Medical microbiology and virology Books

Book SynopsisThe new edition of this textbook is a complete guide to parasitology for undergraduate and postgraduate medical students. Divided into 29 chapters, each topic has been thoroughly updated and expanded to cover the most recent advances and latest knowledge in the field. The book begins with an overview of parasitology, then discusses numerous different types of parasite, systemic parasitology, and diagnostic methods. Many chapters have been rewritten and the ninth edition of the book features new tables, flow charts and photographs. The content has been arranged in bullet format and each chapter includes key points boxes and case-based MCQs and answers to assist with revision. A useful chart depicting life cycles of various parasites has also been included. Key points Ninth edition providing undergraduates and postgraduates with a complete guide to parasitology Fully revised text with many new topics, tables and photographs Each chapter concludes with ‘key points’ box and MCQs to assist revision Previous edition (9789352701865) published in 2017

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Book SynopsisVirus de ADN es el segundo volumen de la 7.a edición de Fields. Virología, la referencia de mayor autoridad en el tan cambiante mundo contemporáneo de la virología. Esta edición cubre la información más reciente sobre los virus de ADN, la fisiopatología de los padecimientos que causan, cómo persisten en el cuerpo en forma latente, se reactivan y se propagan, y los nuevos enfoques terapéuticos y de vacunas. Además, brinda una cobertura amplia que incluye la biología de los virus, su replicación y los aspectos clínicos de familias específicas de virus.Su contenido abarca todos los virus de ADN de importancia médica, incluidos los que infectan a los seres humanos y a los animales. Además, se plantean varias cuestiones temáticas al examinar los virus de ADN. La organización de los capítulos de esta edición es similar a las anteriores, es decir, la mayoría de los virus se presenta en un único capítulo que combina los aspectos básicos y clínicos de este. Para otros, la virología básica relacionada con la replicación y la patogénesis víricas se divide en dos capítulos.Esta 7.ª edición de Fields. Virología. Virus de ADN presentada a todo color, con múltiples ilustraciones clínicas, figuras y tablas, está dirigida a estudiantes y profesionales de la virología, enfermedades infecciosas, microbiología, medicina interna, familiar, epidemiología, investigadores, inmunólogos y otros profesionales en contacto con pacientes con enfermedades de origen viral.Table of Contents1 Polyomaviridae2 Papillomaviridae: los virus y su replicación3 Papilomavirus4 Adenoviridae: los virus y su replicación5 Adenovirus6 Parvoviridae7 Circoviridae y Anelloviridae8 Familia Herpesviridae: una breve introducción9 Virus del herpes simple: mecanismos de las infecciones líticas y latentes10 Virus del herpes simple: patogénesis y características clínicas11 Virus de Epstein-Barr12 Citomegalovirus13 Virus de la varicela zóster14 Herpesvirus humanos 6A, 6B y 715 Herpesvirus del sarcoma de Kaposi16 Poxviridae: los virus y su replicación17 Poxvirus18 Hepadnaviridae19 Virus de la hepatitis D (delta)20 Mimiviridae

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Book SynopsisFields. Virología: Fundamentos es el cuarto volumen de la emblemática colección Fields. Virología. Esta 7.ª edición, desarrollada por el eminente equipo de autores liderado por los doctores Howley y Knipe, se ha abocado a cubrir los aspectos básicos de la virología, proporcionando, además del contexto histórico, los principios fundamentales, el ingreso y la descapsidación de los virus, la replicación y el ensamblaje víricos y las respuestas inmunitarias del hospedero al virus. Además, se incluyen los capítulos sobre virus de insectos, plantas y bacterias, así como sobre los priones como agentes infecciosos. La serie Fields. Virología es la referencia con mayor autoridad y actualización para virólogos, especialistas en enfermedades infecciosas, microbiólogos y médicos internistas, así como para estudiantes de m

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Book SynopsisThis textbook contains all of the information that is pertinent to medical students studying microbiology. It also provides a solid background of microbiology while describing the organisms in a manner that is clinically relevant.Although, the text was designed to teach undergraduate and postgraduate medical students, it should also serve as a review tool for individuals who are taking medical examinations and persons working in health-related professions, physicians and infectious disease scientists. Key Features: Well balanced coverage of fundamental aspects such as General Bacteriology, Immunology, Systemic Bacteriology, Virology, Medical Mycology, Miscellaneous and Diagnostic Medical Microbiology. Examines etiology, epidemiology, classification, host defences, identification, diagnosis, prevention, and control for each microbe in consistently organized chapters. Each chapter features learning objectives and suggestions for further reading. Correlates basic science with clinical practice through review questions at the end of each chapter to provide an understanding of the clinical relevance of the organisms examined. Illustrated with tables and more than 425 coloured illustrated figures, and photographs.

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Book SynopsisThe book has been written in a simple language and is very student friendly. University question papers, MCQs and a glossary of terms are included to help students in their comprehension. The book has lots of colour illustrations explaining the subject matter.

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Book SynopsisThis new edition has been fully revised to provide the most up to date information in the field of immunology. Beginning with a brief history of the subject, the following chapters cover all aspects of immunology, from basic immunity and antigens, to immunodeficiency disorders including HIV, tumour immunology, and transplantation immunology. This concise second edition is highly illustrated with detailed graphics, colour diagrams, charts and tables, and each chapter features study questions and suggestions for further reading. Key points Fully revised, second edition, providing latest information on complete field of immunology Highly illustrated with graphics, diagrams, charts and tables Study questions and further reading suggestions included in each chapter Previous edition published in 2007 Table of Contents A Short History of Immunology Host-microbe Relationship and Disease Process Immunity Antigen Antigen Recognition Molecules Antigen-antibody Reactions Complement System Cells and Tissues of the Immune System Immune Response Immunological Tolerance Hypersensitivity Autoimmunity Immunodeficiency Disorders Tumor Immunology Transplantation Immunology Immunohematology Immunoprophylaxis Vaccines Immunity in Parasitic, Viral, Bacterial and Fungal Infections

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Book SynopsisThis book correlates basic science with clinical practice through review questions placed at the end of each chapter, which helps students' understanding of the clinical relevance of the organisms examined. Each chapter consists of learning objectives at the beginning. Know more, key points and suggestions for further reading are given at the end for exam preparation and revision. Explains General Bacteriology, Immunology, Systemic Bacteriology, Virology, Medical Mycology, Miscellaneous and Diagnostic Medical Microbiology. Examines etiology, epidemiology, classification, host defences, identification, diagnosis, prevention, and control for each microbe in consistently organized chapters.

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Book SynopsisEssentials of Microbiology is an extensive guide to all aspects of microbiology covering immunology, bacteriology, virology, medical mycology, diagnostic medical microbiology, and many miscellaneous infections. The book is divided into 89 chapters across seven sections. Each chapter begins with an outline and concludes with key points, multiple choice, short and long questions. Two bacteriology sections are included, the first covering the basics of general bacteriology, and the second covering systemic bacteriology, with discussion on the classification, antigen structure, toxins and enzymes, and laboratory diagnosis of various kinds of bacteria. The virology section covers virus structure, classification and evolution, their interaction with host organism physiology and immunity, the diseases they cause, and their use in research and therapy. The mycology section covers fungal infections, and amongst miscellaneous infections covered are microbes of the human body, hospital-acquired infections and hospital waste management. Essentials of Microbiology is enhanced by over 200 images and illustrations and 181 tables. The final chapter on practical microbiology for MBBS students makes this book ideal for medical undergraduates. Key Points Comprehensive guide to microbiology Covers immunology, bacteriology, virology, medical mycology, diagnostic medical microbiology, and many miscellaneous infections 208 images and illustrations, 181 tables Table of ContentsSection 1: General Bacteriology Historical Development of Microbiology Microscopy Morphology of Bacteria Physiology of Bacteria Sterilization and Disinfection Culture Media Culture Methods Identification of Bacteria Bacterial Taxonomy Bacterial Genetics Infection Section 2: Immunology Immunity Antigens Antibodies—Immunoglobulins Complement System Antigen–Antibody Reactions Structures and Functions of the Immune System Immune Response Immunodeficiency Diseases Hypersensitivity Reactions Autoimmunity Immunology of Transplantation and Malignancy Immunohematology Section 3: Systemic Bacteriology Staphylococcus Streptococcus and Entercoccus Pneumococcus (Diplococcus pneumoniae: Streptococcus pneumoniae) Neisseria and Moraxella Corynebacterium Bacillus Clostridium Nonsporing Anaerobes Mycobacterium tuberculosis Mycobacterium leprae Nontuberculous Mycobacteria Actinomycetes Enterobacteriaceae: Escherichia, Klebsiella, Proteus and Other Genera Tribe Proteeae: Proteus, Morganella and Providencia Shigella Enterobacteriaceae III: Salmonella Vibrio, Aeromonas and Plesiomonas Campylobacter and Helicobacter Pseudomonas, Stenotrophomonas, Burkholderia Legionella Yersinia, Pasteurella, Francisella Haemophilus Bordetella Brucella Spirochetes Mycoplasma and Ureaplasma Miscellaneous Bacteria Rickettsiaceae, Bartonellaceae and Coxiella Chlamydia and Chlamydophila Section 4: Virology General Properties of Viruses Virus–Host Interactions: Viral Infections Laboratory Diagnosis, Prophylaxis and Chemotherapy of Viral Diseases Bacteriophages Poxviruses Herpesviruses 4 Adenoviruses Papovaviruses Parvoviruses Picornaviruses Orthomyxovirus Paramyxoviruses Arboviruses Rhabdoviruses Hepatitis Viruses Retroviruses: Human Immunodeficiency Virus (HIV) Slow Virus and Prion Diseases Miscellaneous Viruses Oncogenic Viruses Section 5: Medical Mycology General Properties, Classification and Laboratory Diagnosis of Fungi Superficial, Cutaneous and Subcutaneous Mycoses Systemic Mycoses Opportunistic Mycose Mycotoxicosis Section 6: Miscellaneous Normal Microbial Flora of the Human Body Infective Syndrome Hospital-acquired Infection Laboratory Control of Antimicrobial Therapy Antimicrobial Chemotherapy Immunoprophylaxis Bacteriology of Water, Milk and Air Hospital Waste Management 5 Vehicles and Vectors Emerging and Re-emerging Infectious Diseases Section 7: Diagnostic Medical Microbiology Molecular Detection of Microorganisms Staining Methods Practical Microbiology for MBBS Students Index

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Book SynopsisTable of ContentsPart I: General Microbiology, Immunology and Hospital Infection Control Section 1: General Microbiology Section 2: Immunology Section 3: Hospital Infection Control PART II: Systemic Microbiology (Infectious Diseases) Section 4: Bloodstream and Cardiovascular System Infections Section 5: Gastrointestinal (GI) Infections Section 6: Hepatobiliary System Infections Section 7: Skin, Soft Tissue and Musculoskeletal System Infections Section 8: Respiratory Tract Infections Section 9: Central Nervous System Infections Section 10: Urogenital Tract Infections Section 11: Miscellaneous Infective Syndromes Annexures

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Book SynopsisTable of ContentsSection 1: Core Components of Antimicrobial Stewardship 1. Introduction to Antimicrobial Stewardship 2. Implementation of Antimicrobial Stewardship Program 2.1. Core Elements of AMS Program 2.2. Steps of Implementation of AMS Program in a Hospital 2.3. Role of Information Technology in AMS Program 2.4. AMS Interventions 2.5. Role of Behavioral Change in AMS 3. Monitoring of Antimicrobial Stewardship 4. Current Scenario of Antimicrobial Resistance and Role of AMR Surveillance Section 2: Diagnostic Stewardship 5. Introduction to Diagnostic Stewardship 6. Role of Appropriate Specimen Collection 7. Role of Direct Microscopy 8. Accurate Processing of Clinical Specimens and Reporting of Cultures 9. Role of Accurate Microbial Identification 10. Basics of Antimicrobial Susceptibility Testing 11. Interpretation of Antimicrobial Susceptibility Testing 12. Detection of Specific Antimicrobial Resistance 13. Quality Control in Antimicrobial Susceptibility Testing 14. Direct Susceptibility Testing 15. Selective Reporting and Role of Breakpoint-to-MIC Quotient 16. Comments in Clinical Microbiology Reporting 17. Role of Biomarkers and Point-of-care Tests (POCT) in AMS Section 3: Hospital Antibiogram 18. Introduction to Antibiogram 19. Routine Antibiogram 20. Specialized Antibiograms 21. Use of Antibiogram 22. Analysis of MDR/XDR/PDR Phenotypes Section 4: Antimicrobial Agents 23. Antimicrobial Agents: Classification and PK-PD Considerations 24. Cell Wall Active Agents-I: B-lactams 25. Cell Wall Active Agents-II: Glycopeptides and Fosfomycins 26. Cell Membrane Acting Agents: Polymyxins and Daptomycin 27. Protein Synthesis Inhibitors: Aminoglycosides, Tetracyclines, Glycylcyclines, Macrolides, Lincosamides, Oxazolidinones, Streptogramins, Chloramphenicol and Others 28. Nucleic Acid, Folic Acid Synthesis Inhibitors and Others: Quinolones, Nitroimidazoles, Nitrofurans, Cotrimoxazole and Topical Agents 29. Antitubercular Drugs and Treatment Guidelines 30. Antiviral Drugs 31. Antifungal Drugs 32. Antiparasitic Drugs Section 5: Antimicrobial Therapy (Clinical Stewardship) 33. Empirical Antimicrobial Therapy 33.1. Cardiovascular Infections 33.2. Sepsis and Bloodstream Infections 33.3. Central Nervous System Infections 33.4. Intra-abdominal Infections 33.5. Skin and Soft Tissue Infections 33.6. Respiratory Tract Infections 33.7. Genito-urinary Tract Infections 33.8. Bone and Joint Infections 33.9. Post-cardiovascular Surgery Infections 33.10. Ocular Infections 33.11. Ear Infections 33.12. Burn Wound Infections 33.13. Antimicrobial Policy in Febrile Neutropenia 33.14. Infections in Solid Organ Transplant Recipients (Non-neutropenic Settings) 33.15. Pediatric Infections 33.16. Neonatal Infections 34. Targeted Antimicrobial Therapy for Gram-positive Bacterial Infections 35. Targeted Antimicrobial Therapy for Gram-negative Bacterial Infections 36. Antifungal Stewardship and Treatment of Fungal Infections 37. Antimicrobial Prophylaxis Section 6: Miscellaneous 38. Antimicrobial Stewardship in Special Situations 38.1. AMS in Outpatient Setting 38.2. AMS in Outpatient Parenteral Antimicrobial Therapy (OPAT) Settings 38.3. AMS in Long-term Care Facility Setting 38.4. AMS in Critical Care Units 38.5. AMS in Immunocompromised Patients 38.6. AMS in Pediatric Units 38.7. AMS in Community Hospitals 39. One Health Approach in Antimicrobial Stewardship 40. Hospital Source Control–Unmet Need of an Integrated Antimicrobial Stewardship Practice 41. Puzzles in Rational Use of Antimicrobial Agents

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Book SynopsisTable of ContentsChapter 1. Lactic Acid Bacteria in Reducing Infection Via the Intestinal Immune System Chapter 2. Immunoglobulin A Drug Development as a Gut Microbial Regulator Chapter 3. Altered Humoral Immunity and Antigenic Evolution in Coronavirus Disease 2019 Chapter 4. Dynamics of Probiotic Strains in Human Small Intestinal Tract Chapter 5. Battling Helicobacter pylori with Our Microbial Weapons: The Emerging Era of Novel Microbiome-based Probiotics Chapter 6. Effect of Lacticaseibacillus paracasei Strain Shirota Intake on the Stability of Gut Microbiota in the Elderly Chapter 7. Effects of Probiotics on the Gut-Brain Interaction Chapter 8. Psychobiotics: Workable Approach in Sports? Chapter 9. Synbiotics and Gut Health: Science to Applications

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Book SynopsisThis examinational prep manual for undergraduates covers everything students need to know to pass their microbiology exams. Includes a large number of diagrams and flowcharts. Appendices at the end of book include additional topics. Separate sections for vaccines and staining methods helpful for practical examinations. Table of Contents1. General Microbiology 2. Sterilization and Disinfection 3. Culture Media and Methods 4. Bacterial Genetics 5. Infection 6. Immunology 7. Streptococcus 8. Staphylococcus 9. Neisseria 10. Vibrio Cholera 11. Bacillus 12. Clostridium 13. Tetanus 14. Enterobacteriaceae 15. Non-sporing Anaerobes 16. Bordetella Pertussis 17. Haemophilus Influenzae 18. Corynebacterium Diphtheria 19. Pseudomonas 20. Brucella 21. Mycobacterium Nonmycobacterium 22. Spirochetes 23. Mycoplasma 24. Miscellaneous 25. Rickettsiaceae 26. Chlamydiae 27. General Properties of Viruses 28. Bacteriophage 29. Herpesviruses 30. Orthomyxoviruses 31. Paramyxoviruses 32. Arbovirus 33. Rabies Virus 34. Hepatitis Virus 35. Slow Virus Diseases 36. Miscellaneous Viruses 37. Picornaviruses 38. AIDS 39. Introduction to Parasitology 40. Ameba 41. Intestinal, Oral, and Genital Flagellates 42. Cryptosporidium Parvum 43. Pneumocystis Jirovecii 44. Coccidia 45. Malaria 46. Trematodes 47. Intestinal Flukes 48. Cestodes (Tapeworms) 49. Nematodes 50. Mycology 51. Superficial Mycoses 52. Deep Mycoses 53. Otomycosis 54. Mycotic Poisoning Appendices Index

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Book SynopsisThis revised edition is prepared in such a manner that will help the second year MBBS students to prepare for their MBBS exam as well as for the PG entrances. The chapter review part of each chapter is revised and updated in such a way that by studying this book, the students can easily solve the long essays, short notes of MBBS exams as well as MCQs of various PG entrances.Table of ContentsSection 1: General Microbiology Section 2: Immunology Section 3: Systemic Bacteriology Section 4: Virology Section 5: Mycology Section 6: Parasitology Section 7: Applied Microbiology

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Book SynopsisLeeuwenhoek’s Legatees and Beijerinck’s Beneficiaries: A History of Medical Virology in The Netherlands offers a tour of the history of Dutch medical virology. Beginning with the discovery of the first virus by Martinus Beijerinck in 1898, the authors investigate the reception and redefinition of his concept in medical circles and its implications for medical practice. The relatively slow progress of these areas in the first half of the twentieth century and their explosive growth in the wake of molecular techniques are examined. The surveillance and control of virus diseases in the field of public health is treated in depth, as are tumour virus research and the important Dutch contributions to technical developments instrumental in advancing virology worldwide. Particular attention is paid to oft forgotten virus research in the former Dutch colonies in the East and West Indies and Africa.Trade Review"The use of references from scientists, articles, journals, books, historical records, conference proceedings, seminars, workshops and many resources during the twentieth century made this book an interesting and engaging read. This book will be a valuable addition to any library and to any bioscience student who is interested in the history of microbiology, basic research, infectious diseases, epidemiology, antiviral drugs and vaccination."- Arindam Mitra, Adamas University, India, Microbiology Today (2021) "This unique chronicle of Dutch medical virology is recommended literature for all. It describes scientific highlights of a discipline that allowed a dramatic reduction of morbidity and mortality in the past century."- Ab Osterhaus and Roel Coutinho "The discoveries of the Dutch scientists Van Leeuwenhoek and Beijerinck profoundly influenced the development of microbiology and virology. This book describes the evolution of Dutch medical virology against the context of international developments in the field of virus research."- Harald zur HausenTable of ContentsAcknowledgements Illustrations Abbreviations Preface Chapter 1 Origins in the dark: Virus diseases in the Netherlands before the discovery of viruses Chapter 2 Redefining viruses: the development and reception of the virus concept in the Netherlands Chapter 3 On the fringes: The Dutch work on viruses, 1900-1950 Chapter 4 From cell culture to the molecular revolution: the rise of medical virology and its organization Chapter 5 Medical virology in the Netherlands after 1950. Laboratorries and institutes. Chapter 6 Techniques and instruments: their introduction in The Netherlands and Dutch main contributions Chapter 7 Dutch virology in the tropics: From colonial to international virology Chapter 8 From cancer mice in the roaring twenties to oncogenes and signalling molecules in the booming nineties Chapter 9 Virus vaccines and immunisation programmes Chapter 10 Conclusions List of institutes and laboratories References Index of Names Index of subjects

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Book SynopsisWhy does the World Health Organization (WHO) put emphasis on neglected tropical diseases (NTDs)? What are the NTDs? Are NTDs found in the United States? Is there any relationship between coronavirus disease 2019 (COVID-19) and NTDs? These are some of the questions being addressed in the book.The aim of this textbook is to introduce a modern synthesis on human parasites of medical importance. Species of parasitic protozoa and helminths are presented in detail, from history and discovery to aspects of genomes and molecular biology, together with life cycle, therapy, drug resistance, and case studies of parasitic diseases useful to the clinicians.

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Book SynopsisThis book will guide readers through the history of the flu. In ten chapters, it explains Influenza in a simple way. Influenza always seems to have endless topics. The flu virus, seemingly tiny, has brought on one disaster after another to human beings. 2018 is the 100th anniversary of the outbreak of the '1918 Flu' that swept the world. The flu, a century ago, claimed nearly one-twentieth of human life on the planet. It became the most deadly flu in human history.This book introduces the past and present life of the influenza virus in a light-hearted way, leading the reader to review the past from the history of the flu, the development of the flu, human immunity and health, impacts on society and the country. Through touching stories, illustrations and diagrams, it tells the great discoveries and related advances in science and technology, introduces medical knowledge related to influenza, and reviews the medical effectiveness in preventing influenza, thus displaying the ongoing battle between humans and the flu virus.Looking back at the development of science and technology, humans have relentlessly sought the prevention and control of this infectious disease, constantly guarding the path of life and health, which gradually becomes a quiet past, but only to awaken again and again.

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Book SynopsisThis curated collection of scientific papers on the origin and global spread of COVID-19 is a unique project that offers explanations at odds with mainstream views as the theme mainly focuses on Panspermia (viruses, microorganisms and their spores, and cometary arrival of even more complex cellular organisms).No other scientific group has paid attention to the temporal unfolding scientific order at the many required levels of understanding — astrobiological and astrophysical, geographical and the temporal order of global proportions, yet regional epidemics, the immunologic dimensions to the infection and epidemic data, the genetics of the SARS-CoV-2 virus as it adapted, varied and appeared in different human populations in the crucial first few months of the pandemic. This in-depth analysis, over a two-year period, allows a better understanding of what engulfed the world during the COVID-19 pandemic, how it happened and the most plausible way.There are many lessons for future generations that can be distilled from the contributions found in this book.

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Book SynopsisCOVID Chaos is a book about the 2019 SARS-CoV-2 Pandemic that was written real time, spanning the time from March 31, 2020 through December 31, 2021, by two Emeritus Professors of Infectious Diseases (Adult - RJS, Pediatrics - JSA). RJS's and JSA's careers began with the HIV pandemic, involved collaboration with the 2009 Influenza pandemic, and now are finishing up with the Coronavirus pandemic. The authors have broad experience with outbreaks, from the local level (RJS had career long responsibilities for controlling outbreaks at medical school hospitals and worked taking care of COVID-19 patients during the pandemic), all the way up to the pandemic level (JSA wrote a book about the 2009 Influenza pandemic and has worked with the WHO for the past 10 years.The aim of the book is to give the reader some insight into the global impact of the SARS-CoV-2 outbreak during the first two years, from multiple perspectives (patient, healthcare provider, global citizen, public health, economic, geopolitical). An attempt was also made to understand how SARS-CoV-2 caused disease, both its pathogenesis at the individual patient level, and globally, as to how it was so successful at causing a pandemic and how it compares with other organisms capable of causing outbreaks, epidemics and pandemics. It is written to be of interest to anyone who likes to read and wants to know more about what happened during the COVID-19 pandemic and why.COVID Chaos was written by two infectious disease physicians, who each have over 35 years of experience caring for patients with a large variety of infectious diseases. Additionally, both did research in understanding the pathogenesis of infectious diseases, and collectively have many years of experience handling outbreaks at the local level, have been involved with guideline documents making recommendations for reducing infections at the national level, and have global experience managing international infectious diseases.The book begins with three first person accounts from physicians involved in COVID-19 care during the early pandemic, when it was overwhelming hospitals.It then tracks its course from Wuhan, China, to other parts of the world, while comparing and contrasting public health interventions, both at the hospital and local community level, all the way up to country level.The book attempts to understand the broad spectrum of COVID-19 disease, both clinically and pathophysiologically, as well as its global collateral damage. It explores in depth SARS-CoV-2 vaccine development, testing and the geopolitical problems with vaccine deployment, and attempts to understand the origin of SARS-CoV-2 and its place in the pantheon of other organisms causing pandemics.The book concludes with some late breaking pandemic events at the end of 2021 (Omicron variant, etc.) and a global photo essay about the pandemic.

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Book SynopsisCOVID Chaos is a book about the 2019 SARS-CoV-2 Pandemic that was written real time, spanning the time from March 31, 2020 through December 31, 2021, by two Emeritus Professors of Infectious Diseases (Adult - RJS, Pediatrics - JSA). RJS's and JSA's careers began with the HIV pandemic, involved collaboration with the 2009 Influenza pandemic, and now are finishing up with the Coronavirus pandemic. The authors have broad experience with outbreaks, from the local level (RJS had career long responsibilities for controlling outbreaks at medical school hospitals and worked taking care of COVID-19 patients during the pandemic), all the way up to the pandemic level (JSA wrote a book about the 2009 Influenza pandemic and has worked with the WHO for the past 10 years.The aim of the book is to give the reader some insight into the global impact of the SARS-CoV-2 outbreak during the first two years, from multiple perspectives (patient, healthcare provider, global citizen, public health, economic, geopolitical). An attempt was also made to understand how SARS-CoV-2 caused disease, both its pathogenesis at the individual patient level, and globally, as to how it was so successful at causing a pandemic and how it compares with other organisms capable of causing outbreaks, epidemics and pandemics. It is written to be of interest to anyone who likes to read and wants to know more about what happened during the COVID-19 pandemic and why.COVID Chaos was written by two infectious disease physicians, who each have over 35 years of experience caring for patients with a large variety of infectious diseases. Additionally, both did research in understanding the pathogenesis of infectious diseases, and collectively have many years of experience handling outbreaks at the local level, have been involved with guideline documents making recommendations for reducing infections at the national level, and have global experience managing international infectious diseases.The book begins with three first person accounts from physicians involved in COVID-19 care during the early pandemic, when it was overwhelming hospitals.It then tracks its course from Wuhan, China, to other parts of the world, while comparing and contrasting public health interventions, both at the hospital and local community level, all the way up to country level.The book attempts to understand the broad spectrum of COVID-19 disease, both clinically and pathophysiologically, as well as its global collateral damage. It explores in depth SARS-CoV-2 vaccine development, testing and the geopolitical problems with vaccine deployment, and attempts to understand the origin of SARS-CoV-2 and its place in the pantheon of other organisms causing pandemics.The book concludes with some late breaking pandemic events at the end of 2021 (Omicron variant, etc.) and a global photo essay about the pandemic.

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Book SynopsisThis book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.Table of ContentsChapter 1. Emergence of antibiotic resistant bacteria.- Chapter 1.1. Era of antibiotic discovery.- Chapter 1.2. Emergence of antibiotic resistant microbes immediate after the discovery of antibiotics.- Chapter 1.3. Newly discovered antibiotics of 21st century.- Chapter 2. Impact of antibiotic resistant bacteria on different field.- Chapter 2.1. Antibiotic resistance: Role and pattern in different class of bacteria.- Chapter 2.2. Effect of drug resistant bacteria on agriculture, medical society, livestock and environment.- Chapter 3. Antibiotic resistance: Pattern and Mechanisms.- Chapter 3.1. Intrinsic antibiotic resistant mechanism in bacteria.- Chapter 3.2. Extrinsic antibiotic resistant mechanism in bacteria .- Chapter 3.3. Chemical mediated alteration of antibiotics.- Chapter 4.1. Novel strategies for overcoming of antibiotic resistant mechanisms.- Chapter 4.2. Collapsing of antibiotic resistance with the help of genetic approaches.- Chapter 4.3. Bacteriophage: A new hope for the control of antibiotic resistant bacteria.- Chapter 4.4. Nanotechnology: A 21st Century approach towards the control of antibiotic resistant bacteria.- Chapter 5. Future Prospects.

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Book SynopsisThis book covers state-of-the-art topics covering evidences indicate that the gut microbiota can be harnessed for cancer prevention as well as to modulate the efficacy of chemotherapy and immunotherapy. This book includes: 1) characterization of the dysregulated microbiome in gastrointestinal cancers (Chapters 1-6); 2) the molecular mechanism of action of gut microbiota via microbial metabolites and direct interaction with host cancer or immune cells (Chapters 7-11); 3) key methodologies for studying the role of gut microbiota in cancers (Chapters 12-13); and 4) the potential application of gut microbes for the prevention and treatment of gastrointestinal cancers (Chapters 14-17). The contributors are international experts in molecular and cellular biology, microbiology, metabolomics, bioinformatics and physician scientists to provide in-depth reviews of this subject. This book provides a rich resource of information on this important topic for graduate students, basic researchers and physicians.Table of ContentsIntroduction.- Gut microbiome in health and diseases.- Microbiome in colorectal cancer.- Microbiome in gastric cancer.- Microbiome in liver cancer.- Virus, fungi and archaea in gastrointestinal cancer.- Microbial metabolomics in gastrointestinal cancer.- Diet and gut microbiome in gastrointestinal cancer.- Diet and gut microbiome in fatty liver and its associated liver cancer.- Host-microbiome interaction in gastrointestinal cancer.- Gut microbiome and immune responses in gastrointestinal cancer.- Animal models in the study of microbiome in gastrointestinal cancer.- High-throughput sequencing data analyses for microbiome profiling.- Gut microbiota modulation: probiotics and prebiotics in gastrointestinal cancer.- Roles of gut microbiota in efficacy of anticancer treatment of gastrointestinal cancer.- Targeting gut microbiota to treat gastrointestinal cancer.

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Book SynopsisViruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epstein-Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1.This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.Table of ContentsViruses and Cellular Transformation; Hepatitis B Virus; Hepatitis C Virus; Human Papilloma Viruses; Epstein-Barr Virus; Kaposi's Sarcoma Virus; Human T-Cell Leukemia Virus Type I.

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Book SynopsisThis is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.Organized into 27 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host-virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.Table of ContentsRetrovirus: Efforts to Characterize Host Response to HIV-1 Infection (M Montano & P Sebastiani); Host Immune Responses in HIV Infection (R D Allison & S Kottilil); Negative Single-Stranded RNA Virus: Host Immune Response to Influenza Virus (T M Moran & C B Lopez); Innate Recognition of Viral Infection and the Involvement of Autophagy (B Ramanathan & A Iwasaki); Hantavirus Infection and Innate Immunity (N Sen et al.); Positive Single-Stranded RNA Virus: Impact of Filovirus Infection upon Cellular Signaling Pathways (C F Basler); Host Signaling Responses to Coxsackievirus Infection (G Gao et al.); Double-Stranded RNA Virus: Host Signaling Responses to Reovirus Infection (D Pan et al.); Rotavirus Antagonism of the Host Innate Immune Response (J T Patton & M Barro); and other papers.

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Book SynopsisMicrobial infections have been and continue to be a major threat to public health. China has a huge population, among which, microbial infections are of great concern. The Journal of Microbes and Infection, a nationwide journal in China with over 4000 subscriptions, publishes original research articles on microbes and infections in the Chinese language. This book contains selected research articles published in this journal from 2006 to 2007 that have been translated into English, and offers a glimpse of a broad range of microbial infections including the clinical and epidemiological aspects of various viral infections, current status of bacterial infections in hospitals, and severe cases of fungal infections. This book provides a rare opportunity for scientists and physicians abroad to see the completely original research data, rather than just the abstract, based on studies conducted in modern China. Articles on molecular biological and bioinformatic studies are also included. An overview of the recent research trend in medical microbiology and infectious diseases in China will be presented as well. Scientists and physicians working in the fields of virology, microbiology, immunology, epidemiology, vaccinology, and infectious diseases will find the articles in this book fascinating and relevant to their own research and practice.Table of ContentsViruses and Viral Infections: Influenza; Measles; Viral Hepatitis; HIV; Coxsackie Virus Infections; Avian Flu; HCMV; Mumps; Bacteria and Bacterial Infections: TB; Other Mycobacteria; Streptococcus suis; Brucellosis; Mycoplasma Urea; Leptospira; Fungi and Fungal Infections: Cryptococcus; Aspergillus.

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Book SynopsisHuman adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.Table of ContentsA Short History; Structure of Virus Particles; Cell Attachment and Entry; ntracellular Trafficking; Organization and Expression of the Genome; Genome Replication; Assembly and Maturation of Progeny Virus Particles; Pathogenesis; Anti-Viral Defenses; Antivirals; Therapeutic Applications;

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Book SynopsisThere are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable book that integrates the findings from the three known classes of human retroviruses. Other books have focused on one of the three classes of human retroviruses individually.An accomplished international team of contributing authors have combined their expertise to provide cutting-edge findings in this important field. The book will be a valuable reference for students, researchers and medical professionals.Table of ContentsThe Role of Hematopoietic Progenitor Cells in Retroviral Pathogenesis (P Banerjee et al.); Human T Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T Cell Leukemia (J Yasunaga & K-T Jeang); Application of Proteomics to HTLV-1: Understanding Pathogenesis and Enhancing Diagnostics (O J Semmes et al.); Antisense Transcription in Human T-Cell Leukemia Virus Type 1: Discovery of a New Viral Gene (B Barbeau et al.); Regulation of HTLV-1 Transcription by Viral and Cellular Proteins (N Polakowski & I Lemasson); Cellular Factors Involved in HIV-1 RNA Transport (C Williams et al.); Integration Site Selection by Retroviruses and Retroviral Vectors (C Cattoglio & F Mavilio); Syncytins in Normal and Pathological Placentas (A Malassine et al.); Vpu, Tetherin and Innate Immunity: Antiviral Restriction of Retroviral Particle Release (S J D Neil); Retrovirus Replication: New Perspectives on Enzyme and Substrate Dynamics (J W Rausch et al.); Non-Human Primates in HIV-1 Research (W M J M Bogers); Lentiviral Integration and the Role of the Cellular Cofactors LEDGF/P75 and Transportin-SR2 (B Van Heertum et al.); Retrovirus Restriction Factors (R S Harris et al.); Rev Revisited: Additional Functions of the HIV-1 Rev Protein (B Grewe & K A berla); HIV-1 Interactions with Small RNA Induced Silencing Mechanisms (J Haasnoot & B Berkhout);

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Book SynopsisThis book contains a series of review chapters from the world's leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.Table of ContentsThe HSV-2 Gene ICP10PK: A Future in the Therapy of Neurodegeneration (Laure Aurelian); What Doesn't Belong and Why: A Saga of Latency Associated Proteins Elaborated by Varicella Zoster Virus (Matthew S Walters, Christos A Kyratsous, Christina L Stallings, Octavian Lungu and Saul J Silverstein); Selected Aspects of Herpesvirus DNA Replication, Cleavage/Packaging and the Development and Use of Viral Amplicon Vectors (Niza Frenkel, Ronen Borenstein and Haim Zeigerman); Chromatin Structure of the Herpes Simplex Virus 1 Genome During Lytic and Latent Infection (Anna R Cliffe and David M Knipe); The Proboscivirus Genus: Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesviruses (Jian-Chao Zong, Erin Latimer, Sarah Y Heaggans, Laura K Richman and Gary S Hayward); A Molecular Mass Gradient is the Key Parameter of the Genetic Code Organization (Felix Filatov); From Latent Herpes Viruses to Persistent Bornavirus Dedicated to Bernard Roizman (Hanns Ludwig and Liv Bode); Virus Infections and Development of Cervical Cancer (Bodil Norrild); Cytomegalovirus Control of Cell Death Pathways (A Louise McCormick and Edward S Mocarski); Herpesviruses as Oncolytic Agents (Gabriella Campadelli-Fiume, Laura Menotti, Grace Zhou, Carla De Giovanni, Patrizia Nanni and Pier Luigi Lollini; Role of Cellular MicroRNAs During Human Cytomegalovirus Infection (Kavitha Dhuruvasan, Geetha Sivasubramanian and Philip E Pellett); Burkitt's Lymphoma and EBV - The Role of LMP2A (Kathryn T Bieging and Richard Longnecker); Replicative Herpes Simplex Virus Vectors for Therapy of Autoimmune Central Nervous System Disease (Veijo Hukkanen, Michaela Nygardas and Eeva Broberg); The Herpes Simplex Virus DNA Packaging Machine (Joel D Baines); Post-Transcriptional Gene Regulation: Role of the Polypyrimidine Tract-Binding Protein (PTB) and Associated Factors (Maria Grazia Romanelli and Erica Diani); Nucleotidylation to Oncoapoptosis (John A Blaho, Martine Aubert, Kathy Bae, Brooke Baker, Jenny Balderama, Renee Baranin, Monica Bhanot, Amanda Blouin, Robert N Bowles, Isabella Chi, F Natalie W Chirimuuta, Christopher R Cotter, Elisabeth Gennis, Laura Gillim, Margot L Goodkin, Kristin Ingvarsdottir, Andrea E Ireland, Leah Kang, Surinder Kaul, Anna Kotsakis, Rachel M Kraft, Renzo C Lambardozzi, Maria R Lopez, Fatima Manzoor, Kerryn A Mortimer, Elise R Morton, Marie L Nguyen, Jennifer M O'Toole, Jason Paragas, Kristen C Pena, Lisa E Pomeranz, Deleen Sabbah, Christine M Sanfilippo, Louis R Serico, Elisabeth F M Schlegel, Chintal Shah, Cecylia Stabrawa, Dennis Vega, Sandra Winstersteller, Jamie C Yedowitz and C Susan Zong); Geographic Distribution and High Frequency of Herpes Simplex Virus Type 1 BgKL Variant in Orolabial/Cutaneous Infections: The HSV-1 Variant Dispersion-Replacement Model (Kazuo Yanagi); Virucidal Ability of Arginine and Its Possible Application as an Antiherpetic Agent (Keiko Ikeda, Hisashi Yamasaki, Sawako Minami, Takeshi Naito, Hiroshi Irie, Tsutomu Arakawa and A Hajime Koyama); Genetic Analyses of Human Cytomegalovirus Towne Strain by Deletion Mutagenesis (Edward Yang, Paul J Rider and Fenyong Liu); Angiogenic and Oncogenic Alterations of Endothelial Cells by KSHV (Valerie A Morris, Terri Dimaio, Almira S Punjabi and Michael Lagunoff); Decoding Neural Circuitry with Optogenetics: Applications for Epilepsy (Philip Barish, Svetlana Kantorovich, Paul Carney and William Ogle); From Psychosocial Stress to Herpes Simplex Infection: A Sequence of Coordinated Events Regulated in a Cascade Fashion (Rosario Leopardi and Alessandro Bartolomucci); Herpes Simplex Viruses and Interferon Responses (Yijie Ma and Bin He); Herpes Virus Genes and Gene Regulation: Insights from Systems Biology (Joanne Trgovcich); Viral Manipulation of Cellular Metabolic Signal Transduction Pathways (Joshua Munger); How Herpesviruses and Cells Tussle to Control Autophagy (Audrey Esclatine); Epilogue - Kovler Poems (Susanna Rudofsky).

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Book SynopsisEmerging diseases are a major threat to modern societies, impacting individual welfare as well as economic development. The trend of newly emerging diseases has accelerated in the last two decades to such an extent that a new emerging infection is described at least once a year.The majority of such threats to modern society have been due to emergent viruses. This series of lecture notes provides grounding in understanding the drivers of disease emergence, the molecular processes which allow for virus diversity, the response of the host and environmental factors responsible for changing the balance between host and pathogen. Groups of viruses are described, each selected to illustrate certain features of disease emergence. These examples best illustrate how from past experience we may best be able to predict future outbreaks of novel diseases.Expecting the unexpected is a major challenge for health care personnel and public health officials alike, and the stakes have never been higher. As such, this book provides a timely overview of how best to prepare for disease emergence as it intends to increase awareness of how vulnerable modern society is in preparedness for such events.Table of ContentsOverview; Drivers of Virus Emergence; Molecular Basis of Virus Emergence; Influenza Viruses; SARS and Other Coronaviruses; Henipaviruses; Rabies and Other Lyssaviruses; Filoviruses; Arenaviruses; Bunyaviruses; Chikungunya Virus; Flaviviruses; Hepatitis E Virus; Future Challenges.

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Book SynopsisRhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents.Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included.This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis.Table of ContentsOverview of Rhabdo- and Filoviruses (Asit K Pattnaik & Michael A.Whitt); Rhabdovirus Structure (Ming Luo); The Pathway of VSV Entry into Cells (Shem Johnson & Jean Gruenberg); Rhabdovirus Glycoproteins (Yves Gaudin & Michael A Whitt); VSV RNA Transcription and Replication (Jacques Perrault); Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, & Asit K.Pattnaik); Cytopathogenesis of Rhabdoviruses (Douglas S Lyles); Assembly and Budding of Rhabdo- and Filoviruses (Ziying Han & Ronald N Harty); Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose & David K Clarke); Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell); Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl & Andreas Frick); Evolution of Rhabdo- and Filoviruses (Isabel S Novella, John B Presloid & R Travis Taylor); Emerging Rhabdoviruses (Imke Steffen & Graham Simmons); Rabies Virus Replication and Pathogenesis (Andrew W Hudacek & Matthias J Schnell); Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann); Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai & Zhen F Fu); Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel Beniac, Melissa Rabb, & Lindsey Lamboo); Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga & Hideki Ebihara); Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler & Kartik Chandran); Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflube & Elke Muhlberger); Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe & Daisy W Leung); Vaccines and Antivirals for Filoviruses (Chad E Mire & Thomas W Geisbe);

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Book SynopsisSelected as CHOICE magazine's Outstanding Academic Title, January 2017.The book is a narrative of the unfolding of the Ebola virus disease outbreak from a scientific view point. The author provides an analysis of the scientific basis of public health policies that have influenced the public's, and the medical community's, abilities to understand the virus and the disease. This is done in the context of providing insights into the biology of the virus, and exploring open questions, including its likely modes of transmission. The author has included citations from the scientific literature and the press, as well as quotes from expert interviews. The book will help sort out the fact from fiction, given the confusion that arose after the virus arrived in the US. The author used his objective research skills and knowledge of evolutionary genetics and molecular biology to find out what was known, and what questions remained unanswered, and even what questions remained unasked.Written in an accessible style, it is intended for the educated general public, scientists, policy makers, health care workers, and politicians. It delves into the problems of trying to derive a logic-based understanding of a highly lethal emerging disease in 2014, when research funding cuts have gutted research institutions, and when public health institutions really were woefully unprepared. It is a highly distinct narrative analysis that is sure to stimulate new research and thinking in public policy. It will inform thousands of people of the nature of the virus, how it works, in terms they are likely to be able to understand. It will allow others to rapidly catch up with the story of Ebola.Table of ContentsOrigins of the Epidemic; How Well Do We Understand the 2014 Ebolavirus?; Ways in Which Ebola 2014 May Differ from Past Outbreaks: Evolution of Viral Phenotypes; Biological Knowledge and Ebola Policy; "How Cruel is That?"; With Blinded Eyes; Are We Asking the Right Questions and Solving All the Right Problem(s)?; Evolution is Real, or, Deadly Consequences of Dogma; Promising Treatments; Policy Analysis; A Rational Analysis of Irrational Decisions, or Don't Fear the Reaper;

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Book SynopsisSelected as CHOICE magazine's Outstanding Academic Title, January 2017.The book is a narrative of the unfolding of the Ebola virus disease outbreak from a scientific view point. The author provides an analysis of the scientific basis of public health policies that have influenced the public's, and the medical community's, abilities to understand the virus and the disease. This is done in the context of providing insights into the biology of the virus, and exploring open questions, including its likely modes of transmission. The author has included citations from the scientific literature and the press, as well as quotes from expert interviews. The book will help sort out the fact from fiction, given the confusion that arose after the virus arrived in the US. The author used his objective research skills and knowledge of evolutionary genetics and molecular biology to find out what was known, and what questions remained unanswered, and even what questions remained unasked.Written in an accessible style, it is intended for the educated general public, scientists, policy makers, health care workers, and politicians. It delves into the problems of trying to derive a logic-based understanding of a highly lethal emerging disease in 2014, when research funding cuts have gutted research institutions, and when public health institutions really were woefully unprepared. It is a highly distinct narrative analysis that is sure to stimulate new research and thinking in public policy. It will inform thousands of people of the nature of the virus, how it works, in terms they are likely to be able to understand. It will allow others to rapidly catch up with the story of Ebola.Table of ContentsOrigins of the Epidemic; How Well Do We Understand the 2014 Ebolavirus?; Ways in Which Ebola 2014 May Differ from Past Outbreaks: Evolution of Viral Phenotypes; Biological Knowledge and Ebola Policy; "How Cruel is That?"; With Blinded Eyes; Are We Asking the Right Questions and Solving All the Right Problem(s)?; Evolution is Real, or, Deadly Consequences of Dogma; Promising Treatments; Policy Analysis; A Rational Analysis of Irrational Decisions, or Don't Fear the Reaper;

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