Diseases and disorders Books

Book SynopsisTable of ContentsSection 1: Immunologic Basis of Autoimmunity 1. Prelude: Historical introduction to autoimmunity and autoimmune disease 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 3. General Features of Autoimmune Diseases 4. Antigen Presentation, Dendritic Cells, and Autoimmunity 5. T cells and their subsets 6. Role of Th1 Th2 Th17 Cells in Autoimmunity 7. Tolerance and Autoimmunity: T Cells 8. Regulatory T Cells 9. B Cells and Autoimmunity 10. Immunological memory T cells 11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens 13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 14. Functional Effects of Autoantibodies 15. Cytokine Chemokines 16. Signaling Pathways in T and B Lymphocytes 17. HLA Genetics and Autoimmunity 18. Non HLA Genetics 19. AIRE related Autoimmunity 20. Immune Deficiencies and Autoimmunity 21. Infections and Autoimmunity 22. Noninfectious Environmental Agents and Autoimmunity 23. Sex, Pregnancy and Autoimmunity 24. Animal Models of Autoimmune Disease Section 2: Multisystem Diseases 25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma 27. Antiphospholipid Syndrome 28. Sjogren Syndrome 29. Rheumatoid Arthritis 30. Spondyloarthritis and Chronic Idiopathic Arthropathies 31. Myositis 32. Thyroid Disease 33. Type 1 Diabetes 34. Adrenalitis 35. Polyendocrine Syndromes 36. Gastritis and Pernicious Anemia 37. Hypophysitis 38. Hemolytic Anemia 39. Thrombocytopenic Purpura 40. Neutropenia 41. Aplastic Anemia 42. Clotting Disorders 43. Multiple Sclerosis 44. Peripheral Neuropathy 45. Myasthenia Gravis 46. Ocular Disease 47. Inner Ear Disease 48. Celiac Disease 49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease 50. Chronic Hepatitis 51. Primary Billiary Cirrhosis 52. Primary Sclerosing Cholangitis 53. Pancreatitis 54. Bullous Skin Diseases: Pemphigus and Pemphigoid 55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria 56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 57. Orchitis and Male Infertility 58. Oophoritis 59. Rheumatic Heart Disease 60. Myocarditis and Dilated Cardiomyopathy 61. Necrotizing Arteritis and Small Vessel Vasculitis 62. Large and Medium Vessel Vasculitides 63. Autoimmune Disorders of the Lung 64. Paraneoplastic Diseases 65. Antibody-Associated Neurological Diseases 66. Autoinflammatory and other Related Diseases Section 3: Diagnosis, Prevention, and Therapy 67. Autoantibody Assays, Testing, and Standardization 68. Prediction of Autoimmune Disease 69. Emerging Therapies for Autoimmune Diseases 70. Postlude

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Book SynopsisAbout our authors Mark F. Sanders has been a faculty member in the Department of Molecular and Cellular Biology at the University of California, Davis, since 1985. In that time, he has taught more than 150 genetics courses to nearly 35,000 undergraduate students. Although he specializes in teaching the genetics course for which this book is written, his genetics teaching experience also includes a genetics laboratory course, an advanced human genetics course for biology majors, and a human heredity course for nonscience majors, as well as introductory biology and courses in population genetics and evolution. He has also served as an advisor to undergraduate students and in undergraduate education administration, and he has directed several undergraduate education programs. Dr. Sanders received his B.A. degree in Anthropology from San Francisco State University, his M.A. and Ph.D. degrees in Biological Anthropology from the University of California, LTable of Contents1. The Molecular Basis of Heredity, Variation, and Evolution 2. Transmission Genetics 3. Cell Division and Chromosome Heredity 4. Inheritance Patterns of Single Genes and Gene Interaction 5. Genetic Linkage and Mapping in Eukaryotes 6. Genetic Analysis and Mapping in Bacteria and Bacteriophage Application Chapter: Part I: Genetic Counseling 7. DNA Structure and Replication 8. Molecular Biology of Transcription and RNA Processing 9. The Molecular Biology of Translation Application Chapter: Part II: Genetic Testing 10. Chromosome Chapter Title TBD 11. Gene Mutation, DNA Repair, and Homologous Recombination 12. Chromosome Chapter Title TBD 13. Regulation of Gene Expression in Bacteria and Bacteriophage 14. Regulation of Gene Expression in Eukaryotes 15. Analysis of Gene Function by Forward Genetics and Reverse Genetics Application Chapter: Part III: Cancer Genetics 16. Recombinant DNA Technology and Its Applications 17. Genomics: Genetics from a Whole-Genome Perspective 18. Organelle Inheritance and the Evolution of Organelle Genomes 19. Developmental Genetics 20. Genetic Analysis of Quantitative Traits Application Chapter: IV: Personalized Medicine 21. Population Genetics and Evolution at the Population, Species, and Molecular Levels Application Chapter: V: Forensic Genetics

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Book SynopsisTable of Contents A Brief History of Microbiology The Chemistry of Microbiology Cell Structure and Function Microscopy, Staining, and Classification Microbial Metabolism Microbial Nutrition and Growth Microbial Genetics Recombinant DNA Technology Controlling Microbial Growth in the Environment Controlling Microbial Growth in the Body: Antimicrobial Drugs Characterizing and Classifying Prokaryotes Characterizing and Classifying Eukaryotes Characterizing and Classifying Viruses, Viroids, and Prions Infection, Infectious Diseases, and Epidemiology Innate Immunity Specific Defense: Adaptive Immunity Immunization and Immune Testing Hypersensitivities, Autoimmune Diseases, and Immune Deficiencies Pathogenic Gram-Positive Bacteria Pathogenic Gram-Negative Cocci and Bacilli Rickettsias, Chlamydias, Spirochetes, and Vibrios Pathogenic Fungi Parasitic Protozoa, Helminths, and Arthropod Vectors Pathogenic DNA Viruses Pathogenic RNA Viruses Applied and Industrial Microbiology Microbial Ecology and Microbiomes

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Book SynopsisOsteoporosis currently affects 25 million people in the United States, and as the baby boomers enter their fifties, the disease is poised to strike millions more. In this text, readers will find everything they need to know to slow, stop, and even reverse the bone loss that causes osteoporosis.Trade Review"This comprehensive book was written as a guide for patients and their families and, as such, covers a variety of topics related to osteoporosis in a simple, well-explained way....This is an excellent reference."--Physiotherapy Canada"Although much more widespread among women, osteoporosis also strikes men, so this overview of the disease speaks to a larger audience than many may suspect. Lane uses her experience as a clinician to add greatly to the book, notably in the case histories she cites and the understanding of patients she expresses."--Booklist"A concise, authoritative overview of this major health problem largely affecting women.... Lane makes effective use of case studies throughout the text to illustrate typical risk situations and treatment options. Recommended for both public and academic libraries for the more sophisticated consumer."--Library Journal"The Osteoporosis Book by osteoporosis researcher Nancy E. Lane, M.D., codirector of rheumatology at San Francisco General Hospital, covers all bases: a description of the disease and its causes, who is at risk, diagnosis, prevention, treatment and dealing with its pain and problems."--Consumers Digest

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Book SynopsisThe treatment outlined in this therapist guide is intended for people suffering from depression and living with chronic illnesses. As a result of their poor health, many individuals who are chronically ill become depressed and fail to maintain steady self-care routines. Using this guide, therapists can help clients with chronic illnesses to develop core skills and tecniques that will enable them to take better care of themselves. The program incorporates a unique Life-Steps module that teaches clients strategies for keeping up with their medical regimens, including tips for remembering to take medications, getting to medical appointments on time, and communicating effectively with medical providers.Based on the principles of CBT, this guide provides therapists with overviews of adherence behaviours for select illnesses including cancer, HIV, diabetes, and hypertension, among others. The chapters detail adherence skills, integrated with cognitive and behavioural strategies for managing Table of Contents1. Introductory Information for Therapists ; 2. Overview of Adherence Behaviors for Selected Illnesses ; 3. Module 1: Psychoeducation about CBT and Motivational Interviewing ; 4. Module 2: Adherence Training (Life Steps) ; 5. Module 3: Activity Scheduling ; 6. Module 4: Cognitive Restructuring (Adaptive Thinking) ; 7. Module 5: Problem-Solving ; 8. Module 6: Relaxation Training and Diaphragmatic Breathing ; 9. Module 7: Review, Maintenance, and Relapse Prevention

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Book SynopsisLupus, a disease of the immune system, can be quite deadly, claiming the lives of thousands of patients yearly. Dr. Daniel J. Wallace is one of the world''s leading authorities on this disorder, an eminent clinician who has treated over 3,000 lupus patients, the largest such practice in America. His The Lupus Book, originally published in 1995, immediately established itself as the most readable and helpful book on the disease.Now Dr. Wallace has once again completely revised The Lupus Book, incorporating a wealth of new information. This book discusses new drug information and newly discovered information about the pathology of the disease all laid out in user-friendly language that any patient could understand. In particular, Wallace discusses the first drug for lupus to be approved by the FDA--belimumab (Benlysta)--as well as other drugs in clinical trials. Readers will also discover sections on the science of lupus and breakthroughs in research including: genetics, microbiome, and clinical trial methodology. And as in past editions, the book provides absolutely lucid answers to such questions as: What causes lupus? How and where is the body affected? Can a woman with lupus have a baby? And how can one manage this disease? Indeed, Dr. Wallace has distilled his extensive experience, providing the most up-to-date information on causes, prevention, cure, exercise, diet, and many other important topics. There is also a glossary of terms and an appendix of lupus resource materials compiled by Dr. Wallace. This new seventh edition discusses new treatments, review of pathogenesis, new laboratory tests

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Book SynopsisThe Fundamentals of Biomedical Science series has been written to reflect the challenges of practising biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a biomedical scientist may be exposed - from microbiology to cytopathology to transfusion science.Biology of Disease provides an integrated introduction to the basic cell biology that underlies disease processes and the diagnosis and management of those diseases. By telling the whole story of how a disease develops, how it is diagnosed, and how it is treated, the text provides a thorough understanding of both the molecular and clinical aspects of diseases that are needed to succeed as a practising health care professional. Featuring a wide range of diseases, the

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Book SynopsisPsychosomatic Medicine (PM) is a rapidly developing subspecialty of psychiatry focusing on psychiatric care of patients with other medical disorders. PM specialists diagnose and manage psychiatric symptoms in a variety of medical settings, optimize their patients'' medical care, and expand understanding regarding the role of psychological factors in health and disease.Dr. Kurt Ackerman and Dr. Andrea DiMartini presernt Psychosomatic Medicine , portable handbook geared to helping psychiatric and other medical practitioners and trainees to stay current in their understanding of the practice of psychosomatic medicine. Drawing practical techniques and wisdom from their team of contributors, Psychosomatic Medicine provides readers with historical background, key clinical information and guidelines, readily accessible charts and tables, exercises to aid in self-assestment, and suggestions for further reading to spark additional learning in this rapidly developing field of psychiatry.Trade ReviewIncreasing recognition of the effects of comorbid psychiatric disorders that accompany medical conditions mandates that all physicians including psychiatrists, understand that recognition and management of such coexisting clinical entities is imperative. This convenient volume encompasses such information in a practical yet comprehensive manner. From common symptoms such as anxiety, depression, insomnia and agitation to specific disease entities where psychiatric disorders commonly coexist, the book offers the clinician a guide to effective and evidence based management. Psychosomatic Medicine should be on the desk or in the pocket of all clinicians, whether a seasoned practitioner or a resident. * Thomas N. Wise, MD, Professor of Psychiatry, Johns Hopkins University School of Medicine. *This is a small and portable handbook packed with the latest information on commonly encountered psychosomatic medicine topics. It summarizes current scientific literature and condenses it down to need-to-know basics. Its standardized format, easy-to-reference tables, and eloquent conciseness make it incredibly easy to use. Clinicians and trainees in psychiatric and medical practice will find this a valuable tool. * - Heather Huang, MD, University of Wisconsin School of Medicine and Public Health. *Table of ContentsIntroduction ; 1. History of Psychosomatic Medicine and Consultation-Liaison Psychiatry ; 2. Psychiatric Consultation in the Inpatient General Medical Setting ; Psychiatric Diagnosis and Management in the General Medical Setting ; 3. Mood Disorders and Insomnia in the General Medical Setting ; 4. Anxiety in the General Medical Setting ; 5. Somatic Symptom and Related Disorders ; 6. Psychopharmacology in the General Medical Setting ; 7. Management of Agitation in the General Medical Setting ; 8. Strategies to Improve Coping and Manage Maladaptive Behaviors in the General Medical Setting ; 9. Assessment of Decision-Making Capacity ; Psychiatric Presentations Associated with Neurologic and Other Medical Conditions ; 10. Delirium ; 11. Neurocognitive Disorders in the General Medical Setting ; 12. Psychiatric Presentations Associated with Neurologic Illness ; 13. Psychiatric Presentations Associated with Organ Failure and Systemic Illness ; Emergent Complications of Medication and Substance Use ; 14. Catatonia, Neuroleptic Malignant Syndrome, and Serotonin Syndrome ; 15. Toxidromes: Toxicology and the Psychiatric Patient ; 16. Substance Intoxication and Withdrawal States in the General Medical Setting ; Special Topics in Psychosomatic Medicine ; 17. Perinatal Psychiatry ; 18. Psycho-Oncology ; 19. Organ Transplant Psychiatry ; 20. Psychiatric Evaluation and Management of Pain ; 21. Psychiatry in Palliative Care ; 22. Future Directions in Psychosomatic Medicine

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Book SynopsisSurgical Pain Management is an essential, step-by-step guide to surgical techniques and the perioperative management of chronic pain patients whose treatment includes implantable therapies. Chapters review the steps necessary for defining a potential candidate for implant and the infrastructure to support the perioperative period and beyond, controversies in approaches for both intrathecal and spinal cord stimulation implants, healthcare education for patients with these devices, neuroaxial drug delivery, electrical stimulation of the peripheral and central nervous system, and a variety of invasive procedures for chronic and cancer pain. Appendices provide supplemental information regarding guidelines, physiology, technologies available, troubleshooting, and documentation required to organize an interventional service. This book details a range of approaches from basic implant therapies to more advanced therapies, making it an ideal companion to an advanced training program in intervenTrade ReviewThe inclusion of case studies and the multiple forms for provision of care, not seen in other texts, serves to elevate its functional value... The conciseness of this text makes it easy to reference. * Collin Clarke, Canadian Journal of Anesthesia *I am confident that this book is an excellent addition in Interventional Pain disciplines. The flow and content in most of the chapters is adequate and focused towards the title of the chapter...this is a well written and informative guide for all practicing physicians * Gauhar Afshan, Anaesthesia, Pain & Intensive Care *It provides comprehensive knowledge and the collective experience and insight of over forty healthcare professionals involved in pain alleviation. * Nano Khilnani, Biz India Online News *It will be of help for pain specialists and for those who are considering training in pain as a subspecialty. The book allows comparison of your practice with theway in which it is performed in a leading academic department. * P. L. Gambus, British Journal of Anaesthesia *Any physician or health professional working in the field of chronic pain should have this book in their collection to better understand how implantable devices for the management of pain work and what the clinician and patient should know about them. * Open Pain Journal Vol. 9, Serge Marchand, Ph.D. *Table of ContentsPart I: Foundations of a Surgical Pain Management Team 1. Organization of an Implant Service 2. Anesthetic Management for Chronic Pain Surgery 3. Psychological Evaluation of the Surgical Pain Patient 4. Patient Education for Surgical Intervention for Pain Part II: Operations in Surgical Pain Management 5. Implantable Drug Delivery Systems 6. Externalized Epidural Infusion Systems 7. Dorsal Column Stimulation 8. Peripheral Nerve Stimulation 9. Craniofacial Nerve Stimulation 10. Field Stimulation 11. Sacral Nerve Stimulation 12. Treatment of Discogenic Pain: Minimally Invasive Procedures 13. Vertebroplasty and Kyphoplasty 14. Minimally Invasive Treatments for Spinal Stenosis: Percutaneous Lumbar 15. Endovenous Ablation Part III. Appendices Appendix 1. ASRA Anticoagulation Guidelines Appendix 2. Applied Spinal Anatomy Appendix 3. Pharmacology of Intrathecal Medications Appendix 4. CSF Pharmacokinetics Appendix 5. Guide to Choosing Electrodes and Pulse Generators Appendix 6. Problem Solving Stimulator Malfunction Appendix 7. Implantable Devices and Equipment Appendix 8. FDA Medical Device Reporting Appendix 9. Sample OR Dictations Appendix 10. Surgeon's Preference Cards Appendix 11. Preventing Surgical Site Infections: Antimicrobial Prophylaxis, Skin Preparation and Surgical Field Draping Appendix 12. Incisions, Wounds and Suturing Appendix 13. Surgical Instruments

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Book SynopsisThis handbook describes the diagnostic process clearly and logically, aiding medical students and others who wish to improve their diagnostic performance and to learn more about the diagnostic process.Trade ReviewThis is a nice memory aid for new clinicians as well as a refresher for clinicians who have been in the practice of medicine for a long time. * Doody's Notes *This book is useful for medical students of all years... and is perfect for ILAs, finals revision and wards round. As with all Oxford Handbooks, its handy size makes it very placement friendly. * North Wing *Table of Contents1. The diagnostic process ; 2. Interpreting the history and examination ; 3. General and endocrine symptoms and physical signs ; 4. Skin symptoms and physical signs ; 5. Cardiovascular symptoms and physical signs ; 6. Respiratory symptoms and physical signs ; 7. Gastrointestinal symptoms and physical signs ; 8. Urological and gynaecological symptoms and physical signs ; 9. Joint, limb, and back symptoms and physical signs ; 10. Psychiatric and neurological symptoms and physical signs ; 11. Laboratory tests ; 12. Chest x-rays ; 13. Making the diagnostic process evidence-based

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Book SynopsisCOVID-19: A History presents a global history of the virus, with a focus on Canada. Jacalyn Duffin’s broad approach ranges from medical interventions, such as the development of tests, treatments, and vaccines, to the practical politics behind quarantines, barrier technologies, lockdowns, and social and financial supports.Trade Review“As a physician, historian, and now volunteer contact-tracer, Duffin provides a unique perspective on the history of COVID-19. This well-written and engaging book is the most detailed historical overview to date on the first waves of the pandemic in Canada and around the world.” Catherine Carstairs, University of Guelph and author of The Smile Gap: A History of Oral Health and Social Inequality“Although there is a COVID book on almost every topic, Jacalyn’s Duffin’s history instantly stands out. She has written a global history that is both measured and sophisticated. Although there will be other histories of the pandemic, I am confident that Duffin’s analysis will occupy an important place in the historiography of COVID-19 for years to come.” The American Review of Canada Studies“With verve and skill, Duffin tells a compelling story that is familiar in its big picture and new in its fine details. In the hands of most any other scholar, a short history of COVID-19 would be a blur, but in the hands of this leading medical historian, it’s a tour-de-force of smart analysis and clear writing. Among Duffin’s many strengths are her ability to draw on ancient, medieval, early modern, and modern history to deepen our understanding of the present, as well as her ability to weave different themes in and out of her text. Two stand out: scapegoating and the social determinants of health.” Literary Review of Canada

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Book SynopsisTrade ReviewAn excellent introduction to the origins introduction to the origins of schizophrenia, which brings together a large amount of recent work in a readable and critical manner. -- Michael Owen The British Journal of PsychiatryTable of ContentsForeword, by Robert Freedman Acknowledgments Introduction, by Alan S. Brown and Paul H. Patterson Overview: Schizophrenia and the Lifetime Trajectory of Psychotic Illness: Developmental Neuroscience and Pathobiology, Redux, by John L. Waddington, Robin J. Hennessy, Colm M. P. O'Tuathaigh, Olabisi Owoeye, and Vincent Russell Part 1. Clinical Research on Risk Factors for Schizophrenia Section 1. Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia 1. Maternal Infection and Schizophrenia, by Alan S. Brown 2. Prenatal Nutrition and the Etiology of Schizophrenia, by Kristin N. Harper and Alan S. Brown 3. Obstetric Complications and Schizophrenia: Historical Overview and New Directions, by Mary Clarke, Sarah Roddy, and Mary Cannon 4. Maternal Stress During Pregnancy and Schizophrenia, by Mary C. Iampietro and Lauren M. Ellman 5. Advancing Paternal Age and the Risk for Schizophrenia, by Sarah Crystal, Karine Kleinhaus, Mary Perrin, and Dolores Malaspina 6. Cannabis Use as a Component Cause of Schizophrenia, by Paola Casadio, Marta Di Forti, and Robin M. Murray Section 2. Genetics and Epigenetics 7. Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies?, by Alan R. Sanders, Jubao Duan, and Pablo V. Gejman 8. Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation, by Maria Karayiorgou, Rebecca J. Levy, and Bin Xu 9. The Epigenetics of Schizophrenia, by Iris Cheung, Mira Jakovcevski, and Schahram Akbarian Part 2. Preclinical Research on Etiologies of Schizophrenia Section 1. Animal Models of Environmental Factors and Schizophrenia 10. Animal Models of the Maternal Infection Risk Factor for Schizophrenia, by Paul H. Patterson 11. Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia, by Xiaoying Cui, Darryl W. Eyles, Thomas H. J. Burne, and John J. McGrath 12. Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia, by Lisa M. Tarantino, Teresa M. Reyes, and Abraham A. Palmer 13. Animal Models of the Maternal Stress Risk Factor for Schizophrenia, by Paul H. Patterson Section 2. Animal Models of Genetic Factors and Schizophrenia 14. DISC1: A New Paradigm for Schizophrenia and Biological Psychiatry, by David Porteous 15. Mutant Models of Nrg1 and ErbB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia, by Yachi Chen, Lorna W. Role, and David A. Talmage List of Contributors Index

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Book SynopsisRosemary Walker worked for many years as a diabetes specialist nurse and has been at the forefront of national initiatives to improve diabetes care. Her philosophy is to acknowledge people's ability to make their own decisions about what is right for them. In 2002, she founded In Balance Healthcare UK with fellow diabetes nurse, Jill Rodgers, to provide training for people with diabetes and for health professionals, to make diabetes services more effective. Rosemary's present company, Successful Diabetes, provides information, workshops, and resources for living and working with diabetes. She is an established writer of books, articles, and comment about diabetes, including the book Diabetes: A practical guide to managing your health (DK 2004) with Jill Rodgers.

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Book SynopsisFirst book-length treatment of model-based meta-analytic methods for descriptive epidemiologyTable of ContentsFigures Tables Acknowledgments Introduction | by Abraham D. Flaxman, Theo Vos, and Christopher J.L. Murray 1. An Introductory Example 2. A Motivating Example 3. From Systematic Review to Metaregression 4. History of Generic Disease Modeling 5. What is Not in This Book Section One | Theory and Methods 1. Background material on Bayesian methods / Abraham D. Flaxman 1.1 A meta-analysis example 1.2 Another meta-analysis example 1.3 Summary 2. Statistical models for rates, ratios, and durations / Abraham D. Flaxman 2.1 A motivating example 2.2 Binomial model 2.3 Beta-binomial model 2.4 Poisson model 2.5 Negative-binomial mode 2.6 Transformed normal models 2.7 Lower-bound data model 2.8 Quantification of uncertainty 2.9 Comparison 2.10 Summary and future work 3. Age pattern models / Abraham D. Flaxman 3.1 Definition of spline models 3.2 Choosing knots 3.3 Penalized spline models 3.4 Augmenting the spline model 3.5 Summary and future work 4. Expert priors on age patterns / Abraham D. Flaxman 4.1 Priors on level 4.2 Priors on monotonicity 4.3 Priors are not just for splines 4.4 Hierarchical similarity priors on age patterns 4.5 Summary and future work 5. Statistical models for heterogeneous age groups / Abraham D. Flaxman 5.1 Overlapping age-group data 5.2 Midpoint model 5.3 Disaggregation model 5.4 Midpoint model with group width covariate 5.5 Age-standardizing and age-integrating models 5.6 Model comparison 5.7 Summary and future work 6. Covariate modeling / Abraham D. Flaxman 6.1 Cross-walk fixed effects to explain bias 6.2 Predictive fixed effects to improve out-of-sample estimation 6.3 Fixed effects to explain variance 6.4 Random effects for spatial variation 6.5 Covariates and consistency 6.6 Summary and future work 7. Prevalence estimates from other data types / Abraham D. Flaxman 7.1 A motivating example 7.2 System dynamics model of disease in a population 7.3 Endemic equilibrium 7.4 Forward simulation examples 7.5 Summary and future work 8. Numerical algorithms / Abraham D. Flaxman 8.1 Markov chain Monte Carlo 8.2 The Metropolis-Hastings step method 8.3 The Adaptive Metropolis step method 8.4 Convergence of the MCMC algorithm 8.5 Initial values for MCMC 8.6 A meta-analysis example 8.7 Empirical Bayesian priors to borrow strength between regions 8.8 Summary and future work 8.9 Challenges and limitations Section Two | Applications 9. Knot selection in spline models / Yong Yi Lee, Theo Vos, Abraham D. Flaxman, Jed Blore, and Louisa Degenhardt 10. Unclear age pattern, requiring expert priors / Hannah M. Peterson, Yong Yi Lee, Theo Vos, and Abraham D. Flaxman 11. Empirical priors / David Chou, Hannah M. Peterson, Abraham D. Flaxman, Christopher J.L. Murray, and Mohsen Naghavi 12. Overlapping, heterogeneous age groups / Mohammad H. Forouzanfar, Abraham D. Flaxman, Hannah M. Peterson, Mohsen Naghavi, and Sumeet Chugh 13. Dealing with geographical variation / Abraham D. Flaxman, Khayriyyah Mohd Hanaah, Justina Groeger, Hannah M. Peterson, and Steven T. Wiersma 14. Cross-walking with fixed effects / Amanda Baxter, Jed Blore, Abraham D. Flaxman, Theo Vos, and Harvey Whiteford 15. Improving out-of-sample prediction / Ali Mokdad, Abraham D. Flaxman, Hannah M. Peterson, Christopher J.L. Murray, and Mohsen Naghavi 16. Risk factors / Stephen S. Lim, Hannah M. Peterson, and Abraham D. Flaxman 17. The compartmental model / Sarah K. Wulf, Abraham D. Flaxman, Mohsen Naghavi, and Giuseppe Remuzzi 18. Knot selection in compartmental spline models / Marita Cross, Damian Hoy, Theo Vos, Abraham D. Flaxman, and Lyn March 19. Expert priors in compartmental models / Alize Ferrari, Abraham D. Flaxman, Hannah M. Peterson, Theo Vos, and Harvey Whiteford 20. Cause-specific mortality rates / Theo Vos, Jed Blore, Abraham D. Flaxman, Hannah M. Peterson, and Juergen Rehm Conclusion / Abraham D. Flaxman, Christopher J.L. Murray, and Theo Vos Appendix: GBD Study 2010 spatial hierarchy References Contributors About the editors Index

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Book SynopsisMalaria Control During Mass Population Movements and Natural Disasters provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.Table of Contents1 Front Matter; 2 1. Introduction; 3 2. Malaria and Mobility -- A Brief History and Overview; 4 3. Epidemiology of Malaria; 5 4. Essential Components/Design of an Optimal Malaria Control Program; 6 5. Public Health Surveillance System; 7 6. Curative Services: Malaria Therapy and Case Management; 8 7. Preventive Interventions; 9 8. Community Involvement in Malaria Control and Prevention; 10 9. Special Studies and Operational Research; 11 10. Prophylaxis and Personal Protection for Relief Workers; 12 11. Return, Repatriation, or Resettlement of Displaced Populations; 13 12. Improving Malaria Control in Complex Emergencies; 14 References; 15 Appendix A: Description of Antimalarial Drugs; 16 Appendix B: Methodology for Efficacy Assessment of In Vivo Malaria Therapy; 17 Appendix C: Alternative Treatment Regimens for Severe Malaria; 18 Appendix D: Malaria Research and Technical Resources; 19 Appendix E: About the Authors

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Book SynopsisIn 2003 Congress passed the United States Leadership Against HIV/AIDS, Tuberculosis, and Malaria Act, which established a 5-year, $15 billion initiative to help countries around the world respond to their AIDS epidemics. This book recommends that the program should focuses on the long-term strategic planning and capacity building.

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Book SynopsisTable of ContentsPART I: Wellness, Nutrition, and the Nursing Role 1. Wellness Nutrition 2. Personal and Community Nutrition PART II: Nutrients, Food, and Health 3. Digestion, Absorption, and Metabolism 4. Carbohydrates 5. Fats 6. Protein 7. Vitamins 8. Water and Minerals PART III: Health Promotion Through Nutrition and Nursing Practice 9. Energy, Weight and Fitness 10. Nutrition Across the Life Span PART IV: Overview of Medical Nutrition Therapy 11. Nutrition Assessment and Patient Care 12. Food-Related Issues 13. Nutrition for Disorders of the Gastrointestinal Tract 14. Nutrition for Disorders of the Liver, Gallbladder, and Pancreas 15. Nutrition for Diabetes Mellitus 16. Nutrition in Metabolic Stress: Burns, Trauma, and Surgery 17. Nutrition for Cardiopulmonary Disease 18. Nutrition for Diseases of the Kidneys 19. Nutrition for Neuro-Psychiatric Disorders 20. Nutrition in Cancer and HIV-AIDS Glossary Index

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Book SynopsisMorton Kondracke never intended to wed Millicent Martinez, but the fiery daughter of a radical labor organizer eventually captured his heart. They married, raised two daughters, and loved and fought passionately for twenty years. Then, in 1987, Milly noticed a glitch in her handwriting, a small tremor that would lead to the shattering diagnosis of Parkinson’s disease. Saving Milly is Kondracke’s powerfully moving chronicle of his vital and volatile marriage, one that has endured and deepened in the face of tragedy; it also follows his own transformation from careerist to caregiver and activist, a man who will “fight all the way, without pause or rest, to ‘save’ his beloved Milly.” *(* Linda Bowles, The Washington Times)

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Book SynopsisThe eagerly awaited 2nd edition of this classic handbook is a critical, thorough account of memory disorders relating to neurological processes and to developmental and acquired brain damage and presents comprehensive sections on theory, assessment, treatment and management of memory disorders.Trade Review“…incorporates several changes and additions that reflect the progress that has been made…promises to be a valuable resource…” (The Quarterly Journal of Experimental Psychology, Vol 57A(5), 2004)Table of ContentsAbout the Editors. List of Contributors. Preface. Preface to the First Edition. SECTION I: THEORETICAL BACKGROUND. The Psychology of Memory (A. Baddeley). Neurobiological Foundations of Human Memory (D. Tranel and A.Damasio). Functional Neuroimaging of Memory (M. Rugg). The Medial Temporal Lobe and Memory for Facts and Events (J. Mannsand L. Squire). Connectionist Models for Memory Disorders (J. Murre). Psychopharmacology of Human Memory (H. Curran and H.Weingartner). SECTION II: VARIETIES OF MEMORY DISORDER. The Amnesic Syndrome: Overview and Subtypes (M. O'Connor and M.Verfaillie). Theories of Anterograde Amnesia (A. Mayes). Retrograde Amnesia (M. Kopelman). Transient Global Amnesia (G. Goldenberg). Recovery of Memory Function in Neurological Disease (N. Kapur andK. Graham). Neuropsychological Impairments of Verbal Short-term Memory (G.Vallar and C. Papagano). Neuropsychological Impairments of Visual and Spatial Working Memory(S. Della Sala and R. Logie). Disorders of Semantic Memory (J. Snowden). The Cognitive Neuroscience of Confabulation: A Review and a Model(A. Gilboa and M. Moscovitch). Frontal Lobes and Memory (J. Baldo and A. Shimamura). Posttraumatic Amnesia and Residual Memory Deficit after Closed HeadInjury (H. Levin and G. Hanten). Schizophrenia (P. McKenna et al.). Memory and Emotional Disorder (T. Dalgleish and S. Cox). Psychogenic Amnesia (M. Kopelman). SECTION III: DEVELOPMENT AND MEMORY. Memory Development During the Childhood Years (S.Gathercole). Children with Intellectual Disabilities (S. Vicari and G.Carlesimo). Developmental Amnesias and Accquired Amnesias of Childhood (C.Temple). Memory in Elderly People (J. Kester et al.). The Memory Deficit in Alzheimer's Disease (J. Becker and A.Overman) Memory Disorders in Subcortical Dementia (J. Brandt and C.Munro). SECTION IV: ASSESSMENT AND MANAGEMENT OF MEMORY PROBLEMS. Assessment of Memory Disorders (B. Wilson). Separating Memory from Other Cognitive Disorders (D. Howieson andM. Lezak). Management and Remediation of Memory Problems in Brain-injuredAdults (B. Wilson). Assessment and Management of Memory Problems in Children (J.Middleton). Assessment and Intervention in Dementia of Alzheimer Type (L.Clare). Reducing the Impact of Cognitive Impairment in Dementia (B.Woods). External Memory Aids and Computers in Memory Rehabilitation (N.Kapur et al.). Emotional and Social Consequences of Memory Disorders (R.Tate). Author Index. Subject Index.

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Book SynopsisHoward P. Greenwald takes an incisive look at how class, race, sex, psychological state, type of health care, and available treatments affect one's chance of surviving cancer. Drawing on a ten-year survival study of cancer patients, he synthesizes medical, epidemiological, and psychosocial research in a uniquely interdisciplinary and eye-opening approach to the question of who survives cancer and why. Scientists, health care professionals, philanthropists, government agencies, and the public all agree that significant resources must be allocated to fight this dreaded disease. But what is the most effective way to do it? Greenwald argues that our priorities have been misplaced and calls for a fundamental rethinking of the way the American medical establishment deals with cancer. He asserts that prevention and experimental therapy have only limited value, whereas the availability of conventional medical care has a greater influence on cancer survival. Class and race become strikingly significant in predicting who has access to health care and thus can obtain medical treatment in a timely, effective manner. Greenwald counters the popular notion that personality and psychological factors strongly affect survival, and he underscores the importance of early detection. His research shows that health maintenance organizations, while sometimes prone to delays, offer low-income patients a better chance of ultimate survival. Greenwald pleads for immediate attention to the inadequacies and inequalities in our health care delivery system that deter patients from seeking early medical care. Instead of focusing on research and the hope for a breakthrough cure, Greenwald urges renewed emphasis on ensuring available health care to all Americans. In its challenge to the thrust of much biomedical research and its critique of contemporary American health care, as well as in its fresh and often counterintuitive look at cancer survival, Who Survives Cancer? is invaluable for policymakers, health care professionals, and anyone who has survived or been touched by cancer. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1992.

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Book SynopsisDr Taylor's book analyses the disease concept as it developed in medical history and seeks to clarify it with the help of concepts largely derived from logical class theories. A solution is proposed to the problem of how to distinguish between the class of 'patients' and the class of 'healthy persons' which corresponds to the actual diagnostic practices of doctors. The earliest theories of disease postulated concrete entities which exist independently of the body. The notion of disease entity has lost its original ontological connotations and instead its important feature has become the possession of a unitary and self-contained character. Dr Taylor describes the modern theories as essentially 'reactive' in character, that is the symptoms of a disease are the bodily reactions to the 'noxae'. After seeing the subject in its historical content, Dr Taylor goes on to discuss in detail the notion of the classification of diseases, making extensive use of modern views on the logic of classesTable of ContentsAcknowledgements; 1. Early notions of disease; 2. Ontological theories of disease; 3. Reactive theories of disease; 4. Source indicators and their perception; 5. Classes and classifications; 6. Morbidity; 7. Morbi; 8. Molecular morbi; 9. Summary; References; Name index; Subject index.

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Book SynopsisThis extremely important book is the comprehensive and authoritative independent consensus report of the British Nutrition Foundation''s Task Force on Obesity. The Task Force was invited by the Council of the British Nutrition Foundation to review the present state of knowledge of the causes, consequences, prevention and treatment of obesity, and to prepare a report and should it see fit, to draw conclusions, make recommendations and identify areas for future research. Obesity is an authoritative and definitive landmark publication covering all major aspects of this vitally important condition. Bringing together a huge wealth of research information from a wide variety of disciplines, in a well-presented, clear and carefully-edited format, Obesity is an indispensable guide for all personnel involved in the prevention and treatment of obesity, or for those studying and researching in this area. The book provides comprehensive coverage of the health risks of obesity, clinical assessmTable of ContentsTerms of reference. Obesity Task Force Membership. Acknowledgements. 1. Introduction (Dr Michele Sadler). 2. Health Risks of Obesity (Professor John Garrow). 3. Clinical Assessment of Obesity (Professor John Garrow). 4. Epidemiology of Obesity in the UK (Dr Ann Gehily). 5. Aetiology of Obesity I: Introduction (Dr Andrew Prentice). 6. Aetiology of Obesity II: Genetics (Professor Peter Kopelman). 7. Aetiology of Obesity III: Critical Periods for the Development of Obesity (Dr Mary Flynn, Ms Gail Goldberg, Dr Andrew Prentice, Dr Tim Cole). 8. Aetiology of Obesity IV: Metabolic Factors (Dr Andrew Prentice). 9. Aetiology of Obesity V; Macronutrient Balance (Dr Andrew Prentice). 10. Aetiology of Obesity VI: Appetite Control, Physiological Factors (Dr Andrew Prentice, Dr James Stubbs). 11. Aetiology of Obesity VII: Endocrine Causes (Dr Nick Finer, Dr Andrew Prentice). 12. Aetiology of Obesity VIII: Psychological Factors (Professor Jane Wardle). 13. Aetiology of Obesity IX: Dietary Factors. (Dr Andrew Prentice, Dr Susan Jebb). 14. Aetiology of Obesity X: Food Choice, Food Policy and Eating Patterns (Dr David Mela, Professor Christopher Ritson, Ms Sharon Kuznesof). 15. Aetiology of Obesity XI: Physical Inactivity (Professor Kenneth Fox). 16. Significance of within Person Weight Variation (Professor John Garrow). 17. Prevention of Obesity (Professor John Garrow). 18. Treatment of Obesity I: Introduction (Professor John Garrow, Ms Mary O'Kane). 19. Treatment of Obesity II: Dietary Treatment of Obesity (Professor John Garrow, Ms Mary O'Kane). 20. Treatment of Obesity III: Physical Activity and Exercise (Professor Kenneth Fox). 21. Treatment of Obesity IV: Behavioural Treatment (Professor Jane Wardle). 22. Treatment of Obesity V: Pharmacotherapy for Obesity (Professor Peter Kopelman). 23. Treatment of Obesity VI: Surgical Treatments (Professor John Garrow). 24. Treatment of Obesity VII: Resources and Evaluation (Professor John Garrow). 25. Suggestions of Further Reading. 26. Recommendations of the BNF Task Force on Obesity. Appendix : Answers to Questions from medical journalists. Glossary. References. Index.

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Book SynopsisInsulin resistance, defined as a reduced biological action of insulin, has emerged as a major factor in the development and progression of a number of common non-communicable diseases in man. The role of insulin resistance in the aetiology of type 2 diabetes is particularly well-established. However, insulin resistance has also come to be regarded as a key component of a broader syndrome of common metabolic defects that conspire to increase the risk of atherosclerotic coronary heart disease. The ramifications of insulin resistance now embrace many different medical specialties. The objective of this book is to summarize the current state of knowledge about insulin resistance. Section 1 (Pathophysiology of Insulin Resistance) considers the development of current concepts of insulin resistance. This is followed by a critical review of techniques for the assessment of insulin action in humans. The section concludes with an outline of current hypotheses concerning the molecular Table of ContentsSection 1. Pathophysiology of insulin resistance. . 1.1 Introduction. 1.2 Normal physiology. 1.2.1 Hormonal regulation of metabolism. . 1.2.2 The insulin receptor. 1.2.3 Post-binding events. 1.2.4 Glucose metabolism. . 1.2.5 Lipid metabolism. . 1.2.6. Protein metabolism. 1.2.7. Ion transport. . 1.3 The concept of insulin resistance. 1.3.1 Early studies of insulin action. 1.4 Definitions of insulin resistance. 1.5 Assessment of insulin action in vivo. 1.5.1 Fasting insulin concentration. 1.5.2 Dynamic tests - endogenous insulin. 1.5.3 Dynamic tests - exogenous insulin. 1.5.4 Mathematical modelling techniques. 1.5.5 The insulin suppression test. 1.5.6 The hyperinsulinaemic euglycaemic clamp technique. 1.6. Mechanisms of insulin resistance. . 1.6.1 Genetic causes of insulin resistance. . 1.6.2 Acquired causes of insulin resistance. . 1.6.3.Fetal origins hypothesis. . Further Reading. . Section 2. Insulin resistance in clinical medicine. 2.1 Clinical features. . 2.2 Factors influencing insulin sensitivity. . 2.2.1 Normal variation in insulin action. . 2.2.2 Sex. 2.2.3 Age. . 2.2.4 Physical activity. . 2.2.5 Tobacco. . 2.2.6 Alcohol. . 2.3. Physiological states of insulin resistance. 2.3.1 Puberty. . 2.3.2 Pregnancy. 2.3.4 The menopause. . 2.4 Severe insulin resistance syndromes. . 2.5 Insulin resistance and cardiovascular risk. 2.5.1 Syndrome X. 2.5.2 Obesity. . 2.5.3 Regional adiposity. . 2.5.4 Impaired glucose tolerance. . 2.5.5 Type 2 diabetes. . 2.5.6 Essential hypertension. 2.5.7 Dyslipidaemia. . 2.5.8 Endothelial dysfunction. . 2.5.9 Microalbuminuria. . 2.5.10. Hyperuricaemia. . 2.5.11 Impaired Fibrinolysis. 2.5.12 Polycystic ovary syndrome. . 2.5.13 Non-alcoholic steatohepatitis. 2.6 Other disorders associated with insulin resistance. . 2.6.1 Counter-regulatory hormone secretion. . 2.6.2 Endocrinopathies. . 2.6.3 Chronic renal failure. 2.6.4 Cirrhosis. . 2.6.5 Cardiac failure. . 2.7 Miscellaneous inherited disorders. 2.8 Drug-induced insulin resistance. Further Reading. . . Section 3. Management of insulin resistance and associated conditions. 3.1 Non-pharmacological measures. 3.1.1 Medical nutrition therapy. . 3.1.3 Alcohol. . 3.1.4 Tobacco. . 3.2 Drugs for type 2 diabetes. . 3.2.1 Biguanides. 3.2.2 Thiazolidinediones. . 3.2.3 Sulphonyulreas. . 3.2.4 Repaglinide. 3.2.5 a-glucosidase inhibitors. . 3.2.6 Insulin therapy. . 3.3 Anti-obesity drugs. . 3.4 Lipid-modifying drugs. . 3.5 Anti-hypertensive drugs. 3.6 Experimental therapies

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Book SynopsisPunctuated with remarkable case studies, this book explores extraordinary encounters between hermaphrodites and the medical and scientific professionals who grappled with them in late 19th-century France and England. It takes us inside the doctors’ chambers to see how and why medical and scientific men constructed sex, gender, and sexuality.Trade ReviewIn her study of the medical response to human hermaphrodites, Alice Dreger draws on over 300 scientific and medical commentaries in France and Britain, of which over half the cases reported occurred between 1860 and 1915...As Dreger observes, there was no single opinion among doctors or the public at large about which traits were essentially male or female, or even what they might signify. In Britain, female facial hair was likely to be associated with insanity, while in France it was more likely to be seen as a mark of remarkable strength. Other interesting differences emerge...Hermaphrodites and the Medical Invention of Sex is richly researched, detailed and fascinating. -- Angelique Richardson * Times Literary Supplement *This is a well-researched, sober history of a problem that Alice Dreger shows has directly affected more people than we might think and which shapes the sense of sexual identity of us all...Avoiding preachy judgementalism, Dreger shows how deeply ingrained are our assumptions about gender normality (sexual anatomy is destiny) and on how flimsy a basis they have been grounded. The book offers us all a lesson in self-awareness. -- Roy Porter * Nature *Alice Dreger ascribes the growing visibility of the hermaphrodite to Victorian anxieties about gender-blurring social phenomena, including homosexuality and feminism, as well as to improvements in medical science. During the Victorian era, Dreger argues, a greater number of women gained access to gynecological care, and as a result, infant anatomy came under more professional scrutiny; medical journals of the period, widely accessible for the first time, publicized anomalous cases. Scientific knowledge of embryological development began turning the one-time monster or marvel into, in the words of the turn-of-the-century French doctor Xavier Delore, 'a scientific matter and a degraded organism.' -- Emily Nussbaum * Lingua Franca *Dreger...has found a rich mine in the clinical case histories of hermaphroditism, which outline the physicians' complex struggle to find a foolproof way of fitting individuals into a binary sexual scheme. -- Laurence A. Marschall * The Sciences *This engaging, well-written book will benefit scholars and lay readers interested in the history of sex, sexuality, gender, and medicine. The book traces the evolution of what makes a person male or female and shows how the answer has changed depending on when the question was asked and where it was asked. Dreger has succeeded in compelling the reader to ask the same question. -- Patricia Y. Fechner * New England Journal of Medicine *The historic records of [hermaphrodites]...are carefully documented by this meticulous author and merit study...To read this book is to become aware of the tremendous complexity of human sexuality and gender identity--beyond genitals, hormones, enzymes, and even chromosomes and genes. Behavior, feelings, and values blend with intellect and how each individual is sexually drawn to each other. -- Domeena C. Renshaw, MD * Journal of the American Medical Association (JAMA) *Most people have heard the term 'hermaphrodite,' but aren't quite sure what it means. [This book serves] as an introduction to that topic, bringing the voices of intersex people...into dialogue with...experts. Dreger also includes many fascinating historical photographs. Her stories of detective doctors presiding over 'doubtful-sex gatherings' show how 'again and again, consultations with fellow medical men almost invariably, rather than clearing up confusion, resulted instead in deeper and broader doubt...Medical men often discovered that too many diagnosers spoiled the certainty'...What makes [this book] important and provocative also makes [it] a little dangerous because [it] is so ahead of [its] time. -- Leonore Tiefer * Women's Review of Books *This is a very strange and a very good book, tackling an important topic with humanity, and in a readable style. This is a subject where biology, psychology and medical authority conflict, and where prudery, ignorance and dogmatism drive people to suicide. Dreger deals with the history of definitions of man or woman by myth and by medicine, and provides case histories, together with photographs of the problematic genitalia...As biologists, we should treasure variation--if you doubt that for human sexuality, read this book. -- Jack Cohen * Biologist *Through a collection of dramatic and moving medical case histories from the late 19th and early 20th centuries, Dreger argues that the medical profession increasingly claimed the knowledge and authority to determine 'true' gender and to effectuate such determination by surgical means...[This] is a wonderful example that historical writing is not merely about revisiting the past, but reshaping the future. This book will prove fascinating and moving reading for those concerned with the ways in which biomedical knowledge is deployed in the service of the cultural regulation of gender and sexuality. -- Vernon Rosario * Harvard Gay and Lesbian Review *[A] perceptive, erudite and superbly-written book...Concentrating on late-nineteenth- and early twentieth-century Britain and France, Dreger analyses how defining and 'managing' hermaphroditism were crucial to the destabilization as well as a simultaneous--and only seemingly paradoxical--reinforcement of the sexual division of humanity into male and female. In a surprisingly well-integrated epilogue of the book, she establishes that present-day treatment of hermaphrodites in America, in spite of phenomenal advancements in surgical technologies and theoretical understanding of sexual physiology, continues to be guided by ideas about the nature and meaning of sex that would not have seemed unfamiliar to fin-de-siècle doctors. -- Chandak Sengoopta * Medical History *In her compelling, highly engaging and carefully researched book, Dreger charts the individual stories of many hermaphrodites--often with accompanying photographs...[It is] vital reading for feminists in that [it] offers detailed illustrations of scientific and medical complicity with social norms of 'sex' and 'gender', and raises important questions about how cultures enforce ideas about 'normal' bodily conditions and behaviours. -- Celia Kitzinger * Feminism & Psychology *Dregerhas produced a well-written, lucid and sensitive account of the medical treatment of hermaphrodites from the latter half of the nineteenth century through to the present day...Dreger's description of the way modern doctors persist in assuming that they, and not the individual concerned or society, have the right to define an individual's sex are particularly illuminating. This book will be immensely interesting to historians working in this area and anyone concerned with intersexuality. -- Helen Blackman * Social History of Medicine *In her book, Alice Dreger sets out to convince the reader that the history of hermaphrodites, or people of ambiguous sex, is an important and interesting topic, and she more than accomplishes her goal. Not only does she deliver, but she does so with grace, ease, and compassion. This is a marvelous book, an unexpected surprise which is as readable and engaging as it is informative...Within pages of opening the book, I was enthralled. -- H. Hughes Evans * Journal of the History of Medicine *Traces the history of the biomedical treatment of hermaphrodites during what Dreger calls the "Age of Gonads."...She offers the reader a complex and lucid account of the process by which hermaphrodites moved from a public space (some as performers in traveling circuses and shows) to a private space where all hermaphrodite identities became increasingly shaped and defined by physicians who gained in power and prestige by intervening in the lives of these individuals...Dreger makes a convincing argument for a new approach to individuals born with ambiguous genitalia. -- Heather Harris * Journal of the History of Biology *Dreger has identified an important and suggestive topic, not only in the history of medicine, but for cultural history more generally. Hermaphrodites were, after all, only among the most striking members of the parade of anomalies that engaged the attention of both specialists and the general public at the turn of the century. Any liminal creature was apt to trigger anxieties about the defense of social as well as natural boundaries, and any breach of the barriers that divided the sexes was particularly unnerving. -- Harriet Ritvo, Massachusetts Institute of TechnologyThe casual browser who picks up this book and thinks that hermaphrodism has nothing to do with her or him is mistaken. Dreger illuminates the process by which medicine appropriated to itself the authority first to interpret and then to 'fix' sex difference. This is a specific example of a widespread but largely invisible phenomenon, in which cultural agendas are disguised as scientific authority. The medical abuse of individuals born with atypical sex anatomy in fact serves everyone who holds the unscientific belief that the world is divided neatly into two clearly distinguished sexes. Dregerhas written a book that should interest not only medical historians, professionals concerned with intersexuality, and intersexuals themselves, but everyone who thinks she knows her sex. -- Cheryl Chase, Director Intersex Society of North AmericaIn Hermaphrodites and the Medical Invention of Sex, Alice Dreger illuminates life stories that had been recast, subsumed, and ultimately 'disappeared' by the medical profession...Dreger's book is clearly written and easy to read. Fascinating, entertaining, disturbing, and thought-provoking all at once, it makes one ask, 'what is the difference between a male and a female?' and even more unsettling, 'why does it matter so much in our society.' * Synapse: University of California San Francisco Weekly *This fascinating book consists of numerous case studies on hermaphrodites (intersexes) and their abusive treatment by the medical and scientific community during the late 19th century and early 20th centuries in Britain and France... Dreger believes that by studying the cultural history and climate that prevailed relating to intersexuality at the turn of the last century, we may be better able to understand the concept of gender, sex, and sexuality. There are interesting sections on famous hermaphrodites and hermaphrodites in love. -- H.S. Pitkow * Choice *This history is important to our understanding of how the categories of "male" and "female" have come to be understood in the medical community. This history is also relevant to the current questioning of modern intersex medicine…Overall, this book is well written and considers important influences of history on the treatment of hermaphrodites that have been previously ignored. -- Amy B Wisniewski, Ph.D. * The Journal of Nervous and Mental Disease *In Hermaphrodites and the Medical Invention of Sex, Alice Domurat Dreger looks at the debates concerning intersexed peole which circulated in the medical communities of France and Britain in the late 19th and early 20th centuries. In so doing, Dreger has also offered insight into our own fin-de-siècle quandaries about the limits of usefulness of the concepts of sex and gender as categorizations of human beings...Overall, Hermaphrodites and the Medical Invention of Sex is an excellent book. -- Holly Devor * Journal of Sex Research *Table of Contents* Acknowledgments * Prologue: But My Good Woman, You Are a Man! * Doubtful Sex * Doubtful Status * In Search of the Veritable Vulva * Hermaphrodites in Love * The Age of Gonads * Epilogue: Categorical Imperatives * Notes * Index

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Book SynopsisMoses Chao argues that activity in the peripheral nervous system predicts the onset of neurological and psychiatric conditions such as Parkinson’s disease, autism, and dementia. Responsible for regulating a range of involuntary bodily processes and for detecting smells, sounds, and touch, the peripheral system may also be a key to better health.Trade ReviewA sweeping tour…Chao proves to be a capable guide, and at many points it feels as if he is a personal mentor sitting at the front of a small classroom, expounding on his years of experience. -- Sara Manning Peskin * American Scientist *[An] eye-opening debut…Chao makes a convincing case that scientists would do well to focus research on the [peripheral nervous system] and its relationship with disease. * Publishers Weekly *An excellent guide to an important topic. The peripheral nervous system has long been seen as a second-class citizen with respect to the brain, but Chao shows that this is deeply misguided: without the periphery, the brain would be unable to sense the world, act in it, or even survive. -- Joseph E. LeDoux, author of The Four Realms of Existence: A New Theory of Being HumanA long-awaited book, revealing just how deeply the brain is embedded in the body. By illuminating the neuronal and humoral systems that coordinate our physiology—both with and without the brain—Chao shows that the peripheral nervous system is not at all peripheral in terms of importance. -- György Buzsáki, author of The Brain from Inside OutEngaging and well-written. Chao makes a compelling case for the role the peripheral nervous system plays in contributing to diseases that affect the central nervous system, delightfully weaving together historical accounts of neurological diseases with cutting-edge science. -- Ahmet Hoke, Director of the Division of Neuromuscular Diseases, Johns Hopkins University School of Medicine

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Book SynopsisThere are more than 500,000 carpal tunnel surgeries done annually in the United States but approximately 30 percent of these patients will be no better as a result. The truth is, most physicians are too quick to consider surgery as the first line of defence against carpal tunnel and other repetitive-strain injuries. In this comprehensive guide to recognizing and treating these debilitating conditions, Dr. Scott Fried takes a strong position against surgery and offers self-healing alternatives that have better results. From understanding the signs and symptoms at an early stage to modifying work and lifestyle from proven alternative therapies and helpful medications to nutrition and exercise, The Carpal Tunnel Helpbook provides authoritative advice and practical, up-to-date information to spare many patients the ordeal of surgery to treat their injuries.

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