Clinical and internal medicine Books
Johns Hopkins University Press Eating Disorders
Book SynopsisTable of ContentsPreface, by Philip S. Mehler and Arnold E. Andersen1. Diagnosis and Treatment of the Eating Disorders Spectrum in Primary Care Medicine, by Arnold E. Andersen2. The Role of the Multidisciplinary Team and Levels of Care in the Treatment of Eating Disorders, by Craig Johnson, Jeana Cost, Russell Marx, Kenneth Weiner, Nathalia Trees, and Philip S. Mehler3. Medical Evaluation of Patients with Eating Disorders, by Kristine Walsh and Philip S. Mehler4. Nutritional Rehabilitation: Practical Guidelines for Refeeding Patients with Anorexia Nervosa, by Meghan Foley, Shelby Sitko, and Philip S. Mehler5. Evaluation and Treatment of Electrolyte Abnormalities, by Dennis Gibson and Philip S. Mehler6. Gastrointestinal Complications, by Dennis Gibson, Leah Puckett, and Philip S. Mehler7. Cardiac Abnormalities and Their Management, by Katherine V. Sachs, Philip S. Mehler, and Mori Krantz8. Obstetric-Gynecologic Endocrinology and Osteoporosis, by Philip S. Mehler9. General Endocrinology, by Philip S. Mehler10. The Dual Diagnosis of Eating Disorder and Diabetes Mellitus, by Ovidio Bermudez, Jennifer McBride, and Philip S. Mehler11. Oral, Dental, Ear, and Eye Complications, by Jeffrey Hollis and Philip S. Mehler12. Athletes and Eating Disorders, by Arnold E. Andersen and Jeana Cost13. Males with Eating Disorders, by Arnold E. Andersen14. Special Considerations for Eating Disorders in Children and Young Adolescents, by Anna B. Tanner and Michael Spaulding-Barclay15. Atypical Anorexia Nervosa, by Neville Golden16. Eating Disorders in Transgender Individuals, by Arnold E. Andersen17. Using Medical Information Psychotherapeutically, by Arnold E. Andersen18. Ethical and Medicolegal Considerations in Treating Patients with Eating Disorders, by Patricia Westmoreland and Jessica Tse19. Medical Information for Nonmedical Clinicians and Educators, by Arnold E. Andersen20. Innovative Psychological Treatments of Eating Disorders, by Arnold E. Andersen21. Family-Based Treatment for Eating Disorders, by Daniel Le Grange and Sasha GorrellList of ContributorsAcknowledgmentsIndex
£37.35
John Wiley and Sons Ltd UICC Manual of Clinical Oncology
Book SynopsisThe Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world. Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care. Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary canTable of ContentsForeword x Preface xi About the Editors xiii Contributors xvi PART 1 General principles of cancer diagnosis and management 1 Principles of knowledge generation and translation 1 – Cancer epidemiology 3 2 – Levels of evidence, guidelines and standards 12 3 – Prognosis and classification of cancer 23 4 – Principles of cancer staging 34 5 – Assessment of treatment outcome 40 6 – Cancer informatics 53 Principles of cancer diagnosis 7 – Imaging 63 8 – Pathology 83 Principles of treatment 9 – Principles of surgery 98 10 – Principles of radiotherapy 108 11 – Principles of systemic therapy 124 Special settings, supportive care and survivorship 12 – Treatment in pregnancy 134 13 – Treatment in the elderly 139 14 – Oncology emergencies 145 15 – Supportive care during curative treatment 155 16 – Pain management in cancer 168 17 – Palliative care 174 18 – Survivorship 184 19 – Rehabilitation 194 PART 2 Site-specific multidisciplinary cancer management 203 Thoracic malignancies 20 – Lung 205 Breast 21 – Breast 221 Gastrointestinal malignancies 22 – Liver 241 23 – Biliary tract and pancreas 263 23.1 – Biliary tract 263 23.2 – Pancreas 270 24 – Oesophagus 280 25 – Stomach 297 26 – Colon, rectum and anus 308 26.1 – Colon and rectum 308 26.2 – Anus 327 Genitourinary malignancies 27 – Prostate 333 28 – Bladder and other urothelium 343 29 – Kidney 354 30 – Testicular germ cell tumours 368 31 – Penis 384 Haematological malignancies 32 – Lymphoma 392 33 – Myeloma 415 34 – Leukaemia 427 Gynaecological cancers 35 – Cervix 449 36 – Uterus 467 37 – Ovary and fallopian tube 479 Head and neck cancer 39 – General principles of head and neck cancer management 503 40 – Nasopharynx 512 41 – Oral cavity 524 42 – Larynx and hypopharynx 542 43 – Oropharynx 559 44 – Major salivary glands 571 45 – Nasal cavity and paranasal sinus 586 46 – Head and neck unknown primary 597 Endocrine tumors 47 – Pituitary 609 48 – Thyroid 626 49 – Adrenal tumours 641 50 – Neuroendocrine tumours 656 Dermatological cancer 51 – Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma 674 52 – Melanoma 689 Central nervous system and ocular cancers 53 – Central nervous system 706 54 – Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymph Sarcoma 55 – Bone (osteosarcoma) 745 56 – Soft tissue 754 Childhood malignancies 57 – Paediatric tumors 768 Specific cancer situations 58 – Cancer of unknown primary (no 59 – HIV and transplant-related neoplasms 797 59.1 – HIV-related neoplasms 797 59.2 – Post-transplantation lymphoproliferative disease 809 59.3 – Cancer following solid organ transplantation 812 Index 815
£130.45
Springer London Ltd Hearing Loss in the Elderly
Book SynopsisIn their preface, the authors highlight the great social and medical importance of hearing loss in the elderly, an ever-increasing prob lem. It is, therefore, most appropriate that a monograph, devoted to research in this field, features as an addition to the Bloomsbury Series in Clinical Science. Written by two leading authorities, the book reviews the past and present literature, details the clinical aspects and considers the electrophysiological and histopatho logical issues basic to the overall problem. It continues the high standard and excellence fostered by previous issues in the Series. London, August 1990 Jack Tinker Preface The number of very old people in the community is steadily increasing so the hearing loss that many of them endure has become a disorder of social and medical importance. Only by a greater scientific knowledge of old age deafness can there be any posTable of Contents1 Review of Literature.- Up to the Early Twentieth Century.- Recent Times.- Localization of the Disturbance.- Central.- Peripheral.- Aetiological Basis for the Disturbance.- Role of Exogenous Factors.- Summary.- Localization.- Aetiological Basis.- 2 Clinical Diagnosis and Audiometric Studies.- Clinical Dignosis.- History.- Examination of the Ear.- Clinical Speech Tests.- Tuning Fork Methods.- Audiogram.- Tympanometry.- X-Rays.- Electrophysiology.- Calorics and Electronystagmography.- Disorders of the External Ear.- Disorders of the Middle Ear.- Disorders of the Inner Ear.- Presbyacusis.- Noise Induced Hearing Loss.- Ototoxicity.- Bone Lesions of the Otic Capsule.- Acoustic Neuroma.- Tinnitus.- Audiometric Studies.- Personal Investigations.- Hearing Levels in a Large Group of Elderly People.- Comparison of Hearing Levels in Different Medical and Environmental Conditions.- 3 Electrophysiology.- (In collaboration with S.M. Mason).- Extratympanic Electrocochleography.- Detailed Investigation of ABR; Preliminary Investigation of ECochG.- Procedure.- Results.- Discussion.- Summary.- Simultaneous Recordings of ABR and ECochG; Detailed Investigation of ECochG Components.- Procedure.- Results.- Discussion.- Conclusions.- Summary.- Stimulus Rate Effects.- Procedure.- Results.- Discussion.- 4 Histopathological Changes.- Perfusion-Fixation and Slicing of Inner Ear.- Staining of Surface Preparations.- Preliminary Survey of Morphological Changes in Elderly Cochleas.- Procedure.- Results.- Discussion.- Quantitative Analysis of Hair Cell Changes.- Procedure.- Results.- Discussion.- Summary of Histopathological Changes.- 5 Summing-up.
£40.49
Springer-Verlag New York Inc. Chronic Ambulatory Peritoneal Dialysis CAPD and Chronic Cycling Peritoneal Dialysis CCPD in Children
Book SynopsisDuring the past decade, there has been a renaissance of interest in the use of peritoneal dialysis as a primary dialytic modality for the treatment of children with end stage renal disease (ESRD). The development of the technique of continuous ambulatory peritoneal dialysis (CAPD) and continuous cycling peritoneal dialysis (CCPD) has markedly changed the approach to children requiring dialytic therapy. The availability of these techniques has facilitated prolonged dialysis in infants and has for the first time given pediatric nephro logists in many areas of the world an opportunity to consider dialysis in chil dren afflicted with ESRD. I have enlisted the collaboration of colleagues from Europe, South America, Canada, and the United States in compiling this multidisciplinary text, which hopefully contains the most up-to-date, comprehensive information regarding the use of CAPD/CCTable of Contents1. The use of peritoneal dialysis in Europe for treatment of children with end stage renal disease—EDTA registry data.- 2. Demographic data on the use of CAPD/CCPD as a primary dialytic therapy in children in the United States.- 3. Pediatric CAPD in developing countries.- 4. Developmental aspects of peritoneal dialysis kinetics.- 5. Peritoneal dialysis kinetics in children.- 6. Kinetics of CCPD in children.- 7. CAPD in infants.- 8. Technical aspects of CAPD/CCPD.- 9. Peritoneal catheter: technique, logevity, complications.- 10. Continuous ambulatory peritoneal dialysis in children; biochemical control of uremia, anemia, hypertension, lipid metabolism, glucose tolerance, and endocrine abnormalities.- 11. The role of the nurse in CAPD/CCPD training.- 12. Complications of CAPD/CCPD in pediatric patients.- 13. Peritonitis in infants and children on CAPD/CCPD.- 14. Loss of ultrafiltration and sclerosing encapsulating peritonitis in children undergoing CAPD/CCPD.- 15. Long-term function of the peritoneal membrane.- 16. Nutritional recommendations for children treated with CAPD/CCPD.- 17. The role of the dietitian in the management of children undergoing CAPD/CCPD.- 18. Supplemental (NG) feedings of infants undergoing continuous peritoneal dialysis.- 19. Protein losses during CAPD in children: the role of dialysates containing amino acids.- 20. Control of renal bone disease by high-dose calcitriol and the use of calcium carbonate as a phosphate-binding agent in children on CAPD/ CCPD.- 21. Growth in children on CAPD.- 22. Comparison of CAPD and hemodialysis in children.- 23. Comparison of CAPD and CCPD in children.- 24. Transplantation in children undergoing CAPD and CCPD.- 25. Promoting psychosocial adaptation to continuous ambulatory peritoneal dialysis/continuous cylcing peritoneal Dialysis in Children and Adolescents.
£116.99
Springer-Verlag New York Inc. Suki and Massrys Therapy of Renal Diseases and Related Disorders
Book Synopsisstories of postwar nephrology and metabolism. Postwar Uremia is to the nephrologist what the baby is to the nephrology rushed to the fore and supplied nephrologists pediatrician, for it is the final common pathway of literally with such wonderful tools as the flamephotometer, electro- hundreds of disease processes that lead to scarring and destruction of nephrons. . phoresis, microchemistry, immunoassay, sonography, renal biopsy, immunofluorescence, electron microscopy, and un- We estimate that there are well in excess of 300,000 clear magnetic resonance, and permitted a total integration patients in the world living on the varied methodologies of form, histologic structure, and function. Clinical represented by the three basic forms of substituted kidney nephrology became indeed the real fusion of biochemistry, function-hemodialysis, peritoneal dialysis, and renal physiology, immunology, renal endocrinology, and the transplantation: over 100,000 persons in the United States focus of nTable of ContentsPart One: Disorders of Fluid, Electrolyte, and Acid-Base Balance. Part Two: Intrinsic Parenchymal Disease. A: Glomerular. B: Tubulointerstitial. Part Three: Renal Involvement in Systemic Disease. Part Four: Hereditary and Congenital Diseases. Part Five: Neoplasia. Part Six: Chemical and Physical Injuries. Part Seven: Chronic Renal Failure. A: Medical Therapy. B: Peritoneal Dialysis. C: Hemodialysis. D: Transplantation. Part Eight: Hypertension. Part Nine: Urologic Disorders. Index.
£40.49
iUniverse White Shadow: Walking with Janet Mentgen
Book Synopsis
£19.90
Brush Education Inc Vancouver Notes for Internal Medicine: High-Yield
Book SynopsisA point-of-care guide for internal medicine trainees. When students and residents begin a new rotation in internal medicine, they often start from scratch, relying on their own research to prepare for consultations. What questions are crucial during history taking? What should the physical examination and investigations focus on? What should the consultation write-up include? Now, physician learners can turn to Vancouver Notes for Internal Medicine for guidance on conducting consultations in each of the core internal medicine subspecialties. Vancouver Notes provides learners with an organized approach to common presentations in internal medicine. For each subspecialty, it lays out the process for identifying key information and communicating findings and management recommendations to a patient’s health-care team. Developed through the efforts of more than 90 resident physicians and faculty members at the University of British Columbia, Vancouver Notes combines valuable clinical pearls in a single, accessible resource to give students and residents the tools they need to succeed from day one.
£40.00
Thieme Medical Publishers Inc Vascular Lesions of the Head and Neck: Diagnosis and Management
Book SynopsisThieme congratulates Milton Waner on being chosen by New York magazine for its prestigious 'Best Doctors 2017' list. Vascular Lesions of the Head and Neck provides readers with an up-to-date review of the pathology, basic science, classification, radiologic features, and treatment modalities for vascular lesions of the head and neck. It covers all recent developments in medical and surgical treatment, laser technology, endovascular techniques, and appropriate radiation protocols that dramatically affect the evaluation and management of patients with vascular lesions. Key Features: Written by leading experts on the diagnosis and treatment of vascular lesions in the fields of otolaryngology, plastic surgery, radiology, dermatology, pathology, and pediatrics Emphasizes a multidisciplinary approach to the diagnosis and treatment of vascular lesions More than 200 full-color illustrations help clarify information in the text This book is an excellent desk reference for all otolaryngologists, plastic surgeons, vascular interventional radiologists, pediatricians, dermatologists, pathologists, and general pediatric surgeons involved in the treatment of patients with vascular lesions of the head and neck. Table of Contents1 Classification of Vascular Anomalies 2 Congenital Vascular Tumors 3 Pathology of Congenital Vascular Lesions 4 The Natural History, Physical Findings, and Evaluation of Hemangiomas 5 Hemangioma Syndromes 6 Radiologic Evaluation of Hemangiomas 7 Medical Management of Hemangiomas 8 Treatment of Infantile Hemangiomas 9 Radiologic Evaluation of Vascular Malformations 10 The Role of Endovascular Surgery in the Management of Vascular Lesions of the Head and Neck 11 Treatment of Port-Wine Stains 12 The Surgical Management of Vascular Malformations 13 Evaluation and Treatment of Vascular Neoplasms 14 Pathology of Acquired Vascular Neoplasms of the Head and Neck
£73.15
JP Medical Ltd Short and OSCE Cases in Internal Medicine
Book SynopsisThe second edition of this book is a practical revision guide for postgraduate students preparing for clinical examinations in internal medicine. Authored by an experienced postgraduate examiner, the book presents a series of short and OSCE cases presented in a uniform format, offering guidance on examination techniques, common mistakes made by candidates, and typical presentation of findings. Divided into seven sections, the book begins with advice on how to prepare for and pass clinical examinations. The remaining chapters cover cases relevant to different systems of the body – cardiovascular; respiratory; abdominal; neurological; endocrine, rheumatologic, connective tissue and skin; and eye and fundus. Each case provides a summary of diagnosis, differential diagnosis, management, and further information often required in examinations. The questions and model answers are similar to those most frequently encountered in examinations. The comprehensive text is enhanced by illustrations and figures to assist learning and will be useful not only to candidates preparing for postgraduate clinical examinations, but also to undergraduate students. Key points Practical revision guide for postgraduate students preparing for clinical examinations in internal medicine Questions and model answers similar to those encountered in examinations Authored by experienced postgraduate examiner Previous edition (9789386150035) published in 2016 Table of Contents Foreword Preface to the 2nd edition Preface to the 1st edition Dedication Important note Acknowledgements List of abbreviations Part 1: Advice on how to prepare for and pass clinical examinations Part 2: Cardiovascular cases Part 3: Respiratory cases Part 4: Abdominal cases Part 5: Neurology cases Part 6: Endocrine, rheumatology, connective tissue and skin cases Part 7: Eye and fundus cases Index
£42.75
£20.96
Gillette Childrens Healthcare Press Epilepsy Understanding and Managing the
Book Synopsis
£42.75
Wolters Kluwer Health The Washington Manual of Outpatient Internal
Book SynopsisFocusing on the essential information you need to know for the most commonly encountered problems in outpatient internal medicine, this practical volume in the Washington Manual® series provides concise, high-yield content that reflects today’s advances in patient evaluation and management. In one convenient, portable resource, you’ll find complete coverage of everything from hypertension and diabetes to sleep disorders, nutrition, and care of the cancer patient—all at your fingertips for quick review and reference. Edited by Drs. Maureen D. Lyons, Peter J. McDonnell, and Jennifer M. Schmidt, The Washington Manual® of Outpatient Internal Medicine, 3rd Edition, is an excellent companion to the Washington Manual® of Medical Therapeutics, which thoroughly covers inpatient care. Covers common ambulatory/outpatient problems encountered in each medical subspecialty, all in the famous fast-access Washington Manual® outline format that includes easy-to-follow guidelines, diagrams, and algorithms. Thoroughly revised from cover to cover, including new content on telehealth, the trauma-informed approach, immunization reaction and allergy, functional assessment and safe prescribing for pain, breast masses, sexually transmitted infections, and more. Includes a new, full-color insert of dermatologic images to illustrate skin diagnoses and rashes. Addresses all areas of medicine and core subspecialties, including neurology and toxicology. Provides need-to-know diagnostic and therapeutic guidance from the outstanding house staff and faculty at Washington University School of Medicine in St. Louis. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University. Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.
£54.62
Wolters Kluwer Health Step-Up to Medicine
Book SynopsisMake the most of your study time and confidently take the next step in your medical career with this bestselling review.!Step-Up to Medicine, 6th Edition, makes it easy to find information fast and take a confident next step toward a successful medical career. Ideal for preparing for clerkships or clinical rotations, shelf exams, and the USMLE Step 2, this bestselling volume in the popular Step-Up series provides a high-yield review of medicine in a concise, comprehensive approach. This 6th Edition is thoroughly updated and enhanced throughout. Clinical pearls, full-color illustrations, and “Quick Hits” provide essential information in an efficient, easy-to-remember manner to ensure excellence on exams and confidence in clinical settings, and a 100-question practice exam reinforces exam readiness and boosts test-taking confidence. NEW! More than 50 additional NBME-style review questions with answers and explanations reinforce key content in context with how students will encounter it on their exams. UPDATED! New and enhanced images throughout—including expanded coverage of dermatology—clarify essential concepts in vibrant detail. UPDATED! Concise tables and figures summarize treatment protocols, drug details, and other essential information for fast, efficient review. NEW! Additional online review questions test students’ retention and alert them to areas requiring further study. “Quick Hits” help students save time and stay focused on core content.
£46.08
£56.69
Springer Nature Switzerland AG Endometriosis Pathogenesis, Clinical Impact and
Book SynopsisThis volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life.It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.Table of ContentsChapter 1. Endocrine disruptors and risk of endometriosis.- Chapter 2. Metabolomic characteristics in endometriosis patients.- Chapter 3. Can we diagnose early endometriosis with ultrasound rather than laparoscopy?.- Chapter 4. Neurotrophins and cytokines in endometriosis pain.- Chapter 5. Endometriosis induced pain: the treatment strategy.- Chapter 6. Management of endometriosis in teenagers.- Chapter 7. The etonogestrel contraceptive implant as a therapy for endometriosis.- Chapter 8. Impact of endometrioma surgery on ovarian reserve.- Chapter 9. What is the place of surgery of deep endometriosis in infertile and pelvic pain patients?.- Chapter 10. Endometriosis and Infertility: surgery and IVF: when, why and outcomes.- Chapter 11. ART and Endometriosis : problems and solutions.- Chapter 12. Morphokinetics in embryos from patients with endometriosis.- Chapter 13. Endometriosis and cancer: prevention and diagnosis.- Chapter 14. Medical management of endometriosis, present and future with special reference to MHT in the patient previously diagnosed with endometriosis.- Chapter 15. Endometriosis and Menopause: Realities and Management.
£71.99
Springer Nature Switzerland AG Pediatric Surgery: Diagnosis and Management
Book SynopsisThis comprehensive book provides detailed practical advice on the diagnosis and surgical management of congenital and acquired conditions in infants and children. Following the great success of the first edition, the new edition has been fully updated to reflect the major developments in the field of the past decade. Advances in prenatal diagnosis, imaging, anaesthesia and intensive care as well as the introduction of new surgical techniques, including minimally invasive surgery and robotic technology that have radically altered surgical conditions are now discussed in the book. In addition new chapters have been added on surgical safety in children, surgical problems of children with disabilities and surgical implications of HIV infection in children among others. This is a superbly structured and richly illustrated guide aimed at trainees, young pediatric surgeons and general surgeons with interest in pediatric surgery. The book also serves as a handy, quick and easy reference for those making decisions in daily practice. Pediatric Surgery, Diagnosis and Management features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields.Table of Contents1 The Epidemiology of Birth Defects.- 2 Prenatal Diagnosis and Fetal Counselling for Surgical Congenital Malformations.- 3 Transport of the Surgical Neonate.- 4 Pre-operative Management and Vascular Access.- 5 Anaesthesia and Analgesia.- 6 Fluid, Electrolyte and Respiratory Management.- 7 Sepsis.- 8 Nutrition.- 9 Access for Enteral Nutrition.- 10 Haematological Problems.- 11 Genetics.- 12 Ethical Considerations in Paediatric Surgery.- 13 Minimally Invasive Surgery in Infants and Children.- 14 Surgical Safety in Children.- 15 Surgical Problems of Children with Disabilities.- 16 Surgical Implications of HIV infection in Children.- Part II Trauma.- 17 Birth Trauma.- 18 Pediatric Thoracic Trauma .- 19 Abdominal and Genitourinary Trauma.- 20 Traumatic Head Injuries.- 21 Paediatric Orthopedic Trauma.- 22 Injuries to the Tendons.- 23 Burns.- 24 Foreign Bodies.- 25 Physical and Sexual Child Abuse.- Part III Head and Neck.- 26 Pierre Robin Sequence.- 27 Choanal Atresia.- 28 Thyroglossal and Branchial Cysts, Sinuses and Fistulas .- 29 Tracheostomy.- Part IV Chest.- 30 Chest Wall Deformities .- 31 Breast Disorders in Children and Adolescents.- 32 Congenital Airway Malformations.- 33 Mediastinal Masses in Children.- 34 Pleural Effusion and Empyema.- 35 Congenital Malformations of the Lung.- 36 Congenital Diaphragmatic Hernia.- 37 Extracorporeal Membrane Oxygenation.- Part V Esophagus .- 38 Esophageal Atresia and Tracheoesophageal Fistula.- 39 Gastroesophageal Reflux Disease.- 40 Achalasia.- 41 Esophageal Perforations and Caustic Injuries in Children.- 42 Esophageal Replacement.- Part VI Gastrointestinal.- 43 Infantile Hypertrophic Pyloric Stenosis.- 44 Gastrostomy and Jejunostomy.- 45 Duodenal Obstruction.- 46 Intestinal Malrotation.- 47 Jejuno-Ileal Atresia.- 48 Meconium Ileus.- 49 Duplications of the Alimentary Tract.- 50 Necrotizing Enterocolitis.- 51 Constipation.- 52 Hirschsprung’s Disease .- 53 Variant Hirschsprung’s Disease.- 54 Anorectal Anomalies.- 55 Appendicitis.- 56 Intussusception.- 57 Omphalomesenteric Duct Remnants.- 58 Hernias.- 59 Short Bowel Syndrome.- 60 Inflammatory bowel disease.- 61 Paediatric Small Bowel Transplantation .- Part VII Liver, Biliary Tract and Pancreas.- 62 Biliary Atresia.- 63 Choledochal Cyst.- 64 Hepatic Cysts and Abscesses.- 65 Portal Hypertension.- 66 Gallbladder Disease.- 67 Pancreatic Disorders.- 68 Splenic Disorders.- 69 Pediatric Liver Transplantation.- Part VIII Anterior Abdominal Wall Defects.- 70 Omphalocele and Gastroschisis.- 71 Bladder Exstrophy.- 72 Cloacal Exstrophy.- 73 Prune Belly Syndrome.- 74 Conjoined Twins.- Part IX Tumors.- 75 Vascular Anomalies .- 76 Congenital Nevi.- 77 Lymphatic Malformations.- 78 Sacrococcygeal Teratoma.- 79 Neuroblastoma.- 80 Wilms’ Tumor.- 81 Soft Tissue Sarcoma.- 82 Hepatic Tumors in Childhood.- 83 Lymphomas.- 84 Ovarian Tumors .- 85 Testis Tumors.- Part X Spina Bifida and Hydrocephalus.- 86 Spina Bifida and Encephalocoele.- 87 Hydrocephalus.- 88 Dermal Sinus and Tethered Cord.- Part XI Genitourinary.- 89 Urinary Tract Infection.- 90 Imaging of the Paediatric Urogenital Tract.- 91 Management of Prenatal Hydronephrosis.- 92 Upper Urinary Tract Obstructions.- 93 Ureteric Duplication Anomalies.- 94 Vesicoureteral Reflux.- 95 Posterior Urethral Valves.- 96 Neuropathic Bladder.- 97 End Stage Renal Disease and Renal Transplantation.- 98 Disorders of Sexual Development.- 99 Cryptorchidism.- 100 Acute Scrotum.- 101 Hypospadias.- 102 Circumcision and Buried Penis.- Part XII Paediatric Gynaecology.- 103 Hydrometrocolpos.- 104 Gynecologic Conditions of Childhood.- Part XIII Long-term Outcomes.- 105 Long-term Outcomes in Pediatric Surgery.
£197.99
Springer Nature Switzerland AG Dorothy Hansine Andersen: The Life and Times of the Pioneering Physician-Scientist Who Identified Cystic Fibrosis
Book SynopsisThis book chronicles the life and accomplishments of Dorothy Hansine Andersen, a pioneering American pathologist and pediatrician who was the first person to define, diagnose, and treat cystic fibrosis.Divided into three parts, the book begins by detailing Anderson’s early life, including being orphaned as an adolescent, her college career, and her laborious start in the medical field. Part II then examines Andersen’s role in defining the new disease “cystic fibrosis of the pancreas” and her career of active engagement in various clinical pursuits and research, both in pathology and pediatrics. Chapters in this section also discuss the numerous attempts made by others to minimize Andersen’s work through gender bias and the Matilda Effect. The book concludes by reviewing the foundations laid for CF, Andersen’s legacy, and her terminal illness. Featuring an engaging narrative style, Dorothy Hansine Andersen is a historically relevant, invaluable text for anyone interested in the life of Dorothy Anderson and the nascence of cystic fibrosis diagnoses.Table of ContentsTable of Contents:Introduction Part I: Life before Babies Hospital Chapter 1: A beginning Chapter 2: Orphaned Chapter 3: College and medical school Chapter 4: False start Chapter 5: A reboot Part II: Babies Hospital during the McIntosh Era Chapter 6: Historical perspectives Chapter 7: Synergy Chapter 8: Andy’s abandoned farm Chapter 9: Scoring the first goal Chapter 10: CF firsts Chapter 11: “To Dr. Andersen who has pulled me through many a tough year” Chapter 12: McIntosh, pediatric pathology, and Columbia University Chapter 13: CF sweat and the Matilda Effect Chapter 14: Glycogen storage diseases Chapter 15: Celiac disease Chapter 16: Randomized, controlled trials Chapter 17: Babies Hospital siblings Chapter 18: A last decade of CF research Chapter 19: Pediatric heart diseases Part III: Beyond Babies Hospital and the McIntosh Era Chapter 20: Time to enjoy the view Chapter 21: A foundation and a club for CF Chapter 22: The end of an era Chapter 23: Cancer Afterword
£33.24
Springer International Publishing AG Colorectal Liver Metastasis
a huge range and FREE tracked UK delivery on ALL orders.
£113.99
Springer International Publishing AG Nuclear Medicine in Endocrine Disorders: Diagnosis and Therapy
Book SynopsisThis book presents up-to-date information on the general principles of diagnostic and therapeutic nuclear medicine in the context of endocrinology. The content is divided into six parts. Section I examines general aspects of radiopharmaceuticals, scintigraphy, single-photon emission computed tomography (SPECT), positron emission tomography (PET), radionuclide therapies and radioguided surgery. Section II discusses diagnostic applications in benign thyroid diseases and evaluation of thyroid nodules. Section III gives an overview of the management of parathyroid diseases. Section IV presents diagnostic techniques in well-differentiated thyroid cancer. Section V addresses procedures and therapy in adrenal benign and malignant disorders (phaechromocytomas and paragangliomas). Lastly, the diagnosis and treatment of neuroendocrine tumors are featured in Section VI. Nuclear Medicine in Endocrine Disorders: Diagnosis and Therapy is intended for non-specialists in nuclear medicine working in the field of endocrinology, and is also a valuable resource for researchers and students.Table of Contents1. Radiopharmaceuticals Definitions 2. Principles of Scintigraphies 3. Principles of Single Photon Emission Tomography 4. Principles of Positron Emission Tomography 5. Principles of Nuclear Medicine Therapies 6. Diagnostic Nuclear Medicine in Hyperparathyroidism 7. Diagnostic Nuclear Medicine in Hyperthyroidism 8. Diagnostic Nuclear Medicine in Well Differentiated Thyroid Cancer 9. Diagnostic Nuclear Medicine in Medullary Thyroid Carcinoma 10. Diagnostic Nuclear Medicine in Pheochromocytomas and Paragangliomas 11. Diagnostic Nuclear Medicine in Pulmonary, Intestinal and Pancreatic Neuroendocrine Tumors 12. Diagnostic Nuclear Medicine in Parathyroid Carcinomas 13. Diagnostic Nuclear Medicine in Multiple Endocrine Neoplasia Syndromes 14. Therapeutic Nuclear Medicine in Hyperthyroidism 15. Therapeutic Nuclear Medicine in Well Differentiated Thyroid Cancer 16. Therapeutic Nuclear Medicine in Pheochromocytomas and Paragangliomas 17. Therapeutic Nuclear Medicine in Pulmonary, Intestinal and Pancreatic Neuroendocrine Tumors 18. Intraoperative Radioguided Localization of Parathyroids 19. Intraoperative Radioguided Localization of Sentinel Node in Thyroid Cancer
£61.74
Springer The Diabetes Textbook
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£113.99
Springer International Publishing AG Von HippelLindau Disease
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£33.24
Springer International Publishing AG The MassGeneral Hospital for Children Adolescent Medicine Handbook
Book SynopsisThe second edition of this definitive guide for clinical care of adolescents builds upon the practical knowledge and guidance of the first edition, and expands into new subjects of adolescent care. The handbook is divided into three sections: general adolescent medicine, sexuality, and mental health, and contains relevant, practical knowledge, covering those areas most often seen in the practice of adolescent medicine.The MassGeneral Hospital for Children Adolescent Medicine Handbook, 2nd edition details best practices in regards to diagnostic evaluations and clinical care, but also instructs practitioners on the best methods to connect, communicate, and continue that care with adolescents, in order to provide optimal treatment, and instill healthy lifetime behaviors. Each chapter is written by clinicians who have been trained at, or are members of the staff of Massachusetts General Hospital, and this edition has nearly doubled the amount of skilled physician authors. While this title has been revised and updated, entirely new chapters devoted to hypertension, immunizations, breast disorders, HIV, and resilience have also been added, reflecting new and changing contributions to the field of adolescent medicine. This second edition brings together the practical, hands-on knowledge of the first edition, along with new information and additional subject areas to create a balanced, multi-specialty method to treating and engaging adolescent patients.Trade Review“In 29 chapters and 3 parts the authors, members of the staff of Mass General Hospital (MGH) or its trainees, review the physical and mental health issues in adolescence including sexuality. … There are many tables and illustrations, some in color. Clearly written. To pediatric interns, residents and practitioners. Highly recommended.” (Pediatric Endocrinology Reviews (PER), Vol. 14 (4), June, 2017)“The purpose is to provide primary care providers in all medical and surgical specialties who may care for adolescents with an overview of the basic, most frequent topics encountered in adolescent medicine. … The author has done a great job in meeting these objectives and this is a needed handbook for primary care providers. … This is an excellent resource for busy primary care providers who need a broad overview of the most commonly encountered adolescent medicine topics.” (Rachel Dawson, Doody’s Book Reviews, June, 2017)Table of ContentsPreface AcknowledgementsPART 1. GENERAL ADOLESCENT MEDICINE1. Adolescent Preventive Services 2. The Adolescent Patient Interview: Adolescent Confidentiality and Consent3. Pubertal Development4. Normal Adolescent Development 5. Male Genitourinary Exam6. The Pelvic Examination and Pap Smear in Adolescents and Young Adults7. Adolescent Dermatology 8. Obesity 9. Nutrition: Healthy Eating in Adolescence; Nutritional Supplements: Performance-Enhancing Drugs, and Dietary Supplements; Irritable Bowel Syndrome; and Inflammatory Bowel Syndrome10. Sports Injuries in the Adolescent11. Cardiac Issues in Adolescence 12. Hypertension in Adolescents13. ImmunizationsPART 2. SEXUALITY, GYNECOLOGY, AND ABNORMAL GROWTH AND DEVELOPMENT14. Amenorrhea15. Abnormal Vaginal Bleeding16. Basics of Hormonal Contraception17. Adolescent Pregnancy18. Polycystic Ovary Syndrome 19. Breast Disorders in Adolescence20. Sexually Transmitted Infections (STI) in Adolescents 21. HIV in Adolescents22. Delayed Puberty, Short Stature, and Tall StaturePART 3. MENTAL HEALTH AND TRANSITION OF CARE23. Adolescent Substance Use and Prevention 24. Adolescent Mental Health Disorders25. Eating Disorders26. Adolescent Relationship Abuse in Clinical Settings: Opportunities for Prevention and Intervention27. Bullying and Cyber Bullying 28. Nature, Nurture, Adolescents and Resilience29. Transition of Care APPENDIX
£58.49
Springer International Publishing AG Whole Person Care: Transforming Healthcare
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Wiley-VCH Verlag GmbH Medical Product Regulatory Affairs:
Book SynopsisMedical Product Regulatory Affairs Hands-on guide through the jungle of medical regulatory affairs for every professional involved in bringing new products to market Based on a module prepared by the authors for an MSc course offered by the University of Limerick, Ireland, Medical Product Regulatory Affairs is a comprehensive and practical guide on how pharmaceutical and medical devices are regulated within the major global markets. The Second Edition builds on the success of the first with an even wider scope and full coverage of new EU regulations on the safe use of medical devices. Following a look at drug development, complete sections are devoted to national and EU regulatory issues, manufacturing license application and retention, and regulation in the USA. Other topics dealt with include CDER, CBER and marketing and manufacturing licenses, the ICH process and Good Laboratory/Clinical/ Manufacturing Practices. Medical Product Regulatory Affairs includes information on: Aims and structure of regulation, covering purpose and principles of regulation, national and EU legislative processes, and pharmacopeia Regulatory strategy, covering product development and manufacturing, market vigilance, quality assurance systems, personnel, and documentation Drug discovery and development, covering prescription status, physical properties, therapeutic use, and drug discovery, development, and delivery Non-clinical studies, covering non-clinical study objectives and timing, pharmacological and pharmacodynamic studies, and bioavailability and bioequivalence Clinical trials, covering trial protocol, monitoring of trials, trial master files, and FDA communications The wide coverage of different product types and the main global markets makes Medical Product Regulatory Affairs ideal for training courses on regulatory affairs in academia and industry. It is also a valuable reference for pharmacologists, bioengineers, pharma engineers, and students in pharmacy to familiarize themselves with the topic.Table of Contents1 The Aims and Structure of Regulations 1 1.1 Introduction 1 1.2 Purpose and Principles of Regulation 1 1.3 The Legal Framework for Regulation 3 1.3.1 National Legislative Process 3 1.3.2 EU Legislative Process 4 1.3.3 Working with Legal Texts 6 1.3.4 Guidance Documents 7 1.3.5 Pharmacopoeia 7 1.4 Basic Legislation 7 1.4.1 EU Legislation 7 1.4.2 US Legislation 12 1.5 Scope of the Legislation 15 1.6 Chapter Review 20 1.7 Further Reading 21 2 Regulatory Strategy 23 2.1 Chapter Introduction 23 2.2 Basic Regulatory Strategy 23 2.2.1 Product Development 23 2.2.2 Product Manufacture 23 2.2.3 Market Vigilance 24 2.3 Quality Assurance Systems 25 2.3.1 Personnel 25 2.3.2 Documentation 25 2.3.3 Facilities and Equipment 26 2.3.4 Corrective and Preventative Action 27 2.4 Validation 27 2.5 Regulatory Bodies 29 2.5.1 European Commission 29 2.5.2 The EMA 30 2.5.3 National Competent Authorities 32 2.5.4 Notified Bodies 34 2.5.5 The FDA 35 2.5.6 US Department of Agriculture (USDA) 39 2.5.7 Pharmacopoeia Authorities 39 2.6 International Harmonisation Bodies 40 2.7 International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use 41 2.7.1 VICH 43 2.7.2 The International Medical Device Regulators Forum (IMDRF) 43 2.8 Pharmaceutical Inspection Cooperation Scheme (PICS) 44 2.9 The World Health Organisation (WHO) 45 2.10 Chapter Review 45 2.11 Further Reading 46 3 Drug Discovery, Classification and Early Stage Development 47 3.1 Chapter Introduction 47 3.2 Drug Categorisation 47 3.2.1 Prescription Status 47 3.2.2 Physical Properties 48 3.2.3 Mode of Action 48 3.2.4 Therapeutic Use 49 3.3 Drug Discovery 51 3.3.1 Target Discovery and Validation 52 3.3.2 Lead Discovery, Validation and Optimisation 57 3.4 Drug Development 58 3.4.1 Manufacture and Control 59 3.5 Drug Delivery 59 3.5.1 Location 60 3.5.2 Drug Characteristics 60 3.5.3 Speed and Duration of Therapeutic Effect 62 3.5.4 Stability 63 3.6 Chapter Review 63 3.7 Further Reading 63 4 Non-clinical Studies 65 4.1 Chapter Introduction 65 4.2 Non-clinical Study Objectives and Timing 65 4.3 Pharmacological Studies 69 4.3.1 Pharmacodynamic Studies 70 4.3.2 Pharmacokinetic/Toxicokinetic Studies 72 4.4 Bioavailability and Bioequivalence 73 4.5 Toxicology Studies 74 4.5.1 Toxicity Studies 74 4.5.2 Genotoxicity Studies 75 4.5.3 Carcinogenicity Studies 76 4.5.4 Reproductive Toxicology Studies 76 4.6 Chemistry, Manufacturing and Control Development (CMC) 77 4.7 Quality by Design (QbD) 77 4.8 Quality of Biotech Products 78 4.8.1 Stability Studies 78 4.9 Good Laboratory Practice (GLP) 78 4.10 Chapter Review 80 4.11 Further Reading 83 5 Clinical Trials 85 5.1 Chapter Introduction 85 5.2 Clinical Trials 85 5.2.1 Phase I Trials 86 5.2.2 Phase II Trials 86 5.2.3 Phase III Trials 87 5.3 Clinical Trial Design 88 5.4 Good Clinical Practice 90 5.5 Clinical Trials in the EU 90 5.5.1 Sponsor 93 5.5.2 Investigator’s Brochure (IB) 93 5.5.3 Investigator 94 5.5.4 Trial Protocol 94 5.5.5 Investigational Medicinal Product Dossier (IMPD) 94 5.5.6 Informed Consent 94 5.5.7 Manufacture of Investigational Medicinal Product 95 5.5.8 Clinical Trial Authorisation 95 5.5.9 Independent Ethics Committee Opinion 96 5.5.10 Amendments to Clinical Trials 97 5.5.11 Case Report Forms (CRFs) 97 5.5.12 Adverse Event Reporting 97 5.5.13 Annual Safety Report 98 5.5.14 Monitoring of Trials 98 5.5.15 End of Trial 98 5.5.16 Trial Master File 98 5.6 Clinical Trials in the US 100 5.6.1 Investigational New Drug Application (IND) 100 5.6.2 Institutional Review Board (IRB) 103 5.6.3 Communication with the FDA 104 5.6.4 Labelling of Investigational Drugs 105 5.6.5 Registry of Clinical Trial Information 105 5.7 Chapter Review 105 5.8 Further Reading 106 6 Marketing Authorisation 109 6.1 Chapter Introduction 109 6.2 The Application Dossier 109 6.3 CTD 110 6.3.1 Module Structure 112 6.3.2 Module 3 – Quality 113 6.3.3 Drug Master Files 116 6.3.4 Module 4 – Non-clinical Study Reports 116 6.3.5 Module 5 – Clinical Study Reports 116 6.3.6 Module 2 – Summaries 118 6.3.7 Module I – Region Specific 120 6.3.8 Module 1 – EU 121 6.3.9 Module 1 – US 123 6.4 Submission and Review Process in the EU 127 6.4.1 Union Authorisation 128 6.4.2 Scientific Evaluation Process 129 6.4.3 Decision Making Process 130 6.4.4 National Authorisations 132 6.4.5 Decentralised Procedure 132 6.4.6 Mutual Recognition Procedure 134 6.4.7 Plasma Master Files and Vaccine Antigen Master Files 134 6.5 Submission and Review Process in the US 134 6.6 Chapter Review 138 6.7 Further Reading 138 7 Authorisation of Veterinary Medicines 139 7.1 Chapter Introduction 139 7.2 Overview of Development Process for Veterinary Medicines 139 7.2.1 Pre-clinical Studies 140 7.2.2 Clinical Trials 141 7.2.3 Good Clinical Practices 141 7.3 Authorisation of Clinical Trials in the EU 145 7.4 Authorisation of Clinical Trials in the US 146 7.5 Maximum Residue Limits (MRLs) 147 7.6 Authorisation of Veterinary Medicines in the EU 149 7.6.1 Applications to Establish MRLs 149 7.6.2 Review of Applications and Establishment of MRLs 152 7.6.3 Marketing Authorisations 156 7.6.4 Presentation of the Dossier 156 7.7 Approval of Veterinary Medicines in the US 158 7.7.1 New Animal Drug Application (NADA) 158 7.7.2 Approval of Veterinary Biological Products 163 7.8 Chapter Review 164 7.9 Further Reading 164 8 Variations to the Drug Authorisation Process 165 8.1 Chapter Introduction 165 8.2 Provisions in Support of Special Drug Applications 165 8.2.1 Orphan Drugs 165 8.2.2 Paediatric Applications 167 8.3 Accelerated Access to New Drug Therapies 170 8.3.1 EMA Accelerated Review and Conditional Marketing Routes 170 8.3.2 EU Compassionate Use 171 8.3.3 Expedited Pathways in the US 171 8.3.4 Expanded Access and Emergency Use Authorization (EUA) 174 8.4 Approval of New Drugs When Human Efficacy Studies Are Not Ethical or Feasible 175 8.5 Animal Drugs for Minor Use and Minor Species 176 8.5.1 Conditional Approval 176 8.5.2 Indexing 176 8.5.3 Designation 176 8.6 Special Provisions to Facilitate Access to Drugs for Animal Treatment in the EU 177 8.7 Changes to an Authorised Drug 177 8.8 EU System for Processing Changes 177 8.8.1 Extension Applications 178 8.8.2 Major Variation (Type II) 178 8.8.3 Minor Variation (Type IA or IB) 179 8.9 Processing Changes in the US 179 8.9.1 Manufacturing Change Supplements 180 8.9.2 Major Changes 180 8.9.3 Moderate Changes 180 8.9.4 Minor Changes 181 8.10 Authorisation of Generic Drugs 181 8.10.1 EU Regulations 181 8.10.2 US Regulations 182 8.11 Biosimilars 183 8.11.1 EU Regulations 184 8.11.2 US Regulations 185 8.12 Reference Drug Exclusivity 189 8.13 Other Authorisation Procedures 191 8.13.1 Well-Established Medical Use Products 191 8.13.2 Combination Products 191 8.13.3 Homeopathic Medicines 192 8.13.4 Traditional Herbal Medicines 192 8.13.5 US Regulation of OTC Drugs 193 8.14 Chapter Review 193 8.15 Further Reading 194 9 Medical Devices 195 9.1 Chapter Introduction 195 9.2 Regulatory Strategy for Medical Devices in the EU 195 9.2.1 Use of Standards to Establish Conformity 200 9.2.2 Classification of Devices 201 9.3 Regulatory Strategy for Medical Devices in the US 210 9.3.1 Classification of Devices 210 9.3.1.1 Class I 211 9.3.1.2 Class II 211 9.3.1.3 Class III 211 9.3.2 Classification of New Devices 212 9.4 Development of Devices 212 9.4.1 Design Controls 213 9.4.2 Design and Development Planning 214 9.4.3 Design Input 214 9.4.4 Design Output 216 9.4.5 Design Verification and Design Validation 216 9.4.6 Design Review 217 9.4.7 Risk Analysis 218 9.4.8 Design Changes 218 9.5 Chapter Review 218 9.6 Further Reading 219 10 Authorisation of Medical Devices 221 10.1 Chapter Introduction 221 10.2 Evaluation of Medical Devices in Europe 221 10.2.1 Clinical Evaluation 221 10.2.2 Clinical Investigations 222 10.2.3 Performance Evaluation of IVDs 225 10.2.4 Performance Studies of IVDs 225 10.3 Evaluation of Medical Devices in the US 226 10.3.1 Exempted Investigations 227 10.3.2 Abbreviated Requirement Investigations 227 10.3.3 IDE Investigations 227 10.3.4 Labelling of Devices for Investigational Use 229 10.4 Placing of Devices on the Market in the EU 230 10.4.1 Designation of Notified Bodies 230 10.4.2 Conformity Assessment Procedures 232 10.4.2.1 Conformity Assessment Based on a Quality Management System and Assessment of Technical Documentation 233 10.4.2.2 EU Type-Examination 235 10.4.2.3 Production Quality Assurance 235 10.4.2.4 EU Verification 235 10.4.2.5 EU (Self) Declaration of Conformity 236 10.4.3 Technical Documentation 236 10.4.4 Labelling Requirements 236 10.4.5 Registration of Economic Operators and Devices 238 10.5 Placing of Devices on the Market in the US 238 10.5.1 510(k) Pre-market Notification 239 10.5.2 Traditional 510(k) 239 10.5.3 Abbreviated 510(k) 239 10.5.4 Special 510(k) 239 10.5.5 De Novo 510(k) 240 10.5.6 Notification and Review Procedures 240 10.5.7 Pre-market Approval (PMA) 240 10.5.8 Changes to a PMA-Approved Device 241 10.5.9 Humanitarian Use Devices (HUDs) 243 10.5.10 Labelling of Devices 243 10.6 Chapter Review 243 10.7 Further Reading 244 11 Good Manufacturing Practice (GMP) 245 11.1 Chapter Introduction 245 11.2 Drug GMP Regulations and Guidance 245 11.3 Essential GMP Requirements 248 11.3.1 Quality Assurance System 248 11.3.2 Personnel 248 11.3.3 Premises and Equipment 249 11.3.4 Documentation 257 11.3.5 Production 257 11.3.6 Quality Control 258 11.3.7 Work Contracted Out 259 11.3.8 Complaints, Product Recall and Emergency Un-blinding 259 11.3.9 Self-inspection 259 11.4 Validation 260 11.4.1 Facilities and Equipment Validation 261 11.4.2 Process Validation 262 11.4.3 Computer Systems Validation 262 11.4.4 Methods Validation 265 11.4.5 Cleaning Validation 266 11.4.6 Validation of Sterilisation Procedures 267 11.4.7 Water Purification System Validation 268 11.5 GMP Requirements for Devices 268 11.6 Chapter Review 273 11.7 Further Reading 273 12 Oversight and Vigilance 275 12.1 Chapter Introduction 275 12.2 Registration of Manufacturers and Other Entities 275 12.3 Manufacturing Authorisation of Medicinal Products in the EU 275 12.3.1 Wholesale Distribution of Medicinal Products 276 12.3.2 Registration of Economic Operators for Medical Devices on the EU market 278 12.4 Registration of Producers of Drugs and Devices in the US 278 12.5 Additional Licensing Requirements 279 12.6 Inspections 279 12.6.1 Inspection Techniques 280 12.6.2 Audit Findings and Consequences 286 12.7 Market Vigilance and Oversight of Drugs 289 12.7.1 Pharmacovigilance in the EU 289 12.7.2 Pharmacovigilance Risk Assessment Committee (PRAC) and the EudraVigilance System 290 12.7.3 Pharmacovigilance and Marketing Authorisation Holders 293 12.7.4 Pharmacovigilance Inspections and Audits 294 12.7.5 Renewal of Marketing Authorisations 295 12.7.6 Pharmacovigilance and Reporting in the US 295 12.7.7 Periodic Reports 296 12.8 Advertising and Promotion 297 12.9 Market Vigilance and Oversight of Devices 298 12.9.1 Market Vigilance in the EU 298 12.9.2 Medical Device Vigilance in the US 299 12.9.3 Medical Device Reporting 299 12.9.4 Reports of Corrections and Removals 300 12.9.5 Post-market Surveillance 302 12.10 Chapter Review 303 12.11 Further Reading 303 Index 305
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Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Geriatrics 2: Digestive System · Endocrine System Kidney and Urogenital System Haematological System · Respiratory System Rehabilitation · Nutrition · Drug Treatment
Table of ContentsDigestive System.- The Upper Gastrointestinal Tract. Esophagus, Stomach, Small Bowel, and Exocrine Pancreas.- A. Manifestations of Gastrointestinal Disease in the Aged.- B. Esophagus.- I. The Aging Esophagus.- II. Symptoms.- 1. Dysphagia.- 2. Pain.- 3. Heartburn.- 4. Bleeding.- 5. Impaction.- III. Diagnostic Modalities.- 1. Radiography.- 2. Esophagoscopy.- 3. Manometry.- 4. Acid Drip Test.- 5. Tests of Reflux, pH Probe, and Radioisotopic Scintigrams.- IV. Diseases of the Esophagus.- 1. Motility Disturbances of the Oropharynx and Upper Esophagus.- 2. Motility Disorders of the Middle and Lower Esophagus.- a) Achalasia.- b) Diffuse Spasm.- c) Collagen Vascular Disease.- d) Diabetes Mellitus.- 3. Reflux Esophagitis, Hiatus Hernia, and Barrett’s Epithelium.- 4. Paraesophageal Hiatus Hernia.- 5. Lower Esophageal Rings.- 6. Infection of the Esophagus.- 7. Tumors of the Esophagus.- C. Stomach and Duodenum.- I. Anatomy and Physiology of the Aging Stomach.- II. Diagnostic Modalities.- 1. Radiography.- 2. Endoscopy.- 3. Gastric Analysis.- 4. Serum Gastrin.- III. Diseases of the Stomach and Duodenum.- 1. Functional Disease.- 2. Peptic Ulcer.- 3. Gastritis and Duodenitis.- 4. Bezoars.- 5. Tumors.- D. Small Intestine.- I. The Aging Small Intestine.- II. Diagnostic Modalities.- 1. X-ray.- 2. Tests of Malassimilation.- III. Diarrhea.- IV. Diseases of the Small Bowel.- 1. Regional Granulomatous Enteritis.- 2. Vascular Diseases.- 3. Maldigestion due to Gastric Surgery.- 4. Disaccharidase Deficiencies.- 5. Gluten-Sensitive Enteropathy.- 6. Bacterial Overgrowth Syndromes.- 7. Systemic Diseases Involving the Small Intestine.- 8. Malabsorption due to Drug Ingestion.- 9. Immunologic Deficiency Associated with Malabsorption.- 10. Whipple’s Disease.- 11. Short Bowel Syndrome.- 12. Tumors.- a) Adenocarcinoma.- b) Lymphoma.- c) Leiomyosarcortia.- d) Premalignant Lesions.- e) Carcinoid Tumors.- f) Benign Tumors.- g) Telangiectasia and Angiodysplasia.- E. Exocrine Pancreas.- I. The Aging Pancreas.- II. Diagnostic Modalities.- 1. Radiography.- 2. Endoscopic Retrograde Pancreatography.- 3. Function Tests.- III. Diseases.- 1. Acute Pancreatitis.- 2. Chronic Pancreatitis.- 3. Tumors.- a) Adenocarcinoma.- b) Islet Cell Tumors.- c) Benign Tumors.- References.- The Large Intestine.- A. The Anatomy and Physiology of the Aging Large Intestine.- B. Diagnostic Modalities.- I. Radiography.- II. Endoscopy.- III. Fecal Examination.- C. Diseases of the Large Intestine.- I. Functional Bowel Disorders.- 1. Irritable Bowel Syndrome.- 2. Constipation.- 3. Incontinence.- II. Diverticular Disease.- III. Appendicitis.- IV. Vascular Insufficiency.- V. Vascular Ectasia.- VI. Infectious Disease.- 1. Bacteria.- 2. Parasites.- VII. Inflammatory Bowel Disease.- 1. Ulcerative Colitis.- 2. Crohn’s Colitis.- VIII. Colorectal Cancer.- IX. Benign Tumors.- References.- The Liver and Biliary System.- A. Liver.- I. Physiological Aging.- 1. Anatomical Changes.- 2. Functional Changes.- a) Biochemical Changes.- b) Enzymatic Changes.- c) Hepatic Drug Metabolism in Old Age.- d) Changes in Liver Function Tests.- e) Bile Formation and Composition.- II. Diseases of the Liver in Old Age.- 1. Clinical Evaluation.- a) Biochemical Investigation.- b) Immunological Tests.- c) Haematology.- d) Radiology of the Hepatobiliary System.- e) Endoscopy.- f) Liver Biopsy.- g) Liver Imaging.- 2. Jaundice in Old Age.- a) Unconjugated (Prehepatic) Hyperbilirubinaemia.- b) Conjugated (Hepatic or Posthepatic) Hyperbilirubinaemia.- 3. Circulatory Disturbances.- a) Acute (Heart Failure, Shock).- b) Chronic Heart Failure.- c) Hepatic Vein Occlusion.- 4. Toxic Liver Injury.- a) Hepatic Necrosis.- b) Fatty Liver.- c) Hepatitis-like Reaction.- d) Intrahepatic Cholestasis.- 5. Inflammatory Diseases.- a) Viral Hepatitis.- b) Cholangitis.- c) Liver Abscess.- d) Chronic Inflammations.- 6. Cirrhosis.- a) Classification.- b) Incidence and Mortality.- c) Aetiology.- 7. Liver Failure.- 8. Infiltrations of the Liver.- a) Malignant Disease.- b) Amyloidosis.- 9. The Liver in Systemic Disorders.- a) Diabetes Mellitus.- b) Chronic Bowel Inflammation.- c) Collagen Diseases.- B. Biliary System.- I. Physiological Aging.- 1. Anatomical Changes.- 2. Functional Changes.- II. Disease of the Biliary System.- 1. Clinical Evaluation.- 2. Gallstones.- a) Clinical Features and Associations.- b) Silent Gallstones.- c) Medical Treatment of Gallstones.- d) Gallstones in the Common Bile Duct.- e) Gallstone Ileus.- 3. Cholecystitis.- a) Acute Cholecystitis.- b) Chronic Cholecystitis.- 4. Malignant Disease.- a) Carcinoma of Gallbladder.- b) Carcinoma of the Bile Ducts.- References.- Endocrine System.- Hypothalamo-Hypophyseal-Adrenal Axis.- A. Introduction.- I. Adaptation to Stress, Such as Surgery.- II. Hypothalamic-Pituitary-Adrenal Interrelationships.- B. Morphology.- I. Hypothalamus.- II. Pituitary.- III. Adrenal.- C. Basal Function.- I. Hypothalamus.- II. Pituitary.- III. Adrenal Cortex.- 1. Glucocorticoids.- 2. Mineralocorticoids.- 3. Androgens.- IV. Adrenal Medulla.- D. Dynamic Function.- I. Insulin Tolerance Test.- II. Metyrapone Test.- III. Dexamethasone Suppression Test.- IV. ACTH Test.- V. Surgery.- E. Clinical.- I. Anterior Pituitary.- II. Posterior Pituitary.- III. Adrenal Cortex.- IV. Adrenal Medulla.- V. Ectopic Humoral Syndromes.- VI. Iatrogenic Disease.- F. Conclusions.- References.- The Aged Thyroid Gland.- A. Morphology of the Elderly Thyroid.- B. Physiology of the Aged Thyroid.- I. Iodine Metabolism.- II. Thyroid Hormones.- III. Binding Proteins.- IV. Regulation by the Hypothalamic Anterior Pituitary System.- C. Nontoxic Goiter.- D. Hypothyroidism in Elderly Subjects.- I. Myxedema Coma.- E. Hyperthyroidism in Elderly Subjects.- F. Endocrine Ophthalmopathy.- G. Thyroiditis.- H. Struma Maligna.- I. Laboratory Diagnosis of Thyroid Diseases in Geriatric Patients.- I. TSH and theTRH-TSH Test.- II. Total Serum Thyroxine Concentration, Free Thyroxine, Binding Proteins, and Parameters for Determination of Free T4.- III. Total Triiodothyronine, Free T3, and Thyroid Antibodies.- IV. In Vivo Diagnostic Techniques.- References.- Diabetes Mellitus in Advanced Age.- A. Definition and Classification.- I. Primary Diabetes Mellitus.- II. Secondary Diabetes Mellitus.- III. Subclinical Diabetes Mellitus.- B. Epidemiology of Maturity Onset Diabetes.- C. Etiology and Pathogenesis.- D. Pathophysiology.- E. Diagnosis.- F. Diabetes Therapy in Advanced Age.- I. Dietary Measures.- II. Muscular Exercise in the Elderly Diabetic Patient.- III. Oral Antidiabetic Agents.- 1. Sulfonyl Ureas.- 2. Biguanides.- IV. Insulinization of the Maturity Onset Diabetic.- G. Acute Complications.- I. Coma Diabeticum.- II. Hypoglycemia.- H. Chronic Complications.- I. Diabetic Macroangiopathy.- II. Pyelonephritis.- III. Diabetic Neuropathy.- I. Prognosis.- References.- Sexual Function During Advancing Age.- A. Anatomic and Physiologic Considerations.- B. Totality of Factors in Human Sexuality.- C. Male Psychogenic Impotency.- D. Organic Basis of Impotency.- I. Systemic Illness.- II. Neurologic Deficit.- III. Vascular Problems.- IV. Chronic Hemodialysis.- V. Malignancy.- VI. Cosmetic Factors.- VII. Postoperative Impact.- VIII. Drugs.- E. Methods of Diagnosis of Sexual Impotency.- I. Clinical Acuity of Interviewer.- II. Testing Techniques: Mechanical Aids.- F. Therapy of Male Impotency.- I. Counseling.- II. Prosthetic Devices.- G. Therapy of Female Sexual Dysfunction.- H. Concluding Remarks.- References.- Kidney and Urogenital System.- The Kidney.- A. Characteristic Features of Geriatric Nephrology.- B. Aging of the Kidney.- I. Structural Changes.- 1. Loss of Nephrons.- 2. Glomerular Changes.- 3. Tubular Changes.- 4. Vascular Changes.- 5. Renal Hypertrophy.- II. Functional Changes.- 1. Renal Plasma Flow.- 2. Glomerular Filtration.- 3. Tubular Function.- 4. Fluid and Electrolyte Balance.- C. Disease of the Kidney - Geriatric Aspects.- I. Renovascular Disease.- II. Pyelonephritis and Urinary Tract Infection.- 1. Bacteriuria and Pyelonephritis.- 2. Predisposing Factors.- 3. Urosepsis.- 4. Treatment of Urinary Tract Infection in the Aged.- 5. Resistance Problems in Geriatric Wards.- 6. Treatment of Patients with Indwelling Catheters.- 7. Prognostic Significance of Bacteriuria.- III. Acute Glomerulonephritis.- IV. Nephrotic Syndrome.- V. Other Renal Diseases.- D. Uraemia.- I. Acute Renal Failure.- II. Chronic Renal Failure.- III. Treatment of the Uraemic Elderly Patient.- References.- Bladder and Prostate.- A. Bladder.- I. Embryological Origins.- II. Anatomy.- III. Nerve Supply.- IV. The Functioning Bladder.- V. Symptoms Associated with Bladder Dysfunction.- B. Special Diagnostic Methods.- I. The Cystometrogram.- II. Peak Flow Rate.- III. Micturating Cystogram.- IV. Urethral Pressure Profile.- V. Cystoscopy.- C. Prostate Gland.- I. Anatomy.- II. Benign Enlargement of the Prostate.- III. The Pathology of Prostatic Obstruction.- IV. Symptoms.- V. Diagnosis.- VI. Treatment.- D. Prostatic Carcinoma.- I. Symptoms.- II. Diagnosis.- III. Treatment.- E. Prostatitis.- I. Acute Prostatitis.- II. Chronic Prostatitis.- F. Carcinoma of the Bladder.- I. Pathological Staging.- II. Diagnosis.- III. Treatment.- G. Retention of Urine.- I. Causes.- II. Treatment.- H. Cystitis.- I. Causes.- II. Treatment.- I. Incontinence of Urine.- I. Causes.- II. Clinical Examination of the Incontinent Patient.- III. Treatment.- J. Drug Therapy in Incontinence.- References.- Haematological System.- Blood in the Aged.- A. Ageing of Bone Marrow.- B. Red Blood Cells.- I. Erythrocytes in the Aged.- II. Ageing of Erythrocytes.- III. Erythropoiesis in the Aged.- IV. Haemoglobin.- C. White Blood Cells.- I. General Aspects.- II. Granulocytes.- III. Monocytes.- IV. The Regulation of Granulocyte-Monocyte Production.- V. Lymphocytes and Lymphatic System.- D. Anaemias in the Aged.- I. Introduction.- II. Carential Anaemias.- 1. Iron Deficiency Anaemias.- 2. Megaloblastic Anaemias.- a) Pernicious Anaemia.- b) Folic Acid Deficiency Anaemia.- 3. Other Macrocytic, Non-Megaloblastic Anaemias.- 4. Therapy of Carential Anaemias in the Aged.- III. Haemolytic Anaemias.- IV. Aplastic Anaemias and Pancytopenias.- V. Anaemias Due to Chronic Diseases.- VI. Sideroblastic Anaemias.- E. Disorders of Leucocytes in the Aged.- I. Idiopathic Granulocytic Dysfunction.- II. Neutropenia (Agranulocytosis).- III. Leukaemias and Allied Disorders.- 1. Acute Leukaemias.- 2. Chronic Myelocytic Leukaemia.- 3. Chronic Lymphocytic Leukaemia.- 4. Malignant Lymphomas.- a) Non-Hodgkin’s Malignant Lymphomas.- b) Hodgkin’s Disease.- 5. Monoclonal Gammapathies.- a) Myeloma.- b) Waldenstrom Macroglobulinaemia.- 6. Miscellaneous Conditions.- a) Polycythaemia Rubra Vera.- b) Myelofibrosis.- c) Idiopathic Thrombocythaemia.- F. Disorders of Haemostasis in the Aged.- I. Blood Coagulation and Haemostasis in the Aged.- II. Haemorrhagic Diseases in the Aged.- 1. Congenital Hereditary Haemorrhagic Diseases.- 2. Acquired Haemorrhagic Diseases.- a) Acquired Coagulation Disorders.- b) Thrombocytopenias.- c) Haemorrhagic Syndromes Due to Intervascular Coagulation.- d) Haemorrhagic Syndromes Due to Vascular Factors.- e) Bateman’s Purpura.- III. Thrombosis and Thrombo-Embolic Diseases in the Aged.- 1. Pathogenesis of Thrombophilia.- 2. Diagnostic Problems in Thrombophilia.- 3. Prophylaxis of Thrombophilic States.- 4. Thrombolytic Therapy.- References.- Respiratory System.- Physiological and Pathological Aspects of the Respiratory System.- A. Changes in Structure of the Lungs with Age.- I. Changes in the Alveoli.- II. Changes in Pulmonary Blood Vessels.- B. Changes in Lung Function with Age.- I. Elasticity and Distensibility of the Lungs.- II. Lung Volume.- III. Airway Closure and Distribution of Ventilation.- IV. Ventilation Perfusion Matching: Blood Gases.- V. Gas Transfer.- VI. Exercise.- C. The Appearance of the Chest Radiograph in Old Age.- D. Infection of the Respiratory Tract in Old Age.- I. Upper Respiratory Tract Infection.- II. Influenza.- III. Pneumonia.- IV. Unresolved Pneumonia.- V. Tuberculosis.- E. Conditions Associated with Airways Obstruction.- I. Chronic Bronchitis and Emphysema.- II. Asthma.- III. Obstruction of Large Airways.- F. Cancer of the Lung.- G. Pulmonary Fibrosis and Alveolitis.- I. Cryptogenic Fibrosing Alveolitis.- II. Extrinsic Allergic Alveolitis.- References.- Rehabilitation.- Rehabilitation - Physical and Clinical Aspects.- A. Definition.- B. The Importance of Geriatric Rehabilitation.- C. Legislative Background and Costs.- D. Biological Factors Governing Rehabilitation in Old Age.- I. Physiological Characteristics of Senescence: Diminished Adaptive Capacity and Exaggerated Interindividual Variation.- 1. Methods and Indices for Assessing Physical Capacity in Old Age.- II. Pathophysiological Characteristics: Variation of Clinical Symptoms Typical of Ageing and Multimorbidity; Extent and Consequences.- III. Exercise Tolerance and the Demands of Training.- IV. The Response to Training in Old Age.- V. Methods of Training for Elderly Handicapped Patients.- E. Indications for Rehabilitation in Old Age.- I. General Principles.- II. Assessment of the Need for Rehabilitation.- III. Assessment of the Potential Response to Rehabilitation.- IV. Criteria Which Exclude Rehabilitation.- F. Resources and Methods of Geriatric Rehabilitation.- I. Human Resources: The Rehabilitation Team.- 1. The Geriatrician.- 2. Physiotherapy.- 3. Occupational Therapy.- a) Mobile Occupational Therapy.- 4. Logopedia.- 5. Physical Medicine.- 6. Social Work.- 7. Psychology.- 8. Activating Care.- II. Institutional Resources: Rehabilitation Centers.- 1. Part-time Inpatient Care: The Geriatric Day Clinic.- 2. Inpatient Facilities.- a) The Geriatric Rehabilitation Clinic and the Department of Geriatric Rehabilitation.- b) The Long-Stay Hospital and the Old People’s Home with Rehabilitation Facilities.- III. Ambulant Rehabilitation Measures.- 1. Measures Governed by Local Facilities.- a) The Human Resources.- b) The Material Resources.- 2. Measures Governed by the Patient’s Circumstances.- IV. Other Therapeutic Ancillary Facilities at the Service of Geriatric Rehabilitation.- 1. The Depot of Medical and Self-help Aids.- 2. Social Services and District Nurses.- V. Other Aids and Supporting Services: Meals on Wheels, Shopping Services, and Sheltered Workshops.- G. The Practical Implementation of Geriatric Rehabilitation as Exemplified by Rehabilitation Hospital Procedures.- I. Initial Measures (Early Phase, Bedside Therapy).- II. Indoor Walking Phase.- III. Concluding Phase with Outdoor Therapy.- IV. Transition, Aftercare, and Reintegration.- H. Results of Geriatric Rehabilitation Measures.- References.- Nutrition.- Nutritional Characteristics of the Elderly.- A. Introduction.- B. Physiological Changes Influencing Nutrition.- I. Changes in Body Size and Composition.- II. Energy Expenditure.- III. Metabolism.- IV. Digestion.- C. Requirements of Essential Nutrients.- I. Protein and Essential Amino Acids.- 1. Protein.- 2. Essential Amino Acids.- II. Vitamins.- 1. Vitamin B6.- 2. Vitamin C.- 3. Vitamin D.- III. Minerals.- 1. Iron.- 2. Calcium.- D. Food Consumption and Nutritional Status of the Elderly.- E. Conclusions.- References.- The Role of Nutrition in Human Aging.- A. Introduction.- B. Multifactorial Nature of the Aging Process.- I. Physical Performance.- II. Changes in Energy Metabolism.- III. Lipid Metabolism and the Cardiovascular System.- IV. Nervous System and Sensory Changes.- V. Hormonal Changes.- VI. Kidney Changes.- VII. Skeletal Changes.- VIII. Skin Changes.- IX. Gastrointestinal Tract Changes.- X. Generalization.- C. Degenerative Diseases and Diet.- I. Common Dietary Restrictions.- II. Health Foods.- III. Generalizations.- D. Significance of Diet.- I. Nutrition Survey Evidence.- II. Population Differences.- III. Economic Effects.- IV. Transplanted Populations.- V. Diet and Cancer.- VI. Generalization.- E. Importance of Diet Components.- I. Crude Fiber.- II. Minerals.- III. Lipids.- IV. Trace Components.- V. Generalization.- F. Experience from Surveys and Feeding Programs.- I. Survey Data.- II. Feeding Programs.- III. Economic Considerations.- IV. Generalizations.- G. Conclusions.- References.- Protein and Amino Acid Metabolism and Nutrition During Human Aging.- A. Introduction.- B. Some Aspects of Body Composition in Relation to Aging.- C. Whole Body and Muscle Protein Metabolism.- D. Metabolism of Specific Proteins.- E. Status of Amino Acid Metabolism.- F. Protein and Amino Acid Requirements.- I. Requirements for Essential Amino Acids.- II. Requirement for Total Nitrogen (Protein).- G. Effects of Infection and Other Stressful Stimuli on Protein Metabolism and Requirements.- H. Summary.- References.- Vitamins and the Aging Process.- A. Introduction.- B. Definition.- C. Functions of Vitamins.- D. Some Aspects of Utilization of the Vitamins.- E. Vitamin Status of the Elderly.- F. Methods for Estimating the Vitamin Requirements in Adults.- G. Factors Affecting Vitamin Requirements in Elderly People.- H. Summary and Conclusions.- References.- Human Aging and Obesity.- A. Introduction.- B. The Relationship of Age and Obesity.- C. Effects upon Blood Pressure of Change in Weight Status from Childhood to Adult Life.- D. The Relationship Between Obesity, Mortality, and Coronary Heart Disease.- E. The Treatment of Obesity.- References.- Drug Treatment.- Drug Treatment in the Aged.- A. Introduction.- B. Pharmacokinetics.- I. Absorption.- II. Distribution.- 1. Plasma Proteins.- 2. Erythrocytes.- 3. Tissue Composition.- III. Metabolism.- IV. Excretion.- 1. Kidneys.- 2. Liver.- V. Side Effects.- 1. Glycosides.- 2. Diuretics.- 3. Antihypertensives.- 4. Analgesics.- 5. Anticoagulants.- 6. Sedatives.- 7. Antiparkinsonism Drugs.- 8. Antidepressive Drugs.- C. General Principles of Drug Therapy.- D. Drugs to Combat Ageing.- References.
£85.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Malformations
Table of ContentsVesicoureteral Reflux.- A. Definition of Reflux.- B. Anatomy of the Ureterovesical Junction.- I. Contribution of the Ureter and Trigone to the Formation of the Ureterovesical Junction.- II. The Vesical Component of the Ureterovesical Valve.- 1. The Mucosal Layer.- 2. The Inner Longitudinal Muscle Layer.- 3. The Middle Circular Muscle Layer.- 4. The Outer Longitudinal Muscle Layer.- C. Innervation.- D. Physiology of the Ureterovesical Valve.- I. The Effect of Interrupting the Anatomical Continuity between the Ureter and the Trigone.- II. The Effect of Cutting the Nerves that Supply the Trigonal Muscle.- III. The Effect of Active Contraction of the Trigone on the Resistance of the Intravesical Ureter.- IV. The Effect of Active Contraction of the Trigone in Tightening and Occluding the Intravesical Ureter during Voiding.- E. Pathology of the Ureterovesical Junction.- I. Structural Changes at the Ureterovesical Junction.- 1. Conditions in which the Ureteral Hiatus Moves Downward in Relationship to the Ureteral Orifice.- 2. Conditions in which the Ureteral Orifice Moves Upward in Relation to the Ureteral Hiatus.- II. The Effect of Vesical Edema on the Ureterovesical Junction.- III. Congenital Anomalies of the Ureter.- IV. Maturation of the Intravesical Ureter.- V. Concept of the Marginally Competent Ureterovesical Junction.- F. Classification of Reflux by Etiology.- I. Reflux Due to Trigonal Weakness.- II. Reflux Due to Obstruction at or below the Bladder Neck.- III. Reflux Due to Neurogenic Vesical Disease.- IV. Reflux Due to Edema of the Bladder Wall.- V. Reflux Due to Congenital Anomalies.- VI. Reflux Due to Iatrogenic Causes.- G. Etiology of Nonocclusive Ureteral Dilatation (Megaloureter).- I. Factors that Increase the Volume of Urine in the Ureter.- 1. Dilation of the Renal Pelvis and Ureter by Forced Intake of Fluids.- 2. Dilation of the Upper Urinary Tract Due to Diabetes Insipidus.- 3. Dilation of the Pelvis of a Kidney Forced to Increase its Output after Unilateral Nephrectomy.- 4. Reflux as a Cause of Ureteral Overfilling.- II. Emptying Capacity of Various Areas of the Ureter.- III. Reflux and the Ureteropelvic Junction.- IV. Reflux and the Ureterovesical Junction.- H. Incidence of Reflux.- I. High Incidence of Reflux in Children with Urinary Tract Infection.- II. Demonstration of Reflux in Adults with Nonobstructive Pyelonephritis.- I. Effects of Reflux.- I. The Role of Reflux in Obstruction at the Ureteropelvic Junction.- II. The Kidney with Chronic Pyelonephritis.- III. The Atrophic Kidney with Chronic Pyelonephritis.- IV. The Normal Kidney.- V. Reflux as the Cause of Pyelonephritis of Pregnancy.- VI. Role of Reflux in the Perpetuation of Urinary Tract Infection.- VII. Miscellaneous.- J. The Role of the Ureterovesical Junction in the Pathogenesis of Pyelonephritis.- I. Childhood.- II. The Teenage Period.- III. The Adult Period.- IV. Prostatic Period.- K. The Treatment of Reflux and its Complications.- I. Medical Treatment.- II. The Surgical Correction of Reflux.- 1. Types of Operation.- 2. Results of Operation.- 3. Indications for Operation.- a) The Severity of the Reflux.- b) The Presence of Saccules.- c) The Severity of the Clinical Course.- d) The Conditions of the Kidneys.- e) The Age of the Patient.- References.- Anomalies of the Kidney.- I. Agenesis.- a) Bilateral Renal Agenesis.- b) Solitary Pelvic Kidney.- II. Hypoplasia.- a) Unilateral.- b) Bilateral.- III. Cystic Disease.- a) Simple (Solitary) Cysts.- b) Multiple Cysts of the Kidney.- c) Multilocular Cysts.- d) Polycystic Kidney Disease.- e) Peripelvic Cysts.- IV. Fusion Anomalies of the Kidney.- a) Horseshoe Kidney.- b) Unilateral Fused Kidney.- c) Fused Pelvic Kidney.- V. Ectopia of the Kidney.- 1. Introduction.- 2. Classification.- a) Simple Ectopy.- b) Bilateral Ectopia.- c) Crossed Renal Ectopia.- d) Ectopic Pelvic Kidney.- e) Thoracic Kidney (Congenital Superior Ectopia).- VI. Anomalies of Rotation.- 1. Introduction.- 2. Embryology.- 3. Incidence.- 4. Etiology.- 5. Symptoms and Diagnosis.- 6. Treatment.- VII. Anomalies of the Vessels.- 1. Introduction.- 2. Production of Hydronephrosis by Aberrant Vessels.- 3. Incidence.- 4. Symptoms.- 5. Diagnosis.- 6. Treatment.- VIII. Supernumerary Kidney.- 1. Introduction and Incidence.- 2. Pathogenesis.- 3. Symptoms.- 4. Diagnosis.- 5. Treatment.- IX. Cystic Disease of the Renal Pyramids.- 1. Definition and Historical.- 2. Incidence.- 3. Etiology.- 4. Pathology.- 5. Clinical Considerations.- 6. Diagnosis.- 7. Treatment.- 8. Prognosis.- X. Anomalies of the Renal Pelvis.- 1. Incidence.- 2. Embryological Development.- 3. Clinical Considerations.- 4. Differential Diagnosis.- 5. Treatment.- Acknowledgments.- References.- Anomalies of the Ureter.- A. Multiplication, Ectopia and Ureterocele.- I. Ureteral Duplication (and Triplication).- 1. Definitions.- 2. Incidence (Table 1).- 3. Embryology and Physiology.- a) Embryology.- b) Physiology.- 4. Surgical Anatomy.- 5. Associated Anomalies.- 6. Associated Reflux.- 7. Associated Disease.- 8. Clinical Aspects.- a) Symptoms.- b) Diagnosis.- ?) Personal History.- ?) Family History.- ?) Physical Examination.- ?) Laboratory Study of the Urine.- ?) Excretory Urography.- ?) Cystoscopy.- ?) Vaginoscopy and Urethroscopy.- ?) Other Radiographic Techniques.- c) Principles of Management.- ?) Incomplete Ureteral Duplication.- ?) Complete Ureteral Duplication.- ?) Triplication or Quadruplication.- II. Ureteral Ectopia.- 1. Definition and Description.- 2. Sites of Ectopic Orifices.- 3. Incidence.- 4. Associated Anomalies.- 5. Clinical Features.- a) Incontinence.- b) Obstruction and Dilatation.- c) Infection.- 6. Diagnosis.- a) History.- b) Family History.- c) Physical Examination.- d) Urinalysis.- e) Urographie Procedures.- ?) Excretory Urography.- ?) Micturition Urethrocystography.- ?) Vasography.- f) Endoscopy.- 7. Treatment.- III. Ureterocele.- 1. Definition, Description, Types.- 2. Incidence.- 3. Pathogenesis.- 4. Associated Anomalies and Disease.- 5. Clinical Manifestations.- 6. Reflux.- 7. Diagnosis.- a) Urography.- ?) Excretory Urography.- ?) Retrograde Urethrocystography.- b) Endoscopy.- 8. Treatment.- a) Simple Ureterocele.- b) Ectopic Ureterocele.- B. Ureteropelvic Junction Obstruction.- 1. Definition and Description.- 2. Incidence.- 3. Causes.- a) Aberrant Renal Blood Vessels.- b) Adhesions and Kinks.- c) High Insertion of Ureter.- d) Stenosis.- e) Functional Disorders.- f) Vesicoureteral Reflux.- 4. Clinical Aspects.- a) Superimposed Intermittent Acute Obstruction.- b) Recurrent Pyelonephritis with Loin Pain.- c) Renal Calculi.- d) Hematuria.- e) Trauma.- f) Associated Hypertension.- 5. Diagnosis.- 6. Treatment.- C. Unusual Positions of the Ureter.- I. Retrocaval (Post-caval; Circumcaval) Ureter.- 1. Definition.- 2. Incidence.- 3. Embryology.- 4. Clinical Aspects.- a) Symptoms and Signs.- b) Diagnosis.- c) Treatment.- II. Retroiliac Ureter.- III. Herniation of the Ureter.- D. Agenesis, Aplasia, Blind Ending.- I. Agenesis.- II. Aplasia.- III. Blind Ending Ureters.- E. Congenital Dilatation of the Ureter.- I. With Obstruction.- 1. Congenital Ureteral Stricture.- 2. Distal Ureteral Atresia.- 3. Congenital Ureteral Valves (or Folds).- II. Without Obstruction.- F. Twists, Kinks, Congenital Diverticula, Blockage by Vessels.- I. Spiral Twist or Torsion of Ureter.- II. Ureteral Kinks.- III. Diverticulum of the Ureter.- IV. Blockage of the Ureter by Blood Vessels.- References.- Congenital Abnormalities of the Bladder.- A. Development of the Bladder.- I. The Cloaca.- II. The Genital Tubercle.- III. Separation of the Bladder from the Intestinal Tract.- IV. Formation of the Trigone.- V. Regression of the Allantoic Duct.- VI. Development of the Bladder Musculature.- VII. Fetal Descent of the Urinary Tract.- VIII. Summary of Important Early Developmental Events.- B. Congenital Abnormalities of the Bladder.- I. Agenesis of the Bladder.- 1. Incidence.- 2. Pathology.- 3. Treatment.- II. Urachal Abnormalities.- 1. Incidence.- 2. Pathology.- 3. Classification.- 4. Clinical features.- a) Congenital Patent Urachus.- b) Vesico-urachal Diverticulum.- c) Umbilical Cyst and Sinus.- d) Alternating Urachal Sinus.- 5. Treatment.- III. Duplication of the Bladder.- 1. Classification.- a) Complete Duplication.- b) Incomplete Duplication.- c) Sagittal Septum.- d) Frontal Septum.- e) Multiseptate Bladder.- f) Hourglass Bladder.- 2. Pathology.- 3. Clinical Features.- 4. Diagnosis.- 5. Treatment.- IV. Bladder Mucosal Redundancy (Trigonal Curtains).- 1. Clinical Features.- 2. Treatment.- V. Congenital Cyst of the Bladder.- 1. Clinical Features.- 2. Pathology.- 3. Diagnosis and Treatment.- VI. Congenital Bladder Diverticulum.- 1. Incidence.- 2. Etiology.- 3. Pathology.- 4. Diagnosis.- 5. Treatment.- VII. The Exstrophy-epispadias Complex.- 1. Pathology.- 2. Pseudo-exstrophy of the Bladder.- 3. Classical Exstrophy of the Bladder.- a) Pathology.- b) Anatomy.- c) Clinical Features.- d) Treatment.- ?) Urinary Diversion.- ?) Functional Closure of Exstrophy.- 4. Cloacal Exstrophy.- a) Pathology.- b) Anatomy and Clinical Features.- c) Treatment.- 5. Variants of Exstrophy.- a) Superior Vesical Fissure.- b) Duplicate Exstrophy.- c) Inferior Vesical Fissure.- d) Incomplete Cloacal Exstrophy.- 6. Epispadias.- a) Pathology.- b) Description.- ?) Balanic Type.- ?) Penile Type.- ?) Penopubic Type.- c) Clinical Features.- d) Treatment.- References.- Anomalies of the Bladder Neck.- Anomalies of the Bladder Neck.- Symptoms.- Diagnosis.- The Normal Bladder Neck.- Technique.- Cinefluorographic Appearance of Normal Bladder Outlets During Micturition.- Dilatation of the Urethra Distal to Wide Bladder Necks.- Bladder Neck Dysfunction.- Errors in Diagnosis and Management.- The Roentgen Appearance of the Normal Male Bladder Neck.- Bladder Neck Dysfunction in the Male.- Bladder Neck Dysfunction Accompanying Posterior Urethral Valves.- Summary.- References.- Anomalies of the Urethra.- I. Introduction.- II. Congenital Absence of the Urethra.- 1. Complete Absence of the Urethra.- 2. Obliteration at the Level of the Bladder Neck.- 3. Obliteration at the Level of the Membranous Urethra.- 4. Obliteration of the Penile Urethra.- III. Meatal Stenosis.- IV. Distal Urethral Stenosis.- V. Congenital Urethral Stricture.- VI. Congenital Valves of the Female Urethra.- VII. Congenital Hypertrophy of the Verumontanum.- VIII. Anterior Urethral Valves.- IX. Diverticula of the Anterior Urethra.- 1. Incidence.- 2. Etiology and Pathology.- 3. Clinical Presentation and Diagnosis.- 4. Treatment and Prognosis.- X. Double Urethra and Accessory Urethra.- 1. Complete Double Urethra.- 2. Incomplete Dorsal Accessory Urethra—blind.- 3. Incomplete Dorsal Accessory Urethra—Communicating with the Urethra.- 4. Incomplete Ventral Accessory Urethra—blind.- 5. Double Urethra in the Female.- XI. Posterior Urethral Valves.- 1. Incidence.- 2. Etiology and Pathology.- 3. Clinical Presentation.- 4. Diagnosis.- 5. Treatment.- 6. Prognosis.- References.- Anomalies of the Male Genitalia.- A. The Undescended Testicle.- I. Causes.- II. Associated Conditions.- III. Differential Diagnosis.- IV. Method of Examination.- V. Medical Treatment.- VI. Surgical Treatment.- 1. Indications.- 2. Surgical Anatomy.- 3. Surgical Principles.- 4. Technique.- 5. Special Situations.- 6. Other Methods.- 7. Results.- B. Other Abnormalities of the Testicle.- Anorchism and Hypoplasia.- C. Appendages of the Testicle, Epididymis and Cord.- D. Anomalies of the Tunics of the Testicle and Scrotum.- E. Epididymis.- F. Vas Deferens.- G. Prostate.- H. Seminal Vesicles.- References.- Hypospadias.- Embryology and Morphology.- Incidence.- Female Hypospadias.- Therapeutic Principles.- Techniques for Correction of Chordec.- Position of New Meatus.- Basic Types of Urethroplasty.- General Results.- Personal Experiences.- Complications.- References.- Anomalies of the Female Genitalia.- I. Anomalies of the Vulva and Vagina.- 1. Reduplication of the Vulva.- 2. Masculinization of the Vulva.- 3. Imperforate Hymen.- 4. Polyps of the Hymen.- 5. Transverse Vaginal Septum.- II. Anomalies of the Mullerian Ducts.- 1. Congenital Absence of the Vagina and Uterus.- 2. Maldevelopment of the Vagina and Uterus.- a) Obstructive Maldevelopment of the Vagina and Uterus.- b) Non-obstructive Maldevelopment of the Vagina and Uterus.- III. Anomalies of the Ovary.- 1. Congenital Absence of the Ovaries.- 2. Supernumerary Ovaries.- 3. Accessory Ovaries.- 4. Displaced Ovaries.- References.- The Intersex States.- I. Criteria of Sex.- 1. The Sex Chromatin and Sex Chromosomes.- 2. Gonadal Structure.- 3. Morphology of External Genitalia.- 4. Morphology of the Internal Genitalia.- 5. Hormonal Status.- 6. Gender Role.- II. The Definition and Classification of Hermaphroditism.- III. Ovarian Agenesis and Dysgenesis.- 1. The Pathology of Gonadal Agenesis.- 2. The Diagnosis in Newborn Infants.- 3. The Diagnosis in Adolescence.- 4. Endocrine Findings.- IV. True Hermaphroditism.- 1. General Considerations.- 2. Criteria for Diagnosis.- 3. Classification of True Hermaphroditism.- 4. Clinical Features.- 5. Sex Chromosome Complements.- 6. Principles of Treatment.- V. Klinefelter’s Syndrome.- 1. Clinical Characteristics.- 2. Laboratory Findings.- 3. Pathological and Cytogenetic Findings.- 4. Treatment.- VI. Double X Males.- VII. Multiple X Syndromes.- VIII. Female Hermaphroditism Due to Congential Adrenal Hyperplasia.- 1. Clinical Considerations.- 2. Adrenal Pathology.- 3. Ovary.- 4. Developmental Anomalies of the Genital Tubercle and Urogenital Sinus Derivatives.- 5. Hormonal Changes.- 6. Pathogenesis of Virilizing Adrenal Hyperplasia.- 7. Diagnosis.- 8. Treatment.- IX. Female Hermaphroditism without Progressive Masculinization.- 1. Classification.- 2. Maternal Ingestion of Androgen.- 3. Maternal Androgen Tumor.- 4. Idiopathic.- 5. Special or Non-Specific Female Hermaphroditism.- X. Male Hermaphroditism.- 1. General Considerations.- 2. Classification.- 3. Masculinizing Male Hermaphrodites.- 4. Asymmetrical Gonadal Differentiation.- 5. Feminizing Male Hermaphrodites (Testicular Feminization Syndrome).- 6. Sex Chromosomes in Male Hermaphroditism.- XI. Differential Diagnosis of Infants with Ambiguous Genitalia.- XII. The Treatment of Hermaphroditism.- 1. General Considerations.- 2. The Construction of Female External Genitalia.- References.- Author Index.
£40.49
Editorial Academica Espanola Lactancia Materna: Iniciativa IHAN
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Springer Verlag, Japan Hepatitis C Virus I: Cellular and Molecular Virology
Book SynopsisThis volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the “top 10 papers” published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.Table of ContentsPart I. Hepatitis C Virus.- 1. Towards the Control of Hepatitis C (Michael Houghton).- 2. Hepatitis C Virus Genotypes and Their Evolution (Tadasu Shin-I, Masaya Sugiyama, Masashi Mizokami).- 3. The Structure of HCV (Joseph Marcotrigiano and Maria Teresa Catanese).- Part II. The Viral Life Cycle.- 4. Cell Culture Systems for Propagation of HCV.- 5. HCV Receptors and Virus Entry (Rajiv G. Tawar, Catherine Schuster, and Thomas F. Baumert).- 6. Structural Proteins of HCV and Biological Functions (Kohji Moriishi and Yoshiharu Matsuura).- 7. Role of Nonstructural Proteins in HCV Replication (Tetsuro Suzuki and Ryosuke Suzuki).- 8. The HCV Replicase Complex and Viral RNA Synthesis (Inés Romero Brey and Volker Lohmann).- 9. Host factors and the HCV lifecycle (Glenn Randall).- 10. Lipid Peroxidation and Hepatitis C Virus Replication (Daisuke Yamane and Stanley M. Lemon).- 11. Lipid and Lipoprotein Components Play Important Roles in HCV Egress and Infectivity (Takayuki Hishiki, Yuko Shimizu, Saneyuki Ujino, Hironori Nishitsuji, and Kunitada Shimotohno).- Part III. Immune Recognition and Pathogenesis.- 12. New Animal Models for Hepatitis C (Alex Ploss).- 13. Innate Immune Recognition of Hepatitis C Virus (Kui Li).- 14. B Cell Responses and Control of HCV Infection (Zhen-Yong Keck, Thomas R. Fuerst, Roy A. Mariuzza, and Steven K.H. Foung).
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£27.55
Jaypee Brothers Medical Publishers A Comprehensive Handbook of IVF
Book SynopsisIn vitro fertilisation (IVF) is one of several techniques available to help people with fertility problems have a baby. During IVF, an egg is removed from the woman''s ovaries and fertilised with sperm in a laboratory. The fertilised egg, called an embryo, is then returned to the woman''s womb to grow and develop.This book is a complete guide to IVF for specialists and trainees in reproductive medicine.Divided into two parts, the first sections discuss clinical aspects of IVF, including laboratory set-up, patient selection and preparation, drugs and stimulation protocols, male infertility, the operating theatre and assisted reproductive technology (ART) techniques, special situations such as endometriosis and recurrent implantation failure; and recent advances in ART.The second part of the book covers laboratory aspects, explaining the physical and practical processes of IVF including management of culture conditions, quality control, male and female gametes, embryo gradation and implantation, cryopreservation and sperm freezing, and advanced embryology.With a recognised, international team of authors, this comprehensive text is further enhanced by diagrams and figures to assist learning. Table of ContentsPART A: IVF CLINICAL ASPECTS SECTION 1: STEPPING UP IN IN VITRO FERTILIZATION SECTION 2: DRUGS AND STIMULATION PROTOCOLS IN IN VITRO FERTILIZATION SECTION 3: MALE INFERTILITY SECTION 4: IN VITRO FERTILIZATION OPERATION THEATER AND TECHNIQUES IN ASSISTED REPRODUCTIVE TECHNOLOGY SECTION 5: SPECIAL SITUATIONS IN IN VITRO FERTILIZATION SECTION 6: LET'S LEARN SOMETHING DIFFERENT PART B: IVF LABORATORY ASPECTS (HANDS ON EMBRYOLOGY) SECTION 7 BUILDING UP THE CULTURE AMBIENCE SECTION 8 KNOW YOUR CULTURE CONDITIONS SECTION 9 HANDLING THE MALE GAMETE SECTION 10 THE BOSS: FEMALE GAMETE SECTION 11 OOCYTE/EMBRYO GRADATION SYSTEMS SECTION 12 OOCYTE, EMBRYO, AND IMPLANTATION SECTION 13 FROZEN LIFE SECTION 14 ADVANCED TECHNIQUES: EMBRYOLOGY ADD-ONS SECTION 15 THE EMBRYOLOGIST
£59.85
Jaypee Brothers Medical Publishers Aravind FAQs in Ophthalmology
Book SynopsisThis book is a compilation of frequently asked questions (FAQs) with answers to help students prepare for postgraduate ophthalmology examinations. The third edition, comprising more than 1200 pages, has been fully revised to provide students with the latest information and advances in the field. Answers to questions have been meticulously refined in line with current concepts and knowledge. Divided into fourteen sections, the book begins with an introduction, followed by numerous questions for each part of the eye. As well as exam-oriented questions, the text also features a management summary of commonly kept examination cases and examples of case sheet writing. The final section provides an ophthalmology question bank to assist students with revision and test their understanding. The previous edition (9789386261090) published in 2018.Table of Contents Introduction Cornea Uvea Glaucoma Lens and Cataract Retina Neuro-ophthalmology Orbit Pediatric Ophthalmology and Strabismus Optics and Refraction Miscellaneous Management Summary of Commonly Kept Examination Cases Case Sheet Writing Ophthalmology Question Bank Index
£31.35
Jaypee Brothers Medical Publishers Tips Tricks in Interventional Cardiology
Book SynopsisThis new edition has been fully revised to provide clinicians with the latest advances in interventional cardiology, focusing on key procedures used in practice. Beginning with an overview of percutaneous coronary intervention (PCI), the following sections discuss imaging techniques (IVUS and OCT), instruments such as stents, and techniques for different cardiovascular disorders. A complete chapter is dedicated to drugs used in the catheterisation lab and mechanical circulatory support. The book concludes with discussion on structural and congenital heart disease, and complications of PCI. The third edition has been expanded and includes new topics and features numerous clinical photographs, diagrams and tables. The previous edition (9789352700875) published in 2017.
£36.10
Jaypee Brothers Medical Publishers Retina Atlas
Book SynopsisThis atlas provides ophthalmologists with a collection of images to help with the identification, diagnosis and subsequent treatment of retinal disorders.The images are procured from Eidon scanner technology and also include optical coherence tomography (OCT) pictures to assist with understanding of related pathologies.Divided into nine sections, the book begins with images illustrating the normal fundus. Each of the following sections covers a different retinal disorder including diabetic retinopathy, macula disorders, retinal detachment, ocular tumours and hereditary diseases.Each section features a multitude of images, each with brief descriptive text to assist understanding.The second edition of this illustrative atlas has been fully revised and updated to reflect the latest developments and knowledge in the field.Previous edition (97893895874432) published in 2020.
£80.75
Jaypee Brothers Medical Publishers Hypertension
Book SynopsisHypertensionis another name for high blood pressure. It can lead to severe complications and increases the risk of heart disease, stroke, and death. Blood pressure is the force exerted by the blood against the walls of the blood vessels. This book is a comprehensive guide to the diagnosis and management of high blood pressure. Divided into three sections, the text begins with an overview of the condition, current guidelines on its management, potential organ damage, and nonpharmacological treatments. The next section covers the management of hypertension with associated disorders such as diabetes, cardiovascular disease, stroke, kidney disease, and more. A complete chapter is dedicated to white coat' hypertension. The final section discusses management approaches when initial treatment fails, and hypertensive emergencies. Each chapter is presented as a case scenario, describing prevention, diagnosis, previous control attempts, challenges, and treatments, both pharmalogical and nonpharmalogical. This second edition has been fully revised and updated to provide clinicians and trainees with the latest advances and knowledge in the field. A number of new topics have also been included. Authored by experts from the University of South Carolina, the text is further enhanced by clinical images, figures and tables. The previous edition (9789386261489) published in 2019.
£69.21
Jaypee Brothers Medical Publishers Color Atlas of Cornea
Book Synopsis
£71.25
Jaypee Brothers Medical Publishers Rapid ECG Interpretation
Book SynopsisThe practical substance of this text is aimed at all doctors who assess, and prescribe for patients with cardiovascular problems. It is for clinicians and residents who wish to interpret ECGs accurately. The arrhythmia chapter is packed with clues for diagnosis and therapy, and practical steps. Presents a unique 11-step method for accurate and rapid ECG interpretations in a user-friendly synopsis format. It is thoroughly revised and updated. Includes the latest updates of ECG interpretation along with its importance in assessments of various abnormalities such as ST-segment elevation and also an addition of chapter on enhancing ECG quality. Provides different diagnostic ECG criteria with relevant and instructive ECGs that act as ready-reckoner for proficiency tests and also helpful for physicians who are preparing for the Cardiovascular Diseases Board Examination. The significant information are presented through a succinct writing style and highlighted with bullets. The practical aspects of the book help the clinicians and senior residents for accurate interpretations of the ECG associated with cardiovascular diseases. Table of Contents1Electrocardiogram Basic Concepts must be Mastered 2New Method for ECG Interpretation 3P Wave Abnormalities 4Bundle Branch Block 5ST Segment Abnormalities, ST segment elevation MI, non ST segment elevation MI 6Q Wave Abnormalities 7Atrial and Ventricular Hypertrophy 8T Wave Abnormalities 9Electrical Axis and Fascicular Blocks 10Miscellaneous Conditions 11Arrhythmias 12ECG Board Self-Assessment Quiz 13New placements of limb lead provide superior quality ECG s.
£32.00
Springer Common Bile Duct Exploration: Intraoperative investigations in biliary tract surgery
Book Synopsis2. Stone extraction via the T-tube 89 3. Endoscopic method 89 4. Preparation for stone extraction 90 5. Technique 90 6. Results 91 7. Complications 91 8. Discussion 91 Index of Subjects 99 CHAPTER 1 INTRODUCTION This book was conceived as a descriptive atlas of most reliable indication for common bile duct ex routine biliary surgery i. e. , cholecystectomy and ploration. The cholangioscope allows a visual ex exploration of the common bile duct. For the pro ploration of the biliary tree and permits the re ject the two authors worked together for one week moval of common bile duct calculi and other as biopsy under direct visual con at Ninewells Hospital and Medical School, Dundee procedures such on a series of patients with biliary tract disease trol. Both procedures have been described in detail especially selected for the exercise. With the con with emphasis on the practical aspects of their use. sent of the Tayside Health Board and the patients The era of blind bilary surgery is over and the concerned, all the operations and peri-operative sooner this message is received by all concerned, procedures were filmed by the photographic mem the better the outcome of biliary surgical practice bers of the team, Mr. and Mrs. Paz-Partlow. Ad overall. ditional case material has been obtained from It has not been our intention to produce a com Cedars Sinai Medical Center, Los Angeles.Trade Review`...excellently illustrated... ...of value to all surgeons performing biliary tract surgery.' Gastrointestinal Endoscopy, 31:5 (1985) `...an easy to read and excellent cooperative project from Scotland and the USA between a surgeon, endoscopist and radiologist. It can be commended to abdominal surgeons and will make a useful contribution to safer cholecystectomy.' Journal of the Royal Society of Medicine, 78 (1985) `...should be of help to all surgeons in training.' British Medical Journal, 219 (1985) Table of Contents1. Introduction.- 2. Review of existing problems in biliary tract surgery.- 3. Surgical approach and principles.- 1. Introduction.- 2. Prophylactic measures.- 2.1. Infectious complications.- 2.2. Haemorrhagic complications.- 2.3. Renal failure.- 3. Pre-operative biliary decompression in the jaundiced patient.- 4. Operative principles.- 4.1. Surgical access.- 4.2. Patient positioning.- 4.3. Appropriate incision.- 4.4. Illumination of the operating field.- 4.5. Packing.- 4.6. Exposure of relevant anatomy.- 5. Drainage of the supracolic compartment after biliary operations.- 4. Operative cholangiography (in cooperation with J.A. Hamlin and M. Paz-Partlow).- 1. Introduction.- 2. Common bile duct explorations.- 3. Unsuspected stones.- 4. Cannulation techniques.- 5. Initial and/or completion cholangiograms.- 6. Standard technique.- 6.1. Technique and equipment.- 6.2. Patient’s positioning.- 6.3. Scout film.- 6.4. Injected volume.- 6.5. Contrast material.- 6.6. Coordination of exposure.- 6.7. Mobile C-arm fluoroscope.- 7. Fluoro-cholangiography.- 7.1. Easy positioning of the patient.- 7.2. Optimal beam collimation.- 7.3. Shorter exposure time.- 7.4. Automatic exposure control.- 7.5. Minimal technician activity.- 7.6. Control of the exposure sequence.- 7.7. Serial films.- 7.8. Decreased examination time.- 7.9. Indirect radiography.- 8. Anomalies of surgical importance.- 8.1. Short cystic duct.- 8.2. Drainage of cystic duct in the right hepatic duct.- 8.3. Aberrant ducts.- 8.4. Ductal diverticula and choledochocele.- 8.5. The acute or emergency case.- 9. General aspects.- 10. Radiation protection.- 11. The cystic duct.- 12. Cholecysto-cholangiogram.- 13. The choledocho-cholangiogram.- 13.1. Direct needle puncture.- 13.2. Butterfly needle puncture.- 13.3. Special needle clamp.- 13.4. T-tube insertion.- 14. Contact selective cholangiography.- 15. Reason for failure for operative cholangiography.- 15.1. Overfilled ducts.- 15.2. Underfilled ducts.- 15.3. Poor quality films.- 15.4. Improper positioning.- 15.5. Obscured field.- 16. Artifacts.- 17. Complications of operative cholangiography.- 18. Reformed calculi.- 19. Complications of T-tube removal in the post-operative period.- 20. Results of operative cholangiography.- 20.1. Advantages.- 20.2. Disadvantages.- 5. Operative biliary endoscopy (cholangioscopy) (in cooperation with M. Paz-Partlow).- 1. Introduction.- 2. Instrumentation.- 2.1. Accessories.- 3. Technique.- 3.1. Mobilization of the duodenum.- 3.2. Endoscopic appearance.- 3.3. The cystic stump remnant.- 4. Endoscopic anatomy and pathology.- 4.1. Normal findings.- 4.2. Cholangitis.- 4.3. Calculi.- 4.4. Ampullary stenosis.- 4.5. Neoplasms.- 4.6. Miscellaneous.- 5. Repeated cholangioscopy.- 6. Complications.- 7. General aspects.- 7.1. Sterilization.- 7.2. Maintenance.- 8. Evaluation of results.- 9. Conclusions.- 6. Biliary manometry and debimetry.- 1. Introduction.- 2. Usage.- 3. Pharmacolgy of the sphincter of Oddi (SO).- 3.1. Effect of hormones and peptides.- 3.2. Effect of pharmacological agents.- 4. Biliary pressure indices.- 4.1. Resting (initial, interdigestive) pressure.- 4.2. Passage (yield, opening) pressure.- 4.3. Filling pressure curves.- 4.4. Residual pressure.- 4.5. Flow rate (debimetry).- 4.6. Incremental pressure and recovery time.- 5. Dynamic (transducer) manometry.- 5.1. Endoscopic sphincter zone activity.- 5.2. Technique of operative biliary manometry.- 6. Disorders of the sphincter of Oddi.- 6.1. Iatrogenic stricture.- 6.2. Papillitis/Oedema.- 6.3. Papillary stenosis (choledocho-duodenal junctional stenosis).- 6.4. Functional disorders.- 7. Exploration of the common bile duct.- 1. Introduction.- 2. Technique of CBD exploration.- 2.1. Mobilization of duodenum and head of pancreas.- 2.2. Exposure of the CBD.- 2.3. Choledochotomy.- 2.4. Cholangioscopy.- 2.5. Additional procedures.- 2.6. Insertion of T-tube.- 2.7. Closure of choledochotomy wound.- 3. Trans-duodenal exploration od CBD.- 4. Intra-hepatic calculi.- 5. Assessment of terminal end of the CBD and sphincteric region.- 6. Post-operative removal of T-tube.- 7. Conclusion.- 8. Postoperative removal of retained stones through the T-Tube tract (in cooperation with J.A. Hamlin).- 1. Introduction.- 2. Stone extraction via the T-tube.- 3. Endoscopic method.- 4. Preparation for stone extraction.- 5. Technique.- 6. Results.- 7. Complications.- 8. Discussion.- Index of Subjects.
£40.49
Springer Transport and Inherited Disease: Monograph based upon Proceedings of the Seventeenth Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisMany clinical problems of transport have been known for decades, par ticularly those disorders involving the liver and kidney. As a result of the dramatic increase in interest in transport at the membrane level the Society devoted its Seventeenth Symposium, held at Leeds during September 1979, to Transport and Inherited Disease, the result of that meeting forming the basis of this monograph. For the occasion over a hundred members and guests of the Society were joined by many invited speakers from Europe and the USA to discuss this rapidly developing field with special reference to the direct interests of the Society - in herited metabolic disease. The major theme of the meeting was opened with formal scientific presentations on membrane structure, synthesis and the regulation of epithelial transport. These were followed by discussions of specific prob lems of transport in brain, kidney and red blood cells. Almost all of these later lectures had clinical applications with cystic fibrosis and nephro genic diabetes insipidus featuring as examples of the common inherited diseases. The Hudson Memorial Lecture was delivered by Professor H. Bickel (Heidelberg). This outstanding review lecture on 'Phenylketonuri- past, present and future' is reproduced in the Journal of the Society - the Journal of Inherited Metabolic Disease (Volume 3 No.4, pp.123-132). xiii xiv PREFACE The members' papers (both oral and poster) are also being reprinted in various issues of the Journal (published by MTP Press Ltd., Lancaster, UK).Table of ContentsSection One.- 1 The inherited methylmalonic acidaemias: a model system for the study of vitamin metabolism and apoenzyme-coenzyme Interactions — The Milner Lecture.- Section Two Biochemistry of Membranes.- 2 Membrane structure.- 3 Synthesis of membranes.- 4 Some regulatory principles in epithelial transport.- Section Three Transport in Brain.- 5 The needs of the brain for amino acids and how they are transported across the blood-brain barrier.- 6 Some aspects of the transport of glucose and ketone bodies into the brain and retina.- Section Four Renal Transport.- 7 The function and organization of kidney microvillar proteins.- 8 Cyclic nucleotides and the regulation of water and electrolyte transport.- 9 Mineralocorticoids and sodium transport.- 10 Sodium transport in cystic fibrosis.- 11 Nephrogenic diabetes insipidus.- 12 Mendelian hypophosphataemias as probes of phosphate and sulphate transport by mammalian kidney (X-linked hypophosphataemia. Autosomal hypophosphataemia in man and Hyp mutation in mouse).- 13 Renal transport of cystine by isolated renal tubules and brush-border membrane vesicles.- 14 5-Oxoprolinuria and other inborn errors related to the ?-glutamyl cycle.- Section Five Transport in Red Blood Cells.- 15 Anion transport in red blood cells.- 16 Inherited disorders of red-cell cation transport.- 17 Red-cell amino acid and nucleoside transport: inherited lesions and related enzyme deficiencies in sheep.
£40.49
Springer Inborn Errors of Metabolism in Humans: Monograph based upon Proceedings of the International Symposium held in Interlaken, Switzerland, September 2–5, 1980
Table of ContentsSection One Pathogenic Mechanisms of Inborn Errors: Clinical Implications of Biochemical Diversity.- 1 Molecular aspects of genetic heterogeneity.- 2 Inborn errors of purine metabolism-The Milner Lecture.- 3 Vitamin-responsive inherited metabolic disorders: propionic acidaemia and methylmalonic acidaemia.- 4 Homocystinuria: clinical and biochemical heterogeneity.- 5 Hereditary defects of steroid biosynthesis.- 6 Blood-brain barrier amino-acid transport: clinical implications.- Section Two Treatment: New Aspects and Limits, Transplantation, Replacement Therapy, Genetic Engineering.- 7 Recent studies on the maturation of lysosomal enzymes.- 8 Enzyme substitution by fibroblast transplantation.- 9 Artificial cell-encapsulated enzymes and adsorbents in congenital metabolic disorders.- 10 Prospects for enzyme replacement therapy in heritable metabolic disorders.- Section Three Inborn Errors of Metabolism affecting Brain Development (Animal Models).- 11 Inborn errors of metabolism affecting brain development-Introduction.- 12 Mutations in mice affecting brain development and their correlations with human diseases.- 13 Murine mutations affecting myelination: models to study myelin diseases in the human.- 14 The effect of phenylalanine on myelin metabolism in adolescent rats.- 15 Abnormal oligodendrocyte differentiation in a mouse mutant with defect in myelination.- Section Four Consequences of Inborn Errors of Metabolism for the Individual, the Family and Society.- 16 Inborn errors of metabolism consequences of long-term treatment for the individual, as derived from observations in phenylketonuria.- 17 Social aspects of the handicapped person.- 18 Psychological and educational aspects of handicap.- 19 Repercussions of screening.- 20 Some principles in the management of inherited metabolic disease.
£40.49
Springer Problems in Arthritis and Rheumatism
Book SynopsisThis series of books is designed to help general practitioners. So are other books. What is unusual in this instance is their collec tive authorship; they are written by specialists working at district general hospitals. The writers derive their own experi ence from a range of cases less highly selected than those on which textbooks are traditionally based. They are also in a good position to pick out topics which they see creating difficulties for the practitioners of their district, whose personal capacities are familiar to them; and to concentrate on contexts where mistakes are most likely to occur. They are all well-accustomed to working in consultation. All the authors write from hospital experience and from the viewpoint of their specialty. There are, therefore, matters important to family practice which should be sought not within this series, but elsewhere. Within the series much practical and useful advice is to be found with which the general practitioner can compare his existing performance and build in new ideas and improved techniques. These books are attractively produced and I recommend them.Table of ContentsSection 1 General Aspects.- 1 Introduction.- Importance of rheumatology in practice.- Classification of rheumatic disorders.- Frequency of rheumatic disorders in family practice.- The outcome and prognosis of rheumatic diseases.- 2 Some illustrative problems.- Ankylosing spondylitis.- Non-steroidal anti-inflammatory drugs.- Pain and paraesthesiae in arms.- The acute back.- The painful foot.- A gouty attack.- The painful hip.- A knee effusion.- Laboratory investigations.- The acute neck.- Helpful organizations.- Polymyalgia rheumatic.- Early rheumatoid arthritis.- The painful shoulder.- Tennis elbow.- 3 Diagnosis and assessment of rheumatic disorders.- Symptoms, signs and their diagnostic significance.- X-rays and laboratory investigations.- Early diagnosis: indications for referral for further opinion.- 4 Effect of the psyche on rheumatism.- Assessment of the ‘psychological overlay’.- Psychological and emotional disturbance: their manifestations in rheumatology.- pure — psychogenic rheumatism.- 5 Basic management of arthritis and rheumatism.- Pain relief.- Disease activity and its reduction.- Improvement of mobility and function.- Analgesics.- Anti-inflammatory drugs.- Practical procedures in family practice.- Physiotherapy.- Occupational therapy and rehabilitation.- Section 2 The Common Rheumatic Disorders.- 6 Soft-tissue (non-articular) rheumatism.- Classification.- Clinical varieties and treatment.- 7 Osteoarthritis.- Aetiology and pathology.- Clinical varieties.- Management in family practice.- Management in hospital.- 8 Rheumatoid arthritis.- Early recognition.- Complications.- Differential diagnosis.- Management of the early case in practice.- Hospital management.- Rheumatoid arthritis in children and the elderly.- 9 Ankylosing spondylitis and seronegative spondarthritis.- Concept of seronegative spondarthritis.- Ankylosing spondylitis.- Clinical features.- Management in practice.- 10 Gout and crystal deposition arthritis.- Crystal deposition arthritis: clinical varieties.- Gout: investigation of patients.- Treatment of gout.- Investigation and treatment of chondrocalcinosis.- Section 3 Regional Pain Syndromes.- 11 Pain in the neck and back.- Common causes of pain.- Investigation of neck pain syndromes.- Treatment of neck pain syndromes.- Investigation of low back pain.- Treatment of low back pain.- 12 Pain syndromes of the upper limb.- Causes of pain.- Diagnosis and treatment of pain.- 13 Pain syndromes of the lower limb.- Causes of pain.- Diagnosis and treatment of pain.- Causes of painful feet.- Section 4 Appendix.- Glossary of rheumatic disorders.- Further reading.
£44.99
Springer Basic and Clinical Hepatology
Book SynopsisThe liver has been an organ of mystery for centuries. Slowly but surely its secrets have been disclosed by both basic research and clinically oriented investigators whose current concepts have been brought together in this book by authors from five different countries. Three major groups with many subgroups have made inroads into our better understanding of the liver. The first of these comprises the basic scientists whose study of single hepatocytes may provide the key to comprehension of mechanisms that will lead eventually to improvement in the morbidity and mortality associated with a variety of hepatic disorders. The second group has been concerned with studies in depth of the liver's response to a variety of hormones, drugs, viruses, and infections. Both early and late results are their concern in the diagnosis and treatment of the individual patient. A third group comprises the surgeons who have become increasingly aggressive in the removal of one or more segments of the liver. They have increased the scope of hepatic resection as a result of a better understanding gained from studies of various segments of the liver. They have accepted the term, segmentectomy, and have extended feasible procedures to include trisegmentectomy. Indeed, trans plantation of the liver has been successfully accomplished.Table of Contents1. Segments of the liver: the anatomical basis for partial hepatectomy.- 2. Fine structure of human liver cells.- 3. Scanning electron microscopy of the mammalian liver.- 4. Freeze-fracture of hepatic fine structure under normal and experimental conditions.- 5. Morphofunctional features of cultured liver cells.- 6. Microcirculation of the liver, with special reference to the peribiliary portal system.- 7. Liver stereology.- 8. Liver physiology and biochemistry.- 9. Electron microscopy in human liver pathology.- 10. Radiology of the liver.- 11. Clinical aspects of modern hepatology.- 12. Trends and developments in hepatic surgery.
£40.49
