Medicine: Allergies Books

Book SynopsisThe Anti-Inflammatory Cookbook lays the foundation for understanding the relationship between inflammation and diet.Diseases such as cancer, diabetes, arthritis, and heart disease might cause discomfort through inflammation; this book helps you reduce and manage inflammation by being prepared, having helpful equipment, and maintaining the right mindset.Inside, you will find: Recipes for snacks, sides, meals, and desserts that will keep your mind and body feeling good Tools and techniques for using a slow cooker, air fryer, blender, and more in order to prepare a great meal A foundation for understanding the relationship between inflammation and diet Tips for choosing quality ingredients to make a delicious meal without compromising taste, texture, or nutrition A complete guide on how to focus on fruits and vegetables, whole grains, plant-based proteins, fatty fish, and other ingredients high in natural antioxidants and polyphenols, including coffee. The Anti-Inflammatory Cookbook makes clear that when you eat better, you feel better!

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Book SynopsisWhen Corin and Brian Mullins started their company, HapiFoods, in 2009 with just $129, they had no idea that in less than a decade they would be shipping millions of bags of cereals around the world. They just wanted to make a nourishing product that would both taste good and be compatible with Brian''s food allergiesand perhaps sell it locally for a bit of extra retirement income. After much experimentation, Corin came across the tiny black chia seeda complete protein, rich in omega 3 fatty acids as well as minerals, antioxidants and fibre. Corin blended chia with nutrient-rich buckwheat and hulled hemp seeds and, inspired by an enthusiastic comment from one of their first customers, she and Brian decided to label their first creation "Holy Crap, the World''s Most Amazing Cereal." Thanks in part to an appearance on the hit CBC show Dragons'' Den, their products gained the attention of Canadian consumers, many of whom became loyal customers.Starting with HapiFoods'' cereals and adding other healthy ingredients, this inspirational cookbook emphasizes a plant-based, gluten-free diet and includes over 60 simple-to-prepare but simply awesome recipes that harness the power of superfoods. From protein-packed breakfast fare like refreshing smoothies and perfect pancakes, to satisfying savory dishes and decadent desserts that don''t sacrifice nutrition for flavour, all the recipes in The Holy Crap Cookbook are in keeping with the Holy Crap philosophy: what you eat should be good for you and taste great.

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Book SynopsisThe revolutionary, research-based programme for preventing, diagnosing and reversing food allergies The problem of food allergy is exploding around us: an estimated 2 million people are living with a diagnosed food allergy in the UK alone. This book offers the first glimpse of hope with a powerful message: you can work with your family and your doctor to eliminate your food allergy forever. Drawing on her trailblazing research at Stanford University and work with thousands of children with allergies, Dr Kari Nadeau reveals that food allergy is not a life sentence because the immune system can be retrained. Food allergies – from mild hives to life-threatening airway constriction – can be disrupted, slowed and stopped. The key is a strategy called immunotherapy (IT), the controlled, gradual reintroduction of an allergen into the body. Fully anglicised for UK readers, The End of Food Allergy makes Dr Nadeau's life-changing research accessible for parents, carers and professionals alike. Together with co-author New York Times bestselling author Sloan Barnett – herself a mother of two children with food allergies – she walks readers through every aspect of food allergy, offering a clear, supportive plan that readers can work with alongside a health care professional to break free from any kind of food allergy. Includes: · What to do, learn and ask following a food allergy diagnosis – and how to find the right treatment· The science behind immunotherapy and early introduction · How to gradually reintroduce foods not working for you and your family · Advice on what to eat during pregnancy to help your baby avoid developing food allergies· How to cope with the emotional toll of living with food allergy and eliminate all fearsClear, comprehensive and reassuring, The End of Food Allergy offers a life-changing, research-based programme to take the fear out of food and end food allergies in children and adults alike.Trade ReviewOur daughter's world changed dramatically after Dr. Nadeau successfully treated her life-threatening food allergy. If you suffer from food allergy, or have a loved one who does, this book is a must-read! * Nancy and Steve Carell *Kari Nadeau is a true pioneer: she has steered the allergy world out of the dark ages and into the light of scientific cures. For anyone who has suffered from food allergies or lived in fear of them, this book is a ray of hope. * Adam Grant, New York Times bestselling author of Originals and Give and Take *As a physician, I'm excited for the impact of Kari's work to unlock new treatments for deadly food allergies. As a mother of children with a history of food allergy, I am grateful for the hope that this book gives families — the hope that we no longer have to live their lives in fear of accidental exposure. Thank you Kari Nadeau for changing our world. * Priscilla Chan, MD; CEO, Chan Zuckerberg Initiative *

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Book SynopsisWhat is an allergy? What does it mean to be vegan? And how do people know what they can and can''t eat?Whether you have a diverse diet or know someone that does, find out about some of the smartest food swaps around in this series of clever cookbooks. Grab your apron and head to the kitchen it''s time to cook!

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Book SynopsisThere are all kinds of emergencies, and for some people, being ready for an emergency is part of their everyday life. In My Emergency, you will see a day in the life of a child who lives with a potential emergency. Learn about the condition, the warning signs and what you can do to help in an emergency.

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Book SynopsisMany of us are affected by allergies, from the dreaded hayfever - the scourge of the summer - to much talked-about food allergies such as lactose and gluten. Dr Mike Dilkes, one of Harley Street's top Consultant ENT Surgeons, reveals his top tips for living with and treating an allergy.- Find out the difference between a sensitivity, an intolerance and an allergy- Discover how allergies affect your body and why- Learn how to see through the hype and take control of your own symptoms- Prevent attacks and treat outbreaksWith a no-nonsense approach to this controversial topic, Stop Allergies from Ruining Your LIfe... The Easy Way provides a straightforward analysis ofthe latest scientific research, allowing you to live the life you want, whatever the season.

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Book SynopsisDermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.Trade ReviewFrom the reviews:“New technological advances, new information in the field of cellular immunity and immunopharmacology in relation to skin diseases are reviewed in 4 large sections. … For teaching and practicing dermatologists and immunologists.” (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)Table of ContentsConcepts of Fundamental Importance for Understanding Skin Disease.- Cytokines and Chemokines.- Innate and Adaptive Immunity.- Neuroimmunology.- Stress and Immunity.- Toll-Like Receptors.- Conventional and Unconventional T Cells.- Complement System.- Cutaneous Dendritic Cells in Health and Disease.- Antimicrobial Peptides.- Photoimmunology.- Angiogenesis for the Clinician.- Common Skin Diseases.- Contact Dermatitis: Allergic and Irritant.- Atopic Dermatitis.- Psoriasis.- The Immunology of Acne.- Nonmelanoma Skin Cancer.- Immunobiology and Immune-Based Therapies of Melanoma.- Drug Eruptions.- Cutaneous Vasculitis.- Immunodermatology and Viral Skin Infection.- HIV Disease and AIDS.- Bacterial Infections.- Parasitic Infections.- Fungal Infections.- Cutaneous T-Cell Lymphoma.- Graft-Versus-Host Disease.- Allergic Urticaria.- Immunopharmacology.- Biologic Therapies for Inflammatory Disease.- Topical Immune Response Modifiers: Adjuvants.- Topical Immune Response Modifiers: Antiinflammatories.- Traditional Immune-Modulating Drugs.- Topical Corticosteroids.- Vaccines.- Intravenous Immunoglobulins.- Autoimmunity, Immunodeficiency, and Immune — Associated Dermatoses.- Novel Approach to the Evaluation of Primary Immunodeficiencies.- Iatrogenic Immunodeficiency and Skin Disease.- Granulomatosis.- Vitiligo Vulgaris.- Alopecia Areata.- Cutaneous Lupus Erythematosus.- Fibrotic Skin Diseases.- Pemphigus Family of Diseases.- The Pemphigoid Spectrum.- Epidermolysis Bullosa Acquisita.- Immunoglobulin A Dermatoses.

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Book SynopsisAllergies are increasing at a rapid rate and the team of experts behind Allergy Sense are here to break them down for families, ensuring people have up to date, and scientifically vetted, information. A lack of easily accessible and accurate information about particular allergies can exacerbate the anxiety of discovering a new food allergy or your child’s food allergy. Protecting your health, or your child’s health while also maintaining a level of ‘normality’ as a family can become an all-consuming focus. The authors of this book, an allergy specialist, a paediatric dietitian and an occupational therapist collaborate to unpack the difficulties in identifying specific allergies, prevent picky eating in children and guide you to live and eat as a family within the context of this challenge. As well as explaining the background and offering solutions Allergy Sense includes 70 delicious recipes for all the family to try at home. Chapters include:1. Demystifying allergies2. Is my child allergic?3. Emotions and the sensory world4. A look at ages and stages5. Adjusting to a new reality6. Living and thriving with allergies7. Recipes and meal plans8. Breakfasts9. Family meals10. Lunch boxes and snacks11. Desserts and parties12. Allergy action plan

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Book SynopsisEat Sweet, Savory, and Free with Debbie Adler's Mouthwatering Plant-Based Recipes, Free of the Top 8 AllergensIn 2013, Debbie Adler's Sweet Debbie's Organic Treats: Allergy-Free and Vegan Recipes From the Famous Los Angeles Bakery proved that cooking for those with allergies and food sensitivities doesn't mean giving up dessert.Now Sweet Debbie goes savory with more than 100 plant-based recipes free of the top eight food allergens—dairy, eggs, peanuts, tree nuts, soy, wheat, fish, and shellfish—plus free of refined sugar and oils.Motivated by her own son's life-threatening allergies, Adler has spent the last six years creating meals to nourish and delight her entire family—meals that are both savory and safe—including:Lemon Basil Blueberry MuffinsSweet Miso Forbidden Rice Ramen Noodle BowlRoasted Butternut Squash Enchilada RoundsYam Gnocchi with Sriracha PestoMediterranean Quinoa BurgersSpanakopita Enchiladas with Roasted Red Pepper Cream SauceCinnamon Raisin BreadCafe Macchiato Sandwich CookiesDebbie's super satiating, divinely delicious, and accessibly easy-to-prepare recipes show just how incredible, versatile, and flavorful allergy-free, plant-based cooking can be! Her entrees, pastas, soups, sides, breads, and sweets are a guaranteed—and guaranteed safe—hit for school, kids' parties, work events, and more.Trade Review"I have a big, loud, Italian family, and we love to eat. I also have a daughter and nephew with food allergies, so it can be tricky. Debbie Adler has found a way to make everybody happy. Sweet, Savory, and Free allows you to make everything from condiments to pizza to cookies, without using any of the eight top food allergens. The genius part? It's all delicious. My family doesn't know the difference, because believe me, if they did, I'd hear about it. Thank you, Debbie!" —Ray Romano "The way we eat has a profound effect on our health, and the health of the planet. Sweet, Savory, and Free is filled with recipes that will keep you (and our Mother Earth) from going into cardiac arrest . . . and did I mention that they're all delicious!" —Ed Begley, Jr., Emmy- and Golden Globe–award nominated actor and environmentalist "Sweet, Savory, and Free could easily qualify as an optimum health book, with an eye toward making tasty dishes. Your kitchen would not be complete without this book. Debbie Adler's personal motivation for this book is compelling." —T. Colin Campbell, PhD, coauthor of The China Study and the New York Times bestselling Whole "Sweet, Savory, and Free proves that allergen-free, healthful plant-based cooking can be delicious—and fun! Debbie Adler makes it possible to prepare wonderful worry-free dishes for anyone, anytime." —JJ Virgin, celebrity nutrition and fitness expert, and author of the New York Times bestselling books The Virgin Diet and Sugar Impact Diet "Debbie makes living plant-based and allergy-free delicious and fun with her super tasty and nutritious recipes. This book is an incredible resource for any family wanting to eat healthy." —Tess Masters, author of The Blender Girl, The Blender Girl Smoothies, and The Perfect BlendTable of ContentsINTRODUCTIONCHAPTER 1: Just HavesCHAPTER 2: Fully EquippedCHAPTER 3: Recipes within Recipes (Homemade Staples)CHAPTER 4: Morning MunchiesCHAPTER 5: Soup Is Good FoodCHAPTER 6: Meals in Muffin Tins and RamekinsCHAPTER 7: Pizza, Pasta, Rice, and NoodlesCHAPTER 8: The Main AttractionCHAPTER 9: The Side ShowCHAPTER 10: The Bread BasketCHAPTER 11: A Feast of SweetsRESOURCESACKNOWLEDGMENTSABOUT

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Book SynopsisThe fourth edition of this important book, which includes additional color illustrations, has been extensively revised, updated, and expanded to reflect the most recent developments. These include advances in patch testing methodology, in particular the new chambers that are appearing on the market, revision of the baseline series of patch tests to reflect the latest evidence-based work, and additional testing procedures. Other additions include sections on key allergens and concentrations, with the result is a superb guide to the current management of positive and negative patch test and prick test reactions that will be invaluable for all practicing dermatologists, from the beginner to the well-trained expert.The fourth edition continues the tradition of partnering with the ICDRG (International Contact Dermatitis Research Group). The ICDRG was formed in 1966 to promote the understanding of contact dermatitis. It has had major roles in the standardization of patch testing and the facilitation of regular scientific meetings, for over forty years and thirty five years respectively. It has also been involved in the authorship of a number of publications on contact dermatitis. Both Drs. Maibach and Lachapelle are members and the ICDRG is now comprised of representatives from all over the world, and currently includes members from Belgium, Sweden, Denmark, the United Kingdom, USA, Germany, Singapore, Korea, India, Japan, Canada, Uruguay and Australia.From the reviews of the previous editions:"The aim is to balance brevity and clarity with sufficient details for beginners in the field of diagnostic patch and prick testing. … the book also will be of use to dermatology residents or anyone wishing to gain better knowledge of contact dermatitis. … There are many high-quality photographs and useful algorithms and tables. … It is clearly and concisely written and will serve as an indispensable guide for any dermatologist interested in contact dermatitis." (Renata H. Mullen, Doody’s Review Service, August, 2009)Table of ContentsContentsIntroductory RemarksPart I Patch Testing1 Pathophysiology of Allergic and Irritant Contact Dermatitis 1.1 Introduction 1.2 Pathophysiology of Irritant and Allergic Skin Inflammation 1.2.1 Irritant and/or Allergic Chemicals 1.2.2 Skin Irritation: Activation of Innate Immunity 1.3 Skin Allergy: The Role of Specific Immunity 1.3.1 Antigen-Specific Immunity 1.3.2 Skin Allergy: Mechanisms of Action 1.3.3 Indirect Responsibility of Chemicals in Skin Irritation 1.4 Pathophysiology of Skin Inflammation: The Connection Between Innate and Acquired Immunity References 2 Diseases for Which Patch Testing Is Recommended: Patients Who Should Be Investigated2.1 Allergic Contact Dermatitis 2.1.1 Clinical Signs and Symptoms 2.1.2 Histopathological Features 2.2 Allergic Contact Dermatitis Syndrome 2.2.1 Stage 1 of ACDS 2.2.2 Stage 2 of ACDS 2.2.3 Stage 3 of ACDS 2.3 Allergic Contact Dermatitis Versus Irritant Contact Dermatitis: Criteria for Differential Diagnosis 2.4 Other Skin Diseases in Which Patch Testing Is of Major Interest 2.5 Algorithmic Approach: Key Role of Patch Testing 2.6 Hand Dermatitis: Definition and Procedures Applied in Differential Diagnosis 2.6.1 Hand Dermatitis: Exogenous and Endogenous Factors 2.6.2 A Classification of Hand Dermatitis 2.6.3 Tools of Investigation 2.6.4 Hand Dermatitis: Some Examples of an Algorithmic Approach 2.6.5 Hand Eczema: A Controversial Issue References 3 Patch Testing Methodology 3.1 Historical Background 3.2 Definition and Aims 3.2.1 Requirements for an Ideal Patch Testing Procedure 3.2.2 Is Patch Testing the “Gold Standard” to Investigate Patients with Allergic Contact Dermatitis? 3.3 Patch Test Units 3.3.1 Nonchamber Patch Tests 3.3.2 Chamber Patch Tests 3.3.3 Plastic Square Chambers 3.3.4 Reinforcement of Patch Test Units 3.4 A General Overview of Allergens 3.4.1 Allergens 3.4.2 Bioavailability of Allergens 3.4.3 Quality Control of Allergens 3.4.4 Appropriate Amounts of Petrolatum to Be Applied at Patch Testing 3.4.5 Appropriate Amounts of Liquids to Be Applied at Patch Testing 3.5 Specific Recommendations When Considering Patch Testing Patients 3.5.1 Patch Testing on Intact Skin Is Critical 3.5.2 Medicaments and Patch Testing 3.5.3 Pregnancy and Patch Testing 3.5.4 Patch Testing in Children 3.6 Application of Patch Tests on the Skin: Some Practical Suggestions 3.6.1 Test Sites 3.6.2 Removal of Hair 3.6.3 Degreasing of Test Site 3.6.4 Application of Test Strips 3.6.5 Instructions to Patients 3.7 Reading Time 3.7.1 Standard Patch Test Occlusion and Reading Time 3.7.2 Conventional Patch Test Reading Time 3.7.3 Reading at Day 2, Day 3, and Day 4 3.7.4 Reading at Day 7 3.7.5 Single Reading Versus Multiple Reading 3.7.6 Day 3 Versus Day 4 Reading 3.7.7 One-Day Occlusion Versus Two-Day Occlusion 3.7.8 Marking the Skin 3.7.9 Positive Control 3.7.10 Immediate Urticarial Reactions to Some Allergens 3.8 Reading and Scoring Patch Test Results 3.8.1 Scoring Codes According to the ICDRG 3.8.2 Proposal for Modified Scoring Codes of Positive Patch Test Reactions, According to ESCD and EECDRG 3.8.3 Rating Patch Test Reactions Based on Digital Images 3.8.4 Bioengineering Methods for Evaluating Skin Irritation and Allergic Reactions. A Comparison with Visual Scoring 3.8.5 Remarks About Reading and Scoring Patch Test Results 3.9 Irritant Patch Test Reactions 3.10 False-Positive Patch Test Reactions 3.11 False-Negative Patch Test Reactions 3.12 Compound Allergy 3.13 Cross-Sensitization, Concomitant Sensitization, and Polysensitization 3.13.1 Cross-Sensitization 3.13.2 Concomitant Sensitization 3.13.3 Polysensitization 3.14 Unwanted Adverse Reactions of Patch Testing 3.14.1 Patch Test Sensitization (“Active Sensitization”) 3.14.2 Excited Skin Syndrome (“Angry Back”) 3.15 Patch Test Readings in Different Ethnic Populations 3.15.1 Patch Test Reading in Oriental Populations 3.15.2 Patch Test Reading in Black Populations 3.16 Patch Testing Techniques in Different Climatic Environments 3.16.1 Temperate Climates 3.16.2 Tropical Climates 3.16.3 Patch Testing Procedures in the Tropics 3.17 Is Self-assessment of Allergic Contact Dermatitis by Patients Recommendable? 3.17.1 Self-assessment by Questionnaires 3.17.2 Self-readings of Patch Tests by Patients References 4 Baseline Series of Patch Tests 4.1 Historical Background 4.2 Advantages and Disadvantages of Using a Baseline Series of Patch Tests 4.2.1 Advantages 4.2.2 Disadvantages 4.3 The Different Baseline Series of Patch Tests 4.3.1 ICDRG-Revised International Minimal Baseline Series of Patch Tests 4.3.2 The Updated 2019 European Baseline Series on Behalf of the ESCD and EECDRG 4.3.3 The Updated 20109 North American Baseline Series on Behalf of the NACDG 4.3.4 The Updated 2019 Japanese Baseline Series on Behalf of the JCDS 4.4 “Mixes” of Baseline Series 4.5 Concise Information About Allergens Included in the Updated 2011 Minimal Baseline Series of the ICDRG4.6 Concise Information on Other Common Allergens Included in the Updated 2011 Minimal Baseline Series of the ICDRG 4.7 Additional Series of Patch Tests4.8 The Preservative Methylisothiazolinone : The New Star of Allergic Contact DermatitisReferences 5 Photopatch Testing 5.1 Definition and Aims 5.2 Photoallergic Contact Dermatitis 5.3 Photoallergic Contact Dermatitis Versus Airborne Allergic Contact Dermatitis: Criteria for Differential Diagnosis 5.4 Photoallergic Drug Eruptions 5.5 Photopatch Testing Methodology 5.6 Light Sources 5.7 Proposal for a Photopatch Test Series References 6 The T.R.U.E. Test® Methodology 6.1 Introduction 6.2 The T.R.U.E. Test® Methodology6.3 More Practical Information About the Technology of The T.R.U.E. Test® 6.4 Regulatory Information 6.5 Standard The T.R.U.E. Test® Series 6.6 New Additions 6.7 Methodology of Use 6.8 Additional Information6.9 Note References 7 Additional Testing Procedures and Spot Tests 7.1 Strip Patch Test 7.2 Open Test 7.3 Semi-open (or Semi-occlusive) Tests 7.4 Repeated Open Application Test 7.5 Testing Procedures with Unknown Substances 7.5.1 Strategy 7.5.2 Steps Required Prior to Any Testing Procedure 7.5.3 Testing Procedures with Solid Products and Extracts 7.5.4 The Use of Ultrasonic Bath Extracts in the Search of the Culprit(s) Allergen(s) present in Solid Products7.5.5 Testing Procedures with Cosmetics and Other Related Products7.6 Oral Provocation Test (Oral Challenge) 7.7 Other Investigations 7.7.1 pH Measurement 7.7.2 Spot Tests 7.7.3 Chemical Analysis 7.8 Additional Remarks About Chemistry and Immunology in Relationship with Allergic Contact Dermatitis References 8 Clinical Relevance of Patch Test Reactions 8.1 Introduction 8.2 General Principles 8.3 Past and Current Relevance 8.4 Scoring System 8.5 Strategies 8.5.1 Clinical History 8.5.2 Environmental Evaluation 8.5.3 Further Correlations 8.5.4 Additional Investigations 8.6 Suggestions for Improved Evidence-Based Diagnosis of Relevance 8.7 Additional Remark References 9 Atopic Dermatitis, Irritant Contact Dermatitis, and Allergic Contact Dermatitis 9.1 Preliminary Remarks9.2 Etiopathogenic Advances9.3 Disruption of the Skin Barrier9.4 Increased Disruption of the Skin Barrier in AD 9.5 Hand Eczema9.6 Other Skin Typical Locations of Lesions in AD 9.7 Guidelines for the Practice of Patch Testing References Part II Prick Testing10 Spectrum of Diseases for Which Prick Testing and Open (Non-prick) Testing Are Recommended: Patients Who Should Be Investigated 10.1 Contact Urticaria Syndrome 10.1.1 Clinical Symptoms and Stages of CUS 10.1.2 Etiology and Mechanisms of CUS 10.1.3 Contact Urticaria to Natural Rubber Latex 10.2 Protein Contact Dermatitis References 11 Methodology of Open (Non-prick) Testing, Prick Testing, and Its Variants 11.1 Introductory Remarks11.2 Open (Non-prick) Testing 11.3 Prick Test: Technical Modalities and Reading 11.3.1 Technique of Puncture 11.3.2 Control Solutions 11.3.3 Reading Time 11.3.4 Reading Prick Test Results 11.3.5 Medicaments and Prick Testing 11.3.6 False-Negative Reactions 11.3.7 False-Positive Reactions 11.3.8 Prick Tests in Children and Babies 11.4 Prick-by-Prick Test 11.5 Scratch Test 11.5 Scratch-Chamber Test 11.7 Comparative Indications of Open (Non-prick) Testing, Prick Testing, and Other Related Tests 11.8 Intradermal Testing for Type 1 Hypersensitivity 11.9 Prick Testing: Allergens of Interest for Skin Problems 11.9.1 Latex 11.9.2 Airborne Environmental per Annum Allergens 11.9.3 Airborne Environmental Seasonal Allergens 11.9.4 Food Allergens (Trophallergens) 11.9.5 Occupational Allergens 11.9.6 Fungi 11.9.7 Miscellaneous (Immunological and/or Non-immunological) Urticariogens References Part III Testing in Cutaneous Systemic Immune-Related Adverse Drug Reactions: Interest and Limitations12 Testing Procedures in Cutaneous Systemic Immune-Related Adverse Drug Reactions 12.1 General Considerations 12.2 Proposal of a Classification of CADR 12.3 Tools of Investigation in CADR 12.4 Histopathological Limitations in Diagnosis of a CADR 12.5 Patch Testing in CADR 12.5.1 Spectrum of CADRs for Which Patch Testing Is Recommended 12.5.2 Spectrum of CADRs for Which Patch Testing Can Be Performed (Being Still Controversial) 12.5.3 Spectrum of CADRs for Which Patch Testing Is of No Interest 12.5.4 Guidelines in Drug Patch Testing: General Rules 12.5.5 Technical Aspects of Drug Patch Testing 12.5.6 Readings of Drug Patch Tests 12.5.7 False-Negative Patch Test Reactions 12.5.8 False-Positive Patch Test Reactions 12.6 Prick Testing in CADR 12.7 Intradermal Testing in CADR 12.8 Oral Provocation Test (Oral Challenge) in CADR References Appendices Appendix A: Additional Series of Patch Tests A.1 Introductory Remarks A.2 Bakery Series A.3 Corticosteroid Series A.4 Cosmetic Series A.5 Epoxy Resin Series A.6 Hairdressing Series A.7 Isocyanate Series A.8 Metal Series A.9 (Meth)Acrylate Series A.10 Plastics and Glues Series A.11 Rubber Additives Series A.12 Textile Dyes and Finish Series A.13 Other Series References Appendix B: The International Contact Dermatitis Research Group B.1 Historical Background B.2 Current Tasks and Strategy of the ICDRG B.3 ICDRG Members References Appendix C: A List of Companies Producing and/or Distributing Patch and/or Prick Test Materials and/or Allergens C.1 Introductory Remarks C.2 List of Companies

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Book SynopsisThis easy-to-read title provides a comprehensive discussion of the major changes in daily life that have led to states of increased bodily inflammation. Indeed, today there is an epidemic of allergic and autoimmune disease in the first and developing world. While outdoor climate change is now considered common knowledge, the impact of longer work hours, artificial lighting, increased food shelf life, and changes to the microbiome all have made a large impact in increasing allergies worldwide. An allergy, best defined as a “damaging response from the Immune system due to a substance in the environment,” starts with warning signals, or generalized "symptoms," that are caused by something in the environment. Itching, aches, pains, swelling, coughing, and fatigue are all immune responses. Written in an engaging -- and often humorous -- style by an allergist/immunologist, the first three chapters outline how the human body is in an unquestionably harmful environment, and that, in general, the immune system is just doing its job. In subsequent chapters, the specific topics contributing to allergies are covered in detail, starting with microorganisms and a focus on indoor living. Dust mites, for example, are addressed in one full chapter -- and for good reason. The past few decades have seen an explosion of climate controlled, humidified indoor airspace that is ideally suited for more mass production of mites.In the end, emphasizes the author, all roads of inflammation from the environment lead to the “mast cell compartment.” The stress responses of the body summarily drive up this compartment and have led to a world-wide prevalence of between 14% to 17% of “mast cell activation syndrome.” While genetics and comorbid conditions are important in any symptom or disease process, the mast cell compartment feeds and grows off all the major environmental changes of the past 50 or so years. This is why the human body in the 21st century is in a low level state of “rejection,” of the world, says the author. Most of these changes are irreversible, but the situation is not hopeless. Understanding how the body changes itself in response to its environment will allow controlled desensitization to the environment. Allergic to Life: How the Human Body Rejects the Modern World serves as a concise and lively text for clinicians and general readers interested in a deep, expert dive into the world of allergy and immunology. Table of Contents

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Book SynopsisPreface.- Epidemiology of Allergic Diseases.- Basic Mechanisms of Allergy Diagnostics.- Principle of Allergy Diagnostics.- Asthma in the Pediatric Patient.- Severe Asthma in the Pediatric Patient.- Atopic Dermatitis in Pediatric Children.- Allergic Conjunctivitis in Children.- Allergic Rhinitis in the Pediatric Child.- Hymenoptera Venom Allergy in Children.- Anaphylaxis in Pediatric Patients.- Wheezing in Pediatric Patients.- Drug Allergy in Children.- IgE Mediated Food Allergy.- Non IgE Mediated Food Allergy.- Eosinophilic Esophagitis in Children.- Urticaria in the Allergic Child Minasi.- Allergic Angioedema in Pediatric Patients.- Allergy-related Eosinophilia in Children.- Mastocytosis in the Pediatric Patient.- Contact Dermatitis in Children.- Molecular Diagnosis in Pediatric Allergy.- Laboratory Tests in Pediatric Allergy.- Corticosteroids for Inflammation Control in the Allergic Child.- Biologics Monoclonal Antibodies in Pediatric Allergy Treatment.- Allergen-Specific Immunotherapy.- Vaccinations for Infective Diseases and Allergy.- Pollution, Climate Change and Environmental Allergy.- Daily Life of Allergic Children.- Allergy Prevention.- Subject Index.

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Book SynopsisTreat allergies naturally Written by a leading practitioner of the groundbreaking F.X. Mayr cure, which equates allergic reactions with poor digestive health and accumulated toxins, this new book discusses how this innovative approach can be applied to allergy treatment. This compact book is filled with numerous clinical examples and practical tips on improving treatment outcomes, and covers everything from the fundamental principles of allergy to the role of the digestive system. The full spectrum of the Mayr program is explored, including descriptions of water-tea fasting, milk-bread roll diets, patient training and education, practical tips for individual allergy symptoms such as migraine headaches and rheumatic complaints, and more! Here is the modern approach to treating allergic medicine using groundbreaking FX Mayr guidelines. Anyone interested in treating asthma and allergies naturally - pediatricians, general practitioners, internists, allergists, pulmonologists, and alternative medicine practitioners - will want this landmark text in their library.Table of ContentsIntroduction What's an Allergy? Digestion and Allergies Lymph System and Allergies F.X. Mayr Diagnostics Recognizing Allergies/Intolerance Allergy Therapy Opportunities Basic Principles of Modern Mayr Medicine Practical Tips for Allergy Treatment Conclusions for Everyday Life from the Ideas of Modern Mayr Medicine? Appendix

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Book SynopsisWhile first accounts of food allergy date back to antiquity, only in recent years has food allergy become recognized as one of the major allergic diseases. During the last decade the output of research papers on food allergy increased tremendously, and today, issues related to food allergies still attract a lot of attention among academics and the general public. Featuring contributions by world-renowned experts, this book presents the current concept, practice and recent advances in the field of food allergy. A comprehensive background section provides a historical retrospective and information on the immunological basis and epidemiology of food allergies. Main topics discussed include clinical aspects, diagnosis and management, allergen-based food allergies, and disease-based food allergies. Furthermore, nutritional aspects and diets, public policy and educational programs are covered as well as recent hot topics such as molecular-based allergen diagnosis, eosinophilic gastrointestinal food allergies and oral immunotherapy. Allergists, pediatricians, internists, dermatologists and general practitioners will find this publication an essential source of information as it provides in-depth insights into food allergies from childhood to adulthood.

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Book SynopsisDas Interesse an pulmonalen Erkrankungen, besonders an Asthma, hat sich in den vergangenen Jahren in erheblichem Maße verstärkt, bedingt durch Hinweise auf eine zunehmende Häufigkeit derartiger Krankheitsbilder und durch die Annahme eines Zusammenhanges mit den Umweltbedingungen in der Industriegesellschaft. Asthma ist eine vielschichtige Krankheit - Ätiologie, Pathophysiologie, Klinik und Befunde sind uneinheitlich - die in der verfügbaren Literatur in unterschiedlicher Weise abgehandelt wird. In diesem Buch beschreiben 26 Autoren das Krankheitsbild Asthma unter dem aktuellen Gesichtpunkt der Entzündung der Atemwege und der daraus resultierenden Hyperreagibilität. Der Schwerpunkt liegt dabei auf der nervösen und neurohumoralen Regulation, den Grundlagen der Hyperreagibilität sowie Diagnostik und Therapie. Das Buch ist sowohl für den niedergelassenen Arzt als auch den Krankenhausarzt eine umfassende Informationsquelle über das aktuelle Krankheitsbild.Table of Contents1 Definitionen.- 2 Epidemiologie.- 2.1 Prävalenz des Asthmas.- 2.1.1 Probleme der Datenerfassung.- 2.1.2 Asthma-Prävalenz — regionale Unterschiede.- 2.1.2.1 Großbritannien.- 2.1.2.2 Skandinavien.- 2.1.2.3 Mitteleuropa.- 2.1.2.4 Frankreich / Südeuropa.- 2.1.2.5 Vereinigte Staaten von Amerika.- 2.1.2.6 Australien, Neuseeland.- 2.1.2.7 Dritte Welt.- 2.1.3 Zusammenfassung der epidemiologischen Daten.- 2.1.4 Ursachen der Zunahme des Asthmas.- 2.1.5 Schlußfolgerungen.- 3 Morphologie.- 3.1 Morphologische Veränderungen bei Asthma.- 3.1.1 Grundzüge der morphologischen Veränderungen.- 3.1.2 Zellverbindungen im Oberflächenepithel.- 3.1.3 Struktur der feineren Innervation der Atemwegsschleimhaut.- 3.1.4 Anordnung der Mastzellen in der menschlichen Atemwegsschleimhaut.- 3.1.5 Morphologische Veränderungen im Asthmaanfall.- 3.1.6 Schlußfolgerungen.- 3.2 Mastzellen: Lokalisation, Funktion und Interaktion mit zellulären und nervösen Strukturen.- 3.2.1 Definition und Vorkommen der Mastzellen.- 3.2.2 Lokalisation und Verteilung der Mastzellen in den Atemorganen.- 3.2.3 Struktur und Funktion bronchialer Mastzellen.- 3.2.4 Interaktion von Mastzellen mit zellulären und nervösen Strukturen.- 3.2.5 Schlußfolgerungen.- 4 Immunpharmakologie.- 4.1 Induktion und Modulation der allergischen Reaktion.- 4.1.1 Grundlagen der Immunreaktion.- 4.1.2 Immunglobulin E (IgE).- 4.1.3 Klinische Bedeutung des Serum-IgE.- 4.1.4 Genetische Kontrolle des IgE.- 4.1.5 IgE-Bestimmungsverfahren.- 4.1.6 Biologische Funktion des IgE.- 4.1.7 Zelluläre und membranbiochemische Vorgänge bei IgE-abhängiger Antigen-Antikörperreaktion.- 4.1.8 Regulation der IgE-Synthese.- Anhang Immunologie-Glossar.- 4.2 IgE-Synthese.- 4.2.1 Grundzüge der IgE-Antikörper-Synthese.- 4.2.2 Regulation der IgE-Synthese beim Menschen.- 4.2.2.1 Die Wirkung des Pokeweed-Mitogens auf periphere Leukozyten.- 4.2.2.2 Die Wirkung von Interleukin (Il)-2 auf die IgE-Synthese beim Menschen.- 4.2.2.3 Der Bindefaktor für humanes IgE.- 4.2.2.4 Biologische Funktion der IgE-Bindefaktoren.- 4.2.3 Schlußfolgerungen: Zukünftige Entwicklung.- 4.3 Asthma als Entzündungsreaktion.- 4.3.1 Grundlegende Aspekte.- 4.3.2 Nachweis von Entzündungszellen und Mediatoren bei Asthma.- 4.3.3 Herkunft der Entzündungsmediatoren in der Lunge.- 4.3.4 Schlußfolgerungen.- 4.4 Lipidmediatoren.- 4.4.1 Immunbiologische Grundlagen der Entzündungsreaktion.- 4.4.2 Synthese von Lipidmediatoren durch Zellmembranaktivierung.- 4.4.3 Die Rolle von Enzymen bei Leukotrien-Induktion und-Metabolisierung.- 4.4.4 Biosynthese von PAF-Acether.- 4.4.4.1 Herkunft von PAF-Acether.- 4.4.5 Biologische Wirkung von Lipidmediatoren.- 4.4.6 Nachweissysteme für Leukotriene.- 4.4.6.1 Leukotriene in Plasma und bronchoalveolärer Lavageflüssigkeit.- 4.4.6.2 Aus peripheren Zellen freigesetzte Leukotriene.- 4.4.6.3 Biologische Funktion und Interaktion der Lipidmediatoren.- 4.4.7 Klinische Daten.- 4.4.8 Schlußfolgerungen.- 4.5 Chemotaktische Eigenschaften der Mediatoren.- 4.5.1 Histamin.- 4.5.2 Leukotaktische Peptide.- 4.5.3 Leukotriene und mono-HETEs.- 4.5.4 Prostaglandine.- 4.5.5 Der Thrombozyten-aktivierende Faktor (PAF-Acether).- 4.5.6 Anaphylatoxine.- 4.5.7 Zytokine und andere chemotaktische Faktoren.- 4.5.8 Allgemeines und Gemeinsames zur Funktion chemotaktischer Faktoren.- 4.5.8.1 Wirkung auf die Einzelzelle.- 4.5.8.2 Wirkung auf das Gewebe.- 4.5.8.3 Synergismus.- 4.5.8.4 Immunabwehr.- 4.5.8.5 Chemotaxis und Zellentwicklung im Knochenmark.- 4.5.9 Regulation der chemotaktischen Faktoren.- 4.5.9.1 Inhibition und Inaktivierung der Mediatoren.- 4.5.9.2 Sonderrolle der eosinophilen Granulozyten.- 4.5.10 Relative Wertung der chemotaktischen Faktoren bei Asthma.- 4.6 Kinine.- 4.6.1 Proteolytische Enzymkaskaden.- 4.6.2 Hageman-Faktor.- 4.6.3 Kinine.- 4.6.3.1 Biochemie.- 4.6.3.2 Physiologische Effekte des Kinins am Respirationstrakt.- 4.6.4 Kinine bei Asthma.- 4.6.5 Schlußfolgerungen.- 4.7 Zusammenfassung und Übersicht: Zellen und Mediatoren in der Pathogenese des Asthmas.- 5 Nervöse und neurohumorale Regulation.- 5.1 Adrenerge Rezeptoren: Funktion und Lokalisation.- 5.1.1 Rezeptorfunktion.- 5.1.2 Klassifikation adrenerger Rezeptoren.- 5.1.3 Molekulare Mechanismen der Signalaktivierung.- 5.1.4 Verteilung von adrenergen Rezeptoren.- 5.1.5 Adrenozeptordichte und physiologische Wirkung.- 5.2 Rolle nervöser und neurohumoraler Mechanismen bei Atemwegsentzündung und Hyperreagibilität.- 5.2.1 Bedeutung des autonomen Nervensystems bei Asthma.- 5.2.2 Aufbau des autonomen Nervensystems von Lunge und Atemwegen.- 5.2.2.1 Überträgersubstanzen des autonomen Nervensystems.- 5.2.2.2 Autonome pharmakologische Rezeptoren.- 5.2.2.2.1 Adrenerge pharmakologische Rezeptoren.- 5.2.2.2.2 Cholinerge pharmakologische Rezeptoren.- 5.2.3 Der „klassische“ Reflex.- 5.2.4 Interaktionen zwischen efferenten cholinergen Nerven und Mediatoren.- 5.2.5 Die integrative Funktion der Ganglien: Wirkung afferenter Impulse auf die ganglionäre Reizschwelle.- 5.2.6 Neuropeptide in afferenten Nerven: „neurogene Entzündung“ — nicht-cholinerges exzitatorisches System.- 5.2.7 Neuropeptide in efferenten Nerven: das nicht-adrenerge inhibitorische Nervensystem (NAIS).- 5.2.8 Schlußfolgerungen.- 6 Hyperreagibilität.- 6.1 Hyperreagibilität der Atemwege bei Asthma — Grundlage oder Folge?.- 6.1.1 Kriterien für die Diagnose: Asthma.- 6.1.2 Begriffsbestimmung der Hyperreagibilität der Atemwege.- 6.1.3 Pathomechanismus.- 6.1.3.1 Nervöse Regulation des Atemwegstonus.- 6.1.3.2 Autonome Imbalance.- 6.1.3.3 Atemwegsentzündung.- 6.1.3.4 Multifaktorielle Hypothese.- 6.1.4 Hyperreagibilität der Atemwege als Grundlage des Asthmas.- 6.1.5 Angeborene oder induzierte Hyperreagibilität der Atemwege?.- 6.1.6 Schlußfolgerungen.- 6.2 Die Überempfindlichkeit der Atemwege gegen pharmakologische, allergene, physikalische und osmotische Reize.- 6.2.1 Einleitung und Definition.- 6.2.2 Pharmakologische Reize.- 6.2.2.1 Histamin und m-Cholinozeptor-Agonisten (Cholinergika).- 6.2.2.2 ?-Adrenozeptor-Antagonisten (Betablocker).- 6.2.2.3 Allergene.- 6.2.2.4 Körperliche Belastung.- 6.2.2.4.1 Konzept des respiratorischen Wärmeaustausches.- 6.2.2.4.2 Konzept des respiratorischen Wassseraustausches.- 6.2.2.4.3 Variabilität der anstrengungsinduzierbaren Atemwegsobstruktion.- 6.2.2.5 Beziehung zwischen Anstrengungsasthma und Hyperreagibilität der Atemwege.- 6.2.2.6 Beziehung zwischen Überempfindlichkeit gegen SO2 und Histamin.- 6.2.2.7 Schlußfolgerungen.- 6.3 Zirkadiane Rhythmen bei Asthma.- 6.3.1 Nächtliche Dyspnoe.- 6.3.2 Bronchomotorischer Tonus.- 6.3.3 Biologische Rhythmen.- 6.3.3.1 Hormone.- 6.3.3.2 Mediatoren.- 6.3.3.2.1 Präformierte Mediatoren.- 6.3.3.2.2 Neugenerierte Mediatoren.- 6.3.3.3 Neurale Faktoren.- 6.3.3.4 Zelluläre Faktoren.- 6.3.3.5 Humorale Faktoren.- 6.3.3.6 Schlußfolgerungen.- 7 Ätiologie und Pathogenese.- 7.1 Allergene als Asthmaursache.- 7.2 Allergene: Struktur und individuelle Sensibilisierungsmuster.- 7.2.1 Reindarstellung und Charakterisierung von Allergenen.- 7.2.2 Beispiele bereits charakterisierter Allergene.- 7.2.3 Antigen-Substruktur und Angriffspunkte der Antikörper.- 7.2.4 Welche Substanzen sind im Einzelfall Antigen-wirksam 9.- 7.2.5 Darstellung der individuellen Sensibilisierungsmuster.- 7.2.5.1 Untersuchungsverfahren.- 7.2.5.2 Ergebnisse.- 7.2.6 Schlußfolgerungen.- 7.3 Asthma durch Nahrungsmittel und Zusatzstoffe.- 7.3.1 Immunologische und nicht-immunologische Reaktionen.- 7.3.2 Nahrungsmittelallergie, klinische Formen.- 7.3.3 Häufigkeit.- 7.3.4 Nahrungsmittel als Antigene.- 7.3.5 Nicht-allergene Hilfsstoffe in Lebensmitteln und Medikamenten (Additiva).- 7.3.6 Genußmittel — Alkoholika — als Asthma-Auslöser.- 7.3.7 Diagnostik.- 7.3.7.1 Nahrungsmittel-Allergien.- 7.3.7.2 Nahrungsmittel-Intoleranzen.- 7.3.7.3 Provokationstests.- 7.3.8 Schlußfolgerungen.- 7.4 Asthma durch Medikamente.- 7.4.1 Nicht-steroidale Antiphlogistika.- 7.4.2 Farb- und Konservierungsstoffe.- 7.4.3 ?-Adrenozeptor-Antagonisten.- 7.4.4 Weitere Medikamente.- 7.5 Asthma und Infektion.- 7.6 Luftschadstoffe als Auslöser oder Ursache von Hyperreagibilität und Asthma?.- 7.6.1 Relevante Luftschadstoffe.- 7.6.1.1 Schwefeldioxid (SO2).- 7.6.1.2 Stickstoffdioxid (NO2).- 7.6.1.3 Ozon (O3).- 7.6.2 Epidemiologische Untersuchungen.- 7.6.3 Expositionstests unter kontrollierten Bedingungen.- 7.6.4 Grundlagenforschung zur Pathogenese der Hyperreagibilität.- 7.6.4.1 Entzündung der Atemwegsmukosa.- 7.6.4.2 Hyperpermeabilität der Schleimhautbarriere.- 7.6.4.3 Reflexbronchokonstriktion.- 7.6.4.4 Interaktionen zwischen Wirkungen der Luftschadstoffe und Viren (Bakterien).- 7.6.5 Schlußfolgerungen.- 7.7 Auslösung und Unterhaltung des Asthmas durch psychologische Faktoren.- 7.7.1 Definition.- 7.7.2 Auslösung des Asthmas.- 7.7.2.1 Persönlichkeit des Kranken.- 7.7.2.2 Konditionierung und Suggestion.- 7.7.2.3 Psychophysiologie.- 7.7.2.4 Auslösung durch psychische Faktoren.- 7.7.3 Aufrechterhaltung der Symptomatik.- 7.7.3.1 Die Asthma-Symptom-Liste.- 7.7.3.2 Psychologische Aufrechterhaltung.- 7.7.3.3 Interozeption.- 7.7.4 Neue therapeutische Ansätze.- 7.7.4.1 Biofeedback des oszillatorischen Atemwiderstandes.- 7.7.4.2 Psychosomatisches Behandlungskonzept.- 7.8 Zusammenfassung und Übersicht: Ätiologie des Asthmas.- 8 Diagnostik.- 8.1 Allergiediagnostik: in-vivo- und in-vitro-verfahren.- 8.1.1 Indikationen zur Allergiediagnostik bei Asthma.- 8.1.2 Diagnostisches Vorgehen.- 8.1.2.1 Allergieanamnese.- 8.1.2.2 Karenz, Expositions- und Reexpositionstests.- 8.1.2.3 Hauttestung.- 8.1.2.4 In-vitro-Diagnostik.- 8.1.2.4.1 Eosinophile Granulozyten.- 8.1.2.4.2 Bestimmung des Gesamt-IgE und ähnliche Screeningverfahren.- 8.1.2.4.3 Allergenspezifisches Immunglobulin E.- 8.1.2.4.4 Andere immunologische Verfahren.- 8.1.2.5 Provokationstests mit Allergenen.- 8.1.2.5.1 Intranasaler Provokationstest, Konjunktivaltest.- 8.1.2.5.2 Inhalative Provokationstests der unteren Atemwege.- 8.1.3 Schlußfolgerungen.- 8.2 In-vitro-Diagnostik: Methoden der Allergenanalyse.- 8.2.1 Ziele der Allergenanalyse.- 8.2.2 Traditionelle Meßeinheiten für Allergenextrakte.- 8.2.2.1 NOON-Unit.- 8.2.2.2 Gewicht-pro-Volumen-Einheit (W/V = weight/volume).- 8.2.2.3 Protein-Stickstoff-Einheit (PNU).- 8.2.2.4 Klassische und modifizierte Proteinbestimmung nach Lowry.- 8.2.2.5 Kohlenhydratbestimmung (hier: Hexosenbestimmung = Anthronbestimmung).- 8.2.3 Biologische und immunbiochemische Methoden der Allergenanalyse.- 8.2.3.1 Molekulargewichtsbestimmung über die Ausschlußchromatographie, z. B. Hochleistungs-Flüssigkeits-Chromatographie (HPLC).- 8.2.3.2 Hochleistungs-Dünnschicht-Chromatographie (HPTLC).- 8.2.3.3 Isoelektrische Fokussierung (IEF).- 8.2.3.4 Natriumlaurylsulfat-Polyacrylamid-Gel-Elektro-phorese (SDS-PAGE).- 8.2.3.5 Zweidimensionale (Radio-) Immunelektrophorese = Crossed (Radio) Immunelectrophoresis / CIE (CRIE).- 8.2.3.6 Aufstellung eines Allergogramms über die Allergoprints einzelner Patienten.- 8.2.3.7 Nitrozellulose-Immunoprint (IP).- 8.2.3.8 Elektro-Immundiffusion, z. B. Rocket Immunelectrophoresis (RIE).- 8.2.3.9 Histaminfreisetzung aus basophilen Leukozyten (fluorimetrische Messung).- 8.2.3.10 Radioallergosorbent-Test (RAST).- 8.2.3.11 RAST-Hemmtest.- 8.2.3.12 Quantitativer Hauttest.- 8.2.3.13 Parallel Line Assay.- 8.2.3.14 Produktion von monoklonalen Antikörpern.- 8.2.3.15 Affinitätschromatographie.- 8.3 Funktionsdiagnostik bei Asthma.- 8.3.1 Grundlagen der Funktionsdiagnostik.- 8.3.2 Methoden, Geräte, Parameter, Interpretation.- 8.3.2.1 Peak Flow-Meter.- 8.3.2.2 Spirometrie.- 8.3.2.3 Pneumotachographie.- 8.3.2.4 Atemwiderstandsmessung; Unterbrechertechnik.- 8.3.2.5 Atemwiderstandsmessung; Oszilloresistometrie.- 8.3.2.6 Bestimmung der funktionellen Residualkapazität (FRC), Heliummethode.- 8.3.2.7 Ganzkörperplethysmographie.- 8.3.2.8 Blutgasanalyse.- 8.3.3 Die Lungenfunktionsdiagnostik der unspezifischen und spezifischen inhalativen Provokationstests.- 8.3.4 Abgestufte Funktionsdiagnostik des Asthmas.- 8.3.5 Funktionsdiagnostik zur Therapie-Indikation und Therapie-Kontrolle.- 8.3.6 Funktionelle Differentialdiagnostik.- 8.3.7 Schlußfolgerungen.- 8.4 Funktionsanalytische Differentialdiagnostik bei Asthma.- 8.4.1 Differentialdiagnostische Erwägungen.- 8.4.2 Restriktive und obstruktive Ventilationsstörung.- 8.4.3 Obstruktive Ventilationsstörungen.- 8.4.3.1 Lokalisation der Obstruktion.- 8.4.3.2 Differentialdiagnose Asthma — obstructive Bronchitis — Emphysem.- 8.4.3.2.1 Emphysem.- 8.4.3.2.2 Asthma und chronische obstruktive Bronchitis.- 8.4.4 Schlußfolgerungen.- 8.5 Unspezifische und spezifische Provokationstests der Atemwege.- 8.5.1 Übersicht.- 8.5.2 Unspezifische Provokationstests.- 8.5.2.1 Inhalative und nicht-inhalative Testverfahren — Übersicht.- 8.5.2.1.1 Inhalative Provokationstests.- 8.5.2.1.2 Belastungstests.- 8.5.2.1.3 Kaltluftprovokation.- 8.5.2.2 Probleme der Aerosolanwendung bei Provokationstests.- 8.5.2.2.1 Aerosole.- 8.5.2.2.2 Vernebler.- 8.5.2.2.3 Aerosoldosierung.- 8.5.2.2.4 Atemmanöver.- 8.5.2.3 Reaktionsbeurteilung.- 8.5.2.3.1 Pathophysiologische Veränderungen.- 8.5.2.3.2 Lungenfunktionsparameter.- 8.5.2.3.3 Erfassung anderer Funktionsstörungen.- 8.5.2.3.4 Bewertungskriterien der Provokationstests.- 8.5.2.3.5 Darstellung der Befunde.- 8.5.2.4 Aussagekraft unspezifischer Provokationstests.- 8.5.3 Allergen-Provokationstests (Spezifische Provokationstests).- 8.5.3.1 Methodik.- 8.5.3.1.1 Allergene.- 8.5.3.1.2 Aerosolapplikation.- 8.5.3.2 Atemwegsreaktion auf Allergen-Provokation.- 8.5.3.3 Bewertung.- 8.5.3.4 Indikation.- 8.5.3.5 Beziehung zwischen unspezifischer Hyperreagibilität der Atemwege, Ausfall von Allergen-Provokationstests und allergenspezifischem IgE.- 8.5.3.6 Voraussetzungen seitens des Patienten.- 8.5.4 Schlußfolgerungen.- 8.6 Bronchoskopie und bronchoalveoläre Lavage bei Asthma.- 8.6.1 Indikationen.- 8.6.2 Methodik.- 8.6.2.1 Bronchoskopie und BAL.- 8.6.2.2 Aufarbeitung des BAL-Materials.- 8.6.3 Nebenwirkungen.- 8.6.4 Endoskopische und bioptische Befunde bei Asthma.- 8.6.5 Ergebnisse der BAL bei Asthma.- 8.6.5.1 Zytologische Befunde.- 8.6.5.2 Zellfunktion.- 8.6.5.3 Mediatoren.- 8.6.6 Schlußfolgerungen.- 9 Therapie.- 9.1 Hyposensibilisierung mit herkömmlichen und modifizierten Allergen-Extrakten.- 9.1.1 Definitionen und Historie.- 9.1.2 Wirksamkeit bei Asthma.- 9.1.3 Wirkungsmechanismen.- 9.1.4 Allergen-Extrakte.- 9.1.4.1 Wäßrige Extrakte.- 9.1.4.2 Depot-Extrakte.- 9.1.4.3 Modifizierte Allergene (Allergoide).- 9.1.5 Praktische Durchführung der Hyposensibilisierung.- 9.1.5.1 Auswahl der Allergene.- 9.1.5.2 Dosierung und Dauer der Therapie.- 9.1.6 Schlußfolgerungen: Stellenwert der Hyposensibilisierung im Rahmen der antiasthmatischen Dauertherapie.- 9.2 Medikamentöse Therapie.- 9.2.1 Grundzüge der Therapie.- 9.2.2 Therapieziele.- 9.2.3 Bronchodilatierende und prophylaktische (antibronchokonstriktorische, antiinflammatorische) Eigenschaften der Antiasthmatika.- 9.2.4 Wirkungen und Nebenwirkungen der Antiasthmatika.- 9.2.4.1 ?2-Adrenozeptor-Agonisten (= ?2-Sympathikomimetika).- 9.2.4.1.1 Pharmakodynamische und klinische Wirkungen.- 9.2.4.1.2 Wirkungsmechanismus auf zellulärer und molekularer Ebene.- 9.2.4.1.3 Pharmakokinetik.- 9.2.4.1.4 Nebenwirkungen.- 9.2.4.1.5 Klinische Aspekte.- 9.2.4.2 Theophyllin.- 9.2.4.2.1 Pharmakodynamische und klinische Wirkungen.- 9.2.4.2.2 Wirkungsmechanismus auf zellulärer und molekularer Ebene.- 9.2.4.2.3 Pharmakokinetik.- 9.2.4.2.4 Nebenwirkungen.- 9.2.4.2.5 Klinische Aspekte.- 9.2.4.3 m-Cholinozeptor-Antagonisten (Anticholinergika, Muskarinantagonisten).- 9.2.4.3.1 Pharmakodynamische und klinische Wirkungen.- 9.2.4.3.2 Wirkungsmechanismus auf zellulärer und molekularer Ebene.- 9.2.4.3.3 Nebenwirkungen.- 9.2.4.3.4 Klinische Aspekte.- 9.2.4.4 Weitere Substanzen mit potentieller bronchodilatierender Wirkung.- 9.2.4.4.1 Calcium.- 9.2.4.4.2 Calciumantagonisten.- 9.2.4.4.3 ?-Adrenozeptor-Antagonisten.- 9.2.4.4.4 Neuropeptide.- 9.2.4.4.5 Coffein.- 9.2.4.5 Mediatorantagonisten.- 9.2.4.5.1 Histamin-Rezeptor-Antagonisten.- 9.2.4.5.2 Weitere Mediatorantagonisten.- 9.2.4.6 Ketotifen.- 9.2.4.6.1 Pharmakodynamische und klinische Wirkungen.- 9.2.4.6.2 Wirkungsmechanismus.- 9.2.4.6.3 Pharmakokinetik.- 9.2.4.6.4 Nebenwirkungen.- 9.2.4.6.5 Klinische Aspekte.- 9.2.4.7 Cromoglicinsäure, Dinatriumsalz (Dinatrium cromoglicicum, DNCG).- 9.2.4.7.1 Klinische und pharmakologische Wirkungen.- 9.2.4.7.2 Wirkungsmechanismus.- 9.2.4.7.3 Pharmakokinetik.- 9.2.4.7.4 Nebenwirkungen.- 9.2.4.7.5 Klinische Aspekte.- 9.2.4.8 Weitere nicht-steroidale antiinflammatorische Substanzen (Prophylaktika).- 9.2.4.9 Nedocromil-Natrium.- 9.2.4.10 Glukokortikosteroide.- 9.2.4.10.1 Klinische und pharmakologische Wirkungen.- 9.2.4.10.2 Zelluläre und molekulare Wirkungsmechanismen.- 9.2.4.10.3 Nebenwirkungen.- 9.2.4.10.4 Klinische Aspekte.- 9.2.4.11 Weitere medikamentöse Maßnahmen.- 9.2.4.11.1 Expektorantien.- 9.2.4.11.2 Antibiotika.- 9.2.5 Kontraindizierte Medikamente.- 9.2.6 Schlußfolgerungen: medikamentöse Stufentherapie (Dauertherapie, schwerer Asthmaanfall).- 9.3 Besonderheiten der medikamentösen Therapie im Kindes- und Jugendlichenalter.- 9.3.1 Ziel der Therapie.- 9.3.2 ?2-Adrenozeptor-Agonisten (?2-Sympathikomimetika).- 9.3.2.1 Akuttherapie.- 9.3.2.2 Dauertherapie.- 9.3.2.3 Nebenwirkungen.- 9.3.3 m-Cholinozeptor-Antagonisten (Anticholinergika).- 9.3.3.1 Akut- und Dauertherapie.- 9.3.3.2 Nebenwirkungen.- 9.3.4 Theophyllin.- 9.3.4.1 Akuttherapie.- 9.3.4.2 Dauertherapie.- 9.3.4.3 Nebenwirkungen.- 9.3.5 Cromoglicinsäure, Dinatriumsalz (DNCG).- 9.3.6 Kortikosteroide.- 9.3.6.1 Akut- und Dauertherapie.- 9.3.6.2 Nebenwirkungen.- 9.3.7 Ketotifen.- 9.3.8 Medikamentöse Stufentherapie im Kindesalter.- 9.3.9 Therapie bei Asthma durch Nahrungsmittelallergie.- 9.3.10 Schlußfolgerungen.- 9.4 Indikationen und Formen der inhalativen Therapie.- 9.4.1 Grundsätzliches zur Inhalationstherapie.- 9.4.2 Einfluß verschiedener Mechanismen auf die Partikel-Deposition.- 9.4.3 Geräte und ihre Handhabung.- 9.4.3.1 Vorrichtungen zur Inhalation.- 9.4.3.2 Wartung der Geräte und Hygienemaßnahmen.- 9.4.4 Medikamente.- 9.4.4.1 ?2-Adrenozeptor-Agonisten (?2-Sympathikomimetika).- 9.4.4.2 m-Cholinozeptor-Antagonisten (Anticholinergika).- 9.4.4.3 Cromoglicinsäure, Dinatriumsalz (DNCG).- 9.4.4.4 Nedocromil-Natrium.- 9.4.4.5 Kortikosteroide.- 9.4.4.6 Adrenalin.- 9.4.4.7 Expektoranzien.- 9.4.4.8 Weitere Gesichtspunkte.- 9.4.4.9 Schlußfolgerungen.- 9.5 Sinnvolle Kombinationstherapie mit Monosubstanzen und Kombinationspräparaten.- 9.5.1 Indikationen zur Kombinationstherapie mit Monosubstanzen.- 9.5.2 Klinisch nachgewiesene synergistische Wirkungen von Antiasthmatika.- 9.5.3 Fixe Kombinationen.- 9.5.4 Schlußfolgerungen.- 9.6 Patientenschulung — wesentlicher Bestandteil einer effektiven Asthmatherapie?.- 9.6.1 Unveränderte Asthma-Letalität.- 9.6.2 Patientenschulung.- 9.6.3 Asthma-Behandlungs- und -Schulungsprogramm.- 9.6.3.1 Ziele der Behandlung und Schulung.- 9.6.3.2 Erste Ergebnisse.- 9.6.4 Schlußfolgerungen.- 9.7 Steuerung und Überwachung der Therapie bei Asthma.- 9.7.1 Therapiesteuerung — eine Aufgabe für Arzt und Patient.- 9.7.2 Ziel der Therapie.- 9.7.3 Steuerung der Therapie durch den Arzt.- 9.7.4 Steuerung der Therapie durch den Patienten.- 9.7.5 Merkworte für den Arzt.- 9.7.6 Merkworte für den Patienten.- 9.7.7 Schlußfolgerungen.- 9.8 Zusammenfassung und Übersicht: Asthmatherapie.

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Book SynopsisDieses Buch passt in die Kitteltasche jedes Kinder- und Jugendarztes! Bei der Erstversorgung erkrankter Kinder gilt die Devise: Richtig einschätzen, schnell entscheiden, sicher handeln – auf Station, in der Ambulanz und in der Notaufnahme, Tag und Nacht. Das Ambulanzmanual Pädiatrie hat sich als nützlicher Begleiter bewährt, um das eigene Wissen schnell aufzurufen und in jeder Situation adäquat reagieren zu können.Nach A-Z praktisch gegliedert, sind alle gängigen Krankheitsbilder, typischen Leitsymptome und weitere wichtige Themen der Kinder- und Jugendmedizin sofort auffindbar und in komprimierter Form nachzulesen. Fallstricke und mögliche Komplikationen springen unmittelbar ins Auge.Das Ambulanzmanual Pädiatrie wurde von Münchner Klinikärzten aus den Alltagserfahrungen heraus entwickelt und erfolgreich eingesetzt. Seine Spezialität: es enthält Symptome und Notfälle, wie sie in der Ambulanz wirklich vorkommen, von Acne vulgaris über Erbrechen bis zu Meningitis.Für die 5. Auflage wurde das gesamte Buch einschließlich des Medikamententeils auf den neuesten Stand gebracht. Speziell wurde die Therapie von Infektionen überarbeitet, zudem wurde die Dosisanpassung bei Niereninsuffizienz eingearbeitet. Trade Review“... ein übersichtlich angeordnetes, alphabetisch sortiertes Grundlagenwissen und eine kompakte Sammlung von praktischen Anleitungen für die fundierte Erstversorgung akut und chronisch kranker Kinder ...” (Dr. Ulrich Mutschler, in: Pädiatrie, Jg. 32, Heft 2, 2020)Table of ContentsVon Acne vulgaris bis Vergiftung.- Plus Medikamentenverzeichnis.

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Book Synopsis

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Book Synopsis

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Book SynopsisPart 1 Concept of Asthma COPD overlap.- 1 Concept of Asthma COPD overlap - Japanese guideline and global trends. How was the concept of Asthma COPD overlap developed and moving forward? .- 2 Concept of treatable traits and ACO (2): Can treatable traits approach be applied into practice? .- Part 2 Epidemiology and Prognosis.- 3 Epidemiology of ACO from global data: Does the prevalence of ACO vary among global analyses? .- 4 Epidemiology of ACO defined by the JRS guidelines. What is the prevalence of ACO in Japan? .- 5 Prognosis and characteristics of ACO: What are the specific characteristics of ACO?- 6 Prognosis of COPD with asthma-like features and ACO: Is the prognosis of COPD and ACO different? .- 7 Causes of death in patients with asthma-chronic obstructive pulmonary disease overlap: Is there any difference compared to asthma?.- Part 3 Pathophysiology of ACO.- 8 Inflammatory phenotypes and potential bio-markers of ACO. What is the specific feature of ACO? .- 9 Role of Nitrosative stress: What is the potential clinical implication?.- 10 Radiographic features of ACO. How the feature is applied into practice?.- 11 Pulmonary Function of ACO: What is the role of the forced oscillation technique?.- 12 Underlying mechanism suggested by the ACO model. What is the lesson learned from the model?.- Part 4 Diagnosis of ACO.- 13 Comparison of diagnostic criteria of ACO: What is the point of difference?.- 14 Role of FeNO - How can FeNO be positioned in practice?.- 15 Role of IgE and Eosinophils: The use of type 2 biomarkers in practice.- 16 Rhinosinusitis in ACO: What is the implication of nasal comorbidity?.- Part 5 Treatment.- 17 Current evidence of treatment for asthma-COPD overlap (ACO): Is there emerging evidence of optimal therapy? .- 18 Potential treatment options for ACO, including biologics: Are there any roles of biologics?.

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