Medical microbiology and virology Books

Book SynopsisDrug-resistant bacteria — known as superbugs — are one of the biggest medical threats of our time. Here, a doctor, researcher, and ethics professor tells the exhilarating story of his race to beat them and save countless lives. When doctor Matt McCarthy first meets Jackson, a mechanic from Queens, it is in the ER, where he has come for treatment for an infected gunshot wound. Usually, antibiotics would be prescribed, but Jackson’s infection is one of a growing number of superbugs, bacteria that have built up resistance to known drugs. He only has one option, and if that doesn’t work he may lose his leg or even his life. On the same day, McCarthy and his mentor Tom Walsh begin work on a groundbreaking clinical trial for a new antibiotic they believe will eradicate certain kinds of superbugs and demonstrate to Big Pharma that investment in these drugs can save millions of lives and prove financially viable. But there are seemingly endless hoops to jump through before they can begin administering the drug to patients, and for people like Jackson time is in short supply. Superbugs is a compelling tale of medical ingenuity. From the muddy trenches of the First World War, where Alexander Fleming searched for a cure for soldiers with infected wounds, to breakthroughs in antibiotics and antifungals today that could revolutionise how infections are treated, McCarthy takes the reader on a roller-coaster ride through the history — and future — of medicine. Along the way, we meet patients like Remy, a teenage girl with a dangerous and rare infection; Donny, a retired firefighter with a compromised immune system; and Bill, the author’s own father-in-law, who contracts a deadly staph infection. And we learn about the ethics of medical research: why potentially life-saving treatments are often delayed for years to protect patients from exploitation. Can McCarthy get his trial approved and underway in time to save the lives of his countless patients infected with deadly bacteria, who have otherwise lost all hope?Trade Review‘There might not be another author who so fluidly combines a world-class doctor and researcher's knowledge and experience with a memoirist's sensibility. Matt McCarthy is Siddhartha Mukherjee and David Sedaris rolled into one. Who else but McCarthy could write a dispatch from the front lines of the secret fight for the future of the human race that is not just gripping and illuminating, but also poignant and funny?’ -- Ben Reiter, New York Times bestselling author of Astroball‘Written from the front lines in the battle against resistant microbes, Superbugs will educate and inspire all those concerned about the growing threat to individuals and society. McCarthy offers a fast paced, vivid narrative that grips the reader from the opening pages and never lets go.’ -- Dr. Jerome Groopman, Recanati Professor at Harvard Medical School, and co-author of New York Times bestseller Your Medical Mind‘Superbugs is a riveting look into the world of bacteria and antibiotics. Dr. Matt McCarthy offers a compulsively readable tour through infectious disease. With his characteristic humour and warmth, Dr. McCarthy humanises a fascinating and timely topic that has resonance for us all. In a voice that is thoughtful and honest, punctuated by sharp wit, he reveals the drugs and dilemmas that will impact humanity for years to come. This is a rare and important book.’ -- Daniela Lamas, author of You Can Stop Humming Now‘An amazing informative book that changes our perspective on medicine, microbes and our future’ -- Dr. Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies‘A perfect work of popular science. Like Atul Gawande, Matt McCarthy has the magical ability to transmit deeply technical knowledge in a way that makes the reader feel like part of a high-level professional conversation; like Michael Lewis, a gift for the place where big ideas overlap; like Elizabeth Kolbert, a sense of narrative urgency about the state of the present world that makes anything outside its pages seem trivial. Magnificent.’ -- Charles Finch, winner of National Book Critics Circle Award‘Dr. Matt McCarthy … writes about the ‘microscopic miracles’ that lie beneath the soil.’ -- Sarah Berry * Sydney Morning Herald *‘The rise of the superbug has transformed each working hour into a battle to outwit the treatment-resistant bacteria that threaten patients’ lives … In McCarthy’s new book, he explains through the stories of his patients what antibiotic resistance means to every one of us.’ -- Simon Crompton * The Times *‘Intriguing ... This book discusses many big things, along with microscopic ones, and the two combine to provide a valuable insight to a challenge facing us all, whether doctor or patient.’ -- Robin Osborne * GPSpeak *‘It is a fascinating read, enhanced by his detours into medical history ... McCarthy can wring suspense from fungal infection and faculty meetings.’ -- Jenny Nicholls * North and South *‘Mostly heart-breaking, but at times laugh-out-loud funny … Superbugs is an immersive and educational read that combines feelings of futility with a sense of hope at just the right moments.’ -- Anna Kosmynina * COSMOS *‘A riveting insider’s look at the race to find a cure for antibiotic-resistant infections, one of the most pressing challenges in modern medicine … The author’s storytelling is at once urgent and empathetic, a compelling combination that leaves readers feeling informed and optimistic. Insightful and honest, McCarthy effectively combines useful information about the latest advances in microbial research with accounts of the best aspects of humanity.’ * Kirkus Reviews *‘McCarthy gives an insider’s look at the history of antibiotics and the urgent fight against deadly, drug-resistant bacteria.’ * People *‘Dr. McCarthy offers a glimmer of hope: a new way to both cure and prevent future superbug infections with a single treatment.’ * Christian Broadcasting Network *‘McCarthy weaves the history of the life-saving drugs into a suspenseful account of his own role in a groundbreaking clinical trial.’ * The Boston Globe Magazine *‘It may sound like another sci-fi superhero movie, but physician and author Matt McCarthy warns that the topic of lethal bacteria is not to be taken lightly … McCarthy explains how these pathogens have built up a resistance to our current arsenal of antibiotics.’ * NPR’s All Things Considered *‘Cutting-edge science.’ * Twin Cities Pioneer Press *‘Sheds a lot of light on an issue that should be in the public consciousness.’ * SF Gate *‘Incredibly interesting with a good mix of the scientific and human aspects … McCarthy also goes into the history of antibiotic development and the economics of today’s drug development that limit the research for new antimicrobials … The book is easy to read, and never dull due to the patient interactions. McCarthy explains novel concepts in a simple, easy to understand way.’ * Sam Still Reading *

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Book SynopsisThis textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.Table of Contents1. A Short History of Microbiology 2. The Form and Function of a Bacterial Cell 3. The Practice of the Microbe Hunter 4. Innate Immunological Defenses against Bacterial Attack 5. Adaptive Immunological Defenses against Bacterial Attack 6. The Mutagenic Tetrasect7. Bacterial Bindance: Adhesins and their Engagement to Host 8. Bacterial Invasion of the Host Cell 9. Bacterial Secretion Systems 10. Bacterial Protein Toxins and Effectors 11. The Acquisition and Consumption of Host Nutrients12. Biofilms13. The Human Microbiome14. Sepsis15. Bacterial Vaccines and the Challenges Ahead16. Antibiotics … and their destruction

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Book SynopsisThis textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.Table of ContentsSection I. Introduction​Chapter 1. Introduction to Immunology, Epidemiology, and ImmunoepidemiologyLinda Niccolai, Nancy H. Ruddle, and Peter J. KrauseChapter 2. Organization and Cells of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 3. Innate Immunity: Recognition and Effector FunctionsPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 4. Adaptive Immunity: Antigen Recognition by T and B LymphocytesPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 5 Adaptive Immunity: Effector Functions, Regulation, and VaccinationPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 6. Disorders of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 7. Polymorphisms of Selected Components of the Innate and Adaptive Immune SystemsNancy H. Ruddle and Paula B. KavathasChapter 8. Immunoepidemiology of Immune DysfunctionEric Meffre, Peter J. Krause and Nancy H. RuddleChapter 9. Immunoepidemiology of Mycobacterium tuberculosisCamila D. Odio, Richard J. BucalaChapter 10. Host Immunity to Human immunodeficiency Virus InfectionElijah PaintsilChapter 11. Fungal ImmunoepidemiologyMarwan M. AzarChapter 12. Immunoepidemiology of Plasmodium falciparum MalariaAmy K. Bei, Sunil ParikhChapter 13. Immunoepidemiology of CancerXiaomei Ma, Rong WangChapter 14. Modeling Approaches Toward Understanding Infectious Disease TransmissionLaura A. Skrip, Jeffrey P. TownsendChapter 15. VaccinesDiane McMahon-PrattChapter 16. Immunotherapy for Infectious Diseases, Cancer, and AutoimmunityPeter J. Krause, Paula B. Kavathas, Nancy H. RuddleAppendixJane O'Bryan, Kara Fikrig, Peter J. Krause, Kate Nyhan

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