Genetics (non-medical) Books

Book SynopsisThis book is an overview of autism spectrum disorder (ASD), an early childhood condition that affects 1 in 68 children in the United States, and an estimated 1 to 2 percent of children worldwide. ASD causes impaired social skills, communication problems, and repetitive behaviors. The severity of ASD symptoms varies widely, ranging from mild effects with minimal impacts on functionality to severe effects that interfere with functionality and can prevent independent living. ASD is a complex trait disease caused by mutation of multiple ASD susceptibility genes, but it also occurs as part of monogenic genetic syndromes. Genetic testing for ASD is described in the book, and examples of ASD susceptibility genes. No treatments are available for the core symptoms of ASD, but the book describes therapies and drug treatments that can modulate them and address some of the health complications of ASD. The book presents new ASD biomarkers that can be used for better diagnosis and explores the hopeful prospect of personalized medicine for ASD.

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Book SynopsisThis book presents Down syndrome, which is the most common chromosomal disorder in humans, occurring at a rate of about 1 in 700 births. It describes the characteristic physical features caused by Down syndrome and the myriad of symptoms and health complications it brings, including heart defects, congenital vision and hearing loss, abnormalities of the musculoskeletal system, digestive problems, epilepsy, leukemia, an increased risk of infectious disease, dementia, and intellectual disability. Readers will learn about methods by which Down syndrome can be diagnosed prenatally or at birth, and the cause of Down syndrome as extra copies of the approximately 250 genes on chromosome 21. The book describes treatments and therapies for Down syndrome, and approaches to the education of children with it. Future prospects for the diagnosis and treatment of Down syndrome are presented, including experimental drugs, stem cell therapies, a process by which embryos produced in a clinical laboratory can be screened for Down syndrome before being used to establish a pregnancy, and several Down syndrome gene therapy strategies.

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Book SynopsisHemophilia is a genetic disease that impairs the normal process of blood clotting and results in uncontrolled external and internal bleeding. The reader of this book will learn how a diagnosis of hemophilia is made by blood clotting tests and measurements of clotting factor levels in blood. The book describes how hemophilia A and B are caused by mutations in genes that encode clotting factor VIII and clotting factor IX, respectively, both of which are carried on the X chromosome. As a result, almost all children born with hemophilia A and B are boys. Hemophilia C is caused by mutations in the clotting factor XI gene on chromosome 4, and occurs in males and females with equal frequency. The author details the use of factor replacement therapy to treat hemophilia, and evaluates the prospects for curing hemophilia through gene therapy and genome editing.

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Book SynopsisThis book describes Huntington's disease (HD), a rare neurodegenerative genetic disorder that causes a triad of motor, cognitive, and psychiatric/behavioral symptoms and affects about 6 in 100,000 people worldwide. Although the age of onset of HD symptoms is usually 30 to 50 years, a rare juvenile-onset form of HD also occurs. The autosomal dominant pattern of inheritance followed by HD is illustrated in the book with pedigree scenarios. The author details how mutations in the HTT gene on chromosome 4 cause HD and how a genetic test can be used by people who might have inherited adult-onset HD and couples who are at risk for passing HD on to their children. The book describes the available treatments for HD and presents new approaches such as experimental drugs, stem cell therapy, and gene therapy that might be able to effectively treat or even cure HD.

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Book SynopsisThis book presents muscular dystrophy (MD) as a group of genetic diseases with a worldwide occurrence of about 1 in 3,500 births that causes muscle wasting and weakening. It describes Duchenne MD as the most common type of MD, almost exclusively affecting males at a rate of about 1 in 5,000 boys, and eight rarer types of MD that are categorized by age of onset, muscles affected, disease progression, severity of symptoms, and health complications. The author describes how physical examination, muscle biopsy, medical imaging, and genetic testing is used to diagnose MD He further explains the underlying causes of the various types of MD as mutations in genes that encode proteins needed for the development, function, maintenance, and replacement of muscle cells and illustrates patterns by which they are inherited.There is no treatment that can reverse the progressive deterioration of muscles caused by MD, but the book offers insight into drug treatments and physical therapies that help maintain muscle strength and reduce health complications. It concludes with explanations of promising new ways to treat or perhaps cure MD, including experimental drugs, stem cell therapy, and gene therapy.

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Book SynopsisThis book describes newborn screening as a public health program for the early detection of genetic disorders. It presents the recommended uniform screening panel (RUSP), a list of genetic disorders recommended by the U.S. government for states to include in newborn screening programs. The author describes the categorization of RUSP genetic disorders, discusses the symptoms and health complications of examples from each category, and explains clinical laboratory tests used for newborn screening. The book explores the underlying molecular genetic causes of genetic disorders, and how this information is used for genetic testing during newborn screening and diagnosis. It presents the patterns of inheritance of monogenic genetic disorders, and uses hypothetical family scenarios to illustrate them. Treatments and therapies for selected RUSP genetic disorders are described that illustrate the benefits of early diagnosis. The book describes future prospects for the prevention, diagnosis, and treatment of genetic disorders detected by newborn screening, including experimental drug treatments, the possibility of newborn genome sequencing, and gene therapy.

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Book SynopsisThis book describes how obesity results from an imbalance between the intake of food energy and the expenditure of energy from physical activity and increases the risk of serious health problems including heart disease, stroke, osteoarthritis, and several types of cancer. Obesity is a global health problem that has reached epidemic levels. The worldwide prevalence of adult obesity is 13 percent of adults and 7 percent of children. The author explains how body mass index (BMI) can be used to screen for obesity, but that its diagnosis depends on clinical measurement of total body fat content and distribution. The book describes rare forms of obesity caused by a single gene or a genetic syndrome, and common obesity, a complex disease caused by multiple genetic and environmental risk factors. The book presents examples of obesity susceptibility genes and describes obesity genetic testing. It details how obesity can usually be treated with dietary changes, increased physical activity, and behavioral modification, but that people with extreme obesity or those who have serious health complications, require pharmaceutical or surgical interventions. Dr. Eckdahl discusses promising prospects for the treatment of obesity involving new pharmaceuticals, stem cell therapy, gene therapy, and fecal microbiota transplants.

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Book SynopsisThis book presents examples of hereditary blindness and deafness that illustrate the large variety of genetic diseases that affect vision and hearing. It describes seven hereditary eye diseases, three genetic syndromes that cause deafness, and four types of nonsyndromic deafness. The author explains the diagnosis of hereditary blindness and deafness in children and adults and describes the patterns of inheritance of blindness and deafness, illustrating each with family scenarios. The practice of genetic testing is described, which can provide information that prospective parents can use to make reproductive decisions. The text also presents treatments and therapies for hereditary blindness and deafness such as hearing aids, cochlear implants, and corneal implants. It describes future prospects for diagnosing, treating, and curing hereditary blindness and deafness, including experimental drugs, stem cell therapy, preimplantation genetic diagnosis, and gene therapy.

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Book SynopsisSickle cell disease (SCD) is the most common genetic blood disorder in the world. Millions of people in the world have SCD and about 300,000 babies are born with it each year. Readers will learn about the major symptoms of SCD, including chronic anemia, delayed growth, spleen dysfunction, opportunistic infections, vision loss, leg ulcers, stroke, and heart problems. The book explains how the primary cause of SCD is a gene mutation that causes hemoglobin to polymerize in red blood cells, making them adopt an abnormal sickle shape. Sickled cells carry less oxygen and occlude blood vessels in tissues and organs throughout the body. The reader will learn how SCD is inherited and how genetic testing can provide information that prospective parents can use to make reproductive decisions. The book presents treatments for SCD such as pain medications, antibiotic therapy, blood transfusions, and bone marrow transplantation. Future prospects for diagnosing, treating, and curing SCD are evaluated, including maternal blood screening, preimplantation genetic diagnosis, gene therapy, and genome editing.

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Book SynopsisInfectious diseases caused by bacteria and viruses exist in many forms and significantly affect human health. The sources of infectious diseases are vast, but in most cases arise from infectious microorganism such as bacteria or viruses that are able to establish growth or replication in humans, harming specific systems of the human body. This book introduces the reader to the basic differences between bacteria and viruses, particularly focusing on structures that contribute to the infectious properties of the microorganism. Chapters describe the cause, mode of transmission, symptoms, and treatments of five important diseases, taking into consideration the molecular interactions between host cells and infectious agents. Specifically, examples of viral infection (Influenza caused by the Influenza virus and hemorrhagic fever caused by the Ebola virus) and specific examples of bacterial infections (salmonellosis caused by Salmonella, gastrointestinal disease caused by Shiga-like toxin E. coli, and tuberculosis caused by Mycobacterium tuberculosis) are discussed in each chapter. The book ends with some future work related to treatment of these critical infectious diseases, noting the importance of drug resistance of infectious agents in treatment regimens.

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Book SynopsisIn life-threatening forms of cancer, cells stop working correctly, grow, divide, and spread throughout the body in harmful ways. These diseases impact the lives of many people, directly for those diagnosed and indirectly for the friends and families of those diagnosed. So many distinct forms of cancer with multiple unique diagnostic tools and approaches to treatment can be overwhelming for those diagnosed and those supporting them. Historical struggles with cancer can create a hopeless perception of disease prognosis, but advances in cancer diagnosis and treatment mean that many cancers can be well managed and even cured. This book discusses four types of cancer: skin, lung, breast, and prostate cancer. Wrestling with a diagnosis of one of these cancers can be complicated by the variety of treatment choices available and the unique medical history associated with both the patient and the cancer. The complexity of diagnosis and treatment requires that each cancer be considered a distinct disease, with some underlying common features. The author describes these common features and then discusses each cancer in terms of symptoms, diagnosis, causes, treatments, and future advances.

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Book SynopsisVector borne diseases transmitted through ticks and mosquitos cause serious loss of life and significantly impact human populations worldwide. Each of these diseases is caused by a distinct pathogen, and symptoms vary depending on the type and severity of infection. The spread of these diseases occur through the blood meals of tick or mosquitos, where the pathogen gains access to the human body, usually triggering an immune response that contributes to disease progression. Understanding the interdependence of pathogen to disease vector along with transmission route to humans shapes our diagnosis and treatment of these diseases. This book focuses on five distinct examples of vector borne disease: Malaria, West Nile, Lyme disease, dengue fever, and bubonic plaque. Malaria involves the mosquito vector and occurs when mosquito transmit the Plasmodium parasite to humans. West Nile and dengue fever also involve different mosquito vectors, but in this case transmission of the West Nile virus or dengue fever virus cause disease. Fleas transmit the bubonic plague causing bacterium Y. pestis. Lyme disease results from the transmission of the bacteria Borrelia burgdorferi to humans through the bit of a tick. In each case we consider current and future issues related to disease progression, diagnosis, and treatments.

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Book SynopsisAcquired immunodeficiency syndrome, or AIDS, is a disease of the immune system that is caused by the human immunodeficiency virus (HIV). AIDS has caused significant loss of life with considerable social and economic consequences worldwide. HIV must infect a host cell in order to replicate, and once infected, the host cell is unable to function properly. Since HIV infects specific cells of the host immune system, HIV infection impairs the ability of the patient to fight infections and kill cancer cells, therefore most deaths associated with HIV infection occur due to cancer or opportunistic infections. There is no cure for HIV, but advancements in treatments mean that an HIV positive person could experience a normal lifespan with sustained daily care and medication designed to prevent HIV replication and spread. These medications primarily target viral proteins that allow HIV to infect host cells, replicate, and spread in the body. Work continues to find a way to eliminate HIV from patients and develop new pharmaceutical targets to address concerns of drug resistant strains of HIV. Worldwide awareness of how the virus infects, is treated, and spreads within populations is a critical component to control the current AIDS pandemic.

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Book SynopsisVaccinations provide an effective way to prevent fatal diseases or reduce their symptoms. This book highlights four infectious diseases: polio, tetanus, measles, and mumps. These four diseases are very harmful to human health and are difficult to treat after the infection because they are caused by a toxin or pathogenic virus. In all four cases, the disease exhibits different modes of transmission and progression of symptoms, which require unique treatment regimens. However, all cases can be prevented by vaccinations administered prior to infection.This book summarizes the symptoms and disease progression of all the four diseases and provides information about the toxin or virus that causes each disease. The ability to harness our immune system through vaccination is discussed in the context of disease prevention. Minor and infrequent risks associated with vaccination are also described, but the very dangerous misconception that vaccines cause autism or other major illnesses is strongly refuted.

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Book SynopsisThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.Table of Contents1 Genes and chromatin1.1 Central dogma of molecular biology1.2 Impact of chromatin structure1.3 Epigenetics enables gene expression1.4 Gene regulation in the context of nuclear architecture2 Basal transcriptional machinery2.1 Core promoter2.2 TATA box and other core promoter elements2.3 Genome-wide core promoter identification2.4 TFIID and Mediator as paradigms of multi-protein complexes3 Transcription factors and signal transduction3.1 Site-specific transcription factors and their domains3.2 Classification of transcription factors3.3. Activation of transcription factors3.4 Programing cellular differentiation by transcription factors3.5 Inflammatory signaling via NF-B3.6 Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors4.1 The nuclear receptor superfamily4.2 Molecular interactions of nuclear receptors4.3 Physiological role of nuclear receptors5 Genome-wide principles of gene regulation5.1 Next-generation sequencing5.2 Gene regulation in the context of Big Biology5.3 Exploring genome-wide transcription factor binding5.4 Integrating epigenome-wide datasets6 Chromatin modifiers6.1 Cytosines and their methylation6.2 Histone modifications6.3 Gene regulation via chromatin modifiers6.4 Sensing energy metabolism via chromatin modifiers7 Epigenetics7.1 Epigenetics and chromatin7.2 Genome-wide understanding of epigenetics7.3 CTCF and genetic imprinting7.4 Epigenetics in health and disease8 Chromatin remodeling and organization8.1 Nucleosome positioning at promoters8.2 Chromatin remodeling8.3 Transcriptional dynamics in the presence of chromatin8.4 Organization of the nucleus9 Regulatory impact of non-coding RNA9.1 Non-coding RNAs9.2 miRNAs and their regulatory potential9.3 Long ncRNAs9.4 Enhancer RNAs

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Book SynopsisMicrobiome research has focused on microorganisms that live within the human body and their effects on health. During the last few years, the quantification of microbiome composition in different environments has been facilitated by the advent of high throughput sequencing technologies. The statistical challenges include computational difficulties due to the high volume of data; normalization and quantification of metabolic abundances, relative taxa and bacterial genes; high-dimensionality; multivariate analysis; the inherently compositional nature of the data; and the proper utilization of complementary phylogenetic information. This has resulted in an explosion of statistical approaches aimed at tackling the unique opportunities and challenges presented by microbiome data. This book provides a comprehensive overview of the state of the art in statistical and informatics technologies for microbiome research. In addition to reviewing demonstrably successful cutting-edge methods, particular emphasis is placed on examples in R that rely on available statistical packages for microbiome data. With its wide-ranging approach, the book benefits not only trained statisticians in academia and industry involved in microbiome research, but also other scientists working in microbiomics and in related fields.Table of Contents1. Tree-guided regression and multivariate analysis of microbiome data - Hongu Zhao and Tao Wang.- 2. Computational methods for metagenomic assemblies and strain identification - Hongzhe Li.- 3. Graphical models for microbiome data - Ali Shojaie.- 4. Bayesian models for understanding the modulating factors of microbiome data - Francesco Denti, Matthew D. Koslovsky, Michele Guindani, Marina Vannucci, and Katrine L. Whiteson.- 5. Use of variable importance in microbiome studies - Hemant Ishwaran.- 6. Log-linear models for microbiome data - Glen Satten.- 7. Quantification of amplicon sequences in microbiome samples using statistical methods - Karin Dorman.- 8. TBD - Jeanine Houwing Duistermaat.- 9. Analyzing microbiome data by employing the power of abundance ratios - Zhigang Li.- 10. Beta diversity analysis - Michael Wu.- 11. MicroPro: using metagenomic unmapped reads to provide insights into human microbiota and disease associations - Fengzhu Sun.- 12. Statistical methods for feature selection in microbiome studies - Peng Liu.- 13. A Bayesian restoration of the duality between principal components of a distance matrix and operational taxonomic units in microbiome analyses - Somnath Datta and Subharup Guha.

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Book SynopsisThis book is the first comprehensive compilation of deliberations on whole genome sequencing of the diploid and tetraploid alfalfa genomes including sequence assembly, gene annotation, and comparative genomics with the model legume genome, functional genomics, and genomics of important agronomic characters. Other chapters describe the genetic diversity and germplasm collections of alfalfa, as well as development of genetic markers and genome-wide association and genomic selection for economical important traits, genome editing, genomics, and breeding targets to address current and future needs. Altogether, the book contains about 300 pages over 16 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers, and scientists in the academia and relevant private companies interested in genetics, breeding, pathology, physiology, molecular genetics and breeding, biotechnology, and structural and functional genomics. The work is also useful to seed and forage industries.Table of Contents

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Book SynopsisDemand for agricultural crops and nutritional requirement continues to escalate in response to increasing population. Also, climate change exerts adverse effects on agriculture crop productivity. Plant researchers have, therefore, focused to identify the scientific approaches that minimize the negative impacts of climate change on agricultural crops. Thus, it is the need of the hour to expedite the process for improving stress tolerance mechanisms in agricultural crops against various environmental factors, in order to fulfil the world’s food demand. Among the various applied approaches, the application of phytohormones has gained significant attention in inducing stress tolerance mechanisms.Jasmonates are phytohormones with ubiquitous distribution among plants and generally considered to modulate many physiological events in higher plants such as defence responses, flowering and senescence. Also, jasmonates mediate plant responses to many biotic and abiotic stresses by triggering a transcriptional reprogramming that allows cells to cope with pathogens and stresses. Likewise, salicylates are important signal molecules for modulating plant responses to environmental stresses. Salicylic acid influences a range of diverse processes in plants, including seed germination, stomatal closure, ion uptake and transport, membrane permeability and photosynthetic and growth rate.Understanding the significant roles of these phytohormones in plant biology and from agriculture point of view, the current subject has recently attracted the attention of scientists from across the globe. Therefore, we bring forth a comprehensive book “Jasmonates and Salicylates Signalling in Plants” highlighting the various prospects involved in the current scenario. The book comprises chapters from diverse areas dealing with biotechnology, molecular biology, proteomics, genomics, metabolomics, etc. We are hopeful that this comprehensive book furnishes the requisite of all those who are working or have interest in this topic.Table of ContentsChapter 01Jasmonates and Salicylates: Mechanisms, Transport and Signalling during Abiotic Stress in PlantsAkbar Hossain1,*, Zahoor Ahmad2, Debjyoti Moulik3, Sagar Maitra4, Preetha Bhadra5, Adeel Ahmad6, Sourav Garai7, Mousumi Mondal7, Anirban Roy8, Ayman El Sabagh9,10, Tariq Aftab11Chapter 02Salicylic acid and jasmonic acid in generating salt stress tolerant plantsAnkur Singh, Aryadeep Roychoudhury*Chapter 03Role of Jasmonic and Salicylic acid signaling in plants under UV-B stressKrishna Kumar Choudhary1, Suruchi Singh2, Madhoolika Agrawal3 and S. B. Agrawal3*Chapter 04Plant Responses to Exogenous Salicylic and Jasmonic Acids under Drought StressKazem Ghassemi-Golezani1*, Salar Farhangi-Abriz2Chapter 05Role of jasmonic acid and salicylic acid signaling in secondary metabolite production Samapika Nandy, Tuylee Das, Abhijit Dey*Chapter 06Role of jasmonates and salicylates in plant allelopathyAnam Asif1, Mohammad Affan Baig2*, M. Badruzzaman Siddiqui1Chapter 07Jasmonate: A versatile messenger in plantsPriyanka Singh, Yamshi Arif, Husna Siddiqui and Shamsul Hayat*Chapter 08The crucial role of jasmonates in enhancing heavy metals tolerance in plantsAli Raza1*, Sidra Charagh2, Shiva Najafi Kakavand3,4, Manzer H. Siddiqui5Chapter 09Jasmonates: The Fine-Tuning Bio-Regulators and their Crosstalk with Plant Reproductive BiologyDeepu Pandita*Chapter 10Role of Jasmonates in pathogenesis and crosstalk of Jasmonates with other hormonesShreshtha Yadav1, Simran1, Nisha Sella1, Shabir A. Rather2*Chapter 11Methyl Jasmonate and its Application for Improving Postharvest Quality of Fruits Deep Lata1, Anusree Anand1, Burhan Ozturk2, Riadh Ilahy3 , Md. Shamsher Ahmad4, and Mohammed Wasim Siddiqui4*Chapter 12Salicylic acid signalling under stress conditions in plantsTibor Janda*, Kinga O. Gondor, Magda Pál, Gabriella SzalaiChapter 13Function of Mediator in regulating salicylic acid mediated signaling and responses in plantsShubham Kumar Sinha, Koppolu Raja Rajesh Kumar*Chapter 14The Hidden Pathways Affecting Salicylic Acid Signaling in PlantsBahareh Hekmatdoust Tabrizi1, Neda Fattahi1, Rachel Backer2, Zahra Dehghanian3, Khosro Balilashaki4, Behnam Asgari Lajayer5*, and Tess Astatkie6 Chapter 15Salicylic Acid (SA): Its interaction with different molecules in the stress tolerance signaling pathwaysAparna Pandey1, Nidhi Verma1, Shikha Singh1, Gausiya Bashri2 and Sheo Mohan Prasad1*

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Book SynopsisThis book serves as the first comprehensive compilation describing the breeding strategies and genetics and genomics of the coconut palm. It describes gene evolution of economically important traits such as oil biosynthesis, aroma and fragrance, disease-resistant genes and small RNAs-mediated gene regulation of coconut. Application of “omics” approaches in palms and the prospects of genome editing technologies in coconut are also discussed. The author list includes pioneers and experts in the field of coconut genomics. The book appeals to postgraduate students, researchers and industry players in the field of plantation crops in general and coconut in particular.Table of ContentsChapter 1. World Economic Importance.- Chapter 2. Botanical Study and Cytology.- Chapter 3. Germplasm Resources: Diversity and Conservation.- Chapter 4. Breeding Strategies.- Chapter 5. Characterization of Genetic Diversity Using Molecular Markers.- Chapter 6. Quantitative Trait Loci (QTL) and Association Mapping for Major Agronomic Traits.- Chapter 7. Palms in an ‘OMICS’ Era.- Chapter 8. Genome Sequencing, Transcriptomics, Proteomics and Metabolomics.- Chapter 9. Mitochondrial and Chloroplast Genomes.- Chapter 10. Endosperm Oil Biosynthesis: A Case Study for Trait Related Gene Evolution in Coconut.- Chapter 11. Aroma and Fragrance: A Case Study for Trait-Related Gene Evolution in Coconut.- Chapter 12. Resistance Gene Candidates (RGCs) in Coconut Palm: A Molecular Platform for the Genetic Improvement of Resistance to Pathogens.- Chapter 13. Epigenetics of Coconut Endosperm Development.- Chapter 14. Genome Editing: Prospects and Challenges.- Chapter 15. Coconut: The Tree Of Life- Endless Possibilities.

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Book SynopsisThis book serves as the first comprehensive compilation describing the breeding strategies and genetics and genomics of the coconut palm. It describes gene evolution of economically important traits such as oil biosynthesis, aroma and fragrance, disease-resistant genes and small RNAs-mediated gene regulation of coconut. Application of “omics” approaches in palms and the prospects of genome editing technologies in coconut are also discussed. The author list includes pioneers and experts in the field of coconut genomics. The book appeals to postgraduate students, researchers and industry players in the field of plantation crops in general and coconut in particular.Table of ContentsChapter 1. World Economic Importance.- Chapter 2. Botanical Study and Cytology.- Chapter 3. Germplasm Resources: Diversity and Conservation.- Chapter 4. Breeding Strategies.- Chapter 5. Characterization of Genetic Diversity Using Molecular Markers.- Chapter 6. Quantitative Trait Loci (QTL) and Association Mapping for Major Agronomic Traits.- Chapter 7. Palms in an ‘OMICS’ Era.- Chapter 8. Genome Sequencing, Transcriptomics, Proteomics and Metabolomics.- Chapter 9. Mitochondrial and Chloroplast Genomes.- Chapter 10. Endosperm Oil Biosynthesis: A Case Study for Trait Related Gene Evolution in Coconut.- Chapter 11. Aroma and Fragrance: A Case Study for Trait-Related Gene Evolution in Coconut.- Chapter 12. Resistance Gene Candidates (RGCs) in Coconut Palm: A Molecular Platform for the Genetic Improvement of Resistance to Pathogens.- Chapter 13. Epigenetics of Coconut Endosperm Development.- Chapter 14. Genome Editing: Prospects and Challenges.- Chapter 15. Coconut: The Tree Of Life- Endless Possibilities.

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Book SynopsisThis book is the first comprehensive compilation of knowledge on teak biology, ecology, clonal forestry, clonal registration, seed biology, and seed orchards. The teak genetic diversity, the sequenced genome, and transcriptomes from different tissues and their implications in modern tree improvement and material selection have been comprehensively discussed. The book also presents a narrative on wood characterization, wood chemistry, modern silviculture, growth and modelling, and economics of this valued tropical species. Altogether, the book contains about 200 pages over 16 chapters authored by globally reputed experts on the relevant field in this tropical tree. This book is useful to students, teachers, and scientists, and wood-based industries are interested in forestry, biology, seed orchards, breeding, genetic diversity, molecular genetics, in vitro culture, wood chemistry, and structural and functional genomics.Table of Contents

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Book SynopsisThis book provides updated and all-inclusive data and evidences for Moringa botany, cytogenetical analysis, genetic resources and diversity, classical genetics, traditional breeding, tissue culture, genetic transformation, whole-genome sequencing, comparative genomics and elucidation on applications of functional genomics, nanotechnology, bioinformatics, processing and value addition besides providing perspectives of medicinal and therapeutic properties of Moringa. Moringa gained global attention in the recent past owing to its unique blend of affordable nutraceutical and pharmaceutical compounds in all parts of the plants. Scientific literatures supporting its health benefits besides the studies on its utility in various fields are scattered on several reports. This book is written by renowned global subject experts by compiling and narrating it in a sober style.Table of Contents

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Book SynopsisThis book is the first comprehensive compilation of the most up-to-date research in the genomics, transcriptomics, and breeding of pine species across Europe, North America, and Australia. With chapters on the state of the reference genomes, transposon function, genome-wide diversity, functional genomics, genomics of disease resistance, genomics of abiotic stress, and genomic selection, this book is a must-read for scientists, breeders, and students of plant genomics. The book contains 12 chapters over 300 pages authored by a group of world-renowned scientists in the field of pine genomics. Pines (Pinus) are the world’s most economically important forest tree species. The recent genome sequencing of several important pine species has paved the way for understanding their complex biology and helps future management and breeding efforts.Table of Contents

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Book SynopsisThis thorough introductory volume presents the background, applications, and stepwise directions for standard DNA and RNA isolation techniques. Unlike a kit chemistry approach, this book provides a breadth of information necessary for junior or non-expert researchers to learn and apply these techniques in their work. An accessible, indispensable how-to guide for researchers in immunology, molecular biology, zoology, forensic science, genetics, botany, neuroscience, physiology, and others.Table of Contents1-Basic idea about nucleic acids for non-experts 2-General steps during isolation of DNA and RNA 3-Phenol-chloroform DNA isolation method 4-RNA isolation by the guanidinium-acid-phenol method 5-Spin column-based isolation of nucleic acid 6-Isolation of plasmid DNA by alkaline lysis 7-DNA Isolation by Hydrophilic Ionic Liquid Treatment 8-Lithium Chloride based isolation of DNA and RNA 9-Isolation of Bacteriophage DNA by PEG Method 10-DNA isolation by Chelex Method 11-DNA isolation by Lysozyme and Proteinase K 12-Salting-out method for blood samples 13-CTAB or SDS based isolation of plant’s DNA 14-DNA extraction by spooling method 15-Magnetic bead-based nucleic acid isolation 16-Density gradient-based nucleic acid isolation 17-DNA extraction from agarose gel though paper-strips 18-TRANSFORMATION OR GENETIC MODIFICATION OF CELLS/ORGANISMS 19-GENE CLONING AND VECTORS 20-POLYMERASE CHAIN REACTION (PCR) 21-Southern and Northern Blotting 22-GENOME MAPPING 23-Applications of DNA Sequencing Technologies for Current Research

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Book SynopsisThis book presents deliberations on molecular and genomic mechanisms underlying the interactions of crop plants to the abiotic stresses caused by heat, cold, drought, flooding, submergence, salinity, acidity, etc., important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomic-assisted breeding, and the recently emerging genome editing for developing resistant varieties in vegetable crops is imperative for addressing FHNEE (food, health, nutrition, energy, and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing has provided precise information regarding the genes conferring resistance useful for gene discovery, allele mining, and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to abiotic stresses.The nine chapters each dedicated to a vegetable crop or crop group in this volume elucidate on different types of abiotic stresses and their effects on and interaction with the crop; enumerate on the available genetic diversity with regard to abiotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; present brief on classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; depict the success stories of genetic engineering for developing abiotic stress-resistant crop varieties; discuss on molecular mapping of genes and QTLs underlying stress resistance and their marker-assisted introgression into elite varieties; enunciate on different genomics-aided techniques including genomic selection, allele mining, gene discovery, and gene pyramiding for developing adaptive crop varieties with higher quantity and quality of yields, and also elaborate some case studies on genome editing focusing on specific genes for generating abiotic stress-resistant cropsTable of ContentsSee attached Proposal Form, which includes ToC.

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Book SynopsisThis open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production. Table of ContentsChapter 1. IntroductionPart I. The Diversity of GenomicsChapter 2. Distributed and Concentrated Strategies in the Sequencing of the Yeast GenomeChapter 3. The Human Genome Project(s)Part II. Communities and Reference GenomesChapter 4. The Funnelling Effect of the Sanger InstituteChapter 5. The Pig Community and Their Reference GenomePart III. Contextualising and Enhancing Reference GenomesChapter 6. Making Reference Genomes Useful: AnnotationChapter 7. Improving and Going Beyond Reference GenomesChapter 8. Conclusion

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Book SynopsisThis book constitutes the refereed proceedings of the 19th Annual RECOMB Satellite Workshop on Comparative Genomics, RECOMB-CG which took place in La Jolla, USA, during May 20-21, 2022. The 18 full papers included in this book were carefully reviewed and selected from 28 submissions. The papers were organized in topical sections on evolution; phylogenetics; homology and reconciliation; genome rearrangements; metagenomics; and genomic sequencing. Table of ContentsEvolution.- On the Comparison of Bacteriophage Populations.- Syntenic Dimensions of Genomic Evolution.- Phylogenetics.- Fast and Accurate Branch Support Calculation for Distance-based Phylogenetic Placements.- The Sackin Index of Simplex Networks.- Phylogenetic Placement Problem: A Hyperbolic Embedding Approach.- Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account.- Homology and Reconciliation.- The Complexity of Finding Common Partitions of Genomes with Predefined Block Sizes.- Reconciliation with Segmental Duplication, Transfer, Loss and Gain.- Quantifying Hierarchical Conflicts in Homology Statements.- On Partial Gene Transfer and its Impact on Gene Tree Reconstruction.- Genome Rearrangements.- Sorting by k-Cuts on Signed Permutations.- A New Approach for the Reversal Distance with Indels and Moves in Intergenic Regions.- Chromothripsis Rearrangements Are Informed by 3D Genome Organization.- Metagenomics.- Using Computational Synthetic Biology Tools to Modulate Gene Expression within a Microbiome.- Metagenomics Binning of Long Reads Using Read-Overlap Graphs.- A Mixed Integer Linear Programming Algorithm for Plasmid Binning.- Genomic Sequencing.- Benchmarking Penalized Regression Methods in Machine Learning for Single Cell RNA Sequencing Data.- Deciphering the Tissue-speci c Regulatory Role of Intronless Genes Across Cancers.

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Book SynopsisOver the last few decades, various techniques have been developed to alter the properties of plants and animals. While the targeted transfer of recombinant DNA into crop plants remains a valuable tool to achieve a desirable breeding outcome, integration of transgenes into the host genome has been random, which in part, leads to reduced acceptance of GMOs by the general population in some parts of the world. Likewise, methods of induced mutagenesis, such as TILLING, have the disadvantage that many mutations are induced per plant, which has to be removed again by expensive backcrossing. Advances in genome sequencing have provided more and more information on differences between susceptible and resistant varieties, which can now be directly targeted and modified using CRISPR/Cas9 technology. By selecting specific gRNAs occurrence of off-target modifications are comparatively low. ZFNs and TALENs- based approaches required re-engineering a new set of assembled polypeptides for every new target site for each experiment. The difficulty in cloning and protein engineering prevented these tools from being broadly adopted by the scientific community. Compared to these technologies, designing the CRISPR toolbox is much simpler and more flexible. CRISPR/Cas9 is versatile, less expensive and highly efficient. It has become the most widely used technology for genome editing in many organisms.Since its inception as a powerful genome-editing tool in late 2012, this breakthrough technology has completely changed how science is performed. The first few chapters in this book introduce the basic concept, design and implementation of CRISPR/Cas9 for different plant systems. They are followed by in-depth discussions on the legal and bio-safety issues accompanying commercialization and patenting of this emerging technology. Lastly, this book covers emerging areas of new tools and potential applications. We believe readers, novice and expert alike, will benefit from this all-in-one resource on genome editing for crop improvement.Chapter 17 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of Contents S.No Tentative Chapter Title Author Details Genome engineering as a tool for enhancing crop traits: Lessons from CRISPR/Cas9 Tariq Shah and Aziz Khan* College of Agriculture, Guangxi University, Nanning, China Email: azizkhanturlandi@gmail.com Commercialization of CRISPR derived Crops: Current Status and future prospects Dr. Martin A Lema Universidad Nacional de Quilmes, Roque Sáenz Peña 180, B1876BXD Bernal, Buenos Aires, Argentina. Email: mlema@unq.edu.ar Targeted allele recombination for precise mapping in plant breeding Dr. Eyal Fridman Department of vegetables and field crops, Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7505101, Israel Email: fridmane@volcani.agri.gov.il Hindex: 28 Applications of gene drive for weeds and pest management using CRISPR/CAS9 system in plants Dr. Kathleen Hefferon Food Science and Technology, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA Email: klh22@cornell.edu Hindex: 14 Genome editing by Ribonucleorotein based delivery of CAS9 system in plants Karina Morales, Michael J. Thomson Professor and HM Beachell Endowed Chair in International Rice Improvement Dept. of Soil and Crop Sciences, Texas A&M University / Texas A&M AgriLife Research 370 Olsen Blvd., 2474 TAMU, College Station, TX 77843-2474 Email: email: m.thomson@tamu.edu Hindex: 28 Virus mediated delivery of CRISPR/CAS9 system in plants Dr. Monika Bansal, Women scientist-A (completed) School of Agricultural biotechnology, Punjab Agricultural university, Ludhiana Dr. Shabir Hussain Wani Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, J&K, India Email:shabirhwani@skuastkashmir.ac.in Hindex: 24 Epigenetic and chromosomal Rearrangements in genome editing Neha Goel (Ph.D.) Genetics and Tree Improvement Forest Research Institute, Dehradun Email:goelneha6@gmail.con Dr. Shabir Hussain Wani Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, J&K, India Email:shabirhwani@skuastkashmir.ac.in Hindex: 24 Multiplexed genome editing in plants for improvement of various traits using CRISPR/CAS9 based system Dr. Goetz Hensel Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Plant Reproductive Biology Corrensstr. 3 D-06466 Seeland/OT Gatersleben GERMANY Email: hensel@ipk-gatersleben.de Hindex: 33 Application of CRISPR CAS9 for regulation of epigenetic traits in plants Abdullah Makhzoum Department of Biological Sciences and Biotechnology, Botswana International University of Science and Technology, Palapye, Botswana; Correspondenceabmakhzoum@gmail.com Hindex: 10 New Cas9 Variants and other nucleases broadening the scope of CRISPR Toolbox Dr. Goetz Hensel Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Plant Reproductive Biology Corrensstr. 3 D-06466 Seeland/OT Gatersleben GERMANY Email: hensel@ipk-gatersleben.de Hindex: 33 Transgene free genome editing in plants using CRISPR/CAS9 Dr. Niaz Ahmad Dr. Penny Hundleby Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK Email: penny.hundleby@jic.ac.uk Prof. Mehboob Rahman Group Leader Plant genomics & Mol. Breeding Lab, National Institute for Biotechnology & Genetic Engineering (NIBGE), PO Box 577, Jhang Road, Faisalabad, Pakistan. Email: mehboob_pbd@yahoo.com H index 23 Genome editing in plants for improvement of resistance in plants against fungal and viral pathogens Dr. Kathleen Hefferon Food Science and Technology, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA Email: klh22@cornell.edu H index 14 Characterization of gene edited crops via metabolomics. Dr. Muhammad Qudrat Ullah Farooqi School of Agriculture and Environment; Faculty of Science The University of Western Australia, Perth WA 6009 Australia Email: muhammadqudratullah.farooqi@uwa.edu.au Genome editing in plants for improvement of resistance in plants against bacterial pathogen Dr. Rajesh Mehrotra Birla Institute of Technology and Science (BITS-Pilani), Rahashthan, India Email: rmehrotra@pilani.bits-pilani.ac.in Dr. Purvalohan Bhalothia Email: purvalohan@gmail.com H index 16 Improvement of resistance in plants against Insect-pest using genome editing tools Dr Sandeep Kumar, Assistant Professor, Department of Zoology, KU SSJ Campus, Almora, Uttarakhand,India Email: sandeep.ento@gmail.com Comparing the efficiency of different delivery methods of CRISPR/CAS9 toolkits into plants Dr Ananda Sarkar National Institute of Plant Genome Research (NIPGR), Jawaharlal Nehru University Campus, Aruna Asaf Ali Marg, New Delhi, Delhi, 110067, India Email:aksarkar@nipgr.ac.in Hindex 17 Recent trends in targeting genome editing of tomato for abiotic stress tolerance Dr. P. Hima Kumari, Jawaharlal Nehru Technological University, Hyderabad, 500085 phimakumari@gmail.com Genome editing approaches for improving nitrogen use efficiency and deciphering mineral nutrient homeostasis Viswanathan Chinnusamy Principal Scientist & Head Division of Plant Physiology ICAR-Indian Agricultural Research Institute, New Delhi, India Email: viswa_iari@hotmail.com Hindex : 37 Recent advances and application of CRISPR base editors for improvement of various traits in crops Dr Seema Pradhan and Dr Ajay Parida, Director, Institute of Life Sciences, Bhubaneswar, India Email: drajayparida@gmail.com, director@ils.res.in Dr. Seema Pradhan Email: seemapradhan3@gmail.com CRISPR/Cas9-mediated targeted mutagenesis in medicinal plants Dr. Rohit Joshi Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India Email: joshirohit6@gmail.com H-index: 17 Biosafety issue related to genome editing in plants using CRISPR-Cas9 Dr. Ramesh Katam Department of Biological Sciences, Florida A&M University, Tallahassee, FL 32307, USA Email: ramesh.katam@gmail.com 22 IPR and regulatory issues in Genome editing in plants. Dimple Sharma Plant and Soil Science department Texas Tech University, USA Email: dimple.sharma@ttu.edu

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Book SynopsisAccess to food with enough calories and nutrients is a fundamental right of every human. The global population has exceeded 7.8 billion and is expected to pass 10 billion by 2055. Such rapid population increase presents a great challenge for food supply. More grain production is needed to provide basic calories for humans. Thus, it is crucial to produce 60-110% more food to fill the gap between food production and the demand of future generations.Meanwhile food nutritional values are of increasing interest to accommodate industrialized modern lives. The instability of food production caused by global climate change presents another great challenge. The global warming rate has become more rapid in recent decades, with more frequent extreme climate change including higher temperatures, drought, and floods. Our world faces various unprecedented scenarios such as rising temperatures, which causes melting glaciers and the resulting various biotic and abiotic stresses, ultimately leading to food scarcity. In these circumstances it is of utmost importance to examine the genetic basis and extensive utilization of germplasm to develop “climate resilient cultivars” through the application of plant breeding and biotechnological tools. Future crops must adapt to these new and unpredictable environments. Crop varieties resistant to biotic and abiotic stresses are also needed as plant disease, insects, drought, high- and low-temperature stresses are expected to be impacted by climate change. Thus, we need a food production system that can simultaneously satisfy societal demands and long-term development.Since the Green Revolution in the 1960s, farming has been heavily dependent on high input of nitrogen and pesticides. This leads to environmental pollution which is not sustainable in the long run. Therefore, a new breeding scheme is urgently needed to enable sustainable agriculture; including new strategies to develop varieties and crops that have high yield potential, high yield stability, and superior grain quality and nutrition while also using less consumption of water, fertilizer, and chemicals in light of environmental protection. While we face these challenges, we also have great opportunities, especially with flourishing developments in omics technologies. High-quality reference genomes are becoming available for a larger number of species, with some species having more than one reference genome. The genome-wide re-sequencing of diverse varieties enables the identification of core- and pan-genomes. An integration of omics data will enable a rapid and high-throughput identification of many genes simultaneously for a relevant trait. This will change our current research paradigm fundamentally from single gene analysis to pathway or network analysis. This will also expand our understanding of crop domestication and improvement. In addition, with the knowledge gained from omics data, in combination with new technologies like targeted gene editing, we can breed new varieties and crops for sustainable agriculture.Table of ContentsChapter. 1. The utilization of speed breeding and genome editing to achieve zero hungerChapter. 2. Multiomics approach for crop improvement under climate changeChapter. 3. The intervention of multi-omics approaches for developing abiotic stress resistance in cotton crops under climate changeChapter. 4. Big data revolution and machine learning to solve genetic mysteries in crop breedingChapter. 5. Applications of multi-omics approaches for food and nutritional securityChapter. 6. Applications of high throughput phenotypic phenomicsChapter. 7. Basil (Ocimum basilicum L.) : Botany, Genetic resource, Cultivation, Conservation, and Stress factorsChapter. 8. Multi-Omics Approaches for Breeding in Medicinal PlantsChapter. 9. Applications of some nanoparticles and responses of medicinal and aromatic plants under stress conditionsChapter. 10. Sustainable agriculture through technological innovationsChapter. 11. Sustainable Rice Production under Biotic and Abiotic Stress ChallengesChapter. 12. Emerging Techniques to Develop Biotic Stress Resistance in Fruits and VegetablesChapter. 13. Genome editing in crops to control insect pestsChapter. 14. CRISPR revolution in gene editing, targeting plant stress tolerance and physiologyChapter. 15. Genomics for Abiotic Stress Resistance in LegumesChapter. 16. Genetic and molecular factors modulating phosphorous use efficiency in plantsChapter. 17. Recent Trends in Genome Editing Technologies for Agricultural Crops ImprovementChapter. 18. Recent trends and applications of omics based knowledge to end global food hungerChapter. 19. Nutritional enhancement in horticultural crops by CRISPR/ Cas9: status and future prospectsChapter. 20. Physiological interventions of antioxidants in crop plants under multiple abiotic stressesChapter. 21. Proteomics and its scope to study salt stress tolerance in quinoaChapter. 22. Sustainable Cotton Production in Punjab: Failure and its Mitigating StrategiesChapter. 23. Biosafety and biosecurity in genetically modified crops

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Book SynopsisThis book is reflecting upon core theories in evolutionary biology – in a historical as well as contemporary context. It exposes the main areas of interest for discussion, but more importantly draws together hypotheses and future research directions. The Modern Synthesis (MS), sometimes referred to as Standard Evolutionary Theory (SET), in evolutionary biology has been well documented and discussed, but was also critically scrutinized over the last decade. Researchers from diverse disciplinary backgrounds have claimed that there is a need for an extension to that theory, and have called for an Extended Evolutionary Synthesis (EES). The book starts with an introductory chapter that summarizes the main points of the EES claim and indicates where those points receive treatment later in the book. This introduction to the subjects can either serve as an initiation for readers new to the debate, or as a guide for those looking to pursue particular lines of enquiry. The following chapters are organized around historical perspectives, theoretical and philosophical approaches and the use of specific biological models to inspect core ideas. Both empirical and theoretical contributions have been included. The majority of chapters are addressing various aspects of the EES position, and reflecting upon the MS. Some of the chapters take historical perspectives, analyzing various details of the MS and EES claims. Others offer theoretical and philosophical analyses of the debate, or take contemporary findings in biology and discuss those findings and their possible theoretical interpretations. All of the chapters draw upon actual biology to make their points. This book is written by practicing biologists and behavioral biologists, historians and philosophers - many of them working in interdisciplinary fields. It is a valuable resource for historians and philosophers of biology as well as for biologists. Chapters 8, 20, 22 and 33 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsSee attachments

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Book SynopsisThis open access book covers a century of research on wheat genetics and evolution, starting with the discovery in 1918 of the accurate number of chromosomes in wheat. We re-evaluate classical studies that are pillars of the current knowledge considering recent genomic data in the wheat group comprising 31 species from the genera Amblyopyrum, Aegilops, Triticum, and other more distant relatives. For these species, we describe morphology, ecogeographical distribution, phylogeny as well as cytogenetic and genomic features. For crops, we also address evolution under human selection, namely pre-domestication cultivation and domestication. We re-examine the genetic and archeological evidence of where, when, and how domestication occurred. We discuss unique aspects of genome evolution and maintenance under polyploidization, in natural and synthetic allopolyploids of the wheat group. Finally, we propose some thoughts on the future prospects of wheat improvement. As such, it can be of great interest to wheat researchers and breeders as well as to plant scientists and students interested in plant genetics, evolution, domestication, and polyploidy.Table of Contents

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Book SynopsisThe evolution of genome’s modification by genetic engineering was characterized by a major technological breakthrough with the discovery of CRISPR in 2012. A distinction is now made between first-generation biotechnologies developed in the 20th century and current second-generation biotechnologies, NGT or New Genomic Techniques, including genome editing. How do we consider these genomic modifications compared to those that occur spontaneously in nature? What are the applications of these techniques in the fields of plants, animals, and human health? What prospects in terms of development and independence for countries and at least what regulations are in force on the different continents?The book questions what GMOs are, genome editing products and the place of genomic transformations today and tomorrow in our societies. It tries to give some geostrategic and regulatory benchmarks on biotech products in order to better understand the current issues.Table of ContentsPreface Jean-Yves Le Déaut.- Introduction.- First part - Biotechnologies: landmarks and regulatory issues.- Chapter 1 - Biotechnologies: timeless, essential, and ubiquitous.- A broad definition.- Extensive fields of application.- The rise of biotechnology through genetic engineering.- Chapter 2 - Genomic modification, the very essence of biological life.- Incessant modifications of the genome in nature.- Mutagenesis and transgenesis, spontaneous phenomena.- Gene transfer between species.- Genomic selection in agriculture: a very ancient practice.- Conclusion.- Chapter 3 - Evolution of Genome Editing Techniques.- First-generation biotechnology.- Second-generation biotechnology.- Conclusion.- Chapter 4 - At the heart of a societal controversy.- When “crazy soy” meets Greenpeace (1996).- Tribulations of GMO maize crops in France (2007-2014).- A long list of European renunciations.- “Hidden GMOs”.- Conclusion.- Chapter 5 - GMOs: a regulatory concept.- Asilomar.- GMOs: a regulatory concept that differs depending on the country.- Disagreement between regulatory concept and scientific definition.- Conclusion.- Chapter 6 - Is the European regulation on GMOs still justified?.- Regulation, innovation, and the precautionary principle.- European regulations on GMOs.- Onerous and discouraging UE regulation.- UE regulation still relevant?.- Conclusion.- Chapter 7 - What regulation for NGT in the EU?.- The judgment of the EUCJ: context and consequences.- Opening a public debate in the EU.- Conclusion.- Chapter 8 - What regulations for NGT elsewhere in the world?.- American continent.- Asian Continent and Pacific Zone.- Other continents.- Conclusion.- Part two - GMOs in the world.- Chapter 9 - GMOs: medical and animal applications.- Laboratory animals to better understand and fight diseases.- Therapeutic advances.- Improving human nutrition.- Animal applications.- Conclusion.- Chapter 10 - Plant GMOs: agricultural applications.- First transgenic plants.- Characteristics of cultivated transgenic plants.- What are the cultivated transgenic plants?.- What need do these biotech crops meet?.- Respecting good agricultural practices to prevent foreseeable risks.- Is the coexistence of biotech and organic agriculture possible?.- Chapter 11 - Cultivated GMOs: what geopolitical perspective in 2023?.- First-generation agricultural GMOs: a rapid expansion.- What cultures develop?.- A Divided World.- A technology adopted by developing countries and poor farmers.- Commercialization today under the aegis of international consortia.- What to remember from 25 years of GMO crops?.- Conclusion.- Third part - New genomic techniques (NGT)What prospects? What issues?.- Chapter 12 - NGT: at the R&D stage.- Numerous R&D projects.- Patents mainly in the United States and China.- Chapter 13 - Second-generation medical biotechnologies: great hopes.- Therapeutic hopes.- Ongoing developments in medical research.- Two countries dominate.- Globalized, partnership-based medical research.- Conclusion.- Chapter 14 - NGT and animal applications.- Laboratory models.- Veterinary Medicine.- Animal wellbeing.- Livestock performance for food production.- And Europe?.- Conclusion.- Chapter 15 - Second-generation agricultural plant biotechnologies: state of the art.- Dynamism of research in plant breeding.- Global research.- Location by continent.- NGT agricultural plants in perspective.- Appendix: micro-organisms.- Conclusion.- General conclusion - The European Union at the crossroads of biotechnological paths.- Biotechnological innovation, an issue for agri-food and pharmaceutical sovereignty.- At the heart of scientific and academic reflection.- Worldwide recognition

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Book SynopsisSection I An Introduction to Biofilms and Omics.- Introduction to Microbial biofilms.- Microbial Biofilms and Resistome: Concept and Applications.- Fundamentals and Application of Omics in Microbiology.- Microbiomes and biofilms: Fundamentals and Translational Applications.- Section II Omics in Biofilm Research.- Genomic insights in Biofilm research.- Proteomics and their Applications in Biofilm Research.-  Transcriptomics in understanding the Biofilm Dynamics and inhibition.- Metabolomics approaches in understanding the biofilm and its inhibitors.- Metagenomics in understanding the microbial biofilms and Therapeutic Intervention.- Phenomics and microbial biofilms.- Comparative genomics in understanding microbial biofilms.- Lipidomics in understanding microbial biofilms.- Culturomics and biofilms.- Section III Omics as Diagnostic and Therapeutic tools.- Omics in the diagnosis/identification of biofilms.- Omics in Diagnosis and Therapeutics of Polymicrobial biofilms.- Systems biology/Computational systems biology and biofilm.- Synthetic biology and Biofilms.- Omics-based Therapeutics against Biofilm Mechanics.

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Book SynopsisChapter 1. Role of Nuclear Lamins in the Regulation of the Genome: Focus on Cardiolaminopathy.- Chapter 2. Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei.- Chapter 3. Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.- Chapter 4. Laminopathies and Cancers- Involvement of Lamins and Lamin-Chromatin Interactions.- Chapter 5. Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis- tous pour un et un pour tous.- Chapter 6. Changes in Chromatin Organization and  Mechanotransduction Mediated by Mutant Lamins in Laminopathies.- Chapter 7. ECM-Lamin Crosstalk in the Regulation of Genomic Stability.- Chapter 8. The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation?.- Chapter 9. The Role of Lamins in Genome Organization: A Modelling Perspective.- Chapter 10. The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies.- Chapter 11. Dynamic Post-Translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology.

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Book Synopsis

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Book SynopsisAuf dieser DVD-ROM finden Sie die Grafiken und Fotos der 5. Auflage, die Sie als jpg-, PDF- oder PowerPoint Dateien für Ihre Vorlesungen nutzen können.Table of ContentsAbbildungen

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Book SynopsisIn kurzer und anschaulicher Weise gibt Thomas Binz einen Überblick über die biologische Sicherheit im Laborbereich. Die wichtigsten Elemente, wie die Zuteilung der Mikroorganismen zu Risikogruppen, die Bewertung der Risiken bei der Erzeugung von genetisch veränderten Mikroorganismen und die Elemente des Laboratoriums, die im Hinblick auf die biologische Sicherheit besonders relevant sind, werden unter Berücksichtigung der europäischen gesetzlichen Grundlagen dargestellt. Aufgrund des hohen Stellenwerts der Risikobewertung wird detailliert auf dieses Verfahren einschließlich anschaulicher Beispiele eingegangen. Das Buch soll nicht nur einen Überblick über die biologische Sicherheit geben, sondern auch zu ihrem Verständnis beitragen.Der AutorDr. Thomas Binz geht einer behördlichen Tätigkeit im Bereich Biologische Sicherheit nach (Bewilligungswesen, Abschätzung biologischer Risiken gentechnisch veränderter Organismen, nationale und internationale Rechtssetzung, Biowaffenkonvention). Er ist in verschiedenen nationalen und internationalen Ausbildungsprogrammen (Schweizerisches Biosafety Curriculum, Europäische Gesellschaft für Biosicherheit) eingebunden und unterrichtet im Rahmen des französischen 'Diplôme universitaire' für Biosicherheit der Universität Lille.Table of ContentsRisikobewertung.- Biosicherheitsstufe und Maßnahmen.- Biosicherung und Transport von infektiösem Material.

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Book SynopsisThis essential should serve as an introduction for a contemporary public discussion on genetic engineering. Genetic engineering affects us all in many areas and we must dare to think more colorful and further. In fact, the complete genetic material of viruses and bacteria can already be chemically produced and "brought to life". With genetic surgery, medicine is at a crossroads: do we want to treat hereditary diseases or "repair" them genetically? And the analysis of thousands of human genetic material reveals information that is related to complex diseases, but also to characteristics such as intelligence. How should we use this knowledge? The question is hardly whether we want genetic engineering, but rather how we use it.This Springer essential is a translation of the original German 1st edition essentials, Gentechnik by Röbbe Wünschiers, published by The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.Table of ContentsHow is the genetic material read and what does the information say?.- Which methods can be used to modify the genetic material and what are the goals?.- Who owns genetic information and what can be marketed and how?.- How does the environment affect the genetic material?.- Do we want a liberalization of genetic engineering as a civic science?

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Book SynopsisDNA ist das Material von Krimis, Archäologie und Vaterschaftsklagen. Spätestens seit Corona-PCR-Tests sind Nucleinsäuren im wahrsten Sinne des Wortes „in aller Munde“. Dieses Springer-essential beschäftigt sich damit, was man auch mit DNA machen kann. Meist sind diese Dinge ungewöhnlich, manchmal high-tech, hoffentlich lehrreich und eventuell sogar amüsant. Vielleicht ist dieser Band ja eine Anregung für Sie, DNA aus einer anderen Perspektive zu sehen.

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Book SynopsisDieses Buch ist ein wichtiges Manifest für das Verständnis der menschlichen Evolution und Variation im 21. Jahrhundert. Es leistet einen bedeutenden Beitrag zur aktuellen Diskussion über die Rasse. Klischees und Mythen über Rassen werden nicht nur von offenkundigen Rassisten zum Ausdruck gebracht. Auch gut meinende Menschen vertreten durch ihren kulturellen Erfahrungshorizont Ansichten, die nicht durch die moderne Humangenetik gestützt werden. Sogar der wissenschaftliche Rassismus greift zunehmend um sich und beeinflusst den öffentlichen Diskurs über Politik, Migration, Bildung, Sport und Intelligenz. Der Leser bekommt Argumente an die Hand, um dem entgegen zu treten. Adam Rutherford zeigt, dass die moderne Humangenetik ein mächtiger Verbündeter gegen Rassismus sein kann. Sie zeigt, wie Menschen tatsächlich sind, und nicht, wie sie von der Gesellschaft gesehen werden.Table of ContentsEine Bemerkung über die Sprache.- Vorwort zur Taschenbuchausgabe.- Einleitung.- Haut im Spiel.- Deine Vorfahren sind meine Vorfahren.- Black Power.- Weiße Substanz.- Zusammenfassung und Schluss.

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Book SynopsisWith CRISPR/Cas gene editing tools in hand, we are currently experiencing a new dimension in genetic engineering. But where should the journey lead? Should we treat diseases or better repair them genetically? Will the new genetic engineering, combined with modern reproductive biology, lead to designer babies? And: May we allow a liberalization of these techniques as citizen science? New methods can precisely alter the genetic material - and they leave no traces. This gene and genome surgery thrives on increasing knowledge about the mode of action of genes, those trait-giving regions in the genome. This knowledge is being applied in practice, particularly in the breeding of more resistant and higher-yielding crops. And what about us? The author shows that gene variants have long been associated not only with diseases, but also with nutritional preferences or intelligence. Therapeutic and optimization options are close at hand. What effect does the environment have on the expression of genetic material? Genes can be shaped during a person's lifetime by the environment, nutrition or experiences and thus passed on to their offspring in a modified form. So, does society have a new form of long-term responsibility for (epi)genetic integrity? In this vividly and comprehensibly written book, the author explains the state of genetic engineering without assuming too much prior knowledge and invites an open dialogue on this ambivalent topic. Get your own idea of the fascinating yet intimidating possibilities of genetic engineering. Where do you stand on the issue? With the help of this book, you have the chance to form a differentiated opinion. This book is a translation of the original German 1st edition Generation Gen-Schere by Röbbe Wünschiers, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text was subsequently revised by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Table of ContentsPreliminary thoughts.- What is genetic information? .- Breeding yesterday until today.- Read genetic material.- Edit genetic material.- Write genetic material.- Genes and society.- Rethink genetics, - And now ?.

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Book SynopsisThis book is written in a very simple and lucid manner so that everybody can read and understand it very easily. This book is useful for scientists, teachers, students, officers, diagnosticians and laboratory technicians as cell culture has become an essential and indispensable tool in many branches of life sciences and application of cell culture is getting increased exponentially day by day in various fields of biological and medical research arena. This book will provide detailed information on all the aspects of the cell culture starting from establishment of a cell culture laboratory, primary culture, secondary culture, media filtration, collection, preservation and dispatch of samples for diagnosis of viral diseases, cell line authentication and characterization, contamination and curing, cryopreservation of cells and revival of cells besides description on ELISA, SNT, virus titration etc. In my opinion, this book will be extremely useful to the persons who are directly and indirectly involved in cell culture work for various biological experiments. Finally, students and examinees can enrich their knowledge on cell culture from the book and can face any challenge easily and confidently. s on the latest developments on biotechnological approaches for fish disease diagnostic, infection and immunity of brood carps, cryoconservation of fishes, probiotics and nanotechnology in aquaculture are of paramount interest, in addition to information on prawn aquaculture, ornamental fish farming and trade. Information on various software and their application for exploratory data analysis and data mining leading to knowledge discovery and visualization is the main attraction of the book. Another important feature of the book is that one can find appropriate as well as illustrated examples exclusively with fisheries data. The statistics section includes biometrical and qualitative techniques in genetics and selective breeding of fish, besides fundamental statistical test, design of experiments and sampling methods for planning of experiments and survey in fisheries and aquaculture research. The book also includes econometric approach for technical efficiency estimation and input-output analysis, project evaluation, and impact assessment, linear programming, market intelligence, fisheries legislation, policy and IPR issues all of which are new in the field of fisheries and aquaculture.

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Book SynopsisThe book Plant Breeding and Genetics provides an overview of the fundamental principles of plant breeding and genetics, and is designed to serve as a textbook for undergraduate students. The books chapters cover a wide range of topics, including statistical and biotechnological applications, making it a useful resource for students studying undergraduate genetics and/or plant breeding. Each chapter begins with a clear definition of key terms and concepts, followed by an in-depth exploration of the chapters core issues. The book includes a variety of illustrations and solved numerical problems to aid in understanding, and concludes with a comprehensive glossary that includes modern developments. This book will be particularly useful for undergraduate students, but can also be beneficial for postgraduate students seeking a deeper understanding of the fundamentals of plant breeding and genetics.

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Book SynopsisThis book is intended to provide a comprehensive understanding of the fundamental concepts and practical applications of Cytology and Genetics. It encompasses all aspects of the subject, including information on the microscope, cell division, Mendelian principles of heredity, linkage and detection, gene mapping through recombination, multiple alleles, and gene interaction and probability. The practical information outlined in this guide will be of great benefit to students and educators in the fields of Biological and Agricultural Sciences.

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Book SynopsisAbiotic stresses have become a significant aspect of crop production, with their presence either in the soil, water, or atmosphere. The book aims to present the information regarding injury and tolerant mechanisms, variability for tolerance, breeding, and biotechnology for the improvement of crop plants against abiotic stresses in an organized manner, with up-to-date citations and a comprehensive literature of recent advances. The book emphasizes the elaboration of injury and tolerance mechanisms, as well as the development of improved genotypes against stress environments. The book also covers the plants symptoms of specific abiotic stress, reclamation of soil and crop/cropping patterns to overcome the effects of adverse conditions. Each topic is addressed with systematic approaches to develop abiotic stress-tolerant genotypes using biotechnological tools. The use of molecular markers in stress tolerance and the development of transgenic plants have also been detailed. Moreover, the book discusses the effects of air pollution and climate change on crop plants. It details the oxidative stress caused by abiotic stress, where plants produce a large quantity of free radicals (oxidants). The book is divided into seven major parts: physical stress (salt), water stresses (drought and waterlogging), temperature stresses (heat and cold), metal toxicities (aluminum, iron, cadmium, lead, nickel, chromium, copper, zinc, etc.), and non-metal toxicities (boron and arsenic), oxidative stress, and finally atmospheric stresses (air pollution, radiation, and climate change). This book will be beneficial for students and researchers, particularly Plant Breeders and Biotechnologists, as well as Botanists, to understand the injury and tolerance mechanisms and subsequently improve crop genotypes for abiotic stresses.

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