, and Chemical Engineering. It is also a useful resource for researchers and professionals working in the fields of biomedicine and veterinary sciences, with clear explanations and examples of how the different bioanalytical devices are applied for clinical diagnosis.Table of ContentsSee attachments
£999.99
Springer Nature Switzerland AG Nutrition Guide for Physicians and Related
Book SynopsisThis fully updated and expanded third edition is a reference guide on nutrition and its clinical implications for health and disease through the life-cycle. The book endeavors to address the needs of those who would most benefit from up-to-date information on recent advances in the field of nutrition. Written by experts in the field, chapters cover a diverse range of nutritional areas that present a succinct overview of recent thinking and discoveries that have the greatest capacity to aid physicians and other healthcare professionals in improving the nutritional health of their clients. The text is divided into eight parts. Part one and two address the nutrient requirements and special nutrition-related issues for people across all stages of the lifespan—from pregnancy and infancy through the adolescent years to the older adult years. Part three summarizes the role of nutrition in the prevention and management of chronic conditions frequently seen in clinical practice, including obesity, diabetes, bone disorders, coronary heart disease, hypertension, and cancer. Part four describes different dietary patterns (the Mediterranean diet, the DASH diet, the vegetarian diet, and the ketogenic diet). Part five describes nutrition challenges specific to surgery and several different acute diseases and disorders (gastrointestinal disorders, food allergy and intolerance, diseases of the liver and pancreas, kidney disease, eating disorders, bariatric surgery, sarcopenia, and drug interactions with food). Part six looks at different aspects of the diet (coffee, tea, dietary fat, dietary sugars, energy drinks, alcohol, dietary fiber, vitamins, minerals, and the gut microbiome). Part seven examines a range of factors that influence dietary health decisions (creating nutritional behavior change, methods for assessing nutritional status, Dietary Reference Intakes, an overview of the diet and food guides, food labels, and sources of nutrients). Finally, part eight looks at dietary supplements (including the problem of dishonest marketing) and false and misleading information in the area of nutrition. The growing nutritional impact of COVID-19 is discussed throughout the book where appropriate.Nutrition Guide for Physicians and Related Healthcare Professions Third Edition serves as a comprehensive guide that is organized by age/lifespan, nutrition therapy in relation to chronic disease and COVID, diet and its role in prevention, dietary requirements and recommendations, and influencing health decisions for the patient. It is a valuable resource of practical and easy-to-access information on nutrition for physicians, nurses, pharmacists, and others in their daily practice.Table of ContentsPart I: Introduction.- Why Nutrition Matters in Clinical Practice.- Part II: Nutrition Consideration Across the Lifespan.- Pregnancy: Preparation for the Next Generation.- Infants: Transition from Breast to Bottle to Solids.- Young Children: Preparing for the Future.- Nutrition in Adolescence.- Nutritional Challenges of Girls and Woman.- Healthy Aging: Nutrition Concepts for Older Adults.- Dietary Considerations for Postmenopausal Women.- Dietary Influence on Cognitive Function in the Elderly.- Part III: Nutrition for the Prevention and Management of Chronic Diseases.- Inherited Metabolic Disorders and Nutritional Genomics: Choosing the Wrong Parents.- Obesity: Understanding and Achieving a Healthy Weight.- Nutrition Therapy for the Treatment of Type 1 Diabetes.- Nutrition Therapy for Prevention and Treatment of Type 2 Diabetes.- Osteoporosis and Bone Health: Sound Suggestions for Stronger Bones.- Coronary Heart Diseasee: Nutritional Interventions for Prevention and Therapy.- Dietary Influence on Blood Pressure.- Diet, Physical Activity, and Cancer Prevention.- Nutritional Prevention of Irritable Bowel and Gastrointestinal Disorders.- Part IV: Nutritional Requirements Following Surgery and Acute Disease.- Dietary Considerations During Chemotherapy.- Role or Nutrition in Understanding Common Gastrointestinal Disorders.- Food Allergy and Intolerance: Diagnosis and Nutritional Management.- Nutrition in Patients with Diseases of the Liver and Pancreas.- Medical Nutrition Therapy for Kidney-Related Disorders.- Eating Disorders: Disorders of Under and Over Nutrition.- Nutritional Considerations for the Treatment of Depression.- Nutritional Considerations Following Bariatric Surgery.- Nutrition for Sarcopenia Prevention.- Drug Interactions with Food and Beverages.- Part V: Food and Nutrient Health Effects.- Coffee Consumption and its Impact on Health.- Health Effects of Tea Consumption.- Dietary Fat: the Good, the Bad, and the Ugly.- Dietary Sugar Intake: Is There a Best Recommendation.- Dietary Recommendations for Juices and Soft Drinks.- Sports Beverages for Optimizing Physical Performance.- Energy Drinks and Human Healthy.- What is the Best for the Patient: Abstinence or Moderate Alcohol Consumption?.- Dietary Fiber: All Fibers are not Alike.- Vitamins: The Essentials.- Mineral Nutrients: From Macro to Ultra Trace.- Nutritional Influence on the Gut Microbiome.- Part IV: Influencing Dietary Health Decisions.- Guidelines for Nutrition Screening, Assessment, and Referrals in the Clinical Setting.- Nutritional Status: An Overview of Methods for Assessment.- Food Synergy, Nutritional Science to Food Guides.- Dietary Supplements: Navigating a Minefield.- A Plague of False and Misleading Information.- Dietary Reference Intakes: Cutting Through the Confusion.- Food Labels and Sources of Nutrients: Sorting the Wheat from the Chaff.- Part VII: Conclusions.- What Needs to Change for Nutritional Health to Improve?.- Appendix A: Aids to Calculations.
£999.99
Springer Nature Switzerland AG Basic Organic Chemistry for the Life Sciences
Book SynopsisThis textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions. Table of Contents
£999.99
Springer International Publishing AG Deuterium Oxide and Deuteration in Biosciences
Book SynopsisThis new book provides comprehensive coverage of the subjects of deuterium oxide and deuteration in biosciences, with an emphasis on the biochemical, biomedical, and pharmacological aspects. Deuterium oxide and deuteration effects also offer various implications for health-related issues, including diseases, vaccines and drugs. Organized in six sections, the chapter topics include the role of regular and heavy water in biosciences, and their implications to biomolecules, biochemical processes, health-related research, and pharmacology. Due to the broad scope, the book may be used as a supplemental text for upper-level undergraduate and graduate courses in the related fields of biochemistry, biology, biomedical sciences, biophysics, and pharmacology. Researchers and pharmaceutical industry professionals will also find the content useful in order to gain knowledge and better understand the implications of deuterium oxide and deuteration research.Table of ContentsSection I. Roles of regular and heavy water in biosciences Overview: background and applications Characteristics of deuterium oxide versus hydrogen oxide Section II. Molecular interactions of deuterium versus hydrogen oxide Deuterium bonding versus hydrogen bonding Hydrophobic interaction in D2O versus H2O Section III. Implications of deuterium oxide and deuteration in biological Systems Deuterium oxide and deuteration effects on biomolecules Effects of D2O and deuteration on biomembranes Section IV. Applications of D2O and deuteration to biochemical reactions Biochemical effects of deuterium oxide and deuteration Physical methods for investigating D2O and deuteration effects Section V. Exploration of deuterium oxide and deuteration in health-related research Living cells grown in deuterium oxide and deuteration Deuterium oxide and deuteration effects on health issues Section VI. Applications of deuterium oxide and deuteration to pharmacology Deuterium oxide effects on thermostability of vaccines Deuterium oxide and deuteration effects on pharmacology
£104.49
Springer International Publishing AG Biochemistry and Cell Biology of Ageing: Part III
Book SynopsisThis book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.Table of ContentsSee Attachments
£999.99
Springer International Publishing AG Ein praktischer Leitfaden für Protein Engineering
Book SynopsisDieses Lehrbuch führt den Leser auf zugängliche und ansprechende Weise in die Grundlagen der Proteinexpression und -entwicklung ein. Verschiedene Fallstudien veranschaulichen jeden Schritt von der ersten Sequenzsuche in Online-Datenbanken über Plasmiddesign und molekulare Klonierungstechniken bis hin zur Proteinreinigung und -charakterisierung. Darüber hinaus erhält der Leser praktische Tipps für eine erfolgreiche Karriere als Proteiningenieur. Da das Protein-Engineering eine grundlegende Technik in fast allen molekularbiologischen Labors ist, richtet sich das Buch an fortgeschrittene Studenten und Doktoranden, die in der Molekularbiologie, Biotechnologie und verwandten wissenschaftlichen Bereichen arbeiten.Table of ContentsTeil I: Kapitel 1: Eine kurze Geschichte des Protein-EngineeringKapitel 2: Von der DNA zum funktionellen Protein - eine AuffrischungKapitel 3: Grundlegende Labor- und RechentechnikenTeil II:Kapitel 4: Strategien des Protein-EngineeringKapitel 5: Computergestützte Werkzeuge für das Protein-EngineeringKapitel 6: GenisolierungKapitel 7: Rationaler Entwurf Kapitel 8: Gezielte EvolutionKapitel 9: ProteinmodifikationTeil III:Kapitel 10: Berufsperspektiven eines ProteiningenieursKapitel 11: Gespräche mit Proteiningenieuren
£36.09
De Gruyter Biochemische Grundlagen der Zahnmedizin
Book Synopsis
£95.00
De Gruyter The Biologic Role of Dehydroepiandrosterone
Book Synopsis
£215.18
De Gruyter Novel cancer-related biomarkers
Book SynopsisVarious KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.
£17.10
De Gruyter Cannabis Chemistry and Biology: Fundamentals
Book SynopsisThis book serves as an introduction to graduate students and early career researchers on chemistry and botany of the cannabis plant. Cannabis botany, propagation, biotechnology, chemistry, cannabinoids and their biosynthesis, chemovars of cannabis and their identification as well as the other chemical classes of compounds known to exist in the plant. Analytical method are discussed to establish identity and Potency changes over the years in the United States. This book will build a base of knowledge on the complexity of cannabis chemistry. Features Introduction to the fundamental chemistry and botany of Cannabis. State of the art research on Cannabis sativa. The history, botany, major chemical classes of cannabis as well as methods of analysis and potency trends over several decades in the United States. Written by prominent scientists in the field of cannabis. The Cannabis Chemistry Subdivision of the American Chemical Society recently founded in 2022 the ElSohly Award sponsored by Heidolph North America in honour of Prof. Mahmoud A. ElSohly. This award provides researchers, students, and industry professionals with resources to present their work at the Spring National Meeting of the American Chemical Society at the ElSohly Award Symposium. More information: https://cann-acs.org/wp-content/uploads/2020/12/CANN-Postcard-Award.pdf
£70.77
De Gruyter Riedel Moderne Anorganische Chemie
Book Synopsis
£84.55
Springer International Publishing AG Plant Aquaporins: From Transport to Signaling
Book SynopsisAquaporins are channel proteins that facilitate the diffusion of water and small uncharged solutes across cellular membranes. Plant aquaporins form a large family of highly divergent proteins that are involved in many different physiological processes. This book will summarize the recent advances regarding plant aquaporins, their phylogeny, structure, substrate specificity, mechanisms of regulation and roles in various important physiological processes related to the control of water flow and small solute distribution at the cell, tissue and plant level in an ever-changing environment.Table of ContentsStructural basis of permeation function of plant aquaporins.- Heteromerization of plant aquaporins.- Plant aquaporin trafficking.- Plant aquaporin post-translational regulation.- Plant aquaporins and cell elongation Aquaporins and root water uptake.- Aquaporins and leaf water relations.- Roles of aquaporins in stomata.- Aquaporins and abiotic stress.- Plant aquaporins and signaling.- Role of aquaporins in maintenance of xylem hydraulic capacity.- Plant aquaporins and CO2.- NIP subfamily.- Plant aquaporins and metalloids.- Plant aquaporins and mycorrhizae: their regulation and involvement in plant physiology and performance.
£149.99
Editions Universitaires Europeennes Breast anticancer drug tamoxifen and its
Book Synopsis
£17.86
Wiley-VCH Verlag GmbH Biochemie kompakt für Dummies
Book SynopsisStehen Sie auf Kriegsfuß mit der Biochemie? Diese ganzen Formeln und Reaktionen sind überhaupt nicht Ihr Ding? Die nächste Prüfung steht vor der Tür? Kein Problem! "Biochemie kompakt für Dummies" erklärt Ihnen das Wichtigste, was Sie über Biochemie wissen müssen. Sie werden so einfach wie möglich und so komplex wie nötig in die Welt der Kohlenhydrate, Lipide, Proteine, Nukleinsäuren, Vitamine, Hormone und Co. eingeführt. So leicht und kompakt kann Biochemie sein.Table of ContentsEinleitung 19 Teil I: Vorhang auf: die Grundlagen der Biochemie 23 Kapitel 1: Chemie: Was Sie darüber wissen sollten 25 Kapitel 2: Einfach eintauchen: die Chemie des Wassers 39 Kapitel 3: Kohlenstoff und die organische Chemie 53 Kapitel 4: Ein wenig Biologie: die Zelltypen 65 Teil II: Das Fleisch der Biochemie: Proteine 71 Kapitel 5: Aminosäuren: die Bausteine der Proteine 73 Kapitel 6: Struktur und Funktion von Proteinen 85 Kapitel 7: Enzymkinetik: mit Hilfe schneller ans Ziel 97 Teil III: Kohlenhydrate, Lipide, Nukleinsäuren und mehr 115 Kapitel 8: Wir wecken Gelüste: Kohlenhydrate 117 Kapitel 9: Lipide und Membranen 131 Kapitel 10: Nukleinsäuren und der Code des Lebens 147 Kapitel 11: Vitamine und Nährstoffe 159 Kapitel 12: Die stillen Akteure: Hormone 173 Teil IV: Bioenergetik und Reaktionswege 183 Kapitel 13: Leben und Energie 185 Kapitel 14: Vom Katabolismus zum Anabolismus 191 Kapitel 15: Ein »anrüchiges« Thema: Stickstoff in biologischen Systemen 221 Teil V: Genetik: Warum wir sind, was wir sind 229 Kapitel 16: DNA kopieren 231 Kapitel 17: Schön abschreiben bitte! RNA- Transkription 253 Kapitel 18: Korrekt übersetzen – die Translation 267 Teil VI: Der Top- Ten- Teil 279 Kapitel 19: Zehn beeindruckende Einsatzgebiete der Biochemie (plus eins) 281 Abbildungsverzeichnis 287 Stichwortverzeichnis 293
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Molekular- und Zellbiologie: Aktuelle Themen
Book SynopsisTable of ContentsFunktionsanalyse zellulärer Strukturproteine durch Mikroinjektion.- Methoden zur Charakterisierung von membranständigen Rezeptoren: Biochemische Charakterisierung und Reindarstellung des Acetyl-LDL-Rezeptors von Makrophagen.- Isolation und Charakterisierung differenzierungsspezifischer Antigene der Milchdrüse.- Sequenzieren von DNA.- Mathematische und informationstheoretische Hilfsmittel zur DNA-Sequenzierung und Sequenzanalyse.- Vektor-Wirt Systeme zur DNA-Klonierung in E. coli.- Zelloberflächenproteine — Klonierung ihrer Gene durch DNA vermittelten Gentransfer und fluoreszenzaktivierte Zellsortierung.- Linkshelikale Z-DNA: „DNA-Supercoiling“ und Bindung von Anti-Z-DNA Antikörpern.- Mikroklonierung von Chromosomenabschnitten.- Molekular- und Cytogenetik sortierter Methaphasenchromosomen.- Chromosomenspezifische DNA-Bibliotheken in der Humangenetik.- Gen-Injektion und Transkript-Analyse in der Xenopus-Oocyte.- Gentransfer in eukaryotische Seilen.- SV40 als Modellsystem zum Studium eukaryontischer Genregulation.- Hormonal gesteuerte Transkription — Definition der regulatorischen Sequenzen im Genom des Maus-Mammatumorvirus.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Glycoscience: Chemistry and Chemical Biology
Book SynopsisAs a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.Table of Contents1 General Principles.- 1.1 Structure and Conformation of Carbohydrates.- 1.2 General Occurance and Properties of Carbohydrates.- 2 General Synthetic Methods.- 2.1 Reactions at Oxygen Atoms.- 2.2 Oxidation, Reduction and Deoxygenation.- 2.3 Heteroatom Exchange.- 2.4 Anhydrosugars.- 2.5 C-C Bond Formation.- 2.6 C=C Bond Formation.- 2.7 Degradations and Rearrangement Reactions.- 3 Chemical Glycosylation Reactions.- 3.1 Introduction to Glycosylation Reactions.- 3.2 Glycosyl Halides.- 3.3 Glycosyl Trichloroacid Imidates.- 3.4 Other Anomeric Esters.- 3.5 O-Glycosyl Donors.- 3.6 S-Glycosylation.- 3.7 Glycal Derivatives.- 3.8 Anomeric Anhydro Sugars.- 3.9 C-Glycosylation.- 4 Monosaccharides.- 4.1 Occurance, Significance and Properties.- 4.2 Monosaccharides and Polyols in Foods.- 4.3 De Novo Synthesis of Monosaccharides.- 4.4 Monosaccharides as Chiral Pools for the Synthesis of Complex Natural Compounds.- 4.5 Monosaccharides as Scaffolds for the Synthesis of Novel Compounds.- 4.6 Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis.- 4.7 Carbohydrate Metal Complexes.- 5 Oligosaccharides.- 5.1 Occurrence, Significance and Properties.- 5.2 Sucrose and Related Oligosaccharides.- 5.3 Oligosaccharides in Food and Agriculture.- 5.4 Combinatorial Methods in Oligosaccharide Synthesis.- 5.5 Solid Phase Methods.- 5.6 Stereoselective Synthesis of ß-Manno Glycoside.- 5.7 Silalylation.- 5.8 Enzymatic Glycosylation by Tranferases.- 5.9 Enzymatic Glycosylation by Hydrolases.- 6 Complex Polysaccharides.- 6.1 Occurence, Significance and Properties.- 6.2 Starch.- 6.3 Cellulose and Hemicellulose.- 6.4 Gums and Related Polysaccharides.- 6.5 Bacterial Cell Wall Components.- 6.6 Fungal Cell Wall Components.- 6.7 Structure-Activity Relationship of Glycosaminoglycans.- 7 Glycolipids.- 7.1 Occurence, Significance and Properties.- 7.2 Synthesis.- 7.3 Biosynthesis and Degradation.- 7.4 Glycosylphosphatidylinositols.- 8 Glycoproteins.- 8.1 Occurence and Significance.- 8.2 Properties.- 8.3 Synthesis and Applications of Biologically Relevant Glycopeptides and Glycoproteins.- 8.4 Glycosilylation Engineering of Glycoproteins.- 8.5 Glycoprotein Analysis.- 9 Glycomimetics.- 9.1 Azaglycomimetics: Synthesis and Chemical Biology.- 9.2 Carbasugars: Synthesis and Functions.- 9.3 Sulfur Containing Glycomimetics.- 9.4 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids.- 9.5 Non-Sugar Glycomimetics.- 10 Key Technologies and Tools for Functional Glycobiology.- 10.1 Introduction.- 10.2 Microarrays.- 10.3 Chemical Probes and Monitoring.- 10.4 Glycomics and Mass Spectrometry.- 10.5 Bioinformatical Tools.- 11 Biosynthesis and Degradation.- 11.1 Introduction.- 11.2 Biosynthesis and Degradation of Monosaccharides.- 11.3 Biosynthesis of Oligosaccharides and Polysaccharides.-11.4 Degradation of Oligosaccharides and Polysaccharides.- 12 Glycomedicine.- 12.1 Novel Approaches for Glycodrug Discovery.- 12.2 Biomedicine of Monosaccharides.- 12.3 Mammalian Carbohydrate-Lectin Interactions.- 12.4 Multivalency in Protein-Carbohydrate Recognition.- 12.5 Synthesis of Heparin-Fragments.- 12.6 Biomedicine of Glycolipids and Glycosphingolipids.- 12.7 Biomedicine of Enkephalin-Derived Glycopeptide Analgesics.- 12.8 Antitumor and Antimicrobial Glycoconjugates.- 12.9 Biomedicine of Glycosylated Natural Compounds.- 12.10 Mucin-based Vaccines.- 12.11 Polysaccharide-based Vaccines
£404.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Organic Mechanisms: Reactions, Stereochemistry
Book Synopsis“Much of life can be understood in rational terms if expressed in the language of chemistry. It is an international language, a language without dialects, a language for all time, a language that explains where we came from, what we are, and where the physical world will allow us to go. Chemical Language has great esthetic beauty and links the physical sciences to the b- logical sciences. ” from The Two Cultures: Chemistry and Biology by Arthur Kornberg (Nobel Prize in Physiology and Medicine, 1959) Over the past two centuries, chemistry has evolved from a relatively pure disciplinary pursuit to a position of central importance in the physical and life sciences. More generally, it has p- vided the language and methodology that has unified, integrated and, indeed, molecularized the sciences, shaping our understanding of the molecular world and in so doing the direction, development and destiny of scientific research. The “language of chemistry” referred to by my former Stanford colleague is made up of atoms and bonds and their interactions. It is a s- tem of knowledge that allows us to understand structure and events at a molecular level and increasingly to use that understanding to create new knowledge and beneficial change. The words on this page, for example, are detected by the eye in a series of events, now generally understood at the molecular level.Trade ReviewFrom the reviews:"The new edition of the textbook of R. Bruckner is accurate, all important modern mechanistic and synthetic concepts of organic chemistry are presented in a very didactic fashion, a superb book to put in the hands of all who would want to learn synthetic organic chemistry or refresh their knowledge."Paul Knochel, Ludwig-Maximilians-University Munich "Over its three editions, Professor Bruckner has significantly fine-tuned his outstanding textbook titled ‘Organic Mechanisms’, now available in English. This text is aimed squarely at students that have completed a typical one-year introductory course in organic chemistry and now wish to continue refining their understanding of the subject. At this level, the text is appropriately focused on providing the reader with an enhanced fundamental understanding of an ambitious range of organic reactions. Along with reminding the reader about fundamental principles necessary to understand the topic, Bruckner’s updated edition also provides a solid physical organic perspective on a wide range of processes. The text is not meant to be an exhaustive survey of reactions, but more of a sound introduction to the underlying principles that control reactivity in variety of transformations that chemistry students should be familiar with. The book, therefore, is particularly well suited for “intermediate” and “advanced” classes in organic chemistry, usually found in upper class electives and introductory graduate classes. The book will also serve as a valuable starting point for the more experienced chemist wishing to brush-up on organic transformations that they might be less familiar with.” Marc L. Snapper, Boston CollegeThis updated version of Professor Brückner’s ‘Organic Mechanisms’ provides a thorough overview of modern organic synthesis that is both comprehensive and accessible to chemists with all levels of experience. Detailed reaction mechanisms are illustrated with clear schemes that effectively convey the electronic and structural principles influencing reactivity and selectivity for the most common transformations used in organic synthesis. The pragmatic division of the material into introductory and more advanced sections enables the text to be used both as a teaching resource for both undergraduate chemistry students and researchers from allied disciplines and as a valuable text for experienced researchers. The book prompts the reader to readily grasp important concepts, while providing ample scope for extension and development of more advanced students of organic chemistry. ‘Organic Mechanisms’ is also a valuable resource for those involved in the application and practice of organic synthesis on a professional level. The range of topics discussed provides an up-to-date compendium of current methods, of relevance to both academia and industry, with the references at the end of each chapter providing a useful starting point for more detailed further reading. Overall, the new English edition of ‘Organic Mechanisms’ is an excellent single reference for those wishing to learn or better understand the complex practice of modern synthetic organic chemistry. It is long overdue and I look forward to having a copy readily available for my students. Margaret Brimble, The University of AucklandHaving held in high regard the 1st English edition of Bruckner´s textbook Organic Reaction Mechanisms I have been waiting for years for an updated version to appear. This long-expected textbook is now available. It has been completely revised and considerably expanded and is a meticulously composed treatise at the interface between synthetic organic chemistry and mechanistic analysis. Every student of advanced organic chemistry will benefit from this book." Koichi Narasaka, Nayang Technical University, Singapore.“This English edition of the German textbook by Bruckner … is an excellent resource for advanced academic students. … The presentation is impressive, and clear illustrations appear throughout the book. … This makes the work a very interesting read and offers abundant opportunities for students to create new problem sets. … For graduate students and instructors, this work offers a wealth of information. The end-of-chapter references are comprehensive and thorough. Summing Up: Highly recommended. Graduate students, researchers/faculty, and professionals.” (S. Rajaraman, Choice, Vol. 48 (3), November, 2010)Table of Contents1 Radical Substitution Reactions at the Saturated C Atom 2 Nucleophilic Substitution Reactions at the Saturated C Atom 3 Electrophilic Additions to the C-C Double Bond 4 ß-Eliminations 5 Substitution Reactions on Aromatic Compounds 6 Nucleophilic Substitution Reactions at the Carboxyl Carbon 7 Carboxylic Compound, Nitriles and Their Mutual Transformation 8 Carbonic Acid Derivatives and Heterocumulenes and their Mutual Transformation 9 Additions of Heteroatom Nucleophiles to Carbonyl Compounds and Subsequent Reactions - Condensaations of Heteroatom Nucleophiles with Carbonyl Compounds 10 Addition of Hydride Donors and Organometallic Compounds to Carbonyl Compounds 11 Conversion of Phosphorus- or Sulfur-Stabilized C Nucleophiles with Carbonyl Compounds: Addition-induced Condensations 12 The Chemistry of Enoles and Enamines 13 Chemistry of the Alkaline Earth Metal Enolates 14 Rearrangements 15 Thermal Cycloadditions 16 Transition Metal-Mediated Alkenylations, Arylations, and Alkynylations 17 Oxidations and Reductions
£87.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Lipid Signaling in Plants
Book SynopsisPhospholipidshavelongbeenknownfortheirkeyroleinmaintainingthebilayer structureofmembranesandinphysicallyseparatingthecytosolfromorganelles andtheextracellularspace. Inthepastdecade,acompletelynovelandunexpected functionemerged,full?llingacrucialroleincellsignaling. Itwasthediscoveryin animalcells,thatagonist-activatedcellsurfacereceptorsledtotheactivationofa phospholipase C (PLC), to hydrolyze the minor lipid, phosphatidylinositol 4- bisphosphateintotwosecondmessengers,inositol1,4,5-trisphosphate(InsP)and 3 2+ diacylglycerol(DAG). WhileInsP diffusesintothecytosol,whereitreleasesCa 3 2+ from an intracellular store by activating a ligand-gated Ca -channel, DAG remainsinthemembranetorecruitandactivatemembersoftheproteinkinase Cfamily. Overtheyears,avarietyofotherlipidbased-signalingcascadesweredisc- ered. Theseinclude,phospholipaseA,generatinglyso-phospholipidsandfreefatty acids(tobeconvertedintoprostaglandinsandleukotrienes),phospholipaseD,to generatethelipidsecondmessenger,phosphatidicacid(PA),andphosphoinositide 3-kinase (PI3K), generating a distinct set of polyphosphoinositides (PPI) ph- phorylated at the D3-position of the inositol ring, all with separate signaling functions. Sphingolipids,representinganotherimportantgroupofsignalinglipids, alsocameacross. Themajorityoftheselipid-basedsignalingpathwayshavebeendiscoveredin plantcellstoo. Moreover,theyhavebeenfoundtobeactivatedinresponsetoa widevarietyofbioticandabioticstresssignals,butalsotobebasicallyinvolvedin plantgrowthanddevelopment. Whilemanyoftheenzymes,lipids,andtheirtargets involved arewell conserved, major differences with the mammalian paradigms havealsoemerged. Thisbookhighlightsthecurrentstatusofplantlipidsignaling. Allchaptershave beenwrittenbyexpertsinthe?eldandcoverinformationforbothbeginnersand advancedlipidologists. PartIincludesphospholipases(Chaps. 1-3),partII,lipid kinases (Chaps. 4-7), part III, lipid phosphatases (Chaps. 8-9), part IV, ix x Preface inositolphosphates and PPI metabolism (Chaps. 10-13), part V, PA signaling (Chaps. 14-17),andpartVI,additionallipidsignals,e. g. oxylipins,NAPEand sphingolipids(Chaps18-20). Ithasbeenagreatpleasuretobetheeditorofthis bookandtobeawitnessofthislipid-signalingadventure. Amsterdam,June2009 TeunMunnik Contents PartI Phospholipases PhospholipaseAinPlantSignalTransduction...3 Gu..ntherF. E. Scherer TheEmergingRolesofPhospholipaseCinPlantGrowth andDevelopment...23 PeterE. DowdandSimonGilroy PlantPhospholipaseD...39 WenhuaZhang,XiaoboWan,YueyunHong,WeiqiLi,andXueminWang PartII Kinases Phosphatidylinositol4-PhosphateisRequiredforTip GrowthinArabidopsisthaliana ...65 AmyL. SzumlanskiandErikNielsen PIP-KinasesasKeyRegulatorsofPlantFunction ...79 TillIschebeckandIngoHeilmann PlantPhosphatidylinositol3-Kinase...95 YureeLee,TeunMunnik,andYoungsookLee DiacylglycerolKinase...107 StevenA. AriszandTeunMunnik xi xii Contents PartIII Phosphatases SignalingandthePolyphosphoinositidePhosphatasesfromPlants ...117 GlendaE. Gillaspy PhosphatidicAcidPhosphatasesinSeedPlants...131 YukiNakamuraandHiroyukiOhta PartIV PPIMetabolism InsP inPlantCells ...145 3 YangJuIm,BrianQPhillippy,andImaraYPerera InositolPolyphosphatesandKinases...161 JillStevenson-PaulikandBrianQ. Phillippy PhosphoinositidesandPlantCellWallSynthesis ...175 RuiqinZhong,RyanL. McCarthy,andZheng-HuaYe ImagingLipidsinLivingPlants ...185 JoopE. M. VermeerandTeunMunnik PartV PASignaling PhosphatidicAcid:AnElectrostatic/Hydrogen-BondSwitch?...2 03 EdgarEduardKooijmanandChristaTesterink NitricOxideandPhosphatidicAcidSignalinginPlants...223 AyelenM. Diste'fano,M. LucianaLanteri,ArjentenHave, CarlosGarc?'a-Mata,LorenzoLamattina,andAnaM. Laxalt 3-Phosphoinositide-DependentProteinKinaseisaSwitchboard fromSignalingLipidstoProteinPhosphorylationCascades...243 ChristineZalejskiandLa'szlo'Bo..gre PartVI AdditionalLipidSignals DiacylglycerolPyrophosphate,ANovelPlantSignalingLipid...263 EmmanuelleJeannette,SophieParadis,andChristineZalejski OxylipinSignalingandPlantGrowth...277 AlinaMosblech,IvoFeussner,andIngoHeilmann Contents xiii FattyAcidAmideHydrolaseandtheMetabolismof N-AcylethanolamineLipidMediatorsinPlants...293 KentD. ChapmanandElisonB. Blanca?or SphingolipidSignalinginPlants...307 LouiseV. MichaelsonandJohnathanA. Napier Index ...323 Contributors Steven A. Arisz Section Plant Physiology, Swammerdam Institute for Life Sciences,UniversityofAmsterdam,SciencePark904,NL-1098XH,Amsterdam, TheNetherlands ElisonB. Blanca?or SamuelRobertsNobleFoundation,PlantBiologyDivision, Ardmore,OK73401,USA,eblanca?or@noble.Table of ContentsPhospholipases.- Phospholipase A in Plant Signal Transduction.- The Emerging Roles of Phospholipase C in Plant Growth and Development.- Plant Phospholipase D.- Kinases.- Phosphatidylinositol 4-Phosphate is Required for Tip Growth in Arabidopsis thaliana.- PIP-Kinases as Key Regulators of Plant Function.- Plant Phosphatidylinositol 3-Kinase.- Diacylglycerol Kinase.- Phosphatases.- Signaling and the Polyphosphoinositide Phosphatases from Plants.- Phosphatidic Acid Phosphatases in Seed Plants.- PPI Metabolism.- InsP3 in Plant Cells.- Inositol Polyphosphates and Kinases.- Phosphoinositides and Plant Cell Wall Synthesis.- Imaging Lipids in Living Plants.- PA Signaling.- Phosphatidic Acid: An Electrostatic/Hydrogen-Bond Switch?.- Nitric Oxide and Phosphatidic Acid Signaling in Plants.- 3-Phosphoinositide-Dependent Protein Kinase is a Switchboard from Signaling Lipids to Protein Phosphorylation Cascades.- Diacylglycerol Pyrophosphate, A Novel Plant Signaling Lipid.- Additional Lipid Signals.- Oxylipin Signaling and Plant Growth.- Fatty Acid Amide Hydrolase and the Metabolism of N-Acylethanolamine Lipid Mediators in Plants.- Sphingolipid Signaling in Plants.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Natural Products: Phytochemistry, Botany and
Book SynopsisThis reference work provides a wealth of information regarding medicinal plants and phytochemicals. It is addressed both to researchers and teachers. The handbook describes phytochemicals, which, by the strictest definition, are chemicals that are produced by plants. During the last decades, more and more groups became actively involved in exploring plants for useful metabolites that lead to the identification of several useful curative agents and many promising molecules to fight and/or prevent diseases, including carcinogenesis and stroke. But when we talk about phytochemicals, there are also medicinal plants where not a single molecule is responsible for the observed properties. This reference work therefore reviews and compiles the information on both these aspects. The volumes contain contributions on phytochemicals and herbal extracts. A large number of natural products obtained from plants and microorganisms is used in cosmetic, drug, flavor and fragrance industries. For this compilation, a range of the most important medicinal herbs and phytochemicals were selected and are described by the recognized authors in the field. The present reference work encompasses the information about well established phytochemicals, biology and biotechnology of medicinal plants or their products, their biosynthesis, novel production strategies, demand and uses, metabolism and bioavailability. There is a surge of information published in recent years on herbal medicine and their pharmacologic effects with single books available on varied subjects. However, all this information is widespread and difficult to overview. Researchers who wish to keep a pace with the rapidly developing field of natural products can now consult this newly compiled handbook to find all information about bioactive molecules and medicinal plants thoroughly compiled in one place!Table of ContentsPart I Alkaloids: General Biology and Biotechnology.- Part II Alkaloids: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part III Alkaloids: Methods of Analysis.- Part IV Alkaloids: Pharmacology.- Part V Phenolics: General Biology and Biotechnology.- Part VI Phenolics: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part VII Phenolics: Methods of Analysis.- Part VIII Phenolics: Biological Activity and Bioavailability.- Part IX Phenolics: Nutraceuticals and Functional Foods.- Part X Terpenes: General Biology and Biotechnology.- Part XI Terpenes: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part XII Terpenes: Methods of Analysis.- Part XIII Terpenes: Pharmacology and Bioavailability.- Part XIV Terpenes: Parapharmaceutical Uses.
£404.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anthropologie: Einführendes Lehrbuch
Book SynopsisAnthropologie, wörtlich übersetzt „die Lehre vom Menschen“, ist eine primär biologische Disziplin – mit vielfältigen kulturwissenschaftlichen Bezügen. In diesem aktuellen Lehrbuch zur Anthropologie reduzieren die Autorinnen deshalb die Biologie des Menschen nicht auf eine Zoologie des Menschen, sondern beziehen seine kulturelle Überformung mit ein. Der Band bietet eine Einführung in die wichtigsten Fragen und ist daher besonders für das Grundstudium geeignet. Für die Neuauflage wurden nahezu alle Kapitel erheblich erweitert und aktualisiert.Trade ReviewAus den Rezensionen zur 1. Auflage:"... kaum ein biologisches Fach hat derart um eine aktualisierte Inhaltsbestimmung ringen müssen wie die Anthropologie … Nun haben vier Autorinnen … endlich diese schon längst empfundene Notwendigkeit erfüllt ... Hervorzuheben ist von Anfang an, dass die Fülle der neuen Methoden ... ganz selbstverständlich eingebaut ist … Alles in Allem erscheint der Band trotz der vier Autoren wie aus einem Guss … Man gewinnt ... den erfreulichen Eindruck, dass in dem schwer angeschlagenen Fach doch ein ganz erhebliches Innovationspotential steckt. Dem ... Buch ist ... eine weite Verbreitung zu wünschen! …" (H. Preuschoft, in: Zentralblatt für Geologie und Paläontologie Teil II, 2008, Issue 1-2, S. 115 ff.)Table of ContentsEinleitung.- Evolution der Menschen.- Bevölkerungsbiologie.- Lebenszyklus.- Angewandte Anthropologie.- Verhaltensbiologie.- Literaturverzeichnis.- Sachverzeichnis.
£44.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Springer Handbook of Marine Biotechnology
Book SynopsisThis Springer Handbook provides, for the first time, a complete and consistent overview over the methods, applications, and products in the field of marine biotechnology. A large portion of the surface of the earth (ca. 70%) is covered by the oceans. More than 80% of the living organisms on the earth are found in aquatic ecosystems. The aquatic systems thus constitute a rich reservoir for various chemical materials and (bio-)chemical processes.Edited by a renowned expert with a longstanding experience, and including over 60 contributions from leading international scientists, the Springer Handbook of Marine Biotechnology is a major authoritative desk reference for everyone interested or working in the field of marine biotechnology and bioprocessing - from undergraduate and graduate students, over scientists and teachers, to professionals.Marine biotechnology is concerned with the study of biochemical materials and processes from marine sources, that play a vital role in the isolation of novel drugs, and to bring them to industrial and pharmaceutical development. Today, a multitude of bioprocess techniques is employed to isolate and produce marine natural compounds, novel biomaterials, or proteins and enzymes from marine organisms, and to bring them to applications as pharmaceuticals, cosmeceuticals or nutraceuticals, or for the production of bioenergy from marine sources. All these topics are addressed by the Springer Handbook of Marine Biotechnology.The book is divided into ten parts. Each part is consistently organized, so that the handbook provides a sound introduction to marine biotechnology - from historical backgrounds and the fundamentals, over the description of the methods and technology, to their applications - but it can also be used as a reference work.Key topics include: - Marine flora and fauna - Tools and methods in marine biotechnology - Marine genomics - Marine microbiology - Bioenergy and biofuels - Marine bioproducts in industrial applications - Marine bioproducts in medical and pharmaceutical applications - and many more...Trade Review“Marine Biotech‘s key aims is ‘to be useful as readable desk reference book to give a fast and comprehensive overview and easy retrieval of essential reliable key information, including tables, graphs, and bibliographies.’ … It is therefore important to have books such as Marine Biotech to present the drawing together of information about specific research to give the non-specialist that necessary topical overview and updating.” (Nigel Chaffey, Annals of Botany, aobblog.com, April, 2016)Table of ContentsPart A Marine Flora and FaunaMarine Fungal Diversity.- Diversity of Marine Phototrophs.-Marine Viruses.- Marine Microalgae.- Seaweed Flora of the European North Atlantic.- Corals.- Marine Sponges - Molecular Biology and BiotechnologyPart B Tools and MethodsBioprocess Engineering of Phototrophic Marine Organism.- Bioinformatic Techniques in Marine Genomics.- Bioprospection of Marine Microorganisms.- Cultures of Marine Microorganisms.- Transgenic Technology in Marine Organisms.- Marine Enzymes.- Quorum Sensing and Quenching.- Detection of Invasive SpeciesPart C GenomicsMarine Metagenomics.- Proteomics in Marine Biotechnology.- Marine Metagenome.- Microfluidic Systems.- Genome MiningPart D Algal TechnologySulphated Algal Polysaccharides.- Iodine in Seaweeds - Research History.- Marine Macrophytes.- Removal of Heavy MetalsPart E Microbiology and BiotechnologyMicrobial Biotechnology.- Actinomycetes in Biodiscovery.- Biotransformation of NitrilesPart F Derived MetabolitesMarine Natural Products.- Biocatalysts from Aplysia.- Anti-Microbial Peptides.- Fungal Metabolites.- Dinoflagellates-Associated Human Poisoning.- Carotenoids Derived from Seaweeds.- Cnidarians - Bioactive Compounds.- Lipids from Tropical Marine Sponges.- Marine Biotoxins.- Microbial Enzymes.- Polysaccharides from Marine OrganismsPart G Applications of Marine BiotechnologyPharmaceuticals.- Functional Food.- Nutraceuticals.- Cosmeceuticals.- Fatty Acids.- Selenium-Containing Antioxidant Selenoneine.- Alginate Oigosaccharides.- Plant Pest ManagementPart H Bioenergy and BiofuelsBlue Biotechnology for Marine Bioenergy.- Marine Algal Biotechnology and Bioenergy.- Marine Bioenergy and Biofuels.- Antifouling Materials for Water TreatmentPart I Biomedical ApplicationsMarine Biomaterials.-Gene Delivery.- Marine Microorganisms in Nanoparticles.- Therapeutics and Medical Diagnostics.- Biosensors.- BiomineralizationPart J Industrial ApplicationsFunctional Feeds in Aquaculture.- Mussel-Derived Bioadhesives.- Marine Silicon Biotechnology.- Microalgal Biotechnology.- Biofouling and BiocorrosionSubject Index.- Acknowledgements.- About the Authors
£251.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Personalbedarf und Kosten im medizinischen
Book SynopsisDieses Buch gibt dem Labor- und Verwaltungsleiter im Bereich der Labororganisation für die Personalbedarfsberechnung, die Kostenstellenrechnung und Kosten-Nutzen-Beurteilung und die Führung einer Laborstatistik wertvolle Hilfestellung und Anregung. Die 3., verbesserte und erweiterte Neuauflage des erstmals 1976 als Band 1 der INSTAND-Schriftenreihe erschienenen Buches enthält zusätzlich ein Kapitel zur Kostenermittlung und - aus aktuellem Anlaß - ein neues Kapitel über deskriptive Laborstatistik. Das Buch faßt somit alle bekannten Verfahren zur Personalbedarfsberechnung und zur Kostenermittlung im Medizinischen Laboratorium zusammen und ist als Anleitung zur selbständigen Durchführung dieser Berechnungen gedacht. Das Buch will ausreichend Hilfe und Anregung geben, Probleme der Laborleitung im Bereich Organisation, Laborstatistik, Personalbedarfsberechung, Kostenstellenrechnung und Kosten-Nutzen-Analysen zu lösen.Table of Contents1 Einleitung.- 2 Arbeitszeitermittlungsverfahren und Flexible Berechnung Des Personalbedarfs In Klinischen Laboratorien.- 2.1 Wozu Arbeitszeitermittlungen in Krankenhauslaboratorien?.- 2.2 Einzelne Arbeitszeitermittlungsverfahren für Klinische Laboratorien.- 2.2.1 Vorbereitende Überlegungen.- 2.2.1.1 Ziel der Arbeitszeitanalyse.- 2.2.1.2 Die Bezugsgröße: Meßbare Leistungseinheiten.- 2.2.1.3 Strukturierung und Abgrenzung von Tätigkeiten.- 2.2.2 Schätzen von Arbeitszeiten.- 2.2.3 Verfahren der Selbstaufzeichnung.- 2.2.4 Arbeitsplatzstudie (Fremdbeobachtung).- 2.2.4.1 Auswertung der Arbeltszeitstudie.- 2.2.4.2 Berücksichtigung des Leistungsgrades (qualitative Komponente der Personalausstattung).- 2.2.5 Multimomenthäufigkeitsverfahren.- 2.2.6 Systeme vorbestimmter Zeiten — weitere Ansätze zur Arbeitszeitermittlung in Laboratorien.- 2.3 Arbeitszeitermittlung — Ist-Analyse und Sollkonzeption.- 2.3.1 Berechnung einer Soll-Tätigkeitsverteilung.- 2.3.2 Berechnung des Soll-Arbeitszeitbedarfs.- 2.4 Resümee.- 3 Bewertungssystem Zur Ermittlung Des Personalbedarfs Im Medizinischen Laboratorium.- 3. 1 Einführung.- 3.2 Begriffe.- 3.2.1 Jahresstatistik.- 3.2.1.1 Erfassung zur Jahresstatistik.- 3.2.1.2 Erfassungsbogen.- 3.2.2 Analyse.- 3.2.2.1 Primäranalyse.- 3.2.2.2 Hilfsanalysen.- 3.2.2.3 Standard.- 3.2.2.4 Kontrollproben.- 3.2.2.5 Ringversuchsproben.- 3.2.3 Profil.- 3.2.4 Mehrkanalige, selektive Analysengeräte.- 3.2.5 Laborarbeitsschicht.- 3.2.6 Arbeitsminuten je Jahr.- 3.3 Grundlage des Bewertungssystems.- 3.4 Grundeinstufung.- 3.5 Bewertungstabelle.- 3.6 Mechanisierungsstufen.- 3. 7 Durchführung der Berechnung.- 3.7.1 Laboratoriumstechnisches Personal.- 3.7.1.1 Untersuchungszahlenabhängiges Personal.- 3.7.1.2 Untersuchungszahlenunabhängiges Personal.- 3.7.1.3 Personal außerhalb der regulären Arbeitszeit.- 3.7.1.4 Notfall-Laboratorium.- 3.7.1.5 Zuordnung des Technischen Personals.- 3.7.2 Personal mit Hochschulbildung.- 3.7.3 Verwaltungspersonal.- 3.7.4 Personal im Reinigungsdienst.- 3.7.5 Neueinrichtung eines Laboratoriums.- 3.8 Liste der Grundeinstufungen.- 3.9 Liste der Mechanisierungsstufen.- 3.10 Muster der Berechnungsbögen.- 4 Eine Methode zur Erstellung Eines Personalplanes im Klinischen Laboratorium.- 4. 1 Einleitung.- 4.2 Begriffe.- 4.2.1 Zählobjekte.- 4.2.1.1 Angeforderte Analysen.- 4.2.1.2 Durchgeführte Analysen.- 4.2.1.3 Mitgeteilte Analysenergebnisse.- 4.2.2 Zeitbegriff.- 4.2.2.1 Spezimenzeit.- 4.2.2.2 Personalzeiten.- 4.2.2.3 Arbeitszeiten.- 4.3 Grundlagen des Systems.- 4.3.1 Leistungseinheitsrechnung.- 4.3.2 Arbeitsplatzberechnung.- 4.4 Berechnung der variablen und fixen Bearbei-tungs-bzw. direkten Personalzeit.- 4.5 Bewertungszahl.- 4.5.1 Bewertungszahl für das technische und administrative Personal “B”.- 4.5.2 Bewertungszahl für das Reinigungspersonal “B”.- 4.5.2.1 Reinigungsfläche.- 4.5.2.2 Geräte- und Glasreinigung.- 4.6 Zuschlagkoeffizient.- 4.6.1 Zuschlagkoeffizient für nicht quantifizierbare Tätigkeiten.- 4.6.2 Mehrdienstleistungskoeffizient.- 4. 7 Turnusdienst.- 4.8 Berechnung des Technischen Personals.- 4.9 Berechnung des Reinigungspersonals.- 4.9. 1 Personal für die Flächenreinigung.- 4.9.2 Personal für die Reinigung wiederverwendbarer Gerätschaften.- 4.10 Berechnung des Personalplanes.- 4.11 Besonderheiten.- 4.11.1 Überleitung zu Punktesystemen.- 4.11.2 Selektiv arbeitende Mehrkanalgeräte.- 4.11.3 Durchsatzraten von mechanisierten Systemen.- 4.12 Schnittstellen zur Geräteauslastung und Investitionsplanung, Kostenkalkulation.- 5 Cap Workload Recording Method.- 5.1 Vorgeschichte.- 5.2 Einführung in die CAP-Methode.- 5.3 Der Aufbau eines user procedure file.- 5.4 Beispiele.- 5.5 Berechnung der workload.- 5.6 Der Einfluß mechanisierter Analysentechnik auf unit value und workload.- 5.7 Kritische Betrachtung.- 5.8 CAP-Zeitstudien.- 5.9 CAP-Methode als Management-Instrument.- 6 Ist-Aufnahme, Kostenermittlung u. Ist-Analyse.- 6.1 Einleitung.- 6.1.1 Allgemeines.- 6.1.2 Zweck.- 6.1.3 Begriffe.- 6.1.4 Geltungsbereich.- 6.2 Datensammlung zur Ist-Aufnahme.- 6.2.1 Allgemeines.- 6.2.2 Vorarbeiten.- 6.2.2.1 Bauplan, Raumverzeichnis u. Arbeitsbereiche.- 6.2.2.2 Inventar, Flächenbedarf, Brauchbarkeitsdauer u. Abschreibung.- 6.2.2.3 Raumkosten.- 6.2.2.4 Energiekosten.- 6.2.2.5 Stellenplan.- 6.2.2.6 Verbrauchsmaterial- u. Instandhaltekosten.- 6.2.3 Einrichtung der Arbeitsgruppen.- 6.2.3.1 Aufgaben der Statistikgruppe.- 6.2.3.2 Aufgaben der Datengruppe.- 6.2.3.3 Aufgaben der Kostengruppe.- 6.3 Beschreibung des Ist-Zustandes.- 6.3.1 Geltungsbereich.- 6.3.1.1 Laboratorium.- 6.3.1.2 Umfeld.- 6.3.1.3 Zeitraum.- 6.3.2 Umfeld des Labors.- 6.3.2.1 Beschreibung des Gesamtbetriebes.- 6.3.2.2 Bereich des Gesamtbetriebes.- 6.3.3 Laborbeschreibung.- 6.3.4 Laboraufwand.- 6.3.4.1 Räumlichkeiten.- 6.3.4.2 Personal.- 6.3.4.3 Inventar.- 6.3.4.4. Wartung u. Pflege.- 6.3.4.5 Verbrauchsmaterial.- 6.3.4.6 Energie u. Wasser.- 6.3.4.7 Sonstiges.- 6.3.5 Labororganisation.- 6.3.5.1 Personalmanagement.- 6.3.5.2 Sicherheitswesen.- 6.3.5.3 Beschaffungswesen u. Lagerhaltung.- 6.3.5.4 Spezimengewinnung u. Transportwesen.- 6.3.5.5 Verteilung.- 6.3.5.6 Methodologie.- 6.3.5.7 Arbeitsplatzpflege.- 6.3.5.8 Qualitätssicherungsmaßnahmen.- 6.3.5.9 Ergebnis u. Befunderstellung.- 6.3.5.10 Rechnungswesen.- 6.3.5.11 Dokumentation u. Archivierung.- 6.3.5.12 Sonstiges.- 6.3.6 Laborleistungen.- 6.3.6.1 Zeitunkritischer Leistungskatalog.- 6.3.6.2 Semizeitkritischer Leistungskatalog.- 6.3.6.3 Zeitkritischer Leistungskatalog.- 6.3.6.4 Befundungen, Konsiliarleistungen.- 6.3.6.5 Patientenversorgung.- 6.3.6.6 Fremdanalysen.- 6.3.6.7 Leistungserfassung.- 6.3.6.8 Sonstiges.- 6.3.7 Kostenermittlung.- 6.3.7.1 Allgemeines.- 6.3.7.2 Fixe Kosten u. Betriebskosten.- 6.3.7.3 Sprungfixe Personalkosten.- 6.3.7.4 Variable Kosten.- 6.3.7.5 Gesamtkosten.- 6.3.7.6 Vereinfachte Kostenrechnung (Durchschn. kosten).- 6.3.8 Laborerträge.- 6.3.9 Sonstiges.- 6.4 Ist-Analyse.- 6.4.1 Vorgaben zur Ist-Analyse.- 6.4.2 Durchführung der Ist-Analyse.- 6.4.3 Konsequenzen der Ist-Analyse.- 7 Struktur- u. Wirtschaftlichkeits-Analyse im Medizinischen Laboratorium.- 7.1 Notwendigkeit von Wirtschaftlichkeitsuntersuchungen.- 7.2 Die Problematik von Wirtschaftlichkeitsuntersuchungen im medizinischen Labor.- 7.2.1 Grundsätzliche strukturelle Probleme.- 7.2.2 Die Problematik der Kostenstruktur.- 7.2.3 Problematik der Erlösstruktur.- 7.2.4 Schwachstellen im Rechnungswesen.- 7.2.5 Betriebswirtschaftliches Know-How-Defizit u. mangelndes Kostenbewußtsein.- 7.3 Struktur—Analyse als Voraussetzung für Wirtschaftlichkeitsuntersuchungen.- 7.4 Die integrierte Struktur- u. Wirtschaftlichkeits-Analyse als praktikable Problemlösung.- 7.4.1 Anforderungen u. Ziele.- 7.4.2 Computerunterstützung.- 7.4.3 Betriebswirtschaftliche Methodik.- 7.4.4 Formularsystem zur Ist-Analyse.- 7.5 Module u. Auswertungen aus der Struktur. u. Wirtschaftlichkeitsanalyse.- 7.5.1 Mehrjahres-Entwicklung.- 7.5.2 Struktur-analyse.- 7.5.3 Kosten- u. Leistungsrechnung.- 7.6 Vorgehensweise, Zeitbedarf.- 7.7 Erkenntnisse, Vorteile, Nutzen.- 7.8 Planung u. Realisierung neuer Laborkonzeptionen.- 7.9 Grundlagen, Ausgangspunkt zur permanenten Wirtschaftlichkeitsüberwachung (Controlling).- 7. 10 Zusammenfassung.- 8 Deskriptive Laborstatistik.- 8. 1 Einleitung.- 8.2 Fragestellungen.- 8.2.1 Fragestellungen der Antragsstatistik.- 8.2.2 Fragestellungen der Eingangsstatistik.- 8.2.3 Fragestellungen der Leistungsstatistik.- 8.2.4 Fragestellungen der Ergebnisstatistik.- 8.3 Systematik der gegenseitigen Zuordnung von Analysen und Ergebnissen.- 8.4 Tabelle der Zählregeln.- 8.5 Datenerfassung.- 8.5.1 Manuelle Statistikführung.- 8.5.2 Maschinelle Datenerfassung.- 8.6 Anhang.- 8.6.1 Zählobjekte.- 8.6.2 Zählperioden.- 8.6.3 Erfassungseinheiten.- Sachregister/Stichwortverzeichnis.
£46.74
Springer Gluten Sensitivity: About Gluten-Associated
Book SynopsisGluten sensitivity is a multifactorial phenomenon. In the medical context, it is associated with symptoms that occur after the consumption of gluten-containing foods. However, not all cases of perceived gluten sensitivity are medically diagnosable. Only for celiac disease and wheat allergies clear diagnostic criteria exist. In most cases patients have non-Celiac Non-Wheat Allergy Wheat Sensitivity (NCWS). Gluten can rarely be detected as a causative agent in NCWS. Rather, other ingredients of wheat, such as ATI or FODMAP, or a disturbed intestinal microbiota may be considered as triggers for the disease. Cordula Harter puts it straight: gluten sensitivity is a fashion trend that is followed by many more people than there are diagnosed patients. The author shows that gluten-containing cereals are nutritionally high-quality foods that provide valuable nutrients and fiber. Elimination is rarely medically indicated and often benefits the food industry more than the consumer. This Springer essential is a translation of the original German 1st edition essentials, Gluten-Sensitivität by Cordula Harter, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Table of ContentsGluten and wheat.- The role of intestinal health.- Diseases associated with gluten intolerance.- Gluten in the diet.- Gluten free as a trend.
£999.99
LAP Lambert Academic Publishing Newcastle Disease Virus
Book Synopsis
£36.46
Springer Fachmedien Wiesbaden Reaktionsmechanismen: Organische Reaktionen,
Book SynopsisMechanistische Überlegungen nehmen heute einen festen Platz in der Organischen Chemie ein: Welche Faktoren beeinflussen die Reaktivität eines Moleküls? Welche typischen Reaktionsprinzipien und -muster gibt es, und in welchen Schritten verlaufen organisch-chemische Reaktionen? Wie lassen sich Reaktionen steuern? Anhand moderner und präparativ nützlicher Reaktionen erläutert der Autor die Reaktionsprinzipien; klar und verständlich werden Konzepte herausgearbeitet, stets auch stereochemische Konsequenzen abgeleitet. Der Autor bietet Faustregeln zur Reaktivitätsabschätzung sowie Tips und Tricks für die Praxis. Die zweifarbige Gestaltung erhöht die Übersichtlichkeit und erleichtert das Verfolgen der Mechanismen. In der vorliegenden 3. Auflage wurden nach dem überwältigenden Verkaufserfolg der 2. Auflage die Fehler in Text und Grafiken korrigiert und die Literatur nochmals aktualisiert. Der Index eignet sich nun für eine detaillierte Stichwortsuche.Table of ContentsRadikalische Substitutionsreaktionen am gesättigten C-Atom.- Nucleophile Substitutionsreaktionen am gesättigten C-Atom.- Additionen an die olefinische C=C-Doppelbindung.- beta-Eliminierungen.- Substitutionsreaktionen an Aromaten.- Nucleophile Substitutionsreaktionen (außer durch Enolate) am Carboxyl-Kohlenstoff.- Carboxylverbindungen und Nitrile und deren Umwandlung ineinander.- Kohlensäurederivate und Heterocumulene und deren Umwandlung ineinander.- Additionen von Heteroatom-Nucleophilen an Carbonylverbindungen und Folgereaktionen - Kondensationen von Heteroatom-Nucleophilen mit Carbonylverbindungen.- Addition von H-Nucleophilen und von Metallorganylen an Carbonylverbindungen.- Umsetzung von Phosphor- oder Schwefel-stabilisierten C-Nucleophilen mit C-Carbonylverbindungen: durch Additionen eingeleitete Kondensationen.- Chemie der Enole und Enamine.- Chemie der Alkalimetall-Enolate.- Umlagerungen.- Thermische Cycloadditionen.- Übergangsmetall-vermittelte Alkenylierungen, Arylierungen und Alkinylierungen.- Oxidationen und Reduktionen.- Index.
£999.99
Springer Fachmedien Wiesbaden Der Experimentator: Proteinbiochemie/Proteomics
Book SynopsisDie überarbeitete und aktualisierte 7. Auflage dieses Buches gibt einen Überblick über bewährte und neue Methoden der Proteinbiochemie und Proteomics. Es zeigt Auswege aus experimentellen und strategischen Sackgassen. Zudem weckt es ein Gespür für das richtige Experiment zur richtigen Zeit. Behandelt werden klassische Verfahren wie Säulenchromatographie, HPLC, Elektrophoresen, Blots, ELISA, Ligandenbindungstests, die Herstellung von Antikörpern, das Solubilisieren von Membranproteinen, die Analyse von Glykoproteinen usw. Einen großen Raum nehmen die modernen Verfahren ein: Massenspektrometrie, Proteomics und thermische Analyse. In die 7. Auflage wurden neue Techniken zur Bestimmung der Wechselwirkung von Proteinen mit Proteinen oder von Proteinen mit kleinen Molekülen aufgenommen: DARTS, DRACALA, SPROX und andere. Des weiteren erfahren Sie, wie man mit dem Massenspektrometer eine Bindung misst. Auch Methoden zur Herstellung von Bindungsproteinen gegen bestimmte Zielmoleküle werden vorgestellt: Ribosomen Display und DNA- und Peptid-Aptamer-Techniken. Der Fluoreszenznachweis von Proteinen mit Hilfe von Trihalogenverbindungen durfte nicht fehlen und wer die Stabilität und Faltung von Proteinen messen will, kann hier nachlesen, ob er dazu ein CD-Spektrometer benutzen sollte. Auf die Fortschritte in der HPLC und der Massenspektrometrie von Membranproteinen wird ebenso eingegangen wie auf ihre Rekonstitution in Nanoscheibchen (Nanodiscs). Die Mikrodissektion mit UV-Laser, die isoelektrische Fokussierung in Kapillaren und iTRAQ-Tags werden erklärt. Dazu kommt eine Anzahl neuer Tricks zur Proteinbestimmung, Gelfärbung, Blottechnik, Immunfärbung, Elution aus Gelstückchen etc.Table of ContentsDas tägliche Brot.- Ligandenbindung.- Membranproteine solubilisieren.- Rekonstitution von Proteinen.- Säubern und Putzen.- Antikörper.- Proteomics.- Untereinheiten.- Glykoproteine.- Der Schatz im Silbersee.- Durch die Wüste
£26.59
Springer Fachmedien Wiesbaden Biochemie: Eine Einführung für Mediziner und
Book SynopsisDie 3., korrigierte Auflage der bewährten Einführung in die Biochemie präsentiert erneut die Schlüsselkonzepte des Faches in verständlicher Form - kompakt, anschaulich, didaktisch durchdacht. Das bestens eingeführte Lehrbuch richtet sich an Studierende der Medizin, Biologie und Chemie, die einen fundierten und leicht zugänglichen Überblick über das Gesamtgebiet der Biochemie suchen, ohne in der Fülle der modernen biochemisch-molekularbiologischen Erkenntnisse den Boden unter den Füßen zu verlieren. Dem Autor gelingt es, die Grundlagen, Leitmotive und Schlüsselkonzepte der Biochemie herauszuarbeiten und dem Leser somit das Rüstzeug für erfolgreiche Prüfungen wie auch für die spätere Vertiefung in die weiterführende Literatur zu liefern. Konzeptionell durchdacht vermittelt das Buch in fünf Teilen I: Molekulare Architektur des Lebens II: Struktur und Funktion von Proteinen III: Speicherung und Ausprägung von Erbinformation IV: Signaltr ansduktion und zelluläre FunktionV: Energiewandlung und Biosynthesenicht nur das Grundwissen der Biochemie, sondern veranschaulicht auch das Gedankengebäude dieser dynamischen Disziplin. Schlüsselbegriffe und wichtige Biomoleküle sind im Text hervorgehoben. Eine Fülle von Querverweisen schafft Zusammenhänge zwischen den Abschnitten und Kapiteln. Ausformulierte Zwischenüberschriften können als Merksätze zur schnellen Rekapitulation dienen. Maus-Symbole verweisen auf Websites, die in einer umfangreichen Link-Sammlung im Internet zur Verfügung stehen und weiterführende Informationen zu einzelnen Themen liefern. Zahlreiche Exkurse werfen Schlaglichter auf interessante biochemische und pathobiochemische Phänomene - ob es sich um die molekulare Basis menschlicher Krankheiten, wichtige Untersuchungsmethoden, spezielle Molekülstrukturen oder zellbiologische Prozesse handelt. Zur schnellen Orientierung sind die wichtigsten Biomoleküle nach Gruppen geordnet auf 15 ganzseitigen Tafeln dargestellt sowie sämtliche im Buch aufgeführten Hormone mit ihren Rezeptoren und Signalwegen als kompakte Übersicht im Tafelteil präsentiert.Eine Besonderheit des Buches sind die mehr als tausend Grafiken, die eine unverwechselbare Handschrift - plakativ, klar, verständlich - tragen und in dichter Folge die im Text vorgestellten Phänomene und Prozesse veranschaulichen.Die vorgegebenen Ausbildungsinhalte für Mediziner in der Biochemie sind durch das Buch nahezu vollständig abgedeckt. Auch das - in der neuen Approbationsordnung betonte - Zusammenwachsen von Biochemie und Molekularbiologie spiegelt sich im Buch wider.Mit diesem klar gegliederten und verständlich geschriebenen Lehrbuch macht es einfach Spaß, Biochemie zu lernen!Table of ContentsTeil I: Molekulare Architektur des Lebens1. Chemie - Basis des Lebens2. Biomoleküle - Bausteine des Lebens3. Zellen - Organisation des LebensTeil II: Struktur und Funktion von Proteinen4. Proteine - Werkzeuge der Zelle5. Ebenen der Proteinarchitektur6. Proteine auf dem Prüfstand7. Erforschung der Proteinstruktur8. Proteine als Strukturträger9. Proteine als molekulare Motoren10. Dynamik sauerstoffbindender Proteine11. Proteine als molekulare Katalysatoren12. Mechanismen der Katalyse13. Regulation der Enzymaktivität14. Enzymkaskaden des Bluts15. Evolution der ProteineTeil III: Speicherung und Ausprägung von Erbinformation16. Nucleinsäuren - Struktur und Organisation17. Transkription - Umschrift genetischer Information18. Translation - Decodierung genetischer Information19. Posttranslationale Prozessierung und Sortierung von Proteinen20. Kontrolle der Genexpression21. Replikation - Kopieren genetischer Information22. Analyse und Manipulation von Nucleinsäuren23. Veränderung genetischer InformationTeil IV: Signaltransduktion und zelluläre Funktion24. Struktur und Dynamik biologischer Membranen25. Proteine als Funktionsträger von Biomembranen26. Ionenpumpen und Membrankanäle27. Prinzipien der interzellulären Kommunikation 28. Signaltransduktion über G-Protein-gekoppelte Rezeptoren29. Signaltransduktion über enzymgekoppelte Rezeptoren30. Hormonelle Steuerung komplexer Systeme31. Molekulare Physiologie des Gastrointestinaltrakts32. Neuronale Erregung und Transmission33. Struktur und Dynamik des Cytoskeletts34. Zellzyklus und programmierter Zelltod35. Molekulare Basis von Krebsentstehung und Krebsbekämpfung36. Angeborenes und erworbenes Immunsystem37. Erforschung und Entwicklung neuer ArzneistoffeTeil V: Energiewandlung und Biosynthese38. Grundprinzipien des Metabolismus39. Glykolyse - Prototyp eines Stoffwechselwegs40. Citratzyklus - zentrale Drehscheibe des Metabolismus41. Oxidative Phosphorylierung - Elektronentransport und ATP-Synthese42. Pentosephosphatweg - ein adaptives Stoffwechselmodul43. Gluconeogenese und Cori-Zyklus44. Biosynthese und Abbau von Glykogen45. Fettsäuresynthese und ß-Oxidation46. Biosynthese von Cholesterin, Steroiden und Membranlipiden47. Abbau von Aminosäuren und Harnstoffzyklus48. Biosynthese von Aminosäuren und Häm49. Bereitstellung und Verwertung von Nucleotiden50. Koordination und Integration des Stoffwechsels
£49.49
Springer Fachmedien Wiesbaden Hormone und Hormonsystem - Lehrbuch der
Book SynopsisDie technischen Fortschritte und neuen Möglichkeiten der molekularen Biologie – Genomanalysen, Expressionsanalysen, konfokale Lasermikroskopie, Proteomics – lassen die Physiologie von Wirbeltieren, genauso wie die von Nicht-Wirbeltieren, in einem neuen Licht erscheinen. Bei der Darstellung der Endokrinologie von Mensch und Tier wird dieser Entwicklung Rechnung getragen: Die Schwerpunkte liegen auf Hormonbiochemie, Hormonphysiologie, Hormonrezeptoren, endokrinen Organen und Regelkreisen und der Regelung endokriner Rhythmen. Die Betrachtung des Hormonsystems reicht von seinen Ursprüngen bei Invertebraten, seiner Evolution, den Wechselwirkungen mit Nerven- oder Immunsystem bis zu Stoffwechselstörungen bei menschlichen Gen-Defekten. Die 4. Auflage ist deutlich erweitert. Das Thema Stoffwechsel nimmt, verteilt über mehrere Kapitel, eine wesentlich größeren Raum ein. Komplett neu ist auch die Embryologie der endokrinen Organe.Trade Review“... Zusammenfassend handelt es sich beim „Kleine/Rossmanith" um ein kompaktes Lehrbuch, das die wesentlichen Bereiche der Endokrinologie abdeckt und für den Einstieg in dieses spannende Fach zu empfehlen ist.” (Jan Tuckermann, in: BIOspektrum, Jg. 28, Heft 4, 2022) “… Das Buch stellt eine immense Fleißarbeit dar, alleine die bei den einzelnen' Kapiteln angeführten Literaturverzeichnisse haben einen Umfang, den man in den üblichen Lehrbüchern nur noch selten findet. Das macht dieses Lehrbuch aber zu einem nützlichen Nachschlagewerk für jeden, der sich über spezielle Probleme der Endokrinologie auch unter evolutionären und vergleichenden Aspekten informieren will.” (Prof. Dr. L. Wildt, in: Der Gynäkologe, Heft 8, August 2021)Table of ContentsEinführung.- Zur Geschichte der Endokrinologie.- Hormone – eine Definition.- Protein- und Peptid-Hormone von Vertebraten.- Protein- und Peptide-Hormone von Invertebraten.- Juvenil- and Steroid-Hormone.- Produkte von Aminosäuren.- Hormonrezeptoren.- Bildung, Freisetzung und Wirkung.- Organe des Hormonsystems.- Regulationsmuster.- Endokrine Musik: Sekretionsrhythmen.- Evolution der Hormonbildung.- Krankheiten des endokrinen Systems.-Leistungssteigerung – legal und Illegal.- Anhang.
£47.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Löffler/Petrides Biochemie und Pathobiochemie
Book SynopsisJetzt kommt Bewegung in die Biochemie!Die ganze Welt der Biochemie und Pathobiochemie in 74 überschaubaren Kapiteln und über 1000 Abbildungen erklärt – da bleibt keine Frage offen.Und mehr noch, damit Sie die komplexen Vorgänge in Stoffwechsel, Signaltransduktion und Molekularbiologie schneller verstehen, sind mit der kostenlosen MoreMediaApp fast 400, teils vertonte Videos direkt aus dem Buch abrufbar – einfach das Bild mit dem Smartphone oder Tablet scannen und schon werden Citratzyklus, DNA-Replikation und Co. lebendig! So lässt sich auch später in der Klinik schnell etwas wiederholen – Film ab und das biochemische Hintergrundwissen ist aufgefrischt.Außerdem bietet die Biochemie und Pathobiochemie: 74 überschaubare Kapitel für einen guten Überblick Auflistung der Schwerpunkte am Kapitelanfang Einen Roten Faden, der kleine Abschnitte kurz zusammenfasst Zusammenfassungen am Kapitelende Tafelteil mit den wichtigsten Strukturformeln zum Nachschlagen Wie wichtig das Wissen über Moleküle, Mechanismen und Signalwege für das Verständnis pathologischer Vorgänge ist, wird anhand zahlreicher spezieller Abschnitte oder eigener Kapitel zur Pathobiochemie herausgestellt. Schließlich geben spannende Exkurse und Hintergrundinfos einen Blick über den Tellerrand oder weiter in die Tiefe.Biochemie ausführlich und animiert – Ihr Begleiter durchs ganze Studium!Table of ContentsI Grundlagen der Biochemie und Molekulären Zellbiologie: Ohne Wasser kein Leben.- Vom Molekül zum Organismus.- Kohlenhydrate, Lipide, Aminosäuren und Nucleotide - Bausteine des Lebens,mitTafelteil.- Thermodynamik und Bioenergetik.- Proteine - Struktur und Funktion.- Proteine – Analytische Untersuchungsmethoden, Synthese und Isolierung.- Enzyme - Molekulare und funktionelle Grundlagen der Biokatalyse.- Regulation der Enzymaktivität.- Enzyme in Analytik, Diagnoste und Therapie.- Nucleinsäuren - Struktur und Funktion.- Biokatalyse.- Zellorganellen und Vesikeltransport. Cytoskelett.-II Zellulärer Metabolismus: Glucose – Schlüsselmolekül des Kohlenhydratstoffwechsels.- Mechanismen der Glucosehomöostase.- Zucker - Bausteine von Glycoproteinen und Heteroglycanen.- Pathobiochemie des Kohlenhydratstoffwechsels.- Der Citratzyklus – Abbau von Acetyl-CoA zu CO2 und H2O.- Mitochondrien – Organellen der ATP-Gewinnung.- Oxidoreduktasen und reaktive Sauerstoffspezies.- Lipogenese und Lipolyse - Bildung und Verwertung der Fettspeicher.- Stoffwechsel von Phosphoglyceriden und Sphingolipiden.- Stoffwechsel von Cholesterin.- Lipoproteine - Transportformen der Lipide im Blut.- Pathobiochemie des Lipidstoffwechsels.- Prinzipien von Aminosäurestoffwechsel und Stickstoffumsatz.- Funktioneller Aminosäurestoffwechsel.- Pathobiochemie des Aminosäurestoffwechsels.- Purinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pyrimidinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pathobiochemie des Purin- und Pyrimidinstoffwechsels.- Porphyrine - Synthese und Abbau.- III Zelluläre Kommunikation: Prinzipien zellulärer Kommunikation.- Mediatoren.- Rezeptoren und ihre Signaltransduktion.- Insulin - das wichtigste anabole Hormon.- Glucagon und Katecholamine - Gegenspieler des Insulins.- Integration und hormonelle Regulation des Energiestoffwechsels.- Hormone des Hypothalamus und der Hypophyse.- Steroidhormone – Produkte von Nebennierenrinde und Keimdrüsen.- Schilddrüsenhormone – Zentrale Regulatoren von Entwicklung, Wachstum, Grundumsatz, Stoffwechsel und Zelldifferenzierung.- Wachstumshormon und Prolactin.- IV Molekularbiologie: Zellzyklus – Koordination der Zellteilung.- Replikation –Die Verdopplung der DNA.- DNA-Mutationen und ihre Reparatur.- Transkription und Prozessierung von RNA.- Regulation der Transkription – Aktivierung und Inaktivierung der Genexpression.-Translation – Synthese von Proteinen.- Proteine - Transport, Modifikation und Faltung.- Proteine – Mechanismen ihres Abbaus.- Der programmierte Zelltod - Apotose, Nektrotose, Ferroptose und Pyroptose.- Prinzipien der zellulären Tumorgenese und –progression.- Das Tumorstroma.- Gentechnik.- Gentechnik in höheren Organismen – Transgene Tiere und Gentherapie.- V Funktionelle Biochemie der Organe: Energiebilanz und Ernährungszustand.- Makronährstoffe und ihre Bedeutung.- Fettlösliche Vitamine.- Wasserlösliche Vitamine.- Spurenelemente.- Gastrointestinaltrakt.-Leber - Zentrales Stoffwechselorgan.- Quergestreifte Muskulatur.- Die glatte Muskulatur.- Niere – Ausscheidung von Wasser und Elektrolyten.- Niere – Der Säure-Basen- und Mineralhaushalt.- Blut – Zelluläre Bestandteile und Blutplasma.- Blut – Hämatopoese und Erythrocyten.- Blut – Thrombocyten und Leukocyten.- Immunologie.- Extrazelluläre Matrix - Struktur und Funktion.- Knorpel- und Knochengewebe.- Haut.- Nervensystem.- Anhang.
£66.49
Springer Fachmedien Wiesbaden Pflanzenbiochemie
Book SynopsisDieses Lehrbuch bietet eine umfassende Übersicht über die fundamentalen Aspekte der Pflanzenbiochemie. Die biochemischen Abläufe in einer Pflanze sind letztendlich eine wesentliche Grundlage des Lebens auf unserem Planeten. Stoffwechselprozesse, wie die Photosynthese, die Kohlendioxid-Fixierung u.v.a., werden ausführlich erklärt. Die Erkenntnisse über diese pflanzenbiochemischen Prozesse könnten genutzt werden, den steigenden CO2-Emissionen auf der Erde entgegenzuwirken. Das Wissen über die molekularen und biochemischen Abläufe in Pflanzen sind also Voraussetzung, das zukünftige Leben auf der Erde zu sichern.Ebenso essenziell sind die Erkenntnisse der Pflanzenmolekularbiologie und -biochemie für die wirtschaftliche Anwendung und Nutzung der Pflanzen. Studierende werden in diesem Werk lernen, welche Schritte erforderlich sind, um transgene Pflanzen zu erzeugen und um Pros und Cons der pflanzlichen Gentechnik abschätzen und vermitteln zu können.In der 6. Auflage wurden zahlreiche Aktualisierungen vorgenommen. Es werden u.a. neue Einblicke zur Evolution der Pflanzen gegeben, und weitere Details des Photosyntheseapparates, der Stärke-Biosynthese und -Regulation, sowie der Funktionen und Biosynthesen von Sekundärmetaboliten dargestellt. Darüber hinaus wird erläutert, wie die molekulare Genschere CRISPR-Cas zur Erzeugung transgener Pflanzen eingesetzt werden kann.Besonderen Wert legen die Autor*innen darauf, durch eine klare und verständliche Didaktik komplexe Sachverhalte darzustellen – das ist ein Kennzeichen dieses Lehrbuches. Mit sorgfältig erstellten Abbildungen erfüllt es einen hohen didaktischen Anspruch und reiht sich unter die besten Biochemie-Lehrbücher. Table of ContentsEinleitung.- Eine Blattzelle ist in mehrere metabolische Kompartimente unterteilt.- Die Energie des Sonnenlichtes und Photosynthese sind die Grundlage für das Leben auf der Erde.- Die Photosynthese ist ein Elektronentransportprozess.- Bei der Photosynthese wird ATP erzeugt.- Die Mitochondrien sind die Kraftwerke der Zellen.- Der Calvin-Benson-Bassham-Zyklus katalysiert die photosynthetische CO2-Assimilation.- Der Photorespirationsweg recycelt Phosphoglykolat.- Polysaccharide sind Speicher- und Transportform der bei der Photosynthese gebildeten Kohlenhydrate.- Die Assimilation von Nitrat wird zur Biosynthese von organischem Material benötigt.- Durch die N2-Fixierung wird der Luftstickstoff für das Pflanzenwachstum nutzbar.- Die Produkte der Nitratassimilation und N2-Fixierung werden in Pflanzen in Form von Proteinen gespeichert.- Die Assimilation von Sulfat ermöglicht die Biosynthese schwefelhaltiger Verbindungen.- Durch den Phloemtransport erreichen die Photoassimilate ihre Verbrauchs- und Speicherorte.- Lipide sind Membranbausteine und Kohlenstoffspeicher.- Spezialmetabolite erfüllen in Pflanzen spezielle biologische und ökologische Funktionen.- Die große Vielfalt der Isoprenoide.- Viele pflanzlichee Spezialmetabolite und Zellwandbestandteile sind Phenylpropanoide.- Vielfältige Signale koordinieren Wachstum und Entwicklung verschiedener Pflanzenorgane und ermöglichen die Anpassung an unterschiedliche Umweltbedingungen.- Eine Pflanzenzelle besitzt drei verschiedene Genome.- Biosynthese, Prozessierung und Abbau von Proteinen in Pflanzen.- Durch Gentechnik können Pflanzen den Bedürfnissen von Landwirtschaft, Ernährung und Industrie angepasst werden.
£61.74
Springer Fachmedien Wiesbaden Endlich Biochemie verstehen
Book SynopsisDieses Buch beantwortet brennende Fragen nach dem (molekularen) Sinn des Lebens und macht Lust auf mehr. Was ist es denn „was die Welt, im Innersten zusammenhält“. Das Buch ist als Lehrbuch konzipiert und macht übergeordnete Konzepte der Biochemie mit einfachen Bildern begreifbar. Die Konzepte oder spannenden Fragen der Kapitel werden mit viel Witz und über einfache Eselsbrücken den Studierenden näher gebracht. Table of ContentsSpielregeln.- Der LEGO-Baukasten des Lebens.- DNA oder das Buch des Lebens.- Wie entsteht Ordnung aus dem Chaos?.- Wie setzt man eine chemische Reaktion in Gang? ...auch dann, wenn sie eigentlich nicht will?.- Die Renaissance des Stoffwechsels – vom trockenen Prüfungsstoff zur modernen Metabolismus-Forschung.- Es werde Licht – Das einzige wirklich grüne Kapitel.- Was Evolution wirklich ist....- Wie liest (und schreibt) man wissenschaftliche Veröffentlichungen am besten?.- Epilog: Mein Lebenslauf anhand meiner Lieblingsmoleküle.- Glossar – von Anabolismus bis Zielmolekül.
£18.99
Harwood-Academic Publishers Toxins and Targets
Book SynopsisFirst Published in 1992. The last decade of the twentieth century has seen an unprecedented advocacy for the preservation of a safe environment, and the prevention of ill-health from toxic chemicals. Human activity, however, is responsible for introducing new toxins into the environment. In order to control competitors for human food sources, an armament of pesticides has been assembled and their widespread and largely uncontrolled application has been permitted. It is only when the health of the population begins to suffer from the effects of these chemicals that the efficacy of their use is questioned. Decision-makers whose roles involve the promotion and control of the environment must look to lessons that can be learnt from biosystems that include animals other than man. Toxins and Targets details the way in which organisms from diverse habitats in the plant and animal kingdoms have adapted to handle toxins safely. Part I, on the aquatic environment, highlights the means by which marine organisms have adapted their toxins to be effective in a world of high aqueous solubility and infinite dilution. Part II deals with venomous terrestrial organisms and the mechanisms by which they damage animal cells, and Part III considers the way in which human society attempts to investigate toxicity and to control both synthetic and naturally occurring poisons. The development of a safe environment depends on increased knowledge and novel approaches to solving escalating problems. This book is a step towards this end.Table of ContentsPARTIAQUATIC ECOSYSTEMS Chapter 1 Dlnoflagellate Toxins In Australian Shellfish Chapter 2 Coneshell Venoms-Synthesis and Packaging Chapter 3 Peptides In the Venom of the Geography Cone, Conus geographus Chapter 4 Coneshell Toxin Genes Chapter 5 Toxins from Sea-Squirts Chapter 6 Poisoning by Blue-Green Algae Chapter 7 Soft Corals and Their Toxins PART II DAMAGE TO ANIMAL CELLS Chapter 8 lmmunotherapy for Cancer-Toxin-Antibody Conjugates Chapter 9 A Tick Toxin Chapter 10 A Cycad Neurotoxln Chapter 11 Clguatera Poisoning Chapter 12 Funnel-Web Spider Toxins Chapter 13 Tetanus Toxin Chapter 14 The Exotoxln of Melloldosls, a Disease of Animals and Man Chapter 15 Two Naturally Occurring Toxins Causing Stock Losses Chapter 16 A Jellyfish Toxin Chapter 17 Snake Venom-Haemostatic Components Chapter 18 A Toxic Protein from the AIDS Virus PART Ill POLLUTION, PEOPLE AND PREVENTION Chapter 19 Toxicity Testing Chapter 20 The Effects of Chloropropanes on Spermatozoa Chapter 21 Blomonltorlng of DNA-Damaging Toxins Chapter 22 Organochlorlnes-Pollutants and Human Carcinogens Chapter 23 Ecotoxlcology
£123.50
Hirzel S. Verlag Biochemie fr Ahnungslose Eine Einstiegshilfe fr
Book Synopsis
£30.60
Spektrum Akademischer Verlag Bild-DVD, Biochemie: Die Abbildungen Des Buches
Book Synopsis
£6.95
Spektrum Akademischer Verlag Hundepsychologie: Experimentelle Streifzüge in
Book SynopsisVorwort.- 1. Gar nicht so schlecht! Im Gegenteil!- 2. Haustiere sind unsere Freunde.- 3. Ich habe eine tierisch gute Gesundheit.- 4. Schluss mit den Antidepressiva! Ja zu Hunden, Katzen, Delfinen und Kaninchen.- 5. Schüchtern?Schaffen Sie sich einen Hund an!- Zusammenfassung: Auch wir beeinflussen sie.- Literatur.- Index
£21.84
Spektrum Akademischer Verlag Lerntafel: Biochemie im Überblick
Book Synopsis
£8.16
