Oncology Books
Springer Nature Switzerland AG The Thorax
Book SynopsisThis book highlights the differences, in terms of neoplastic dissemination pathways, between various types of thoracic cancers. It presents and discusses a comprehensive schematic overview of tumors of the lung parenchyma, of the mediastinum, of the pleura, and of the chest wall. For each tumor, it details the local spread and the lymphatic and vascular dissemination, and it describes the challenging staging of lung tumors with mutations. Illustrations and artwork enrich the content and help readers to understand and visualize tumor spread. The book is of great interest to professionals involved in the study, diagnosis and treatment of thoracic pathologies, as well as to residents in radiology, oncology and pulmonology.Table of ContentsChapter 1: Mechanisms of tumour dissemination in thoracic neoplasms.- Chapter 2: Radiological Signs of Tumour Dissemination.- Chapter 3: NSCLC: common types.- Chapter 4: NSCLC: rare types.- Chapter 5: Pulmonary neuroendocrine tumours.- Chapter 6: Tumours of the thymus.- Chapter 7: Other Mediastinal tumours.- Chapter 8: Tumours od the Pleura.- Chapter 9: Tumours of the chest wall.
£999.99
Springer Nature Switzerland AG Exercise Oncology: Prescribing Physical Activity
Book SynopsisThis groundbreaking book presents a unique and practical approach to the evolving field of exercise oncology - the study of physical activity in the context of cancer prevention and control. Presenting the current state of the art, the book is sensibly divided into four thematic sections. Following an opening chapter presenting an overview and timeline of exercise oncology, the chapters comprising part I discuss primary cancer prevention, physical activity and survivorship, and the mechanisms by which these operate. Diagnosis and treatment considerations are discussed in part II, including prehabilitation, exercise during surgical recovery, infusion and radiation therapies, and treatment efficacy. Post-treatment and end-of-life care are covered in part III, including cardio-oncology, energetics and palliative care. Part IV presents behavioral, logistical and policy-making considerations, highlighting a multidisciplinary approach to exercise oncology as well as practical matters such as reimbursement and economics.Written and edited by experts in the field, Exercise Oncology will be a go-to practical resource for sports medicine clinicians, family and primary care physicians, oncologists, physical therapy and rehabilitation specialists, and all medical professionals who treat cancer patients.Table of ContentsChapter 1. Exercise Oncology: Past and Present Kathryn H. SchmitzPart 1 - Physical Activity and Cancer Prevention Chapter 2. Primary PreventionErika Rees-Punia, Alpa V. Patel Chapter 3. Physical Activity and Cancer SurvivalChristine M. Friedenreich, Chelsea R. Stone, Sandra C. Hayes Chapter 4. Mechanisms of Exercise in Cancer Prevention, Treatment and SurvivorshipHannah Savage, Keri L. Schadler Part 2 - From Diagnosis through TreatmentChapter 5. Exercise Oncology from Diagnosis through Treatment: An Overview of Outcomes and ConsiderationsCiaran M. Fairman, Daniel A. GalvãoChapter 6. Prehabilitation: An Emerging Standard in Exercise OncologyNicole L. Stout, Julie K Silver, Jennifer Baima, Sasha E. Knowlton, Xiaorong HuChapter 7. Exercise during Surgical Recovery Rosa M. Pasculli, Jonas Sokolof, Elizabeth Olecki, Kelly Stahl, Niraj GusaniChapter 8. Exercise during Infusion TherapyKristin L. Campbell, Amy KirkhamChapter 9. Exercise During Radiation TherapyJoachim WiskemannChapter 10. Effects of Exercise on Cancer Treatment Completion and EfficacyAndria R. Morielli, Kerry S. Courneya Part 3 – Post-treatment to End of LifeChapter 11. Exercise Oncology from Post-Treatment to End of Life: An Overview of Outcomes and ConsiderationsKira Bloomquist, Sandra C. Hayes Chapter 12. Exercise during Immediate Post-treatment Kerri Winters-Stone, Mary Medysky, Anna L. SchwartzChapter 13. Long-term and Late Effects of Cancer Treatments on Prescribing Physical ActivityAnna L. Schwartz, Jennifer W. Bea, Kerri Winters-StoneChapter 14. Exercise and Cardio-OncologyAmy M. Berkman, Susan C. Gilchrist Chapter 15. Energetics and Cancer OutcomesLeah M. Ferrucci, Melinda L. IrwinChapter 16. Exercise for Advanced Cancers, Metastatic Disease and Palliative CareSonya Lowe, Christopher Sellar, Kirsten Suderman, Margaret L. McNeely Part 4 - Behavior, logistics, and policyChapter 17. Cancer Survivors Becoming and Staying Physically Active: Challenges of Behavior ChangeBernardine M. Pinto, Madison M. Kindred, Chloe GrimmettChapter 18. Making Exercise Standard in Cancer Care Karen Basen-Engquist, Nathan H. ParkerChapter 19. Viewing Exercise Oncology through the Lens of MultidisciplinarityMartijn M. StuiverChapter 20. Policy and Reimbursement Considerations for Exercise Programming in CancerAndrea Cheville, Jennifer Baima, Philip Chang, Charles Mitchell, Stephanie Otto, Sonal Oza, David S. ZuckerChapter 21. Shaping the Future of Exercise OncologyKathryn H. Schmitz
£67.49
Springer Nature Switzerland AG Soft Tissue Tumors: A Practical and Comprehensive Guide to Sarcomas and Benign Neoplasms
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£999.99
Springer Nature Switzerland AG Liver Intra-arterial PRRT with 111In-Octreotide: The Tumoricidal Efficacy of 111In Auger Electron Emission
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£71.99
Springer Nature Switzerland AG Clinical Cases in Pediatric Skin Cancers
Book SynopsisThis book is a concise practical guide designed to facilitate the clinical decision-making process in the management of pediatric skin cancers. Dermatologists, oncologists and general pediatricians who offer primary care to children must be knowledgeable in identifying and managing dermatological cancers, and this title provides insightful reviews of a number of common and rare dermatologic cases. Clinical cases are a key component in modern medical education, assisting the trainee or recertifying clinician to work through unusual scenarios using best practice techniques. Pediatric dermatology is a particularly important discipline in this regard since it is a highly visual subject requiring the reader to describe often very subtle differences in the presentation of patients and define accurately the diagnostic and management criteria on which to base their clinical decision-making. Clinical Cases in Pediatric Skin Cancers concisely covers how to approach diagnosing and managing skin cancers in pediatric patients. Each chapter focuses on a particular case and emphasizes how to make an appropriate choice when deciding which diagnostic tool or management strategy would be most suitable. Potential complications are detailed and management tips provided to enable the reader to develop a deep understanding of how approach the care of these patients within their day-to-day clinical practice. This book therefore represents an ideal up-to-date resource for all practitioners who encounter these cases as part of their everyday practice.Table of Contents20-30 cases/chapters of 4-6 pages (=c. 2500 words) that cover the discipline in a structured fashion and covering all aspects of the topicChapters will include the following:Conventional melanoma Spitzoid melanomaCongenital melanocytic nevus MelanomaBasal Cell CarcinomasSquamous Cell Carcinomas Benign skin neoplasmsGenetic skin neoplasmsVirus induced skin neoplasms in children
£61.74
Springer Nature Switzerland AG Assessment of Cancer Screening: A Primer
Book SynopsisCancer screening is a prominent strategy in cancer control in the United States, yet the ability to correctly interpret cancer screening data eludes many researchers, clinicians, and policy makers. This open access primer rectifies that situation by teaching readers, in simple language and with straightforward examples, why and how the population-level cancer burden changes when screening is implemented, and how we assess whether that change is of benefit. This book provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics. Concise, accessible, and focused, Assessment of Cancer Screening: A Primer is best suited to those with education or experience in clinical research or public health in the United States - no previous knowledge of cancer screening assessment is necessary. This is the first text dedicated to cancer screening theory and methodology to be published in 20 years.Table of ContentsFoundations.- Behind the scenes.- Performance measures.- Population measures: definitions.- Population measures: cancer screening’s impact.- Experimental research designs.- Observational research designs.- Cancer prevention screening.- Additional considerations.- Closing thoughts
£33.24
Springer International Publishing AG PET Radiopharmaceuticals: Chemical, Biological, and Clinical Data
Book SynopsisThis book presents in a consistent format data on ~50 PET radiopharmaceuticals in clinical use. Parameters include basic chemical data, normal biodistribution and excretion, activity administered, radiation dosimetry, patient preparation, and clinical utility, together with a few key references. In some cases a representative image is presented. The organisation is first by clinical specialty (oncology, cardiology, neurology) and within each section by radionuclide (F-18, C-11, etc). This book will be of interest mostly to nuclear medicine physicians and trainees, but also to a wider medical community including radiologists, oncologists and radiotherapists.Table of ContentsChapter 1: Oncology – 18F-labelled agents.- Chapter 2: Oncology – 11C-labelled agents.- Chapter 3: Oncology – 68Ga-labelled agents.- Chapter 4: Oncology – other agents.- Chapter 5: Cardiology – 18F-labelled agents.- Chapter 6: Cardiology – other agents.- Chapter 7: Neurology – 18F-labelled agents.- Chapter 8: Neurology – 11C-labelled agents.- Chapter 9: Neurology – 15O-labelled agents.
£999.99
Springer International Publishing AG Epigenetics in Oncology
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£98.99
Springer International Publishing AG Medical Robotics
Book SynopsisThis book provides a thorough background to the emerging field of medical robotics. It covers the mathematics needed to understand the use of robotic devices in medicine, including but not limited to robot kinematics, hand-eye and robot-world calibration, reconstruction, registration, motion planning, motion prediction, motion correlation, motion replication and motion learning. Additionally, basic methods behind state-of-the art robots like the DaVinci system, the CyberKnife, motorized C-arms and operating microscopes as well as stereotactic frames are presented. The book is a text book for undergraduates in computer science and engineering.The main idea of the book is to motivate the methods in robotics in medical applications rather than industrial applications. The book then follows the standard path for a robotics textbook. It is thus suitable for a first course in robotics for undergraduates. It is the first textbook on medical robotics.Table of ContentsIntroduction.- Describing Spatial Position and Orientation.- Robot Kinematics.- Joint Velocities and Jacobi-Matrices.- Navigation and Registration.- Treatment Planning.- Motion Correlation and Tracking.- Motion Prediction.- Motion Replication.- Applications of Surgical Robotics.- Rehabilitation, Neuroprosthetics and Brain-Machine Interfaces.
£49.49
Springer International Publishing AG Breast Cancer: Innovations in Research and
Book SynopsisThis book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.Table of ContentsPart I An Integrated view of Breast Cancer Biology.- Fundamental pathways in breast cancer 1: signaling from the membrane.- Fundamental pathways in breast cancer 2: maintenance of genomic stability.-Fundamental pathways in breast cancer 3: estrogen biology.- Fundamental pathways in breast cancer 4: maintenance of epigenomic stability and the role of stem cells.- Breast cancer microenvironment and the metastatic process.- Mouse models of breast cancer.- Human mammary tumor virus proteins in human breast cancer cells.- Part II Epidemiology, Genetics and Prevention.- Epidemiology, life style and environment.- Genetic predisposition.- Chemoprevention.- Surgical prevention.- Part III Pathology: Standard and Molecular Diagnostics.- Premalignant lesions.- Prognostic and predictive role of genetic signatures.- Adding molecular information to immunohistochemistry.- Special types of breast cancer and nonepithelial tumors.- Pathology after neoadjuvant treatments.- Breast cancer genomics.- Pathology report 2015.- Part IV Imaging.- Radiological screening of breast cancer. Evolution.- Innovation of radiological means for breast cancer.- Nuclear medicine in the clinical management (ROLL, SNB and PET).- One-step systemic staging for patients with breast cancer.- Imaging after breast surgery.- Integrated breast biopsy for best radiological diagnosis of breast cancer.- Part V Oncological Surgery.- Conservative surgery.- Conservative mastectomies.- Surgical treatment of reappearance of breast cancer.- Management of the axilla.- Management of intraepithelial disease.- Surgery after neoadjuvant therapies.- Surgery of primary tumor in stage IV breast cancers.- Local therapy for breast cancer in malignant lymphoma survivors.- Surgery of metastases.- Part VI Plastic and Reconstructive Surgery.- Oncoplastic surgery.- Delayed breast reconstruction.- Immediate breast reconstruction direct-to-implant.- Breast reconstruction with tissue expanders and definitive implant replacement.- Breast reconstruction with pedicled flaps.- Breast reconstruction with free flaps.- Contralateral breast management.- Fat grafting in breast reconstruction.- Breast reconstruction with biological and nonbiological meshes.- How to manage complications in breast reconstruction.- Part VII Medical Oncology.- Adjuvant systemic therapies by subtypes: guidelines.- Primary systemic therapies: guidelines.- Treatment of advanced disease: guidelines.- Endocrine therapies in the adjuvant and advanced disease settings.- Chemotherapy regimens in the adjuvant and advanced disease settings.- Anti-HER2 therapies in the adjuvant and advanced disease settings.- Systemic therapy with bisphosphonates and anti-RANK-L agents.- Systemic treatment for specific medical situations.- Part VIII Radiotherapy.- Conceptual basis and principles of radiation oncology.- Whole breast radiation following breast-conserving surgery in invasive cancer.- Whole breast radiation following breast-conserving surgery in noninvasive cancer.- Post-mastectomy radiotherapy.- Integration of radiotherapy with systemic therapies.- Partial breast irradiation.- Intraoperative radiotherapy ELIOT.- Radiotherapy for metastatic lesions.- Part IX Special Conditions Requiring Multidisciplinary Approaches.- Emergencies in breast cancer.- Breast cancer during pregnancy.- Fertility issues in patients with newly diagnosed breast cancer.- Sexual functions and breast cancer.- Male breast cancer.- Inflammatory breast cancer.- Treatment of CNS involvement.- Treatment of skeletal disease.- Follow-up of patients with breast cancer.- Part X Investigating New Drugs and Immunological Agents in Breast Cancer.- Targeting immune-checkpoint.- Targeting PIK3CA/AKT/mTOR.- Targeting genome instability and DNA repair.- Targeting CDK4/6 pathway.- Targeting FGFR pathway.- Integrating next generation sequencing data in trial design.- Part XI Investigational and Miscellaneous Approaches.- Lifestyle and breast cancer.- Psychological support.- HIFU and radiofrequency as alternatives to surgery.- Hyperthermia with RT and with systemic therapies.- Electro-chemotherapy.- Circulating miRNA in early diagnosis.- Relevance of stem cells.- Part XII Biostatistics and Bioinformatics.- Subgroup analyses and information from clinical trials on breast cancer.- The methodology of meta analyses and its potential contribution to patient care.- Modern biostatistics for accelerated data acquisition for new drugs.- Bioinformatics for clinical use in breast cancer.- Efficacy endpoints in breast cancer studies.
£999.99
Springer International Publishing AG PET/CT in Lung Cancer
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£999.99
Springer International Publishing AG Metastatic Spine Disease: A Guide to Diagnosis
Book SynopsisThis comprehensive text focuses exclusively on the management of metastatic spinal disease, evaluating the most recent literature and providing patient-centered treatment algorithms. Beginning with initial imaging, classification and clinical decision-making, the spine is approached anatomically from the upper cervical to the sacrum, describing the unique considerations and approaches appropriate to each region, such as laminectomy and stabilization, en bloc spondylectomy and resection and reconstruction. Less invasive and minimally invasive approaches are discussed throughout the text. Radiation therapy modalities and other adjuvant treatments are also discussed, as well as reconstructive flap coverage and the management of complications. The spinal column is the most common site of metastatic cancer, and a multidisciplinary approach is required to provide patients with reasonable management options to prevent and treat the disabling symptoms caused by this debilitating condition. This compendium of experience from thought leaders in the treatment of metastatic spine disease will provide spine surgeons, oncologists, radiation oncologists, physiatrists and palliative care specialists with up-to-date information to guide their patients through the multidisciplinary management of metastatic spinal disease.Trade Review “This book is very well written and provides a comprehensive review of malignant spinal cord compression, suitable for audiences in different specialities as it embodies the multi- disciplinary approach in decision-making. … It is an enjoyable read and easily digestible, and it is highly recommended to everyone involved in acute medical care.” (Calvin Soh, RAD Magazine, May, 2019)“This is an important book for anyone treating metastatic spine disease. It covers this topic in comprehensive fashion for those desiring an in-depth review. … a ready reference for the resident, fellow, or practicing surgeon seeing a patient in the emergency room or clinic. I highly recommend this book, and the editor and authors are to be commended for their important contribution.” (Laurence D. Rhines, Neurosurgery, Vol. 84 (4), April, 2019)Table of ContentsMOSS: A Patient Centered Approach.- Relative Radiosensitivity of Metastatic Spine Disease.- Relative Chemo-, Hormonal, and Immunosensitivity.- Noms.- Spinal Instability in Metastatic Disease.- Imaging Metastatic Spinal Disease.- Management of metastatic spinal cord compression without stereotactic radiotherapy and targeted adjuvant chemotherapy.- Metastatic Spine Disease: Critical Evaluation of the Current Literature.- Indications for en Bloc Spondylectomy for Metastatic Spine Disease.- Occipitocervical and Upper Cervical Metastatic Spinal Disease.- Mid-Cervical Metastatic Spinal Disease.- Cervicothoracic Metastatic Spine Disease.- Surgical Treatment for Patients with Thoracic Spinal Metastasis.- Thoracolumbar Metastatic Spinal Disease.- Indications and Techniques for Anterior Thoracolumbar Resections and Reconstructions.- Metastatic Disease of the Lumbar Spine.- Vertebral Body Reconstruction in Metastatic Spine Disease.- Lumbosacral Metastatic Spine Disease.- Sacral Metastases.- Radiation Therapy for Spinal Metastases.- Reconstructive Flap Coverage.- Complications .- Percutaneous Thermal Ablation of Spine Metastasis.- Minimally invasive spine surgery for metastatic spine disease .
£999.99
Birkhauser Verlag AG Molecular Determinants of Head and Neck Cancer
Book SynopsisSquamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.Trade Review“The book is intended primarily for clinicians, fellows, interns, and trainees, but medical students who may be interested in head and neck cancer but face the challenge of updating themselves on the latest innovations may also find this book very useful. … this is an informative and authoritative book on the subject that includes experiences from clinicians and scientists working on head and neck cancer at some of the most renowned cancer centers in the world.” (Ravi Salgia, Doody's Book Reviews, March, 2019)Table of ContentsChapter 1: Overview: B. Burtness and E. GolemisChapter 2: HER inhibition in HNC: E. Golemis and B. BurtnessChapter 3: MET: T Beck, Fox Chase Cancer CenterChapter 4: PI3K/mTOR/AMPK: C. Chung, Moffit Cancer CenterChapter 5: Jak/STAT: J.R. Grandis, UCSFChapter 6: TGFb: Neiman and Wang, University of ColoradoChapter 7: Wnt and catenin Signaling: MA Kukurusinska, Boston UniversityChapter 8: P53/p63/p73: B. BurtnessChapter 9: DNA damage: R. Bindra, Yale UniversityChapter 10: APOBEC Proteins: K.S. Anderson, Yale UniversityChapter 11: Hypoxia, including HIF1: Q. Le, Stanford UniversityChapter 12: VEGF/Angiogenesis and Antiangiogenic Therapy: A Argiris, Thomas Jefferson UniversityChapter 13: Sequencing/genomic insights: J.Myers, MD AndersonChapter 14: Gene expression, Methylation, and histones: R.Mehra, A.Andrews, S.Peri, Fox Chase Cancer Center and A.Bhatia, Yale UniversityChapter 15: Inflammation: Carter Van Waes, NIHChapter 16:Immunotherapy: Ferris and Baumann, UPMCChapter 17: FAK/Integrin pathway inhibitors: Nils Cordes, DresdenChapter 18: Targeting cell cycle controls: E.GolemisChapter 19: Head and neck cancer stem cells: L.Bourguignon, UCSFChapter 20: Non-coding RNAs: C.Punyadeera, Queensland UniversityChapter 21: Epidemiology of HPV: Ragin and Lui, Fox Chase Cancer CenterChapter 22: DNA damage in HPV-positive SCCHN: WG Yarbrough, Yale UniversityChapter 23: Treatment paradigms in HPV-positive SCCHN: A Cmelak, Vanderbilt University
£116.99
Springer International Publishing AG Atlas of Full Breast Ultrasonography
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£104.49
Springer International Publishing AG Imaging of Soft Tissue Tumors
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£125.99
Springer International Publishing AG Mechanisms of Molecular Carcinogenesis – Volume 2
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£999.99
Birkhauser Verlag AG Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management
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£98.99
Springer International Publishing AG Inflammation and Angiogenesis
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£80.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imaging of Soft Tissue Tumors
Book SynopsisThis richly illustrated book provides a comprehensive survey of the growing role of medical imaging studies in the detection, staging, grading, tissue characterization, and post-treatment follow-up of soft tissue tumors. For each tumor group, imaging findings are correlated with clinical, epidemiologic, and histologic data. The relative merits and indications of various imaging modalities are discussed and compared. Particular emphasis is placed on MRI because of its unique contrast resolution and multiplanar imaging capabilities. This third, revised and updated edition includes new chapters on genetics and molecular biology and on pathology of soft tissue tumors, with respect to the new World Health Organization (WHO) classification of soft tissue tumors. It aims to serve both as a systematic, descriptive textbook and as a rich pictorial database of soft tissue masses. The addition of numerous new illustrations of common and rare soft tissue tumors will further increase the scientific and educational value of this third edition.Trade ReviewFrom the reviews of the third edition: RAD-Magazine, Nov. 2006: "There is a lot of knowledge and experience between the two book covers, which is well presented...." "This third edition of ‘Imaging of soft tissue tumors’ has been considerably enlarged by using the bank data of the Belgian Soft Tissue Neoplasm Registry. … This new edition should be recommended to radiologists and nuclear medicine doctors, surgeons, oncologists, graduated or in training, but it is also of interest for the specialists related to the different soft tissues." (F Duparc, Surgical and Radiologic Anatomy, Vol. 28, 2006)Table of ContentsDiagnostic Modalities.- Ultrasound of Soft Tissue Tumors.- Color Doppler Ultrasound.- Plain Radiography, Angiography, and Computed Tomography.- Nuclear Medicine Imaging.- Magnetic Resonance Imaging.- Dynamic Contrast-Enhanced Magnetic Resonance Imaging.- Cytogenetics and Molecular Genetics of Soft Tissue Tumors and Bone Tumors.- Soft Tissue Tumours: the Surgical Pathologist’s Perspective.- Biopsy of Soft Tissue Tumors.- Staging, Grading, and Tissue Specific Diagnosis.- Staging.- Grading and Tissue-Specific Diagnosis.- General Imaging Strategy of Soft Tissue Tumors.- Imaging of Soft Tissue Tumors.- Tumors of Connective Tissue.- Fibrohistiocytic Tumors.- Lipomatous Tumors.- Tumors and Tumor-like Lesions of Blood Vessels.- Lymphatic Tumors.- Tumors of Muscular Origin.- Synovial Tumors.- Tumors of Peripheral Nerves.- Extraskeletal Cartilaginous and Osseous Tumors.- Primitive Neuroectodermal Tumors and Related Lesions.- Lesions of Uncertain Differentiation.- Pseudotumoral Lesions.- Soft Tissue Metastasis.- Soft Tissue Lymphoma.- Imaging of Soft Tissue Tumors in The Pediatric Patient.- Imaging After Treatment.- Follow-Up Imaging of Soft Tissue Tumors.
£210.00
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Decision Making in Radiation Oncology: Volume 1
Book SynopsisDecision Making in Radiation Oncology is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions effectively and efficiently. The design is based on the belief that “a picture is worth a thousand words.” Knowledge is conveyed through an illustrative approach using algorithms, schemas, graphics, and tables. Detailed guidelines are provided for multidisciplinary cancer management and radiation therapy techniques. In addition to the attention-riveting algorithms for diagnosis and treatment, strategies for the management of disease at individual stages are detailed for all the commonly diagnosed malignancies. Clinical trials that have yielded “gold standard” treatment and their results are documented in the schemas. Moreover, radiation techniques, including treatment planning and delivery, are presented in an illustrative way. This groundbreaking publication is an essential tool for physicians in their daily clinical practice.Trade ReviewFrom the book reviews:“This is a comprehensive, full color atlas and text about various head and neck, breast, thoracic, and palliative care for oncology. … I highly recommend this book to oncologists, radiosurgeons, and physicians. … I heartily recommend this publication for all readers for a quick reference book.” (Joseph J. Grenier, Amazon.com, September, 2014)Table of ContentsVolume 1: Introduction .- Section I: Head and Neck Cancers: Orbital and Ocular Malignancies.- Nasopharyngeal Carcinoma.- Cancer of Oral Cavity and Oropharynx.- Malignant Tumors of the Major Salivary Glands.- Cancer of Larynx and Hypopharynx.- Squamous Cell Carcinoma of Unknown Head and Neck Primary.- Thyroid Cancer.- Section II: Breast Cancer: Breast Cancer.- Section III: Tumors of the Thorax: Lung Cancer (NSCLC & SCLC).- Thymoma.- Esophageal Cancer.- Section IV: Cancers of the Gastrointestinal Tract: Gastric Cancer.-Pancreatic Cancer.- Hepatobiliary Tumors.- Rectal Cancer .- Cancer of the Anal Canal.-Volume 2: Section V: Tumors of the Genitalurinary System: Cancer of the Bladder.- Cancer of the Prostate.- Testicular Cancer.- Section VI: Gynaecological Cancers: Endometrial Cancer.-Cancer of the Cervix.- Vulva Cancer.- Vaginal Cancer.- Section VII: Lymphomas: Non-Hodgkin’s Lymphoma.- Hodgkin’s Disease.- Multiple Myeloma and Plasmacytoma.-Cutaneous T-Cell Lymphoma.- CNS Lymphoma.- Section VIII: Tumors of the Central Nervous System: Meningioma.- Adult Glioma.- Pituitary Tumors.- Section IX: Skin Cancers and Soft Tissue Sarcoma: Skin Cancers including Melanoma.- Soft Tissue Sarcoma.- Section X: Pediatric Tumors: Pediatric CNS Tumors.- Retinoblastoma.- Neuroblastoma.- Ewing’s Sarcoma.- Wilm’s Tumor.- Section XI: Other: Palliative Radiation for Brain Metastasis.- Palliative Radiation for Bone Metastasis.- Appendix I: TD 5/5 (table).- Appendix II: Performance Status Scales.- Subject Index.
£219.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Two Faces of Evil: Cancer and Neurodegeneration
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£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Clinical Ophthalmic Oncology: Orbital Tumors
Book SynopsisWritten by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types.Trade Review“The volume covers all steps of the treatment process, from diagnostics reflections through surgical techniques and rehabilitation of the patient at the end of the medical treatment itself. The book consists of 19 chapters beginning with examination techniques and classification of orbital tumors. … The large number of clinical and histological images is of very high quality. … the second edition of ‘Orbital Tumors’ by Perry and Singh is a ‘must-read’ for all ophthalmologists treating patients with orbital diseases.” (Eckart Bertelmann, Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 254, 2016)Table of ContentsExamination Techniques.- Classification of Orbital Tumors.- Differential Diagnosis in Child.- Differential Diagnosis in Adults.- Imaging Techniques.- Non-Specific Orbital Inflammation.- Orbital Vascular Tumors.- Benign Orbital Tumors.- Optic Nerve Tumors.- Lacrimal Gland Tumors.- Lacrimal Sac Tumors.- Orbital and Adnexal Lymphoma.- Malignant Orbital Tumors.- Orbital Rhabdomyosarcoma.- Enucleation for Ocular Tumors.- Orbital Exenteration.- Principles of Orbital Surgery.- Orbital Implants.- Ocular Prosthesis.
£116.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG The Sentinel Node in Surgical Oncology
Book SynopsisIn this volume an account is given of the technologies relevant to the detection of sentinel lymph nodes in the context of surgical oncology. This is a rapidly and evolving field, and the clinical applications discussed in this volume are exciting and important. A multidisciplinary team was assembled to discuss this subject in the light of direct experience gained by each of the groups in the previous 12 months. Clinical case material is presented and the methodology of sentinel lymph node imaging and detection is discussed in detail. The authors have assembled in a single volume a significant amount of personal data and a comprehensive literature review which will serve as a single reference and teaching source for all those interested in this critical technique relevant to the management of large numbers of patients in surgical oncology.Trade Review"...an excellent overview of a rather fashionable topic ...very didactic, with a wealth of colour pictures illustrating techniques, anatomy, histology and imaging procedures ...the contents are highly up-to-date and accurately report the data available today. I would recommend it to all surgeons, oncologists. histopathologists and nuclear medicine physicians." European Journal of Nuclear MedicineTable of Contents1. Sentinel Node Detection and Imaging 2. Radiopharmaceuticals 3. Radiation Detectors 4. How to choose a probe 5. Injection Techniques 6. Imaging Techniques 7. Surgical Techniques 8. Dosimetry and Radioation Protection 9. Histopathology of the Sentinel Node 10. Cytology of the Sentinel Node 11. Clinical Case Material 12. Malignant Melanoma: European Practice 13. Preliminary Study of Cost 14. The Future Subject index
£40.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG New Anticancer Drugs: Fourth Annual Program Review Symposium on Phase I and II in Clinical Trials, Tokyo, Japan, June 5-6, 1978. US Japan Agreement on Cancer Research
Table of Contentsof U.S.-Japan Joint Meeting on Phase I and II Clinical Trials.- The New NCI Screen and Its Implications for Clinical Evaluation.- The National Cancer Institute’s Natural Products Antineoplastic Development Program.- Methodology of Phase I Study in Japan.- Methodology of Phase II Clinical Trial in Cancer.- Phase II Study of Antineoplastic Agents in Japan.- Clinical Strategy for Evaluation of Anthracycline Analogues.- Preliminary Clinical Study of Aclacinomycin A.- Preclinical and Clinical Studies on Chlorozotocin, a New Nitrosourea with Decreased Bone Marrow Toxicity.- Continuation of Phase II Study of 1-(4-Amino-2-Methylpyrimidine-5-yl)-Methyl-3-(2-Chloroethyl)-3-Nitrosourea Hydrochloride (ACNU).- Review of Experimental Studies on Nitrosourea Derivates in Japan.- The Clinical Evaluation of Analogues, IV. Nitrosoureas.- Review of a New Antimetabolic Agent, 1-Hexylcarbamoyl-5-Fluorouracil (HCFU).- Review of a New Antimetabolic Agent, 1,1-Bis(Tetrahydro-2-Furanyl)-5-Fluoro-2,4-Pyrimidinedione (FD-1).- Effect and Mode of Action of N4-Behenoyl-?-D-Arabinofuranosylcytosine.- Strategy for Evaluation of a New Antitumor Agent in the Treatment of Breast Cancer.- Current Status of Breast Cancer Chemotherapy in Japan.- Present Status of Lung Cancer Chemotherapy in Japan.- Clinical Strategies in the Chemotherapy of Gastrointestinal Cancer.- Clinical Evaluation Strategy in Specific Disease Types — Clinical Study of Gastrointestinal Cancer Chemotherapy in One Institute of Japan.- A Review of Therapeutic Strategies for Phase I-II Trials in Genitourinary Cancer.- Recent Results of Using a Sequential Combination of Bleomycin and Mitomycin C in the Treatment of Metastatic Cervical Cancer.- Pharmacologic and Clinical Studies of N4-Behenoyl-1-Beta-D-Arabinofuranosylcytosine.
£89.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Early Detection and Localization of Lung Tumors in High Risk Groups
Book SynopsisCarcinogenesis.- Inhalation Carcinogenesis: An Overview.- Lung Carcinogenesis During in Vivo Cigarette Smoking and Radon Daughter Exposure in Rats.- Epithelial Lesions Induced by Alpha Particles and Cigarette Smoke Condensates in Organotypic Culture of Human Bronchus.- Asbestos Carcinogenesis: Asbestos Interactions and Epithelial Lesions in Cultured Human Tracheobronchial Tissues and Cells.- Histogenesis.- The Contribution of Uranium Miners to Lung Cancer Histogenesis.- Pathogenesis of Bronchial Carcinoma, with Special Reference to Morphogenesis and the Influence on the Bronchial Mucosa of 20-Methylcholanthrene and Cigarette Smoking.- Lung Cancer Histogenesis Following in Vivo Bronchial Injections of 20-Methylcholanthrene in Dogs.- Localization of Occult Lung Cancer.- Bronchoscopie Localization of Radiologically Occult Cancer.- Hematoporphyrin Derivative as a Tumor Marker in the Detection and Localization of Pulmonary Malignancy.- Fluorescence Bronchoscopy for Localizing Early Bronchial Cancer and Carcinoma in Situ.- Fluorescence Fiberoptic Bronchoscopy in the Diagnosis of Early Stage Lung Cancer.- Results of Early Lung Cancer Detection Programs.- Results of a Lung Cancer Detection Program in an Asbestos Industry.- Lung Cancer Mortality in Males Screened by Chest X-ray and Cytologic Sputum Examination: A Preliminary Report.- Sputum Cytology and Asbestos Exposure: A Preliminary Report.- Lung Cancer Screening Programs in Canadian Uranium Mines.- Detection of Early and Roentgenologically Occult Bronchogenic Carcinoma: Preliminary Report of the Sabbatsberg Hospital Sputum Cytologic Screening Study.- Results of Lung Cancer Screening Programs in Japan.- Results of the Memorial Sloan-Kettering Lung Project.- Results of the Mayo Lung Project: An Interim Report.Table of ContentsCarcinogenesis.- Inhalation Carcinogenesis: An Overview.- Lung Carcinogenesis During in Vivo Cigarette Smoking and Radon Daughter Exposure in Rats.- Epithelial Lesions Induced by Alpha Particles and Cigarette Smoke Condensates in Organotypic Culture of Human Bronchus.- Asbestos Carcinogenesis: Asbestos Interactions and Epithelial Lesions in Cultured Human Tracheobronchial Tissues and Cells.- Histogenesis.- The Contribution of Uranium Miners to Lung Cancer Histogenesis.- Pathogenesis of Bronchial Carcinoma, with Special Reference to Morphogenesis and the Influence on the Bronchial Mucosa of 20-Methylcholanthrene and Cigarette Smoking.- Lung Cancer Histogenesis Following in Vivo Bronchial Injections of 20-Methylcholanthrene in Dogs.- Localization of Occult Lung Cancer.- Bronchoscopie Localization of Radiologically Occult Cancer.- Hematoporphyrin Derivative as a Tumor Marker in the Detection and Localization of Pulmonary Malignancy.- Fluorescence Bronchoscopy for Localizing Early Bronchial Cancer and Carcinoma in Situ.- Fluorescence Fiberoptic Bronchoscopy in the Diagnosis of Early Stage Lung Cancer.- Results of Early Lung Cancer Detection Programs.- Results of a Lung Cancer Detection Program in an Asbestos Industry.- Lung Cancer Mortality in Males Screened by Chest X-ray and Cytologic Sputum Examination: A Preliminary Report.- Sputum Cytology and Asbestos Exposure: A Preliminary Report.- Lung Cancer Screening Programs in Canadian Uranium Mines.- Detection of Early and Roentgenologically Occult Bronchogenic Carcinoma: Preliminary Report of the Sabbatsberg Hospital Sputum Cytologic Screening Study.- Results of Lung Cancer Screening Programs in Japan.- Results of the Memorial Sloan-Kettering Lung Project.- Results of the Mayo Lung Project: An Interim Report.
£89.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Class 2 Transferases VIII: EC 2.6.1.58 - 2.7.1.37
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£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Reflectance Confocal Microscopy for Skin Diseases
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£132.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Pathology of Pigmented Skin Lesions
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£134.99
Bohn Stafleu van Loghum The history of oncology
Book Synopsis‘The story of oncology is not only fascinating but also contains many accounts of dead ends, chance discoveries, illusions, mistakes and disappointments alongside the few successes.’These words are taken from the introduction to this book. The author, professor emeritus of Medical Oncology, reviews all aspects of the problem of cancer from a historical perspective, from the oldest existing records to the latest scientific and medical advances. It will interest the many people engaged in the treatment of cancer to read how the current therapeutic methods came about, and the book may also provide inspiration for cancer researchers, and for all those directly or indirectly involved with cancer. The layman looking for background information on a particular treatment may find it useful too. The various chapters can be read independently. A glossary and a few explanatory diagrams augment the text.This book grew out of an invitation the author received to lecture on the history of oncology. During his background reading, he discovered that there was no single volume dealing with the entire history of the subject. Fortunately, however, a great deal of information could be found here and there in the literature. As he read, he was struck by the fascinating stories behind many discoveries, and felt impelled to put them together in a single comprehensive account. The results of his labors are presented in this remarkable volume.The author, Prof. D.J.Th. (Theo) Wagener, was head of the department of Medical Oncology at the Radboud University Nijmegen Medical Centre in the Netherlands from 1982 to 2001, chairman of the Educational Committee of the European Society of Medical Oncology (ESMO), a member of the Educational Committee of the American Society of Clinical Oncology (ASCO) and a member of various international scientific working groups, mainly of the European Organization for Research and Treatment of Cancer (EORTC).Table of Contents1. Introduction.- 2. The occurrence of cancer in ancient times and the development of ideas about the nature of the complaint.- 3. The treatment of cancer in the past.- 4. The maturing of surgery as a treatment for cancer.- 5. The historical development of radiotherapy.- 6. The development of chemotherapy.- 7. The history of the hormonal treatment of cancer.- 8. The background of targeted therapy and the emergence of a new approach.- 9. Immunotherapy in the past and the present.- 10. The origins of psycho-oncology.
£999.99
Springer Trends in Stem Cell Proliferation and Cancer Research
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£170.99
Springer Central Nervous System Leukemia: Prevention and Treatment
Book SynopsisIn the past 10 to IS years there has been dramatic improvement in the survival of children with acute lymphoblastic leukemia. At the present time, over 50% of children with this disease will be alive and free of their disease at least 5 years from the time of their initial diagnosis. Although a number of factors have contributed to this improvement, perhaps none has been as important as the institution of central nervous system preventive therapy (eNS prophylaxis). However, despite the efficacy of eNS prophylaxis, the prevention and treatment of central nervous system leukemia continues to pose a formidable clinical challenge to the pediatric oncologist. Although successful in most cases, eNS preventive therapy remains ineffective for a small but significant subset of patients at high risk for developing eNS disease. Moreover, it has become increasingly evident that some methods of eNS preventive therapy are associated with long-term, adverse eNS sequelae. Thus, considerable controversy exists regarding the optimal method of eNS prophylaxis. Treatment of the patient who develops overt meningeal leukemia has not been as successful and continues to pose a major clinical challenge. Despite the ability of intrathecal chemotherapy and/or radiation therapy to induce eNS remission, most patients suffer subsequent relapse and ultimate survival is usually signifi cantly compromised. It is evident that newer approaches to treatment for this patient group must be identified before major improvement for this patient group is likely to occur.Table of Contents1. The Pathology of Central Nervous System Leukemia.- 2. Radiation Therapy Methods for Central Nervous System ‘Prophylaxis’ in the Management of Childhood Leukemias.- 3. Central Nervous System Prophylaxis for Therapy of Acute Lymphocytic Leukemia.- 4. Reduction in Central Nervous System Leukemia with a Pharmaco-kinetically derived Intrathecal-Methotrexate Dosage Regimen.- 5. Central Nervous System Prophylaxis with Intermittent Intrathecal Methotrexate and Fractional Radiation in Childhood Acute Lymphoblastic Leukemia.- 6. Intermittent Intrathecal Methotrexate and Fractional Radiation plus Chemotherapy in Childhood Lymphoblastic Leukemia.- 7. Prophylaxis of Central Nervous System Leukaemia: British Experience, 1970–80.- 8. The Norwegian Methotrexate Study in Childhood Acute Lymphocytic Leukemia.- 9. Therapy Related Central Nervous System Diseases in Children with Acute Lymphocytic Leukemia.- 10. Neurotoxic Complications of CNS Prophylaxis in Childhood Leukaemia.- 11. Evaluation of Adverse Sequelae of Central Nervous System Prophylaxis in Acute Lymphoblastic Leukemia.- 12. Adverse Sequelae of Central Nervous System Prophylaxis in Acute Lymphoblastic Leukemia.- 13. Treatment of Overt CNS Leukaemia.- 14. Radiation Therapy Methods for the Treatment of Central Nervous System Leukemia.- 15. Treatment of Meningeal Leukemia: Investigation of New Approaches with Conventional Agents.
£44.99
Springer Magnetic Resonance Imaging of Bone and Soft Tissue Tumors and Their Mimics: A Clinical Atlas
Book SynopsisMagnetic resonance imaging has already become a most valuable imaging modality in the diagnostic work-up of musculoskeletal neoplasms. While high accuracy of MRI for staging purposes has been proven, we will focus in this monograph on the characterization of primary bone and soft tissue tumors by MRI. The major purpose of this monograph is to provide an atlas of magnetic resonance features of primary bone and soft tissue tumors for radiologists, orthopedic surgeons and physiotherapists. The results presented are based on investigations of 94 primary bone and soft tissue tumors and mimicking conditions by magnetic resonance imaging. Although the scale of the material allows for statistical handling, the number of patients per subgroup is too small to come to definite conclusions. We will therefore limit ourselves to the description of and comments on a great number of cases to illustrate the diagnostic potential of this new imaging modality. We would like to thank the anonymous cooperators: referring clinicians, pathologists, nurses, technicians and secretaries whose help enabled us to present this monograph. We would also like to express our gratitude to the firms Siemens AG and Schering AG for technical support.Table of Contents1 General Considerations about Bone and Soft Tissue Tumors.- 2 Materials and Methods.- Benign Bone Tumors and Mimicking Conditions.- 3 Osteoid Osteoma.- 4 Enchondroma.- 5 Osteochondroma.- 6 Giant Cell Tumor.- 7 Vertebral Hemangioma.- 8 Solitary Bone Cyst.- 9 Aneurysmal Bone Cyst.- 10 Non Ossifying Fibroma.- 11 Eosinophilic Granuloma.- 12 Fibrous Dysplasia.- 13 Osteomyelitis.- Malignant Bone Tumors.- 14 Osteogenic Sarcoma.- 15 Chondrosarcoma.- Benign Soft Tissue Tumors.- 16 Lipoma.- Neurogenic Tumor.- Soft Tissue Hemangioma.- Aggressive Fibromatosis.- Malignant Soft Tissue Tumors.- 17 Liposarcoma.- 18 Malignant Fibrous Histiocytoma.- 19 Rhabdomyosarcoma.- 20 Value of Contrast (Gd-DTPA)-Enhanced MRI Studies in Cases of Musculoskeletal Tumors.- 21 General Conclusions.
£40.49
Springer New Trends in Gastric Cancer: Background and Videosurgery
Book SynopsisDespite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery". During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and Japanese experience. Because of the poor prognosis of gastric carcinoma there is increasing pressure for early detection. Some of the problems in the early detection of gastric carcinoma are discussed together with methods of surveillance of high-risk subjects. It is generally accepted that the surgical approach to gastric carcinoma should take into account the site and extent of the lesion and there are chapters on new methods for pre and intraoperative staging of the disease which allow a more logical approach to surgery. A comparison between Japanese and Western rule and results was attempted and reasons for the differences were investigated. Since the field is still evolving not all aspects could be covered, and those angles not approached in this book will be addressed in a second International Conference to be held in Rome in June 1990.Table of ContentsSection 1 Background.- 1 Epidemiology and machanism of gastric carcinogenesis.- 2 Histiogenesis and precursors of human gastric cancer.- 3 N-nitroso compounds, gastric carcinogenesis and chemoprevention.- 4 Analytical problems in the determination of N-nitroso compounds in gastric juice.- 5 Early detection of patients at high risk of developing gastric cancer.- 6 Prospects for early detection of gastric cancer and precancerous lesions.- Section 2 New Trends in Diagnosis.- 7 New trends in electronic videoendoscopy of the digestive tract.- 8 Endosonography: its diagnostic utilities for gastric cancer.- 9 Flow cytometry in gastric cancer.- Section 3 Surgical Treatment of Gastric Cancer.- 10 Intraoperative staging in gastric cancer surgery.- 11 New technologies in gastric cancer surgery: Computer system to make operation plan and intraoperative staining of regional lymph nodes for complete dissection.- 12 The general rule of the Japanese Research Society for Gastric Cancer and treatment results by the rule.- 13 A European multicentre retrospective study in cancer of stomach.- 14 Surgical treatment of gastric cancer: our elective procedures for desirable curability.- 15 “Regional” gastrectomy.- 16 Total gastrectomy in the surgical treatment of gastric cancer.- 17 The role of extensive surgery in advanced gastric cancer.- 18 The importance of extended lymphadenectomy in gastric cancer surgery.- 19 Duodenopancreatectomy for gastric cancer.- 20 Reconstruction after total gastectomy.
£116.99
Springer Minimal Residual Disease in Acute Leukemia 1986
Book SynopsisRelapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica tion in the detection of MRD are reviewed. In this respect, modern cyto genetics provide highly specific tumor markers. The resolution of cyto genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti bodies are also presented.Table of ContentsI — Detection of Minimal Residual Disease in Acute Leukemia.- New possibilities for cytogenetic analysis of leukemic cells.- Breakpoint analysis in CML: potentials for detection of minimal residual disease.- The mammalian ETS genes: two unique chromosomal locations in cat, mice and man and novel translocated position in human leukemias.- Activated RAS oncogenes in acute leukemia.- DNA rearrangements as unique markers of clonal evolution, recurrence and translocation.- The application of monoclonal antibodies for the detection and classification of AML.- Towards detection of minimal disease: discrimination of AML precursors from normal myeloid precursors using a combination of surface makers.- An immunological approach to analyse the kinetics of minimal residual disease in acute leukemia.- Visualization of minor cell populations with simultaneous three-parameter flow cytometry: BN rat marrow and spleen model.- Growth kinetics of minimal residual disease in the brown Norway rat acute myelocytic leukemia.- Detection of minimal residual acute lymphoblastic leukemia by immunological marker analysis: possibilities and limitations.- Surveillance of terminal deoxynucleotidyl transferase-positive cells in peripheral blood of patients with acute lymphoblastic leukemia.- In vitro colony forming cells of acute lymphoblastic leukemia: analysis of 24 cases with recombinant interleukin 2 as growth stimulus.- II — Intensive Chemotherapy Regimens for ‘Minimal Residual Disease’ in Acute Myeloblastic and Lymphoblastic Leukemia.- Biologic and treatment determinants of curability in acute myologenous leukemia.- High-dose cytosine-arabinoside plus AMSA for reinduction or consolidation-maintenance in acute myelogenous leukemia.- Treatment of residual disease in AML: interim analysis of a southeastern cancer study group prospective randomized clinical trial.- L-20 protocol for adult patients with acute lymphoblastic leukemia: a protocol utilizing prognostic factors, intensive chemotherapy and autologus “purged” marrow transplantation to eradicate minimal residual disease.- Treatment of minimal residual disease in adult ALL: the German national study.- Treatment of minimal residual disease in “poor risk” acute lymphoblastic leukaemia with high-dose cytosine arabinoside.- III Autologous Bone Marrow Transplantation for the Eradication of ‘Minimal Residual Leukemia’.- Autologous bone marrow transplantation in first remission AML using non-purged marrow — update.- Double autografting: a potential curative regimen for acute leukaemia?.- Autologous bone marrow transplantation in acute nonlymphocytic leukemia. A study of ex vivo marrow treatment with 4-hydroperoxycyclophosphamide.- Attempts to eliminate residual acute myeloid leukemia from autologous bone marrow grafts through in vitro chemotherapy — a review.- Monoclonal antibody purged autologous bone marrow transplantation for relapsed non T-cell acute lymphoblastic leukemia.- Allogeneic and autologous marrow transplantation: ex vivo purging with monoclonal antibody or immunotoxins to remove leukemic cells or to prevent graft versus host disease.- Detection and selective destruction of tumor cells by the lipophilic dye, merocyanine 540.- IV Allogeneic Bone Marrow Transplantation for the Eradication of ‘Minimal Residual Leukemia’.- Factors influencing long-term leukemia-free survival after allogeneic bone marrow transplantation for acute leukemia.- Bone marrow transplantation with HLA identical donors in the acute leukemias — Baltimore experience.- Results of allogeneic marrow transplantaton in patients transplanted for acute leukemia: a long-term follow-up.- Bone marrow transplantation in first CR of acute leukaemia using T-depleted marrow from HLA identical sibling donors.- Soybean lectin agglutination and E-rosette depletion for removal of T-cells from HLA-identical marrow grafts: results in 60 consecutive patients transplanted for hematologic malignancy.- Allogeneic bone marrow transplantation in adult leukemia: result of T-cell depletion by soybean lectin fractionation.- Rapid lymphocyte depletion by a new elutriator rotor for the prevention of acute graft versus host disease after allogeneic bone marrow transplantation.- Problems and prospect of histoincompatible bone marrow transplantation studied in rhesus monkeys.- Allogeneic marrow transplantation for the treatment of leukemia. Role of the major histocompatibility complex.- Summing up.- Minimal residual disease in leukemia: 1986.- Index of subjects.
£161.99
Springer Minimal Residual Disease in Acute Leukemia
Book SynopsisThe objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal cells in the marrow cavities. These methods are the first steps to the realization of the therapeutic goals indicated above. They include the production and ap plication of monoclonal antibodies against differentiation antigens on the cell sur face, the use of pulse cytophotometry - and cell sorter techniques, the employment of cytogenetics, the development of culture techniques for selective growth of precursor cells and several others. These methodologies offer prospects for refined diagnosis and, as far as the elimination of leukemic cells is concerned, the further development of autologous bone marrow transplantation. Eliminating tumor cells from autologous grafts requires the detailed knowledge of the cellular inter relationships within the neoplasm so that the neoplastic cells responsible for tumor propagation are specifically removed. Recognition and characterization of the clonogenic cells of the neoplasm should then lead to determining their sensitivity to the therapeutic agents which are clinically applied.
£44.99
Springer A short history of breast cancer
Book SynopsisThe Third Breast Cancer Working Conference of the Breast Cancer Cooperative Group of the European Organization for Research on Treatment of Cancer, to be held in Amsterdam on April 27-29, 1983, was the principle motive for writing this book. It was feh that a short review of the main pathogenetic conceptions and therapeutic principles which have presented themselves with regard to mammary cancer in the Course of Western history , might help to draw a more complete picture of where we stand today. It is not easy to decide which ideas, although discarded, deserve yet to be remembered and which authors from the past may be considered to be truly representative of the scientific climate of their age. Twenty centuries have produced quite a lot of ideas and the number of medical authors who advanced, or rejected, or modified, or revived them, is really uncountable. So the historian has to make a selec tion and choices are perforce subjective and open to criticism. In writing this book I tried to consult original sources in the original language as much as possible. These sources were not always strictly medical since I aimed at placing the problem of malignant breast disease - which might serve as a paradigm of cancer in general - in a somewhat wider context. For the history of medicine is not only a history of ideas, but also that of people, of institutions, of society.Table of Contents1. Antiquity.- 2. The Middle Ages.- 3. The Renaissance.- 4. Pathophysiological concepts in the Age of Enlightenment.- 5. Diagnosis and therapy in the eighteenth century.- 6. Europe during Napoleon and after.- 7. Scientific developments in the second half of the nineteenth century.- 8. Mammary carcinoma in the light of new developments.- 9. Surgical treatment in the second half of the nineteenth century.- 10. The twentieth century.- Epilogue.- Notes.- Index of names.
£40.49
Springer Multidisciplinary Management of Liver Metastases in Colorectal Cancer: Early Diagnosis and Treatment
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£116.99
Springer Retroperitoneal Tumors: Clinical Management
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£999.99
World Scientific Publishing Co Pte Ltd Abcs Of Cancer, The: Separating The Facts From
Book SynopsisThis exciting reader-friendly book addresses the general perspectives of cancer in diverse ways — everyday lifestyle, nutrition, environmental factors as well as genetics. The author, an expert in Immuno-Oncology, makes conscious efforts to break down the complexities of cancer development through the use of scientific evidences and everyday activities. There are so many myths about cancer out there. This book employs scientific basis to separate the facts from the myths while making it comprehensible to all readers irrespective of their scientific background. Readers are also introduced to the modern trends in cancer therapeutics.
£52.25
World Scientific Publishing Co Pte Ltd Evidence-based Clinical Chinese Medicine - Volume
Book SynopsisThis eighteenth volume of the Evidence-based Clinical Chinese Medicine series aims to provide a multi-faceted 'whole evidence' analysis of the management of pain due to a range of cancers (cancer pain) using integrative Chinese medicine.Beginning with an overview of how cancer pain is conceptualised and managed in conventional medicine, the authors then summarise the differential diagnosis and managment of cancer pain in contemporary Chinese medicine based on clinical guidelines and contemporary books. The third chapter provides detailed analyses of how cancer pain and related disorders were treated with herbal medicine and acupuncture in past eras based on the classical Chinese medical literature.The subsequent chapters comprehensively review the current state of the clinical trial evidence for the integrative application of Chinese herbal medicines (Chapter 5), acupuncture (Chapter 7), other Chinese medicine therapies (Chapter 8) and combination Chinese medicine therapies (Chapter 9) in the management of cancer pain, as well as analyse and evaluate the results of these studies from an evidence-based medicine perspective. Chapter 6 reviews and summarises experimental evidence for the bioactivity of commonly used Chinese herbs and their constituent compounds. The outcomes of these analyses are summarised and discussed in Chapter 10 which alsoidentifies implications for the clinical practice of Chinese medicine and for future research.This book can inform clinicians and students in the fields of integrative medicine and Chinese medicine regarding contemporary practice and the current evidence base for a range of Chinese medicine therapies used in the management of cancer pain, including herbal formulas and acupuncture treatments, in order to assist clinicians in making evidence-based decisions in patient care. It also provides researchers with a comprehensive summary of the state of the field than can inform future.The following features mark the importance of this book in the field:Table of ContentsEvidence-Based Chinese Medicine; Classical Chinese Medicine Literature for Cancer Pain and Associated Disorders; Contemporary Clinical Management of Cancer Pain with Integrative Chinese Medicine; Assessment of the Clinical Trial Evidence for Chinese Herbal Medicine, Acupuncture Therapies, Remedial Massage, and Combinations of Chinese Medicine Therapies in Integrative Cancer Pain Management;
£52.25
Springer Verlag, Singapore Personalized Management of Gastric Cancer: Translational and Precision Medicine
Book SynopsisThis book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment.The book’s four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors’ experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.Table of ContentsMolecular pathology of hereditary gastric cancer.- Genetics and molecular signature of gastric cancer.- Circulating tumor cells in gastric cancer.- Customized chemotherapy in advanced gastric cancer.- Targeted therapy in advanced gastric cancer.- Laparoscopic surgery and robotic surgery.- Radiotherapy in peritoneal metastatic gastric cancer.- Personalized intraperitoneal strategy in gastric cancer.- Checkpoint blockade therapy of gastric cancer.- Adoptive cell therapy of gastric cancer.- Combinational immunotherapy of gastric cancer.- Use of Nanomedicine in the diagnosis of gastric cancer.- Systemic drug delivery.- Local drug delivery.- Drug delivery in synergistic combination with other treatments.
£98.99
Springer Verlag, Singapore Lynch Syndrome: Molecular Mechanism and Current Clinical Practice
Book SynopsisThis book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease’s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.Table of Contents1 Molecular mechanism of Lynch syndrome 2 Clinical features of Lynch syndrome 3 Pathology of Lynch syndrome-associated tumors 4 Immunohistochemistry for mismatch repair proteins 5 Genetic analysis for Lynch syndrome 6 Lynch syndrome-associated gynecological malignancies 7 Lynch syndrome-associated urological malignancies 8 Screening for Lynch syndrome 9 Surveillance Colonoscopy for Lynch Syndrome Patients 10 Surgical approach for colorectal cancer in patients with Lynch syndrome 11 Immunotherapy for Lynch syndrome patients 12 Chemoprevention for Lynch syndrome-associated malignancies 13 International collaboration for Lynch syndrome
£999.99
Springer Verlag, Singapore Clinical Molecular Diagnostics
Book SynopsisThis book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.Table of ContentsPart I Principles of Clinical Molecular DiagnosticsChapter 1 Molecules of Diseases and Their Detection Methods Chapter 2 Assay Performance Evaluation Chapter 3 Establishment of Biological Reference Interval Chapter 4 Ethics: Informed Consent, Patient Privacy Chapter 5 Bioinformatics Chapter 6 Report and Consultation Chapter 7 Factors Associated with Variation Chapter 8 Quality Control and Quality Assurance Chapter 9 Precision Medicine Part 2 Molecular Biomarkers and Signals from Diseased Functional Organ Chapter 10 Molecules in Body Systems Chapter 11 Molecules in Signal Pathways Chapter 12 Endocrine and Metabolism Chapter 13 Immune System Chapter 14 Lipoproteins Chapter 15 Transport and Carrier Proteins Chapter 16 Coagulation and Fibrinolysis Chapter 17 Cardiovascular System Chapter 18 Pregnancy Chapter 19 Urine Chapter 20 Bone Chapter 21 Cancer Chapter 22 Translation Research of Novel Biomarker Part 3 Advanced Molecular Diagnostic Techniques Chapter 23 Next-generation Sequencing (NGS) Chapter 24 Digital PCR Chapter 25 Biosensor Chapter 26 Microfluidic Chip Chapter 27 Liquid Biopsy Chapter 28 Molecular Targeted Imaging Chapter 29 Fluorescence in Situ Hybridization Chapter 30 Circulating DNA Quantification Chapter 31 DNA Methylation Detection Techniques Part 4 Disease Presentation and Clinical Laboratory Procedures Chapter 32 Immunological Disorders Chapter 33 Liver Diseases Chapter 34 Pancreatic Diseases Chapter 35 Digestive Tract Disease Chapter 36 Kidney Diseases Chapter 37 Cardiovascular Disease Chapter 38 Lung Disease Chapter 39 Blood Disorders Chapter 40 Endocrine and Metabolic Diseases Chapter 41 Neurological Disease Chapter 42 Reproductive Organ Cancer Chapter 43 Reproductive Organ Cancer Chapter 44 Transplant Matching Chapter 45 Paternity Test
£132.99
World Scientific Publishing Co Pte Ltd Handbook Of Photodynamic Therapy: Updates On
Book SynopsisThe main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.Table of ContentsPart 1: Multifunctional Agents for Cancer-Imaging and Photodynamic Therapy: Monomers vs. Polyacrylamide-Based Nanoplatforms (Aimee Marko, Nayan J Patel, Penny Joshi, Joseph R Missert and Ravindra K Pandey); Design and Synthesis of Photosensitizers-peptide conjugates for PDT (Turslai M Williams, Martha Sibrian-Vazquez and M Graca H Vicente); Current Devcelopments in Using Meso (tetra) Substituted Porphyrins in PDT (Yasser M Shaker, Ayman M K Sweed, Claire Moylan, Luke Rogers, Aoife A Ryan, Rosine Petitdemange and Mathias O Senge); (Mike Detty et al.); Phthalocyanines in Cancer-Imaging and Therapy (Hasrat Ali and Johan E van Lier); Molecular Phthalocyanines-Based Photosensitizers for Photodynamic Therapy (Pui-Chi Lo, Sun Y S Chow and Dennis K P Ng); Porphyrin Nanoparticles for cancer Imaging and Photodynamic Therapy (Liyang Cui, Juan Chen and Gang Zheng); Photodynamic Therapy Dosimetry: A to Z (Michael S Patterson); Part 2: PDT: Death and Survival Pathways (David Kessel); Vascular Effect of Photodynamic Therapy of Tumors (Keith A Cengel, Charles B Simone and Theresa M Busch); ETNBS in Photodynamic Therapy (Nicholas H Nowell, Hsin-I Hung, Lauren A Austin and Conor L Evans); Negative Impact of Tumor-Generated Nitric Oxide on Photodtynamic Therapy (Albert W Girotti); On the use of Photodynamic Therapy, as Monotherapy or in Combination, in the Treatment of Polypoidal Choroidal Vasculopathy: an Update (Hubert van den bergh and Patrycja Nowak-Sliwinska); Part 3: Photodynamic Therapy of Head and Neck Cancer - What's Old and What's New (Merrill A Biel); Endoscopic Photodynamic Therapy for Advanced Inoperable Esophageal Cancer; PDT for Lung Cancer (Keishi Ohtani and Norihiko Ikeda); New Developments in Antimicrobial PDT (Wolfgang Baumler by Joerg Lindenmann);
£161.10
Springer Verlag, Singapore Methods in Cancer Stem Cell Biology
Book SynopsisThis book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. Table of Contents1. On the origin of cancer.- 2. Culture of Cells: Basic Principles .- 3. Stem cell culture from embryos.- 4. Reprogramming of normal cells.- 5. Maintenance of human Pluripotent Stem Cells.- 6. Identification of cancer stem cells by different molecular markers .- 7. Enrichment of Cancer Stem Cell from malignant tumor.- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line .- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells.- 10. Quick method to assess non-mutagenic carcinogens with iPS cells.- 11. Self-renewal potential of caner stem cells.- 12. Differentiation potential of cancer stem cells in vitro.- 13. Tumor Angiogenesis by cancer stem cells in vivo.- 14. Invasion and Metastatic potential of cancer stem cells in vitro.- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro .- 17. Tumorigenic potential of cancer stem cells in vivo.- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells .- 19. In-vitro evaluation of anti-cancer stem cell drugs .- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
£104.49
Springer Verlag, Singapore Interpretation of Gastric Cancer Cases
Book SynopsisThis book covers the diagnosis and treatment of various types of gastric cancer, and details the clinical process of gastric cancer treatment. Authors collects 37 clinical cases, which are typical gastric cancer cases with complicated disease or metastasis. In each case, the patient's gastroscopic results, abdominal CT images, pathological results and treatment process were analysed in detail. Combined with the expert's precise comments, the surgical treatment method and postoperative radiotherapy and chemotherapy and other treatment schemes of each case were clearly explained in an orderly manner.Table of ContentsThe surgical management of the early gastric cancer.- The minimally invasive surgery for gastric cancer.- Special type of surgical resection for gastric cancer.- The management for the complications associated with gastrectomy.- The comprehensive treatment for gastric cancer.
£999.99
Wolters Kluwer Health Understanding Kidney Cancer Anatomical Chart
Book SynopsisUnderstanding Kidney Cancer, Second Edition, is a highly illustrated, user-friendly chart that explains the role of the kidneys and defines kidney cancer. Now fully up to date with current guidelines, this second edition covers anatomy, stages of kidney cancer, risk factors, treatment options, and much more. Revisions reflect the many new drugs available for kidney cancer.Featured sections: Overview Risk Factors Signs and Symptoms Diagnosis Staging Treatments Prevention Illustrations included: Cross-section of the kidney and adrenal gland with all structures labeled Kidneys and surrounding veins and arteries in the context of body Large, detailed, and annotated illustrations of stages I through IV of kidney cancer 20" x 26" heavy paper laminated with grommets at top corners
£28.04
Wolters Kluwer Health Understanding Lung Cancer Anatomical Chart
Book SynopsisUnderstanding Lung Cancer, Second Edition, defines lung cancer and describes the two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Fully up to date with current guidelines, the chart describes how lung cancer is diagnosed and staged and lists risk factors, signs and symptoms, and treatment options. The main lung image shows the left upper lobe and left lower lobe with metastasis to paratracheal lymph nodes, metastasis to carinal lymph nodes, and a close-up, inset image of a tumor projecting into bronchi. The chart also describes how lung cancer can be prevented, includes a graphic showing how to calculate number of “pack years” along with an image of a cigarette in ashtray and the statistic that approximately 90 percent of lung cancer deaths are related to smoking. Featured sections: Risk Factors Signs and Symptoms Risk Factors Diagnosis and Staging Treatment Options How Can Lung Cancer Be Prevented? What’s a Pack Year? 20" x 26" heavy paper laminated with grommets at top corners
£28.04
