Medical specialties, branches of medicine Books
John Wiley & Sons Inc BenefitRisk Appraisal of Medicines A Systematic
Book SynopsisEstablishes the criteria required to assess benefit-risk in general and reviews the current practice of benefit-risk assessment by drug regulatory authorities and the pharmaceutical industry. Outlines how the new MCDA model was developed and evaluated, and discusses the implications of its implementation into the practice of drug evaluation.Table of ContentsForeword. Preface. 1 Concept and Scope of Benefit–Risk Evaluation of Medicines. 1.1 Historical backgroun. 1.2 The regulatory systems for assessing medicines. 1.3 Benefit–risk assessment: definitions. 1.4 Views and perceptions of benefits and risks of medicines. 1.5 Stages and concepts in benefit–risk assessment. 1.6 Benefit–risk assessment: the current regulatory environment. 1.7 Benefit–risk assessment in other disciplines. 1.8 Specific methods and models for benefit–risk assessment. 1.9 Discussions with stakeholders on the concepts and models for benefit–risk evaluation. 2 Criteria for a Benefit–Risk Model: a Conceptual Framework. 2.1 Introduction. 2.2 Regulatory guidelines on benefit and risk criteria. 2.3 Identification, definition and rationale of relevant benefit and risk criteria. 2.4 Verification of the list of benefit and risk criteria by means of a survey. 3 Review of the Current Benefit–Risk Assessment Models. 3.1 Background. 3.2 Evaluation of the existing benefit–risk assessment models. 3.3 Review of models in single clinical trials and for specific medicines. 3.4 Conclusion. 3.5 Newer models. 4 Defining a Systematic Approach to Decision Making. 4.1 Introduction. 4.2 Objectives and features of the ideal model for benefit–risk assessment. 4.3 The use of decision-analysis techniques for the development of the new model. 5 Development and Application of a Benefit–Risk Assessment Model Based on Multi-Criteria Decision Analysis. 5.1 Introduction. 5.2 Conceptualization of the new model. 5.3 Reasons for using decision analysis techniques in the new model. 5.4 The use of MCDA in the new model. 5.5 Development of the new model. 5.6 Applicability of the new model. 5.7 Summary. 5.8 Review of the MCDA model. 6 A Future Framework for Benefit–Risk Appraisal of Medicines. 6.1 Background. 6.2 Development of a benefit–risk framework for regulatory review of new medicines. 6.3 Prerequisites of a benefit–risk framework for the registration of a new medicine. 6.4 Current status of benefit–risk assessment among companies and agencies. 6.5 Constructing a benefit–risk framework. 6.6 Conclusion. Appendices. Appendix 1 Summary Reports of the CMR International Institute for Regulatory Science March 2004 and June 2005 Workshops on Benefit–Risk. Appendix 2 Office of Health Economics Briefing: Challenges and Opportunities for Improving Benefit–risk Assessment of Pharmaceuticals from an Economic Perspective – James Cross and Louis Garrison (August 2008). Appendix 3 Reflection Paper on Benefit–risk Assessment Methods in the Context of the Evaluation of Marketing Authorisation Applications of Medicinal Products for Human Use – Committee for Medicinal Products for Human Use (March 2008). Appendix 4 Commentaries on ‘A Quantitative Approach to Benefit–risk Assessment of Medicines’ Pharmacoepidemiology and Drug Safety, 2007, 16. Appendix 5 Forum on Benefit: Risk Decision Analysis – Summary of Discussions and Recommendations – MHRA (September 2008). References. Index.
£94.95
John Wiley and Sons Ltd Hendees Radiation Therapy Physics
Book SynopsisThe publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee's tradition, Hendee's Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-anTrade Review"The book is well structured and gives an excellent overview on all practical aspects of modern radiotherapy and the physics involved. The many examples and problems allow for immediate check of the understanding of the text and make it fun to read. The new editors certainly did a very good job in carrying on the tradition of the original book" Physica Medica, Feb 2017. Full review available here "The newly published fourth edition of Hendee’s Radiation Therapy Physics (Authors: Todd Pawlicki, Daniel J. Scanderbeg, George Starkschall) provides an updated overview, analysis and practical guidance of the various aspects of the radiation therapy physics. Published ten years after the publication of the third edition, this book reviews all newly introduced modalities and approaches inRadiation therapy - intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), digital imaging, CT simulation, proton therapy, radiation therapy informatics. An important part of the book is the focus on the professional approaches in radiation protection, patient safety, quality assurance, quality improvement and even training for residents. The book is written by experts in the field – all three authors are well known professionals working in the field of Radiation Physics and Radiation Medicine. Throughout this book the reader finds scientific, educational and practical information from the very basics of radiation physics to the latest achievements in the field of Radiation Therapy. Each chapter is well structured, giving a good balance between the theoretical and practical aspects. The appendix is dedicated to solving practical problems and provides professional advice, as well as self-tests......This book is both an excellent reference which will be useful in all medical physics departments and at the same time a perfect guidance material for professionals in related specialties. It continues very well the line set by Prof. William Hendee (past IOMP ExCom member). The Content and Structure of the book are excellent. These are really necessary for a book with such coverage and volume. Thefourth edition of Hendee’s Radiation Therapy Physics is yet another fundamental book that will be very useful reference for various specialists for many yearsahead" - Medical Physics World 2016Table of ContentsPreface to the Fourth Edition, vi Preface to the Third Edition, vii Preface to the Second Edition, viii Preface to the First Edition, ix 1 Atomic Structure and Radioactive Decay, 1 2 Interactions of X Rays and Gamma Rays, 16 3 Interactions of Particulate Radiation with Matter, 29 4 Machines for Producing Radiation, 35 5 Measurement of Ionizing Radiation, 57 6 Calibration of Megavoltage Beams of X Rays and Electrons, 77 7 Central-axis Point Dose Calculations, 96 8 External Beam Dose Calculations, 110 9 External Beam Treatment Planning and Delivery, 123 10 The Basics of Medical Imaging, 146 11 Diagnostic Imaging and Applications to Radiation Therapy, 154 12 Tumor Targeting: Image-guided and Adaptive Radiation Therapy, 170 13 Computer Systems, 182 14 Radiation Oncology Informatics, 197 15 Physics of Proton Radiation Therapy, 204 16 Sources for Implant Therapy and Dose Calculation, 215 17 Brachytherapy Treatment Planning, 231 18 Radiation Protection, 248 19 Quality Assurance, 267 20 Patient Safety and Quality Improvement, 294 Appendix: Answers to Selected Problems, 310 Index, 317
£132.00
John Wiley & Sons Inc Analytical Methods for Therapeutic Drug
Book SynopsisThis book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summariesthan sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.Trade Review"This book is valuable for pharmacologists, toxicologists, and health professionals working in academic, industrial, and regulatory agencies who are involved in therapeutic drug monitoring. . . This is a comprehensive sourcebook that details 964 different analytical methods for 511 different drugs." (Doody's, 9 September 2011) "This is an important reference for students and professionals involved with barley research, production, trade, and utilization. Editor Ullrich is an agronomist affiliated with Washington State U." (Booknews, 1 April 2011) Table of ContentsPreface. MONOGRAPHS. Abacavir. Abecarnil. Acamprosate Calcium. Acebutolol Hydrochloride. Aceclofenac. Acemetacin. Acenocoumarol. Acetaminophen. Acetazolamide. Aconitine. Acrivastine. Acyclovir. Albendazole. Albuterol. Alcuronium Chloride. Alfentanil Hydrochloride. Alfuzosin Hydrochloride. Allobarbital. Allopurinol. Alprazolam. Alprenolol. Ambroxol Hydrochloride. Amikacin. Amiloride Hydrochloride. Amiodarone Hydrochloride. Amisulpride. Amitriptyline Hydrochloride. Amlodipine Besylate. Amobarbital. Amoxapine. Amoxicillin. Amphetamine. Amphotericin B. Ampicillin. Amprenavir. Amsacrine. Apomorphine Hydrochloride. Aripiprazole. Arotinolol Hydrochloride. Artemisinin. Artesunate. Aspirin. Atazanavir Sulfate. Atenolol. Azathioprine. Azithromycin. Baclofen. Barbital. Benactyzine Hydrochloride. Bendroflumethiazide. Benzthiazide. Benzylpenicillin Potassium. Betaxolol Hydrochloride. Biapenem. Bisoprolol Fumarate. Bromazepam. Bromisoval. Bromperidol. Brompheniramine Maleate. Buflomedil Hydrochloride. Bumetanide. Buparvaquone. Bupivacaine Hydrochloride. Buprenorphine. Bupropion Hydrochloride. Buspirone Hydrochloride. Busulfan. Caffeine. Candesartan Cilexetil. Canrenone. Capecitabine. Capreomycin Sulfate. Carbamazepine. Carbidopa. Carbinoxamine Maleate. Carboplatin. Carbromal. Carteolol Hydrochloride. Carvedilol. Caspofungin Acetate. Cathine. Cefaclor. Cefadroxil. Cefalexin. Cefazolin Sodium. Cefdinir. Cefditoren Pivoxil. Cefepime Hydrochloride. Cefixime. Cefotaxime Sodium. Cefozopran Hydrochloride. Cefpiramide. Cefpirome Sulfate. Cefpodoxime Proxetil. Cefprozil. Ceftazidime. Ceftibuten. Ceftiofur Hydrochloride. Ceftizoxime Sodium. Ceftriaxone Sodium. Cefuroxime. Celecoxib. Celiprolol Hydrochloride. Cephalexin Hydrochloride. Cetirizine Hydrochloride. Chloramphenicol. Chlordiazepoxide. Chlorhexidine Acetate. Chlorothiazide. Chlorphenamine Maleate. Chlorpromazine. Chlorpropamide. Chlorthalidone. Cilnidipine. Cimetidine. Ciprofloxacin. Cisapride. Cisplatin. Citalopram Hydrobromide. Clarithromycin. Clavulanate Potassium. Clemastine Fumarate. Clenbuterol Hydrochloride. Clinafloxacin Hydrochloride. Clobazam. Clofazimine. Clomipramine Hydrochloride. Clonazepam. Clonidine. Clopamide. Cloperastine. Clotiapine. Cloxacillin. Clozapine. Cocaine. Codeine. Cotinine. Cyclopenthiazide. Cyclophosphamide. Cyclosporine. Cyproheptadine Hydrochloride. Cytarabine. Dabigatran Etexilate. Dapsone. Daptomycin. Darunavir. Debrisoquine Sulfate. Decitabine. Delavirdine Mesylate. Derxazoxane. Desipramine Hydrochloride. Desloratadine. Dexamethasone. Dexfenfluramine Hydrochloride. Dextromethorphan Hydrobromide. Dextromoramide Tartrate. Diamorphine Hydrochloride. Diazepam. Dibenzepin Hydrochloride. Diclofenac Sodium. Diclofenamide. Dicloxacillin Sodium. Didanosine. Digoxin. Diltiazem Hydrochloride. Dimethylformamide. Dimethylsulfoxide. Diphemanil Metilsulfate. Diphenhydramine Hydrochloride. Diphenylpyraline Hydrochloride. Diprophylline. Dipyridamole. Dipyrone. Docetaxel. Donepezil Hydrochloride. Dopamine Hydrochloride. Doripenem. Dosulepin Hydrochloride. Doxapram Hydrochloride. Doxazosin Mesylate. Doxepin Hydrochloride. Doxifluridine. Doxofylline. Doxorubicin Hydrochloride. Doxycycline. Doxylamine Succinate. Droloxifene. Droperidol. Drospirenone. Ecabet Sodium. Efavirenz. Emedastine Difumarate. Emtricitabine. Enalapril Maleate. Enoxacin. Enoxolone (Glycyrrhetic Acid). Ephedrine Hydrochloride. Epinephrine. Eprosartan Mesylate. Erlotinib Hydrochloride. Ertapenem Sodium. Escitalopram Oxalate. Esmolol Hydrochloride. Estazolam. Ethacrynic Acid. Ethambutol Hydrochloride. Ethionamide. Ethosuximide. Ethotoin. Etodolac. Etoposide. Everolimus. Famotidine. Faropenem Sodium. Felbamate. Felodipine. Fenoterol. Fenretinide. Fentanyl Citrate. Fexofenadine Hydrochloride. Flavopiridol. Flecainide Acetate. Fleroxacin. Floxacillin. Fluconazole. Flucytosine. Flunarizine Hydrochloride. Flunitrazepam. Fluorouracil. Fluoxetine Hydrochloride. Flupentixol Decanoate. Fluphenazine Hydrochloride. Flurbiprofen Sodium. Fluvoxamine Maleate. Formic Acid. Furosemide. Gabapentin. Ganciclovir. Garenoxacin Mesylate. Gatifloxacin. Gemcitabine Hydrochloride. Gemfibrozil. Glibenclamide. Glimepiride. Gluconolactone. Griseofulvin. Haloperidol. Heptabarbital. Homochlorcyclizine Hydrochloride. Hydrochlorothiazide. Hydrocortisone. Ibafloxacin. Ibudilast. Ibuprofen. Ifenprodil Tartrate. Ifosfamide. Imatinib Mesylate. Imidafenacin. Imipenem. Imipramine. Indapamide. Indinavir Sulfate. Indomethacin. Iomeprol. Iprindole Hydrochloride. Irbesartan. Isepamicin. Isoniazid. Itraconazole. Kanamycin A. Ketamine Hydrochloride. Ketanserin. Ketobemidone Hydrochloride. Ketoconazole. Ketoprofen. Ketorolac Tromethamine. Ketotifen Fumarate. Labetalol Hydrochloride. Lacidipine. Lamivudine. Lamotrigine. Lansoprazole. Lapatinib Ditosylate. Lercanidipine Hydrochloride. Levetiracetam. Levocetirizine. Levodopa. Levofloxacin. Levomepromazine Hydrochloride. Levonorgestrel. Lidocaine. Lomefloxacin Hydrochloride. Lopinavir. Loratadine. Lorazepam. Losartan Potassium. Loxapine. Lysergide. Manidipine Hydrochloride. Maprotiline. Mefruside. Melitracen Hydrochloride. Meloxicam. Melperone Hydrochloride. Mepindolol Sulfate. Mercaptopurine. Meropenem. Mesalazine. Mesuximide. Metformin Hydrochoride. Methadone Hydrochloride. Methamphetamine Hydrochloride. Methcathinone. Methotrexate. Methyclothiazide. 3,4-Methylenedioxyamphetamine. 3,4-Methylenedioxymethamphetamine. Methylephedrine Hydrochloride. Metoclopramide Hydrochloride. Metolazone. Metoprolol. Metronidazole. Mexiletine Hydrochloride. Mianserin Hydrochloride. Midazolam Hydrochloride. Milnacipran Hydrochloride. Minocycline Hydrochloride. Minoxidil. Mirtazapine. Mitotane. Moclobemide. Modafinil. Montelukast Sodium. Morphine. Moxifloxacin. Mycophenolate Mofetil. Nadolol. Nafcillin Sodium. Naftifine Hydrochloride. Naproxen Sodium. Nateglinide. Nelfinavir Mesylate. Nevirapine. Nicardipine Hydrochloride. Nifedipine. Nimesulide. Nimodipine. Nisoldipine. Nitrazepam. Nitrendipine. Nizatidine. Nordazepam. Norepinephrine Bitartrate. Norfloxacin. Nortriptyline Hydrochloride. Nystatin. Octopamine. Ofloxacin. Olanzapine. Olopatadine Hydrochloride. Omeprazole. Opipramol Hydrochloride. Orphenadrine Citrate. Oxacillin Sodium. Oxazepam. Oxcarbazepine. Oxolinic Acid. Oxprenolol Hydrochloride. Paclitaxel. Paroxetine. Pasiniazide. Pefloxacin Mesylate. Pemoline. Penciclovir. Pentazocine Hydrochloride. Pentisomide. Pentobarbital. Pentoxifylline. Perazine Dimalonate. Perifosine. Perphenazine. Pethidine Hydrochloride. Phenazone. Phencyclidine Hydrochloride. Phenethylamine. Pheneturide. Phenobarbital Sodium. Penicillin V. Phenprocoumon. Phenylethanolamine. Phenytoin. Pimozide. Pindolol. Pipamperone. Piperacillin Sodium. Pipethanate Ethobromide. Pirarubicin. Piroxicam. Posaconazole. Prednisolone. Pregabalin. Primidone. Probenecid. Procainamide Hydrochloride. Proguanil Hydrochloride. Promethazine Hydrochloride. Propofol. Propranolol Hydrochloride. Protionamide. Protriptyline Hydrochloride. Pseudoephedrine. Pyrazinamide. Pyrimethamine. Quetiapine Fumarate. Quinethazone. Quinine Sulfate. Raltegravir Potassium. Ranitidine Hydrochloride. Reboxetine Mesylate. Resveratrol. Ribavirin. Rifampin. Rifapentine. Riluzole. Risperidone. Ritonavir. Rizatriptan Benzoate. Rofecoxib. Rogletimide. Ropivacaine Hydrochloride. Salicylic Acid. Saquinavir. Secbutabarbital Sodium. Secobarbital Sodium. Serotonin. Sertraline Hydrochloride. Sildenafil Citrate. Sirolimus. Sodium Valproate. Sotalol Hydrochloride. Sparfloxacin. Spironolactone. Stavudine. Sufentanil Citrate. Sulfadiazine. Sulfadoxine. Sulfamerazine. Sulfamethizole. Sulfamethoxazole. Sulfaquanidine. Sulpiride. Sultopride Hydrochloride. Sumatriptan Succinate. Tacrine Hydrochloride. Tacrolimus. Tadalafil. Tamoxifen Citrate. Tegaserod Maleate. Telithromycin. Telmisartan. Temazepam. Teniposide. Tenofovir. Terazosin Hydrochloride. Terbutaline Sulfate. Tertatolol Hydrochloride. Testosterone. Tetracaine Hydrochloride. Theobromine. Theophylline. Thioguanine. Thioridazine. Thiotepa. Tiapride Hydrochloride. Timolol Maleate. Tipranavir. Tobramycin. Tolbutamide. Toloxatone. Topiramate. Toremifene Citrate. Torsemide. Tosufloxacin. Tramadol Hydrochloride. Triamterene. Triazolam. Trimethoprim. Trimipramine. Triprolidine Hydrochloride. Tryptophan. Tyramine Hydrochloride. Valacyclovir Hydrochloride. Valganciclovir Hydrochloride. Valproic Acid. Vancomycin Hydrochloride. Venlafaxine Hydrochloride. Verapamil Hydrochloride. Vigabatrin. Viloxazine Hydrochloride. Vincristine Sulfate. Vinorelbine Tartrate. Voriconazole. Vorinostat. Warfarin Sodium. Zalcitabine. Zidovudine. Zolmitriptan. Zonisamide. Zopiclone. Zotepine. Zuclopenthixol Hydrochloride. Index.
£150.05
John Wiley & Sons Inc Basics of Biomedical Ultrasound for Engineers
Book SynopsisBasics of Biomedical Ultrasound for Engineers is a structured textbook for university engineering courses in biomedical ultrasound and for researchers in the field. This book offers a tool for building a solid understanding of biomedical ultrasound, and leads the novice through the field in a step-by-step manner.Table of ContentsPreface. Acknowledgments. Introduction. Prelude and Basic Definitions. The Advantages of Using Ultrasound in Medicine. A General Statement on Safety. Some Common Applications of Ultrasound. What Is It that We Need to Know? References. 1 Waves—A General Description. 1.1 General Definitions of Waves—A Qualitative Description. 1.2 General Properties of Waves—A Qualitative Description. 1.3 Mechanical One-Dimensional Waves. 1.4 The Wave Function. 1.5 The Wave Equation. 1.6 Harmonic Waves. 1.7 Group Waves. 1.8 Wave Velocity. 1.9 Standing Waves (a Mathematical Description). 1.10 Spherical Waves. 1.11 Cylindrical Waves. 1.12 The Wave Equation in a Nonhomogeneous Medium. References. 2 Waves In A One-Dimensional Medium. 2.1 The Propagation Speed of Transverse Waves in a String. 2.2 Vibration Frequencies for a Bounded String. 2.3 Wave Reflection (Echo) in a One-Dimensional Medium. 2.4 Special Cases. 2.5 Wave Energy in Strings. 2.6 Propagation of Longitudinal Waves in an Isotropic Rod or String. 2.7 A Clinical Application of Longitudinal Waves in a String. References. 3 Ultraspmoc Waves in Fluids. 3.1 Waves in Fluids. 3.2 Compressibility. 3.3. Longitudinal Waves in Fluids. 3.4 The Wave Energy. 3.5 Intensity. 3.6 Radiation Pressure. 3.7 A Perfect Reflector. References. 4 Propogation of Acoustic Waves in Solid Materials. 4.1 Introduction to the Mechanics of Solids. 4.2 The Elastic Strain. 4.3 Stress. 4.4 Hooke’s Law and Elastic Coefficients. 4.5 The Wave Equation for an Elastic Solid Material. 4.6 Propagation of a Harmonic Planar Wave in a Solid Material. References. 5 Attenuation and Dispersion. 5.1 The Attenuation Phenomenon. 5.2 Explaining Attenuation with a Simple Model. 5.3 Attenuation Dependency on Frequency. 5.4 The Complex Wave Number. 5.5 Speed of Sound Dispersion. 5.6 The Nonlinear Parameter B/A. References. 6 Reflection and Transmission. 6.1 The Acoustic Impedance. 6.2 Snell’s Law. 6.3 Reflection and Transmission from Boundaries Separating Two Fluids (or Solids with No Shear Waves). 6.4 Reflection from a Free Surface in Solids (Mode Conversion). 6.5 Reflection and Transmission from a Liquid– Solid Boundary. References. 7 ACOUSTIC LENSES AND MIRRORS. 7.1 Optics. 7.2 Optics and Acoustics. 7.3 An Ellipsoidal Lens. 7.4 Spherical Lenses. 7.5 Zone Lenses. 7.6 Acoustic Mirrors (Focusing Reflectors). References. 8 Transducers and Acoustic Fields. 8.1 Piezoelectric Transducers. 8.2 The Acoustic Field. 8.3 The Field of a Point Source. 8.4 The Field of a Disc Source. 8.5 The Field of Various Transducers. 8.6 Phased-Array Transducers. 8.7 Annular Phased Arrays. References. 9 Ultrasonic Imaging Using the Pulse-Echo Technique. 9.1 Basic Definitions in Imaging. 9.2 The “A-Line”. 9.3 Scatter Model for Soft Tissues. 9.4 Time Gain Compensation. 9.5 Basic Pulse-Echo Imaging (B-Scan). 9.6 Advanced Methods for Pulse-Echo Imaging. References. 10 Special Imaging Techniques. 10.1 Acoustic Impedance Imaging—Impediography. 10.2 Elastography. 10.3 Tissue Speckle Tracking. 10.4 Through-Transmission Imaging. 10.5 Vibro-acoustic Imaging. 10.6 Time Reversal. 10.7 Ultrasonic Computed Tomography. 10.8 Contrast Materials. 10.9 Coded Excitations. References. 11 Doppler Imaging Techniques. 11.1 The Doppler Effect. 11.2 Velocity Estimation. 11.3 Frequency Shift Estimation. 11.4 Duplex Imaging (Combined B-Scan and Color Flow Mapping). References. 12 Safety and Therapuetic Applications. 12.1 Effects Induced by Ultrasound and Safety. 12.2 Ultrasonic Physiotherapy. 12.3 Lithotripsy. 12.4 Hyperthermia HIFU and Ablation. 12.5 Drug Delivery. 12.6 Gene Therapy. 12.7 Cosmetic Applications. References. Appenidx A: Typical Acoustic Properties of Tissues. Appendix B: Exemplary Problems. Appendix C: Answers to Exemplary Problems. Index.
£110.15
John Wiley & Sons Inc Urogenital Imaging
Book Synopsis Organised according to presenting signs, with discussion of appropriate investigations Outlines strengths and weaknesses of different imaging modalities and discusses appropriate choice of technique in each instance Reviews differential diagnoses and corroborative tests Table of ContentsForeword xiii Preface xv Contributors xvii 1 Adrenal Imaging 1Khaled M. Elsayes, Isaac R. Francis, Melvyn Korobkin and Gerard M. Doherty 1.1 Introduction 1 1.2 Cushing’s syndrome 2 1.3 Primary hyperaldosteronism 5 1.4 Pheochromocytoma 8 1.5 Adrenal cortical carcinoma 12 1.6 Adrenal incidentaloma 15 2 Retroperitoneal Masses 21Pietro Pavlica, Massimo Valentino and Libero Barozzi 2.1 Introduction 21 2.2 Retroperitoneal anatomy 21 2.3 Pathological conditions 22 2.4 Primary solid retroperitoneal tumors 22 2.5 Retroperitoneal lymphoma 27 2.6 Cystic retroperitoneal masses 30 2.7 Retroperitoneal metastases 32 2.8 Retroperitoneal fibrosis (Ormond’s disease) 33 2.9 Retroperitoneal fluid collections (traumatic and non-traumatic) 35 References 41 3 Imaging of Renal Artery Stenosis 43Robert Hartman 3.1 Introduction 43 3.2 Clinical features 43 3.3 Pathology 45 3.4 Imaging of suspected renal artery stenosis 45 References 51 4 Renal Masses 53Philip J. Kenney 4.1 Introduction 53 4.2 Symptomatic renal carcinoma 53 4.3 Incidental renal masses 55 4.4 Patients with a known cancer (other than RCC) 62 4.5 Renal mass in patients with symptoms 63 4.6 Vascular lesions presenting as a renal mass 68 4.7 Renal mass in patients with cystic disease 72 4.8 Treatment 73 References 73 5 Non-neoplastic Renal Cystic Lesions 75Sameh K. Morcos 5.1 Introduction 75 5.2 Classification 75 5.3 Cystic lesions affecting renal cortex 76 5.4 Cystic lesions of renal medulla 80 5.5 Cystic diseases affecting both the cortex and medulla 86 References 97 6 Urological and Vascular Complications Post-renal Transplantation 99Tarek El-Diasty and Yasser Osman 6.1 Introduction 99 6.2 Vascular complications 99 6.3 Urological complications 107 6.4 Ureteric strictures 110 6.5 Post-transplant lymphocele 113 6.6 Delayed graft function (DGF) 116 6.7 Post-transplant bladder malignancy 119 References 120 7 Urinary Tract Injuries 121Elliott R. Friedman, Stanford M. Goldman and Tung Shu 7.1 Introduction 121 7.2 Renal trauma 121 7.3 Adrenal trauma 130 7.4 Ureteral trauma 131 7.5 Bladder trauma 133 7.6 Urethral trauma 136 7.7 Penile and scrotal trauma 142 References 147 8 Urinary Tract Infections 149Mikael Hellström, Ulf Jodal, Rune Sixt and Eira Stokland 8.1 Symptomatic urinary tract infection in children 149 8.2 Symptomatic upper urinary tract infection in adults 167 8.3 Emphysematous pyelonephritis 173 8.4 Xanthogranulomatous pyelonephritis 174 8.5 Urinary tract infection in the immunocompromised patient 177 8.6 Tuberculosis 179 8.7 Schistosomiasis 183 8.8 Hydatid disease (echinococcosis) 188 8.9 Urethritis 191 References 193 9 Imaging of the Genitourinary System – Urolithiasis 195Sami A Moussa and Paramananthan Mariappan 9.1 Introduction 195 9.2 Pathology 195 9.3 Clinical features 197 9.4 Evaluation of patients with suspected urinary stones 198 9.5 Treatment 198 9.6 Imaging 199 References 218 10 Hematuria 219Thomas Bretlau, Kirstine L. Hermann, Jørgen Nordling and Henrik S. Thomsen 10.1 Definition 219 10.2 Clinical considerations 219 10.3 Diagnosis of hematuria 220 10.4 Epidemiology 220 10.5 Distribution of malignancy in patients with hematuria 223 10.6 Imaging 223 10.7 Summary 230 References 234 11 Bladder Cancer 235G. Heinz-Peer and C. Kratzik 11.1 Introduction 235 11.2 Clinical features 237 11.3 Pathology 239 11.4 Imaging findings 243 11.5 Treatment planning 253 11.6 Post-treatment Imaging 254 11.7 Summary 254 References 255 12 Imaging of Urinary Diversion 257Sameh Hanna and Hesham Badawy 12.1 Introduction 257 12.2 Indications for urinary diversion 257 12.3 Types of urinary diversion 257 12.4 Non-continent cutaneous form of diversion 258 12.5 Continent cutaneous urinary diversion (Continent Catheterizing Pouches) 258 12.6 Non-orthotopic continent diversion, relying on the anal sphincter for continence 260 12.7 Orthotopic form of diversion to the native, intact urethra (neobladder) 261 12.8 Contraindications to urinary diversion 264 12.9 Complications of urinary diversions 264 12.10 The role of radiologist in urinary diversion includes 267 12.11 Imaging studies 268 12.12 Imaging of complications 269 12.13 Summary 271 References 271 13 Imaging of the Prostate Gland 273François Cornud 13.1 Introduction 273 13.2 Zonal anatomy and benign prostatic hypertrophy 273 13.3 Diagnosis of prostate cancer: TRUS features 276 13.4 Diagnostic of prostate cancer: MRI 284 13.5 Contrast-enhanced (dynamic) MRI 285 13.6 Magnetic Resonance Spectroscopic Imaging (MRSI) 290 13.7 Diffusion-weighted imaging 292 13.8 Indications of functional MRI 295 13.9 Extension of prostate cancer 297 13.10 Local extension by TRUS and TRUS-guided biopsy 297 13.11 MRI and staging of prostate cancer 298 13.12 Local staging 299 13.13 Lymph node metastases: lympho-MRI 304 13.14 Bone metastases: whole marrow MRI 304 13.15 Benign disorders of the prostate (BPH excluded) 305 References 321 14 Haemospermia 323Drew A. Torigian, Keith N. Van Arsdalen and Parvati Ramchandani 14.1 Introduction 323 14.2 Clinical features 323 14.3 Pathology 325 14.4 Imaging findings 325 14.5 Summary 337 References 337 15 Scrotal Masses 339Lorenzo E. Derchi and Alchiede Simonato 15.1 Introduction 339 15.2 Clinical features 339 15.3 Pathology 340 15.4 Imaging 340 15.5 Important principles in assessment of scrotal masses 341 15.6 Important problems in differentiating benign from malignant lesions 345 References 350 16 Gynaecological Adnexal Masses 351John A. Spencer and Michael J. Weston 16.1 Introduction 351 16.2 Clinical features 351 16.3 Pathology 352 16.4 Imaging 354 16.5 Standard radiographic techniques 355 16.6 Ultrasound (US) 355 16.7 MR Imaging (MRI) 366 16.8 Computed Tomography 373 References 379 17 Imaging of Abnormal Uterine Bleeding 381Patricia Noël, Evis Sala and Caroline Reinhold 17.1 Abnormal uterine bleeding 381 17.2 Adenomyosis 382 17.3 Leiomyomas 385 17.4 Endometrial polyp 389 17.5 Endometrial hyperplasia 391 17.6 Endometrial carcinoma 394 17.7 Summary 396 References 397 18 Female Pelvic Floor Dysfunction 399Rania Farouk El Sayed 18.1 Introduction 399 18.2 Anatomical considerations 399 18.3 Pathophysiology of pelvic floor dysfunction 401 18.4 Clinical features 401 18.5 Imaging of pelvic floor dysfunction 404 18.6 Magnetic resonance imaging (MRI) 407 References 413 19 Imaging of female infertility 415Ahmed-Emad Mahfouz and Hanan Sherif 19.1 Introduction 415 19.2 Polycystic ovary syndrome 415 19.3 Abnormalities of the fallopian tubes (Hydrosalpinx/Hematosalpinx, tubal block) 418 19.4 Fibroids 421 19.5 Adenomyosis 423 19.6 Developmental anomalies of the uterus 424 19.7 Endometriosis 429 19.8 Imaging 430 Index 431
£132.00
John Wiley and Sons Ltd Radiation Biology of Medical Imaging
Book SynopsisThis book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application.Trade Review“This is a very comprehensive text that goes far beyond the content most would expect given the rather specific title.” (Scope, 1 March 2015) Table of ContentsAcknowledgments vii Introduction ix 1 Anatomy and Physiology 1 2 The Cell 19 3 Radiation Characteristics and Units 41 4 Radiation Interactions with Tissue 61 5 Cell Survival Curves 81 6 Dna and Genetics 105 7 Radiation Damage and Repair of Cells 125 8 Normal and Malignant Cells 145 9 Radiation Effects on Tissues and Organs 161 10 Whole Body Radiation Effects 179 11 Radiation Treatment of Cancer 191 12 Radiation Biology of Diagnostic Imaging 203 13 Nuclear Medicine Radiation Biology 219 14 Environmental Radiation 241 15 Regulations and Risk 255 16 Biological Effects of Ultrasound 269 17 Biological Effects of Magnetic Resonance Imaging 281 Answers to Odd-numbered Questions 297 Index 301
£80.06
John Wiley & Sons Inc Advances in Optical Imaging for Clinical Medicine
Book SynopsisThis book provides students, teachers, researchers, and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.Table of ContentsContributors. Preface. 1 Introduction to Optical Imaging in Clinical Medicine (Nicusor Iftimia, Daniel X. Hammer, and William R. Brugge). 2 Traditional Imaging Modalities in Clinical Medicine (Ileana Iftimia and Herbert Mower). 3 Current Imaging Approaches and Further Imaging Needs in Clinical Medicine: A Clinician’s Perspective (Gadi Wollstein and Joel S. Schuman, Cetin Karaca, Sevdenur Cizginer, and William R. Brugge, Ik-Kyung Jang and Jin-Man Cho, Peter K. Dempsey). 4 Advances in Retinal Imaging (Daniel X. Hammer). 5 Confocal Microscopy of Skin Cancers (Juliana Casagrande Tavoloni Braga, Itay Klaz, Alon Scope, Daniel Gareau, Milind Rajadhyaksha, and Ashfaq A. Marghoob). 6 High-Resolution Optical Coherence Tomography Imaging in Gastroenterology (Melissa J. Suter, Brett E. Bouma, and Guillermo J. Tearney). 7 High-Resolution Confocal Endomicroscopy for Gastrointestinal Cancer Detection (Jonathan T. C. Liu, Jonathan W. Hardy, and Christopher H. Contag). 8 High-Resolution Optical Imaging in Interventional Cardiology (Thomas J. Kiernan, Bryan P. Yan, Kyoichi Mizuno, and Ik-Kyung Jang). 9 Fluorescence Lifetime Spectroscopy in Cardio and Neuroimaging (Laura Marcu, Javier A. Jo, and Pramod Butte). 10 Advanced Optical Methods for Functional Brain Imaging: Time-Domain Functional Near-Infrared Spectroscopy (Alessandro Torricelli, Davide Contini, Lorenzo Spinelli, Matteo Caffini, Antonio Pifferi, and Rinaldo Cubeddu). 11 Advances in Optical Mammography (Xavier Intes and Fred S. Azar). 12 Photoacoustic Tomography (Huabei Jiang and Zhen Yuan). 13 Optical Imaging and Measurement of Angiogenesis (Brian S. Sorg). 14 High-Resolution Phase-Contrast Optical Coherence Tomography for Functional Biomedical Imaging (Taner Akkin and Digant P. Davé). 15 Polarization Imaging (Mircea Mujat). 16 Nanotechnology Approaches to Contrast Enhancement in Optical Imaging and Disease-Targeted Therapy (Nicusor Iftimia, Lara Milane, Amy Oldenburg, and Mansoor Amiji). 17 Molecular Probes for Optical Contrast Enhancement of Gastrointestinal Cancers (Jonathan W. Hardy, Anson W. Lowe, Christopher H. Contag, and Jonathan T. C. Liu). Index.
£150.05
John Wiley & Sons Inc ABC of Pleural Diseases
Book SynopsisPleural diseases are very common and of increasing prevalence. This brand new title in the ABC series covers a wide range of conditions including pneumothorax, pleural effusions, pleural infections, chylothorax and mesothelioma.Table of ContentsContributors vii 1 Anatomy and Physiology of the Pleura 1John P. Corcoran and Najib M. Rahman 2 Radiology of Pleural Disease 5Rob J. Hallifax, John P. Corcoran and Najib M. Rahman 3 Pneumothorax 9John Harvey, Andrew McDuff and Ian Hunt 4 Investigation of Pleural Effusions 13Clare E. Hooper 5 Pleural Pathology 21Brendan Tinwell and Ian Hunt 6 Unusual Causes of Pleural Disease 29David Feller]Kopman 7 Pleural Infection 33Ian Hunt and Najib M. Rahman 8 Management of Malignant Pleural Effusions 39Anna C. Bibby, Nick A. Maskell and Rahul Bhatnagar 9 Malignant Mesothelioma 47Carol Tan, Fergus V. Gleeson and Y.C. Gary Lee 10 Pleural Interventions Section A: Pleural Aspiration 53Ambika Talwar, Ahmed Yousuf and Najib M. Rahman Section B: Chest Drain Insertion 56Ahmed Yousuf and Najib M. Rahman Section C: Insertion of an Indwelling Pleural Catheter 60Anna C. Bibby and Nick A. Maskell 11 Medical Thoracoscopy Section A: Rigid Thoracoscopy 63Matthew Evison, Ambika Talwar, Ahmed Yousuf and Mohammed Munavvar Section B: Semi]Rigid Thoracoscopy 69Matthew Evison and Mohammed Munavvar 12 Surgical Management of Pleural Disease 73Stephanie Fraser and Ian Hunt Index 77
£32.95
John Wiley and Sons Ltd Avoiding Errors in Paediatrics
Book SynopsisFor Junior Doctors, Specialty Trainees, and all those involved in hospital governance, this book offers the ultimate real-life guide to help tackle the professional and emotional challenges of life as a doctor in paediatrics. Unlike other clinical management titles, this book identifies and explains the most common and important medical errors.Trade Review“My experience as an expert witness in clinical negligence cases, MPTS Panel chairman, medical adviser to a Public Inquiry and as a sometimes commissioned independent reporter on adverse incidents tells me that these are excellent books, valuable for all clinicians, not just those in high-risk specialties; and all NHS managers involved in maintaining or improving the quality of care. The case vignettes, alone, are useful source material for teaching medical trainees on what can go wrong and how to deal with it when it does.” (Harvey Marcovitch, Clinical Risk journal) "This book is well written and easily read. It is divided into three main parts. The first part deals in general terms with the areas in which errors tend to occur. The importance of good communication, both written and oral, is repeatedly stressed. The contribution of poor management and of system errors in the creation of problems is not overlooked. The section on legal aspects of errors, including discussion of negligence, consent and confidentiality is concise and clear. The second part consists of thirty-six case studies. These are interesting and thought provoking, with questions for the reader at significant points in the progress of each case. An expert opinion, legal comment and key learning points are given at the conclusion of each case. Part 3 gives information and advice on responding to complaints, managing mishaps and navigating the hazards of police, court and GMC involvement. Again it is concise and helpful. After sections 1 and 3, and after every case study in section 2, references and suggestions for further reading are given. I would strongly recommend this book to all paediatricians, at all levels. It is well structured, easy to read and informative. I would also like to see medical and non-medical managers reading it, as it puts into perspective the role of system failures that so often contribute significantly to clinical errors. I think that general practitioners would also find it well worth reading." (Hilary Haines, F.R.C.P.C.H., F.F.P.H.) Pre-publication reviews: “I think in Medicine it is always best to learn from others’ mistakes rather than waiting until you make your own. In addition, knowing what you can expect if a complaint is made goes some way to emphasising the importance of avoiding errors in the first place. Should a complaint be made, forewarned is forearmed.” (ST1 in Paediatrics) “The format of presenting “real life” cases with expert clinical and legal commentary is both entertaining and highly informative.” (Consultant Paediatrician)Table of ContentsContributors, viii Foreword, ix Abbreviations, xi Introduction, xiii Part 1 Section 1: Errors and their causes A few words about error, 1 Learning from system failures – the vincristine case, 1 Person-centred paediatric errors and their causes, 8 The patient consultation, 10 Failure to identify a sick child, 12 Inability to perform practical procedures competently, 13 Failure to check test results or act on abnormal findings, 15 Prescribing errors, 16 Failures in resuscitation, 17 Sources of error in child protection cases, 19 References and further reading, 22 Section 2: Medico-legal aspects Error in a legal context, 25 Negligence, 25 Medical negligence, 26 Issues around consent, 29 Confidentiality, 34 References and further reading, 37 Part 2 Clinical cases Introduction, 39 Case 1 A boy with a limp, 40 Case 2 A fitting infant, 43 Case 3 A persistent fever, 45 Case 4 A biking injury, 48 Case 5 A teenager with abdominal pain, 51 Case 6 A young girl with a vaginal discharge, 54 Case 7 An iatrogenic problem, 57 Case 8 An infant with a large head, 59 Case 9 An infant with bloody diarrhoea, 62 Case 10 An infant with persistent jaundice, 64 Case 11 A child with leukaemia and tummy ache, 66 Case 12 A boy with fever and rigors, 68 Case 13 A stiff hand, 70 Case 14 A serious feeding problem, 72 Case 15 Fits, faints and funny turns, 74 Case 16 A hospital acquired infection, 76 Case 17 Recurrent wheeze, 79 Case 18 A jaundiced neonate, 82 Case 19 A febrile boy with a limp, 85 Case 20 A febrile neonate, 87 Case 21 A neonate with abnormal movements, 89 Case 22 A teenager with scrotal pain, 91 Case 23 A boy with nonspecific symptoms, 93 Case 24 A delayed walker, 96 Case 25 A diabetic girl with a headache, 98 Case 26 A boy with sickle cell disease and a fever, 101 Case 27 Negative test results, 104 Case 28 A bad case of ‘flu, 107 Case 29 A difficult transfer, 110 Case 30 Treatment for tonsillitis, 112 Case 31 Increasing respiratory distress, 114 Case 32 A feverish girl with poor feeding, 116 Case 33 An infant with a swollen face, 118 Case 34 Starting a new treatment, 121 Case 35 The importance of interpretation, 124 Case 36 A febrile boy with a scald, 126 Part 3 Investigating and dealing with errors 1 Introduction, 129 2 How hospitals try to prevent errors and their recurrence, 129 3 The role of hospital staff, 134 4 External investigators, 136 5 Hospital investigations, 138 6 Legal advice – where to get it and how to pay, 143 7 External inquiries, 146 8 The role of the doctor, 165 9 Emotional repercussions, 167 10 Conclusion, 169 References and further reading, 169 Index, 171
£44.04
John Wiley and Sons Ltd Diagnostic Imaging Includes Wiley EText
Book SynopsisThis book helps readers understand the principles of interpretation of all forms of imaging. It is an introductory textbook that provides a balanced account of all the imaging modalities available to the practicing clinician, explaining the techniques used and the indications for their use.Trade Review“Overall, this is a useful introduction to radiology for medical students and interns. It is helpful to have one reference for a number of modalities for various types of organ imaging and for many different medical conditions, although it does underemphasize the value of radionuclide techniques.” (Doody’s, 16 August 2013)Table of ContentsPreface vii Acknowledgements viii List of Abbreviations ix The Anytime, Anywhere Textbook x 1 Technical Considerations 1 2 Chest 19 3 Cardiac Disorders 101with the assistance of Dr Francesca Pugliese 4 Breast Imaging 123with the assistance of Dr Sarah Vinnicombe 5 Plain Abdomen 129 6 Gastrointestinal Tract 141 7 Hepatobiliary System, Spleen and Pancreas 195 8 Urinary Tract 223 9 Female Genital Tract 273 10 Peritoneal Cavity and Retroperitoneum 291 11 Bones 309with the assistance of Dr Kasthoori Jayarani 12 Joints 347with the assistance of Dr Kasthoori Jayarani 13 Spine 369with the assistance of Dr Rob Barker 14 Skeletal Trauma 399with the assistance of Dr Muaaze Ahmad 15 Brain 427with the assistance of Dr Rob Barker 16 Orbits, Head and Neck 457with the assistance of Dr Polly Richards 17 Vascular and Interventional Radiology 471 Appendix: Computed Tomography Anatomy of the Abdomen 491 Index 497
£999.99
John Wiley & Sons Inc Ethical Issues in Forensic Psychiatry
Book SynopsisEthical medical practice and treatment in psychiatry are based on the concept of first do no harm. However, this cannot, and does not, apply to forensic cases where there is no doctorpatient relationship and the forensic psychiatrist may indeed cause harm to the examinee. In this book, Robert Sadoff analyzes the ethical issues affecting forensic psychiatric practice, especially those promulgated by the American Academy of Psychiatry and the Law. Within those guidelines, he looks at individual bias, vulnerability of the examinee, and potential harm to the mental health professional. The book discusses each of the procedures of the forensic expert separately with respect to minimizing harm. It has been written with an international audience in mind and features chapters reviewing the European and UK perspectives, by Emanuele Valenti and John Baird, respectively. Robert Sadoff addresses the long-term harm that can be either avoided or minimized through careful planning and applicationTrade Review"Sadoff's book is a vital contribution to the psychiatric literature, as it fills a need unaddressed by more theoretically oriented works. Anyone interested in mental health or medical ethics will find this text worthwhile, especially as it contains an introduction for lay readers explaining basic forensic roles and functions.The book is most valuable, however, to forensic mental health practioners, who will benefit from its practical instruction aimed at minimizing harm." (Journal of Clinical Psychiatry, December 2012) "Sadoff has crafted an admirable mix of facts and anecdotes, presented in a manner that could help undergraduates get a taste for the realities of forensic practice, help graduate students connect the theoretical with the practical, and even provide veteran practitioners with helpful reminders and provocative food for thought." (PsycCRITIQUES, 23 November 2011) "It will serve as a useful resource and is a welcome addition to my library." (Doody's, 11 November 2011) "While Ethical Issues in Forensic Psychiatry appears to be targeted at the forensic psychiatrist, as emphasised in the title, I believe that it can be valuable reading for all forensic mental health professionals. . . Ethical Issues in Forensic Psychiatry makes practical ethics easy reading. . . This book is an invaluable guide to ethical practice." (Journal of Mental Health, 1 October 2011) Table of ContentsAbout the Authors. Preface. Acknowledgments. Introduction. List of Contributors. Part One Ethics in Forensic Psychiatry. 1 Ethical Issues in Forensic Psychiatry in the United States (Robert L. Sadoff). 2 Minimizing Harm: A Perspective from Forensic Psychiatry in the United Kingdom (John A. Baird). 3 Mental Health and Human Rights in Forensic Psychiatry in the European Union (Emanuele Valenti and Luis Fernando Barrios Flores). Part Two The Practice of Forensic Psychiatry. 4 The Forensic Psychiatric Examination (Robert L. Sadoff). 5 The Forensic Psychiatric Report (Robert L. Sadoff). 6 Expert Psychiatric Testimony (Robert L. Sadoff). Part Three Vulnerable Populations in the Justice System. 7 Children and Adolescents (Robert L. Sadoff). 8 The Elderly, the Mentally Retarded, and the Severely Mentally Disabled (Robert L. Sadoff). 9 Victims and Predators of Sexual Violence (Robert L. Sadoff). 10 Immigrants: A Vulnerable Population (Solange Margery Bertoglia). 11 Prisoners and Death Row Inmates (Robert L. Sadoff). 12 Forensic Psychiatric Experts: Risks and Liability (Robert L. Sadoff). 13 Risks of Harm to the Forensic Expert: the Legal Perspective (Donna L. Vanderpool). Index.
£60.75
John Wiley and Sons Ltd Food Allergy
Book SynopsisFood Allergy is a unique book which uses a scientific approach to cover both pediatric and adult adverse reactions to foods and food additives. Following the successful formula of the previous editions, Food Allergy has established itself as the comprehensive reference for those treating patients with food allergy or suspected allergy. This fifth edition has been thoroughly revised and updated. It is a practical, readable reference for use in the hospital or private practice setting. Each of the chapters is capable of standing alone, but when placed together they present a mosaic of the current ideas and research on adverse reactions to foods and food additives. The book covers basic and clinical perspectives of adverse reactions to food antigens, adverse reactions to food additives and contemporary topics, including a review of the approaches available for diagnosis. Food Allergy is directed toward clinicians, nutritionists and scientists interestTrade Review"Food Allergy: Adverse Reactions to Foods and Food Additives will be a welcome addition to libraries serving clinicians, nutritionists, dieticians and persons with food allergies or parents of children with food allergies." (Reference Reviews, 1 April 2015)Table of ContentsList of Contributors, vii Preface, xi Abbreviations, xiii Part 1 Adverse Reactions to Food Antigens: Basic Science 1 The Mucosal Immune System, 3 Shradha Agarwal & Lloyd Mayer 2 The Immunological Basis of IgE-Mediated Reactions, 16 Stephan C. Bischoff & Gernot Sellge 3 The Immunological Basis of Non-IgE-Mediated Reactions, 31 Ashraf Uzzaman & Hirsh D. Komarow 4 Food Allergens—Molecular and Immunological Characteristics, 47 Heimo Breiteneder & E.N. Clare Mills 5 Biotechnology and Genetic Engineering, 68 Gary A. Bannon, Jason M. Ward, Raymond C. Dobert, & Roy L. Fuchs 6 Food Allergen Thresholds of Reactivity, 90 Steve L. Taylor, Jonathan O’B. Hourihane, & Joseph L. Baumert 7 Immunological Tolerance, 100 Lauren Steele & M. Cecilia Berin 8 In Vitro Diagnostic Methods in the Evaluation of Food Hypersensitivity, 110 Robert G. Hamilton Part 2 Adverse Reactions to Food Antigens: Clinical Science 9 Theories on the Increasing Prevalence of Food Allergy, 123 Katrina J. Allen & Jennifer J. Koplin 10 The Spectrum of Allergic Reactions to Foods, 134 Stacie M. Jones & A. Wesley Burks 11 Cutaneous Reactions: Atopic Dermatitis and Other IgE- and Non-IgE-Mediated Skin Reactions, 144 David M. Fleischer & Donald Y.M. Leung 12 Oral Allergy Syndrome, 158 Julie Wang 13 The Respiratory Tract and Food Hypersensitivity, 169 Graham Roberts 14 Anaphylaxis and Food Allergy, 178 Hugh A. Sampson 15 Infantile Colic and Food Allergy, 192 Ralf G. Heine & David J. Hill 16 Eosinophilic Esophagitis, Gastroenteritis, and Colitis, 203 Amanda Muir & Chris A. Liacouras 17 Gluten-Sensitive Enteropathy, 217 Alberto Rubio-Tapia & Joseph A. Murray 18 Food Protein-Induced Enterocolitis and Enteropathies, 230 Jay A Lieberman & Anna Nowak-Wegrzyn 19 Occupational Reactions to Food Allergens, 245 Andre Cartier, Sangeeta J. Jain, Laurianne G. Wild, Maxcie Sikora, Matthew Aresery, & Samuel B. Lehrer Part 3 Adverse Reactions to Foods: Diagnosis 20 IgE Tests: In Vitro Diagnosis, 269 Kirsten Beyer 21 In Vivo Diagnosis: Skin Testing and Challenge Procedures, 278 Scott H. Sicherer 22 Atopy Patch Testing for Food Allergies, 289 Von Ta & Kari Nadeau 23 Elimination Diets and Oral Food Challenges, 296 Scott H. Sicherer 24 General Approach to Diagnosing Food Allergy and the Food Allergy Guidelines, 306 Jonathan O’B. Hourihane & Hugh A. Sampson 25 Hidden and Cross-Reacting Food Allergens, 316 Scott H. Sicherer 26 Controversial Practices and Unproven Methods in Allergy, 328 David R. Scott, Jennifer A. Namazy, & Ronald A. Simon Part 4 Adverse Reactions to Food Additives 27 Asthma and Food Additives, 341 Robert K. Bush & Michelle Montalbano 28 Urticaria, Angioedema, and Anaphylaxis Provoked by Food Additives, 346 John V. Bosso & David M. Robertson 29 Sulfites, 361 Steve L. Taylor, Robert K. Bush, & Julie A. Nordlee 30 Monosodium Glutamate, 375 Katharine M. Woessner 31 Tartrazine, Azo, and Non-Azo Dyes, 384 Donald D. Stevenson 32 Adverse Reactions to the Antioxidants Butylated Hydroxyanisole and Butylated Hydroxytoluene, 393 Richard W. Weber 33 Adverse Reactions to Benzoates and Parabens, 402 Raymond M. Pongonis & John M. Fahrenholz 34 Food Colorings and Flavors, 411 Matthew J. Greenhawt & James L. Baldwin Part 5 Contemporary Topics in Adverse Reactions to Foods 35 Pharmacologic Food Reactions, 439 Timothy J. Franxman & James L. Baldwin 36 The Management of Food Allergy, 452 Maria Laura Acebal, Anne Mu˜ noz-Furlong, & Hugh A. Sampson 37 The Natural History of Food Allergy, 464 Robert A. Wood 38 Prevention of Food Allergy, 475 Gideon Lack & George Du Toit 39 Diets and Nutrition, 492 Marion Groetch 40 Food Toxicology, 507 Steve L. Taylor 41 Seafood Toxins, 518 Soheil Chegini, Sarah J. Austin, & Dean D. Metcalfe 42 Neurologic Reactions to Foods and Food Additives 535 Richard W. Weber 43 Experimental Approaches to the Study of Food Allergy, 547 M. Cecilia Berin & Madhan Masilamani 44 Food Allergy: Psychological Considerations and Quality of Life, 556 Ma. Lourdes B. de Asis & Ronald A. Simon 45 Foods and Rheumatologic Diseases, 568 Lisa K. Stamp & Leslie G. Cleland 46 Approaches to Therapy in Development, 581 Anna Nowak-W_egrzyn & Hugh A. Sampson Index, 599
£178.55
John Wiley & Sons Inc Bipolar Disorder
Book SynopsisBipolar Disorder Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant comorbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is both relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have Trade Review"...The textbook is also an ideal starting point for trainees and young investigators just beginning to explore these subjects. Biopolar Disorder: Clinical and Neurobiological Foundations, then, is a useful addition to the library of most clinicians and academic psychiatrists" (Journal of Clinical Psychiatry, 2011) "The book is a valuable guide to every psychiatrist. It contains a rich and wide range of information about bipolar disorder, step by step from criteria and definitions through biological changes to medical and psychotherapeutic treatment. The reader gets an overview over the newest findings which are presented in a very accessible way. It is definitely a book necessary for each modern psychiatrist!" (Acta Psychiatrica Scandinavica, 2011) "Contributors to 38 chapters offer international perspectives on the disorder's clinical and neurobiological foundations as defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases." (SciTech Book News, December 2010) Table of ContentsPreface. List of Contributors. 1 From Mania to Bipolar Disorder (David Healy). 2 Clinical Features and Subtypes of Bipolar Disorder (Fred K. Goodwin and D.Z. Lieberman). 3 The Long-Term Course and Clinical Management of Bipolar I and Bipolar II Disorders (Lewis L. Judd and Pamela J. Schettler). 4 Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders (Mark A. Frye and Giulio Perugi). 5 DSM-V Perspectives on Classification of Bipolar Disorder (Jan Fawcett). 6 Update on the Epidemiology of Bipolar Disorder (Kathleen R. Merikangas and Tracy L. Peters). 7 Suicide and Bipolar Disorder (Zoltan Rihmer and Jan Fawcett). 8 Neurocognition in Bipolar Disorder (Ivan J. Torres and Gin S. Malhi). 9 The Genius-Insanity Debate: Focus on Bipolarity, Temperament, Creativity and Leadership (Hagop S. Akiskal and Kareen K. Akiskal). 10 Economics of Bipolar Disorder (R. Sabes-Figuera, D. Razzouk and Paul E. McCrone). 11 An Introduction to the Neurobiology of Bipolar Illness Onset, Recurrence and Progression (Robert M. Post and Marcia Kauer-Sant.Anna). 12 Genetics of Bipolar Disorder (Falk W. Lohoff and Wade H. Berrettini). 13 Structural Brain Imaging in Bipolar Disorder (Paolo Brambilla and Jair C. Soares). 14 Functional Magnetic Resonance Imaging, Diffusion Tensor Imaging, and Magnetic Resonance Spectroscopy in Bipolar Disorder (In Kyoon Lyoo and Perry F. Renshaw). 15 Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow (John O. Brooks III, Po W. Wang and Terence A. Ketter). 16 Neurotransmitter Systems in Bipolar Disorder (Marina Nakic, John H. Krystal and Zubin Bhagwagar). 17 Molecular Biology of Bipolar Disorder (Ana Andreazza, Jun Feng Wang and Trevor Young). 18 Mitochondrial Dysfunction and Oxidative Stress (Tadafumi Kato, Flavio Kapczinski and Michael Berk). 19 Neuroendocrinology of Bipolar Illness (Timothy Dinan and Michael Bauer). 20 Circadian Rhythms and Sleep in Bipolar Disorder (Greg Murray and Allison Harvey). 21 Treatment Adherence in Bipolar Disorder (Jan Scott and Mary Jane Tacchi). 22 Acute Mania (Paul E. Keck, Jr, Susan L. McElroy and John M. Hawkins). 23 Pharmacological Treatment of Bipolar Depression (Allan H. Young and Charles B. Nemeroff). 24 Practical Pharmacological Maintenance Treatment of Bipolar Disorder (Alan C. Swann). 25 Rapid Cycling Bipolar Disorder: Phenomenology and Treatment (Joseph F. Goldberg and Michael Berk). 26 Management of Bipolar II Disorder (Gordon Parker and Terence A. Ketter). 27 Management of Comorbidity in Bipolar Disorder (Ihsan M. Salloum, Luca Pani and Tiffany Cooke). 28 Bipolar Disorder and Safety Monitoring for Clinicians: A Review of the Evidence and the Implications (Chris J. Bushe and Mauricio Tohen). 29 Somatic Treatments for Bipolar Disorder: ECT, VNS and TMS (Mark S. George). 30 Novel Therapeutic Strategies for Bipolar Disorder (Rodrigo Machado-Vieira, Husseini K. Manji and Carlos A. Zarate Jr). 31 Psychoeducation as a Core Element of Psychological Approaches for Bipolar Disorders (Francesc Colom and Lesley Berk). 32 Cognitive-Behavioural Therapy for Bipolar Disorder (Sagar V. Parikh and Jan Scott). 33 Interpersonal and Social Rhythm Therapy for Bipolar Disorder (Holly A. Swartz, Ellen Frank, Laura E. Zajac and David J. Kupfer). 34 Family Therapy Approaches to Bipolar Disorder (David J. Miklowitz). 35 Collaborative Care for Bipolar Disorder (Amy M. Kilbourne, David E. Goodrich and Mark S. Bauer). 36 Bipolar Disorder in Women (Benicio N. Frey, Karine A. Macritchie, Claudio N. Soares and Meir Steiner). 37 Phenomenology and Treatment of Bipolar I Disorder in Children: A Critical Review (Gabrielle A. Carlson and Elizabeth B. Weller). 38 Bipolar Disorder in the Elderly (Martha Sajatovic and Lars Vedel Kessing). Index.
£180.95
John Wiley & Sons Inc Bipolar Psychopharmacotherapy
Book SynopsisBipolar Psychopharmacotherapy covers both pharmacotherapy and the role of psychotherapy, psychoeducation, and social approaches to provide a broad integrative philosophy of care for bipolar patients.Trade Review“This is an interesting, easy to read, and informative book that presents research treatment outcome data to support treatment direction and choices. Anything one needs to know about bipolar disorder is thoroughly covered. This is a book psychiatrists, psychologists, social workers, nurses, doctors of pharmacy, residents, students in medical training programs, patients, and their families may find helpful in understanding the complexities and available treatment choices and their limitations. With the continuing research, this update is justified, and a third edition will soon be needed to keep current.” (Doddy's, 20 April 2012) Table of ContentsList of Contributors. Preface to the Second Edition. Chapter 1 The scope of bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment: Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1 Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and better prophylactic agents about to oust lithium? 2.6 Combination treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical background. 3.2 Structure–activity relationships. 3.3 Pharmacodynamic properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate in treatment of bipolar disorder in children and adolescents. 3.12 Use in bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid with ADHD. 3.14 Bipolar disorder comorbid with borderline personality disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17 Adverse effects in combination therapy, compared with monotherapy. 3.18 Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological profile and clinical utility of lamotrigine in mood disorders (Marc L.M. van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina). 4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter 6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the clinical trial development of olanzapine. 6.3 Efficacy in the treatment of acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5 Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute tranquillization in mania. 7.3 Sedation is not required for antipsychotics to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania. 7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics. 7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in mania. 7.9 Recent comparative trials without placebo. 7.10 Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9 Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4 Risperidone long-acting injectable (LAI) in the maintenance treatment of bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz, Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology. 10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine. 10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder (Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N. Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance treatment of bipolar disorder. 11.8 Practical guidance on the use of ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10 Treatment of special populations. 11.11 Summary and conclusions. Chapter 12 Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1 Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4 Aripiprazole safety and tolerability. 12.5 Treatment of special populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology. 13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and mixed states. 13.5 Asenapine: Efficacy and tolerability during extension treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1 Introduction. 14.2 Rationale for complex combination therapy in bipolar illness. 14.3 Principles of building an effective therapeutic regimen. 14.4 Conclusions. Chapter 15 The role of antidepressants in bipolar disorder (Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants. 15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine, duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications. Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy, Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2 Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender differences in phenomenology. 16.4 Gender differences in course and outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8 Summary. Chapter 17 Pediatric bipolar disorder: The promise of psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1 Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5 Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I. Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar disorder in old age. 18.2 Management of bipolar disorder in the elderly. 18.3 Treatment of bipolar depression in older adults. 18.4 The future. Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1 What is a mixed state? 19.2 General considerations for treatment strategies in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20 Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F. Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2 Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4 Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion. Chapter 21 Novel therapeutic approaches for treating bipolar disorder (Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov, Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2 The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4 The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final remarks. Chapter 22 The pivotal role of psycho-education in the long-term treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1 Introduction. 22.2 On the need for psycho-education. 22.3 The five ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5 Early warning signs – detection. 22.6 Lifestyle regularity (and miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments. Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment according to phase and severity of illness. 23.2 Pretreatment evaluation and monitoring of pharmacotherapy. 23.3 Drug response and treatment setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar illness. Chapter 24 Pharmacological prevention of suicide in bipolar patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders. 24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K. Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder. 25.3 Principles of caring. 25.4 Special considerations for hypomanic and cyclothymic patients. 25.5 Conclusion. References. Index.
£108.95
John Wiley & Sons Inc Genetic and Evolutionary Computation
Book SynopsisGenetic and Evolutionary Computation: Medical Applications provides an overview of the range of GEC techniques being applied to medicine and healthcare in a context that is relevant not only for existing GEC practitioners but also those from other disciplines, particularly health professionals. There is rapidly increasing interest in applying evolutionary computation to problems in medicine, but to date no text that introduces evolutionary computation in a medical context. By explaining the basic introductory theory, typical application areas and detailed implementation in one coherent volume, this book will appeal to a wide audience from software developers to medical scientists. Centred around a set of nine case studies on the application of GEC to different areas of medicine, the book offers an overview of applications of GEC to medicine, describes applications in which GEC is used to analyse medical images and data sets, derive advanced models, and suggest diagnoses and Table of ContentsAbout the Editors. List of Contributors. 1 Introduction. 2 Evolutionary Computation: A Brief Overview (Stefano Cagnoni and Leonardo Vanneschi). 2.1 Introduction. 2.2 Evolutionary Computation Paradigms. 2.2.1 Genetic Algorithms. 2.2.2 Evolution Strategies. 2.2.3 Evolutionary Programming. 2.2.4 Genetic Programming. 2.2.5 Other Evolutionary Techniques. 2.2.6 Theory of Evolutionary Algorithms. 2.3 Conclusions. 3 A Review of Medical Applications of Genetic and Evolutionary Computation (Stephen L. Smith). 3.1 Medical Imaging and Signal Processing. 3.1.1 Overview. 3.1.2 Image Segmentation. 3.1.3 Image Registration, Reconstruction and Correction. 3.1.4 Other Applications. 3.2 Data Mining Medical Data and Patient Records. 3.3 Clinical Expert Systems and Knowledge-based Systems. 3.4 Modelling and Simulation of Medical Processes. 3.5 Clinical Diagnosis and Therapy. 4 Applications of GEC in Medical Imaging. 4.1 Evolutionary Deformable Models for Medical Image Segmentation: A Genetic Algorithm Approach to Optimizing Learned, Intuitive, and Localized Medial-based Shape Deformation (Chris McIntosh and Ghassan Hamarneh). 4.1.1 Introduction. 4.1.1.1 Statistically Constrained Localized and Intuitive Deformations. 4.1.1.2 Genetic Algorithms. 4.1.2 Methods. 4.1.2.1 Population Representation. 4.1.2.2 Encoding the Weights for GAs. 4.1.2.3 Mutations and Crossovers. 4.1.2.4 Calculating the Fitness of Members of the GA Population. 4.1.3 Results. 4.1.4 Conclusions. 4.2 Feature Selection for the Classification of Microcalcifications in Digital Mammograms using Genetic Algorithms, Sequential Search and Class Separability (Santiago E. Conant-Pablos, Rolando R. Hernández-Cisneros, and Hugo Terashima-Marín). 4.2.1 Introduction. 4.2.2 Methodology. 4.2.2.1 Pre-processing. 4.2.2.2 Detection of Potential Microcalcifications (Signals). 4.2.2.3 Classification of Signals into Microcalcifications. 4.2.2.4 Detection of Microcalcification Clusters. 4.2.2.5 Classification of Microcalcification Clusters into Benign and Malignant. 4.2.3 Experiments and Results. 4.2.3.1 From Pre-processing to Signal Extraction. 4.2.3.2 Classification of Signals into Microcalcifications. 4.2.3.3 Microcalcification Clusters Detection and Classification. 4.2.4 Conclusions and Future Work. 4.3 Hybrid Detection of Features within the Retinal Fundus using a Genetic Algorithm (Vitoantonio Bevilacqua, Lucia Cariello, Simona Cambo, Domenico Daleno, and Giuseppe Mastronardi). 4.3.1 Introduction. 4.3.2 Acquisition and Processing of Retinal Fundus Images. 4.3.2.1 Retinal Image Acquisition. 4.3.2.2 Image Processing. 4.3.3 Previous Work. 4.3.4 Implementation. 4.3.4.1 Vasculature Extraction. 4.3.4.2 A Genetic Algorithm for Edge Extraction. 4.3.4.3 Skeletonization Process. 4.3.4.4 Experimental Results. 5 New Analysis of Medical Data Sets using GEC. 5.1 Analysis and Classification ofMammography Reports using Maximum Variation Sampling (Robert M. Patton, Barbara G. Beckerman, and Thomas E. Potok). 5.1.1 Introduction. 5.1.2 Background. 5.1.3 Related Works. 5.1.4 Maximum Variation Sampling. 5.1.5 Data. 5.1.6 Tests. 5.1.7 Results & Discussion. 5.1.8 Summary. 5.2 An Interactive Search for Rules in Medical Data using Multiobjective Evolutionary Algorithms (Daniela Zaharie, D. Lungeanu, and Flavia Zamfirache). 5.2.1 Medical Data Mining. 5.2.2 Measures for Evaluating the Rules Quality. 5.2.2.1 Accuracy Measures. 5.2.2.2 Comprehensibility Measures. 5.2.2.3 Interestingness Measures. 5.2.3 Evolutionary Approaches in Rules Mining. 5.2.4 An Interactive Multiobjective Evolutionary Algorithm for Rules Mining. 5.2.4.1 Rules Encoding. 5.2.4.2 Reproduction Operators. 5.2.4.3 Selection and Archiving. 5.2.4.4 User Guided Evolutionary Search. 5.2.5 Experiments in Medical Rules Mining. 5.2.5.1 Impact of User Interaction. 5.2.6 Conclusions. 5.3 Genetic Programming for Exploring Medical Data using Visual Spaces (Julio J. Valdés, Alan J. Barton, and Robert Orchard). 5.3.1 Introduction. 5.3.2 Visual Spaces. 5.3.2.1 Visual Space Realization. 5.3.2.2 Visual Space Taxonomy. 5.3.2.3 Visual Space Geometries. 5.3.2.4 Visual Space Interpretation Taxonomy. 5.3.2.5 Visual Space Characteristics Examination. 5.3.2.6 Visual Space Mapping Taxonomy. 5.3.2.7 Visual Space Mapping Computation. 5.3.3 Experimental Settings. 5.3.3.1 Implicit Classical Algorithm Settings. 5.3.3.2 Explicit GEP Algorithm Settings. 5.3.4 Medical Examples. 5.3.4.1 Data Space Examples. 5.3.4.2 Semantic Space Examples. 5.3.5 Future Directions. 6 Advanced Modelling, Diagnosis and Treatment using GEC. 6.1 Objective Assessment of Visuo-spatial Ability using Implicit Context Representation Cartesian Genetic Programming (Michael A. Lones and Stephen L. Smith). 6.1.1 Introduction. 6.1.2 Evaluation of Visuo-spatial Ability. 6.1.3 Implicit Context Representation CGP. 6.1.4 Methodology. 6.1.4.1 Data Collection. 6.1.4.2 Evaluation. 6.1.4.3 Parameter Settings. 6.1.5 Results. 6.1.6 Conclusions. 6.2 Towards an Alternative to Magnetic Resonance Imaging for Vocal Tract Shape Measurement using the Principles of Evolution (David M. Howard, Andy M. Tyrrell, and Crispin Cooper). 6.2.1 Introduction. 6.2.2 Oral Tract Shape Evolution. 6.2.3 Recording the Target Vowels. 6.2.4 Evolving Oral Tract Shapes. 6.2.5 Results. 6.2.5.1 Oral Tract Areas. 6.2.5.2 Spectral Comparisons. 6.2.6 Conclusions. 6.3 How Genetic Algorithms can Improve Pacemaker Efficiency (Laurent Dumas and Linda El Alaoui). 6.3.1 Introduction. 6.3.2 Modeling of the Electrical Activity of the Heart. 6.3.3 The Optimization Principles. 6.3.3.1 The Cost Function. 6.3.3.2 The Optimization Algorithm. 6.3.3.3 A New Genetic Algorithm with a Surrogate Model. 6.3.3.4 Results of AGA on Test Functions. 6.3.4 A Simplified Test Case for a Pacemaker Optimization. 6.3.4.1 Description of the Test Case. 6.3.4.2 Numerical Results. 6.3.5 Conclusion. 7 The Future for Genetic and Evolutionary Computation in Medicine: Opportunities, Challenges and Rewards. 7.1 Opportunities. 7.2 Challenges. 7.3 Rewards. 7.4 The Future for Genetic and Evolutionary Computation in Medicine. Appendix: Introductory Books and Useful Links. Index.
£100.65
John Wiley & Sons Inc Polysaccharide Building Blocks
Book SynopsisThis book is an archival reference for the evolving field of biomaterials and their applications in society, focusing on their composition, properties, characterization, chemistry and applications in bioenergy, chemicals, and novel materials and biomaterials.It has broad appeal due to the recent heightened awareness around bioenergy and biomass as potential replacements for petroleum feedstocks.The book is divided into three parts: cellulose-based biomaterials, chitin and chitosan biomaterials, and hemicelluloses and other polysaccharides. Each chapter addresses a separate biomaterial, discussing its chemical, physical, and biological attributes, and hones in on each compound''sintrinsic tunabilityfor numerous chemical transformations.In the current quest for a green economy and resources, this book will help inspire scientists towardsnovel sources for chemicals, materials, andenergy in the years to come.Table of ContentsForeword vii Preface ix Contributors xi 1 Recent Advances in Cellulose Chemistry 1 Thomas Heinze and Katrin Petzold-Welcke 2 Cellulosic Aerogels 51 Falk Liebner, Emmerich Haimer, Antje Potthast, and Thomas Rosenau 3 Nanocelluloses: Emerging Building Blocks for Renewable Materials 105 Youssef Habibi and Lucian A. Lucia 4 Interactions of Chitosan with Metals for Water Purification 127 Mohammed Rhazi, Abdelouhad Tolaimate, and Youssef Habibi 5 Recent Developments in Chitin and Chitosan Bio-Based Materials Used for Food Preservation 143 Véronique Coma 6 Chitin and Chitosan as Biomaterial Building Blocks 177 JoséF. Louvier-Hernández and Ram B. Gupta 7 Chitosan Derivatives for Bioadhesive/Hemostatic Applications: Chemical and Biological Aspects 199 Mai Yamazaki and Samuel M. Hudson 8 Chitin Nanofibers as Building Blocks for Advanced Materials 227 Youssef Habibi and Lucian A. Lucia 9 Electrical Conductivity and Polysaccharides 247 Axel Rußler and Thomas Rosenau 10 Polysaccharide-Based Porous Materials 271 Peter S. Shuttleworth, Avtar Matharu, and James H. Clark 11 Starch-Based Bionanocomposites: Processing and Properties 287 Visakh P. M., Aji P. Mathew, Kristiina Oksman, and Sabu Thomas 12 Starch-Based Sustainable Materials 307 Luc Avérous 13 The Potential of Xylans as Biomaterial Resources 331 Anna Ebringerova 14 Micro- and Nanoparticles from Hemicelluloses 367 Emmerich Haimer, Falk Liebner, Antje Potthast, and Thomas Rosenau 15 Nonxylan Hemicelluloses as a Source of Renewable Materials 387 David Plackett and Natanya Hansen Index 409
£120.60
John Wiley and Sons Ltd Liver Imaging
Book Synopsis* The first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world s leading authorities in abdominal imaging, Richard C. Semelka MD.Table of ContentsList of Contributors, vii Preface, ix 1 The Cross-Sectional Anatomy of the Liver and Normal Variations1Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 2 The Cross-Sectional Imaging Techniques and Diagnostic Approach 15Ersan Altun and Richard C. Semelka 3 Safety of MRI and CT 63Ersan Altun and Richard C. Semelka 4 Cystic Diseases of the Liver 73Ersan Altun, Mohamed, El-Azzazi, Richard C. Semelka, and Miguel Ramalho 5 Benign Solid Liver Lesions 101Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 6 Liver Metastases 137Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Miguel Ramalho 7 Hepatocellular Carcinoma 161Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 8 Rare Primary and Secondary Tumors of the Liver 181Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 9 Cholangiocarcinoma 193Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Miguel Ramalho 10 Infectious Diseases of the Liver, 201Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 11 Chronic Hepatitis and Liver Cirrhosis 219Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 12 Hepatic Fat and Iron Deposition 241Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 13 Inflammatory Liver Diseases 255Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 14 Vascular Disorders of the Liver 267Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 15 Post-treatment Changes in the Liver 285Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 16 Liver Trauma 301Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka Index 305
£124.40
John Wiley & Sons Inc Handbook of Child and Adolescent Psychiatry
Book SynopsisThis volume contains information on assessing, diagnosing and treatment planning for the range of psychiatric and psychologic problems children and adolescents may experience during their development. It includes in-depth coverage of these issues and also includes decision trees for some topics, which are brief flowcharts for practitioners to follow when assessing patients for suspected problems.Table of ContentsCLINICAL ASSESSMENT. Types and Goals of Clinical Assessment (M. Dulcan). Classification Systems and Nosology (T. Achenbach). Vulnerabilities, Risk Factors, Protective Factors, and Resilience (N. Grant). Communicating with Children (J. Demb & S. Harrison). Communicating with Adolescents (R. Hendren & B. Sarvet). Engaging Parents in Clinical Processes (S. Brown). Clinical Use of Interpreters (W. Arroyo). Experimental Concepts in Clinical Assessment (K. Wells). The Ethics of Consent and Confidentiality in Clinical Practice (G. Leong & S. Eth). DECISION TREES FOR A SAMPLING OF PRESENTING PROBLEMS. Disruptive Behavior (P. Tolan & M. Kruesi). Shyness and Fearfulness (R. Mattison). Unhappiness (J. Bemporad & S. Gabel). Difficulty with Academic Performance (L. Silver & R. Ostrander). Sleep Difficulty (M. Naylor). Appetite Disturbances: Anorexia and Hyperphagia (H. Steiner). Substance Abuse (S. Jaffe & J. Gould). Suicidal Behavior (C. Pfeffer). Bizarre, Odd, and Eccentric Behavior (P. Tanguay). Enuresis (G. Fritz & R. Rockney). Encopresis (R. Rockney & O. Hagino). School Refusal (R. Klein). Lying (E. Bleiberg & S. Atkinson). Stealing (E. Bleiberg & S. Atkinson). Temper Tantrums (S. Brown & H. Reid). Speech and Language Disorders (L. Zukerman & D. Cantwell). Language Delay (J. Fischel & G. Whitehurst). Accident-Proneness (M. Sokol & N. Gray). No Friends (A. Clarkin). Runaway Behavior (J. Sargent). Involuntary Movements (B. Peterson). INITIATING ASSESSMENT. The Initial Encounter (R. King). Assessment of Dangerousness (J. Jankowski). CLINICAL HISTORY. Psychiatric History (M. Dulcan). Genetic, Prenatal, and Delivery History (L. Lotspeich). Neonatal and Infancy History (K. Minde). Preschool History (K. Minde). History of School-Age Children (R. King). Puberty and Adolescence (C. Sylvester & S. Weissman). Temperament and Personality (R. Seifer). Speech, Language, and Communication (C. Baltaxe). Health History (H. Steiner). Nutrition Assessment (P. Novak & M. Baer). Assessment of Gender and Sexual Development in Children (S. Coates & S. Wolfe. Assessment of Sexual and Gender Development in Adolescents (S. Bradley). Assessment of Conscience Development (C. Keith). Assessment of Cognitive Processes (D. Siegel). Social Communication (P. Tanguay). Family History (A. Josephson & F. Moncher). Peer and Adult Relationships (A. Clarkin). Socioeconomic Factors (E. Messinger). Legal Factors (D. Cornell). Cultural and Religious Issues (P. Muehrer). Occupational Assessment (S. Haiman & S. Greene). Vocational Assessment (E. Lang). Educational Issues (R. Ostrander & L. Silver). Trauma History (L. Terr). Disabilities History (H. Sachs). CLINICAL OBSERVATION. Observation, Interview, and Mental Status Assessment (OIM): Parent(s) (L. Arnold & P. Jensen). Observation, Interview, and Mental Status Assessment (OIM): Infants and Preschool Children (K. Minde). Observation, Interview, and Mental Status Assessment (OIM): School-Aged Children (R. King). Observation, Interview, and Mental Status Assessment (OIM): Puberty, Adolescents, and Young Adults (S. Weissman & C. Sylvester). Observation, Interview, and Mental Status Assessment (OIM): Family Unit and Subunits (A. Josephson & F. Moncher). The Home Visit (E. Messinger). The School Visit (M. Gordon). Observation, Interview, and Mental Status Assessment (OIM): Unwilling or Resistant (M. Blotcky). Observation, Interview, and Mental Status Assessment (ODM): Culturally Different from Clincian (S. Silverman & J. McDermott). Observation, Interview, and Mental Status Assessment (OIM): Possibly Abused (S. Kaplan). Observation, Interview, and Mental Status Assessment (OIM): Possibly Substance Abusing (J. Gould & S. Jaffe). Observation, Interview, and Mental Status Assessment (OIM): Slow Learning (L. Silver & R. Ostrander). Observation, Interview, and Mental Status Assessment (OIM): Physically ILL (L. Cahen & M. Jellinek). Observation, Interview, and Mental Status Assessment (OIM): Traumatized (L. Terr). Observation, Interview, and Mental Status Assessment (OIM): Violent (E. Pittel). Observation, Interview, and Mental Status Assessment (OIM): Disabled (H. Sachs). Observation, Interview, and Mental Status Assessment (OIM): Competence to Testify (K. Saywitz). Observation, Interview, and Mental Status Assessment (OIM): Competence for Independent Decision Making (P. Ash, et al.). Observation, Interview, and Mental Status Assessment (OIM): Pregnant Adolescent and Teen Parent (L. Ware). Observation, Interview, and Mental Status Assessment (OIM): Adopted (A. Sorosky & B. Sorosky). Observation, Interview, and Mental Status Assessment (OIM): Single-Parent Homes (J. Larrieu & C. Zeanah). Observation, Interview, and Mental Status Assessment (OIM): Divorce (N. Kalter). Observation, Interview, and Mental Status Assessment (OIM): Homosexual (R. Pleak & D. Anderson). Observation, Interview, and Mental Status Assessment (OIM): Cult Involvement (L. West). Physical Examination (J. McConville & B. McConville). Neurological Examination (J. Bregman). Behavioral Assessment (D. Goldston & K. Kirkhart). Psychodynamic Assessment (D. Berland). Rating Scales (J. Goldman & J. Rodrigue). Psychological Testing (J. Rodrigue & J. Goldman). Structured Interviews (J. Young, et al.). Laboratory Testing (J. Levitt & J. McCracken). Genetic Studies (L. Lotspeich). Speech, Language, and Hearing (C. Baltaxe). Brian Imaging (M. Ernst & L. Hertz-Pannier). Electrophysicological Studies (S. Pliszka). Computers and Assessment (M. Huang & N. Alessi). CONCLUDING THE ASSESSMENT PROCESS. Clincial Formulation (B. Nurcombe). Clinical Decision Making (B. Nurcombe). Intervention Strategy Planning (B. Nurcombe). Interpretive Interview with Children and Adolescents and their Parent(s) (L. Arnold & P. Jensen). Report Preparation (B. Nurcombe). Epilogue: The Paths to the Bright Future of Clinical Child/Adolescent Psychiatry (CAP) (S. Harrison). Indexes.
£386.60
John Wiley & Sons Inc Buprenorphine
Book SynopsisBuprenorphine: Combatting Drug Abuse with a Unique Opioid Editors: Alan Cowan and John W. Lewis Scientists involved in the study of opioid pharmacology and drug abuse have long included among their goals the development of effective analgesics with reduced potential for abuse and dependence, and the development of effective pharmacological agents for the treatment of opioid abuse and dependence. Buprenorphine appears to have made an important scientific and clinical contribution on both of these fronts. In this timely volume, international experts describe the unusual chemical and biological characteristics which make this agent unique, from the opiate receptor, through animal pharmacology, to clinical uses, culminating in a discussion of the use of buprenorphine as a medication in the treatment of opioid abuse. Buprenorphine holds great promise as a significant addition to the therapeutic menu available to drug abuse therapists. Buprenorphine: CombaTable of ContentsPartial table of contents: CHEMISTRY. Buprenorphine-Medicinal Chemistry (J. Lewis). PRECLINICAL PHARMACOLOGY. Update on the General Pharmacology of Buprenorphine (A. Cowan). ASSAY, METABOLISM, AND PHARMACOKINETICS. Analysis (R. Moore). CLINICAL PHARMACOLOGY AND EVALUATION. Buprenorphine in Psychiatric Disorders (D. Nutt, et al.). STUDIES RELATING TO TREATMENT OF SUBSTANCE ABUSE. Detoxification and Induction Onto Naltrexone (M. Rosen & T. Kosten). PERSPECTIVE. Buprenorphine: What Interests the National Institute on Drug Abuse? (D. Segal & C. Schuster). Index.
£229.85
John Wiley & Sons Inc Biomedical Mass Transport and Chemical Reaction
Book Synopsis* Presents complex material in an easy to understand progression of ideas. * Illustrates principles by example problems taken from physiology and medicine or design problems involving biomedical devices.Table of ContentsPreface xvi Guidance to Instructors xvii Methods for Solving Model Equations xix Acknowledgments xx About the Companion Website xxi Part I Introduction 1 1 Biological Structure and Function 3 1.1 Cell Energy Related to Whole-Body Function 4 1.2 Tissue and Organ Systems 8 1.3 Cell Structure and Energy Metabolism 16 2 Modeling Concepts for Biological Mass Transport 21 2.1 Representation of Biological Media 21 2.2 Mechanisms of Mass Transport 25 2.3 Formulation of Material Balances 30 2.4 Spatially Lumped and Distributed Models 32 References 39 Part II Thermodynamics of Biomedical Processes 41 3 Basics of Equilibrium Thermodynamics 43 3.1 Thermodynamic Systems and States 43 3.2 Heat, Work, and the First Law 44 3.3 Enthalpy and Heat Effects 45 3.4 Entropy and the Second Law 46 3.5 Gibbs Free Energy and Equilibrium 46 3.6 Properties of the Chemical Potential 51 References 53 4 Interfacial and Membrane Equilibria 54 4.1 Equilibrium Criterion 54 4.2 Interfacial Equilibria 56 4.3 Membrane Equilibria 62 4.4 Electrical Double Layer 71 References 75 5 Chemical Reaction Equilibrium 76 5.1 Equilibrium Criterion 76 5.2 Equilibrium Coefficients 78 5.3 Acid Dissociation 80 5.4 Ligand–Receptor Binding 83 5.5 Equilibrium Models of Blood Gas Content 90 References 101 Part III Fundamentals of Rate Processes 103 6 Nonequilibrium Thermodynamics and Transport Rates 105 6.1 Transport Velocities and Fluxes 105 6.2 Stefan–Maxwell Equation 109 6.3 Diffusion of Uncharged Substances 111 6.4 Diffusion of Electrolytes 116 6.5 Transport across Membranes 117 References 123 7 Mechanisms and Models of Diffusion 124 7.1 Transport Rates in Homogeneous Materials 125 7.2 Diffusion Coefficients in Gases 125 7.3 Diffusion Coefficients in Liquids 128 7.4 Transport in Porous Media Models of Tissue 134 7.5 Transport in Suspension Models of Tissue 144 References 151 8 Chemical Reaction Rates 152 8.1 General Kinetic Models 152 8.2 Basis of Reaction Rate Equations 154 8.3 Multi-Step Reactions 158 8.4 Ligand–Receptor Kinetics 161 8.5 Enzyme Kinetics 166 8.6 Urea Cycle as a Reaction Network 173 References 178 Part IV Transport Models in Fluids and Membranes 179 9 Unidirectional Transport 181 9.1 Unidirectional Transport Equations 181 9.2 Steady-State Diffusion 186 9.3 Diffusion with Parallel Convection 191 9.4 Diffusion with Chemical Reaction 194 9.5 Unsteady-State Diffusion 201 References 203 10 Membrane Transport I: Convection and Diffusion Processes 204 10.1 Ordinary Diffusion 204 10.2 Diffusion with Parallel Convection 211 10.3 Cell Membrane Channels 216 References 223 11 Membrane Transport II: Carrier-Mediated Processes 224 11.1 Facilitated Transport of a Single Substance 224 11.2 Cotransport of Two Substrates 227 11.3 Simulation of Tracer Experiments 230 11.4 Primary Active Transport 237 11.5 Electrical Effects on Ion Transport 242 References 244 12 Mass Transfer Coefficients and Chemical Separation Devices 245 12.1 Transport Through a Single Phase 245 12.2 Transport Through Multiple Phases 256 12.3 Design and Performance of Separation Devices 265 References 279 Part V Multidimensional Processes of Molecules and Cells 281 13 Fluid Mechanics I: Basic Concepts 283 13.2 Mechanical Properties and Rheology of Fluids 289 13.3 Model Formulation and Scaling of Fluid Flow 293 13.4 Steady Flow Through A Tube 299 References 306 14 Fluid Mechanics II: Complex Flows 307 14.1 Boundary Layer Flows 307 14.2 Creeping Flow Through a Leaky Tube 319 14.3 Periodic Flow Along a Tube 323 Reference 329 15 Mass Transport I: Basic Concepts and Nonreacting Systems 330 15.1 Three-Dimensional Mass Balances 330 15.2 Special Cases 332 15.3 One-Dimensional Transport Equations 334 15.4 Model Formulation and Scaling of Mass Transport 339 15.5 Diffusion and Convection in Nonreacting Systems 344 References 357 16 Mass Transport II: Chemical Reacting Systems 358 16.1 Single-Phase Processes 358 16.2 Multiphase Processes 368 16.3 Processes with Interfacial Reaction 380 References 387 17 Cell Population Dynamics 388 17.1 Cell Number Balances 388 17.2 Cell Transport and Fate Processes 389 17.3 Single Cell Population Dynamics 394 17.4 Multiple Cell Population Dynamics 399 Reference 409 Part VI Compartmental Modeling 411 18 Compartment Models I: Basic Concepts and Tracer Analysis 413 18.1 Compartmental Modeling Concepts 413 18.2 Multiple-Compartment Models 421 18.3 Nonideal Inputs and Moment Analysis 430 Reference 438 19 Compartment Models II: Analysis of Physiological Systems 439 19.1 Open-Loop Models 439 19.1.1 Multipool Model of Glucose Metabolism 439 19.2 Models with Feedback and Recirculation 452 References 466 Part VII Advanced Biomedical Applications 467 20 Therapies for Tissue and Organ Dysfunction 469 20.1 Dynamics of Urea Clearance in a Patient During Hemodialysis 469 20.2 Hemodialyzer Performance with Varying Filtration 474 20.3 Gas Exchange in an Intravascular Lung Device 480 20.4 Separation of Blood Components by Apheresis 486 20.5 Epidermal Regeneration in Tissue-Engineered Skin 490 References 497 21 Drug Release, Delivery, and Distribution 498 21.1 Drug Release From an Agglomerated Tablet 498 21.2 Drug Release From an Osmotic Pump Device 504 21.3 Intestinal Drug Transport 509 21.4 Drug Distribution in Ablated Tissues 515 21.5 Intracranial Drug Delivery and Distribution 520 21.6 Whole-Body Methotrexate Distribution 526 References 534 22 Diagnostics and Sensing 535 22.1 Chemical Monitoring of Tissue by Microdialysis 535 22.2 Dual-Electrode Measurement of Blood Flow and Oxygen 541 22.3 Detection of Ethanol in Blood from Exhaled Gas 546 22.4 Oxygen Uptake and Utilization in Exercising Muscle 552 22.5 Tracer Analysis with Pet Imaging 562 22.6 Cancer Cell Migration with Cell–Cell Interaction 569 References 576 Appendix A Units and Property Data 577 A.1 American National Standard for SI Units 577 A.2 Definitions of Concentration 579 A.3 Thermodynamic Properties 580 A.4 Transport Properties 583 References 586 Appendix B Representing Transport Processes in Complex Systems 587 B.1 Vector and Tensor Operations 587 B.2 Nonequilibrium Thermodynamics 592 B.3 Spatially Averaged Balances for Heterogeneous Tissue 596 B.4 Tables for Fluid Motion in Common Coordinate Systems 602 References 604 Appendix C Mathematical Methods 605 C.1 Dimensionless Forms and Scaling 605 C.2 Inversion of Square Matrices 608 C.3 Initial-value Problems 609 C.4 Laplace Transforms 613 C.5 Alternative Representation of a Point Source 614 C.6 Similarity Transform of a Partial Differential Equation 615 Nomenclature 619 Index 624
£124.40
John Wiley and Sons Ltd Cancer Epigenetics
Book SynopsisCancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.Trade Review“In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.” (ChemMedChem, 1 July 2013)Table of ContentsContributors. Preface. SECTION I: EPIGENETICS AND CELL CYCLE. 1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso). SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION. 2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano). 3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn). 4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli). SECTION III: EPIGENETICS AND GENE TRANSCRIPTION. 5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini-Kerth). 6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano). SECTION IV: EPIGENETICS AND CANCER. 7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell). 8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa). 9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota). 10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio). SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY. 11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano). 12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr). 13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano). 14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio). Index.
£135.80
John Wiley & Sons Inc Chronopharmaceutics
Book SynopsisChronopharmaceutics covers the fundamentals of the various aspects of chronopharmaceutics in the fields of chronobiology, chronogenetics, chronophysiology, chronopathology, chronopharmacology, chronotherapeutics, chronotoxicology and chronobiotics, and chronopharmaceutical drug delivery research.Table of ContentsPREFACE. ACKNOWLEDGMENTS. CONTRIBUTORS. ABBREVATION LIST. INTRODUCTION: TIME, DIAGNOSTICS, AND THERAPEUTICS—BEYOND CIRCADIAN MARKER RHYTHM-GUIDED TREATMENT (Franz Halberg, Germaine Corne lissen, and Othild Schwartzkopff). 1 OVERVIEW OF CHRONOPHARMACEUTICS (Bi-Botti C. Youan). 2 CHRONOGENETICS (Franck Delaunay). 3 CHRONOPHARMACOKINETICS (Bernard Bruguerolle). 4 CHEMICAL OSCILLATOR SYSTEMS FOR CHRONOTHERAPY (Steven A. Giannos). 5 DIFFUCAPS TECHNOLOGY FOR CONTROLLED RELEASE DRUG DELIVERY (Gopi Venkatesh). 6 CHRONOTOPICt TECHNOLOGY (M. E. Sangalli, A. Maroni, L. Zema, M. Cerea, and A. Gazzaniga). 7 CHRONOTHERAPY USING EGALET TECHNOLOGY (Daniel Bar-Shalom, Clive G. Wilson, and Neena Washington). 8 CHRONSETt: AN OROS DELIVERY SYSTEM FOR CHRONOTHERAPY (Liang C. Dong, Crystal Pollock-Dove, and Patrick S.L. Wong). 9 CONTROLLED RELEASE MICROCHIPS (Karen Daniel, Hong Linh Ho Duc, Michael Cima, and Robert Langer). 10 IMPLICATIONS AND APPLICATIONS OF CIRCADIAN SUSCEPTIBILITY RHYTHMS: CHRONOMICS AND ANESTHESIA (Franz Halberg, Germaine Corne´ lissen, and Othild Schwartzkopff). 11 TREATMENT WITH OPEN EYES: MARKERS-GUIDED CHRONOTHERANOSTICS (Germaine Corne lissen, and Franz Halberg). INDEX.
£115.85
John Wiley and Sons Ltd Cosmesis of the Mouth Face and Jaws
Book SynopsisCosmesis of the Mouth, Face and Jaws provides a unique, whole-face approach to cosmetic procedures, focusing on oral, facial and gnathic components.Table of ContentsContributors Preface Acknowledgment Chapter 1 What Is Beauty? Steven A. Guttenberg DDS, MD Chapter 2 Smile Design and Veneers Peter Rinaldi DDS Chapter 3 Optimal Use of Dental Implants for Cosmesis: Creating Aesthetic Outcomes with Dental Implant Restorations Neil L. Starr DDS Chapter 4 Aesthetic Decisions in Adult Orthodontics Wayne Hickory DMD, MDS and Rohit Sachdeva BDS, MDS Chapter 5 Optimizing Dental Implant Aesthetics Joel Rosenlicht DMD and James Ward DMD Chapter 6 Lip and Perioral Cosmetic Surgery Jon Perenack MD, DDS Chapter 7 Injectable Fillers for Cosmetic Facial Enhancement Bruce N. Epker DDS, MSD, PhD Chapter 8 Aesthetic Facial Implants William J. Binder MD, FACS Chapter 9 Neuromuscular Blockers Paul G. Ruff IV MD, FACS Chapter 10 Skin Rejuvenation Suzan Obagi MD and Shauna Kranendonk MD Chapter 11 Scar Revision Saif S. Al-Bustani MD, DMD and R. Bryan Bell MD, DDS, FACS Chapter 12 Liposuction Douglas M. Monasabian MD, DMD, FACS Chapter 13 Cosmetic Blepharoplasty Lauren Gavaris MD and Paul Gavaris MD Chapter 14 Brow Lifting Matthew R. Hlavacek MD, DDS and Steven J. Prstojevich MD, DDS, FACS Chapter 15 Cosmetic Rhinoplasty Leonard Spector DDS Chapter 16 Otoplasty: Surgical Correction of the Prominent Ear Todd G. Owsley DDS, MD Chapter 17 Rhytidoplasty Robert A. Strauss DDS, MD and Kevin P. Bond DDS Chapter 18 Short-Scar Face-Lift Options Steven B. Hopping MD, FACS Chapter 19 Aesthetic Benefits of Orthognathic Surgery Charles Dennis Hasse DDS, MD Chapter 20 Minimally Invasive Orthognathic and Condylar Surgery Carl Bouchard DMD, MSc, FRCD(C), Matthew Lawler BS, Leonard B. Kaban DMD, MD and Maria J. Troulis DMD, MSc Chapter 21 Hair Transplantation Marc R. Avram MD and Nicole E. Rogers MD Index
£189.00
John Wiley and Sons Ltd Risk Assessment and Oral Diagnostics in Clinical
Book SynopsisRisk Assessment and Oral Diagnostics in Clinical Dentistry aims to enable the dental practitioner to comfortably and capably assess when medical conditions may impact dental care and diagnose oral conditions using routine testing modalities.Trade Review“This book provides generalists at any level a good overview of common oral diseases. Importantly, it provides a useful metric to approaching medically compromised individuals. There are a few other books that may provide a more in-depth review of oral medicine and management of the medically complex patient in dentistry, such as Oral Medicine and Medically Complex Patients, 6th edition, Lockhart (Wiley-Blackwell, 2013), which treats the topic in more depth.” (Doody’s, 3 January 2014)Table of ContentsAuthors vii Preface ix Acknowledgements xi PART A: GUIDELINES FOR RISK ASSESSMENT OF SYSTEMIC CONDITIONS THAT MAY COMPLICATE OR BE COMPLICATED BY DENTAL TREATMENT 1 1 Basics of the Health History, Physical Examination, and Clinical Investigations 3 2 Basic Tests and Evaluation Methods of Systemic Health 27 3 Potential for Bleeding 47 4 Potential for Infection 63 5 Potential for Poor Wound Healing 77 PART B: GUIDELINES FOR DIAGNOSIS OF OROFACIAL CONDITIONS 89 6 Dental Caries and Periodontal Conditions 91 7 Oral Infection 107 8 Salivary Conditions 123 9 Oral Neoplastic Disease 139 10 Oral Complications Associated with Cancer Therapy 151 11 Oral Manifestations of Autoimmune, Immune-Mediated, and Allergic Disorders 171 12 Orofacial Pain Conditions 193 Appendix: Top 10 List of Non-odontogenic Oral Conditions 211 Index 215
£64.55
John Wiley and Sons Ltd Imaging Musculoskeletal Trauma
Book SynopsisOffers a well-designed approach to imaging musculoskeletal trauma Medical imaging plays an important role in identifying fractures and helping the patient return to regular activities as soon as possible. But in order to identify the fracture, and describe all the relevant associated injuries, the radiologist first needs to understand normal anatomy and the mechanisms of fractures. Imaging Musculoskeletal Trauma reviews common fracture and dislocation mechanisms and provides up-to-date guidelines on the use and interpretation of imaging tests. Designed for use by professionals in radiology, orthopedics, emergency medicine, and sports medicine, this book offers a concise, systematic approach to imaging musculoskeletal trauma. Replete with easily accessible information, including well-designed tables and lists, the book features radiology report checklists for each anatomic site, numerous radiographs and CT and MRI images, simple illustrations for common fracture Trade Review“In summary, Imaging Musculoskeletal Trauma Interpretation and Reporting is a very well-written textbook with comprehensive evaluation of fractures and fracture-dislocations of the axial and appendicular skeleton, with minor limitations. This book can be recommended as a useful guideline in radiologic evaluation and interpretation of musculoskeletal trauma cases for radiology trainees, practicing radiologists, and other clinicians with an interest in musculoskeletal trauma.” (Journal of Magnetic Resonance Imaging, 25 February 2014)Table of ContentsPreface vi List of Contributors vii 1 Essential Concepts in Imaging Musculoskeletal Trauma 1 Andrea Donovan 2 Pediatric Skeletal Trauma 31 Elka Miller, Jorge Davila, Carmen Rotaru, and Khaldoun Koujok 3 Spine 61 Chris Heyn and Rafael Glikstein 4 Shoulder and Proximal Humerus 109 Andrea Donovan 5 Elbow and Forearm 141 Philip Hodnett and Andrea Donovan 6 Wrist and Hand 171 Deep Chatha 7 Pelvis and Proximal Femur 211 Emad Almusa, Stamatis N. Kantartzis, and Joshua Leeman 8 Knee and Tibia and Fibula Shafts 253 Andrew Lischuk, Edward Smitaman, Kristen Menn, and Andrew Haims 9 Ankle and Foot 289 Adnan Sheikh 10 Fracture Healing and Complications of Fractures 341 Marcos Loreto Sampaio Index 379
£135.80
John Wiley and Sons Ltd Percutaneous Renal Surgery
Book SynopsisPercutaneous renal procedures are highly complex and require a great deal of surgical skill. This book provides urologists, nephrologists and surgeons with the knowledge, confidence and clinical skills required to perform these complex and difficult surgical procedures safely and effectively.Table of ContentsContributor List, vii Preface, xiii About the Companion Website, xiv Section 1: Introduction 1 Percutaneous Renal Access: A Historical Perspective, 3 Simpa S. Salami, Zeph Okeke, and Arthur D. Smith 2 Interventional Imaging and Radiation Safety, 7 Don C. Arnold II, Kirk M. Anderson, and D. Duane Baldwin Section 2: Percutaneous Management of Large Renal Calculi (Percutaneous Nephrolithotomy) 3 Epidemiology of Large Renal Stones and Utilization Patterns of Percutaneous Nephrolithotomy, 23 Stephen Faddegon and Margaret S. Pearle 4 Evolution of Evidence-Based Outcomes for Percutaneous Nephrolithotomy, 31 Kirsten Foell and Kenneth T. Pace 5 Patient Selection and Informed Consent, 46 Nader Fahmy and John Denstedt 6 Instrumentation and Surgical Technique: Percutaneous Access, 59 Naeem Bhojani and James E. Lingeman 7 Instrumentation and Surgical Technique: Tract Dilation and Endoscopes, 64 Michael J. Metcalfe, Ryan Paterson, and Ben Chew 8 Instrumentation and Surgical Technique: Intracorporeal Lithotrites, 74 Abhishek P. Patel and Bodo E. Knudsen 9 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Prone, 84 Mantu Gupta and Doh Yoon Cha 10 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Supine, 95 Arvind Ganpule, Amit Doshi, and Mahesh R. Desai 11 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Prone-Flexed/Lateral, 106 Kirsten Foell and R. John D’A. Honey 12 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Endoscopic Guidance, 116 Farhan Khan, Ross Moskowitz, Joseph Graversen, Michael Ordon, Ralph V. Clayman, and Jaime Landman 13 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Mini-Percutaneous Nephrolithotomy, 126 Gunnar Wendt-Nordahl and Thomas Knoll 14 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Multiple Access, 134 Jessica N. Lange, Patrick W. Mufarrij, and Dean G. Assimos 15 Instrumentation and Surgical Technique: Step-by-Step Percutaneous Nephrolithotomy: Tube or Tubeless Percutaneous Nephrolithotomy, 143 Andreas Neisius, Michael E. Lipkin, and Glenn M. Preminger 16 Instrumentation and Surgical Technique: Postoperative Imaging Following Percutaneous Nephrolithotomy, 152 Aditya Bagrodia and Margaret S. Pearle 17 Instrumentation and Surgical Technique: Step-by-Step Antegrade Ureteric Stenting, 161 Ravi Kulkarni Section 3: Percutaneous Management of Transitional Cell Cancer (Percutaneous Resection of Tumor) 18 Epidemiology of Disease (Upper Tract Transitional Cell Cancer), 175 Matthew R. Hotston, Sunil Mathur, and Francis X. Keeley 19 Evidence-Based Outcomes for Percutaneous Management of Upper Tract Urothelial Carcinoma, 182 Eric R. Taylor and Marshall L. Stoller 20 Patient Selection and Informed Consent, 190 Michael Conlin and Nicholas Tadros 21 Percutaneous Treatment of Upper Tract Urothelial Carcinoma, 196 Steve Dong, Matthew Dunn, and Mihir Desai Section 4: Percutaneous Ablation of Renal Cell Cancer (Thermal and Nonthermal) 22 Epidemiology and Biology of Small Renal Masses, 205 Paul L. Crispen and Steven C. Campbell 23 Evolution of Evidence-based Outcomes for Percutaneous Management, 215 Matthew J. O’Shaughnessy, David A. Leavitt, and J. Kyle Anderson 24 Patient Selection and Informed Consent, 224 Humberto Laydner and Jihad H. Kaouk 25 Instrumentation and Technique: Cryotherapy, 229 Achim Lusch, Jane Cho, Michael A. Liss, Joseph Graversen, and Jaime Landman 26 Instrumentation and Technique: Hyperthermal Ablation: Radiofrequency and Microwave Ablation, 237 Arturo Castro Jr, Lawrence Jenkins, Obi Ekwenna, John Shields, Nelson Salas, and Raymond Leveillee 27 Instrumentation and Technique: High-Intensity Focused Ultrasound, 253 Robert W. Ritchie, Tom Leslie, David Cranston, and Mark Sullivan 28 Instrumentation and Technique: Laser, 262 Ramakrishna Venkatesh, Jason R. Bylund, and Stephen E. Strup 29 Instrumentation and Technique: Irreversible Electroporation, 268 Chad R. Tracy and Jeffrey A. Cadeddu 30 Instrumentation and Techniques in Renal Radiosurgery, 276 Matthew J. Maurice, Gino J. Vricella, and Lee E. Ponsky 31 Instrumentation and Technique: Renal Histotripsy, 281 William W. Roberts Index, 290
£143.95
John Wiley & Sons Inc Nanomaterials in Drug Delivery Imaging and Tissue
Book SynopsisThis comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds. The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the neTrade Review“The volume was written by many scientists working in the new area of nanotechnology. Each chapter has an extensive reference list and there is a short index at the end.” (Optics & Photonics News, 22 November 2013)Table of ContentsPreface xv Part I: Biomedical nanomaterials 1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1 Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5 1.2.1 Generalities on Emulsions 5 1.2.2 Nanoemulsion vs. Microemulsion, a Thermodynamic Definition 6 1.3 Stable Nanoemulsion Formulation 9 1.3.1 Nanoemulsion Production 9 1.3.2 Nanoemulsion Stability Rules 11 1.3.3 Nanoemulsion Formulation Domain 16 1.3.4 Conclusion on the Formulation of Stable Nanoemulsions 21 1.4 Nanoencapsulation in Lipid Nanoparticles 21 1.4.1 Aim ofActive Encapsulation 21 1.4.2 Lipid Complexity and Influence of Their Physical State 23 1.4.3 Amorphous Lipids for a Large Range of Encapsulated Molecules 27 1.4.4 Lipids Viscosity and Release 31 1.4.5 Conclusion on the Use ofAmorphous Lipid Matrices for Control OverActive Encapsulation and Release 34 1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.5.1 Nanoemulsion Biocompatibility 35 1.5.2 Classical TargetingApproach by Chemical Grafting – Example of Tumor Cell Targeting by Crgd Peptide for Cancer Diagnosis and Therapy 38 1.5.3 New ‘No Synthesis Chemistry’Approach – Example of Pal-KTTKS andAsiaticoside Targeting for CosmeticActives Delivery 41 1.5.4 Conclusion on Nanoemulsions Application in Biosciences 46 1.6 General Conclusion 47 References 48 2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61 2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.5.1 Dendrimers 67 2.5.2 Vesicles 68 2.5.3 Micelles 70 2.6 Smart Nanopolymers 71 2.6.1 Temperature and pH Stimuli-responsive Nanopolymers 72 2.6.2 Hydrogels 72 2.6.3 Stimuli Responsive Biomaterials 73 2.6.4 Interpenetrating Polymer Networks 74 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8 Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and S. Kwon 3.1 Introduction 98 3.1.1 What is Nanotoxicity of Nanomaterials? 98 3.2 Historical Review of Carbon Nanotube 99 3.3 Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.3.1 Physical Principles of Carbon Nanotube Surface Science 102 3.4 Motivation – Combining Nanotechnology and Surface Science with Growing Bioapplications 104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.1.6 In Vivo Studies on CNT Toxicity 113 3.1.7 Inflammatory Mechanism of CNT Cytoxicity 114 3.1.8 Characterization and Toxicity of SWCNT and MWCNT Carbon Nanotubes 116 3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120 3.6.1 An In Vivo Model CNT-Induced Inflammatory Response in Alveolar Co-culture System 122 3.6.2 Static Model: 3-Dimensional Tissue Engineered Lung 124 3.6.3 Dynamic Model: Integration of 3D Engineered Tissues into Cyclic Mechanical Strain Device 126 3.6.4 In Vivo MR Microimaging Technique of Rat Skin Exposed to CNT 127 3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II: Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4 Exploiting the Enhanced Permeability and Retention Effect 159 4.5 Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion 165 Acknowledgments 165 References 166 5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2 Common Lung DiseasesAnd Treatment Methods 171 5.2.1 Lung Cancer 171 5.2.2 PulmonaryArterial Hypertension 172 5.2.3 Obstructive Lung Diseases 173 5.3 Types of Nanoparticles (NPs) 173 5.3.1 Liposomes 174 5.3.2 Micelles 176 5.3.3 Dendrimers 177 5.3.4 Polymeric Micro/Nanoparticles 177 5.4 Methods for Pulmonary Delivery 179 5.4.1 Nebulization 179 5.4.2 Metered Dose Inhalation (MDI) 182 5.4.3 Dry Powder Inhalation (DPI) 183 5.4.4 IntratrachealAdministration 183 5.5 Targeting Mechanisms 184 5.5.1 Passive Targeting 184 5.5.2 Active Targeting 185 5.5.3 Cellular Uptake Mechanisms 188 5.6 TherapeuticAgents Used for Delivery 188 5.6.1 ChemotherapeuticAgents 188 5.6.2 Bioactive Molecules 190 5.6.3 Combinational Therapy 190 5.7 Applications 191 5.7.1 Imaging/DiagnosticApplications 191 5.7.2 TherapeuticApplications 193 5.7.3 Lung Remodeling and Regeneration 194 5.8 Design Considerations of NPs 195 5.8.1 Half-life of NPs 195 5.8.2 Drug Release Mechanisms 195 5.8.3 Clearance Mechanisms in the Lung 196 5.9 Current Challenges and Future Outlook 197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1 Introduction 200 6.2 Vectors for Gene Delivery 202 6.2.1 Viral Vectors 203 6.2.2 Non-viral Vectors 203 6.2.3 Calcium Phosphate Vectors 205 6.3 Modulation of Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4 Calcium Phosphate Carriers for Drug Delivery Systems 219 6.4.1 Antibiotics Delivery 219 6.4.2 Growth Factor Delivery 221 6.5 Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221 Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems Based on Organics Modified 7.2.1 MSNs-based Drug Delivery Systems Controlled by Physical Stimuli 238 7.2.2 MSNs-based Drug Delivery Systems Controlled by Chemical Stimuli 246 7.3 Conclusions 258 References 259 Part III: Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou 8.1 Introduction 264 8.2 Mechanisms of Response 268 8.2.1 Reception of an External Signal 268 8.2.2 Volume Phase Transition of the Hybrid Nanogels 275 8.2.4 Regulated Drug Delivery 282 8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285 8.3.1 Synthesis of the Hybrid Nanogels from Pre-synthesized Polymer Nanogels 285 8.3.2 Synthesis of the Hybrid Nanogels from Pre-synthesized Inorganic NPs 289 8.3.3 Synthesis of the Hybrid Nanogels by a Heterogeneous Polymerization Method 292 8.4 Applications 293 8.4.1 Responsive Polymer-inorganic Hybrid Nanogels in Optical Sensing 293 8.4.2 Responsive Polymer-inorganic Hybrid Nanogels in Diagnostic Imaging 299 8.4.3 Responsive Polymer-inorganic Hybrid Nanogels in Drug Delivery 301 References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis 315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from Polymeric Micelles 319 9.2.1 Polymeric Micelles with Physical Drug Entrapment 319 9.2.2 Polymeric Micelles with Drug Conjugation 321 9.2.3 Polymeric Micelles Formed by Temperature-Induced Phase Transition 323 9.3 Phospholipid-based Core/Shell Nanoparticles 325 9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References 331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339 Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash 10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3 Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.3.1 Genes (siRNA/ANS/DNA) 344 10.3.2 Drugs and Pharmaceutics 345 10.4 PotentialApplications of Dendrimer in Nanomedicine 347 10.4.1 Delivery of Chemotherapeutics 347 10.4.2 Delivery of Biomolecules 348 10.4.3 Imaging 350 10.5 Conclusion 353 Acknowledgements 355 Indexing words 355 References 355 11 Theranostic Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J. Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional Nanoparticles for Noninvasive 11.2.1 Radiolabeled Nanoparticles 366 11.2.2 Fluorescence Imaging of Biodistribution 367 11.2.3 Multimodal Radiolabel and Fluorescence Imaging of Biodistribution 368 11.2.4 MRI Imaging of Biodistribution 369 11.2.5 Multimodal MRI and Fluorescence Imaging of Biodistribution 371 11.2.6 Multimodal Optical and CT Imaging of Biodistribution 372 11.2.7 Pharmacokinetics and Pharmacodynamics of Theranostics vs Diagnostics 373 11.3 Multifunctional Nanoparticles for Monitoring Drug Release 375 11.3.1 MRI imaging of Drug Release 375 11.3.2 Fluorescent Imaging of Drug Release 379 11.4 Theranostics to Image Therapeutic Response 380 11.5 Conclusion and Future Directions 382 Acknowledgement 383 References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers in Function Generating Substitute and Organ Transplants 389 S.K. Shukla 12.1 Introduction 389 12.2 Important Nanopolymers 391 12.2.1 Hydrogels 393 12.2.2 Bioceramics 394 12.2.3 Bioelastomers 395 12.2.4 Chitosan and Derivatives 396 12.2.5 Gelatine 396 12.3 MedicalApplications 397 12.3.1 Tissue Engineering for Function Generating 398 12.3.2 Tissue Engineering inArtificial Heart 400 12.3.3 Tissue Engineering in Nervous System 401 12.3.4 Bone Transplants 404 12.3.5 Kidney and Membrane Transplants 406 12.3.6 Miscellaneous 409 Acknowledgement 411 References 411 13 Electrospun Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber Scaffolds Fabrication Techniques 419 13.2.1 Self-Assembly 419 13.2.2 Phase Separation 421 13.2.3 Electrospinning 422 13.3 Parameters of Electrospinning Process 424 13.3.1 Viscosity or Concentration of the Polymeric Solution 424 13.3.2 Conductivity and the Charge Density 425 13.3.3 Molecular Weight of Polymer 425 13.3.4 Flow Rate 425 13.3.5 Distance from Tip to Collector 425 13.3.6 VoltageApplied 426 13.3.7 Environmental Factors 426 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture 426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis D’Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and Structure of Magnetic Nanoparticles 443 14.5 Stability and Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic Nanoparticles 453 14.7.1 Magnetofection 455 14.7.2 Cell-patterning 458 14.7.3 Magnetic Force-induced Tissue Fabrication 461 14.8 Challenges and Future Prospects 473 Acknowledgement 474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485 Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.1.1 Tissue Engineering 487 15.1.2 Scaffold Fabrication Technology 488 15.2 Core-sheath Nanofiber Technology 489 15.2.1 Co-axial Electrospinning 491 15.2.2 Emulsion Electrospinning 501 15.2.3 Melt Co-axial Electrospinning 503 15.3Application of Core-sheath Nanofibers 504 15.3.1 Delivery of Bioactive Molecules 504 15.3.2 Tissue Engineering 513 15.4 Conclusions 519 References 519
£193.75
John Wiley & Sons Inc Integrated Biomaterials in Tissue Engineering
Book SynopsisThis book acts as a self-contained resource for understanding the current technological advancement of biomaterials towards tissue engineering applications.Table of ContentsPreface xiii 1. Protocols for Biomaterial Scaffold Fabrication 1 Azadeh Seidi and Murugan Ramalingam 1.1 Introduction 1 1.2 Scaffolding Materials 4 1.3 Techniques for Biomaterial Scaffolds Fabrication 7 1.4 Summary 19 Acknowledgements 20 2. Ceramic Scaffolds, Current Issues and Future Trends 25 Seyed-Iman Roohani-Esfahani S. I. and Hala Zreiqat H. 2.1 Introduction 25 2.2 Essential Properties and Current Problems of Ceramic Scaffolds 27 2.3 Approaches to Overcome Ceramic Scaffolds Issues for the Next Generation of Scaffolds 30 2.4 Silk – a Bioactive Material 35 Acknowledgements 36 References 36 3. Preparation of Porous Scaffolds from Ice Particulate Templates for Tissue Engineering 47 Guoping Chen and Naoki Kawazoe 3.1 Introduction 48 3.2 Preparation of Porous Scaffolds Using Ice Particulates as Porogens 48 3.3 Preparation of Funnel-like Porous Scaffolds Using Embossed Ice Particulate Templates 51 3.4 Application of Funnel-like Porous Scaffolds in Three-dimensional Cell Culture 56 3.5 Application of Funnel-like Collagen Sponges in Cartilage Tissue Engineering 57 3.6 Summary 60 References 60 4. Fabrication of Tissue Engineering Scaffolds 63 Naznin Sultana and Min Wang 4.1 Introduction 64 4.2 Materials for Tissue Engineering Scaffolds 65 4.3 Fabrication Techniques for Tissue Engineering Scaffolds 68 4.4 Fabrication of Pure Polymer Scaffolds via Emulsion Freezing/Freeze-drying and Characteristics of the Scaffolds 70 4.5 Fabrication of Polymer Blend Scaffolds via Emulsion Freezing/Freeze-drying and Characteristics of the Scaffolds 78 4.6 Fabrication of Nanocomposite Scaffolds via Emulsion Freezing/Freeze-drying and Characteristics of the Scaffolds 80 4.7 Surface Modification for PHBV-based Scaffolds 85 4.8 Concluding Remarks 87 Acknowledgments 87 References 88 5. Electrospun Nanofiber and Stem Cells in Tissue Engineering 91 Susan Liao, Seeram Ramakrishna and Murugan Ramalingam 5.1 Introduction 92 5.2 Biodegradable Materials for Tissue Engineering 93 5.3 Nanofibrous Scaffolds 97 5.4 Stem Cells: A Potential Tool for Tissue Engineering 109 5.5 Prospects 114 Acknowledgement 116 References 116 6. Materials at the Interface Tissue-implant 121 Antonio Peramo 6.1 Introduction 122 6.2 Description of the Tissue-device Interface 123 6.3 Expected Function of the Materials at the Interface and their Evaluation and Selection 125 6.4 Experimental Techniques for the Tissue-implant Interface 132 6.5 Conclusion 135 References 135 7. Mesenchymal Stem Cells in Tissue Regeneration 139 Kalpana S. Katti, Avinash A. Ambre, and Dinesh R. Katti 7.1 Introduction 139 7.2 Mesenchymal stem cells (MSCs) 144 7.3 Understanding the Mesenchymal Stem Cells (MSCs) 149 7.4 Mesenchymal Stem Cell (MSC) Culture 152 7.5 Characterization of MSCs 155 7.6 MSCs in Bone Remodeling, Fracture Repair and their Use in Bone Tissue Engineering Applications 158 7.7 Influence of External Stimuli on MSC Behavior 159 7.8 Perspectives on Future of hMSCs in Tissue Engineering 161 References 162 8. Endochondral Bone Tissue Engineering 167 Sanne K. Both, Fang Yang, and John A. Jansen 8.1 Introduction 167 8.2 Tissue Engineering and Stem Cells 171 8.3 Scaffolds 175 8.4 Summary 181 References 182 9. Principles, Applications, and Technology of Craniofacial Bone Engineering 185 Mona K. Marei, Mohamed A. Alkhodary, Rania M. Elbackly, Samer H. Zaky, Admed M. Eweida, Muhammad A. Gad, Maglaa Abdel-Wahed and Yasser M. Kahad 9.1 Introduction 186 9.2 Road Map for the Application of Tissue Engineering and Regenerative Medicine for Craniofacial Bone Regeneration 197 9.3 Stem Cell-based Craniofacial Bone Engineering 201 9.4 Biomaterial-based Therapy in Craniofacial Bone Engineering 208 9.5 Principles of Imaging in Craniofacial Bone Regeneration 214 9.6 Current Clinical Application and Future Direction in the Field of Craniofacial Bone Engineering 222 9.7 Future Prospects 227 9.8 Economics and Marketing 227 9.9 Conclusions 228 References 228 10. Functionally-Graded Biomimetic Vascular Grafts for Enhanced Tissue Regeneration and Bio-integration 237 Vinoy Thomas and Yogesh K. Vohra 10.1 Introduction 238 10.2 Approaches in Vascular Tissue Engineering 239 10.3 Nanostructured Scaffolds for Vascular Tissue Engineering 241 10.4 Functionally-Graded Tubular Scaffolds 249 10.5 Summary and Future Outlook 268 Acknowledgements 269 List of Abbreviations Used 270 References 271 11. Vascular Endothelial Growth Factors in Tissue Engineering: Challenges and Prospects for Therapeutic Angiogenesis 277 Ekaterina S. Lifirsu, Murugan Ramalingam, and Ziyad S. Haidar 11.1 Introduction 278 11.2 VEGF and Angiogenesis 278 11.3 VEGF Family 279 11.4 VEGF Therapy 281 11.5 VEGF Delivery Systems 282 11.6 Soft versus hard Tissues 284 11.7 Concluding Remarks 289 References 292
£154.80
John Wiley and Sons Ltd Pediatric Drug Development
Book SynopsisMost medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions.Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations.This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globaTable of ContentsList of Contributors Preface Part I: PAST, PRESENT, AND FUTURE OF PEDIATRIC DRUG DEVELOPMENT 1 Pediatric Drug Development and Therapeutics: Continued Progress for Better Drugs for Children Andrew E. Mulberg, Lisa Mathis, Julia Dunne and Dianne Murphy 2 History of Children and the Development of Regulations at the FDA Robert M. Ward and Steven Hirschfeld 3 Population Dynamics, Demographics, and Disease Burden of Infants and Children Across the World Ashley Malins and Christopher-Paul Milne 4 Pharmaceutical Economics and Market Access for Pediatric Medications Christopher-Paul Milne and Ashley Malins 5 The Global Pediatric Market and Drivers of Pediatric Drug Development E. Michael D. Scott 6 Industry Benchmarks in Pediatric Clinical Trials Carolyn A. Campen and Cindy Levy-Petelinkar Part II: ETHICAL UNDERPINNINGS 7 Ethical and practical considerations in conducting neonatal research Michelle Roth-Cline and Robert M. Nelson 8 Ethical considerations in conducting pediatric research Michelle Roth-Cline and Robert M. Nelson 9 The Consent and Assent Process in Pediatric Clinical Trials M. Renee Simar Part III: REGULATORY GUIDELINES FOR PEDIATRIC DRUG DEVELOPMENT 10 A Sponsor’s Perspective of US Regulations Samuel Maldonado 11 FDA experience of extrapolation of efficacy to the pediatric population from adult and other data Julia Dunne, William J. Rodriguez and Dianne Murphy 12 Accelerated Approval and other regulatory approaches to the development of drugs for serious or life-threatening diseases in pediatrics Therese Cvetkovich 13 Rare Diseases and Orphan Drugs Anne R. Pariser and Lynne P. Yao 14 European Perspective Agnès Saint-Raymond 15 Five years of pediatric legislation in the European Union Agnès Saint-Raymond and Ralf Herold 16 Japanese Perspective Hidefumi Nakamura and Shunsuke Ono 17 Pediatric Device Development in the United States Priya Venkataraman-Rao and Joy Samuels-Reid Part IV: PRECLINICAL SAFETY ASSESSMENT 18 Introduction and Overview Timothy P. Coogan and Melissa S. Tassinari 19 Juvenile Animal Toxicity Assessments: Decision Strategies and Study Design Luc M. De Schaepdrijver, Graham P. Bailey, Timothy P. Coogan and Jennifer L. Ingram-Ross 20 Absorption, Distribution, Metabolism and Excretion (ADME) and Pharmacokinetic Assessments in Juvenile Animals Loeckie L. de Zwart, Johan G. Monbaliu and Pieter P. Annaert 21 A Global Regulatory Perspective Karen Davis-Bruno, Jacqueline Carleer, Beatriz Silva Lima and Melissa S. Tassinari 22 Disease specific models to enhance Pediatric drug development Niraj R. Mehta and Sruthi King Part V: PHARMACOLOGICAL PRINCIPLES IN PEDIATRIC DRUG DEVELOPMENT 23 Pediatric Clinical Pharmacology in Regulatory and Drug Development Sciences: Lessons learned and the Path Forward Gilbert J. Burckart and Jeremiah Momper 24 Development and Clinical Trial Design Kathleen A. Neville, Ralph E. Kauffman, and Susan M. Abdel-Rahman 25 Developmental Hepatic Pharmacology in Pediatrics Martin Otto Behm 26 Applications of Population Pharmacokinetics for Pediatric Drug Development Jeremiah Momper, Gilbert J. Burckart and Pravin Jadhav 27 Applications of Pharmacogenomics to Pediatric Drug Development Gilbert J. Burckart, Dionna Green and Padmaja Mummaneni 28 Pharmacometrics Applications to Pediatric Trials Devin Pastoor, Mallika Lala, Jogarao V.S. Gobburu Part VI: CLINICAL TRIAL OPERATIONS 29 Brain and Central Nervous System Development: Physiological Considerations for Assessment of Long-Term Safety Kachikwu Illoh 30 Cognitive Development Considerations for Long-Term Safety Exposures in Children Mary Pipan, Paul Wang, and Rebecca Thompson-Penna 31 Cardiovascular and QTc Issues Bert Suys and Luc Dekie 32 Pediatric bone and adult bone – physiological differences Francisco A. Sylvester and Erica L. Wynn 33 Renal Function Issues Katia Boven 34 Growth and Physical Development Alisha J. Rovner and Babette S. Zemel 35 Development of Drugs for Pediatric Cancers Kristen M. Snyder, Martha Donoghue, Whitney S. Helms, and Gregory Reaman Part VII: CLINICAL TRIAL OPERATIONS AND GOOD CLINICAL TRIALS 36 Recruitment and Retention in Pediatric Clinical Trials: Focus on Networks in the US and EU Rosalind L. Smyth, Geetinder Kaur, Daniel Benjamin Jr, and Matthew Laughon 37 Recruitment and Retention of Minority populations in Clinical Trials Benjamin Ortiz and Sergio Guerrero 38 Conducting Clinical Trials in Developing and Emerging Countries: Review and Case Study Kevin D. Hill and Jennifer S. Li 39 The Importance of Geographic Differences in Pediatric Clinical Trials Alexandar Cvetkovich Muntañola Part VIII: CLINICAL EFFICACY AND SAFETY ENDPOINTS 40 Clinical Laboratory Testing in Clinical Trials for Pediatric Subjects Andrew E. Mulberg and Ethan D. Hausman 41 Surrogate Endpoints: Application in Pediatric Clinical Trials Geert Molenberghs 42 Clinical Outcome Assessments for Clinical Trials in Children Elektra J. Papadopoulos, Donald L. Patrick, Melissa S. Tassinari, Andrew E. Mulberg, Carla Epps, Anne R. Pariser and Laurie B. Burke 43 Challenges in Evaluating the Safety of Pediatric Therapeutic Agents in Trials and Post-Marketing Studies Ann W. McMahon, Chris Feudtner and Dianne Murphy 44 Endpoints in Rare Diseases Anne R. Pariser and Lynne P. Yao Part IX: FORMULATION, CHEMISTRY, AND MANUFACTURING CONTROLS 45 Formulation, Chemistry, and Manufacturing Controls Gerard P. McNally and Aniruddha M. Railkar 46 Drug Delivery Challenges for the Pediatric Patient: Novel Forms for Consideration Ann Zajicek 47 The Jelly Bean Test: A Novel Technique To Help Children Swallow Medications Robbyn E. Sockolow and Aliza B. Solomon Index
£102.56
John Wiley and Sons Ltd Dentists Guide to Medical Conditions Medications
Book SynopsisThe second edition of Dentist''s Guide to Medical Conditions, Medications and Complications continues to provide quick-access, clinical information on the dental treatment of patients with common systemic conditions and medical complications. Expanded in this second edition is information about patient medications. Ideal for general practitioners and students in advanced general dentistry programs, the book outlines protocols for treating patients with common conditions, presents essential drug interaction information, and guides the dental professional through prevention and management of in-office medical emergencies.Table of ContentsAcknowledgments xii Introduction: Integration of Medicine in Dentistry xiv Section I: Patient Assessment 1 1. Routine History-Taking and Physical Examination 3 2. History and Physical Assessment of the Medically Complex Dental Patient 24 Section II: Pharmacology 33 3. Essentials in Pharmacology: Drug Metabolism, Cytochrome P450 Enzyme System, and Prescription Writing 35 4. Local Anesthetics Commonly Used in Dentistry: Assessment, Analysis, and Associated Dental Management Guidelines 54 5. Pain Physiology, Analgesics, Opioid Dependency Maintenance Therapies, Multimodal Analgesia, and Pain Management Algorithms 67 6. Odontogenic Infections, Antibiotics, and Infection Management Protocols 110 7. Antifungals Commonly Used in Dentistry: Assessment, Analysis, and Associated Dental Management Guidelines 150 8. Antivirals Commonly Used in Dentistry: Assessment, Analysis, and Associated Dental Management Guidelines 155 Section III: Acute Care and Stress Management 159 9. Management of Medical Emergencies: Assessment, Analysis, and Associated Dental Management Guidelines 161 10. Oral and Parenteral Conscious Sedation for Dentistry: Assessment, Analysis, and Associated Dental Management Guidelines 183 Section IV: Hematopoietic System 199 11. Complete Blood Count: Assessment, Analysis, and Associated Dental Management Guidelines 201 12. Red Blood Cells Associated Disorder: Anemia: Assessment, Analysis, and Associated Dental Management Guidelines 209 13. Red Blood Cells Associated Disorder: Polycythemia: Assessment, Analysis, and Associated Dental Management Guidelines 222 14. Red Blood Cells Associated Disorder: Hemochromatosis: Assessment, Analysis, and Associated Dental Management Guidelines 225 Section V: Hemostasis and Associated Bleeding Disorders 229 15. Primary and Secondary Hemostasis: Normal Mechanisms, Disease States, and Coagulation Tests: Assessment, Analysis, and Associated Dental Management Guidelines 231 16. Platelet Disorders: Thrombocytopenia, Platelet Dysfunction, and Thrombocytosis: Assessment, Analysis, and Associated Dental Management Guidelines 243 17. VonWillebrand’s Disease: Assessment, Analysis, and Associated Dental Management Guidelines 250 18. Coagulation Disorders: Common Clotting Factor Deficiency Disease States, Associated Systemic and/or Local Hemostasis Adjuncts, and Dental Management Guidelines 254 19. Anticoagulants: Assessment, Analysis, and Associated Dental Management Guidelines 262 Section VI: Cardiology and Renal Disease 273 20. Rheumatic Fever: Assessment, Analysis, and Associated Dental Management Guidelines 275 21. Infective Endocarditis and Current Premedication Prophylaxis Guidelines 279 22. Hypertension and Target Organ Disease States: Assessment, Analysis, and Associated Dental Management Guidelines 288 23. Cerebral Circulation Diseases TIAs and CVAs: Assessment, Analysis, and Associated Dental Management Guidelines 300 24. Coronary Circulation Diseases, Classic Angina, and Myocardial Infarction: Assessment, Analysis, and Associated Dental Management Guidelines 302 25. Congestive Heart Failure: Assessment, Analysis, and Associated Dental Management Guidelines 311 26. Cardiac Arrhythmias: Assessment, Analysis, and Associated Dental Management Guidelines 315 27. Peripheral Circulation Disease 318 28. Renal Function Tests, Renal Disease, and Dialysis: Assessment, Analysis, and Associated Dental Management Guidelines 319 Section VII: Pulmonary Diseases 331 29. Pulmonary Function Tests and Sedation with Pulmonary Diseases: Assessment, Analysis, and Associated Dental Management Guidelines 333 30. Upper Airway Disease: Allergic Rhinitis, Sinusitis, and Streptococcal Pharyngitis: Assessment, Analysis, and Associated Dental Management Guidelines 337 31. Asthma and Airway Emergencies: Assessment, Analysis, and Associated Dental Management Guidelines 341 32. Chronic Bronchitis and Smoking Cessation 348 33. Emphysema: Assessment, Analysis, and Associated Dental Management Guidelines 356 34. Chronic Obstructive Pulmonary Disease: Assessment, Analysis, and Associated Dental Management Guidelines 358 35. Obstructive Sleep Apnea: Assessment, Analysis, and Associated Dental Management Guidelines 365 36. Tuberculosis: Assessment, Analysis, and Associated Dental Management Guidelines 367 Section VIII: Clinical Pharmacology 375 37. Prescribed and Nonprescribed Medications: Assessment, Analysis, and Associated Dental Management Guidelines 377 Section IX: Endocrinology 383 38. Introduction to Endocrinology and Diabetes: Assessment, Analysis, and Associated Dental Management Guidelines 385 39. Thyroid Gland Dysfunctions: Assessment, Analysis, and Associated Dental Management Guidelines 403 40. Adrenal Gland Disease States: Assessment, Analysis, and Associated Dental Management Guidelines 408 41. Parathyroid Dysfunction Disease States: Assessment, Analysis, and Associated Dental Management Guidelines 417 42. Growth Hormone Dysfunction and Endocrine Tissues of the Reproductive System 433 Section X: Seizure Disorders 437 43. Classic Seizures: Assessment, Analysis, and Associated Dental Management Guidelines 439 Section XI: Gastrointestinal Conditions and Diseases 447 44. Gastrointestinal Disease States and Associated Oral Cavity Lesions: Assessment, Analysis, and Associated Dental Management Guidelines 449 Section XII: Hepatology 465 45. Liver Function Tests, Hepatitis, and Cirrhosis: Assessment, Analysis, and Associated Dental Management Guidelines 467 Section XIII: Postexposure Prevention and Prophylaxis 493 46. Needle-Stick Exposure Protocol and CDC Recommendations for Dental Health-Care Providers Infected with the Hepatitis B Virus 495 Section XIV: Infectious Diseases 503 47. Human Immunodeficiency Virus, Herpes Simplex and Zoster, Lyme Disease, MRSA Infection, and Sexually Transmitted Diseases 505 Section XV: Oral Lesions and Dentistry 539 48. Therapeutic Management of Oral Lesions in the Immune-Competent and the Immune-Compromised Patient in the Dental Setting 541 Section XVI: The Female Patient: Pregnancy, Lactation, and Contraception 565 49. Pregnancy, Lactation, and Contraception: Assessment and Associated Dental Management Guidelines 567 Section XVII: Rheumatology: Diseases of the Joints, Bones, and Muscles 587 50. Classic Rheumatic Diseases: Assessment and Associated Dental Management Guidelines 589 Section XVIII: Oncology: Head and Neck Cancers, Leukemias, Lymphomas, and Multiple Myeloma 625 51. Head and Neck Cancers and Associated Dental Management Guidelines 627 Section XIX: Psychiatry 661 52. Psychiatric Conditions: Assessment of Disease States and Associated Dental Management Guidelines 663 Section XX: Transplants 683 53. Organ Transplants, Immunosuppressive Drugs, and Associated Dental Management Guidelines 685 Section XXI: Common Laboratory Tests 695 54 Comprehensive Metabolic Panel and Common Hematological Tests 697 Appendix: Suggested Reading 699 Index 743
£999.99
John Wiley and Sons Ltd Diabetes Mellitus and Oral Health
Book SynopsisDiabetes Mellitus and Oral Health: An Interprofessional Approach is a practical tool for dentists and dental hygienists providing oral health care to patients with diabetes mellitus. Firmly grounded in the latest evidence, the book addresses medical considerations, dental considerations, and case scenarios from clinical practice in three easily accessible sections.The first section on medical considerations reviews the definition of diabetes and discusses underlying pathologic mechanisms, classification, diagnosis, and medical complications of the disease. It also promotes the comprehensive management of patients with diabetes in the dental office, with a thorough discussion of lifestyle changes and medications used to treat diabetes.The second section on dental considerations provides guidance on how treat patients with diabetes. Oral complications will be covered in detail, with a focus on management and treatment strategies that can be used in the dTable of ContentsContributors ix Acknowledgments xi Introduction xiii Section 1 Medical considerations 1 1 Etiology of diabetes mellitus 3Ravichandran Ramasamy and Ann Marie Schmidt 2 Classification, epidemiology, diagnosis, and risk factors of diabetes 27Jeffrey M. Curtis and William C. Knowler 3 Medical complications of diabetes mellitus 45Lewis W. Johnson and Ruth S. Weinstock 4 Glycemic treatment of diabetes mellitus 69Harpreet Kaur and Ruth S. Weinstock Section 2 Dental considerations 97 5 Management of the patient with diabetes mellitus in the dental office 99Brian L. Mealey 6 Periodontal disease as a complication of diabetes mellitus 121George W. Taylor, Dana T. Graves, and Ira B. Lamster 7 The influence of periodontal disease on glycemic control in diabetes 143Dana Wolf and Evanthia Lalla 8 Non-periodontal oral complications of diabetes mellitus 157Ira B. Lamster 9 Identification of dental patients with undiagnosed diabetes 191Evanthia Lalla, Dana Wolf, and Ira B. Lamster Section 3 Case reports 203 Case 1 A patient with type 1 diabetes mellitus is seen for dental care 205Ira B. Lamster, Nurit Bittner, and Daniel Lorber Case 2 A patient with type 2 diabetes mellitus requires oral surgery 209Ira B. Lamster, Nurit Bittner, and Daniel Lorber Case 3 A patient with diabetes mellitus has a hypoglycemic episode in the dental office 215Ira B. Lamster, Nurit Bittner, and Daniel Lorber Case 4 The patient with diabetes mellitus and xerostomia 221Ira B. Lamster, Nurit Bittner, and Daniel Lorber Case 5 A patient diagnosed with diabetes mellitus after comprehensive prosthodontic rehabilitation 229Ira B. Lamster, Nurit Bittner, and Daniel Lorber Case 6 Prosthodontic treatment for the newly diagnosed patient with type 2 diabetes mellitus 237Ira B. Lamster, Nurit Bittner, and Daniel Lorber Index 247
£69.30
John Wiley & Sons Inc BioCeramics with Clinical Applications
Book SynopsisThis publication offers a unique approach that links the materials science of bioceramics to clinical needs and applications.Providing a structured account of this highly active area of research, the book reviews the clinical applications in bone tissue engineering, bone regeneration, joint replacement, drug-delivery systems and biomimetism, this book is an ideal resource for materials scientists and engineers, as well as for clinicians.From the contents:Part I Introduction1. Bioceramics2. Biomimetics Part II Materials 3. Calcium Phosphate Bioceramics4. Silica-based Ceramics: Glasses5. Silica-based Ceramics: Mesoporous Silica6. Alumina, Zirconia, and Other Non-oxide Inert Bioceramics7. Carbon-based Materials in Biomedicine Part III Material Shaping 8. Cements9. Bioceramic Coatings for Medical Implants10. Scaffold Designing Part IV Research on Future CeraTable of ContentsList of Contributors xiii Preface xv Part I Introduction 1 1. Bioceramics 3 María Vallet-Regí 1.1 Introduction 3 1.2 Reactivity of the Bioceramics 4 1.3 First, Second, and Third Generations of Bioceramics 6 1.4 Multidisciplinary Field 7 1.5 Solutions for Bone Repairing 8 1.6 Biomedical Engineering 13 Recommended Reading 15 2. Biomimetics 17 María Vallet-Regí 2.1 Biomimetics 17 2.2 Formation of Hard Tissues 18 2.3 Biominerals versus Biomaterials 19 Recommended Reading 22 Part II Materials 23 3. Calcium Phosphate Bioceramics 25 Daniel Arcos 3.1 History of Calcium Phosphate Biomaterials 25 3.2 Generalities of Calcium Phosphates 26 3.3 In vivo Response of Calcium Phosphate Bioceramics 28 3.4 Calcium Hydroxyapatite-Based Bioceramics 30 3.4.1 Stoichiometric Hydroxyapatite (HA) 31 3.4.2 Calcium Deficient Hydroxyapatites (CDHA) 37 3.4.3 Carbonated Hydroxyapatites (CHA) 39 3.4.4 Silicon-Substituted Hydroxyapatite (Si-HA) 40 3.4.5 Hydroxyapatites of Natural Origin 45 3.5 Tricalcium Phosphate-Based Bioceramics 50 3.5.1 -Tricalcium Phosphate (-TCP) 50 3.5.2 -Tricalcium Phosphate (-TCP) 53 3.6 Biphasic Calcium Phosphates (BCP) 55 3.6.1 Chemical and Structural Properties 55 3.6.2 Preparation Methods 56 3.6.3 Clinical Applications 56 3.7 Calcium Phosphate Nanoparticles 57 3.7.1 General Properties and Scope of Calcium Phosphate Nanoparticles 57 3.7.2 Preparation Methods of CaP Nanoparticles 58 3.7.3 Clinical Applications 60 3.8 Calcium Phosphate Advanced Biomaterials 60 3.8.1 Scaffolds for in situ Bone Regeneration and Tissue Engineering 60 3.8.2 Drug Delivery Systems 62 References 65 4. Silica-based Ceramics: Glasses 73 Antonio J. Salinas 4.1 Introduction 73 4.1.1 What Is a Glass? 73 4.1.2 Properties of Glasses 75 4.1.3 Structure of Glasses 75 4.1.4 Synthesis of Glasses 76 4.2 Glasses as Biomaterials 78 4.2.1 First Bioactive Glasses (BGs): Melt-Prepared Glasses (MPGs) 79 4.2.2 Other Bioactive MPGs 80 4.2.3 Bioactivity Index and Network Connectivity 80 4.2.4 Mechanism of Bioactivity 81 4.3 Increasing the Bioactivity of Glasses: New Methods of Synthesis 82 4.3.1 Sol–Gel Glasses (SGGs) 82 4.3.2 Composition, Texture, and Bioactivity of SSGs 84 4.3.3 Biocompatibility of SGGs 86 4.3.4 SGGs as Bioactivity Accelerators in Biphasic Materials 86 4.3.5 Template Glasses (TGs) Bioactive Glasses with Ordered Mesoporosity 88 4.3.6 Atomic Length Scale in BGs: How the Local Structure Affects Bioactivity 91 4.3.7 New Reformulation of Hench’s Mechanism for TGs 93 4.3.8 Including Therapeutic Inorganic Ions in the Glass Composition 94 4.4 Strengthening and Adding New Capabilities to Bioactive Glasses 95 4.4.1 Glass Ceramics (GCs) 95 4.4.2 Composites Containing Bioactive Glasses 97 4.4.3 Sol–Gel Organic–Inorganic Hybrids (O-IHs) 98 4.5 Non-silicate Glasses 99 4.5.1 Phosphate Glasses 99 4.5.2 Borate Glasses 100 4.6 Clinical Applications of Glasses 101 4.6.1 Bioactive Silica Glasses 101 4.6.2 Inert Silica Glasses 106 4.6.3 Phosphate Glasses 106 4.6.4 Borate Glasses 107 Recommended Reading 107 5. Silica-based Ceramics: Mesoporous Silica 109 Montserrat Colilla 5.1 Introduction 109 5.2 Discovery of Ordered Mesoporous Silicas 110 5.3 Synthesis of Ordered Mesoporous Silicas 111 5.3.1 Hydrothermal Synthesis 112 5.3.2 Evaporation-Induced Self-Assembly (EISA) Method 119 5.4 Mechanisms of Mesostructure Formation 119 5.5 Tuning the Structural Properties of Mesoporous Silicas 122 5.5.1 Micellar Mesostructure 123 5.5.2 Type of Mesoporous Structure 128 5.5.3 Mesopore Size 131 5.6 Structural Characterization of Mesoporous Silicas 132 5.7 Synthesis of Spherical Mesoporous Silica Nanoparticles 135 5.7.1 Aerosol-Assisted Synthesis 136 5.7.2 Modified Stöber Method 137 5.8 Organic Functionalization of Ordered Mesoporous Silicas 138 5.8.1 Post-synthesis Functionalization (“Grafting”) 139 5.8.2 Co-condensation (“One-Pot” Synthesis) 140 5.8.3 Periodic Mesoporous Organosilicas 141 References 141 6. Alumina, Zirconia, and Other Non-oxide Inert Bioceramics 153 Juan Peña López 6.1 A Perspective on the Clinical Application of Alumina and Zirconia 153 6.1.1 Alumina 155 6.1.2 Zirconia 158 6.2 Novel Strategies Based on Alumina and Zirconia Ceramics 160 6.2.1 From Alumina Toughened Zirconia to Alumina Matrix Composite 160 6.2.2 Introduction of Different Species in Zirconia 161 6.2.3 Improvement of Surface Adhesion 162 6.3 Non-oxidized Ceramics 163 6.3.1 Silicon Nitride (Si3N4) 163 6.3.2 Silicon Carbide (SiC) 164 References 164 7. Carbon-based Materials in Biomedicine 175 Mercedes Vila 7.1 Introduction 175 7.2 Carbon Allotropes 175 7.2.1 Pyrolytic Carbon 176 7.2.2 Carbon Fibers 177 7.2.3 Fullerenes 177 7.2.4 Carbon Nanotubes 179 7.2.5 Graphene 181 7.2.6 Diamond and Amorphous Carbon 184 7.3 Carbon Compounds 186 7.3.1 Silicon Carbide 186 7.3.2 Boron Carbide 187 7.3.3 Tungsten Carbide 188 References 188 Part III Material Shaping 193 8. Cements 195 Oscar Castaño and Josep A. Planell Abbreviations 195 Glossary 196 8.1 Introduction 197 8.1.1 Brief History 197 8.1.2 Definition and Chemistry 199 8.1.3 Description of the Different CaP Cements 200 8.1.4 State of the Art 201 8.2 Calcium Phosphate Cements 206 8.2.1 Types 206 8.2.2 Mechanisms 206 8.2.3 Relevant Experimental Variables 207 8.2.4 Material Characterization 211 8.2.5 Reaction Evolution of Cements 220 8.2.6 Additives and Strategies to Enhance Properties 222 8.2.7 Biological Characterization and Bioactive Behavior 224 8.3 Applications 229 8.3.1 Bone Defect Repair 229 8.3.2 Drug Delivery Systems 232 8.4 Future Trends 232 8.5 Conclusions 233 References 234 9. Bioceramic Coatings for Medical Implants 249 M. Victoria Cabañas 9.1 Introduction 249 9.2 Methods to Modify the Surface of an Implant 250 9.2.1 Deposited Coatings 251 9.2.2 Conversion Coatings 257 9.3 Bioactive Ceramic Coatings 258 9.3.1 Clinical Applications 259 9.3.2 Calcium Phosphates-Based Coatings 260 9.3.3 Silica-based Coatings: Glass and Glass-Ceramics 268 9.3.4 Bioactive Ceramic Layer Formation on a Metallic Substrate 270 9.4 Bioinert Ceramic Coatings 272 9.4.1 Titanium Nitride and Zirconia Coatings 273 9.4.2 Carbon-based Coatings 275 References 279 10. Scaffold Designing 291 Isabel Izquierdo-Barba 10.1 Introduction 291 10.2 Essential Requirements for Bone Tissue Engineering Scaffolds 293 10.3 Scaffold Processing Techniques 296 10.3.1 Foam Scaffolds 297 10.3.2 Rapid Prototyping Scaffolds 301 10.3.3 Electrospinning Scaffolds 305 References 307 Part IV Research on Future Ceramics 315 11. Bone Biology and Regeneration 317 Soledad Pérez-Amodio and Elisabeth Engel 11.1 Introduction 317 11.2 The Skeleton 318 11.3 Bone Remodeling 320 11.4 Bone Cells 322 11.4.1 Bone Lining Cells 322 11.4.2 Osteoblasts 323 11.4.3 Osteocytes 323 11.4.4 Osteoclasts 324 11.5 Bone Extracellular Matrix 327 11.6 Bone Diseases 327 11.6.1 Osteoporosis 328 11.6.2 Paget’s Disease 329 11.6.3 Osteomalacia 329 11.6.4 Osteogenesis Imperfecta 329 11.7 Bone Mechanics 329 11.8 Bone Tissue Regeneration 333 11.8.1 Calcium Phosphate and Silica-based Bioceramics 333 11.8.2 Bioactive Glasses 334 11.8.3 Calcium Phosphate Cements 335 11.9 Conclusions 336 References 336 12. Ceramics for Drug Delivery 343 Miguel Manzano 12.1 Introduction 343 12.2 Drug Delivery 344 12.3 Drug Delivery from Calcium Phosphates 346 12.3.1 Drug Delivery from Hydroxyapatite 346 12.3.2 Drug Delivery from Tricalcium Phosphates 348 12.3.3 Drug Delivery from Calcium Phosphate Cements 348 12.4 Drug Delivery from Silica-based Ceramics 351 12.4.1 Drug Delivery from Glasses 351 12.4.2 Drug Delivery from Mesoporous Silica 355 12.5 Drug Delivery from Carbon Nanotubes 363 12.6 Drug Delivery from Ceramic Coatings 365 References 366 13. Ceramics for Gene Transfection 383 Blanca González 13.1 Gene Transfection 383 13.2 Gene Transfection Based on Nonviral Vectors 386 13.3 Ceramic Nanoparticles for Gene Transfection 388 13.3.1 Calcium Phosphate Nanoparticles 391 13.3.2 Mesoporous Silica Nanoparticles 393 13.3.3 Carbon Allotropes (Fullerenes, CNTs, Graphene Oxide) 397 13.3.4 Magnetic Iron Oxide Nanoparticles 403 References 410 14. Ceramic Nanoparticles for Cancer Treatment 421 Alejandro Baeza 14.1 Delivery of Nanocarriers to Solid Tumors 421 14.1.1 Special Issues of Tumor Vasculature: Enhanced Permeation and Retention Effect (EPR) 422 14.1.2 Tumor Microenvironment 423 14.2 Ceramic Nanoparticle Pharmacokinetics in Cancer Treatment 424 14.2.1 Biodistribution and Excretion/Clearance Pathways 424 14.2.2 Toxicity of the Ceramic Nanoparticles 426 14.3 Cancer-targeted Therapy 428 14.3.1 Endocytic Mechanism of Targeted Drug Delivery 428 14.3.2 Specific Tumor Active Targeting 430 14.3.3 Angiogenesis-associated Active Targeting 432 14.4 Ceramic Nanoparticles for Cancer Treatment 434 14.4.1 Mesoporous Silica Nanoparticles 434 14.4.2 Calcium Phosphates Nanoparticles 440 14.4.3 Carbon Allotropes 440 14.4.4 Iron Oxide Nanoparticles and Hyperthermia 442 14.5 Imaging and Theranostic Applications 443 References 446 Index 457
£89.25
John Wiley and Sons Ltd Handbook of Dermatology
Book SynopsisThe Handbook of Dermatology consolidates the essential information required for best-practice patient care into one pocket-sized volume. This indispensable reference guide enables practicing and prospective dermatologists to easily look up information on a wide range of dermatological diseases and quickly access the algorithms, protocols, guidelines, and staging and scoring systems that are vital to both clinical practice and exam success. Written and edited by former residents and attending physicians, the Handbook contains up-to-date information on general dermatology, surgery, and therapeutics.Table of ContentsPreface xv Acknowledgments xvii Part 1 General Dermatology 1 Common Work-Ups, Signs, and Management 3 Dermatologic Differential Algorithm 3 Direct Immunofluorescence (Dif) 3 False positive/negative DIFs 3 Workup Quick Reference Orders 4 Acne 6 Alopecia Workup 7 Telogen effluvium 10 Androgenic alopecia 10 Alopecia areata 11 Other alopecia treatments 12 Aphthosis Workup and Treatment 13 Dermatologic Signs 15 Folliculitis 21 Melasma 22 Immunology and Immunologic Disease 24 Lupus Erythematosus 24 Autoantibody 26 Sensitivities and specificities 26 In connective tissue diseases 28 Anti‐nuclear antibodies 29 ANCA (Anti‐neutrophil cytoplasmic antibodies) 30 Treatment of ANCA‐associated vasculitis 30 Vasculitis 31 Small vessel vasculitis 31 Medium vessel vasculitis 33 Large vessel vasculitis 34 Cryoglobulinemia 34 Bullous Disorders 36 Intracorneal/subcorneal 36 Intraepidermal 36 Suprabasilar 37 Subepidermal with little inflammation 37 Epidermolysis bullosa 39 Major bullous diseases – clinicopathologic findings 42 Complement 46 Angioedema and complement levels 46 Complement deficiencies 47 GVHD 47 HLA associations 48 Th profiles 50 Special Sites: Glands, Nail, Bone, Mucosa 51 Glands 51 Nail terminology 53 Disorders or drugs associated with nail, Bone, or ocular findings 57 Genital ulcers 67 Infection and Infestations 68 Fungal Disease / Mycoses 68 Laboratory tests 68 Superficial mycoses 68 Cutaneous mycoses 69 Subcutaneous mycoses 71 Systemic mycoses 73 Opportunistic mycoses 75 Viruses and diseases 78 Human papilloma virus 79 Other viral diseases 80 Infections/Bugs 83 Vector‐borne diseases 83 Creatures in dermatology 88 Contact and Plant Dermatitis 93 Patch testing 93 Common contact allergens 95 Allergic vs. irritant contact dermatitis 104 Allergens – location specific 105 Features suggestive of specific irritant/toxin 106 Plants and Dermatoses 106 Tumors and Infiltrates 109 Cutaneous T Cell Lyphoma 109 Cutaneous B‐cell lymphoma 113 Leukemia cutis 113 Monoclonal Gammopathies in Dermatology 114 Tumors and gene associations 115 For Melanoma, BCC, and SCC, see Skin Cancer 221 Systemic and Metabolic Diseases 117 Amyloidoses 117 Histiocytosis 119 Xanthomas 124 Hyperlipoproteinemias 125 Vitamin Deficiencies/Hypervitaminoses 127 Pediatric and Pregnancy Dermatology 131 Vascular tumors and malformation 131 Infantile Hemangioma (IH) Management 132 Neonatal vesiculopustular eruptions 137 Genodermatoses 142 Chromosome abnormalities 171 Disorders of cornification 171 Disorders of connective tissue 175 Ehlers–Danlos 177 Collagen types 178 Disorder of hair, Nail, ectoderm 179 Tumor syndromes 185 Disorders of vascularization 186 Disorders of metabolism 189 Porphyrias 191 Disorders of pigmentation 193 Immunodeficiency syndromes 196 Miscellaneous 198 Dermatoses of pregnancy 200 Dermoscopy and Dermatopathology 202 Dermoscopy 202 Dermatopathology 206 Histochemical staining 206 Immunohistochemical staining 207 Pathologic bodies 210 Cysts 214 Other derm path buzzwords, Patterns, DDx 215 Part 2 Surgical and Cosmetic Dermatology 219 Surgical Dermatology 221 Skin cancer 221 Surgical margin guidelines 221 Indication for Mohs micrographic surgery 222 Melanoma 223 Squamous cell carcinoma (SCC) 228 Prophylactic antibiotics and antivirals 230 Guideline for Prophylactic antibiotics 230 Algorithm for antibiotic prophylaxis 231 Guideline for prophylactic antivirals 231 Antiseptic scrubs 232 Anesthetics 234 Dose calculation 234 Standard formula for buffered Lidocaine 234 Tumescent anesthesia 234 Topical anesthetic (see drug section pg. 316) 235 Adverse reaction to local anesthetics 235 Local anesthetic 236 Nerve blocks 237 Surgical anatomy 237 Anatomy of the face 237 Danger zones in surgery 242 Dermatomal distribution of sensory nerves 244 Anatomy of the lower extremity venous system 245 Anatomy of the nail 246 Cutaneous reconstruction 247 Undermining depths in reconstruction 248 Reconstruction algorithm: STAIRS 248 Sutures 260 Absorbable 260 Nonabsorbable 261 Suture removal time 262 Electrosurgery 262 Wound healing 262 Wound dressing 263 Cosmetic Dermatology 264 Laser 264 Laser fundamentals 264 Laser treatment of tattoo pigment 266 Photoinduced eye injury 267 Laser wavelength depth of penetration and the electromagnetic spectrum 268 Absorption spectra of major skin chromophores 268 Photodynamic therapy 269 Photosensitizer properties and options 269 PDT Protocol 270 UV spectrum 271 UV spectrum and wavelengths 271 UVB protection vs SPF 272 UV protection measurements 272 UV associations/specificities 273 Glogau wrinkle scale 273 Fitzpatrick skin type 274 Chemical peels 274 Pre‐peel consideration 274 Peeling agents 275 Botulinum toxin 277 Injectable for adipolysis 280 Fillers 281 Protocol for vascular occlusion from fillers 288 Venous disease treatment 288 Vein treatment algorithm 288 Sclerotherapy 289 Preparing dilution of sclerosants 290 CEAP classification for venous disease 292 Venous clinical severity score 292 Part 3 Drugs and Therapies 293 Medication Quick Reference 295 Topical steroids classified by strength 295 Nonsteroidals 297 Commonly used drugs in dermatology 297 Systemic Medications 302 Antimalarials 302 Immunosuppressive agents 303 Systemic retinoids 306 Biologics 307 General Reference 310 Metric measurements 310 Dose calculations 310 Topical medication dispensing and absorption 310 Corticosteroid Dosage Equivalence 311 Acne – Topical 311 Antibiotics/antimicrobial 311 Keratolytics 312 Retinoids 313 Others 313 Acne – Oral 314 Antibiotics 314 Retinoids 315 Others 315 Analgesics 315 Anesthetics – topical (see also topical anesthetic pg. 235) 316 Anesthetics – topical compounded 316 Antibiotics 316 Topical/antiseptic 316 Systemic 317 Preoperative prophylaxis see pg. 230 Postoperative skin infection 319 Sensitivity 321 Regimens 322 STDs 323 Antifungals 324 Topical 324 Oral 325 Antifungal regimens 327 Candidal infection 327 Pityrosporum folliculitis 327 Onychomycosis 327 Tinea versicolor (Malassezia) 328 Tinea capitis 328 Tinea corporis 328 Tinea pedis 329 Antiparasitics 330 Scabies 330 Lice 330 Antivirals 331 HSV 331 Herpes zoster/VZV 333 Genital warts 333 Verruca vulgaris 334 Molluscum 334 Antihistamines 334 Sedating 335 Nonsedating 335 H2‐blockers 335 Antipruritic 336 Topical 336 Oral 336 Anxiolytics/Sedation 338 Benzodiazepines 338 Antihistamines 339 Bleaching Agents/Depigmenting Agents 340 Hair 341 Alopecia – androgenic 341 Alopecia – areata 341 Hypertrichosis 342 Hypotrichosis – eyelash 342 Hyperhidrosis 342 Psoriasis 343 Topical agents 343 Tar 343 Anthralin/dithranol 343 Systemic agents 343 (see also Systemic Medications pg. 306) Rosacea 344 Antibiotics/antimicrobial – topical 344 Keratolytics 344 Vasoconstrictor 344 Other 344 Antibiotics – systemic 344 Seborrheic Dermatitis 345 Skin Cancer – Topical and Oral Chemotherapy 345 Actinic keratoses (AK) 345 Basal cell carcinoma (BCC) 346 CTCL 346 Melanoma 347 Vasoactive/Antiplatelet Agents 347 Vitamins/Nutritional Supplements 348 Wound Care 348 Miscellaneous Meds 348 Cytochrome P‐450 interactions 349 Pregnancy Categories of Commonly Used Dermatologic Agents 350 Common Dermatologic Drugs and Teratogenic Effects 351 Dermatologic Drugs Reportedly Associated with Contraceptive Failure 352 Drug Eruptions 352 Chemotherapeutic Agents and Skin Changes 355 Antidote to extravasation of chemotherapeutic agents 358 UV Light Treatment 359 UVA/UVB dosing 359 NBUVB dosing 359 PUVA 359 Toxic Epidermal Necrolysis (TEN) Protocol 361 Diagnosis of TEN 361 Triage algorithm for TEN patients 362 Treatment for all TEN patients 363 Appendix I American Burn Assocation Burn Center Referral Criteria 364 Appendix SCORTEN Score 365 Appendix III IVIg 365 Appendix IV Further Reading for TEN/SJS 366 Index 367 Color plate section can be found facing page 208
£46.95
John Wiley and Sons Ltd Male Lower Urinary Tract Symptoms and Benign
Book SynopsisProvides urologists of all levels with a practical, highly clinical guide to the variety of different symptoms and problems concerning the male lower urinary tract, including benign prostatic hyperplasia, one of the conditions that urologists most regularly encounter.Table of ContentsContributors, vii 1 Etiology and Pathogenesis, 1 Robert H. Getzenberg & Prakash Kulkarni 2 Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia: Epidemiology, Correlates, and Risk Factors, 10 Raymond C. Rosen & Benjamin N. Breyer 3 Clinical Assessment and Diagnosis of Lower Urinary Tract Dysfunction: United States, 22 Christopher P. Filson & John T. Wei 4 Clinical Assessment and Diagnosis of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: Europe, 37 Stavros Gravas & Jean J. M. C. H. de la Rosette 5 Clinical Assessment and Diagnosis of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: Primary Care, 47 Matt T. Rosenberg, John B. Riley & Marty M. Miner 6 Watchful Waiting, 59 Reginald Bruskewitz 7 α-Adrenergic Antagonists for Lower Urinary Symptoms Secondary to Benign Prostatic Hyperplasia, 70 Nathaly François, Raunak D. Patel & Kevin T. McVary 8 5α-Reductase Inhibitors, 90 Claudius Füllhase & Roberto Soler 9 Antimuscarinics, 100 Nadir I. Osman & Christopher R. Chapple 10 The Use of Phosphodiesterase Type 5 Inhibitors in the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia, 113 Casey Lythgoe & Kevin T. McVary 11 Combination Medical Therapy for Male Lower Urinary Tract Symptoms, 129 Claus G. Roehrborn 12 Complementary Therapy, 154 Aaron E. Katz & Anne Darves-Bornoz 13 Open Simple Prostatectomy, 164 Annika Herlemann, Matthias Oelke & Christian Gratzke 14 Minimally Invasive Therapies, 175 Mauro Gacci, Matteo Salvi and Arcangelo Sebastianelli 15 Holmium Laser Prostatectomy, 184 Simon van Rij & Peter J. Gilling 16 Benign Prostatic Hyperplasia: GreenLight Laser Therapy, 191 Alexis E. Te & Bilal Chughtai 17 Principles of Electrocautery-Based Techniques, 201 Aaron M. Bernie & Richard Lee Index, 211
£79.75
John Wiley and Sons Ltd Overactive Bladder
Book SynopsisOveractive Bladder: Practical Management provides urologists, gynecologists and other health practitioners with acomprehensive clinical guide to this very common problem, resulting in a perfect resource to consult time and time again. Beginning with an introductory section covering the definition and pathophysiolgy of OAB, it then moves on to cover evaluation, first-line management, second-line management and finally surgery. Well-illustrated throughout, each chapter begins with a key points box outlining the most important take-home messages. Also included are clear management algorithms to aid decision-making, ''Do''s and Don''t'' boxes to help avoid errors made, key references to the top journal articles, and the very latest guidelines from the EAU, AUA and other major urology societies. Chapters are written by the top names in the field and the entire book is expertly edited by Jacques Corcos, John Heesakkers and Scott MacDiarmid. The resulTable of ContentsList of Contributors vi Preface viii 1 Adolescent and transitional urology—an introduction 1 Part I: The kidney 2 Anatomical and cystic anomalies of the kidney 13 3 Stones 22 4 Prune]belly syndrome 29 Part II: The ureter 5 Renal function in adolescents 41Dr Kate Hillman and Professor Guy Neild 6 Structural anomalies and reconstruction of the ureter 49 7 Vesico]ureteric reflux 58 Part III: The bladder 8 The neuropathic bladder and spina bifida 75 9 Lower urinary tract replacement and reconstruction 91 10 Urinary diversion and undiversion 116 11 Other bladder conditions 122 12 Exstrophy and epispadias 128 13 Cloacal exstrophy 154 Part IV: The urethra 14 Posterior urethral valves 167 15 Hypospadias 177 Part V: Disorders of sex development 16 Scrotal abnormalities 193 17 The overvirilized female 202 18 The undervirilized male 218 19 Adolescent sexuality and counseling 232 Part VI: Neoplasia 20 Neoplastic disease: outcomes in survivors 239 Index 250
£79.75
John Wiley and Sons Ltd The Dentists Quick Guide to Medical Conditions
Book SynopsisWith increasing numbers of dental patients being elderly or having medical conditions, it is important for the dentist to understand how these conditions may impact dental treatment. The Dentist's Quick Guide to Medical Conditions presents the relevant information dentists needsymptoms, diagnostic tests, medications prescribed, and dental managementfor each disease and condition. Chapters will focus on each major bodily system, including respiratory, cardiovascular, hematologic, endocrine, gastrointestinal, immune, nervous, reproductive, and urinary, as well as chapters on the liver, kidneys, skin, and psychological conditions. Appendices list guidelines for antibiotic prophylaxis, additional conditions requiring antibiotics, and a quick list of diagnostic tests.Table of ContentsContributors x Foreword xi Preface xii 1 Gastrointestinal disorders 1 A. Peptic ulcer disease 1 B. Gastroesophageal reflux disease 4 C. Irritable bowel syndrome 6 D. Inflammatory bowel disease 7 a. Crohn’s disease 7 b. Ulcerative colitis 10 E. Diverticular disease 11 F. Acute pancreatitis 12 G. Celiac sprue 13 H. Pseudomembranous colitis 13 2 Medical conditions of the respiratory system 17 A. Respiratory diseases 17 a. Asthma 17 b. Chronic obstructive pulmonary diseases 23 c. Pulmonary tuberculosis 24 d. Obstructive sleep apnea 27 3 Disorders of the urinary system 30 A. Acute renal injury and chronic kidney disease 30 B. Kidney dialysis 37 C. Kidney transplant 39 D. Polycystic kidney disease 42 E. Benign prostatic hypertrophy 42 4 Diseases of the endocrine system 46 A. Diabetes 46 B. Thyroid diseases 50 C. Adrenal gland disorders 53 5 Disorders of the cardiovascular system 59 A. Hypertension 59 B. Angina Pectoris 68 Clinic 68 C. Myocardial infarction 70 D. Heart failure 73 E. Arrhythmias 75 F. Valvular heart disease 78 G. Epinephrine in cardiac patients 79 6 Pregnancy, lactation, and oral contraceptives 82 A. Pregnancy and lactation 82 B. Oral contraceptives 89 7 Disorders of the liver and gallbladder 93 A. Liver disease 93 a. Alcoholic liver disease and cirrhosis 98 b. Hepatitis 99 c. Liver transplant 103 B. Gallstones 105 8 Diseases of the neurological system 109 A. Parkinson’s disease 109 B. Multiple sclerosis 113 C. Seizures 116 9 Psychiatric disorders 125 Introduction 125 A. Antipsychotics 126 a. Typical antipsychotics 127 b. Atypical antipsychotics 128 c. Anticholinergic medications 128 B. Antidepressants 132 a. Monoamine oxidase inhibitors 133 b. Tricyclics and tetracyclics 134 c. Selective serotonin reuptake inhibitors 135 d. Selective serotonin norepinephrine reuptake inhibitors (SNRIs) 136 e. Others 136 f. Summary: Dental interactions and side effects 136 C. Mood stabilizers 138 a. Lithium 139 b. Valproic acid (Depakote) 140 c. Lamotrigine (Lamictal) 140 d. Carbamazepine (Tegretol) 141 e. Oxcarbazepine (Trileptal) 141 D. Alcohol and other drugs with addictive potential 142 a. Alcohol 142 b. Sedatives and hypnotics 143 c. Opioids 143 d. Cocaine 145 10 Hematologic disorders and drugs that cause bleeding 149 A. Brief overview of the coagulation process 149 a. Thrombocytopenia 152 b. Thrombocytopathy 153 c. Antiplatelet medications 153 B. Bleeding disorders: Coagulation disorders 154 a. von Willebrand disease 154 b. Hemophilias 155 c. End-stage liver disease 156 d. Anticoagulation medications 157 11 Blood dyscrasias 171 A. Red blood cell disorders 174 a. Anemia 174 b. Myeloproliferative disorders 181 B. White blood cell disorders 182 a. Leukemia 182 b. Lymphoma 186 c. Multiple myeloma 187 12 Musculoskeletal and connective tissue disorders 193 A. Osteoporosis 193 B. Osteoarthritis 197 C. Rheumatoid arthritis 198 D. Gout 201 E. Fibromyalgia syndrome 203 F. Systemic lupus erythematosus 205 G. Sjögren’s syndrome 208 13 HIV and oral health care 214 14 Radiation and chemotherapy 237 Appendices Appendix A Antibiotic prophylaxis of the dental patient 252 Appendix B Common dental drug interactions 255 Appendix C Summary of tables/boxes 266 Appendix D Interpretation of common laboratory values 270 Index 274
£48.56
John Wiley and Sons Ltd Ibuprofen
Book SynopsisIbuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in bTable of ContentsList of Contributors xiii Preface xv 1 History and Development of Ibuprofen 1Kim D. Rainsford Summary 1 1.1 Introduction 1 1.2 Historical Background 5 1.3 Initial Stages 7 1.4 Compounds in Development 10 1.5 Ibufenac – Almost There, but for Liver Toxicity 12 1.6 More Setbacks 12 1.7 More Learning 12 1.8 Ibuprofen 12 1.8.1 First Clinical Trials 12 1.8.2 Gastrointestinal Safety 14 1.9 Achievements and Rewards at Last 15 1.10 Ultimate Recognition of Safety – OTC Status 17 1.11 Worldwide Developments 19 1.11.1 Evolving Applications of Ibuprofen 19 Acknowledgements 20 References 20 2 The Medicinal Chemistry of Ibuprofen 22Kenneth J. Nichol and David W. Allen 2.1 Introduction 22 2.2 The Discovery of Ibuprofen 22 2.3 Synthetic Routes to Ibuprofen 27 2.4 Biological Activities of Ibuprofen Analogues 31 2.5 Metabolites of Ibuprofen 36 2.5.1 Metabolites and Enantiomer Inversion 36 2.5.2 Synthesis of Metabolites 37 2.6 Ibuprofen Enantiomers 38 2.7 Physicochemical Aspects 42 Acknowledgements 43 References 43 3 The Pharmaceutics of Ibuprofen 50Fred Higton Summary 50 3.1 Physical and Chemical Characteristics of Ibuprofen 50 3.2 Products Available Worldwide 54 3.3 Solid Dose Presentations 54 3.3.1 Conventional Ibuprofen Tablets 56 3.3.2 In vitro/in vivo Testing 58 3.3.3 Sustained Release Preparations 60 3.3.4 Ibuprofen Fast Acting: Ibuprofen Salts and Derivatives 64 3.4 Liquids 67 3.5 Taste-Masking of Ibuprofen 67 3.6 Suppositories 69 3.7 Topical Presentations 70 3.8 Conclusion 72 References 72 4 The Pharmacokinetics of Ibuprofen in Humans and Animals 81Fakhreddin Jamali and Dion R. Brocks Summary 81 4.1 Absorption 82 4.2 Distribution 83 4.2.1 Protein Binding 83 4.2.2 Tissue Distribution 88 4.3 Clearance 92 4.3.1 Metabolism of Ibuprofen 93 4.3.2 Excretion of Ibuprofen 104 4.4 Interspecies Differences in Pharmacokinetics of (R)- and (S)-Ibuprofen 105 4.5 Relationship between Effect and Plasma Concentrations 106 4.5.1 Therapeutic Effects 106 4.5.2 Toxic Effects 107 4.6 Pharmacokinetics in Special Populations 108 4.6.1 Pharmacokinetics and Analgesic Effects in Patients in Pain 108 4.6.2 Febrile Children and Infants 114 4.6.3 Postoperative Paediatric Patients 115 4.6.4 Premature Infants 115 4.6.5 Juvenile Arthritis 116 4.6.6 Children with Cystic Fibrosis 116 4.6.7 Elderly Adults 117 4.6.8 Rheumatic Disease 117 4.6.9 Renal Insufficiency 118 4.6.10 Hepatic Disease 119 4.6.11 Burn Patients 119 4.6.12 Effect of Gender and Race 119 4.6.13 Effect of Operational Stessors 120 4.7 Drug Interactions 120 4.7.1 Anti-ulcer Medications 120 4.7.2 Zidovudine 121 4.7.3 Codeine and Oxycodone 121 4.7.4 Anti-hyperlipidemic Drugs 121 4.7.5 Oral Contraceptive Steroids 122 4.7.6 Self-interaction; Enantiomer–Enantiomer Interaction 123 4.7.7 Effect of Ibuprofen on the Pharmacokinetics of Other Drugs 123 4.7.8 Other Drugs 123 References 124 5 Pharmacology and Toxicology of Ibuprofen 132Kim D. Rainsford Summary 132 5.1 Introduction 133 5.2 Basic Pharmacology and Toxicology 134 5.2.1 The Relevance of Data from Animal Models to the Clinical Situation in Humans 134 5.2.2 Acute Anti-inflammatory Activity 136 5.2.3 Chronic Anti-inflammatory Activity 141 5.2.4 Analgesic Activity 143 5.2.5 Antipyretic Activity 149 5.2.6 General Toxicology 149 5.2.7 Effects on Prostaglandin Production Related to Pharmacological Activities 164 5.2.8 Effects on Leukotriene Production 180 5.2.9 Smooth Muscle Contractility 181 5.2.10 Effects on Nitric Oxide Production 181 5.2.11 Leucocytes and Vascular Permeability 182 5.2.12 Leukocyte Functions 188 5.2.13 Immune Functions 191 5.2.14 Effects on Articular Joint Integrity 192 5.2.15 Miscellaneous Biochemical and Cellular Actions 194 5.3 Experimental Therapeutics 196 5.3.1 Endotoxin Shock 196 5.3.2 Acute Lung Injury Induced by Exposure to Chemicals 198 5.3.3 Acute Myocardial Injury and Coronary Functions 199 5.3.4 Cerebral Injury 201 5.3.5 Tourniquet Shock Ischemia 202 5.3.6 Transcutaneous Hypoxia 202 5.3.7 Cytokines and Surgical Stress 203 5.3.8 Pleurisy from Delayed Hypersensitivity Reaction 203 5.3.9 Abdominal Adhesions 203 5.3.10 Uveitis 204 5.4 Clinical Pharmacology and Toxicology 204 5.4.1 Experimental Inflammation 204 5.4.2 Experimental Pain 205 5.4.3 Effects on Platelet Aggregation and Thrombosis 206 5.4.4 Gastrointestinal Injury and Bleeding 208 5.4.5 Hypersensitivity and Other Immunological Reactions 210 5.4.6 Gynaecological and Obstetric Uses 211 5.4.7 Effects on Lung Inflammation in Cystic Fibrosis 212 5.4.8 Malignant Conditions 212 5.4.9 Prevention of Cataract 213 5.5 Conclusions 214 References 214 6 Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases 237Walter F. Kean, Kim D. Rainsford and the late William W. Buchanan Summary 237 6.1 Introduction 238 6.2 Overview of Clinical Pharmacology 239 6.2.1 Pharmacokinetics Relevant to Therapy of Inflammatory Diseases and Pain 240 6.2.2 Anti-inflammatory and Analgesic Activities 245 6.2.3 Criteria for Determining Therapeutic Responses 247 6.3 NSAID-Related Adverse Drug Reactions and Toxicity 248 6.3.1 Gastrointestinal Side-Effects 248 6.3.2 Cardiovascular Reactions 251 6.3.3 Hepatic Reactions 251 6.3.4 Renal Adverse Reactions 251 6.3.5 Miscellaneous Reactions 253 6.4 Rheumatoid Arthritis 254 6.4.1 Early Studies at Low Doses 255 6.4.2 Later Higher]Dose Studies 257 6.5 Juvenile Idiopathic (Rheumatoid) Arthritis 261 6.6 Primary and Secondary Osteoarthritis 262 6.6.1 Acceleration of Cartilage and Bone Destruction 272 6.6.2 Therapeutic Aspects 273 6.6.3 Comparisons with Coxibs 274 6.7 Formulations 276 6.8 Variability in Response 276 6.9 Relation of Drug Kinetics to Clinical Response 277 6.10 Low Back Pain 278 6.11 Shoulder Pain 279 6.12 Reactive Arthritis (Reiter’s Syndrome) 280 6.13 Psoriatic Arthritis 280 6.14 Ankylosing Spondylitis 280 6.15 Gout 280 6.16 Fibromyalgia 281 6.17 Haemophiliac Arthritis 281 6.18 Postoperative Pain 281 6.19 Sports Injuries 282 6.20 Other Painful States 283 6.21 Cancer 284 6.22 Potential Non]analgesic Usage 285 6.23 The Elderly 285 6.24 Dexibuprofen 286 6.25 Conclusions 286 References 287 7 Safety and Efficacy of Non-prescription, Over-the]Counter (OTC) Ibuprofen 313Kim D. Rainsford Summary 313 7.1 Introduction 313 7.2 Analysis of Clinical Trials 315 7.2.1 Studies in Prospective Clinical Trials 317 7.3 Epidemiological Studies and Case Reports 327 7.4 Considerations for Special Groups 330 7.4.1 Use of Drugs in the Elderly 330 7.4.2 Safety in Pregnancy and Lactation 331 7.4.3 Uses and Safety in Sport and Exercise 334 7.5 Conclusions 336 References 336 8 Use of Ibuprofen in Dentistry 346Raymond A. Dionne, Sharon M. Gordon and Stephen A. Cooper Summary 346 8.1 Introduction 346 8.2 Analgesia 347 8.2.1 Preventive Analgesia 348 8.2.2 Analgesic Activity of Ibuprofen Isomers 349 8.2.3 Ibuprofen-Containing Combinations 350 8.2.4 Ibuprofen Formulations 354 8.3 Effects on Oedema 355 8.4 Interactions with Plasma β-Endorphin 356 8.5 Use for Chronic Temporomandibular Pain 356 8.6 Recommendations for the Use of Ibuprofen in Dentistry 358 References 359 9 Gastrointestinal Adverse Reactions from Ibuprofen 363Kim D. Rainsford and Ingvar Bjarnason Summary 363 9.1 Background and Introduction 364 9.2 Current Status Concerning NSAID Ulceration 365 9.2.1 Morbidity and Mortality 366 9.3 Occurrence of Ulcers and Complications 369 9.3.1 Epidemiological Studies 369 9.3.2 Large-Scale Mega Trials 376 9.4 Clinical Investigations on Comparative GI Effects of Ibuprofen 378 9.4.1 Early Symptom-Based Studies in GI]Intolerant Subjects 378 9.4.2 Procedures for Assessing GI Injury 379 9.4.3 Upper GI Endoscopy 380 9.4.4 NSAID-Enteropathy: Capsule and Device Assisted Intestinal Endoscopy and Other Techniques 381 9.4.5 Radiochromium [51Cr]-Labelled Red Cell GI Blood Loss 389 9.4.6 Intragastric and Occult Blood Loss and Reduced Haemoglobin 394 9.5 Clinically-Relevant Pathogenesis of NSAID-Associated GI Injury 395 9.5.1 Factors Affecting NSAID-Induced Gastroduodenal Injury 395 9.5.2 Influence of Gastric Acidity 397 9.5.3 Physicochemical Associations, Topical versus Systemic Actions of NSAIDs, Cyclo]oxygenases and Reduced Prostanoids 399 9.5.4 Effects of NSAIDs on Gastric pH and Acid Secretion 402 9.6 Procedures for Reducing GI Symptoms 404 9.6.1 Ibuprofen Formulations 404 9.6.2 Effects of Food or Drinks 406 9.6.3 Mucus Protection Strategies 409 9.6.4 Anti-ulcer Agents 410 9.7 Overall Assessment of GI Safety of Ibuprofen 412 References 412 10 Hepatorenal Effects of Ibuprofen Compared with other NSAIDs and Paracetamol 432Kim D. Rainsford 10.1 Introduction 432 10.2 Hepatorenal Syndromes 433 10.3 NSAID, Analgesic and DMARD-Induced Liver Injury 433 10.3.1 Historical Associations of NSAIDs with Liver Toxicity 433 10.3.2 Awareness of Liver Reactions with Modern NSAIDs 434 10.3.3 Simultaneous Use of Potentially Hepatotoxic Medications 439 10.4 Renal Adverse Reactions Form NSAIDs and Analgesics 442 10.4.1 Renal Adverse Reactions from Ibuprofen 444 10.5 Conclusions 446 References 446 11 Adverse Drug Reactions Attributed to Ibuprofen: Effects Other Than Gastrointestinal 452L.J. Miwa, M. Manenos and Judith K. Jones 11.1 Introduction 452 11.2 Allergy and Hypersensitivity 453 11.2.1 Points to Consider when Evaluating Allergy-Type Reactions to NSAIDs 453 11.2.2 Epidemiology of Allergy or Hypersensitivity with NSAIDs 454 11.3 Adverse Dermatological Effects 457 11.4 Hepatotoxicity 458 11.5 Haematological Adverse Effects 465 11.5.1 Neutropenia, agranulocytosis and aplastic anaemia 465 11.5.2 Other Blood Disorders 466 11.6 Renal Adverse Effects 466 11.7 Cardiovascular Adverse Effects 470 11.8 Adverse Effects on Reproduction 477 11.8.1 Animal Studies of Teratogenic and Reproductive Effects 477 11.8.2 Reports of Teratogenic Effects in Humans 478 11.8.3 Perinatal Adverse Effects Associated with Therapeutic Use 479 11.8.4 Other Reproductive Effects 480 11.9 Endocrine and Metabolic Adverse Effects 480 11.10 Central Nervous System Effects 480 11.10.1 General CNS Effects 480 11.10.2 Aseptic Meningitis 481 11.10.3 Cognitive Dysfunction 481 11.10.4 Psychiatric Adverse Effects 481 11.11 Ocular Adverse Effects 481 11.12 Infection-Related Adverse Event 482 11.13 Drug Interactions 482 11.13.1 NSAID–Anti-hypertensive Interactions 483 11.13.2 NSAID–Diuretic Interactions 484 11.13.3 NSAID–β-Adrenergic Blocker Interactions 484 11.13.4 NSAID–Angiotensin-Converting Enzyme Inhibitor Interactions 484 11.13.5 NSAID–Oral Anti-coagulant Interactions 484 11.13.6 NSAID–Aminoglycoside Interactions 485 11.13.7 NSAID–Oral Hypoglycemic Interactions 485 11.13.8 NSAID–Cyclosporin Interactions 485 11.13.9 NSAID–Lithium Interactions 485 11.13.10 NSAID–Methotrexate Interactions 485 11.13.11 Ibuprofen–Aspirin Interactions 486 11.14 Future Needs 486 References 487 12 Human Toxicity of Ibuprofen 500Glyn Volans Summary 500 12.1 Introduction 500 12.2 Mechanism of Toxicity in Overdosage 501 12.3 Epidemiological Reviews of the Effects of Ibuprofen in Overdosage 501 12.4 Reports of Deaths after Ibuprofen Overdose 502 12.5 Dose–Response and Toxicokinetics 502 12.6 Gastrointestinal Effects 508 12.7 Renal Effects 509 12.7.1 Cases of Massive Overdose 509 12.7.2 Cases Affected by Additional Factors 509 12.8 Metabolic Effects 510 12.9 Central Nervous System (CNS) Effects 511 12.10 Cardiovascular Effects 511 12.11 Respiratory Effects 512 12.12 Haematological Effects 512 12.13 Skin Reactions 512 12.14 Ibuprofen Toxicity in Children 512 12.15 Ibuprofen in Pregnancy and Breast Feeding 513 12.16 Chronic Abuse of Ibuprofen 513 12.17 Conclusion 514 12.17.1 Management of Ibuprofen Overdosage 514 12.17.2 Continuing Surveillance 515 12.17.3 Comparative Human Toxicity – Ibuprofen versus Other NSAIDs and Non]opioid Analgesics 516 References 516 13 Ibuprofen in the Prevention and Therapy of Cancer 520Randall E. Harris Summary 520 13.1 Introduction and Background 521 13.2 Ibuprofen, COX-1 and COX-2 522 13.3 COX-2 and the Inflammogenesis of Cancer 522 13.4 Preclinical Efficacy Studies of Ibuprofen and Cancer 523 13.4.1 Preclinical Efficacy Study of Ibuprofen Therapy for Breast Cancer 523 13.4.2 Preclinical Efficacy Study of Ibuprofen versus Retinoic Acid for the Prevention of Breast Cancer 523 13.4.3 Preclinical Efficacy Study of Celecoxib versus Ibuprofen for the Prevention of Breast Cancer 524 13.4.4 Other Animal Studies of NSAIDs and Cancer 524 13.5 Human Epidemiologic Studies of Ibuprofen for the Prevention of Cancers of the Breast, Colon, Prostate and Lung 525 13.5.1 Methods of Analysis 526 13.5.2 Comparative Results for Ibuprofen and Aspirin from Eepidemiologic Studies of Cancers of the Breast, Colon, Prostate and Lung 526 13.5.3 Comparison of Ibuprofen, Aspirin and Selective COX]2 Inhibitors in Cancer Prevention 527 13.5.4 Meta-analyses of Epidemiologic Studies of NSAIDs for Cancer Prevention 528 13.5.5 Discussion of Meta-analyses of NSAIDs and Cancer 530 13.6 Therapeutic Studies of Non-selective COX-2 Inhibitors for Human Cancer 531 13.7 COX-2 and the Inflammogenesis of Cancer 533 13.7.1 COX-2 Blockade of Molecular Carcinogenesis 533 13.7.2 Role of COX-1 in Carcinogenesis 534 13.7.3 Other Molecular Targets of NSAIDs 535 13.8 Safety Profile of Ibuprofen 535 13.8.1 COX-1 and COX-2 Isoforms 535 13.8.2 Gastrointestinal and Renal Effects of Ibuprofen 535 13.8.3 Ibuprofen and Cardiovascular Disease 536 13.9 Future Perspectives for Cyclooxygenase Inhibitors in Cancer Chemoprevention 536 References 537 14 Ibuprofen in Prevention of Neurodegenerative Diseases 549Kim D. Rainsford Summary 549 14.1 Introduction 550 14.2 Pathogenesis of AD 550 14.3 Early Clinical Observations of Effects of NSAIDs in AD 551 14.4 Cellular and Molecular Effects of Ibuprofen in AD 555 14.4.1 Actions of Ibuprofen in Rodent AD Models 556 14.4.2 In Vitro Effects and Molecular Actions of Ibuprofen in AD 558 14.4.3 Conclusions 559 14.5 Ibuprofen in Parkinson’s Disease 559 14.5.1 Effects of Ibuprofen in Models of PD 561 14.6 Other Neuroprotective Effects of Ibuprofen 561 14.7 Conclusions 562 References 562 Appendix A Some Proprietary Brands and Preparations of Ibuprofen Available Worldwide 573Kim D. Rainsford Appendix B References to Analytical Methods for Determination ofIbuprofen in Biological Fluids, Principally Plasma 583Kim D. Rainsford Index 000
£136.95
John Wiley and Sons Ltd Male Sexual Dysfunction
Book SynopsisSexual dysfunction affects men of all ages and incidence rates are expected to double by 2025 resulting in a major health burden. Though normal sexual function is an important aspect of health and well-being, sadly, this common condition still carries an associated stigma. As a result, affected men are often reluctant to approach their doctor and, instead, may live for many years with sexual dysfunction, often to the detriment of their personal lives. Male Sexual Dysfunction: A Clinical Guide covers all the common problems encountered by the clinician in this rapidly expanding and developing field. With full color throughout, this easy to read guide provides a comprehensive and systematic approach to patient management. Packed with key features, every chapter will contain flow diagrams and algorithms, key points, clinical pearls, ?what to avoid? boxes, and numerous tables, graphs and photographs . This book provides: Comprehensive focus on the core clinTable of ContentsList of contributors, vii Foreword, x 1 Epidemiology of male sexual dysfunction 1 Raanan Tal 2 Physiology of ejaculation 8 Marcel D. Waldinger 3 Physiology of penile erection 14 Uwais B. Zaid, Xiaoyu Zhang, and Tom F. Lue 4 Anatomy of penile erection 22 Lindsay Yuh and Alan Shindel 5 Endocrinology of male sexual dysfunction 30 Salim Janmohamed and Pierre‐Marc G. Bouloux 6 Pharmacology of drugs used for the treatment of erectile dysfunction 48 Ian Eardley 7 Pharmacology of drugs used in premature ejaculation 56 Michael Grant Wyllie 8 Cardiovascular risk and erectile dysfunction 62 Graham Jackson 9 The evaluation of the patient with erectile dysfunction 69 Geoffrey Hackett 10 Endocrinological investigation of men with erectile dysfunction 79 Giovanni Corona, Linda Vignozzi, and Mario Maggi 11 Duplex ultrasonography and its role in the assessment of male sexual dysfunction 91 Conrad von Stempel and Miles Walkden 12 MRI in men with sexual dysfunction 102 Alex Kirkham 13 The metabolic syndrome and ED 109 Mark Paulos and Martin Miner 14 Psychological assessment of patients with ED 120 Catherine Benedict and Christian J. Nelson 15 Nocturnal penile tumescence study 129 Chi‐Ying Li, Stephen Larsen, and Tet Yap 16 Psychosexual therapy for male sexual dysfunction 133 Angela Gregory 17 Treatment of premature ejaculation and ejaculatory disorders 143 Michael Kirby 18 Erectile dysfunction and infertility 152 Vikram Soni, Alexander W. Pastuszak, and Mohit Khera 19 Drug therapy for erectile dysfunction 172 Francisco J. Garcia, Eric Chung, and Gerald Brock 20 Priapism 194 Varun Sahdev, David Ralph, and Asif Muneer 21 Management of erectile dysfunction after pelvic surgery 203 Kelly A. Chiles and John P. Mulhall 22 Management of erectile dysfunction in men with diabetes 210 Marc Lucky, Suks Minhas, and Jas Kalsi 23 Management of erectile dysfunction in neurological patients 220 Katarina Ivana Tudor and Jalesh N. Panicker 24 Non‐surgical therapy for Peyronie’s disease 229 Rowland Rees and Victoria Dawson 25 Micropenis and penile dysmorphobia: diagnosis, management, outcomes, and future developments in the field 236 Oliver Kayes, Lizzie Chandra, and Andrew Yates 26 Surgical treatment of Peyronie’s disease 246 Ates Kadioglu and Emre Salabas 27 Penile implant surgery 258 Patrick Selph and Culley Carson 28 Vascular surgery for erectile dysfunction 270 Ronny B.W. Tan and Wayne J.G. Hellstrom 29 Penile cancer 276 Majid Shabbir and Paul K. Hegarty 30 Penile reconstruction and trauma 283 C.J. Shukla and Suks Minhas 31 Disorders of sex development 294 Dan Wood 32 Sexual dysfunction and prostate cancer therapy 302 Ashley Ridout, Mark Emberton, and Caroline Moore 33 Assessment and management of the male to female transgender patient 314 Tina G. Rashid, Phillip Thomas, and James Bellringer Index 323
£113.95
John Wiley and Sons Ltd Early Years Nutrition and Healthy Weight
Book SynopsisEarly Years Nutrition and Healthy Weight focuses on the early years of childhood as a key period in which eating and exercise habits are formed. Combining current evidence with practical advice, an international group of health specialists advise on the avoidance and management of childhood obesity.Table of ContentsContributors, viii Foreword, x Acknowledgments, xii 1 Importance of good health and nutrition before and during pregnancy, 1Catherine R. Hankey 2 Nutrition and health in the early years, 14Judy More 3 Defining and measuring childhood obesity, 30Charlotte M. Wright 4 Early life risk factors for childhood obesity, 40John J. Reilly and Adrienne R. Hughes 5 Early physical activity and sedentary behaviours, 46Anthony D. Okely and Xanne Janssen 6 Talking about weight with families, 59Paul Chadwick and Helen Croker 7 Parenting strategies for healthy weight in childhood, 71Clare Collins, Tracy Burrows and Kerith Duncanson 8 Pre-school prevention interventions, 81Pinki Sahota 9 Contribution of food provision in primary schools to the prevention of childhood obesity, 91Ethan A. Bergman 10 Early clinical interventions and outcomes, 100Louise A. Baur Index, 112
£42.83
John Wiley & Sons Inc Neonatal Formulary
Book SynopsisNeonatal Formulary is a unique publication that provides comprehensive guidance on the safe use of all the drugs prescribed during pregnancy and commonly given to babies during labour, delivery, and the first year of life. This new editionprovides improved and detailed coverage of the many drugs that are given to women during pregnancy and during lactation where the baby''s welfare must be borne in mind as well as that of the mother. Thus the whole ''pregnancy through to parenthood'' journey is treated as a continuous event with information about drug use and the effects of drugs at all stages of the development from fetus to infant. Containing far more detail than is available in the British National Formulary for Children and with a companion website featuring updates related to specific drugs and dosing, Neonatal Formulary is an essential guide for neonatologists, neonatal nurses, hospital pharmacists, obstetric staff, advanced nurse practitioners and Table of ContentsIntroduction viii Important advisory statement xi Further reading xiii Acknowledgements xv Part 1: Drug prescribing and drug administration 1 Terms, symbols, abbreviations and units 3 Drug storage and administration 5 Drugs and the body 12 Drugs and the law 14 The care and use of intravascular lines 17 Minimising IV infusion and other drug hazards 24 Patient safety initiatives 27 Writing a hospital prescription 30 Adverse reactions and overtreatment 33 Maternal drug abuse 36 Renal failure 39 Body weight and surface area 42 Effects of therapeutic hypothermia on medications 44 Useful websites 48 Part 2: Drug monographs 55 Part 3: Maternal medication and its effect on the baby 555 Introduction 556 Further reading 558 Maternal medication and the baby 560 Index 608
£68.95
John Wiley and Sons Ltd Handbook for Clinical Trials of Imaging and
Book SynopsisThis book focuses on educating radiologists, radiation oncologists and others interested in imaging research about how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers.Table of ContentsContributors, vi Chapter 1 Imaging technology assessment, 1Pari V. Pandharipande and G. Scott Gazelle Chapter 2 Clinical trials of therapy, 10Sayeh Lavasani, Anthony F. Shields and Ali Mahinbakht Chapter 3 Clinical trials of image]guided interventions including radiotherapy studies, 29Gary S. Dorfman and Stephen M. Hahn Chapter 4 Imaging as a predictor of therapeutic response, 57David A. Mankoff and Anthony F. Shields Chapter 5 Screening trials and design, 76Janie M. Lee, Constance D. Lehman and Diana L. Miglioretti Chapter 6 Practicalities of running a clinical trial, 91Michael T. Lu, Elizabeth C. Adami and Udo Hoffmann Chapter 7 Statistical issues in study design, 103Nancy A. Obuchowski Chapter 8 Introduction to biostatistical methods, 126Diana L. Miglioretti, Todd A. Alonzo and Nancy A. Obuchowski Chapter 9 Methods for studies of diagnostic tests, 147Jeffrey D. Blume Chapter 10 Methods for quantitative imaging biomarker studies, 170Alicia Y. Toledano and Nancy A. Obuchowski Chapter 11 Introduction to cost]effectiveness analysis in clinical trials, 189Ruth C. Carlos and G. Scott Gazelle Index, 208
£82.60
John Wiley and Sons Ltd Blandys Urology
Book SynopsisBlandy''s Urology, 3rd edition is set to become a classic in its field, the latest edition of one of the most well-loved general urology textbooks for urologists and surgeons alike, successfully combining both general urology and urologic surgery. Its key strength is the unique Blandy way' of describing urological diseases and their management, consisting of: clear, straightforward, uncomplicated descriptions of disease/conditions, includinghundreds ofclinical photos an abundance of outstanding drawn surgical diagrams to illustrate best technique in the operating theatre a focus on the most commonly seen problems in the clinic organization of each topic underanatomical headings Especially loved by urology and surgery trainees for its straightforward approach to the speciality and as a preparation for speciality urology exams, consultants and specialists also value it as a handy refresher tool.Table of ContentsPreface xxxvii List of Contributors xxxix Part I 1 1 Armaments in Urology 3Shibs Datta 1.1 Principles of Urological Technology 4 1.2 Wound Healing in the Urinary Tract 19 1.3 Simulation in Urology 27 2 Principles of Medical Statistics 39Julie Morris 2.1 Introduction 39 2.2 Descriptive Statistics 39 2.3 Confidence Intervals 41 2.4 Significance Tests 42 2.5 Relationships between Variables 44 2.6 Diagnostic Tests 45 2.7 Study Design 46 2.8 Number Needed to Treat 47 2.9 Systematic Reviews and Meta‐Analysis 47 3 Embryology for the Urologist 49Allan Johnston, Maike F. Eylert, Tarik Amer, and Omar M. Aboumarzouk 3.1 Historical Consideration 50 3.2 Introduction 50 3.3 Embryology of the Kidneys and Ureters 50 3.4 Embryology of the Bladder 57 3.5 Embryology of the Indifferent Genital System 60 3.6 Embryology of the Male Genital System 61 3.7 Embryology of the Prostate 67 3.8 Embryology of the Penis and Urethra 68 3.9 Neuter State 70 3.10 Embryology of the Female Genital System 70 3.11 Embryology of the Adrenal Gland 71 References 4 Principles of Urologic Oncology 75Oliver W. Hakenberg 4.1 The Scope of Urologic Oncology 75 4.2 Carcinogenesis 75 4.3 Molecular Biology of Cancer Growth 79 4.4 Tumour‐ Promoting Inflammation 81 4.5 Reprogramming Energy Metabolism 81 4.6 Evading Immune Destruction 82 4.7 The Tumour Microenvironment 82 4.8 The Rate of Cancer Growth 82 4.9 Principles of Treatment 82 4.10 Oncologic Surgery 84 Part II 91 5 Kidney and Ureter Anatomy 93Hiro Ishii, Omar M. Aboumarzouk, and Hendrik Van Poppel 5.1 Comparative Anatomy 94 5.2 Renal Fasciae 96 5.3 Macroscopic Appearances 96 5.4 Arterial Supply 96 5.5 Renal Veins 98 5.6 Common Vascular and Anatomic Variations 99 5.7 Lymphatics 99 5.8 Innervation of the Kidney 99 6 Kidney and Ureter Physiology 107Motaz ElMahdy Hassan and Mohamed Ismail 6.1 Glomerular Filtration Rate 107 6.2 Renal Tubules 109 6.3 Hormonal Function of the Kidney 110 6.4 Special Disorders of Renal Tubules 111 6.5 Acid–Base Metabolism 111 6.6 Obstructive Uropathy 112 6.7 Ureteric Physiology 113 6.8 Whitaker Test 114 7 Renal Failure 117Pramod Nagaraja and Farid Ghalli 7.1 Acute Kidney Injury 117 7.2 Chronic Kidney Disease 120 7.3 Dialysis 123 8 Renal Transplant 127Oliver W. Hakenberg 8.1 The Patients and the Kidneys 128 8.2 Technique of Removal of Donor Kidneys 130 8.3 Immunology of Organ Transplantation 137 8.4 Graft Rejection 139 8.5 Immunosuppression 141 9 Kidney and Ureter: Congenital and Acquired Anomalies 145Alberto Mantovani, Jane Hendry, and Pankaj Mishra 9.1 Introduction 145 9.2 Congenital Abnormalities of the Kidney 145 9.3 Congenital Abnormalities of the PUJ 153 10 Hydronephrosis 165Maitrey Darrad, Ameet Gupta, and Nick Rukin 10.1 Definition 165 10.2 Incidence 165 10.3 Pathophysiology 166 10.4 Diagnostic Imaging 169 10.5 Complications of Hydronephrosis 171 10.6 Management (General Principles) 171 10.7 Perinatal Hydronephrosis 171 10.8 Pelviureteric Junction Obstruction 172 10.9 Retrocaval Ureter 181 10.10 Duplication Anomalies, Ectopic Ureter, and Ureteroceles 181 10.11 VUR 183 10.12 Megaureter 185 10.13 Ureteral Strictures 185 11 Kidney and Ureter Trauma 189Sarfraz Ahmad and Omar M. Aboumarzouk 11.1 Kidney Injuries 189 11.2 Ureteral Injuries 200 12 Kidney and Ureter Inflammation 209Ameet Gupta and Krishna Narahari 12.1 Medical Inflammatory Conditions of the Kidney 209 12.2 Acute Surgical Inflammatory Conditions of the Kidney 211 12.3 Chronic Surgical Inflammatory Conditions of the Kidney 218 12.4 Other Inflammatory Conditions of the Kidney 223 12.5 Inflammatory Conditions of the Ureters 228 13 Kidney and Ureter Neoplasm 237Jane Hendry, Bhavan P. Rai, Alan S. McNeill, Ghulam Nabi, Jens-Uwe Stolzenburg, Khaver Qureshi, Nkem Umez‐Eronini, Grenville Oades, and Omar M. Aboumarzouk 13.1 Kidney Neoplasms 238 13.2 Benign Renal Masses 258 13.3 Ureter and Renal Pelvis Neoplasms 261 14 Kidney and Ureter Calculi 277Omar M. Aboumarzouk, Paul Cook, Olivier Traxer, Palle J.S. Osther, Luca Villa, Jonathan Cloutier, Helene Jung, Kim H. Andreassen, and Bhaskar K. Somani 14.1 Epidemiology 277 14.2 Pathophysiology 277 14.3 Formation of Calculi in the Kidney 278 14.4 Common Types of Urinary Stones 279 14.5 Clinical Features 281 14.6 Complications of Stones 281 14.7 Investigations 282 14.8 Investigations for Metabolic Stone Disease 288 14.9 Medical Management of Stones 289 14.10 Surgery for Stones 291 15 Kidney and Ureter Vascular Disorders 321Abdullah Zreik and Omar M. Aboumarzouk 15.1 Congenital Anomalies of the Renal Vessels 321 15.2 Renal Artery Disorders 322 15.3 Disorders of the Renal Veins 328 16 The Adrenal Glands 331Michael Stechman and David Scott Coombes 16.1 Principles of Endocrine Surgery 331 16.2 Anatomy 332 16.3 Physiology 333 16.4 Pathology 334 16.5 Pathology of the Adrenal Medulla 340 16.6 Congenital Disorders of the Adrenals 346 16.7 Trauma 346 16.8 Inflammation 346 Part III 349 17 Bladder and Urethra Structure and Function 351Maike F. Eylert and Arjun K. Nambiar 17.1 Anatomy 351 17.2 Physiology 355 18 Bladder Congenital Anomalies 359Katerina Prodromou and Pankaj Mishra 18.1 Embryology 359 18.2 Exstrophy‐ Epispadias Complex 359 18.3 Urachal Anomalies 368 18.4 Bladder Diverticula 370 18.5 Disorders of Development of the Sacrum 371 18.6 UTI in Children 371 19 Bladder Trauma 383Abdullah Zreik, Ahmed Mahrous, and Omar M. Aboumarzouk 19.1 Bladder Injuries 383 20 Bladder Inflammation 391Ameet Gupta, Anna Manwaring, and Krishna Narahari 20.1 Introduction and Definitions 391 20.2 Acute Cystitis or Lower UTI 392 20.3 Chronic Interstitial Cystitis and Bladder Pain Syndrome 400 20.4 Tuberculosis 400 20.5 Parasitic Infections 400 20.6 Amoebiasis 405 20.7 Worm Infestations 406 20.8 Catfish 406 21 Bladder Neoplasm 409Kawa Omar, Nawal Shamim Khan, and Muhammad Shamim Khan 21.1 Bladder Neoplasm 410 21.2 Field Biopsies 417 21.3 Pathology 417 21.4 Malignant Tumours of the Bladder 417 21.5 Grading of Transitional Cell Carcinoma 422 21.6 Staging of Bladder Tumours 422 21.7 Risk Stratification after Transurethral Resection of Bladder Tumour 422 21.8 Treatment of Transitional Cell Carcinoma 422 21.9 Muscle‐ Invasive Bladder Cancer 427 21.10 Recurrence and Follow‐up of MIBC 435 21.11 Management of Locally Advanced MIBC (T3b/T4) and Metastatic Disease (N1 or M1) 435 21.12 Bladder Cancer Variants 437 22 Urinary Diversion 447Kawa Omar, Nawal Shamim Khan, Shahrokh F. Shariat, Johannes Alfred Witjes, and Muhammad Shamim Khan 22.1 Urinary Diversions 448 22.2 Bladder Urinary Diversion 449 22.3 Functional Follow‐Up 461 22.4 Quality of Life Urinary Diversion after Cystectomy 461 23 Bladder Disorder of Function 465Arjun K. Nambiar, Maike F. Eylert, Lisette A ‘t Hoen, and Bertil F.M. Blok 23.1 Introduction 465 23.2 Investigating Bladder Function 468 23.3 Disorders of Function 476 23.4 Urethral Disorders 489 24 Fistulae and Sinuses 499Jenny Jones and Omar M. Aboumarzouk 24.1 Principles and Definitions 499 24.2 Pathophysiology 499 24.3 General Complications 500 24.4 Organ‐Specific Fistulae 500 Part IV 509 25 Prostate Structure and Function 511Adam Cox, Matthew Jefferies, and Raj Persad 25.1 Comparative Anatomy 511 25.2 Maturation of the Prostate 511 25.3 Anatomy of the Prostate 513 25.4 Prostate Physiology 517 26 Prostate Inflammation 523Mark J. Salji, Truls E. Bjerklund Johansen, and Hing Y. Leung 26.1 Classification of Prostatitis 523 26.2 Investigations 525 26.3 Imaging 525 26.4 Serum Prostate Specific Antigen 526 26.5 Histology 526 26.6 Treatment Options 526 26.7 Upoint Phenotypic Classification of CP/CPPS 527 26.8 Surgical Options 527 26.9 Heat Therapies 527 26.10 Prostate Tuberculosis 528 26.11 Summary 528 27 Prostate Benign Prostatic Hyperplasia 531Daniel W. Good, Bashar Nahas, Simon Phipps, Rick Popert, Jens‐Uwe Stolzenburg, and Stuart Alan S. McNeill 27.1 Nomenclature 532 27.2 Aetiology 532 27.3 Pathology of BPH 534 27.4 Complications of BPH 535 27.5 Epidemiology and Natural History of BPH 538 27.6 Investigations 539 27.7 Management 541 27.8 Surgical Management 547 28 Prostate Neoplasm 563Mark J. Salji, Imran Ahmad, Sarah Slater, Fat‐Wui Poon, Abdulla Alhasso, Nadja V. Melquiot, Holly Bekarma, Jane Hendry, and Hing Y. Leung 28.1 Epidemiology 563 28.2 Aetiology 564 28.3 Clinical Features 565 28.4 Prognosis 566 28.5 Investigations 566 28.6 Pathology, Histopathology, and Molecular Pathology 573 28.7 Management, Treatments, and Patient Selection 577 28.8 Androgen‐Deprivation Therapy 587 28.9 Castration‐Resistant Prostate Cancer 591 28.10 The Role of TURP for Voiding Symptoms Associated with PCa 593 28.11 Controversies, Cutting‐Edge Developments, and Hot Topics 594 Part V 611 29 Penis and Urethra Structure and Penis 613Ayman Younis and Christopher Harding 29.1 Anatomy and Physiology 613 29.2 The Penis 613 29.3 The Scrotum 617 29.4 The Urethra 617 29.5 Erection 619 29.6 Function of the Scrotum 622 30 Penis and Urethra and Prostate Congenital Anomalies 623Anand Upasani, Divyesh Desai, Imran Mushtaq, and Pankaj Mishra 30.1 Foreskin 623 30.2 Hypospadias 628 30.3 Primary Epispadias 632 30.4 Posterior Urethral Valves 635 30.5 Prostatic Utricle 639 30.6 Syringocele 639 30.7 Anterior Urethral Valves 640 30.8 Urethral Duplication 641 30.9 Urethral Anomalies in Anorectal Malformations 642 30.10 Interesting Terminologies 645 31 Penis and Urethra Trauma 651Ayman Younis and Trevor J. Dorkin 31.1 Penis and Scrotum 651 31.2 Urethral Trauma 653 32 Penis and Urethra Inflammation 663Nick Watkin and Asheesh Kaul 32.1 Urethral Inflammation 663 32.2 Penile Inflammation 664 32.3 Other Urethro‐Peno‐Scrotal Pathologies 666 32.4 Stricture Disease of the Urethra 668 32.5 Pelvic Fracture Urethral Injury 676 33 Penis and Urethra Neoplasm 687Tom Swallow and Duncan Summerton 33.1 Penile Neoplasm 687 33.2 Lymph Node Disease 695 33.3 Urethral Neoplasm 699 34 Penis and Urethra Disorders of Function 705Sarfraz Ahmad and Nick Watkin 34.1 Erectile Dysfunction 705 34.2 Premature Ejaculation 712 34.3 Retrograde Ejaculation 715 34.4 Anejaculation 715 34.5 Priapism 716 34.6 Peyronie Disease 719 34.7 Late Onset Hypogonadism 722 Part VI 729 35 Testes Structure and Function 731Tusshyenthan Seevagan, Stephen Hulligan, Jaspal Phull, and Omar M. Aboumarzouk 35.1 Comparative Anatomy 731 35.2 Topographical Anatomy 732 35.3 Blood Supply and Lymphatic Drainage 733 35.4 Epididymis 734 35.5 Vas Deferens 735 35.6 Seminal Vesicle 736 35.7 Verumontanum 736 35.8 Spermatic Cord 736 35.9 Testicular Physiology 736 36 Testes Congenital and Childhood Anomalies 741Eleni Papageorgiou, Abraham Cherian, and Pankaj Mishra 36.1 Congenital Anomalies of the Testis 741 36.2 Inguinoscrotal Masses 749 36.3 The Acute Scrotum 753 37 Testes Trauma and Inflammation 759Senthy Sellaturay, Kamran Ahmed, Muhammad Shamim Khan, and Majed Shabbir 37.1 Testicular Trauma 760 37.2 Inflammatory Diseases of the Testicle 761 37.3 Chronic Inflammation 763 37.4 Treatment 764 38 Testes Benign Swelling 769Jasper Bondad, Piotr L. Chlosta, and Omar M. Aboumarzouk 38.1 Hydrocele 769 38.2 Epididymal Cyst 773 38.3 Benign Testicular Cyst 774 38.4 Testicular Torsion 774 38.5 Polyorchidism 775 38.6 Varicocele 776 38.7 Orchialgia 778 38.8 Nux Amatoris 778 39 Testes Neoplasm 783Michelle Carey, Omar M. Aboumarzouk, and Johannes Alfred Witjes 39.1 History 784 39.2 Incidence 784 39.3 Basic Embryology 784 39.4 Aetiology and Risk Factors 784 39.5 Clinical Features 785 39.6 Diagnosis 785 39.7 Staging 791 39.8 Method of Spread 791 39.9 Prognosis 793 39.10 Treatment 793 39.11 Nongerm Cell Tumours 797 39.12 Tumours Containing Both Germ Cell and Sex Cord or Gonadal Stromal Elements: Gonadoblastoma 798 39.13 Other Tumours of the Testis 798 39.14 Tumours of the Paratesticular Structures 798 40 Male Infertility 803Amr Abdel Raheem, Rowland Rees, and David Ralph 40.1 Incidence 803 40.2 Definitions 803 40.3 History and Examination 804 40.4 Aetiology 804 40.5 Investigations for Male Infertility 807 40.6 Testis Biopsy 809 40.7 Treatment of Male Infertility 811 40.8 Assisted Conception Techniques 812 40.9 Varicocele Repair 812 40.10 Medical Treatment of Male Infertility 813 41 Vasectomy and Seminal Vesicle Disorders 817Omar M. Aboumarzouk, Bryan Jenkins, and Piotr L. Chlosta 41.1 Seminal Vesicles 818 41.2 Vasectomy 820 Index 825
£147.20
John Wiley and Sons Ltd Ureteric Stenting
Book SynopsisThe only book dedicated to this important area of urology, Ureteric Stenting comprehensively reviews the entire topic, providing highly specialized advice to enable outstanding clinical management of patients.Table of ContentsList of Contributors vii Foreword x Preface xi 1 Anatomy of the Human Ureter 1 2 Anatomic Variations of the Ureter 10 3 The Pathophysiology of Upper Tract Obstruction 16 4 Physiology of the Human Ureter 29 5 Etiology of Ureteric Obstruction 48 6 The Role of the Interventional Radiologist in Managing Ureteric Obstruction 55 7 Emergency Management of Ureteric Obstruction 67 8 The History and Evolution of Ureteral Stents 75 9 Ureteral Stent Materials: Past, Present, and Future 83 10 Physical Characteristics of Stents 91 11 Coated and Drug-Eluting Stents 102 12 Coated and Drug-Eluting Ureteric Stents 110 13 Ureteric Stents: A Perspective from the Developing World 118 14 Ethical Issues in Ureteric Stenting 130 15 Equipment and Technical Considerations During Ureteric Stenting 136 16 Extra-Anatomic Stent Urinary Bypass 149 17 Detour Extra-Anatomical Ureteric Stent 161 18 Tandem Ureteral Stents 175 19 Biodegradable Ureteric Stents 182 20 Metallic Ureteric Stents 192 21 Removal of Ureteric Stents 203 22 Encrustation of Indwelling Urinary Devices 215 23 Stent Migration 227 24 Health-Related Quality of Life and Ureteric Stents 238 25 Evidence Base for Stenting 264 26 Robotic Ureteric Reconstruction 278 27 Indwelling Ureteric Stents – Health Economics Considerations 287 28 Ureteric Stents: The Future 296 Index 298
£108.25
John Wiley and Sons Ltd Handbook of Sports Medicine and Science
Book SynopsisA new volume in the Handbook of Sports Medicine and Science series from the International Olympic Committee, this volume Canoeing provides an accessible and comprehensive summary of the topic. Provides a concise, authoritative overview of the science, medicine and psycho-social aspects of canoeing Offers guidance on medical aspects unique to the training and coaching of canoe athletes The only book on this subject endorsed by the Medical Commission of the International Olympic Committee (IOC) and the International Canoe Federation (ICF) Written and edited by global thought leaders in sports medicine Table of ContentsList of Contributors, vi Foreword by ICF President, viii Foreword by IOC President, ix Preface, x 1 Introduction, 1Ian Mortimer and Don McKenzie 2 Biomechanics and equipment (sprint and slalom): a review of scientifically confirmed information, 12Barney Wainwright 3 The canoe/kayak athlete, 40Petra Lundström, Jorunn Sundgot Borgen, and Don McKenzie 4 Physiology of canoeing, 47Hans Rosdahl, Jose Calbet, A. William Sheel, and Robert Boushel 5 Sport psychology for canoe and kayak, 62Penny Werthner 6 Training for canoeing, 71Martin Hunter and Sylvain Curinier 7 Medical problems in canoeing and kayaking, 91Bo Berglund 8 Orthopaedic injuries in canoeing, 97Jozsef Dobos 9 Paracanoe, 106John Edwards, Anna Bjerkefors, Johanna Rosen,and Olga Tarassova 10 Exercise performance in masters canoeing athletes, 116Bo Berglund 11 Diversity in canoe sport, 122Don McKenzie and Kari‐Jean McKenzie Index, 133
£51.52
John Wiley and Sons Ltd Journal of Prosthodontics on Dental Implants
Book Synopsis* Peer-reviewed articles from the pages of the Journal of Prosthodontics * Mix of clinical reports, research articles, and reviews .Table of ContentsPreface ix Acknowledgments xi American College of Prosthodontists Position Statement on Dental Implants xiii PART I MANAGEMENT OF THE PARTIALLY EDENTULOUS PATIENT 1 ICK Classification System for Partially Edentulous Arches 3Sulieman S. Al-Johany and Carl Andres 2 A Systematic Approach to Definitive Planning and Designing Single and Multiple Unit Implant Abutments 10Sanjay Karunagaran, Sony Markose, Gregory Paprocki, and Russell Wicks 3 The Digital One-Abutment/One-Time Concept. A Clinical Report 21Florian Beuer, Julian Groesser, Josef Schweiger, Jeremias Hey, Jan-Frederik Güth, and Michael Stimmelmayr 4 Influence of Surgical and Prosthetic Techniques on Marginal Bone Loss around Titanium Implants. Part I: Immediate Loading in Fresh Extraction Sockets 27Antoine N. Berberi, Georges E. Tehini, Ziad F. Noujeim, Alexandre A. Khairallah, Moustafa N. Abousehlib, and Ziad A. Salameh 5 A Prospective Analysis of Immediate Provisionalization of Single Implants 35Thomas J. Balshi, Glenn J. Wolfinger, Daniel Wulc, and Stephen F. Balshi 6 Technique for Removing Cement between a Fixed Prosthesis and Its Substructure 41Abdullah S. Alsiyabi and David A. Felton 7 Immediate Loading of Dental Implants in the Esthetic Region Using Computer-Guided Implant Treatment Software and Stereolithographic Models for a Patient with Eating Disorders 45Daniel F. Galindo and Caesar C. Butura 8 A Screwless and Cementless Technique for the Restoration of Single-Tooth Implants: A Retrospective Cohort Study 52Rainier A. Urdaneta, Mauro Marincola, Meghan Weed, and Sung-Kiang Chuang PART II MANAGEMENT OF THE COMPLETELY EDENTULOUS PATIENT 9 Evidence-Based Criteria for Differential Treatment Planning of Implant Restorations for the Mandibular Edentulous Patient 67Steven J. Sadowsky and Peter W. Hansen 10 Mandibular Implant Overdenture Treatment: Consensus and Controversy 77David R. Burns 11 Evidence-Based Criteria for Differential Treatment Planning of Implant Restorations for the Maxillary Edentulous Patient 87Steven J. Sadowsky, Brian Fitzpatrick, and Donald A. Curtis 12 Relevant Anatomic and Biomechanical Studies for Implant Possibilities on the Atrophic Maxilla: Critical Appraisal and Literature Review 103Paulo Henrique Orlato Rossetti, Wellington Cardoso Bonachela, and Leylha Maria Nunes Rossetti 13 A Retrospective Analysis of 800 Brånemark System Implants Following the All-on-FourTM Protocol 114Thomas J. Balshi, Glenn J. Wolfinger, Robert W. Slauch, and Stephen F. Balshi 14 Practice-Based Evidence from 29-Year Outcome Analysis of Management of the Edentulous Jaw Using Osseointegrated Dental Implants 121Matilda Dhima, Vladimira Paulusova, Christine Lohse, Thomas J. Salinas, and Alan B. Carr 15 Double Full-Arch Versus Single Full-Arch, Four Implant-Supported Rehabilitations: A Retrospective, 5-Year Cohort Study 131Paulo Maló, Miguel De Araújo Nobre, Armando Lopes, and Rolando Rodrigues 16 The Influence of Rehabilitation Characteristics in the Incidence of Peri-Implant Pathology: A Case-Control Study 140Miguel Alexandre de Araújo Nobre and Paulo Maló 17 Concepts for Designing and Fabricating Metal Implant Frameworks for Hybrid Implant Prostheses 152Carl Drago and Kent Howell 18 Complications and Patient-Centered Outcomes with an Implant-Supported Monolithic Zirconia Fixed Dental Prosthesis: 1 Year Results 166Bryan Limmer, Anne E. Sanders, Glenn Reside, and Lyndon F. Cooper 19 Prosthetic Improvement of Pronounced Buccally Positioned Zygomatic Implants: A Clinical Report 177Ataís Bacchi, Mateus Bertolini Fernandes dos Santos, Marcele Jardim Pimentel, Mauro Antonio de Arruda Nóbilo, and Rafael Leonardo Xediek Consani PART III MANAGEMENT OF PATIENTS WITH MAXILLOFACIAL DEFECTS 20 Implant-Supported Facial Prostheses Provided by a Maxillofacial Unit in a U.K. Regional Hospital: Longevity and Patient Opinions 185S.M. Hooper, T. Westcott, P.L.L. Evans, A.P. Bocca, and D.C. Jagger 21 Immediate Obturator Stabilization Using Mini Dental Implants 192Gregory C. Bohle, William W. Mitcherling, John J. Mitcherling, Robert M. Johnson, and George C. Bohle III 22 Prosthetic Reconstruction of a Patient with an Acquired Nasal Defect Using Extraoral Implants and a CAD/CAM Copy-Milled Bar 197Carolina Vera, Carlos Barrero, William Shockley, Sandra Rothenberger, Glenn Minsley, and Carl Drago PART IV IN VITRO STUDIES 23 Influence of Implant/Abutment Connection on Stress Distribution to Implant-Surrounding Bone: A Finite Element Analysis 207Marcia Hanaoka, Sergio Alexandre Gehrke, Fabio Mardegan, César Roberto Gennari, Silvio Taschieri,Massimo Del Fabbro, and Stefano Corbella 24 An In Vitro Comparison of Fracture Load of Zirconia Custom Abutments with Internal Connection and Different Angulations and Thickness: Part I 215Abdalah Albosefi, Matthew Finkelman, and Roya Zandparsa 25 Surface Characteristics and Cell Adhesion: A Comparative Study of Four Commercial Dental Implants 221Ruohong Liu, Tianhua Lei, Vladimir Dusevich, Xiamei Yao, Ying Liu, Mary P. Walker, Yong Wang, and Ling Ye PART V GENERAL CONSIDERATIONS 26 Outcomes of Dental Implants in Osteoporotic Patients. A Literature Review 237Ioanna N. Tsolaki, Phoebus N. Madianos, and John A. Vrotsos 27 Updated Clinical Considerations for Dental Implant Therapy in Irradiated Head and Neck Cancer Patients 254Takako Imai Tanaka, Hsun-Liang Chan, David Ira Tindle, Mark MacEachern, and Tae-Ju Oh 28 Implant Treatment Record Form 263Tony Daher, Charles J. Goodacre, and Steven M. Morgano Index 267
£74.05
John Wiley and Sons Ltd Evidencebased Urology
Book SynopsisAn updated and revised resource to evidence-based urology information and a guide for clinical practice The revised and updated second edition of Evidence-Based Urology offers the most current information on the suitability of both medical and surgical treatment options for a broad spectrum of urological conditions based on the best evidence available. The text covers each of the main urologic areas in specific sections such as general urology, oncology, female urology, trauma/reconstruction, pediatric urology, etc. All the evidence presented is rated for quality using the respected GRADE framework. Throughout the text, the authors highlight the most patient-important, clinical questions likely to be encountered by urologists in day-to-day practice. A key title in the Evidence-Based series, this revised and expanded edition of Evidence-Based Urology contains new chapters on a variety of topics including: quality improvement, seminoma, nonseminomatoTrade Review"This is a valuable book for all who care for urological patients. Every provider should have a foundation in evidence-based medicine and be familiar with interpreting and applying clinical knowledge to patient care. This book helps readers to achieve both. It addresses today's most relevant clinical questions in a manner that enables readers to practice evidence-based medicine skills." - Doody's Book Review, April 2019Table of ContentsPart 1 Evidence‐based methodsPhilipp Dahm 1 Searching for evidence, 3Jeanette Buckingham 2 Clinical trials in urology, 19Charles D. Scales, Jr. and David F. Penson 3 Systematic reviews in urology, 25Philipp Dahm, Shahnaz Sultan, and Jae Hung Jung 4 Rating the quality of evidence and making recommendations, 39Philipp Dahm and Shahnaz Sultan 5 Evidence‐based clinical practice guidelinesin urology, 47Steven E. Canfield 6 Understanding concepts related to health economics in urology, 53Yair Lotan and Ryan Hutchinson 7 Quality improvement in urology, 59Nima Almassi and Howard B. Goldman Part 2 General urology and stone diseaseCharles D. Scales, Jr. 8 Antibiotic prophylaxis in urological surgery, 67Roderick Clark and Philippe Violette 9 Venous thromboembolism (VTE) prophylaxis, 89Vikram Narayan and Philipp Dahm 10 Operative safety, 103Elizabeth Timbrook Brown, Bryan J. Hill, and Roger R. Dmochowski 11 Prophylaxis and treatment of urinary tract infections in adults, 113Gabrielle J. Williams, Angela C. Webster, and Jonathan C. Craig 12 Medical management of stone disease, 133Timothy Y. Tseng and Glenn M. Preminger 13 Surgical management of renal stone disease, 159Justin M. Dersch, Brandon J. Otto, and Benjamin K. Canales 14 Surgical management of ureteral stone disease, 171Aaron H. Lay, Jay D. Raman, and Margaret S. Pearle Part 3 Pediatric urologyLuis H.P. Braga 15 Prenatal hydronephrosis, 187Shawn Dason and Luis H.P. Braga 16 Cryptorchidism, 197David I. Chu and Gregory E. Tasian 17 Vesicoureteral reflux disease, 209Ruiyang Jiang and Jonathan C. Routh 18 Circumcision, 217Roderick Clark and Sumit Dave 19 Nocturnal enuresis, 235Stacy T. Tanaka 20 Management of neurogenic bladder in children with spina bifida, 243Kourosh Afshar, Mir Sohail Fazeli, and Cyrus Chehroodi 21 Wilms tumor, 251Ruiyang Jiang and Jonathan C. Routh Part 4 Prostate cancerJulio M. Pow-Sang 22 Early detection and screening for prostate cancer, 257Pim J. van Leeuwen, Monique J. Roobol, and Phillip D. Stricker 23 Molecular markers for prostate cancer, 265Pranav Sharma, Eric Webb, and Julio M. Pow‐Sang 24 Imaging of the prostate, 279Matthew J. Watson, Francesca V. Mertan, Samuel Borofsky, Arvin K. George,Abhinav Sidana,Peter L. Choyke, Peter A. Pinto, and Baris Turkbey 25 Active surveillance for localized prostate cancer, 289Nathan Perlis and Laurence Klotz 26 Surgical management of prostate cancer,297Daniel A. Barocas and Michael S. Cookson 27 Radiation therapy for clinically localized prostate cancer, 317Michelle Echevarria, Peter A. Johnstone, and Kosj Yamoah 28 Management of metastatic prostate cancer, 331Michael S. Humeniuk, Tian Zhang, Megan A. McNamara,Sundhar Ramalingam, and Michael R. Harrison Part 5 Kidney and bladder cancerRodney H. Breau 29 Treatment of superficial bladder cancer, 349Alexander Kretschmer, Alexander Karl, and Badrinath R. Konety 30 Treatment of muscle‐invasive bladder cancer, 367Justin R. Gregg and Sam S. Chang 31 Management of upper tract urothelial carcinoma, 373Ilaria Lucca, Romain Mathieu, Tobias Klatte, and Shahrokh F. Shariat 32 Metastatic bladder cancer, 383Louise Harris, Caitlin Bowen, Satish Kumar, Bernadette Coles, and Malcolm Mason 33 Treatment of localized kidney cancer, 391Luke T. Lavallée, Frédérick Pouliot, and Rodney H. Breau 34 Treatment of metastatic kidney cancer, 399Przemyslaw W. Twardowski and Robert A. Figlin Part 6 Testis and penile cancerMichael C. Risk 35 Early‐stage (stage I) seminoma, 409Sia Daneshmand and Cory Hugen 36 Advanced (stage II and III) and recurrent seminoma, 417Peter C. Black and Christian Kollmannsberger 37 Early‐stage nonseminomatous germ‑cell tumor, 427Justin T. Matulay and James M. McKiernan 38 Advanced nonseminoma, 443Michael C. Risk and Clint Cary 39 Penile cancer, 457Oliver W. Hakenberg Part 7 Female urology, trauma, and reconstructionRoger R. Dmochowski 40 Medical management of urinary incontinence in women, 467Joshua A. Cohn, Elizabeth Timbrook Brown, W. Stuart Reynolds, Melissa R. Kaufman,Roger R. Dmochowski 41 Surgical treatment of female urinary incontinence, 479Alex Gomelsky 42 Diagnosis and treatment of overactive bladder, 489Nadir I. Osman, Altaf Mangera, and Christopher R. Chapple 43 Urethral stricture disease, 497Robert A. Goldfarb and Sean P. Elliott 44 Genitourinary trauma, 503Paul Chung and Bryan B. Voelzke Part 8 Male LUTS and sexual dysfunctionJohn M. Hollingsworth 45 Medical management of benign prostatic hyperplasia, 511Paholo G. Barboglio Romo and John M. Hollingsworth 46 Surgical management of lower urinary tract symptoms secondary to benign prostatic hypertrophy, 527Derek J. Lomas and Amy Krambeck 47 Chronic prostatitis/chronic pelvic pain syndrome (NIH category III), 539Giuseppe Magistro and Florian M.E. Wagenlehner 48 Management of erectile dysfunction, 545Hunter Wessells 49 Update on treatment of bladder pain syndrome: does anything work? 555Yahir Santiago‐Lastra, Ann Oldendorf, and J. Quentin Clemens 50 Male infertility, 561Bryan Hinck, Ashok Agarwal, Fnu Deepinder, and Edmund S. Sabanegh, Jr. 51 Premature ejaculation, 569Josip Vukina, J. Abram McBride, Culley C. Carson, and R. Matthew Coward Index 579
£151.95
John Wiley and Sons Ltd Decision Making in Dental Implantology
Book SynopsisDecision Making in Dental Implantology: Atlas of Surgical and Restorative Approaches offers an image-based resource to both the surgical and restorative aspects of implant therapy, presenting more than 2,000 color images with an innovative case-by-case approach. Takes a highly pictorial approach to all aspects of implant dentistry Discusses both the surgical and restorative aspects of implant therapy in a single resource Describes a wide range of clinical scenarios likely to be encountered in daily practice Covers anterior, posterior, and full-mouth restorations Presents more than 2,000 color images showing the basic concepts and clinical cases Table of ContentsForeword vii Decision Making in Dental Implantology ix Preface xi About the Authors xiii 1 Current Status of Clinical Practice with Dental Implants: An Evidence-Based Decision Making Overview 1 This chapter presents general aspects to be used in clinical practice with dental implants based on the most relevant up-to-date themes for implantology and other fields of dentistry. Also descriptions on the evidence quality rating/strength of recommendation of procedures proposed by the US Preventive Services Task Force (USPSTF) adapted by the American Dental Association are detailed. 2 Treatment Planning for Bone Defects in the Alveolar Ridge 23 This chapter provides details on the characteristics of the mostfrequent osseous defects the use of bone substitutes/grafting materials for bone filling and the mechanisms/dynamics of osseous repair. 3 Treatment of Esthetic Areas 43This chapter details the rational and clinical use of different treatment modalities in esthetically compromised areas. Cases 1–12. 4 Treatment of Posterior Areas 123 This chapter is exclusively dedicated to the presentation of clinical treatment alternatives for the posterior sites of the mandible and maxilla. Cases 13–27. 5 Implant-Supported Rehabilitation of Completely and Partially Edentulous Patients 205 This chapter is explains the role of certain phases of performing successful implant-supported oral rehabilitation.Cases 28–35. 6 Multidisciplinary Decision Making: The Complexity of Some Potential “Real World” Clinical Scenarios 325This chapter presents offers suggestions for the multidisciplinary construction of treatment approaches for cases presenting high esthetical and functional complexity. These therapies are based on the best evidence available on clinicians’ skills and patients’ desires. Cases 36–41. Index 407
£148.15
John Wiley and Sons Ltd Quick Reference to Dental Implant Surgery
Book SynopsisQuick Reference to Dental Implant Surgery offers busy practitioners quick access to all the essential information needed for successful dental implant surgery from case selection to radiographic examination, scrub-in to post-operative care.Table of ContentsAbout the Author xi Preface and Introduction xiii Case Selection and Diagnosis 1 Part A: Medical Consideration in Implant Dentistry 1 1 Commonly Ordered Blood Tests in Implant Dentistry 1 2 ASA Classifications 3 3 Medical Conditions 4 4 Recommendations for Medical Consideration in Implant Dentistry 6 Part B: Radiographic Examination and Imaging Modalities 8 1 Imaging Strategies 8 2 Radiographic Examination and Imaging Modalities 12 3 Principles of Imaging for Dental Implant Assessment, with Recommendations 15 Part C: Surgical Stents 20 1 SurgicalStentTypes 20 2 Comparison of Surgical Stents 24 3 Recommendations 25 References 25 Surgical Principles and Protocols 27 Part A: Scrubbing and Gowning 27 1 Preparation Prior to Surgical Scrub 27 2 Surgical Scrubbing Methods 27 3 Steps for Surgical Scrubbing 28 4 DryingtheHands 28 5 Gowning 28 6 De-gowning 30 7 Recommendations 30 Part B: Surgical Report 30 1 Principles 30 2 Recommendations 30 Part C: Commonly Used Medications in Implant Dentistry 31 1 Pain Management 31 2 Antibacterial Infection 32 3 Sinus Bacterial Infection 32 4 Xerostomia 33 5 Recommendations 35 References 35 Surgical Treatment 37 Part A: Immediate Implants 37 1 Classification 37 2 Procedure 39 3 General Advantages and Disadvantages 39 4 Complications and Treatment 40 5 Immediate Loading 40 6 Immediate Loading: When To? 40 7 Recommendations 40 Part B: Sinus Augmentation 43 1 MaxillarySinusAnatomy 43 2 Anatomical Considerations 44 3 Procedure Steps 44 4 Recommendations for Complications 47 Part C: Ridge Augmentation 47 1 Soft Tissue Augmentation 47 2 OnlayGrafts 51 3 Titanium Straps, Cores, and Screws 51 4 TitaniumMesh, Distraction Osteogenesis, J Block, and Ridge Expansion 55 5 Membranes 55 6 Recommendations 56 Part D: Extraction Socket Preservation 56 1 Advantages 56 2 Steps for Good Extraction Socket Development 57 3 Complications 57 4 Recommendations 57 Part E: Suture Materials 58 1 Monofilament and Multifilament Sutures 58 2 Absorbable and Non-absorbable Sutures 59 3 Natural and Synthetic Sutures 59 4 Recommendations 60 References 61 Corrective Implant Surgery 63 Part A: Clinical Recommendations for the Prevention and Treatment of Peri-implant Disease 63 Part B: Peri-implantitis Treatment Recommendations 64 References 71 Errors and Complications 73 Part A: Diagnosis of Complications 73 Part B: Surgical Errors 73 1 Early Implant Failure 73 2 Late Implant Failure 74 Part C: Prosthetic Errors 74 Part D: The Checklist 74 1 Basic Implant Placement 74 References 75 Communication 77 Part A: Sample Consents 77 1 Endosseous Implant Consent 77 2 Maxillary Sinus Augmentation Consent 81 3 Conscious Sedation Consent 83 4 Dental Extraction Consent 84 5 Ridge Augmentation Consent 86 6 Bisphosphonates Consent 88 7 BiopsyConsent 89 8 Blank Consent Form 90 9 Gingivectomy Consent 91 10 Gingival Augmentation Consent 92 Part B: Sample Surgical Report 94 Part C: Sample Postoperative Instructions and How to Clean Implants 95 Part D: Sample Patient Letters 98 Part E: Sample Letters to Physicians 99 Part F: Sample Letters to Referring Dentists 99 Index 101
£66.45
