Immunology Books

Book SynopsisThis book offers comprehensive information on all aspects of ELISA, starting with the fundamentals of the immune system. It also reviews the history of analytical assays prior to the advent of ELISA (enzyme-linked immunosorbent assay) and addresses the materials of choice for the fabrication of the platforms, possible biomolecular interactions, different protocols, and evaluation parameters. The book guides readers through the respective steps of the analytical assay, while also familiarizing them with the possible sources of error in the assay. It offers detailed insights into the immobilization techniques used for protein attachment, as well as methods for evaluating the assay and calculating the key parameters, such as sensitivity, specificity, accuracy and limit of detection. In addition, the book explores the advantages and shortcomings of the conventional ELISA, as well as various approaches to improving its performance. In this regard, merging and integrating other technologies with widely known ELISAs have opened new avenues for the advancement of this immunoassay. Accordingly, the book provides cutting-edge information on integrated platforms such as ELISpot, plasmonic ELISAs, sphere-/bead-based ELISAs, paper-/fiber-based ELISAs and ELISA in micro-devices. Table of Contents1 Fundamentals of ELISA: from the evolution of the immunoassays until invention of ELISAAbstract1. 1 Evolution of the immunoassays until invention of ELISA 1.1.1 Side chain theory1.1.2 Antigen-antibody binding theory1.1.3 Discovery of antibody structure1.1.4 Invention of RIA1.1.5 Invention and development of ELISA1.2 Principles of the immune system1.2.1 Antibody production in human body1.2.2 Categories of antibodies1.2.3 Antigen-antibody coupling1.2.4 Specificity of the antigen-antibody coupling1.3 Biomolecular interactions between antibody and antigen1.3.1 Hydrogen bonding1.3.2 Hydrophobic interaction1.3.3 Ionic attraction1.3.4 Van der Waals forces1.3.4.1 London dispersion1.3.4.2 Dipole-dipole interaction1.3.4.3 Ion-dipole forceReferences 2 General overview on applications of ELISAAbstract2.1 Application of ELISA2.1.1 Food industry2.1.2 Vaccine development2.1.3 Immunology2.1.3.1 Autoimmunity2.1.3.2 Humoral immunity2.1.4 Diagnosis2.1.4.1 Home pregnancy test2.1.4.2 Cancer detection2.1.4.3 Detection of the infectious diseases2.1.5 Toxicology 2.1.6 Drug monitoring and pharmaceutical industry2.1.7 TransplantationReferences 3 Step by step with ELISA: mechanism of operation, crucial elements, different protocols, and insights on immobilization and detection of various biomolecular entities Abstract3.1 Mechanism of operation3.2 Different elements of the assay3.2.1 Solid phase3.2.1.1 Adsorption3.2.2 Washing process3.2.3 Antigens 3.2.4 Antibodies3.2.4.1 Antispecies antibodies3.2.5 Enzyme3.2.5.2 Different types of enzyme3.2.5.2 Enzyme conjugation3.2.6 Substrate3.2.7 Stopping process3.2.8 Reading process3.2.8.1 Chromogenic assay3.2.8.2 Chemifluorescenct assay3.2.8.3 Chemiluminescent assay3.2.8.4 Reading apparatus3.2.9 Controls3.3 Target biomolecular entities by ELISA3.4 Different protocols3.4.1 Direct ELISA3.4.2 Indirect ELISA3.4.3 Sandwich ELISA3.4.4 Double sandwich ELISA3.4.5 Competitive ELISA3.5 Immobilization techniques for protein attachment 3.5.1 Physical immobilization3.5.2 Covalent immobilization3.5.2.1 Immobilization via zero-Length cross linker3.5.2.2 Immobilization via spacers3.5.3 Immobilization via entrapment3.5.4 Oriented immobilizationReferences 4 Evaluation of the detection results obtained from ELISAAbstract4.1 Conducting a reliable assay4.1.1 Sources of error4.1.2 Troubleshooting 4.2 Key parameters for evaluation of the assay4.2.1 Sensitivity4.2.2 Specificity4.2.3 Accuracy4.2.4 Limit of detection4.3 Measurable units in ELISAReferences 5 Advantages, disadvantages and modifications of conventional ELISA Abstract5.1 Significance of conventional ELISA 5.2 Shortages of conventional ELISA5.3 Materials of choice for fabrication of ELISA well plates5.4 Different types of ELISA well plates5.5 Modified ELISA platforms5.5.1 ELISpot5.5.2 Plasmonic ELISA5.5.3 Sphere-/bead-based ELISAs5.5.4 Paper-/fiber-based ELISAs5.5.5 ELISA in microdevicesReferences 6 Common questions and answers about ELISA AbstractReferences Summary

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Book SynopsisThis book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. Table of ContentsChapter 1. Obesity induced chronic low-level inflammation and cancers.- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers.- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation.- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer.- Chapter 6. Immune response and oxidative stress in obesity induced cancer.- Chapter 7. Role of gene polymorphism in obesity and cancer.- Chapter 8. Therapeutic role of green tea in obesity and cancer.- Chapter 9. Effect of dietary phytochemicals in obesity and cancer.- Chapter 10. Resveratrol as anti-obesity and anticancer agent.- Chapter 11. EGCG as anti-obesity and anticancer agent.- Chapter 12. miRNAs as therapeutic target in obesity and cancer.- Chapter 13. In silico updates on lead identification for obesity and cancer.- Chapter 14. In vivo models for obesity and obesity related carcinogenesis.- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases.- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.

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Book SynopsisThis book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.Table of ContentsSection 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis. Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment). Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains. Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes. Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level. Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes. Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites. Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes. Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes. Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes. Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes. Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research. Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites. Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters. Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production Chapter 18: Synthetic biology in Actinomycetes for natural product discovery Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.

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Book SynopsisThis book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.Table of Contents1 Cancer Metabolism and Aggressive Tumor Behaviour.- 2 Immune Cell Metabolism and Function.- 3 Cancer Cell Metabolism Effecting Immune function.- 4 Immune Cell Metabolites as Fuel for Cancer Cells.- 5 Immuno-Onco metabolism and Resistance to Therapy.- 6 Targeting Immuno-Onco metaolism in Cancers.- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.

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Book SynopsisThis book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.Table of ContentsChapter 1. Introduction to microRNAs and cancers.- Chapter 2. microRNAs and cancer signaling pathways.- Chapter 3. Role of microRNAs in cell growth proliferation and tumorigenesis.- Chapter 4. Impact of microRNAs in cell adhesion and tumor angiogenesis.- Chapter 5. Modulation of oxidative stress by microRNAs in cancers.- Chapter 6. microRNAs targeting tumor microenvironment and immune modulation.- Chapter 7. Circulating miRNA in prognosis, diagnosis and their role in controlling the fate of cancer stem cells.- Chapter 8. The role of miRNAs in the regulation of drug resistance among different cancers.- Chapter 9. The mechanisms of miRNA deregulation in cancer outbreak.- Chapter 10. Bioinformatic profiling of miRNAs in Cancers.

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Book SynopsisThis book provides valuable coverage on various immunomodulatory research associated with nutraceutical studies, from plant to animal and marine sources. The book focuses on the various properties of nutraceutical and functional foods, from dietary fibers to fungus, marine sources, ginseng, and several others. Its content is also dedicated to the nutraceutical potential and applications of these modulators. The first section of this book focuses mainly on the recent developments in nutraceutical and functional food associated with various immunomodulators. The next section covers the micronutrients and macronutrients level in order to share important data and help readers gain a basic understanding of the techno-functional, nutraceutical potential and applications of nutritional treatment under specific disease conditions. A detailed overview providing the structural and functional properties related to immunomodulators will be highly beneficial for academics and advanced-level students in immunology, food science, clinical medicine, and life sciences.Table of ContentsChapter 1. Nanotechnology based bacterial immunotherapy.- Chapter 2. Immunomodulatory properties of nutraceuticals and functional foods.- Chapter 3. Immunoregulatory bioactive phytoconstituents- recent trends and future challenges.- Chapter 4. Plant derived immunomodulators and immune system.- Chapter 5. Polyphenols and its effect on immune system.- Chapter 6. Mineral nutraceuticals and immunity enhancement.- Chapter 7. Nutraceuticals as disease preventive food and immunity boosters.- Chapter 8. Current and Future prospects of flavonoids for human Immune system.- Chapter 9. Resveratrol and immunomodulation.- Chapter 10. Immunomodulation impact of curcumin and its derivative as a natural ingredient.- Chapter 11. Colchicine and andrographolide as natural immunomodulators.- Chapter 12. Immune booster property of epigallocatechin-3-gallate and catechin.- Chapter 13. Recent advances of nutraceutical and functional foods in immune health.- Chapter 14.Therapeutic effects of Withania somnifera-an overview with special focus on Alzheimer’s disease and infertility among youth.

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Book SynopsisThis book illustrates the importance and significance of the systems approach in deciphering diverse aspects of host-parasite interactions in infection dynamics. It describes the complex issues and state-of-the-art progress in the infection biology of parasitic protozoa. The book explores the current concepts and paradigms of gene expression, metabolome, and immune remodeling in these diseases. The chapters encompass updates on the parasitic tropism, co-evolution, systemic responses in hosts, and translational approaches. It provides an overview of the parasite's efficient ways of exploiting host molecules and describes pathways for their survival, differentiation, and replication within the host cells. The book also delineates the role of inflammasomes and their activation in response to the protozoan parasite. The book discusses technological progress and machine learning-based modeling approaches to revisit parasitic infection from a non-conventional perspective. Collectively this book offers a comprehensive purview of concepts and paradigms in parasitic infection in the form of an updated yet discernible elucidation. ​Table of Contents1.Nanotechnology-based promising therapeutic approaches against protozoan.- 2. Intertwining of retinoic acid and cholesterol pathway and its consequences in Leishmania donovani infected macrophages.- 3. Role and pathophysiology of protozoan parasites causing liver diseases.- 4. Cognitive Impairment in Parasitic Protozoan Infection.- 5. Cycling Within a Cell: Cell Cycle of Intracellular Kinetoplastid Parasites.- 6. Elaborating role of aspartyl protease in host modulation and invasion in Apicomplexan parasites Plasmodium and Toxoplasma.- 7. Leishmaniasis: Tissue tropism in relation to the species diversity.- 8. Transcriptional control in Entamoeba: Something old, Something new.- 9. A perspective on mathematical modeling and machine learning models to predict Visceral Leishmaniasis.- 10. Elucidating the Role of miRNA in Inflammasome Mediated Immune Response in Leishmaniasis.- 11. An Insight into Immunopathology of Leishmaniasis. ​

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Book SynopsisThis book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. Table of Contents

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Book SynopsisThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Trade Review"This outstanding volume represents a review of the various effects of biopharmaceuticals and nanomedicines on the immune system: immunotherapy, vaccines, and drug delivery; challenges and overcoming translational barriers stemming from immunotoxicity; strategies to designing more immunologically friendly formulations." —África González-Fernández, PhD, MD, Professor of Immunology and President of the Spanish Society of Immunology, University of Vigo, Spain "For those who are specialists, and for those interested in a broader understanding of biologics and nanomedicines, this is a superb book, with internationally accomplished contributors. It serves both as a reference and as a practical guide to the newest advances in these important fields. Highly recommended!"—Carl R. Alving, MD, Emeritus Senior Scientist, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA "A skillfully produced book that addresses an often-missed topic: immune aspects of biologicals and nanoscale therapeutics, with an emphasis on clinical relevance and applications." —Rajiv R. Mohan, PhD, Professor and Ruth M. Kraeuchi Missouri Endowed Chair Professor, University of Missouri, Columbia, USA"An indispensable masterpiece! It represents a rich source of information on interactions of biologics and nanodrugs with the immune system—all critical for medical applications. Volume 3, once again, achieves the series’ high standards."—László Rosivall, MD, PhD, DSc Med, Med habil., Széchenyi Prize Laureate and Professor, Faculty of Medicine, Semmelweis University, Budapest, Hungary "Hats off to Dr. Bawa for producing yet another impressive volume in terms of scope, timeliness, and relevance. With expert contributions from around the globe, this book addresses topics germane to researchers, clinicians, drug and biotherapeutic companies, regulators, policymakers, and patients." —Sara Brenner, MD, MPH, Associate Professor and Assistant Vice President, SUNY Polytechnic Institute, Albany, New York, USA"Marvelous! This timely book shows clearly that while an immune reaction to "nano-exposure" is usually unwanted, the same response also bears an immense potential." —Silke Krol, PhD, IRCCS Istituto Tumori "Giovanni Paolo II" and Fondazione IRCCS Istituto Neurologico "Carlo Besta," ItalyThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Table of ContentsList of Corresponding Authors, Foreword, My Life with Biologicals and Nanodrugs: A Twenty-Year Affair, 1. Current Immune Aspects of Biologics and Nanodrugs: An Overview, 2. Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox, 3. Immunotherapy and Vaccines, 4. Site-Specific Antibody Conjugation for ADC and Beyond, 5. Current Understanding of Interactions between Nanoparticles and the Immune System, 6. Auto-antibodies as Biomarkers for Disease Diagnosis, 7. The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers, 8. Anti-PEG Immunity Against PEGylated Therapeutics, 9. Complement Activation: Challenges to Nanomedicine Development, 10. Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation, 11. Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols, 12. Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions, 13. Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms, 14. Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities, 15. Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA, 16. Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism, 17. Immunogenicity Assessment for Therapeutic Protein Products, 18. Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products, 19. The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System, 20. Immunotherapy for Gliomas and Other Intracranial Malignancies, 21. Engineering Nanoparticles to Overcome Barriers to Immunotherapy, 22. Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications, 23. Silica Nanoparticles Effects on Hemostasis, 24. Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia, 25. Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin, 26. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines, 27. Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation, 28. Unwanted Immunogenicity: From Risk Assessment to Risk Management, 29. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials, 30. SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy, Index

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Book SynopsisChapter 1_Overview of Inflammation.-Chapter 2_Risk factors associated with inflammation and management strategies.-Chapter 3_Cellular signalling in inflammation.-Chapter 4_Players of Inflammation in the Containment of Intracellular Infections.-Chapter 5_Regulation of T cell response in inflammation from killing to healing.-Chapter 6_Role of Inflammation in Tissue Regeneration and Repair.-Chapter 7_Inflammation and cancer.-Chapter 8_Inflammation resolution:  Future Prospects and advancements in technologies.-Chapter 9_Are multi-component drugs better in resolving the inflammation compared to the single component drugs? .- Chapter 10_Effect of ageing on Inflammation Resolution.- Chapter 11_Multi-omics data integration in understanding inflammation and inflammation resolution.- Chapter 12_Clinical trials and outcomes in anti-inflammatory therapies.- Chapter 13_Mechanistic understanding of in

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Book SynopsisChapter 1. Decoding Ubiquitin Modifications by Mass Spectrometry.- Chapter 2. Ubiquitination in the T Cell metabolism-based Immunotherapy in Diseases.- Chapter 3. Ubiquitination of Immune System and Cancer Therapy.- Chapter 4. Ubiquitination and Metabolic Disease.- Chapter 5. The Cullin-RING Ligase Family in Immune Regulation.- Chapter 6. The Immune Modulatory Role of TIF1 Proteins.- Chapter 7. Role of Ubiquitin Signaling in Modulating Dendritic Cell Function.- Chapter 8. Ubiquitin Signaling in the Immune System.- Chapter 9. Regulation of the Inflammasome Activation by Ubiquitination Machinery.- Chapter 10. The Function of Ubiquitination In T-Cell Development.

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Book SynopsisThe book also covers the immunopathology of various body systems, including lungs, reproductive system, enteric system, mammary gland, joints, kidneys, and skin.

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Book SynopsisChapter 1 Introduction to Immunology.- Chapter 2 The immune system.- Chapter 3 Innate immunity.-Chapter 4 Development, maturation and activation of T Lymphocytes.- Chapter 5 Development and maturation of B Lymphocytes.- Chapter 6 Antigens and antibodies.- Major Chapter 7 histocompatibility (MHC) and antigen presentation.- Chapter 8 Adaptive immunity and immune protection.- Chapter 9 Immunoregulation.- Chapter 10 Cytokines.- Chapter 11 The complement system.- Chapter 12 Hypersensitivity and autoimmune disease.- Chapter 13 Mucosal immunity and tolerance.- Chapter 14 Immunosuppression and immune escape

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Book Synopsis

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Book Synopsis

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