Clinical and internal medicine Books

Book SynopsisThe sixteenth annual symposium of the Society for the Study of Inborn Errors of Metabolism was held in Bristol from 12th to 14th July, 1978. About 25 invited speakers and 150 participants came from many parts of Europe and North America to consider the topic, 'Inherited Disorders of Carbohydrate Metabolism'. Although some aspects of these disorders have formed part of the programme of previous symposia organized by the Socie­ ty, this was the first attempt to discuss them in a systematic manner. The subject, carbohydrate disorders, embraces both familiar and well documented conditions and some lesser known aspects of genetic disease. In all of these there remains much to be learnt about clinical and laboratory diagnosis, treatment, biochemical screening and pathogenesis. Thus one aim of the Society, to combine clinical and scientific interest, can rarely have been better achieved in a single symposium. Since the programme included diseases from six different areas of car­ bohydrate metabolism and contained so many distinguished speakers, it is impossible to highlight the more important aspects of this symposium within a short space. Each section made a notable contribution to knowledge and, when time was available, lively discussions ensued which have been recorded in the book. However, we wish to mention our two special lectures, because they recognise people to whom the Society owes a great deal. The Milner lecture has been given for the past 6 years as a tribute to Mr J.Table of ContentsSection One Introduction.- 1 Carbohydrate metabolism and its regulation — The Milner Lecture.- Section Two Disorders of Carbohydrate Absorption.- 2 Basic causes of carbohydrate malabsorption.- 3 Clinical aspects of disordered carbohydrate absorption.- Section Three Disorders of Galactose Metabolism.- 4 Galactose metabolism, hereditary defects and their clinical significance.- 5 Clinical aspects of Galactosaemia.- 6 How long should galactosaemia be treated?.- 7 Pregnancy in classical galactosaemia.- 8 Screening for galactosaemia.- 9 Prenatal diagnosis of classical galactosaemia.- 10 Discussion.- Section Four Disorders of Fructose Metabolism.- 11 Clinical and genetic studies of disorders in fructose metabolism.- 12 Pathogenic mechanisms of disorders in fructose metabolism.- 13 Discussion.- Section Five Disorders of Pyruvate Metabolism.- 14 Pathways and regulation of pyruvate metabolism.- 15 Pyruvate dehydrogenase deficiencies.- 16 Pyruvate carboxylase deficiency, studies on patients and on an animal model system.- Section Six Glycogen Storage Diseases.- 17 Recent advances and problems in the glycogen storage diseases.- 18 Hepatic glycogenosis: diagnosis and management — The F. P. Hudson Memorial Lecture.- 19 Recent work on treatment of Type I glycogen storage disease.- 20 Pre- and postnatal diagnosis of glycogen storage disease.- 21 Type VI glycogenosis: identification of subgroups.- 22 Discussion.- Section Seven Genetic Aspects of Diabetes.- 23 Clinical studies of the inheritance of diabetes mellitus.- 24 HLA antigens and diabetes.- 25 Juvenile diabetes and optic atrophy.- 26 Discussion.

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Book Synopsis1. Atherosclerosis.- 2. Gastrointestinal Regulatory Peptide Control of Insulin Secretion and its Relevance to Diabetes Mellitus.- 3. Insulin Resistance.- 4. Diabetes Mellitus and Atherosclerosis.- 5. Risk Factors for Atherosclerosis in Diabetes Mellitus.- 6. Lipid Metabolism and its Disorders in Diabetes Mellitus.- 7. Diabetes Mellitus and Raised Blood Pressure.- 8. Insulin and Atherosclerosis.- 9. The Possible Role of Glycation in the Pathogenesis of Atherosclerosis.- 10. Haemostatic Disorders in Diabetes Mellitus.- 11. Proteinuria in Relation to Cardiovascular Mortality and Morbidity in Diabetes Mellitus.- 12. Non-ischaemic Heart Disease in Diabetes Mellitus.- 13. Experimental Atherosclerosis and Diabetes Mellitus.Trade Review' This book is of interest to clinicians of different specialties participating in the management of diabetic patients, but it is also good reference source for researchers in this field. ' Journal of the Royal Col. of Phy. of London 26:4 1992 '....but I can thoroughly recommend it to cardiologists, diabetologists, endocrinologists, general physicians, geriatricians, pathologists and vascular surgeons.' Age and Ageing 22:1 1993 'I will find the book a useful source. I recommend the book to those who are interested in the all too common problem that it is atherosclerosis that most commonly leads to the clinical morbidity and early death of our diabetic patients.' The Ulster Medical Journal 61:1 1992 Table of Contents1. Atherosclerosis.- 2. Gastrointestinal Regulatory Peptide Control of Insulin Secretion and its Relevance to Diabetes Mellitus.- 3. Insulin Resistance.- 4. Diabetes Mellitus and Atherosclerosis.- 5. Risk Factors for Atherosclerosis in Diabetes Mellitus.- 6. Lipid Metabolism and its Disorders in Diabetes Mellitus.- 7. Diabetes Mellitus and Raised Blood Pressure.- 8. Insulin and Atherosclerosis.- 9. The Possible Role of Glycation in the Pathogenesis of Atherosclerosis.- 10. Haemostatic Disorders in Diabetes Mellitus.- 11. Proteinuria in Relation to Cardiovascular Mortality and Morbidity in Diabetes Mellitus.- 12. Non-ischaemic Heart Disease in Diabetes Mellitus.- 13. Experimental Atherosclerosis and Diabetes Mellitus.

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Book SynopsisPeritoneal dialysis represents an internal technique for membrane are becoming apparent. Studies of peritoneal blood purification. In this dialyzer the blood path, the dialysis increase understanding of the anatomy and phy­ membrane and the dialysate compartment are provided by siology of biological membranes and the factors influencing nature. The developments of chronic peritoneal catheters, the passive movement of solutes across the microcirculation and related structures. Peritoneal dialysis provides a 'win­ automated cycling equipment, solution preparation by reversed osmosis, manipulations of transport with drugs dow' to the visceral microcirculation in animals and hu­ and the experiences with continuous ambulatory peritoneal mans. dialysis and continuous cycling peritoneal dialysis have Peritoneal dialysis may be useful to treat problems other increased the interest in peritoneal dialysis. Publications than renal failure. Beneficial effects in the treatment of related to peritoneal dialysis probably exceed 400 annually. dysproteinemias, psoriasis, hypothermia, and many meta­ Peritoneal Dialysis International (formally Peritoneal Dialy­ bolic problems have been reported. The intraperitoneal sis Bulletin) the official journal of the International Society administration of chemotherapeutic agents draws upon and for Peritoneal Dialysis is a journal solely devoted to contributes to our understanding of peritoneal dialysis.Trade Review`This book can be recommended to any nephrologist with a strong interest in peritoneal dialysis.' R. Gutman, Dialysis and Transplantation, February 1990Table of Contents1. History of peritoneal dialysis.- 2. The peritoneal dialysis system.- 3. Role of the peritoneal microcirculation in peritoneal dialysis.- 4. Peritoneal cavity lymphatics.- 5. Peritoneal ultrastructure.- 6. Transport kinetics.- 7. Ultrafiltration with peritoneal dialysis.- 8. New approaches to intermittent peritoneal dialysis therapies.- 9. Continuous ambulatory peritoneal dialysis.- 10. Continuous cyclic peritoneal dialysis.- 11. Pharmacologic alteration of peritoneal transport rates.- 12. Comments on dialysis solution, antibiotic transport, poisonings, and novel uses of peritoneal dialysis.- 13. Nutritional management of patients undergoing peritoneal dialysis.- 14. Peritonitis.- 15. Complications other than peritonitis or those related to the catheter and the fate of uremic organ dysfunction in patients receiving peritoneal dialysis.- 16. Peritoneal dialysis access.- 17. Peritoneal dialysis in children.- 18. Peritoneal dialysis in diabetics.- 19. The stability and kinetics of peritoneal mass transfer.- 20. The USA CAPD registry. Characteristics of participants and selected outcome measures for the period January 1, 1981, through August 31, 1987.- 21. Peritoneal dialysis results in the EDTA registry.- 22. Quality of life in peritoneal dialysis patients: instruments and application.- Index of subjects.

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Table of ContentsThe 23rd Annual Symposium of the SSIEM: Liverpool.- to recombinant DNA.- Human biochemical genetics of enzyme proteins in the new age of molecular genetics.- Direct DNA analysis in family studies.- Application and limitations of direct DNA analysis in genetic prediction.- DNA analysis for ornithine transcarbamylase deficiency.- Molecular genetics of PKU.- Human DNA repair defects.- Molecular basis of ai-antitrypsin deficiency and its potential therapy by gene transfer.- Direct alteration of a gene in the human genome.- Diabetes mellitus, atherosclerosis, and the 5’ flanking polymorphism of the human insulin gene.- Workshop on Screening for Congenital Adrenal Hyperplasia (steroid 21-hydroxylase deficiency).- Clinical aspects of congenital adrenal hyperplasia: early diagnosis and prognosis.- Biochemical aspects of congenital adrenal hyperplasia.- Large-Scale Pilot Studies.- Review of CAH screening programmes and the Scottish experience.- Neonatal screening programme for congenital adrenal hyperplasia in a homogenous Caucasian population.- Neonatal screening for congenital adrenal hyperplasia: a pilot study in France.- Existing Clinical Diagnoses.- Congenital adrenal hyperplasia in Birmingham: a retrospective analysis (1958-1985).- Prevalence of adrenal 21-hydroxylase deficiency in neonates born in the West Midlands: a retrospective study.- Clinical Symposium - Phenylketonuria.- and explanation.- Maternal phenylketonuria.- Dietary problems of phenylketonuria: effect on CNS transmitters and their possible role in behaviour and neuropsychological function.- Diagnosis in relationship to treatment of hyperphenylalaninaemia.- Problems related to diet management of maternal phenylketonuria.- Short Communications.- Preface and Free Communications.- Molecular biology of phenylalanine hydroxylase.- Hepatic phenylalanine hydroxylase and dietary tolerance in hyperphenylalaninaemic patients.- Phenylalanine metabolites in treated phenylketonuric children.- Magnesium-deficient rickets in a phenylketonuric patient on dietary treatment.- Termination of strict diet in phenylketonuria: neurophysiological, psychological and biochemical studies.- Effects of stopping phenylalanine-restricted diet on intellectual progress of children with phenylketonuria.- Maternal hyperphenylalaninaemia: dietary treatment during pregnancy.- Maternal hyperphenylalaninaemia in Israel.- Maternal phenylketonuria with increased tyrosine supplements.- Screening for phenylketonuria in Yugoslavia (SR Croatia) 1979–1984.- Incidence of phenylketonuria and hyperphenylalaninaemia in a sample of the Turkish newborn population.- Atypical phenylketonuria with mild mental retardation caused by tetrahydrobiopterin deficiency in a Chinese family.- Dihydropteridine reductase deficiency: clinical, biochemical and therapeutic aspects.- Partial dihydropteridine reductase deficiency and mental retardation.- Urine amino acid analysis by HPLC in the investigation of inborn errors of metabolism.- Plasma amino acid patterns in critically ill children.- Treatment of hereditary tyrosinaemia (fumarylacetoacetase deficiency) by enzyme substitution.- Presentation of the data of the Italian registry for oculocutaneous tyrosinaemia.- A new case of hyperlysinaemia with saccharopinuria.- Failure of early diazepam treatment in a neonate with non-ketotic hyperglycinaemia.- Gyrate atrophy of the choroid and retina: 3 cases in one Italian family.- Methylenetetrahydrofolate reductase and methyltetrahydrofolate methyltransferase in human fetal tissues and chorionic villi.- Kinetic studies on the glucose-6-phosphate transport system in rat hepatic microsomal membrane.- Long term cornstarch therapy in glycogen storage disease types I, lb and III.- Galactose-l-phosphate-uridyl transferase activity in chorionic villi: a first trimester prenatal diagnosis of galactosaemia.- Molecular heterogeneity of McArdle disease.- Decreased affinity of phosphorylase ? for glucose-1 -phosphate in polymorphonuclear leukocytes of patients with glycogenosis type VI.- The diagnosis and treatment of a patient with medium-chain acyl-CoA dehydrogenase deficiency: overnight fasting does not result in the expected urinary metabolite profile.- A new case of familiar C6-C14 dicarboxylic aciduria with favourable evolution.- Pyruvate carboxylase responsive to ketosis in a multiple carboxylase deficiency patient.- Neonatal screening for biotinidase deficiency: an update.- GM2 gangliosidosis with hexosaminidase A and B defect: report of a family with motor neuron disease-like phenotype.- A comparison between hepatocytes and macrophages of sphingomyelin, cholesterol and acid lipase in various types of Niemann-Pick disease.- Juvenile dystonia without vertical gaze paralysis: Niemann-Pick type C disease.- Pre- and postnatal diagnosis of the cerebro-hepato-renal (Zellweger) syndrome via a simple method directly demonstrating the presence or absence of peroxisomes in cultured skin fibroblasts, amniocytes or chorionic villi fibroblasts.- Impaired cholesterol side chain cleavage activity in liver from patients with cerebro- hepato-renal (Zellweger) syndrome in relation to the accumulation of di- and trihydroxycoprostanoic acid in serum.- Deficiency of dihydroxyacetonephosphate acyltransferase and catalase-containing particles in patients with infantile Refsum’s disease.- Peroxisomal abnormalities in rhizomelic chondrodysplasia punctata.- Cytogenetic studies of three families with ataxia-telangiectasia (Louis-Bar syndrome).

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Book SynopsisThe first symposium of the Society for the Study ofInborn valuable overview of advances in the application of Errors of Metabolism (SSIEM) on the organic acid urias chemical analysis of amniotic fluid to their early prenatal was held in Leeds in 1971 and published by the Society in diagnosis. The continuing complexity of diagnosis, 1972 (the 9th Annual SSIEM Symposium). Although biochemistry and aetiology ofthe dicarboxylic acid urias relatively few of these disorders were recognized at that has been admirably reduced by the papers from Dr time, the symposium was prompted by the then recent Gregersen and Dr Goodman, with Dr Goodman clearly identification between 1966 and 1970 of isovaleric identifying the primary defect in the polycystic variant of acidaemia, methylmalonic aciduria, propionic aci- multiple acyl CoA dehydrogenase deficiency ("glutaric daemia, pyroglutamic aciduria and 3-methylcrotonyl- aciduria type II") as a deficiency of electron transfer glycinuria. Identification and diagnosis of diseases of this flavoprotein (ETF) dehydrogenase. Dr Engel's paper kind had greatly improved primarily through the also provides a useful overview from currently available application of gas chromatography and mass spectro- data of the place of L-carnitine in the organic acid urias, metry to medicine, although the complexity of the an area in which rapid developments are occurring. The underlying biochemistry and the genetic heterogeneity of emerging understanding of the aetiologies of the the organic acidurias was not then realised.Table of ContentsPreface.- Section I: Clinical aspects: management and outcome.- Neonatal management of organic acidurias. Clinical update (Hudson Memorial Lecture).- Long term outcome of organic acidurias: survey of 105 French cases (1967-1983).- The management and long term outcome of organic acidaemias.- Prenatal diagnosis of the organic acidurias.- Symptoms and signs in organic acidurias.- Section II: Dicarboxylic acidurias and acyl-CoA dehydrogenase deficiencies.- Fatty acyl-CoA dehydrogenase deficiency: enzyme measurement and studies on alternative metabolism.- Glutaric acidaemia type II (multiple acyl-CoA dehydrogenation deficiency).- Carnitine metabolism and inborn errors.- Gas chromatography—mass spectrometry (GC—MS) diagnosis of 2 cases of medium chain acyl-CoA dehydrogenase deficiency.- The differential diagnosis of dicarboxylic aciduria.- Animal models for dicarboxylic aciduria.- Section III: Disorders of the respiratory chain and the lactic acidaemias.- Mitochondrial oxidative phosphorylation and respiratory chain: review.- Mitochondrial myopathies: disorders of the respiratory chain and oxidative phosphorylation.- Lactic acidaemia.- Pyruvate carboxylase deficiency.- Organic acids in urine of patients with congenital lactic acidoses: an aid to differential diagnosis.- Section IV: A new disorder: 4-hydroxybutyric aciduria.- Clinical review.- Biochemical findings.- Enzymology and mode of inheritance.- Section V: Short Communications.- Preface to Short Communications.- Free Communications.- Electron-transferring flavoprotein deficiency in the multiple acyl-CoA dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria.- Glutaric aciduria type II: multiple defects in isolated muscle mitochondria and deficient ?-oxidation in fibroblasts.- Glutaryl CoA dehydrogenase activity determined with intact electron-transport chain: application to glutaric aciduria type II.- Medium chain acyl-CoA dehydrogenase deficiency: apparent Km and Vmax values for fibroblast acyl-CoA dehydrogenase towards octanoyl-CoA in patient and control cell lines.- Mitochondrial myopathy with partial cytochrome oxidase deficiency and impaired oxidation of NADH-linked substrates.- L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria.- An evaluation of urine lactate for detection of inborn errors of metabolism.- Metabolic acidosis versus a compensation of respiratory alkalosis in four children with Leigh’s disease.- Chemical diagnosis of dihydrolipoyl dehydrogenase deficiency.- 3-Hydroxy-3-methylglutaric, 3-methylglutaconic and 3-methylglutaric acids can be non-specific indicators of metabolic disease.- Different organic acid patterns in urine and in cerebrospinal fluid in a patient with biotinidase deficiency.- Biotinidase deficiency: the possible role of biotinidase in the processing of dietary protein-bound biotin.- Biotin-responsive multiple carboxylase deficiency (MCD): deficient biotinidase activity associated with renal loss of biotin.- Organic acids in urine: sample preparation for GC/MS.- Experience with prenatal diagnosis of propionic acidaemia and methylmalonic aciduria.- Methylmalonic aciduria with homocystinuria.- Two cases of ß-ketothiolase deficiency: a comparison.- L-Glyceric aciduria (primary hyperoxaluria type 2) in siblings in two unrelated families.- The antenatal diagnosis and aid to the management of hereditary tyrosinaemia by use of a specific and sensitive GC—MS assay for succinylacetone.- The enzyme defects in hereditary tyrosinaemia type I.- The possibility for prenatal diagnosis of PKU by linkage analyses based on phenylalanine hydroxylase locus specific DNA-polymorphisms.- Complementation between argininosuccinate synthetase-deficient and argininosuccinate lyase-deficient fibroblasts depends on intercellular communication.- Molecular lesion of non-ketotic hyperglycinaemia.- Prolidase deficiency: detection of cases by a newborn urinary screening programme.- Type Ib glycogen storage disease: an in vivo and in vitro study of two cases.- The lactate concentration of the urine, a parameter for the adequacy of dietary treatment of patients with glucose-6-phosphatase deficiency.- Sorbitol dehydrogenase deficiency in a family with congenital cataracts.- Thiamin-responsive megaloblastic anaemia: a disorder of thiamin transport?.- Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms.- Steroid sulphatase deficiency. Steroid sulphatase and arylsulphatase C determination in normal and affected fibroblasts.- Steroid sulphatase deficiency is present in patients with the syndrome’ ichthyosis and male hypogonadism’ and with’ Rud syndrome’.

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Book SynopsisThe study of inherited metabolic disease became a subject of more than academic interest in 1953 when Bickel, Gerrard and Hickmans dis­ covered that the totally disabling consequences of phenylketonuria could be prevented if treatment was instituted in the first months of life. This required the widespread screening of all newborn babies and 7 years later this had been successfully achieved in the United King­ dom. The next 10 years was a period of consolidation: screening methods were improved and extended to include other disorders; treatment of phenylketonuria was vastly improved with the stimulus of the increasing numbers of patients being detected, and research into new forms of therapy for some of the other disorders being detected has been initiated. The success of this scheme is illustrated by the remarkable achievement reported by the Phenylketonuria Registry referred to in the present volume. But at what cost has this progress been made? It is unnecessary to discuss the financial cost for many of the developments would not have been started if their economic value in the system of health care had not been unequivocally established.Table of ContentsThe Nature and Size of the Problem.- 1 The need for a national policy for the management of inherited metabolic disease.- 2 Genetic screening and allied services: structure, process and objective.- Present Methods of Management.- 3 The role of the paediatrician.- 4 Management of dietary treatment in the home.- 5 Residential management.- Community Reaction to Present Practice.- 6 Parent reaction to medical care and screening.- 7 Screening for Tay—Sachs disease.- 8 Genetic counselling clinics.- 9 The coming of the second genetic code: eugenic abortion in the United Kingdom.- Aspects of Management Requiring Central Policy.- 10 The basis for prescriptive screening.- 11 Resources for nutritional treatment: basic principles and a national ‘Food Bank’.- 12 Detection of heterozygotes.- 13 Prenatal diagnosis.- 14 The phenylketonuria register for the United Kingdom.- 15 Computerized central registers.- 16 Mechanized storage and retrieval of information.- 17 Computer-aided diagnosis of inherited metabolic disease.- The Fourth Milner Lecture.- 18 The biochemical autopsy: a tool for studies of genetically-determined brain disorders.

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Book SynopsisThe rapid growth of immunology has greatly increased our understanding of disease; this growth has also generated a subject which at times appears separated from some of the basic medical sciences. Recent studies in the areas of purine metabolism and of polymorphonuclear neutrophil phago­ cyte function have, however, linked immunology and clinical medicine with biochemistry. The precise defects of the inborn errors of metabolism have now provided good evidence for the importance of purine metabolism specifically the enzymes adenosine deaminase and nucleoside phosphorylase in lymphocyte function. In view of this and the steady advance of clinical and biochemical investigation of the polymorphonuclear neutrophil phago­ cyte, it appeared timely to review the inborn errors of immunity and phagocytosis at the fifteenth annual symposium of the Society for the Study of Inborn Errors of Metabolism at Elsinore, Denmark on September II-14th, I~77. The papers presented at that meeting form the basis of this volume which brings together contributions from immunologists, biochemists and clinicians. This interdisciplinary communication should be helpful to those concerned with immune function in their patients or in the laboratory. The book is divided into four sections, One: defects of cell-mediated immunity, Two: enzyme defects and immunodeficiency, Three: disorders of non-specific immunity and Four: screening for immunodeficiency. Section One contains two reviews, one on immunodeficiency from Robert Good's group in New York and another on the genetics of the immune system from Arne Svejgaard of Copenhagen.Table of ContentsSection One Defects of Cell-mediated Immunity.- 1 Immunodeficiency diseases — a review.- 2 Genetics of the immune system.- Section Two Enzyme Defects and Immunodeficiency.- 3 Inborn errors of specific immunity: adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency — The Milner Lecture.- 4 Adenosine deaminase deficiency: enzyme replacement therapy and investigations of the biochemical basis of immunodeficiency.- 5 Prenatal diagnosis and heterozygote detection in adenosine deaminase deficiency.- 6 Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase.- 7 Purine nucleoside phosphorylase deficiency associated with cellular immunodeficiency: immunological studies during treatment.- 8 Purine nucleoside phosphorylase deficiency associated with cellular immunodeficiency: metabolic studies during treatment.- 9 Severe combined immunodeficiency with B lymphocytes: a selective defect of precursor T cells.- 10 Purine metabolism and the control of lymphocyte proliferation. Effects of exogenous adenosine on normal human lymphocytes.- 11 Activity of adenosine deaminase and purine nucleoside phosphorylase in lymphocytes of man, horse and cattle.- 12 Ageing and activities of purine metabolizing enzymes in leukocytes.- 13 Immune function in Down’s syndrome.- Section Three Disorders of Non-specific Immunity.- 14 Morphological and biochemical alterations of polymorphonuclear neutrophil (PMN) leukocytes from patients with inborn errors of phagocytic function: a comprehensive review.- 15 Experimental approaches to the role of mononuclear phagocytes in non-specific immunity.- 16 Molecular bases of the metabolic excitability of phagocytes.- 17 Chronic granulomatous disease — biochemistry with special reference to oxygen metabolism.- 18 The protective role of glutathione.- 19 Defective initiation of the metabolic stimulation in phagocytizing granulocytes.- 20 Modification of genetic expression in phagocytes.- 21 Neutrophil granulocyte chemotaxis in a reversible Boyden chamber.- 22 Simplified tests of leukocytic function.- 23 Antigen-induced neutrophil dysfunction in a patient with chronic eczema, recurrent ‘cold’ staphylococcal infections and hyperimmunoglobulinaemia E.- 24 Lack of myeloperoxidase-mediated iodination in granulocytes from a patient with generalized pustular psoriasis.- 25 Functional characteristics of neutrophil granulocytes from children with recurrent respiratory infections.- 26 Pneumocystis carinii infection in a girl with chronic granulomatous disease treated with transfusions of granulocytes.- Discussion.- Section Four Screening for Immunodeficiency.- Round Table Discussion.

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Book SynopsisFollowing the pattern of previous years the 11th symposium of the S.S.I.E.M. held in the beautiful sylvan surroundings of Sussex Univ­ ersity, concentrated on a relatively small section of the field of inborn errors. The subject chosen-Inborn Errors of Skin, Hair and Con­ nective Tissue, was a highly topical one. Intensive research during the last few years particularly on the structure and disorders of connective tissue has considerably advanced our knowledge on this subject. We believe that the range of diseases covered, and the depth in which they were discussed, made this meeting unique. The proceedings contain much original material and reference information which should make them an invaluable addition to the literature on metabolic disorders. The work involved is multi-disciplinary involving among others physicists, organic chemists, biochemists, clinical chemists, paedia­ tricians, physicians, geneticists and neurologists. The bringing together of workers of many disciplines to contribute to the particular subject under discussion at our Symposia has always been an important objective of the Society. In this case we were very fortunate in gathering together experts from all the fields mentioned above. In particular we were honoured that Professor A. Dorfman of Chicago could accept our invitation to give the second Milner Lecture. We were also privileged to have some excellent contributions from the research scientists on whom we must rely for our ultimate understanding of the diseases, and rational approach to treatment.Table of ContentsInborn Errors and Skin.- 1 Inborn errors of skin.- Inborn Errors and Hair.- 2 Inherited conditions affecting the proteins of hair.- 3 Some aspects of the use of hair follicles for the biochiemcal study of inborn errors of metabolism.- Inborn Errors of Connective Tissue.- 4 Morphological aspects of the mucopolysaccharidoses.- 5 Glycosaminoglycans of foetal tissue in two cases of Hurler’s syndrome.- 6 The mucolipidioses: with special reference to I-cell disease.- 7 Structure and biosynthesis of collagen.- 8 Biosynthesis of collagen cross-links : relationship of heritable disorders.- 9 Molecular conformations of connective tissue mucopolysaccharides.- 10 Mucopolysaccharides in ageing.- 11 Genetic aspects of mucopolysaccharidoses with special reference to heterozygous carriers.- The Second Milner Lecture.- 12. Genetic defects of the degradation of glycosaminoglycans: the mucopolysaccharidoses.- 13 Chemistry of dermatan sulphate accumulated intracellularly in Hunter’s disease.- 14 The treatment of genetic mucopolysaccharidoses.- Laboratory Aspects of the Mucopolysaccharides Including diagnosis and screening.- 15 The laboratory diagnosis of the mucopolysaccharidoses.- 16 Screening newborns for mucopolysaccharidoses.- 17 Acid glycosaminoglycan excretion in the mucopolysaccharidoses: determination of glycosaminoglycans in urine and amniotic fluid using new micro-analytical techniques.- 18 An evaluation of methods suitable for a clinical laboratory study of abnormal glycosaminoglycan excretion.

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Book SynopsisIt is a pleasure to present, Nutrition and Exercise in Obesity Management, for reference and textbook use. The text is an outgrowth of the Obesity­ Weight Control Track of the 1982 La Crosse Health and Sports Science Symposium, sponsored annually by the La Crosse Exercise Program, University of Wisconsin-La Crosse. With versatile faculty, topics, and attending professionals, the Obesity-Weight Control Track stimulated an effort to produce interdisciplinary resources on obesity. Out of this effort, three books have been compiled and edited. The first book, Evaluation and Treatment of Obesity, introduces an inter­ disciplinary, practical approach to obesity management. This book, Nutrition and Exercise in Obesity Management, compiles the information specifically related to nutrition and exercise management of obese indi­ viduals. The third book, Behavioral Management of Obesity, relates be­ havioral theories to the modification of eating habits and activity patterns. These three books apply the latest information from the fields of medi­ cine, nutrition, exercise, and psychology to the problem of obesity. The information is intended to guide health professionals in the interdisci­ plinary management of obesity. In 1983 the Obesity-Weight Control Track focused on controversial issues of theoretical and practical concern. The speakers from this track contributed their expertise to the compilation of two additional books. Thus, Trends and Controversies in Obesity Research and Innovation in Obesity Program Development will complete the series. Consider the five volumes a consolidated, comprehensive reference related to the growing, interdisciplinary field of weight control.Table of Contents1. Review of Popular Diets.- 2. Nutritional Management of the Obese Individual.- 3. Protein-Sparing Modified Fasting and Behavior Therapy.- 4. Myths and Misconceptions in Exercise for Weight Control.- 5. Exercise Testing and Training for the Obese.- 6. Exercise Concerns and Precautions for the Obese.

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Book SynopsisThe study of the normal function of the animal and human organisms and of the diseases which disturb that normal func­ tion is largely the study of control mechanisms. These control mechanisms are essential for the survival of an organism in a more or less hostile environment. In many ways they clearly resemble the control mechanisms devised by electronic engin­ eers for running machinery of all kinds and there are many remarkable parallels between biology and engineering. However, it should not be forgotten that the biological systems were on the scene first and that the engineering is a parallel and independent development. It is therefore perhaps a pity that in recent years the study of biological control systems has tended to be dominated by mathematicians and engineers who have moved from these more precise disciplines into biology. As a consequence of this dominance, one often gets the impression that the principles of biological control can be understood only after one has undergone a rather high-powered course in elec­ tronic control theory. It often seems to be assumed that it is electronics which must do all the teaching while biology and medicine must do all the learning. In fact I suspect that biolo­ gical control mechanisms are considerably more sophisticated than anything yet available in the world of the physical sciences and that in the long run biology will teach more to control engineers than vice versa.Table of Contents1 Introduction.- 2 Basic principles of control.- 3 Negative and positive feedback.- 4 The value of disturbance detectors.- 5 The influence of the type of stress on the design of a control system.- 6 Systems with multiple detectors and multiple effectors.- 7 Alteration of the behaviour of control mechanisms.- 8 Implications for research.- 9 Application of control theory to a particular research problem-high arterial pressure.- Further reading.- Appendix-renal hypertension.

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Book SynopsisThe Third Breast Cancer Working Conference of the Breast Cancer Cooperative Group of the European Organization for Research on Treatment of Cancer, to be held in Amsterdam on April 27-29, 1983, was the principle motive for writing this book. It was feh that a short review of the main pathogenetic conceptions and therapeutic principles which have presented themselves with regard to mammary cancer in the Course of Western history , might help to draw a more complete picture of where we stand today. It is not easy to decide which ideas, although discarded, deserve yet to be remembered and which authors from the past may be considered to be truly representative of the scientific climate of their age. Twenty centuries have produced quite a lot of ideas and the number of medical authors who advanced, or rejected, or modified, or revived them, is really uncountable. So the historian has to make a selec­ tion and choices are perforce subjective and open to criticism. In writing this book I tried to consult original sources in the original language as much as possible. These sources were not always strictly medical since I aimed at placing the problem of malignant breast disease - which might serve as a paradigm of cancer in general - in a somewhat wider context. For the history of medicine is not only a history of ideas, but also that of people, of institutions, of society.Table of Contents1. Antiquity.- 2. The Middle Ages.- 3. The Renaissance.- 4. Pathophysiological concepts in the Age of Enlightenment.- 5. Diagnosis and therapy in the eighteenth century.- 6. Europe during Napoleon and after.- 7. Scientific developments in the second half of the nineteenth century.- 8. Mammary carcinoma in the light of new developments.- 9. Surgical treatment in the second half of the nineteenth century.- 10. The twentieth century.- Epilogue.- Notes.- Index of names.

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Book SynopsisThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.Table of ContentsChapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4: Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.

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Book SynopsisFully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.

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Book SynopsisTable of ContentsTop 100 Secrets 1. General Appearance, Facies, and Body Habitus 2. Vital Signs 3. The Skin 4. The Eye 5. The Ear 6. Nose and Mouth 7. The Neck 8. The Thyroid 9. The Breast 10. The Cardiovascular Exam 11. Heart Sounds and Extra Sounds 12. Heart Murmurs 13. Chest Inspection, Palpation, and Percussion 14. Lung Auscultation 15. The Abdomen 16. Male Genitalia, Hernias, and Rectal Exam 17. Female Genitalia and the Pelvis 18. Lymph Nodes 19. The Neurologic System 20. The Musculoskeletal System 21. The Extremities and Peripheral Vascular System

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Book SynopsisAs medical education curricula continue to evolve, many medical schools are implementing programmes which allow students to spend a portion of their time observing primary care physicians in their offices. This is a how-to guide to educating medical students in the patient-care setting.Trade ReviewThe editors are to be applauded for giving us an excellent how-to-manual devoted to this essential aspect of the art of medical education. Journal of the American Board of Family PracticeTable of ContentsForewordPrefaceList of ContributorsPart I: Introduction to Community-Based PreceptingChapter 1. The History and Value of PreceptorshipsChapter 2. How Do I Get Involved in Precepting?Chapter 3. Pitfalls of PreceptingPart II: Characteristics and Needs of LearnersChapter 4. What Medical Students Want and Need From a PreceptorshipChapter 5. Learning Needs of Medical Students Chapter 6. The Teaching MomentPart III: Clinical TeachingChapter 7. Learning During the PreceptorshipChapter 8. Being a Role ModelChapter 9. Integrating the Student Into the Practice Chapter 10. Orienting Medical StudentsChapter 11. Learning ContractsChapter 12. Using Goals and Objectives in Community RotationsChapter 13. SupervisionChapter 14. Teaching and Learning StylesChapter 15. Formative FeedbackChapter 16. Summative Feedback, Evaluation, and Grading StudentsChapter 17. Advising From a Preceptor's PerspectiveChapter 18. Dealing with Learners at Different LevelsChapter 19. Dealing with the Problem LearnerPart IV: Organization of the Preceptorship CurriculumChapter 20. The Ideal PreceptorshipChapter 21. Reinventing the Community-Based PreceptorshipChapter 22. Costs of Precepting and How to DecreaseChapter 23. LogisticsChapter 24. Involving Your Office Staff in TeachingPart V: Relationships to Medical Schools and Other AgenciesChapter 25. Working with Preceptorship Sponsors: Medical Schools and Clinical Departments Chapter 26. Preparing for a Site VisitChapter 27. Working with Local Hospital Administrators Chapter 28. Working with Local Hospital AdministratorsChapter 29. Preceptors in Managed Care OrganizationsPart VI: Legal and Ethical Aspects of PreceptingChapter 30. Liability Issues for PreceptorsChapter 31. Ethics of PreceptingPart VII: Faculty Benefits and ResourcesChapter 32. Support Services and Products Available for Community PreceptorsChapter 33. Electronic Communication for Community PreceptorsChapter 34. Faculty DevelopmentAppendix A. Health Care Financing Administration Rules for Student Documentation in Medicare Patients' ChartsAppendix B. Sample Preceptor-University ContractIndex

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Book SynopsisEnck places great emphasis on enhancing the quality of life while addressing the most common symptoms of terminal illness.Trade ReviewA very well thought out and organized professional book... A thorough book for physicians. -- Carolyn Whitman, M.S., R.N. Inside GCM This Second Edition demonstrates the enormous advances that have been made in the understanding of the treatment of the terminally ill. It provides the clinician with a clear, readable and practical guide to managing clinical problems at the end of life. -- Roger Woodruff International Association for Hospice and Palliative Care Newsletter We can congratulate and thank [Dr. Enck] for adding to the comfort and care of a great many of our fellow human beings as death draws near. Doody's 3-Star ReviewTable of ContentsContents: Preface to the Second Edition List of Abbreviations 1. The Prognostication of Survival Cancer Dementia Motor Neuron Disease Acquired Immunodeficiency Syndrome (AIDS) Central Nervous System Anoxia Advanced Pulmonary Disease Heart Disease Summary I. The Management of Symptoms Common Among Dying Patients 2. General Symtoms of Dying Patients Pain Gastrointestinal Symptoms Nausea and Vomiting Anorexia and Cachexia nutritional Probllmes Hydration Constipation Central Nervous System Symptoms Delirium Depression Systemic Symptoms Dyspnea Urinary Incontinence Pressure Sores Summary 3. Other Problems of Patients with Cancer Malignant Intestinal Obstruction Malignant Dysphagia Neuromuscular Dysfunction Malignant Ulceration Summary 4. Other Problems of Patients with Nonmalignant Diseases Dementia Motor Neuron Disease Acquired Immunodeficiency Syndrom (AIDS) Chronic Vegetative State Advanced Pulmonary Disease Heart Disease Summary 5. Palliative Surgery Principles of Preoperative Care Principles of Operating for Advanced Cancer Principles of Postoperative Care Indications for Surgery Summary II. The Management of Pain 6. An Overview of Pain Management Principles of Pain Management The Ladder Approach Managing the Complications of Pain Treatment Summary 7. Opioids Oral Morphine Parenteral Opioids Alternative Routes of Administration Summary 8. Adjuvant Analgesic Drugs Anticonvulsants Phenothiazines Antidepressants Antihistamines Steroids Antibiotics Amphetamines Butyrophenones Summary 9. Complications of Pharmacologic Therapy Opioids Nonsteroidal Anti-inflammatory Drugs Summary 10. Bone Pain Pathopysiolgoy Radiation Therapy Pharmacotherapy Summary References Index 11. Surgery and Other Nonpharmacologic Interventions to Manage PainSurgery Acupuncture Transcutaneous Electrical Nerve Stimulation Relaxation Techniqu eComplimentary/Alternative Medicine Summary III. The Management of Symptoms During the Last Few Days 12. The Final Moments Terminal Symptoms and Their Managment Drug-Induced Terminal Sedation Summary 13. Issues Concerning the Sustaining of Life Do Not Resuscitate Advance Directives Physician-Assisted Suicide and Euthanasi aSummary References Index

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Book SynopsisThe third edition features a new chapter on recognition, prevention, and remediation of burnout in pediatric oncology staff members, while throughout the book, chapters have been revised and updated to reflect the impact of new antibiotic agents, new antiemetics, and new approaches to pain management.Trade ReviewThe authors have collected very valuable, extensive and up-to-date information on the subjects treated: an ideal reference for all professionals involved in the multidisciplinary care of pediatric cancer patients. -- Susanne Suter European Journal of Pediatrics 2004 This third edition of Supportive Care of Children with Cancer is a highly useful, ready-reference handbook for nurses, medical staff and oncologists involved in paediatric oncology care. Cancer World 2005Table of ContentsForewordPrefaceAbbreviationsList of ContributorsChapter 1. The Prevention of InfectionChapter 2. ImmunizationChapter 3. The Management of Fever and NeutropeniaChapter 4. Blood Component TherapyChapter 5. Hemorrhagic and Thrombotic ComplicationsChapter 6. Hematopoietic Growth FactorsChapter 7. Monitoring and Management of Drug Toxicity Chapter 8. The Management of Drug Extravasation Chapter 9. Side Effects of Radiation TherapyChapter 10. Chemotherapy-Induced Nausea and VomitingChapter 11. The Management of Pain Chapter 12. Oncologic EmergenciesChapter 13. Nutritional SupportChapter 14. Mouth CareChapter 15. Central Venous AccessChapter 16. The Sexually Mature Young Adult Patient With CancerChapter 17. Care of the Hematopoietic Stem Cell Transplant Patient After Leaving the Transplant CenterChapter 18. Psychosocial CareChapter 19. Recognition, Prevention, and Remediation of Burnout in Pediatric Oncology StaffChapter 20. Complementary and Alternative Medicine in Pediatric OncologyChapter 21. Palliative CareIndex

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Book SynopsisNow completely revised and updated! The ultimate guide to taking care of your feet. Written by leading experts with decades of experience in podiatry, this new edition of The Foot Book covers everything you need to know to care for your feet. It addresses the entire foot, inside and out, describing in plain English its anatomy and biomechanical operations. The second edition also: Provides an overview of common and rare foot injuries and syndromes Includes information on alignment and balance problems, heel pain, skin and toe conditions, flat feet, arthritis, and more Offers guidance on medications, exercises, stretches, inserts, therapy, and surgery Explains how to select the right footwear and provides shoe recommendations Covers foot issues in children, athletes, people with diabetes, and people with nerve or vascular problems Includes links to supplemental videos that guide you through stretching, flexibility, and strengthening exercisesIllustrated with nearly 100 images, The FoTable of ContentsPrefacePart I. IntroductionChapter 1. A Guide to the Foot and How We WalkChapter 2. Personal Care and Professional Help for FeetChapter 3. About ShoesPart II. Foot Disorders and Other ProblemsChapter 4. Foot Alignment ProblemsChapter 5. Flat Feet and High-Arched FeetChapter 6. Skin Conditions Affecting the FootChapter 7. Toenail DisordersChapter 8. Bunions and Other Toe Conditions Chapter 9. Heel PainChapter 10. Nerve Syndromes Affecting the Foot and AnkleChapter 11. Arthritis Affecting Foot and Ankle JointsChapter 12. Tendon InjuriesPart III. People with Special Foot NeedsChapter 13. Foot Problems That Start in ChildhoodChapter 14. Common Sports Injuries and the Sports Enthusiast's FootChapter 15. Foot Health for People with DiabetesChapter 16. Orthotic Devices to Alleviate Foot ProblemsChapter 17. Puncture Wounds and Foreign BodiesResourcesIndex

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Book SynopsisThe Pocket Guide to Teaching for Clinical Instructors, 3rd edition, provides a concise introduction to teaching. Written by experienced medical educators from the Advanced Life Support Group and Resuscitation Council (UK), this best-selling guide gives comprehensive and practical advice on the most effective teaching methods. Pocket Guide to Teaching for Clinical Instructors covers basic principles and practical aspects of teaching in a variety of modalities. This edition includes material which reflects current developments within instructor courses and includes new material on feedback, an awareness of non-technical skills, the teaching of teams and supporting learners. This book is essential reading for anyone interested in teaching doctors and healthcare professionals in any context. It is aimed at the relative newcomer to the teaching role in all its variety and provides essential, practical advice as to how to get the best out of learners.Table of ContentsWorking group vii Contributors to the third edition ix Contributors to the first and second editions xi Foreword xiii Preface to the third edition xvii Preface to the first edition xix Acknowledgments xxi 1 Adult learning 1 2 A structured approach to teaching 11 3 Lecturing effectively 15 4 Teaching skills 27 5 Managing simulations 33 6 Facilitating discussions 43 7 Getting assessment right 51 8 Feedback 59 9 e-Learning 69 10 Supporting learning 75 11 Teaching teams 81 Index 85

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Book SynopsisPediatric incontinence: evaluation and clinical management offersurologists practical,''how-to'' clinical guidance towhat is a verycommon problem affecting up to 15% of children aged 6 years old. Introductory chapters cover theneurophysiology, psychological and genetic aspects, as well as theurodynamics of incontinence, before it moves on to itscore focus, namelythe evaluation and management of the problem. All types of management methods will be covered, including behavioural, psychological, medical and surgical, thus providing the reader with a solution to every patient''s specific problem. The outstanding editor team led by Professor Israel Franco, one of the world's leading gurus of pediatric urology, have recruited a truly stellarteam of contributors each of whom haveprovided first-rate, high-quality contributions on theirspecific areas of expertise.Clear management algorithms for each form of treatment support the text, topics of controversyare covereTable of ContentsList of contributors xi Preface xv Section 1: Pathophysiology of bowel and bladder dysfunctionIsrael Franco 1 Neurophysiology of voiding 3Oreoluwa Ogunyemi and Hsi‐Yang Wu 2 Neurophysiology of defecation 15Cecilie Ejerskov and Charlotte Siggaard Rittig 3 Functional brain imaging in bowel and bladder control 21Israel Franco Section 2: Epidemiological aspects of bowel and bladder dysfunctionAlexander von Gontard 4 The epidemiology of childhood incontinence 37Anne J. Wright 5 Quality of life factors in bladder and bowel dysfunction 61Eliane Garcez da Fonseca 6 Psychological aspects in bladder and bowel dysfunction 67Alexander von Gontard 7 Neuropsychiatric disorders and genetic aspects of bowel or bladder dysfunction 73Israel Franco Section 3: Evaluation of bowel and bladder dysfunctionYves Homsy 8 Urodynamics in the pediatric patient 91Beth A. Drzewiecki and Stuart B. Bauer 9 Uroflowmetry and postvoid residual urine tests in incontinent children 99Stephen Shei‐Dei Yang and Shang‐Jen Chang 10 Evaluation of the child with voiding dysfunction 107Yves Homsy 11 Evaluation of constipation and fecal incontinence 121Marc A. Benninga Section 4: Treatments of functional bowel and bladder dysfunctionPaul F. Austin 12 Implementation of urotherapy 133Wendy F. Bower and Janet W. Chase 13 The concept of physiotherapy for childhood BBD 139Janet W. Chase and Wendy F. Bower 14 Biofeedback for the treatment of functional voiding problems 145Ann Raes and Catherine Renson 15 Pharmacotherapy of the child with functional incontinence and retention 153Paul F. Austin and Israel Franco 16 Treatment of functional constipation and fecal incontinence 163Vera Loening‐Baucke and Alexander Swidsinski 17 Peripheral tibial nerve stimulation therapy for the treatment of functional voiding problems 171Mario De Gennaro and Maria Luisa Capitanucci 18 Sacral nerve stimulation therapy for the treatment of functional voiding problems 175Alonso Carrasco Jr, Moira E. Dwyer, and Yuri E. Reinberg 19 Superficial stimulation therapy for the treatment of functional voiding problems 183Ubirajara Barroso, Jr 20 Botulinum toxin in the treatment of the functional bladder 189Luitzen‐Albert Groen and Piet Hoebeke 21 Psychological management of BBD 201Monika Equit and Alexander von Gontard Section 5: Nocturnal enuresisIsrael Franco 22 Pathophysiology of nocturnal enuresis 209Soren Rittig and Konstantinos Kamperis 23 Evaluation of the enuretic child 221Tryggve Neveus 24 Management of monosymptomatic nocturnal enuresis (enuresis) 227Johan Vande Walle 25 Psychological aspects in evaluation and management of nocturnal enuresis (NE) 245Dieter Baeyens and Alexander von Gontard Section 6: Neurogenic bladder and bowel dysfunctionStuart Bauer 26 Diagnostic evaluation in children with neurogenic bladder 257Tom P.V.M. de Jong, Aart J. Klijn, Pieter Dik and Rafal Chrzan 27 Medical management of the neurogenic bladder 263Paul F. Austin and Stuart B. Bauer 28 Treatment of constipation and fecal incontinence: Neuropathic 273Mark P. Cain 29 Neuromodulation for neurogenic bladder in pediatric spinal dysraphism 281Elizabeth B. Yerkes and William E. Kaplan 30 Botulinum toxin in the treatment of neuropathic lower urinary tract dysfunction 293Paul F. Austin and Israel Franco 31 The surgical management of the neurogenic bladder 299Elias Wehbi and Antoine E. Khoury 32 Surgery for bowel dysfunction 309Terry L. Buchmiller 33 Neurological surgery for neurogenic bladder dysfunction 317Michael S. Park and Gerald F. Tuite Index 327

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Book SynopsisThis highly practical book brings the examination of minor neurological dysfunction developed by Bert Touwen and his colleagues in Groningen right up to date, which is timely in view of the increasing interest in and use of this approach. The approach is a detailed and extensive neurological examination with the aim of detecting a possible neurobiological basis for learning, behavioural and motor coordination problems in a child and thus informing decision-making and management. It provides a refined, sensitive and age-appropriate technique, designed to take into account the developmental aspects of the child’s rapidly changing nervous system. This third edition of Bert Touwen’s classic handbook has been updated by Mijna Hadders-Algra to reflect contemporary clinical practice. A new chapter assesses the reliability and validity of the methodology, and the book now includes norms for comparison, as well as practical management guidelines based on current clinical practice. Entirely new photographs and diagrams illustrate the assessment techniques clearly. Videos illustrating typical and atypical performance and an electronic assessment form accompany the book. Contact admin@mackeith.co.uk for access ReadershipPaediatric neurologists, physicians working in neuropaediatrics, developmental paediatrics, child and adolescent psychiatry, and paediatric rehabilitation.Table of ContentsContents Foreword - Professor Bert C L TouwenForeword - Dr Robert Forsyth1. Introduction2. Assessment of minor neurological dysfunction3. Assessment technique and psychometric properties4. Assessment of the Child Sitting - part I5. Assessment of the Child Standing6. Assessment of the child walking7. Assessment of the child lying8. Assessment of the child sitting - part 29. General data10. Interpretation of findings

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Book SynopsisIn this groundbreaking book, Dr. Karen Pape tells the story of how some children with early brain damage astounded everyone around them. The brain injury they suffered at or near birth had led to motor problems such as the awkward gait we associate with cerebral palsy. Yet they were able to run, kick a soccer ball, tap dance, and play tennis. This was not supposed to happen. It ran counter to the prevailing belief that the brain is hardwired and fixed. When Dr. Pape first shared her remarkable findings, she ran into fierce opposition from mainstream medicine. Yet this courageous neonatologist didn't back down. In her clinical practice, Pape helped many young brain-damaged children to significantly improve their movement. It led her to ask why some of them could run but not walk with the same ease. Her answer was astounding: By the time they learned to run, their brains had healed. The awkward walking gait was actually a bad habit acquired while the brain was still damaged. This is the

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Book SynopsisWith its focused review of common cases, high-yield content, and test prep strategies, this book offers the effective preparation available for this high-stakes exam.Table of ContentsSECTION I Introduction 1 1 Primum® CCS Software 2 2 Tips and Strategies 8 3 Reference Sheet 10 4 USMLE Primum® CCS Cases 12 SECTION II CCS Cases by Chief Complaint 27 5 Abdominal Pain 28 6 Fatigue 62 7 Chest Pain 88 8 Altered Mental Status 98 9 Pain in the Extremities 124 10 Cough 138 11 Trauma 154 12 Shortness of Breath 160 13 Back Pain 180 14 Diarrhea 192 15 Headache 204 16 Bruising 216 17 Routine Health Exam 224 18 Miscellaneous Internal Medicine Cases 234 19 Vaginal Bleeding 246 20 Vaginal Discharge 256 21 Miscellaneous Obstetrics/Gynecology Cases 264 22 Pediatric Fever 276 23 Miscellaneous Pediatric Cases 284 APPENDIX CCS Cases Listed by Case Number and Alphabetically by Final Diagnosis 293

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Book SynopsisThis book is a practical resource for physiotherapists and occupational therapists who support people with cerebral palsy, helping them to solve the problems with movement and other impairments that so often accompany cerebral palsy, so that they can be more active and better able to participate in roles such as study, work, recreation and relationships. The first chapters provide the background to the clinical reasoning approach that informs the whole text, as well as an overview of therapeutic interventions. The subsequent chapters present clinical situations that therapists will encounter in the course of their work with individuals with cerebral palsy across the lifespan. Each chapter describes a case in detail, including the reasoning behind assessment and treatment choices, interventions and outcomes. The themes emphasized throughout the book are the use of the clinical reasoning approach of the intervention process model, the International Classification of Functioning, Disability and Health as a framework to help therapists inform patient and family decision-making, family-centred approaches in developing and implementing therapeutic strategies, and multidisciplinary team work.Trade Review "Physiotherapy and Occupational Therapy for People With Cerebral Palsy is an excellent reference for physicians. For primary care clinicians, it presents a comprehensive overview of concerns, goals, and therapies throughout the life span. This is particularly useful for pediatricians as they support and guide parents through the period of diagnosis and provide referrals for specialized evaluations and services. Physician specialists in cerebral palsy, particularly orthopedists, should find this book an excellent resource when prescribing an unfamiliar therapeutic intervention. In addition, the appendix, "Assessment of the Individual With Cerebral Palsy," explains the purpose, validity, reliability, responsiveness, and clinical utility of common measurements used by therapists that should prove helpful when interpreting therapy progress notes." (JAMA, February 2011) Table of ContentsFOREWORD (Peter Rosenbaum). PART 1: BACKGROUND: KEY ISSUES IN PLANNING THERAPY FOR PEOPLE WITH CEREBRAL PALSY. 1. INTRODUCTION TO THE CLINICAL REASONING APPROACH OF THE BOOK (Christine Imms, Karen J. Dodd, and Nicholas F. Taylor). 2. WHAT IS CEREBRAL PALSY? (Christine Imms and Karen J. Dodd). 3. UNDERSTANDING THE FAMILY’S PERSPECTIVE: PARENTING A CHILD WITH CEREBRAL PALSY (Helen Bourke-Taylor). 4. OVERVIEW OF THERAPY (Karen J. Dodd, Christine Imms and Nicholas F. Taylor). PART 2: THE PRE-SCHOOL YEARS. IN THE BEGINNING. 5. THE INFANT WITH COMPLEX NEEDS (Sarah Foley and Susan Greaves). BEING TWO. 6. EARLY STEPS (Karen J. Dodd and Sue Greaves). 7. MODIFIED CONSTRAINT-INDUCED THERAPY FOR YOUNG CHILDREN (Margaret Wallen and Christine Imms). GETTING READY FOR SCHOOL. 8. GOAL-DIRECTED TRAINING OF ACTIVITY PERFORMANCE (Brian Hoare and Christine Imms). 9. THE ROLE OF BOTULINUM TOXIN A INJECTIONS IN THE LOWER EXTREMITY (Pam Thomason and H. Kerr Graham). PART 3: THE SCHOOL YEARS. GETTING THINGS STRAIGHT. 10. PHYSIOTHERAPY FOLLOWING SINGLE-EVENT MULTILEVEL SURGERY (SEMLS) (Adrienne Harvey). 11. OCCUPATIONAL THERAPY FOLLOWING UPPER-EXTREMITY SURGERY (Josie Duncan). TRANSITION TO SECONDARY SCHOOL. 12. NAVIGATING SCHOOL-BASED NEEDS AND TECHNOLOGICAL SUPPORTS FOR SECONDARY SCHOOL (Margaret Mayston). DOING IT YOURSELF. 13. STRENGTH TRAINING FOR ADOLESCENTS (Nicholas Taylor and Karen J. Dodd). PART 4: ADULTHOOD. GETTING OUT THERE. 14. TRANSITIONS TO ADULTDHOOD (Mary Law and Debra Stewart). COMMUNITY ACCESS. 15. THE YOUNG ADULT WITH COMPLEX DISABILITY (Barbara Scoullar and Christine Imms).

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Book SynopsisClear and concise, The Only Neurology Book You'll Ever Need provides a straightforward and comprehensive overview of neurology. It covers all of the important neurologic diagnosis and management issues, along with clinically relevant anatomy and physiology. Written by Drs. Alison I. Thaler and Malcolm S. Thaler, this new title is packed with full-color illustrations, real-world clinical scenarios, and up-to-date guidelines and recommendations —giving you all the practical advice you need to master the challenging world of neurology. Features a lighthearted, lively writing style that is compelling and gets right to the heart of what you need to know. Discusses the elements of the neurologic exam and what symptoms do and don’t suggest a neurologic disorder. Covers key topics such as stroke, headache, concussion, dizziness, seizures, dementia, meningitis, multiple sclerosis, Parkinson disease, and much more. Abundant illustrations, charts, and tables, help you easily understand and retain complex material. Ideal for medical students, medicine and neurology residents, nurses, and PAs, as well as any and all practitioners who need a concise, easy-to-read review of clinically- relevant neurology. This book covers everything you need for the medical student shelf exam in neurology. Enrich Your eBook Reading Experience Read directly on your preferred device(s), including computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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Book SynopsisTable of ContentsColor Plate Section follows the Front Matter 1 Cardiovascular System 2 Pulmonary System 3 Gastroenterology System 4 Musculoskeletal System 5 Endocrine System 6 Eyes, Ears, Nose, and Throat System 7 Neurologic System 8 Reproductive System 9 Infectious Disease 10 Psychiatry/Behavioral Science 11 Dermatologic System 12 Hematologic System 13 Genitourinary and Renal Systems 14 Pediatrics 15 Pharmacology 16 Laboratory Medicine 17 Professional Issues 18 Test-Taking Strategies Appendices 1 Adult Preventive Health Guidelines 2 U.S. Preventive Services Task Force Screening Guidelines for Common Diseases 3 Cranial Nerves and Function 4 Common Signs in Medicine 5 Poisoning Antidotes 6 Normal Laboratory Values Index

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Book SynopsisThis practical, thorough, and concise pocketbook is the perfect companion to the clinical skills needed for life on the wards. It covers all the essential elements that lie at the heart of medical practice in which students must prove their competence, and lays the foundations needed for the rest of their medical career. Part One covers history taking, examination and communication; and Part Two provides an overview of key practical procedures and diagnostic skills, all of which are typically examined via Objective Structured Clinical Examinations (OSCEs) or other clinical case format examinations. The coverage of examination skills alongside practical procedures and explanations of typical tests and investigations make this pocketbook invaluable for students new to clinical medicine. The authors are specialists in teaching clinical skills from both a medical and surgical perspective, and are perfectly placed to cover these cornerstones of medical practice.Trade ReviewPublished Reviews "Lecture Notes on Clinical Skills fits into both white coat and book budget, something the first year clinical student should bear in mind." GKT Gazette "It is a little smasher." Surgo, Glasgow University Medical School "An excellent reference for students and junior doctors on hospital clinical placements." Scottish Medical Journal "A very practical, 'white coat' text." Pediatric Endocrinology ReviewsTable of ContentsSection I: History and examination Chapter 1 History taking 3 Chapter 2 General examination 25 Chapter 3 Examination of the cardiovascular system 59 Chapter 4 Examination of the chest 87 Chapter 5 Examination of the abdomen 97 Chapter 6 Examination of the mental state 112 Chapter 7 Examination of the nervous system 122 Chapter 8 Assessment of disability including care of the elderly 166 Chapter 9 Basic examination, notes and diagnostic principles 173 Chapter 10 Presenting cases and communication 185 Section II: Clinical investigation and practical skills Chapter 11 Clinical and radiological investigations 201 Chapter 12 Endoscopy 230 Chapter 13 Cardiological investigations 236 Chapter 14 Practical skills 279 Chapter 15 Common emergency treatments 326 Appendices Appendix 1 Jaeger reading chart 338 Appendix 2 Visual acuity 3 m chart 338 Appendix 3 Cardiac arrest instructions 340 Appendix 4 Duties of a doctor 341 Appendix 5 Laboratory results—normal values 342 Appendix 6 Examples of OSCE assessment stations 349 Appendix 7 Rockall Score 350 Index 351

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Book SynopsisThe gynecology of young girls and teenagers provides exacting challenges. Intimate examination can be daunting for the patient, and the balance between parental permission and patient privacy shifts as menstruation and sexual activity begins.Table of ContentsPreface, xi Contributors, xiii SECTION 1 PREPUBERTAL GIRLS, 1 Part 1 Introduction 1 Initial assessment, 3 Maureen Lynch Part 2 Prepubertal Girls: Symptoms and Signs 2 Ambiguous genitalia in the neonate and infant, 6 Sejal Shah and Avni C. Shah 3 Vaginal discharge and odor, 14 Corinne Bazella and Majorie Greenfield 4 Vaginal bleeding, 18 Valerie S. Ratts 5 Ovarian masses, 22 Julie L. Strickland and Anne-Marie Priebe Part 3 Prepubertal Girls: Gynecologic Conditions 6 Labial adhesions, 29 Jane E. D. Broecker 7 Pediatric vulvovaginitis, 33 Sari Kives 8 Sexual abuse, 38 Nancy D. Kellogg and James L. Lukefahr SECTION 2 CONCERNS IN PREPUBERTAL GIRLS AND IN ADOLESCENTS, 43 Part 1 External Genitalia 9 Normal hymen and hymenal variations, 45 Amy D. DiVasta and Estherann Grace 10 Vulvar signs and symptoms, 49 10.1 Overview of vulvar signs and symptoms, 49 Paula J. Adams Hillard 10.2 Vulvar ulcers and aphthosis, 57 Helen R. Deitch 10.3 Vulvar tumors, cysts, and masses, 60 Meredith Loveless 10.4 Vulvar abscesses, 64 Jennie Yoost and S. Paige Hertweck 11 Vulvar lichen sclerosus, 69 Paula J. Adams Hillard 12 Accidental trauma, 72 Mariel A. Focseneanu and Diane F. Merritt 13 Female genital mutilation, 76 Katherine A. Zakhour and Comfort Momoh Part 2 Puberty 14 Normal puberty, 80 Jennifer C. Kelley and Frank M. Biro 15 Precocious puberty, 87 Paul B. Kaplowitz 16 Delayed puberty, 91 Sara E. Watson, Peter A. Lee and Christopher P. Houk SECTION 3 ADOLESCENT GIRLS, 97 Part 1 Adolescent Health 17 Initial assessment: consultation with an adolescent girl, 99 Paula J. Adams Hillard 18 Confidentiality, 103 Janice Bacon and Jennifer A. Greene 19 Legal issues, 108 Rebecca Gudeman and Abigail English 20 Adolescent sexuality, 114 Linda M. Kollar 21 Adolescent preventive care for healthy teens, 119 Kristin L. Kaltenstadler and Corinne Lehmann 22 Weight, 125 22.1 Overweight and obesity and gynecologic conditions, 125 Stephanie Crewe and Maria Trent 22.2 Eating disorders, 131 Anne Hsii and Neville H. Golden 23 The female athlete, 138 James R. Ebert 24 Immunizations, 142 Amy B. Middleman 25 Substance abuse: screening and brief intervention, 146 Patricia Schram and Sharon Levy 26 Suicidal ideation and self-harm: screening, 151 Matthew B. Wintersteen and Christopher V. Chambers 27 Healthcare for lesbian, bisexual, and transgender adolescents, 154 Elizabeth B. Erbaugh and Margaret J. Blythe 28 Developmental delay, 158 Lisa Allen and Melanie Ornstein 29 Menstrual health, 163 29.1 Tampons and menstrual hygiene products, 163 Stephanie Stockburger and Hatim A. Omar 29.2 Normal menses, 166 Paula J. Adams Hillard 29.3 Menstrual suppression, 169 Kelly Kantartzis and Gina Sucato 30 The gynecologic exam, 174 30.1 When and how to perform a gynecologic exam, 174 Paula J. Adams Hillard 30.2 Cervical cytology screening, 180 Paula J. Adams Hillard 31 Sexually-transmitted disease screening, 183 Michael G. Spigarelli Part 2 Pregnancy Prevention and Options 32 Unintended pregnancy: options and counseling, 187 Kaiyti Duffy and Rachael Phelps 33 Contraceptive counseling, 192 33.1 Contraceptive counseling for healthy teens, 192 Stephanie B. Teal 33.2 Contraceptive counseling for teens with medical illness, 197 Melissa Gilliam and Amy Whitaker 34 Contraception, 205 34.1 Barrier methods, 205 Uri Belkind and Susan M. Coupey 34.2 Oral contraception, 210 Emily M. Godfrey and Melissa Kottke 34.3 Transdermal and vaginal combination methods, 217 Sherine Patterson-Rose and Paula Braverman 34.4 Intrauterine devices, 222 Sophia Yen 34.5 Progestin-only contraception, 226 Michelle M. Isley and Andrew M. Kaunitz 34.6 Emergency contraception, 230 Kaiyti Duffy and Melanie A. Gold Part 3 Adolescent Girls: Symptoms and Signs 35 Hirsutism, 234 Dianne Deplewski and Robert L. Rosenfield 36 The breast, 241 36.1 Breast concerns, 241 Kaylene J. Logan and Eduardo Lara-Torre 36.2 Breast discharge, 246 Donald E. Greydanus and Colleen Bryzik Dodich 37 Vaginal discharge, 249 Seema Menon, Mandakini Sadhir, and Susan Jay 38 Pelvic masses, 254 Noam Smorgick-Rosenbaum and Elisabeth H. Quint 39 Gynecologic pain, 260 39.1 Pelvic and abdominal pain, 260 Geri D. Hewitt 39.2 Myofascial (musculoskeletal) pain, 266 John Jarrell 40 Amenorrhea, 269 Melanie Nathan and Andrea L. Zuckerman 41 Abnormal uterine bleeding, 275 Jennifer E. Dietrich and Jennifer L. Bercaw-Pratt 42 Premenstrual syndrome/premenstrual dysphoric disorder and mood disorders, 281 Michael Dobbs and Paula Braverman Part 4 Adolescent Girls: Gynecologic Conditions 43 Vulvovaginal conditions, 285 43.1 Yeast/candida, 285 Sofya Maslyanskaya and Elizabeth Alderman 43.2 Bacterial vaginosis, 289 Jennifer Louis-Jacques and Rebecca Flynn O’Brien 44 Sexually-transmitted diseases, 293 44.1 Genital herpes, 293 Terri Warren 44.2 Human papillomavirus and condyloma, 297 Lea E. Widdice and Jessica A. Kahn 44.3 Chlamydia, 302 Taraneh Shafii and Gale R. Burstein 44.4 Gonorrhea, 307 Bree Weaver and J. Dennis Fortenberry 44.5 Trichomonas, 312 Samantha E. Montgomery and Jill S. Huppert 44.6 HIV, 315 Anita Radix and Donna Futterman 44.7 Other sexually-transmitted diseases, 318 Ellen S. Rome 45 Dysmenorrhea, 325 Michelle Forcier and Zeev Harel 46 Congenital anomalies, 330 Amy M. Vallerie and Lesley L. Breech 47 Ectopic pregnancy, 339 Michelle Vichnin 48 The ovaries, 342 48.1 Ovarian cysts, 342 Paula J. Adams Hillard 48.2 Ovarian germ cell tumors, 348 Claire Templeman 49 Endometriosis, 351 Mary Anne Jamieson 50 Polycystic ovary syndrome, 355 Samantha M. Pfeifer 51 Pelvic infl ammatory disease, 361 Colleen McNicholas and Jeffrey F. Peipert 52 Gonadal dysgenesis, 366 Courtney A. Marsh and Yolanda R. Smith 53 Sexual assault and date rape, 371 Beth L. Emerson and Kirsten Bechtel Appendix 1 Essential information, 375 Appendix 2 Useful web resources for adolescents, their parents/caregivers, and clinicians, 389 Index, 391

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Book SynopsisThe chapters in this monograph detail the past, present and potential future of markers used for the detection of myocardial injury and for risk assessment as part of a cardiovascular disease work-up strategy.Table of ContentsChapter 1. Analytical Issues Affecting the Clinical Performance of Cardiac Troponin Assays - Alan H.B. Wu, PhD. Chapter 2. Prepare To Meet Your Markers: Making the Most out of Troponin I Degradation - Jason L. McDonough, BSc(H), Ralf Labugger, MSc, and Jennifer E. Van Eyk, PhD. Chapter 3. Functional Sensitivity of Cardiac Troponin Assays and its Implications for Risk-Stratification for Patients with Acute Coronary Syndromes - Kiang-Teck J. Yeo, PhD, Kelly S. Quinn-Hall, MT, Stephanie W. Bateman, BA, George A. Fischer, PhD, Stacey Wieczorek, PhD, and Alan H.B. Wu, PhD. . Chapter 4. Report on a Survey of Analytical and Clinical Characteristics of Commercial Cardiac Troponin Assays - Fred S. Apple, PhD, Jesse E. Adams III, MD, Alan H.B. Wu, PhD, and Allan S. Jaffe, MD. Chapter 5. The Current Assessment of Qualitative and Quantitative Point-of-Care Testing of Cardiac Markers - Roland Valdes, Jr, PhD and Saeed A. Jortani, PhD. Chapter 6. Acute Coronary Syndromes: Pathophysiology, Clinical Presentation, and Initial Diagnostic Strategies - Jesse E. Adams III, MD and Vickie A. Miracle, RN, EdD. Chapter 7. WHO Criteria: Where Do We Go from Here? - Allan S. Jaffe, MD. Chapter 8. An Integrated Diagnostic Approach to the Patient with Chest Pain - Robert L. Jesse, MD, PhD and Michael C. Kontos, MD. Chapter 9. The Use of Cardiac Markers for Therapeutic Decisions in Acute Coronary Syndromes - Michael P. Hudson, MD, Britta U. Goldmann, MD, E. Magnus Ohman, MD. Chapter 10. The Evaluation of Acute Coronary Syndrome in the Emergency Department: The Impact of Cardiac Biomarkers and ST-Segment Trend Monitoring - David A. Grundy, MD and W. Brian Gibler, MD. Chapter 11. Cardiac Troponin T in Coronary Artery Disease: Where Do We Stand? Evangelos Giannitsis, MD, Britta Weidtmann, MD, Margit Müller-Bardorff, MD, Norbert Frey, MD, and Hugo A. Katus, MD. Chapter 12. Creatine Kinase: A Marker for the Early Diagnosis of Acute Myocardial Infarction - Robert Fromm, MD, MPH and Robert Roberts, MD. Chapter 13. Fatty Acid Binding Protein as a Plasma Marker for the Early Assessment of Individuals with Acute Coronary Syndromes - Jan F.C. Glatz, PhD and Wim T. Hermens, PhD. Chapter 14. Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein: Markers of Coronary Artery Disease - Paul Holvoet, PhD, Frans Van de Werf, MD, PhD, Johan Vanhaecke, MD, PhD, and Désiré Collen, MD, PhD. Chapter 15. High-Sensitivity C-Reactive Protein: A Novel Inflammatory Marker for Predicting the Risk of Coronary Artery Disease - Paul M. Ridker, MD, MPH. Chapter 16. Nuclear Factor Kappa B: A Marker of Coronary Artery Disease Activity? - George K. Daniel, MD, Richa Gupta, MD, Jessica Gillespie, BS, Rose Felten, BS, Linda Cise, MS, Kathy Sturdevant, BS, and Michael E. Ritchie, MD. Chapter 17. The Use of Troponins to Detect Cardiac Injury after Cardiac and Noncardiac Surgery - Jesse E. Adams III, MD. Chapter 18. The Role of Cardiac Troponin Testing in Renal Disease - Fred S. Apple, PhD. . Chapter 19. The Use of Cardiac Biomarkers for the Detection of Drug-Induced Myocardial Damage - Eugene H. Herman, PhD and V.J. Ferrans, MD, PhD. Chapter 20. The Utility of Brain Natriuretic Peptides in Patients with Heart Failure and Coronary Artery Disease - Johannes Mair, MD

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Book SynopsisMassage is a basic skill within physiotherapy, and one which requires a high standard of practical application. It is a skill which is increasingly being taken up by other health care and complementary therapy professionals. This new, third edition of Massage for Therapists is a timely and thorough update which continues the tradition of Margaret Hollis'' hands-on approach. The book is designed to be a step-by-step guide to the theory and practical application of classical massage. Once mastered, these techniques may form the basis for a variety of modifications suitable for specific conditions. Massage for Therapists is split into three sections: an introduction to massage and preparation for giving a massage; the massage manipulations by area of the body; and some key modifications to the standard manipulations. In order to further enhance the practitioner''s skill and to give the reader a grounding in some of the popular specialities, updated chapters on aroTrade Review"This book would be a invaluable reference for any physical therapist wanting both consolidation and increased depth of knowledge of massage techniques. Some sections of the book will be of particular use to undergraduate students, postgraduate students and professionals, as they describe the theoretical underpinning and clinical reasoning for massage therapy. I recommend that physical therapists who work in clinical settings, hospitals, institutions and the other rehabilitation centres should read this book in order to enhance their clinical skills and to augment the efficacy of their treatments." (International Journal of Therapy and Rehabilitation, October 2010) Table of ContentsTrigger points. Nerve impingement. The nervous system. The CNS. The PNS. Basic structure of the nervous system. The neuro-endocrine mechanism. Entrainment. The circulatory system. The cardiovascular system. Function. Structure. Blood pressure. The lymphatic system. Function. Structure. The cerebrospinal fluid system. Function. Structure. Fluid balances. The endocrine/hormonal system. (ductless glands). Function. Structure. The effects of stress on the endocrine system. The respiratory system. Function. Structure. External respiration. Internal respiration. Nervous and chemical control.of respiration. The digestive system. Function. Structure. The energy system. Foreword. Preface. Contributors. Acknowledgements. I The basis for massage. 1 Introduction to massage. (Elisabeth Jones) Western forms of massage. Eastern forms of massage. Globalisation. 2 Relevant anatomy and physiology: an overview. (Elisabeth Jones) The skin. Function. Structure. Appendages of the skin. Connective tissues. Piezo-electricity. Fluid balances of the skin. The musculoskeletal system. The skeleton. Function. Muscles. Function. Structure. Definitions associated with muscle action. Reflexes. Common terms. Anatomical position. Common terms. 3 Evidence-based effects, risk awareness and contraindications for massage. (Dr David Lee and Carol Young) Mechanical effects. Physiological effects. Physiological effects on the.circulatory system. Physiological effects on the nervous system. Alpha motoneuron excitability. Pain. Physiological effects on the musculoskeletal system. Psychological effects. Summary of the mechanisms of massage therapy. Massage in vulnerable groups – risk awareness and contraindications. Contraindications for massage therapy. II The application of massage. 4 Examination and assessment. (Ann Thomson) Treatment planning. Examination of patients. Assessing findings. Clinical reasoning. Clinical features that may guide the therapist towards the possible sources/causes of patients problems (the ‘genics’). Determining the indications for massage. Aspects of examination and assessment that relate to massage. Observation and palpation using massage strokes to identify indications. Observation and palpation using massage strokes to identify contraindications. Measuring change and outcome measures. Examination and assessment recording. Palpation and skill. Specific soft tissue mobilisations (SSTMs). 5 Preparation for massage. (Margaret Hollis and Elisabeth Jones) Self preparation. Hand exercises. Relaxation. The environment. Contact mediums. Powder. Oils. Liquid oils. Creams. Water-based lubricants. Soap and water. Allergic reactions. Preparation of the patient. Palpation and developing sensory awareness. Examination of the part . Ticklish subjects. 6 Massage manipulations. (Margaret Hollis and Elisabeth Jones) Effleurage. Stroking. Petrissage. Kneading. Picking up. Wringing. Rolling. Muscle shaking. Frictions. Circular frictions. Transverse frictions. Tapôtement (percussion). Hacking. Clapping. Vibrations. Beating. Pounding. Tapping. 7 Massage to the upper limb. (Margaret Hollis and Elisabeth Jones) Preparation of the patient. For a treatment in sitting position. * From the chapter by Janice M. Warriner and the late Alison M. Walker in the second edition of this book (Hollis 1998). For a treatment in lying position. To elevate the arm. Effleurage. To the whole limb. Part strokes. Kneading. Double-handed alternate kneading. Single-handed kneading. Finger kneading. Thumb kneading. Picking up. Wringing. Muscle shaking. Muscle rolling. Hacking and clapping. 8 Massage to the lower limb. (Margaret Hollis and Elisabeth Jones) Preparation of the patient. Preparation of the treatment couch. Treatment of the lower limb with the patient supine. Treatment of the lower limb with the patient prone. Effleurage. To the whole limb. Part strokes. Kneading. The thigh. Round the knee. Thumb kneading round the patella. Finger kneading the knee. The calf muscles. Palmar kneading the anterior tibial muscles. Palmar kneading the peronei. The foot. Thumb kneading the anterior tibial muscles. Thumb kneading the peronea muscles. Thumb kneading the dorsum of the foot. Thumb kneading the sole of the foot. Thumb kneading the interosseous spaces. Thumb and finger kneading the toes. Picking up. The thigh. The calf. Wringing. The thigh. The calf. Muscle shaking. The thigh. The calf. Skin rolling and skin wringing. The knee. Hacking and clapping. The thigh. The calf. The anterior tibial and peroneal muscles. 9 Massage to the back, gluteal region and neck.(Margaret Hollis and Elisabeth Jones) The thoracolumbar region. Preparation of the patient. Preparation of the treatment couch. Treatment of the patient in prone lying. Effleurage. Kneading. Alternate, double-handed kneading. Single-handed kneading. Superimposed kneading. Thumb kneading. Finger kneading. Skin rolling. Wringing. Muscle rolling. Hacking and clapping. The gluteal region. Preparation of the patient. Effleurage. Kneading. Superimposed kneading. Frictions. Circular frictions. Picking up. Wringing. Hacking and clapping. The neck. Client in prone lying. Client in lying. Client in side lying. Client in forward lean sitting. Effleurage. Kneading. Picking up. Muscle rolling. Hacking and clapping. 10 Massage to the face and scalp. (Margaret Hollis and Elisabeth Jones) Preparation of the patient. Face massage. Effleurage. Kneading. Wringing. Plucking. Tapping. Vibrations. Exit foramina of the trigeminal nerve. Over the sinuses. Muscle stretching. Occipitofrontalis. Clapping. To the platysma. Scalp massage. Effleurage/stroking. Kneading. Vibrations. 11 Massage to the abdomen. (Margaret Hollis and Elisabeth Jones) Preparation of the patient. Palpation. Effleurage. Kneading. Vibrations. Brisk lift stroking and shaking. Stroking. The ascending colon. The transverse colon. The descending colon. Kneading. The ascending colon. The descending colon. Rolling. Skin wringing. Points to be observed. 12 Uses of classical massage in some health care settings: an overview. (Elisabeth Jones) Stress. Depression. Anxiety. Occupational situations. Pre natal, labour and post natal. Babies. Children. The older population. Learning disabilities. Mental health. Physical disabilities. Neuromuscular-skeletal conditions. Neurological conditions. Cancer care. Contraindications/precautions. HIV/AIDS. Pain. Respiratory conditions. Reconstructive surgery. Scar management. Desensitisation. Oedema management. III Some specialised techniques. 13 Some types of massage and soft tissue therapies (Elisabeth Jones) Active release technique (ART). Acupressure. Animal massage. Aromatherapy. Ayurvedic massage. Bio-energy therapies. Bowen therapy. Classical massage. Connective tissue manipulation (CTM). Craniosacral therapy. Heller work. Indian head massage. Lomi lomi. Manual lymph drainage (MLD). Muscle energy technique (MET). Myofascial release (MFR). Neuromuscular therapy. Periosteal massage. Pin and stretch. Polarity therapy. Positional release. Proprioceptive neuromuscular facilitation (PNF). Hold relax (HR) (contract relax. Auto hold relax. Repeated contractions (RC). Combining repeated contractions with soft tissue techniques. Slow reversals (SR). Stabilisations. Reflexology. Rolfing (structural integration). Segment massage. Shiatsu. Soft tissue release (STR). Specific soft tissue mobilisations (SSTMs). Specific stretch. Sports massage. Swedish massage. Thai massage (Thai yoga massage). Therapeutic touch. Trager. Transcadence massage. Trigger point release. Tuina/tui na (pronounced tweena). Vibrational therapy (VT). Zero balancing. 14 Massage in sport. (Joan M. Watt) Basic rules of sports massage. Diagnosis. History. Contraindications. Aims of treatment. Position. Materials. Skin preparation. Joint position. Technique. Check with the participant. Clean up. Warn the participant. Massage manipulations in sports massage. Acupressure. Trigger pointing. Ice massage. Specific sports massage. Massage in conditioning. Massage as a treatment. Pre-competition massage. Inter-competition massage. Post-competition massage. Post-travel massage. Non-specific sports massage. General body massage. Specific areas of massage. Summary. Case study. 15 Aromatherapy. (Elisabeth Jones) Introduction. Historical uses of essential oils. Egyptians: 3000–1500 BC. Greeks: 500–40 BC. Europeans. Essential oils. Basic chemistry. Mind and body. Extraction methods. A working knowledge of essential oils. Methods of administering essential oils. Olfaction. Inhalation. Skin absorption. Ingestion. Glossary of terms and properties of some essential oils. The practical application of essential oils. Olfaction/inhalation. Skin absorption. Ingestion. The holistic approach. Aromatherapy massage. Lymphatic drainage. Neuromuscular massage. Acupressure. Effects and uses of aromatherapy massage. Muscle tension. Blood circulation. Pain. Fatigue. Infection. Relaxation. One-to-one care. Support for staff and carers. Sleep. General wellbeing. Pregnancy/childbirth/baby care. The elderly. Consultation procedures. Verbal. Visual. Tactile. Personality type. Other information. Oils. Contraindications. Hazards. Oils not to be used at all in therapy. Oils never to be used on the skin. Oils not to be used with patients who have epilepsy. Pregnancy. Precautions. Blending of oils and formulation. Basic formula. Preparation of the patient. Treatment by aromatherapy massage. Case study. Purity of essential oils. Storage. Conclusion. 16 Shiatsu – the Japanese healing art of touch. (Andrea Battermann) Introduction. What is shiatsu? History. Introduction to oriental medicine. Diagnostic methods. Four forms of diagnosis. Shiatsu theory. Basic principles and techniques of shiatsu. Clinical indications. Contraindications. Cautions. Physiological effects associated with shiatsu. Case study: self-shiatsu massage. The self-shiatsu routine. How to apply pressure. Professional development of the therapist. Conclusions. Glossary. 17 Myofascial release and beyond. (Ann Childs and Stuart Robinson) Introduction to the fascial matrix. Aims of the MFR approach. Palpation philosophy and possible barriers to effectiveness. Exercises to enhance palpatory skills. Exercise 1: Attuning whole and bilateral hand sensitivity. Exercise 2: Enhancing palpatory sensitivity. Exercise 3: Palpating fascial glide. Exercise 4: Influence of palpation and body tension. Exercise 5: Palpation changes with different states of mind. Exercise 6: Identifi cation and documentation of fascial restrictions. Exercise 7: Identification of the dominant holding pattern in the body. Myofascial release techniques. A sustained stretch technique. Contraindications. Beyond the anatomy. Involving the mind and feelings. An exploration of suggested rationale and their clinical implications. Responsive biomechanical model. Neural-mechanoreceptor model. Gel-to-sol model. Piezo-electric model. Trauma release model. Evidence of effectiveness in clinical practice. So what do we feel with our hands? Future implications. Index.

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Book SynopsisThis brand new Lecture Notes title provides the core biomedical science study and revision material that medical students need to know. Matching the common systems-based approach taken by the majority of medical schools, it provides concise, student-led content that is rooted in clinical relevance. The book is filled with learning features such as key definitions and key conditions, and is cross-referenced to develop interdisciplinary awareness. Although designed predominantly for medical students, this new Lecture Notes book is also useful for students of dentistry, pharmacology and nursing. Biomedical Science Lecture Notes provides: A brand new title in the award-winning Lecture Notes series A concise, full colour study and revision guide A ''one-stop-shop'' for the biomedical sciences Clinical relevance and cross referencing to develop interdisciplinary skills Learning features such as key definiTrade Review"Each chapter moves concisely through the appropriate science, highlighting its relevance to clinical practice. The information is well presented and easy to navigate." (Oxford Medical School Gazette, 2011)Table of ContentsPreface. Acknowledgements. Abbreviations. 1 Cell biology. 2 Molecular biology and genetics. 3 Biochemistry. 4 Physiology. 5 Pharmacology. 6 Cardiovascular system. 7 Respiratory system. 8 Gastrointestinal system. 9 Urinary system. 10 Endocrinology. 11 Integrative physiology. 12 Reproduction. 13 Embryology. 14 Anatomy/musculoskeletal system. 15 Immunology. 16 Microbiology. 17 Neuroscience. 18 Medical statistics. Index.

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Book SynopsisTable of ContentsContributors ix Preface xi Acknowledgements xiii About the Companion Website xv Chapter 1 How to Use This Book 1 Introduction 1 Common indications 2 Basic anatomy 2 Equipment 2 Patient positioning 5 Slice prescription 6 Suggested protocol 6 Protocol optimization 6 Patient considerations 6 Contrast usage 6 Summary 7 Terms and abbreviations used in Part 2 7 Conclusion 17 Part 1 Theoretical and Practical Concepts 19 Chapter 2 Protocol Parameters and Trade-offs 21 Introduction 21 Signal-to-noise ratio (SNR) 24 Contrast-to-noise ratio (CNR) 24 Spatial resolution 25 Scan time 26 Decision strategies 27 Conclusion 28 Chapter 3 Pulse Sequences 29 Introduction 29 Conventional spin echo (CSE) 29 Fast spin echo or turbo spin echo (FSE/TSE) 32 Inversion recovery (IR/FSE/TSE-IR) 34 Rewound gradient echo 35 Balanced GRE 35 Spoiled GRE 36 Reverse echo GRE 37 Echo planar imaging (EPI) 38 Conclusion 42 Chapter 4 Flow Phenomena and Artefacts 44 Flow phenomena 44 Introduction 44 Time of flight (TOF) 45 Entry slice phenomenon 46 Intra-voxel dephasing 46 Flow artefact remedies 46 Artefacts 48 Introduction 48 Phase mismapping 48 Aliasing 48 Chemical shift 49 Out-of-phase signal cancellation 49 Truncation 49 Magnetic susceptibility 49 Magic angle 50 Conclusion 51 Chapter 5 Gating and Respiratory Compensation Techniques 53 Introduction 53 Cardiac gating (ECG/EKG gating) 53 Peripheral gating (Pe gating) 58 Ciné imaging 59 Imaging planes 60 Respiratory Compensation (RC) 60 Conclusion 61 Chapter 6 Patient Care and Safety 62 Introduction 62 Patient screening 62 Safety zones 63 Safety concerns during the examination 64 Patient counselling 65 Patient immobilization 67 Patient after-care 67 Conclusion 67 Chapter 7 Contrast Agents 68 Introduction 68 Gd-based positive contrast agents 68 Negative contrast agents 70 Patient considerations 70 Conclusion 70 Part 2 Examination Areas 71 Chapter 8 Head and Neck 73 Brain 73 Temporal lobes 86 Internal auditory meatus and posterior fossa 92 Pituitary fossa 97 Orbits 102 Paranasal sinuses 109 Pharynx 113 Larynx 119 Thyroid and parathyroid glands 124 Salivary glands 129 Temporomandibular joints 133 Vascular imaging 137 Head and neck imaging – key points 141 Chapter 9 Spine 142 Cervical spine 142 Thoracic spine 151 Lumbar spine 156 Whole spine imaging 162 Spine imaging – key points 166 Chapter 10 Chest 167 Lungs and mediastinum 167 Heart and great vessels 175 Thymus 186 Breast 189 Axilla 199 Brachial plexus 202 Chest imaging – key points 206 Chapter 11 Abdomen 207 Liver and biliary system 207 Kidneys and adrenal glands 215 Pancreas 222 Bowel 227 Vascular imaging 232 Abdominal imaging – key points 235 Chapter 12 Pelvis 236 Prostate 236 Rectum and testes 244 Uterus and cervix 247 Pelvic imaging – key points 251 Chapter 13 Upper Limb 252 Shoulder 252 Humerus 262 Elbow 268 Forearm 276 Wrist and hand 281 Upper limb imaging – key points 288 Chapter 14 Lower Limb 289 Hips 289 Femur 298 Knee 303 Tibia and fibula 311 Ankle 316 Foot 323 Vascular imaging 328 Lower limb imaging – key points 334 Chapter 15 Paediatric Imaging 335 Introduction 335 Creating the right environment 335 Sedation and anaesthesia 337 The MRI examination 345 Conclusion 375 Paediatric imaging – key points 375 Index 376

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Book SynopsisThe derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities. Over recent years, a number of powerful two-dimensional NMR techniques (e.g.Table of ContentsPreface vii List of Figures xi List of Tables xv 1 NMR Spectroscopy Basics 1 1.1 The Physics of Nuclear Spins 1 1.2 Basic NMR Instrumentation and the NMR Experiment 4 2 One-Dimensional Pulsed Fourier Transform NMR Spectroscopy 5 2.1 The Chemical Shift 7 2.2 1H NMR Spectroscopy 9 2.2.1 Chemical Shifts in 1H NMR Spectroscopy 9 2.2.2 Spin-Spin Coupling in 1H NMR Spectroscopy 10 2.2.3 Decoupling in 1H NMR Spectroscopy 15 2.2.4 The Nuclear Overhauser Effect in 1H NMR Spectroscopy 16 2.3 Carbon-13 NMR Spectroscopy 16 2.3.1 Decoupling in 13C NMR Spectroscopy 17 2.3.2 Chemical Shifts in 13C NMR Spectroscopy 18 2.4 Fluorine-19 NMR Spectroscopy 19 2.5 Phosphorus-31 NMR Spectroscopy 22 2.6 Nitrogen-15 NMR Spectroscopy 23 3 Two-Dimensional NMR Spectroscopy 25 3.1 General Principles 25 3.2 Proton-Proton Interactions 28 3.2.1 Correlation Spectroscopy – The COSY Experiment 28 3.2.2 Total Correlation Spectroscopy – The TOCSY Experiment 30 3.2.3 Nuclear Overhauser Spectroscopy – The NOESY Experiment 31 3.3 Carbon-Carbon Interactions 35 3.3.1 The INADEQUATE Experiment 35 3.4 Heteronuclear Correlation Spectroscopy 37 3.4.1 Heteronuclear Single Bond Correlation – The HSQC, HMQC and me-HSQC Experiments 37 3.4.2 Heteronuclear Multiple Bond Correlation – HMBC 38 4 Miscellaneous Topics 45 4.1 NMR Solvents 45 4.2 Reference Compounds and Standards 47 4.3 Dynamic Processes 48 4.3.1 Protons on Heteroatoms 49 4.3.2 Rotation about Partial Double Bonds 50 4.4 Second-Order Effects 51 4.5 Effect of a Chiral Centre on NMR Spectra 51 5 Worked Examples 55 5.1 General Principles 55 5.2 Worked Example 1 57 5.3 Worked Example 2 63 Problems 71 Index 309

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Book SynopsisPsychiatry: Breaking the ICE contains everything psychiatry trainees need in order feel confident and competent in general adult inpatient and community placements.Table of ContentsContributors, xi Foreword, xv Acknowledgements, xvii Abbreviations, xix About the companion website, xxi Part I: Introduction 1 Welcome, 3Sarah Stringer 2 Mental health services overview, 5Christina Barras, Rory Conn, Laurine Hanna, Abigail G Crutchlow, and Juliet Hurn 3 Your team, 9Christina Barras, Rory Conn, Laurine Hanna, and Abigail G Crutchlow 4 Your role, 13Christina Barras, Rory Conn, Laurine Hanna, and Abigail G Crutchlow 5 Getting started, 16Mujtaba Husain, Christina Barras, Rory Conn, and Laurine Hanna 6 Safety and verbal de-escalation, 19Sarah Stringer 7 Boundaries, time management and burnout, 25Sarah Stringer, Christina Barras, Rory Conn, and Laurine Hanna 8 Psychiatric assessment, 31Sarah Stringer, Mujtaba Husain, Penelope Brown, and Sean Cross 9 Management: General principles, 45Sarah Stringer 10 Physical healthcare, 48Katherine Beck, Stephanie Young, and Juliet Hurn 11 Medications, 53Noreen Jakeman and Sarah Stringer 12 Psychological interventions, 65Jane Bunclark, Natasha Liu-Thwaites, Cheryl Kipping, Juliet Hurn, and Sarah Stringer 13 Social interventions, 83Christina Barras, Rory Conn, Laurine Hanna, Abigail G Crutchlow, Juliet Hurn, Rachel Thomasson, and Anna M Burnside 14 Handovers, 96Rachel Thomasson 15 Mental health legislation, 97Penelope Brown, Peter Hindley, and Anna M Burnside 16 Compliments, complaints and serious incidents, 107Anna M Burnside and Sarah Stringer 17 Training in psychiatry, 110Mujtaba Husain, Juliet Hurn, Rachel Thomasson, Christina Barras, Rory Conn, Laurine Hanna, and Sarah Stringer Part II: Common tasks COMMUNITY MENTAL HEALTH TEAM (CMHT) 18 Outpatient clinics, 123Christina Barras, Rory Conn, and Laurine Hanna 19 Care programme approach (CPA) meetings, 127Abigail G Crutchlow, Christina Barras, Rory Conn, and Laurine Hanna 20 Home visits, 130Laurine Hanna 21 Depression, 133Rory Conn and Rachel Thomasson 22 Generalised anxiety disorder (GAD), 141Laurine Hanna 23 First episode psychosis (FEP), 147Christina Barras and Juliet Hurn 24 Psychosis – longer term, 154Stephanie Young 25 Bipolar affective disorder (BPAD), 159Rory Conn and Juliet Hurn 26 Emotionally unstable personality disorder (EUPD), 165Jane Bunclark and Juliet Hurn 27 Non-engagement or disengagement, 174Rory Conn 28 Patients with forensic histories, 179Penelope Brown 29 Pregnancy, 183Anna M Burnside and Noreen Jakeman 30 Older adults, 189Vivienne Mak and Sean Lubbe 31 Trauma and asylum, 196Laurine Hanna and Juliet Hurn 32 Driving, 203Christina Barras 33 Discharge, 208Laurine Hanna WARD 34 From admission to discharge, 212Katherine Beck and Abigail G Crutchlow 35 Ward rounds, 221Katherine Beck 36 Common side effect management, 225Katherine Beck, Noreen Jakeman, and Sarah Stringer 37 Clozapine, 235Stephanie Young and Noreen Jakeman 38 Self-discharge and section 5(2), 242Abigail G Crutchlow 39 Seclusion reviews, 246Katherine Beck 40 Alcohol misuse, 251Lisa Conlan, Isabel McMullen, and Cheryl Kipping 41 Illicit drugs, 259Isabel McMullen, Lisa Conlan, and Cheryl Kipping 42 Pregnant patients, 265Anna M Burnside 43 Inpatients with forensic histories, 269Penelope Brown 44 People with learning disabilities (LD), 274Rory Sheehan 45 Emotionally unstable personality disorder (EUPD), 281Jane Bunclark and Juliet Hurn 46 Older adults, 287Vivienne Mak and Sean Lubbe 47 Electroconvulsive therapy (ECT), 293Sean Lubbe and Vivienne Mak 48 Section 136 assessments, 298Anna M Burnside 49 Tribunals, 303Sarah Stringer ON-CALL 50 Your first on-call shift, 307Rachel Thomasson, Sean Cross, and Anna M Burnside 51 Self-harm, 318Rachel Thomasson, Jane Bunclark, Sean Cross, Rory Conn, and Christina Barras 52 Self-harm in young people, 330Peter Hindley and Matthew Fernando 53 First episode psychosis (FEP), 336Rachel Thomasson 54 Mania, 341Rachel Thomasson 55 Delirium, 345Vivienne Mak, Sean Lubbe, and Sean Cross 56 Obsessive compulsive disorder (OCD), 353Natasha Liu-Thwaites and Rachel Thomasson 57 Panic attacks, 357Natasha Liu-Thwaites 58 Drug-seeking, 361Isabel McMullen and Lisa Conlan 59 Learning disability (LD) and behavioural change, 365Rory Sheehan 60 ‘Social’ presentations, 369Sean Cross and Rachel Thomasson 61 Medically unexplained symptoms, 374John Moriarty Part III: Emergencies COMMUNITY MENTAL HEALTH TEAM (CMHT) 62 Acute relapse, 383Laurine Hanna 63 Adult safeguarding, 388Rory Conn, Vivienne Mak, and Sean Lubbe WARD 64 Child protection concerns, 394Peter Hindley, Juliet Hurn, and Sarah Stringer 65 Medical emergencies, 401Katherine Beck and Abigail Steenstra 66 Opiate overdose, 405Isabel McMullen and Lisa Conlan 67 Stiff, feverish patients, 408Anna M Burnside 68 Catatonia, 414Anna M Burnside 69 Lithium toxicity, 418Noreen Jakeman and Katherine Beck 70 Alleged sexual assault, 422Anna M Burnside, Sarah Stringer, and Penelope Brown 71 Self-harm on the ward, 428Jane Bunclark and Abigail Steenstra 72 Hanging, 433Anna M Burnside 73 Death, 436Katherine Beck ON-CALL 74 Aggression, 440Abigail G Crutchlow, Christina Barras, Noreen Jakeman, Sean Lubbe, Vivienne Mak, Rachel Thomasson, and Abigail Steenstra 75 Challenging behaviour in children, 451Peter Hindley and Matthew Fernando 76 Refusal of urgent treatment, 455Vivienne Mak, Sean Cross, Sean Lubbe, and Rachel Thomasson 77 Delirium tremens, 461Rachel Thomasson, Isabel McMullen, and Lisa Conlan 78 Puerperal psychosis, 466Anna M Burnside 79 Eating disorders, 470Christina Barras and Sean Cross 80 Threats of violence, 477Penelope Brown and Rachel Thomasson Appendices Appendix A Investigations/Monitoring, 485 Juliet Hurn, Noreen Jakeman, Anna M Burnside, and Abigail Steenstra Table A.1 Overview of physical health monitoring in Severe Mental Illness (SMI), 485 Table A.2 Delirium investigations, 486 Table A.3 First episode psychosis investigations, 487 Table A.4 Baseline checks before starting psychotropics, 488 Table A.5 Ongoing monitoring - antipsychotics, 489 Table A.6 Ongoing monitoring - mood stabilisers, 490 Table A.7 Rapid tranquilisation (RT) cautions and contraindications, 490 Table A.8 Monitoring after RT, 491 Appendix B Medications, 492Noreen Jakeman and Sarah Stringer Table B.1.1 Oral antipsychotics–approximate relative side effects, 492 Table B.1.2 Depot antipsychotics–approximate relative side effects, 493 Table B.2 Common oral antipsychotics–key information, 494 Table B.3 Common depot antipsychotics–key information, 496 Table B.4 Selective Serotonin Reuptake Inhibitors (SSRIs)–key information, 498 Table B.5 Non-SSRI antidepressants–key information, 499 Table B.6 Mood Stabilisers–key information, 502 Table B.7 Sedatives–key information, 504 Appendix C Alcohol and drugs, 505 Table C.1 Quick guide to alcohol units (Cheryl Kipping), 505 Table C.2 Alcohol Use Disorders Identification Test (AUDIT) questionnaire, 506 Table C.3 Severity of Alcohol Dependence Questionnaire (SADQ), 508 Table C.4 Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised (CIWA-Ar), 509 Table C.5 Clinical Opiate Withdrawal Scale (COWS), 511 Table C.6 Common illicit drugs summary, 513 Appendix D Cognitive testing, 515 Appendix D.1 The Montreal Cognitive Assessment (MOCA), 515 Appendix D.2 The Addenbrooke’s Cognitive Examination-III (ACE-III), 516 Appendix D.3 The Mini-Addenbrooke’s Cognitive Examination (M-ACE), 530 Appendix E Mental health legislation, 532Anna M Burnside & Penelope Brown, with thanks to Daniel M Bennett and Edward Noble Table E.1 The Mental Health (Care and Treatment) (Scotland) Act 2003: common civil sections, 532 Table E.2 The Mental Health (Northern Ireland) Order 1986: common sections (Part II), 534 Table E.3 The Mental Health Act 1983, amended 2007 (England & Wales): forensic sections, 537 Appendix F Useful contacts, 539 Index, 541

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Book SynopsisThe fast and easy way to explore a medical transcription career Flexibility is one of the most enticing aspects of a career in medical transcription. Perfect for in the office, at home, or on vacation, medical transcriptionists can often create lifestyle-appropriate schedules.Table of ContentsIntroduction 1 Part I: So, You Want to Be a Medical Transcriptionist 7 Chapter 1: Just the Facts 9 Chapter 2: The What, How, Who, and Why of Medical Transcription 17 Chapter 3: Getting a Handle on Job Prospects and Employment Options 35 Chapter 4: Becoming a Working Medical Transcriptionist 49 Part II: Getting the Job Done: Medical Transcription How-To 65 Chapter 5: Medical Language Boot Camp 67 Chapter 6: Formatting: The Basics 85 Chapter 7: Cracking the Code: Deciphering Diffi cult Dictation 101 Chapter 8: Mastering the Key Medical Transcription References 109 Chapter 9: Meeting the Need for Speed 123 Part III: Looking at the Types of Reports You’ll Transcribe 131 Chapter 10: History and Physical Examination 133 Chapter 11: Consultation 143 Chapter 12: Operative Reports 151 Chapter 13: Discharge and Death Summaries 161 Chapter 14: Beyond the Big Four: Other Common Reports 169 Part IV: Employment Matters: Landing and Managing a Medical Transcriptionist Job 189 Chapter 15: Medical Transcriptionist Job Hunting 191 Chapter 16: Managing On-the-Job Issues 205 Chapter 17: Climbing the Career Ladder 215 Chapter 18: Working from Home 223 Chapter 19: Financial Considerations for Independent Contractors 239 Chapter 20: Staying Healthy for the Long Haul 255 Part V: The Part of Tens 265 Chapter 21: Ten Keys to Career Success 267 Chapter 22: Ten Myths about Medical Transcription 275 Chapter 23: Ten Great Online Resources281 Part VI: Appendixes 285 Appendix A: Glossary 287 Appendix B: Commonly Dictated Phrases and How to Transcribe Them299 Appendix C: Sample Reports 309 Index 325

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Book Synopsis

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Book SynopsisSuitable for researchers across science and medicine using rat models in the laboratory setting, this book offers an added emphasis on the Sprague-Dawley and Wistar rat strains, in line with research across academia, government and industry.Table of ContentsSection I: Digestive System Section II: Liver and Exocrine Pancreas Section III: Urinary Tract Section IV: Nervous System and Special Sense Organs Section V: Musculoskeletal System Section VI: Integumentary System Section VII: Mammary Gland Section VIII: Respiratory Tract Section IX: Immune System Section X: Bone Marrow Section XI: Female Reproductive Tract Section XII: Male Reproductive System Section XIII: Circulatory System Section IIV: Endocrine System Section IX: Historical Data

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Book SynopsisThis book acts as a clinical manual for the diagnostician who cannot turn to reference books when the morphology or immunophenotype are atypical.Trade Review“I would particularly recommend this book to haematology trainees, as an introduction to, but not as a replacement for, a period spent in an immunophenotyping laboratory.” (British Journal of Haematology, 14 November 2014) “There is no doubt that this book will find its way firmly onto the bookshelf in every laboratory, and into the work bags of many trainees.” (Haem Trainee, 1 January 2014) “This is a concise and very practical guide to the use of flow cytometry in hematological and hematopathological diagnosis. While not as detailed in immunophenotyping intricacies as other books of its kind, it shines with its practical approach and expert guidance applied to current clinical practice.” (Doody’s, 19 July 2013)Table of ContentsPreface, vii Acknowledgements, viii 1 Introduction, 1 References, 2 2 Principles of Flow Cytometry, 3 Introduction, 3 Sample preparation, 3 The flow cytometer, 4 The fluidic system, 4 The optical system, 5 The electronic system, 9 Data display, 9 Acknowledgements, 18 References, 19 3 Limitations, 20 Introduction, 20 Clinical context issues, 20 Sampling issues, 20 Technical issues, 25 Interpretation issues, 28 Conclusion, 29 References, 29 4 Normal Blood and Bone Marrow Populations, 31 Normal stem and precursor cell populations, 31 References, 41 5 Acute Leukaemia, 43 Introduction, 43 Identification of neoplastic precursor cells, 45 Lineage assignment of acute leukaemia, 52 Acute myeloid leukaemia, 54 Precursor lymphoid neoplasms (acute lymphoblastic leukaemia/lymphoma), 77 Examination of cerebro-spinal fluid and serous effusions, 88 Identification of genetic abnormalities by flow, 92 Conclusion, 93 References, 93 6 Chronic Lymphoid Leukaemias and Exfoliating Lymphoma, 100 Normal peripheral blood lymphoid populations, 100 Identification of clonal lymphoid populations, 101 Identification of clonal B-cell disorders, 101 CD5 positive B-cell lymphoproliferative disorders, 102 CD10 positive B-cell lymphoproliferative disorders, 116 B-cell disorders identified using an extended B-cell panel, 121 Identification of clonal T-cell disorders, 125 CD4 positive T-cell disorders, 128 CD8 positive T-cell disorders, 136 CD4/CD8 positive T-cell disorders, 141 CD4/8 negative disorders, 141 Flow cytometric assessment of serous effusions, 146 Flow cytometric assessment of cerebrospinal fluid, 146 Summary, 149 References, 149 7 Myelodysplastic Syndromes and Myeloproliferative Neoplasms, 152 Introduction, 152 Myelodysplastic syndromes, 152 Myelodysplastic/myeloproliferative neoplasms, 163 Chronic myeloid leukaemia, 165 The BCR-ABL negative myeloproliferative neoplasms, 166 Mastocytosis, 167 Summary, 170 References, 170 8 Disorders of Plasma Cells, 173 Plasma cell disorders, 173 Current diagnostic criteria, 173 Plasma cell morphology, 175 The applications of immunophenotyping to plasma cell disorders, 178 References, 183 9 Minimal Residual Disease, 184 Introduction, 184 Minimal residual disease analysis in the management of acute lymphoblastic leukaemia, 187 Conclusions, 199 Acknowledgements, 200 References, 200 10 Red Cells, Leucocytes and Platelets, 202 Paroxysmal nocturnal haemoglobinuria, 202 Red cell membrane disorders, 208 Foetal maternal haemorrhage, 211 Lymphocyte subset analysis and immunodeficiency, 214 Haemopoietic stem cell enumeration, 214 Granulocyte disorders, 215 Platelet disorders, 219 References, 221 11 Reactive and Non-neoplastic Phenomena, 225 Peripheral blood, 225 Bone marrow, 231 Pleural and pericardial fluids, 236 Bronchoalveolar lavage specimens, 238 Cerebrospinal fluid, 238 References, 240 Index, 243

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Book SynopsisTrade Review"Drs Tom Lissauer and Will Carroll have produced a very much wanted text, by putting together what committed professionals need to know. The book is most desirable tool for the candidates preparing for examinations and interviews.” "highly recommended to anyone studying for or taking the relevant examinations but also to others able to use it appropriately as a resource in day-to-day practice." "Drs Tom Lissauer and Will Carroll have produced a very much wanted text, by putting together what committed professionals need to know. The book is most desirable tool for the candidates preparing for examinations and interviews." - British Association for Community Child Health (BACCH) NewsletterTable of ContentsIntroduction - The important role of science and research in paediatrics Epidemiology and public health History and examination Normal child development Developmental problems and the child with special needs Paediatric emergencies and critical care Accidents and poisoning Child protection Genetics Perinatal medicine Neonatal medicine Growth and puberty Nutrition Gastroenterology Infection and immunity Allergy Respiratory medicine Cardiology Nephrology Genitalia Hepatology Oncology Haematology Emotions and behaviour Dermatology Diabetes and endocrinology Musculoskeletal disorders Neurology Metabolic medicine Ophthalmology Hearing and balance Adolescent medicine Global child health Palliative medicine Ethics Pharmacology and therapeutics Clinical research Statistics Evidence based paediatrics Quality improvement and the clinician

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Book SynopsisWhen faced with a challenging dermatologic problem, physicians are often required to perform a time-consuming search through large dermatologic texts in order to find information that will assist in the necessary differential diagnosis. This comprehensive and concise handbook is designed to simplify this process dramatically, permitting rapid identification of the correct diagnosis. Hundreds of dermatologic diagnoses, morphologic features, drug-induced disorders, extracutaneous manifestations, histologic findings, and random other findings are listed in alphabetical order and in a homogeneous, reader-friendly structure. The differential diagnoses are shown under each main diagnosis, sorted according to similarity with that diagnosis. Since the first edition, approaching 50 new diagnoses have been added, and many new images included. This easily portable book will be of great value for dermatologists and all who deal with dermatologic diseases.Table of ContentsThe Chief Complaint.- The Past Medical History, Social History, and Review of Systems.- The Physical Exam.- The Biopsy.- The Laboratory Results.- The Diagnosis.- Quick Glossary.

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