Description
Book SynopsisA brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design.- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV.- Human challenge studies with coronaviruses old and new.- Experimental urethral infection with Neisseria gonorrhoeae.- Helicobacter pylori.-Controlled human infection with Bordetella pertussis
Human challenge studies for cholera.- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.- Challenges in developing a controlled human tuberculosis challenge model.- Shigella Controlled Human Infection Models: Current and Future Perspectives.- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella.- Controlled Human Malaria Infection studies in Africa - past, present, and future.- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.
