Immunology Books

Book SynopsisThis textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.Table of Contents1. A Short History of Microbiology 2. The Form and Function of a Bacterial Cell 3. The Practice of the Microbe Hunter 4. Innate Immunological Defenses against Bacterial Attack 5. Adaptive Immunological Defenses against Bacterial Attack 6. The Mutagenic Tetrasect7. Bacterial Bindance: Adhesins and their Engagement to Host 8. Bacterial Invasion of the Host Cell 9. Bacterial Secretion Systems 10. Bacterial Protein Toxins and Effectors 11. The Acquisition and Consumption of Host Nutrients12. Biofilms13. The Human Microbiome14. Sepsis15. Bacterial Vaccines and the Challenges Ahead16. Antibiotics … and their destruction

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Book SynopsisThis textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.Table of ContentsSection I. Introduction​Chapter 1. Introduction to Immunology, Epidemiology, and ImmunoepidemiologyLinda Niccolai, Nancy H. Ruddle, and Peter J. KrauseChapter 2. Organization and Cells of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 3. Innate Immunity: Recognition and Effector FunctionsPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 4. Adaptive Immunity: Antigen Recognition by T and B LymphocytesPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 5 Adaptive Immunity: Effector Functions, Regulation, and VaccinationPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 6. Disorders of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 7. Polymorphisms of Selected Components of the Innate and Adaptive Immune SystemsNancy H. Ruddle and Paula B. KavathasChapter 8. Immunoepidemiology of Immune DysfunctionEric Meffre, Peter J. Krause and Nancy H. RuddleChapter 9. Immunoepidemiology of Mycobacterium tuberculosisCamila D. Odio, Richard J. BucalaChapter 10. Host Immunity to Human immunodeficiency Virus InfectionElijah PaintsilChapter 11. Fungal ImmunoepidemiologyMarwan M. AzarChapter 12. Immunoepidemiology of Plasmodium falciparum MalariaAmy K. Bei, Sunil ParikhChapter 13. Immunoepidemiology of CancerXiaomei Ma, Rong WangChapter 14. Modeling Approaches Toward Understanding Infectious Disease TransmissionLaura A. Skrip, Jeffrey P. TownsendChapter 15. VaccinesDiane McMahon-PrattChapter 16. Immunotherapy for Infectious Diseases, Cancer, and AutoimmunityPeter J. Krause, Paula B. Kavathas, Nancy H. RuddleAppendixJane O'Bryan, Kara Fikrig, Peter J. Krause, Kate Nyhan

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Book SynopsisThis textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.Table of ContentsSection I. Introduction​Chapter 1. Introduction to Immunology, Epidemiology, and ImmunoepidemiologyLinda Niccolai, Nancy H. Ruddle, and Peter J. KrauseChapter 2. Organization and Cells of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 3. Innate Immunity: Recognition and Effector FunctionsPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 4. Adaptive Immunity: Antigen Recognition by T and B LymphocytesPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 5 Adaptive Immunity: Effector Functions, Regulation, and VaccinationPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 6. Disorders of the Immune SystemPaula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhDChapter 7. Polymorphisms of Selected Components of the Innate and Adaptive Immune SystemsNancy H. Ruddle and Paula B. KavathasChapter 8. Immunoepidemiology of Immune DysfunctionEric Meffre, Peter J. Krause and Nancy H. RuddleChapter 9. Immunoepidemiology of Mycobacterium tuberculosisCamila D. Odio, Richard J. BucalaChapter 10. Host Immunity to Human immunodeficiency Virus InfectionElijah PaintsilChapter 11. Fungal ImmunoepidemiologyMarwan M. AzarChapter 12. Immunoepidemiology of Plasmodium falciparum MalariaAmy K. Bei, Sunil ParikhChapter 13. Immunoepidemiology of CancerXiaomei Ma, Rong WangChapter 14. Modeling Approaches Toward Understanding Infectious Disease TransmissionLaura A. Skrip, Jeffrey P. TownsendChapter 15. VaccinesDiane McMahon-PrattChapter 16. Immunotherapy for Infectious Diseases, Cancer, and AutoimmunityPeter J. Krause, Paula B. Kavathas, Nancy H. RuddleAppendixJane O'Bryan, Kara Fikrig, Peter J. Krause, Kate Nyhan

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Book SynopsisThis highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed.The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master- and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.Table of Contents

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Book SynopsisThis book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.Table of ContentsWhy the Spike protein is relevant for COVID19 therapeutics Whole genome mutation rates Phylogenetic systems Mechanism of immune escape: single nucleotide mutations, insertion/deletions, and recombination. Spike protein mutations detected in currently circulating strains. SARS-CoV-2 variants B.1.1.298 B.1.1.7 (alpha) B.1.351 (beta) B.1.1.28- and B.1.1.33-derived Brazilian variants (including gamma and zeta) B.1.525 (eta) B.1.526 (iota) B.1.427/B.1.429 (epsilon) B.1.617-derived variants (including kappa and delta) B.1.617.1 Delta VOC C.37 (lambda) P.3 (theta) Other variants under monitoring (VUM) Which strain will finally become dominant? SARS-CoV-2 variants characterization Predicting the functional consequences of mutations Efficacy of vaccines and monoclonal antibodies against SARS-CoV-2 variants Selective pressures exerted by antibody-based therapeutics

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Book SynopsisA brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design.- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV.- Human challenge studies with coronaviruses old and new.- Experimental urethral infection with Neisseria gonorrhoeae.- Helicobacter pylori.-Controlled human infection with Bordetella pertussisHuman challenge studies for cholera.- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.- Challenges in developing a controlled human tuberculosis challenge model.- Shigella Controlled Human Infection Models:  Current and Future Perspectives.- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella.- Controlled Human Malaria Infection studies in Africa - past, present, and future.- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.

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Book SynopsisAntimicrobial Peptides as Future Therapeutics: Challenges and Possibilities.- Bacterial antimicrobial peptides: A potential alternative to antibiotics.- Antimicrobial Peptide in oral health: A therapeutic approach.- Guardians of the Epidermis: Interplay between skin microbiota and antimicrobial peptides.-  Insect antimicrobial peptides in host-defense and their therapeutic application.- Herbal Antimicrobial Peptides: A Medicinal and Nutraceutical Approach.- Bioprocessing and market aspects of antimicrobial peptides.- Relationship between antimicrobial peptides, probiotics, postbiotics, and parabiotics in the Maintenance of a well-balanced gut ecosystem.- Strategic Defenders: Antimicrobial Peptides and their Impact on Innate Immunity.- Anti-microbial peptides from silkworm and their therapeutic application.- Harnessing Antimicrobial Peptides: A Key Defense against Emerging Respiratory Viral Diseases.- Antimicrobial peptides and their role against head and neck cancer.- Antimicrobial peptides in reproductive health and therapeutic applications.

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Book SynopsisThe biology of Dendritic cells-health and disease.- Innate lymphoid cells.- Primordial cells bridging the gap between innate and adaptive immunity.- Pattern recognition by NOD like receptors.- The C-type lectin receptors.- Collectins and Ficolins.- Complement system.- Innate immune response to viral infection.- Anti-fungal innate immune response.- Innate immune response to helminth infection.- Trained innate immunity.- Interactions between the innate and adaptive immune responses.- Role of innate immunity in cancer.- Innate immune mechanisms in normal and adverse pregnancy.- Innate immune mechanisms in the central nervous system.- Invertebrate innate immunity.- Pattern recognition and plant immunity.

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Book SynopsisThe dangerous decline in vaccinations in many developed countries is at the heart of a lively debate that confirms how important the subject is today. Vaccinations are among mankind’s most important scientific discoveries, yet they continue to be viewed with suspicion by part of the public – the victims of disinformation campaigns, instrumentalization and unfounded fears. There is, however, also an evolutionary explanation for these irrational beliefs, and countering the growing social opposition will be extremely difficult without grasping it. This book, which sheds new light on the safety and importance of vaccinations, is intended both for parents and those readers who want to understand the role of vaccinations in contemporary society, where the ease of access to knowledge is both a great opportunity and a great responsibility. The chapters follow a historical progression and conclude with a discussion of the most recent cognitive theories on how to overcome this opposition to vaccinations.Trade Review“The book covers what the author sees as the future of vaccines and even a section on effectively communicating resistance to the anti-vaccine trend. While the book is translated from Italian and includes many European examples, it also incorporates examples and citations from US and Canadian sources and remains relevant to an American audience. The extensive reference list could be useful for anyone studying this topic.” (C. A. Tomlinson, Choice, Vol. 56 (6), February, 2019)Table of Contents1. The parents of unvaccinated children 1.1. The 80s, the beginning of the crisis (or resistance) 1.2. Education about risk 1.3. Social changes: The doctor-patient relationship in jeopardy 1.4. Unexpected impact of late fecundity 2. A brief history of the anti-vaccination movements 2.1. The anti-vaccination movements between 1700 and 1800: Roots of obligation and objection 2.2. The anti-vaccination movements in 1900: Media and politics 3. Web alarms: autism, mercury and immune overload 3.1. Conspiracy on the Internet: separating fact from fiction 3.2. Economic criticism: Big Pharma and the allure of patents 3.3. Logic errors: the precautionary principle and the equal balance mistake 3.4. False or manipulated data: Autism 3.5. Prejudices and ideologies: Purported overload and weakening of the immune system <4. The antivax “experts": five ways to recognize them 4.1. Alternative philosophies: homeopathy, anthroposophy and Waldarf -Steiner schools 4.2. The "alternative therapies": Five clues that reveal a charlatan 5. Past, present, and future of vaccines 5.1. Evolutionary history of naturally acquired immunity 5.2. Artificially acquired immunity: success and safety of vaccines 5.3. Therapeutic vaccines of the future: cancer and neurodegenerative diseases 6. Conclusions 6.1. A new alliance between scientists and citizens for a “knowledge society” 6.2. Some tools for good communication strategies to combat anti-vaccination resistance

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