Clinical and internal medicine Books

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Book SynopsisThe Royal Marsden is the world's first hospital dedicated to cancer diagnosis, treatment, research and education a centre of excellence with an international reputation for ground-breaking research and pioneering the very latest in cancer treatments and technologies, as well as specialising in cancer diagnosis and education. This companion volume to the internationally successful The Royal Marsden Manual of Clinical Nursing Procedures is designed to support practitioners who work specifically with oncology patients by providing detailed evidence-based procedures and rationale, and problem-solving guidance on all aspects of oncology nursing. The Royal Marsden Manual of Cancer Nursing Procedures: Is organized and structured to represent the needs of the patient along their care pathwayProvides the latest evidence underpinning all proceduresIncludes information on haematological procedures; pain assessment and management; wound care; oncological emergencies; and end-of-life careGivesTable of ContentsForeword xi Acknowledgements xii List of contributors xiii List of abbreviations xv Quick reference to the procedure guidelines xvii How to use your manual xix Introduction xxi 1 Diagnostic investigations 1 Overview 2 Diagnostic tests and investigations 2 Tumour markers 4 Cervical uterine smear 8 Diagnostic radioisotope procedures (nuclear medicine) 12 Transrectal ultrasound (TRUS) prostate biopsy 18 Flexible cystoscopy 24 Breast diagnostics 36 Clinical breast examination 38 Core biopsy 40 Breast fine-needle aspiration (FNA) 43 Breast punch biopsy 45 Nipple discharge smear 47 Genetic testing 48 Websites 52 References 52 Procedure guidelines for Chapter 1 1.1 Cervical uterine smear using liquid-based cytology 9 1.2 Unsealed radioactive sources for diagnostic investigations 16 1.3 Transrectal ultrasound (TRUS) prostate biopsy 21 1.4 Flexible cystoscopy 27 1.5 Flexible cystoscopy with stent removal 30 1.6 Flexible cystoscopy with bladder biopsy 32 1.7 Flexible cystoscopy with argon plasma coagulation (APC)/cystodiathermy 35 1.8 Clinical breast examination 38 1.9 Core breast biopsy 41 1.10 Breast fine-needle aspiration (FNA) 43 1.11 Breast punch biopsy 45 1.12 Nipple discharge smear 47 2 Haematological procedures 57 Overview 58 Bone marrow procedures 58 Aspiration and trephine biopsy 58 Bone marrow harvest 67 Apheresis 72 Ribavirin administration 80 Pentamidine isetionate administration 84 Websites 87 References 87 Procedure guidelines for Chapter 2 2.1 Bone marrow aspiration and trephine biopsy 64 2.2 Bone marrow harvest 68 2.3 Apheresis 76 2.4 Ribavirin administration 82 2.5 Pentamidine isetionate administration 85 3 Cancer pain assessment and management 91 Overview 92 Cancer pain assessment and management 95 Pain management 97 Acupuncture 104 Interventional techniques for managing complex cancer-related pain 107 Single nerve blocks and injections 108 Regional peripheral and plexus nerve blocks and infusions 108 Neuraxial (spinal) blocks: epidural and intrathecal analgesia 109 Entonox (nitrous oxide) administration 120 References 125 Procedure guidelines for Chapter 3 3.1 Acupuncture: preparation and administration 106 3.2 Epidural/intrathecal sensory blockade: assessment 114 3.3 Epidural/intrathecal exit site dressing change 115 3.4 Epidural/intrathecal catheter removal 115 3.5 Entonox administration 123 4 Administration of systemic anticancer therapies 131 Overview 132 Systemic anticancer treatment 132 Safe handling of hazardous drugs 133 Administration of cytotoxic medications by nurses 137 Intravenous administration of systemic anticancer therapy 138 Extravasation 142 Oral administration of systemic anticancer therapy 156 Intramuscular and subcutaneous administration of cytotoxic drugs 162 Topical application of cytotoxic drugs 164 Intrathecal administration of cytotoxic drugs 165 Intrapleural instillation of cytotoxic drugs 168 Intravesical instillation of cytotoxic drugs 169 Intraperitoneal instillation of cytotoxic drugs 172 Intra-arterial administration of cytotoxic drugs 173 Side-effects of chemotherapy 175 Haematological side-effects 176 Fatigue 176 Gastrointestinal side-effects 176 Adverse drug reactions 177 Neurotoxicity 177 Mucositis/stomatitis 177 Nephrotoxicity/haemorrhagic cystitis 178 Cardiotoxicity 178 Pulmonary toxicity 178 Hepatotoxicity 178 Skin toxicities 178 Alopecia 178 Clinical research 184 References 193 Procedure guidelines for Chapter 4 4.1 Cytotoxic spillage management 135 4.2 Cytotoxic therapy: intravenous administration of cytotoxic drugs 141 4.3 Extravasation management: peripheral cannula 150 4.4 Extravasation: performing flush-out following an extravasation 152 4.5 Cytotoxic therapy: education for patients on oral cytotoxic drugs 161 4.6 Cytotoxic therapy: intramuscular administration of cytotoxic drugs (Z-track) 163 4.7 Cytotoxic therapy: topical application of cytotoxic drugs 164 4.8 Cytotoxic therapy: intraventricular administration of cytotoxic drugs via an intraventricular access device (Ommaya reservoir) 166 4.9 Cytotoxic therapy: intrapleural instillation of cytotoxic drugs 168 4.10 Cytotoxic therapy: intravesical instillation of cytotoxic drugs 170 4.11 Cytotoxic therapy: intraperitoneal instillation of cytotoxic drugs 172 4.12 Intra-arterial administration of cytotoxic drugs 174 4.13 Scalp cooling 182 5 Radionuclide therapy 201 Overview 202 Radiation 202 Radiation protection 202 Unsealed source therapy 207 Sealed source therapy 211 Sealed source iodine-125 seeds used in prostate malignancies 220 Intraoral sealed sources 220 Websites 223 References 223 Procedure guidelines for Chapter 5 5.1 Radiation protection: major spillage of radioactive body fluids through incontinence and/or vomiting 204 5.2 Radiation protection: contamination of bare hands by radioactive body fluids 205 5.3 Radiation protection: death of a patient who has received unsealed radioactive source therapy 205 5.4 Radiation protection: cardiac arrest of a patient who has received unsealed radioactive source therapy 205 5.5 Radiation protection: evacuation due to fire of patients who have received unsealed radioactive source therapy 206 5.6 Unsealed source therapy: entering and leaving the room of a patient who has received an unsealed radioactive source 208 5.7 Unsealed source therapy: iodine-131 (oral capsule/liquid): administration 209 5.8 Unsealed source therapy: iodine-131 mIBG treatment: patient care 209 5.9 Sealed source therapy: caesium sources (manual or afterloading): patient care 216 5.10 Sealed source therapy: low dose-rate Selectron treatment 217 5.11 Sealed source therapy: Selectron applicator removal 218 5.12 Sealed source therapy: insertion of sealed radioactive sources into the oral cavity 221 6 Wound management 227 Overview 228 Malignant fungating wounds 228 Wound assessment 230 Treatment options 232 Principles of the management of dressings for a malignant fungating wound 235 Local wound management 235 Graft-versus-host disease wounds 244 Definition 244 Skin care following radiotherapy 245 Websites and useful addresses 249 References 249 Procedure guidelines for Chapter 6 6.1 Assessing a malignant fungating wound 231 6.2 Dressing a malignant fungating wound 243 7 Acute oncology 253 Overview 254 Haematological emergencies 255 Central venous access device complications 255 Thrombosis (catheter related) 259 Sepsis 260 Major artery rupture 261 Superior vena cava obstruction 262 Metabolic emergencies 264 Hypercalcaemia of malignancy 264 Hypomagnesaemia 267 Side-effects from chemotherapy agents 268 Diarrhoea (chemotherapy and radiotherapy induced) 268 Nausea and vomiting 271 Neutropenic sepsis 277 Pneumonitis 280 Structural 281 Ascites (malignant) 281 Bowel obstruction (malignant) 287 Metastatic spinal cord compression 289 Pericardial effusion (malignant) 301 Raised intracranial pressure due to malignant disease 302 References 303 Procedure guidelines for Chapter 7 7.1 Carotid artery rupture (CAR) 262 7.2 Abdominal paracentesis 284 7.3 Log rolling for suspected/confirmed cervical spinal instability 292 7.4 Positioning for suspected/confirmed cervical spinal instability: pelvic twist to right 295 7.5 Log rolling for suspected/confirmed thoracolumbar spinal instability 297 7.6 Early mobilization of the patient in bed 298 8 Living with and beyond cancer 311 Overview 312 Section 8.1 Introduction 312 The experience of living with or beyond cancer 312 Section 8.2 Welfare advice 315 Overview 315 Websites 326 Useful addresses 326 Section 8.3 Supporting individuals with sexual concerns as a consequence of cancer 326 Women’s sexual concerns following cancer 329 Interventions 331 Men’s sexual concerns following cancer 332 Interventions 333 Websites 334 Section 8.4 Nutritional status 334 Websites 339 Section 8.5 Compression therapy in the management of lymphoedema 339 Lymphoedema 339 Assessment of the patient with lymphoedema and calculation of limb volume 341 Compression bandaging 348 Compression garments 357 Adjustable wrap compression systems 361 Websites 365 Section 8.6 Non-pharmacological management of breathlessness 366 Non-pharmacological support 367 Websites 371 Section 8.7 Physical activity for people with cancer 371 Websites 377 Section 8.8 Cancer-related fatigue and sleep 377 Cancer-related fatigue 377 Sleep 380 Section 8.9 Communication for a patient with a laryngectomy 383 Websites and useful addresses 389 Section 8.10 Nipple tattooing 390 References 396 Procedure guidelines for Chapter 8 8.1 Conducting a holistic needs assessment (HNA) 314 8.1a Developing and actioning a care plan 315 8.1b Closure and follow-up 315 8.2 How a patient should make a claim for Personal Independence Payment 322 8.3 How a patient should make a claim for Attendance Allowance 323 8.4 How a patient should make a claim for Carer’s Allowance 324 8.5 How a patient should make a claim for Employment and Support Allowance 325 8.6 Assessing a patient’s sexual health concerns 327 8.7 Measuring the weight, height and waist circumference of the patient 336 8.8 Compression therapy limb volume calculation: lower limb 346 8.9 Compression therapy limb volume calculation: upper limb 346 8.10 Compression bandaging (multilayer short-stretch): bandaging arm and the fingers 350 8.11 Compression bandaging (multilayer short-stretch): bandaging a leg and the toes 354 8.12 Elastic compression garments: application to the leg 359 8.13 Elastic compression garments: application to the arm 360 8.14 Adjustable wrap compression system: application to the lower leg 363 8.15 Adjustable wrap compression system: application to the arm 364 8.16 Breathlessness management: using a handheld fan 368 8.17 Breathlessness management: essential oil administration via aroma stick inhaler 370 8.18 Supporting physical activity 375 8.19 Fatigue management 378 8.20 Relaxation and anxiety management 382 8.21 HME placement 387 8.22 Voice prosthesis: cleaning in situ 388 8.23 Nipple tattooing 394 9 End of life care 403 Overview 404 Last Offices 408 Websites and useful addresses 416 Online resources 416 References 416 Procedure guideline for Chapter 9 9.1 Last Offices 411 Index 419

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Book SynopsisUnique among medical texts, the Oxford Handbook of Clinical Medicine is a complete and concise guide to the core areas of medicine that also encourages thinking about the world from the patient''s perspective, to develop a holistic approach to care with a passion for practice. Now in its eleventh edition, this renowned Handbook has been fully updated to reflect the latest changes in clinical practice and best management, filled with expert knowledge, practical advice, and reassurance. In the tradition of bringing new voices to each edition, three authors have joined the writing team, bringing a fresh perspective to the content. The chapters on emergencies, endocrinology and diabetes, haematology, oncology, and surgery have been completely revamped, and every page has been reviewed by a consultant and a trainee to ensure it continues to be accurate, relevant, and user-friendly. Figures and illustrations have been carefully revised and updated in response to reader feedback, and key refe

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Book SynopsisNow in its fifth edition, the Oxford Handbook of Emergency Medicine is the essential rapid-reference guide to emergency medicine for everyone from junior doctors to specialist registrars, nurse practitioners, and paramedics. New and improved, the Handbook has been thoroughly revised throughout, with 100 extra illustrations and the latest guidelines and treatment advice, completely overhauled chapters on Medicine, Obstetrics and Gynaecology, and Paediatric emergencies, and new topics on treatment escalation, end-of-life care, and sepsis.Clear and concise, extensively updated, and packed with a host of new X-rays to aid identification and treatment, this Handbook has everything you need to thrive in the demanding world of emergency medicine today.Trade ReviewThe text is straight to the point, concise, informative and educational which also helps to improve patient care. Yet it is surprisingly comprehensive for this size of book and a lot of common and less common situations are covered in significant depth. This is achieved in part, because every word counts and the text is straight to the point. Exactly what many people want. * Dr Harry Brown, Glycosmedia *Review from previous edition The Fourth Edition of the Oxford Handbook of Emergerncy Medicine is proof that good things come in small packages. This compact little powerhouse more than lives up to expectations established by earlier editions. It offers sound clinical guidance in an easily accessible format and would be a handy addition to the pockets of emergency medicine clinicians. * Journal of the American Medical Association *Table of Contents1: General approach 2: Life-threatening emergencies 3: Medicine 4: Toxicology 5: Infectious diseases 6: Environmental emergencies 7: Analgesia and anaesthesia 8: Major trauma 9: Wounds, fractures, orthopaedics 10: Surgery 11: Ophthalmology 12: Ear, nose, and throat 13: Obstetrics and gynaecology 14: Psychiatry 15: Paediatric emergencies

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Book SynopsisTable of Contents1 Managing clinical encounters with patients 2 General aspects of history taking 3 General aspects of examination 4 The cardiovascular system 5 The respiratory system 6 The gastrointestinal system 7 The nervous system 8 The visual system 9 The ear, nose and throat 10 The endocrine system 11 The reproductive system 12 The renal system 13 The musculoskeletal system 14 The skin, hair and nails 15 Babies and children 16 Patients with mental illness and learning disability 17 The frail patient 18 The deteriorating patient 19 The dying patient 20 Reaching and communicating a diagnosis 21 Adapting skills for practice 22 Preparing for assessment Index

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Book SynopsisTable of ContentsPreface ix Part 1 Handling data 1 1 Types of data 2 2 Data entry 4 3 Error checking and outliers 6 4 Displaying data diagrammatically 8 5 Describing data: the ‘average’ 10 6 Describing data: the ‘spread’ 12 7 Theoretical distributions: the Normal distribution 14 8 Theoretical distributions: other distributions 16 9 Transformations 18 Part 2 Sampling and estimation 21 10 Sampling and sampling distributions 22 11 Confidence intervals 24 Part 3 Study design 27 12 Study design I 28 13 Study design II 31 14 Clinical trials 34 15 Cohort studies 37 16 Case–control studies 40 Part 4 Hypothesis testing 43 17 Hypothesis testing 44 18 Errors in hypothesis testing 47 Part 5 Basic techniques for analysing data 51 Numerical data 19 Numerical data: a single group 52 20 Numerical data: two related groups 54 21 Numerical data: two unrelated groups 57 22 Numerical data: more than two groups 60 Categorical data 23 Categorical data: a single proportion 63 24 Categorical data: two proportions 66 25 Categorical data: more than two categories 69 Regression and correlation 26 Correlation 72 27 The theory of linear regression 75 28 Performing a linear regression analysis 77 29 Multiple linear regression 81 30 Binary outcomes and logistic regression 85 31 Rates and Poisson regression 89 32 Generalized linear models 93 33 Explanatory variables in statistical models 96 Important considerations 34 Bias and confounding 100 35 Checking assumptions 104 36 Sample size calculations 107 37 Presenting results 111 Part 6 Additional chapters 115 38 Diagnostic tools 116 39 Assessing agreement 119 40 Evidence-based medicine 124 41 Methods for clustered data 127 42 Regression methods for clustered data 130 43 Systematic reviews and meta-analysis 134 44 Survival analysis 138 45 Bayesian methods 142 46 Developing prognostic scores 144 Appendices 147 A Statistical tables 148 B Altman’s nomogram for sample size calculations (Chapter 36) 155 C Typical computer output 156 D Checklists and trial profile from the EQUATOR network and critical appraisal templates 169 E Glossary of terms 178 F Chapter numbers with relevant multiple-choice questions and structured questions from Medical Statistics at a Glance Workbook 188 Index 190

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Book SynopsisTable of ContentsList of abbreviations Introduction The top 100 drugs listed by system The top 100 drugs listed by indication The top 100 drugs (alphabetical listing) 5a-reductase inhibitors a-blockers Acetylcholinesterase inhibitors Acetylcysteine (N-acetylcysteine) Activated charcoal Adenosine Adrenaline (epinephrine) Aldosterone antagonists Alginates and antacids Allopurinol Aminoglycosides Aminosalicylates Amiodarone Angiotensin-converting enzyme (ACE) inhibitors Angiotensin receptor blockers Antidepressants, selective serotonin reuptake inhibitors Antidepressants, tricyclics and related drugs Antidepressants, venlafaxine and mirtazapine Antiemetics, dopamine D2-receptor antagonists Antiemetics, histamine H1-receptor antagonists Antiemetics, serotonin 5-HT3-receptor antagonists Antifungal drugs Antihistamines (H1-receptor antagonists) Antimotility drugs Antimuscarinics, bronchodilators Antimuscarinics, cardiovascular and gastrointestinal uses Antimuscarinics, genitourinary uses Antipsychotics, first-generation (typical) Antipsychotics, second-generation (atypical) Antiviral drugs Antiplatelet drugs, ADP-receptor antagonists Antiplatelet drugs, aspirin Azathioprine ß-blockers ß2-agonists Benzodiazepines Bisphosphonates Calcium and vitamin D Calcium channel blockers Carbamazepine Cephalosporins and carbapenems Chloramphenicol Corticosteroids (glucocorticoids), inhaled Corticosteroids (glucocorticoids), systemic Corticosteroids (glucocorticoids), topical Digoxin Dipeptidylpeptidase-4 inhibitors Direct oral anticoagulants Diuretics, loop Diuretics, thiazide and thiazide-like Dopaminergic drugs for Parkinson's disease Emollients Fibrinolytic drugs Gabapentin and pregabalin H2-receptor antagonists Heparins and fondaparinux Insulin Iron Lamotrigine Laxatives, osmotic Laxatives, stimulant Leukotriene receptor antagonists Levetiracetam Lidocaine Macrolides Metformin Methotrexate Metronidazole Naloxone Nicotine replacement and related drugs Nitrates Nitrofurantoin Non-steroidal antiinflammatory drugs Ocular lubricants (artificial tears) Oestrogens and progestogens Opioids, strong Opioids, weak/moderate Oxygen Paracetamol Penicillins Penicillins, antipseudomonal Penicillins, broad-spectrum Penicillins, penicillinase-resistant Phosphodiesterase (type 5) inhibitors Prostaglandin analogue eye drops Proton pump inhibitors Quinine Quinolones Serotonin 5-HT1-receptor agonists Sex hormone antagonists for breast cancer Statins Sulphonylureas Tetracyclines Thyroid hormones Trimethoprim Valproate (valproic acid) Vancomycin Vitamins Warfarin Z-drugs Fluids Colloids (plasma substitutes) Compound sodium lactate (Hartmann's solution) Glucose (dextrose) Potassium chloride Sodium chloride Self-assessment and knowledge integration 100 single best-answer questions Answers and explanations Index

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Book SynopsisReturning for a fourth edition, Oxford Assess and Progress: Situational Judgement Test is the definitive guide for students preparing to sit the Situational Judgement Test (SJT) for entry into the UK Foundation Programme. Featuring over 300 practical questions mapped to the Foundation Programme curriculum and latest GMC guidance, this new edition has been fully updated to maximise your SJT score.All scenarios are based on real experiences informed by practising doctors and medical students who have sat the SJT to ensure that the questions closely mirror the content of the real exam. Two practice tests allow candidates to prepare for exam day and practice their timings - one of the biggest challenges in the exam.Written by junior doctors and overseen by experts in medical assessment, this guide demystifies the SJT, allowing you to achieve the best possible score and take control of the first stage of your medical career.Trade ReviewReview from previous edition Review from previous edition I was one of the original guinea pigs for the SJT. If I had this book before I sat the exam I would have aced it. This book shows you exactly what the markers are looking for, where to find valuable pre-reading material and the practice questions are impressively like those in the real SJT. * Mubeen Iqbal, FY1, North Central Thames Deanery *An excellent book that I would recommend to other students. It certainly has made the exam feel less daunting and I feel more prepared having used this book. * Raymand Pang, 4th year Med Student, Warwick University *Having done the SJT I feel that this is the best resource available. * Amazon customer review *When it comes to providing questions that represent the SJT there is no better book. * Amazon customer review *Table of ContentsSection 1: Introduction to the SJT 1: Foundation Programme selection 2: What is the SJT? 3: What does the SJT test? 4: What does the SJT test? 5: How are SJT questions created? 6: How can you prepare? 7: Tips for the SJT 8: How to use this book Section 2: Questions 9: Commitment to professionalism 10: Coping with pressure 11: Effective communication 12: Patient focus 13: Working effectively as part of a team Section 3: Practice test 14: Practice test

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Book SynopsisPocket Medicine, 8th Edition, is a must-have resource for fast answers to the diagnostic and therapeutic questions you’ll face on rounds and exams. Edited by Dr. Marc S. Sabatine and compiled by residents, fellows, and attending physicians at the world-renown Massachusetts General Hospital, this best-selling reference provides dependable, up-to-date information needed to make an accurate diagnosis and develop a state-of-the-art treatment plan. Featuring easily accessible bulleted lists, tables, and algorithms, Pocket Medicine provides focused coverage of internal medicine in the traditional, easy-to-use binding you know and love. Offers fast and easy access to essential information on the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology. Includes references to landmark papers to help you intelligently answer questions on rounds–all from a trusted source acceptable for use on rounds. Features user-friendly tabs and a two-color design to help you find information quickly, as well as a full-color, 16-page insert featuring radiology and pathology images. Provides ideal coverage for medical students, interns, residents, advanced practice nurses, and PAs. Prepare for board exams! Mirroring the organization of Pocket Medicine, Pocket Medicine High-Yield Board Review features 500 practice questions so you can practice for your board exam.

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Book SynopsisTable of ContentsAcknowledgments viii How to Use This Book ix This book is neither a comprehensive text nor an exam-review tool. It is an overview of the immune system, designed to give anyone who is learning immunology a feel for how the system fits together. About the Companion Website x Lecture 1 An Overview 1 The immune system is a “team effort,” involving many different players who work together to provide a powerful defense against invaders. Focusing on one player at a time makes it hard to understand the game. Here we view the action from the grandstand to get a wide-angle picture of what the immune system is all about. Lecture 2 The Innate Immune System 12 The innate immune system is a “hard-wired” defense that has evolved over millions of years to recognize pathogens that commonly infect humans. It provides a rapid and powerful response against “everyday” invaders. Lecture 3 B Cells and Antibodies 26 B cells and the antibodies they produce are part of the adaptive immune system – a system that protects us against pathogens both common and rare. Lecture 4 The Magic of Antigen Presentation 40 T cells, another weapon of the adaptive immune system, only recognize invaders that are properly presented by specialized antigen presenting cells. This feature keeps T cells focused on the types of attackers they can defend against. Lecture 5 T Cell Activation 52 Before they can spring into action, T cells must be activated. This requirement helps insure that only useful weapons will be mobilized. Lecture 6 T Cells at Work 60 Once they have been activated, helper T cells orchestrate the immune response, and killer T cells destroy infected cells. Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking 69 B and T lymphocytes travel through secondary lymphoid organs looking for the intruders they can defend against. Once activated in the secondary lymphoid organs, B and T cells are dispatched to the particular areas of the body where they can be most useful. Lecture 8 Restraining the Immune System 82 The powerful weapons of the immune system must be restrained lest they become overly exuberant. In addition, once an invader has been defeated, the immune system must be “reset” to prepare for future attacks. Lecture 9 Self Tolerance and MHC Restriction 86 T cells must be “tested” to be sure they focus on appropriately presented antigens, and B and T lymphocytes must be screened to eliminate those which might attack our own bodies. Lecture 10 Immunological Memory 97 The innate immune system remembers pathogens which have been attacking humans for millions of years. In contrast, B and T cells remember pathogens we have encountered during our lifetime. Memory B and T lymphocytes respond more quickly and effectively to a subsequent attack by the same invader. Lecture 11 The Intestinal Immune System 103 The human intestines are home to trillions of bacteria, viruses, fungi, and parasites. How the immune system deals with these potentially dangerous intestinal residents, which frequently invade the tissues surrounding the intestines, is a hot topic in immunology. Lecture 12 The Immune System Gone Wrong 110 The immune system usually does a good job of defending us. Sometimes, however, mistakes are made. Two examples of the “immune system gone wrong” are allergies and autoimmunity. Lecture 13 Immunodeficiency 119 Serious disease may result when our immune system does not operate at full strength. Humans who are infected with HIV-1 have profoundly impaired immune systems. Lecture 14 Vaccines 125 Vaccines safely mimic a microbial attack so that our immune system will be primed and ready for a future challenge by the same pathogen. Lecture 15 Cancer and the Immune System 132 The human immune system is not very good at defending us against cancer. Indeed, there is a built-in conflict between the need to minimize the chance that its weapons will attack our own bodies and the need to destroy cancer cells. Lecture 16 Immunotherapy 139 Physicians are “borrowing” some of the weapons of the immune system and using them to treat disease. Lecture 17 COVID-19 and the Immune System 146 The COVID-19 pandemic has given immunologists a “laboratory” to study the immune response to respiratory viral infections. The COVID-19 vaccine program has resulted in major advances in vaccine design, including the mRNA vaccine platform. Glossary 154 Here are definitions of some of the terms that immunologists use – but which “normal” people wouldn’t. Acronyms and Abbreviations 158 Immunologists are big on acronyms and abbreviations, but they can drive you crazy. So I’ve made a list to which you can refer. Index 159

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Book SynopsisFor over thirty years, the Oxford Handbook of Clinical Specialties has guided students and junior doctors through their clinical placements, renowned for providing all the information needed for both practice and revision in a deceptively small package. Now in its eleventh edition, the Handbook has been revitalized by an expanded team of specialty experts and junior doctors to guide readers through each of the specialties encountered through medical school and Foundation Programme rotations, while remaining true to the humanity and patient focus of the original edition. Updated with the latest advice and clinical guidelines, packed full of high-quality illustrations, boxes, tables, and classifications, and with a brand new chapter on how to survive your junior doctor years and beyond, this handbook is ideal for both study and use at direct point of care. Each chapter is clear and concise and filled with medical gems, with features including ribbons to mark your most-used pages and mnemonics to help you memorize and retain key facts. With reassuring and friendly advice throughout, this is the ultimate guide and revision tool for every medical student and junior doctor for each clinical specialty placement. This well-loved Handbook remains the perfect companion to the Oxford Handbook of Clinical Medicine, together encompassing the entire spectrum of clinical medicine and unmatched by any competitor in their class, helping you become the doctor you want to be.Trade ReviewPretty much a must -- have for medical students having clinical placements, great summaries of all the most important conditions within numerous clinical specialties. Got delivered in perfect condition. * Amazon Review *Absolutely perfect if you've also got the handbook of clinical medicine. Between the two they basically cover most of the med school curriculum. Use this along side NICE CKS, BMJ best practice and passmed and you're sorted. * Medical student, Amazon *Due to the easy-to-read nature of the handbook and the concise way in which is written we would recommend the book to any medical student who is wanting to grasp the concepts of their specialities learning. It has all the information in one place- perfect for notetaking and revision. * North Wing Magazine *As a GP Registrar, I find this book of immense value during my hospital rotations, as well as during my rotation at the GP Surgery. It is also serving me as a source of information to prepare for the Applied Knowledge Test needed for my Certificate of Completion of Training. * Dr Michael Zar, GP Registrar, Glycosmedia *Table of Contents1: Charlotte Goumalatsou: Obstetrics 2: Charlotte Goumalatsou: Gynaecology 3: Simon Buckley: Paediatrics 4: Alastair Denniston, Priscilla Mathewson: Ophthalmology 5: Nicholas Steventon: Ear, nose, and throat 6: Sanju Arianayagam: Dermatology 7: Juliet Clutton: Orthopaedics 8: Juliet Clutton: Trauma 9: Blair Graham: Emergency medicine 10: Terry Collingwood: Pre-hospital emergency medicine 11: Nina Hjelde: Anaesthesia 12: Gil Myers: Psychiatry 13: Andrew Baldwin: General practice 14: Andrew Baldwin: Eponymous syndromes 15: Andrew Baldwin, Gil Myers: Doctors' health and performance

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Book SynopsisThis text is aimed at potential clinical investigators usually physicians, especialy those thinking about doing clinical trials to evaluate new drugs - mostly sponsored by pharmaceutical companies.Table of ContentsIn this book a respected clinical investigator shares his experiences and insights, so that others can share in the excitement of clinical research while avoiding some of the pitfalls that inevitably beset the clinical trialist. This book provides practical advice on how to interact with various ...monitors..., auditors, and project leaders running a trial. It also gives advice on how to recruit patients to the trials. The author examines subjects such as allocation of time, space, and staff. This book is predominantly aimed at doctors performing clinical trials for pharmaceutical companies and will be of great help to Heads of Clinical Research in pharmaceutical companies--also to academic staff in university clinical departments, particularly pharmacology.

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Book SynopsisTable of ContentsPreface vii Acknowledgments ix 1. Basic Nuclear Medicine Physics 1 2. Interaction of Radiation with Matter 21 3. Formation of Radionuclides 33 4. Nonscintillation Detectors 42 5. Scintillation Detectors 62 6. Imaging Instrumentation 74 7. Single‐photon Emission Computed Tomography (SPECT) 92 8. Positron Emission Tomography (PET) 103 9. X‐ray Computed Tomography (CT) 117 10. Magnetic Resonance Imaging (MRI) 128 11. Hybrid Imaging Systems: PET‐CT SPECT‐CT and PET‐MRI 145 12. Image Reconstruction Processingand Display 151 13. Information Technology 181 14. Quality Control 189 15. Radiation Biology 209 16. Radiation Dosimetry 222 17. Radiation Safety 231 18. Radiopharmaceutical Therapy 239 19. Management of Nuclear Event Casualties 256 Appendix A: Common Nuclides 269 Appendix B: Major Dosimetry for Common Pharmaceuticals 271 Appendix C: Guide to Nuclear Regulatory Commission (NRC) Publications 273 Appendix D: Recommended Reading by Topic 276 Index 278

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Book SynopsisThe time-tested, most popular board prep resource?updated to reflect the newest Step 1 examFirst Aid for the USMLE Step 1 is a veritable blueprint for preparing for this critical exam, revealing all the content you will encounter on test day. This unmatched text is written by carefully chosen students who excelled on the Step 1 exam and reviewed by top faculty?ensuring the content is relevant, high-yield, and accurate. The book is organized and formatted in ways that help you easily hone in on the most important content.The new edition ofFirst Aid for the USMLE Step 1 is filled with 1,000 color clinical images, including more depicting diverse patients; 1,300+ high-yield facts and mnemonics, organized into basic principles and organ system; and invaluable test-taking advice. There?s a reason for the longstanding success of First Aid for the USMLE Step 1. Once you open the 2024 edition, you?ll instantly understand why it?s a resource you can?t be without!

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Book SynopsisTrade ReviewPraise for the 4th edition"Frayn and Evans have done a marvellous job of updating this textbook to reflect recent developments in metabolic research ... I now have the relatively simple task of updating my reading list for this coming year's lectures to recommend this terrific new edition." (Physiology News Autumn 2019, Issue 116) "This textbook has been a masterpiece since the first edition ... by giving a superb explanation of human metabolism to range a wide readers and students. “Human Metabolism” has remained a favorite reference for many teachers of students of a variety of medical programs be it medicine, nursing or biochemistry ... With each edition the book has improved by providing up to date information in a key and basic field of medicine where knowledge has been moving very fast in the last 25 years." (Clinical Nutrition)“Based on its highly regarded predecessor – Metabolic Regulation: A Human Perspective – this book has been given a noticeable overhaul in both content and title. Unlike the many other texts available that are dominated by the intricacies of biochemistry, this book seeks to offer readers from clinical and sports science backgrounds practical insights into human metabolism ... The authors’ relaxed writing styles make reading about complex themes interesting and, dare I say it, fun ... The readability also extends to the layout, which is uncluttered and easy to navigate. Abundant colourful diagrams interspersed throughout succeed in consolidating the knowledge conveyed narratively in the text ... Human Metabolism is undoubtedly a highly readable resource that will have broad appeal for those with an interest in physiology and nutrition. Overall, I would certainly recommend it as a useful addition to any trainee’s library.” (The Bulletin of the Royal College of Pathologists) Praise for the previous edition “I had the great pleasure of reading your impressive text. While I realize that your intended market is certainly not people such as myself (I read it to better understand my own health and body), it is surprisingly well suited for that purpose: being both dense in useful information and surprisingly accessible to non-specialist readers. I appreciated several things about your book -- that you kept the text relatively short for an academic text; that you made it largely self-contained (I especially appreciate your care in providing internal cross references in the book); that you put much of the content into tables, boxes, and diagrams … I learned a great deal from the book, and it has substantially increased the quality of my interactions with my own physician” (Doug Tygar, Professor of Computer Science & Information, UC Berkeley, USA) "It is hard to find a textbook that gives a better basis for the understanding of Human metabolism and nutrition, that is so well designed and actually quite fun to read as this one. This book is my first choice for a textbook for my medical students and for nursing school too. It is well suited for any kind of studies of metabolism at a higher level because of its ease at explaining the basics and the frameworks needed for the understanding of metabolism. It is the first book I give to my doctorial students when they need to freshen up their knowledge and the basics in metabolism when starting research in clinical nutrition and metabolism...if anyone is looking for the most interesting and fun book to read as an in depth introduction to human metabolism and nutrition, this is it!" (Clinical Nutrition) Table of ContentsPreface vi Abbreviations vii About the companion website xi 1 The underlying principles of human metabolism 1 2 Cellular aspects of metabolic regulation 48 3 Coordination of metabolism in the whole body 76 4 Digestion and intestinal absorption 93 5 Metabolic specialisation of organs and tissues 118 6 Communication systems 173 7 Integration of carbohydrate, fat and protein metabolism in normal daily life 204 8 Metabolic challenges: Coping with some extreme physiological situations 245 9 Metabolic challenges: Coping with some pathological situations 277 10 Lipoprotein metabolism and atherosclerosis 302 11 Energy balance and body weight regulation 325 12 Diabetes mellitus 346 Index 365

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Book SynopsisTable of ContentsPreface to the Fifth Edition ix Acknowledgments xi List of Acronyms xiii Equation symbols xvii About the Companion Website xix Chapter 1 Basic principles 1 Introduction 1 Atomic structure 2 Motion in the atom 2 MR active nuclei 4 The hydrogen nucleus 5 Alignment 6 Net magnetic vector (NMV) 8 Precession and precessional (Larmor) frequency 10 Precessional phase 13 Resonance 13 MR signal 18The free Induction decay(FDI) signal 20Pulse timing parameters 22 Chapter 2 Image weighting and contrast 24 Introduction 24 Image contrast 25 Relaxation 25 T1 recovery 26 T2 decay 27 Contrast mechanisms 31 Relaxation in different tissues 32 T1 contrast 36 T2 contrast 40 Proton density contrast 41 Weighting 42 Other contrast mechanisms 51 Chapter 3 Spin echo pulse sequences 58 Introduction 58 RF rephasing 59 Conventional spin echo 65 Fast or turbo spin echo FSE/TSE) 68 Inversion recovery (IR) 78 Short tau inversion recovery (STIR) 82 Fluid attenuated inversion recovery (FLAIR) 84 Chapter 4 Gradient echo pulse sequences 89 Introduction 89 Variable flip angle 90 Gradient rephasing 91 Weighting in gradient echo pulse sequences 94 Coherent or rewound gradient echo 106 Incoherent or spoiled gradient echo 109 Reverse-echo gradient echo 113 Balanced gradient echo 119 Fast gradient echo 122 Echo planar imaging (EPI) 122 Chapter 5 Spatial encoding 128 Introduction 128 Mechanism of gradients 129 Gradient axes 134 Slice-selection 135 Frequency encoding 142 Phase encoding 145 Bringing it all together – pulse sequence timing 152 Chapter 6 k-space 158 Introduction 158 Part 1 – what is k-space? 159 Part 2 - how are data acquired and how are images created from this data? 165 Part 3 –some important facts about k-space 184 Part 4: how do pulse sequences fill k-space? 197 Part 5: options that fill k-space 199 Chapter 7 Protocol optimization 209 Introduction 209 Signal-to-noise ratio (SNR) 210 Contrast-to-noise ratio (CNR) 226 Spatial resolution 232 Scan time 237 Trade-offs 238 Protocol development and modification 238 Chapter 8 Artefacts 242 Introduction 242 Phase mismapping 243 Aliasing 253 Chemical shift artefact 261 Out-of-phase signal cancellation 265 Magnetic susceptibility artefact 269 Truncation artefact 272 Cross-excitation/cross-talk 273 Zipper artefact 275 Shading artefact 276 Moiré artefact 277 Magic angle 279 Equipment faults 280 Flow artefacts 280 Flow-dependent (non-contrast enhanced) angiography 298 Black-blood imaging 303 Phase contrast MRA 304 Chapter 9 Instrumentation 311 Introduction 311 Magnetism 313 Scanner configurations 315 Magnet system 318 Magnet shielding 326 Shim system 328 Gradient system 330 RF system 337 Patient transport system 343 Computer system and graphic user interface 344 Chapter 10 MRI safety 346 Introduction (and disclaimer) 346 Definitions used in MRI safety 347 Psychological effects 350 The spatially-varying static field 351 Electromagnetic (radiofrequency) fields 357 Time-Varying Gradient Magnetic Fields 363 Cryogens 365 Safety tips 367 Additional resources 368 Glossary 370 Index 387

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Book SynopsisTable of ContentsPreface Learning objectives Handling data 1 Types of data 2 Data entry 3 Error checking and outliers 4 Displaying data diagrammatically 5 Describing data: the ‘average’ 6 Describing data: the ‘spread’ 7 Theoretical distributions: the Normal distribution 8 Theoretical distributions: other distributions 9 Transformations Sampling and estimation 10 Sampling and sampling distributions 11 Confidence intervals Study design 12 Study design I 13 Study design II 14 Clinical trials 15 Cohort studies 16 Case–control studies Hypothesis testing 17 Hypothesis testing 18 Errors in hypothesis testing Basic techniques for analysing data Numerical data 19 Numerical data: a single group 20 Numerical data: two related groups 21 Numerical data: two unrelated groups 22 Numerical data: more than two groups Categorical data 23 Categorical data: a single proportion 24 Categorical data: two proportions 25 Categorical data: more than two categories Regression and correlation 26 Correlation 27 The theory of linear regression 28 Performing a linear regression analysis 29 Multiple linear regression 30 Binary outcomes and logistic regression 31 Rates and Poisson regression 32 Generalized linear models 33 Explanatory variables in statistical models Important considerations 34 Bias and confounding 35 Checking assumptions 36 Sample size calculations 37 Presenting results Additional chapters 38 Diagnostic tools 39 Assessing agreement 40 Evidence-based medicine 41 Methods for clustered data 42 Regression methods for clustered data 43 Systematic reviews and meta-analysis 44 Survival analysis 45 Bayesian methods 46 Developing prognostic scores Appendices A Statistical tables B Altman’s nomogram for sample size calculations C Typical computer output D EQUATOR network checklists and critical appraisal templates E Glossary of terms F Chapter numbers with relevant multiple-choice questions and structured questions from Medical Statistics at a Glance Workbook Index Medical Statistics at a Glance Workbook Introduction Part 1: MCQs Handling data Sampling and estimation Study design Hypothesis testing Basic techniques for analysing data Additional techniques Part 2: Structured Questions Part 3: Critical appraisal Randomised controlled trial: template Paper 1: a randomised controlled trial Observational study: template Paper 2: an observational study Part 4: Data analysis Dataset 1 analysed by Stata v11 Dataset 2 analysed using IBM SPSS Statistics v20 Part 5: Solutions Solutions to MCQs Model answers for structured questions Critical appraisal of Paper 1 Critical appraisal of Paper 2 Appendices Appendix I: List of MCQs with relevant chapters from Medical Statistics at a Glance (3rd edn) and associated topics Appendix II: List of structured questions with relevant chapters from Medical Statistics at a Glance (3rd edn) and associated topics Appendix III: Chapters from Medical Statistics at a Glance with relevant MCQs and Structured questions

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Book SynopsisABC of Clinical Resilience ABC of Clinical ResilienceFor the healthcare professional, clinical resilience is about reconnecting with those stirrings which first motivated us to spend a career in the service of others. It is about recovering and maintaining the ???joy of practice??? which nourishes and satisfies our curiosity about the uniqueness of every person in our care. Being a resilient practitioner is essential for our personal wellbeing and also for the safety of our patients, who depend on our ability to optimise our physical and cognitive performance. Yet many healthcare professionals report experiencing burnout. ABC of Clinical Resilience summarises current evidence on how cognitive performance and wellbeing of healthcare professionals are affected by the emotional context of providing care and the organisational culture of working environments. As well as considering impacts of individuals and teams, we also consider how resilience can be recovered for the benefit of everyone. Topics include: The emotional impact of working in healthcareResilience and cognitive performancePracticing self-careThe physiology of resilienceIntelligent kindnessKindness in teamsResilience in practiceOrganisational kindnessTeaching resilience Perfect for both novice and experienced healthcare professionals, including those working in mental health, ABC of Clinical Resilience will also earn a place in the libraries of professionals who treat healthcare workers and readers interested in the psychology and prevention of burnout, vicarious trauma, and moral injury. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/emailTable of ContentsContributors Preface 1. Why resilience? Why now? 2. Emotional impact of working in healthcare 3. Resilience and cognitive performance 4. Practising self-care 5. The physiology of resilience and wellbeing 6. Intelligent kindness 7. Kindness in healthcare teams 8. Organisation kindness 9. Resilience and intelligent kindness in practice 10. Can we really teach resilience, intelligent kindness and compassion? Recommended Books, Articles and Websites Index

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisMedical practice in the modern age requires familiarity with clinical guidelines and standards, which are often published separately in long and discursive documents. This new addition to the Oxford Medical Publications summarises the key clinical practice guidelines which all final year medical students and Foundation Year 1 and 2 doctors should know when managing common conditions. Logically organised by medical specialty, the reader can quickly familiarise themselves with the key principles of diagnosis and management at the appropriate level for beginning a new rotation on the wards. Each guideline summary is tailored to the education level expected of doctors in their first two years of training, with clear instructions for when a more senior colleague should be called upon to help. Written by a team of junior doctors under the supervision of senior clinicians, this is the first resource to distil a range of guidelines from different locations (such as NICE, SIGN, and more) into aTrade ReviewIncredibly thorough and really well thought out. This [book] would be incredibly helpful both in clinical practice day to day and as a tool to prepare for exams * Foundation Year 1 doctor (newly qualified doctor), Croydon University Hospital, UK *Perfectly pitched to its target audience. I wish I had this book when I started as a medical trainee * ST1 Radiology Trainee, University Hospital Southampton, UK *Clear, informative, and full of detail * Internal medical trainee stage 2 (qualified doctor for 4 years), County Durham and Darlington Foundation Trust, UK *The book will be a valuable resource for students and trainees seeing patients in the clinic or hospital. It will also be beneficial for more experienced general practice doctors, as a refresher for infrequently seen conditions. The book can serve as a reference text in a medical school library, as it provides an overview of topics likely to be on in-training tests. I recommend this book to physicians-in-training in the U.K., especially trainees in medical school and general practice. * Jack Harrigan, MD Candidate (University of Kansas School of Medicine - Wichita) *Table of ContentsPart 1 Cardiology:Benjamin Bussman, Liora Wittner, Emily Yeung, Rebecca Webb-Mitchell: 1: Acute coronary syndromes 2: Acute heart failure 3: Aortic stenosis and mitral regurgitation 4: Atrial fibrillation 5: Chronic heart failure 6: Hypertension 7: Pericardial diseases 8: Stable angina 9: Transient loss of consciousness Part 2 Care of the elderly:Elizabeth Tan, Stephanie Choo: 10: Delirium 11: Dementia 12: Falls 13: Hip fractures Part 3 Endocrinology:David Fisher, Sabrina Ahmed, Tom Owens, Nicola West, Laura Brodie, James Andren, Alison Hare, Ben Coombs, Vanessa Jessop, Adam Maxwell: 14: Adrenal insufficiency 15: Diabetic ketoacidosis 16: Hypercalcaemia 17: Hyperglycaemia 18: Hyperglycaemic hyperosmolar syndrome 19: Hyperthyroidism 20: Hypocalcaemia 21: Hypoglycaemia 22: Hyponatraemia 23: Hypothyroidism 24: Osteoporosis 25: Type 1 diabetes 26: Type 2 diabetes and diabetic foot problems Part 4 Gastrointestinal:John Creamer, David Fisher, Prabhsimran Singh: 27: Acute upper gastrointestinal bleeding and variceal bleeding 28: Coeliac disease 29: Crohn s disease 30: Gastro-oesophageal reflux disease and dyspepsia 31: Irritable bowel syndrome 32: Ulcerative colitis Part 5 Hepatobiliary:Tom Owens, Catharine Pearce, Vanessa Jessop, John Creamer: 33: Acute liver failure 34: Alcohol-related liver disease 35: Alcohol use disorders 36: Liver cirrhosis Part 6 Mental health:Sarah Orr, George Blanchard, Thomas McCabe: 37: Bipolar disorder 38: Depression 39: Eating disorders 40: Generalized anxiety disorder 41: Panic disorder 42: Post-traumatic stress disorder 43: Psychosis and schizophrenia 44: Self-harm 45: Violence and aggression Part 7 Nephrology:Mohammed Al-Talib, Catharine Pearce, Nicola West: 46: Acute kidney injury 47: Chronic kidney disease 48: Hyperkalaemia Part 8 Neurology:Angharad Everden, Bina Patel, Catharine Pearce, Ann Maria Albert, Nicola West, Stephanie Choo: 49: Acute encephalitis 50: Epilepsy 51: Headache 52: Meningitis 53: Metastatic spinal cord compression 54: Neuropathic pain 55: Parkinson s disease 56: Stroke and transient ischaemic attack Part 9 Obstetrics and gynaecology:Emma Shephard, Georgina Clark, Yasmin Smith, Harriet Gardner: 57: Antenatal care 58: Antepartum haemorrhage 59: Diabetes in pregnancy 60: Ectopic pregnancy and miscarriage 61: Hypertension in pregnancy 62: Intrapartum care 63: Nausea and vomiting in pregnancy 64: Pelvic organ prolapse in women 65: Postpartum haemorrhage 66: Sepsis in and following pregnancy 67: Thrombosis and embolism during pregnancy and the postnatal period 68: Urinary incontinence in women Part 10 Paediatrics:Clemency Nye, Liora Wittner, Samantha Williamson, Shervin Poladi, Ann Maria Albert: 69: Child maltreatment 70: Fever in under 5s 71: Neonatal infections 72: Paediatric asthma 73: Paediatric bacterial meningitis and meningococcal septicaemia 74: Paediatric bronchiolitis 75 : Paediatric diabetic ketoacidosis 76: Paediatric gastroenteritis 77: Paediatric type 1 diabetes 78: Paediatric urinary tract infections Part 11 Respiratory:Angharad Everden, Matthew Sutton: 79: Acute oxygen therapy 80: Asthma 81: Chronic obstructive pulmonary disease 82: Pleural effusion 83: Pneumonia Part 12 Rheumatology and musculoskeletal:Liora Wittner, Laura Brodie, Adam Maxwell, Clemency Nye, Harriet Blundell, Alison Hare: 84: Giant cell arteritis 85: Gout 86: Hot swollen joint 87: Low back pain and sciatica 88: Osteoarthritis 89: Polymyalgia rheumatica 90: Rheumatoid arthritis 91: Spondyloarthritis Part 13 Surgery:Darryl Bernstein: 92: Preoperative care 93: Postoperative care Part 14 Miscellaneous:Mohammed Al-Talib, Liora Wittner, James Andren, Gabriella Bathgate, Harriet Blundell: 94: Blood transfusion 95: Care of dying patients in the last days of life 96: Intravenous fluid therapy 97: Lower urinary tract symptoms in men 98: Venous thromboembolic diseases 99: Malaria Part 15 Cancer guidelines:Dinta Thakkar, Yasmin Smith, Mohammed Al-Talib, Clemency Nye, Elizabeth Tan, Ben Coombs, Ashwini Virgincar, Adam Maxwell, Gabriella Bathgate: 100: Brain and central nervous system cancers 101: Breast cancer 102: Childhood cancers 103: Gynaecological cancers 104: Haematological cancers 105: Head and neck cancers 106: Lower gastrointestinal cancers 107: Lung cancer 108: Sarcomas 109: Skin cancers 110: Upper gastrointestinal cancers 111: Urological cancers Part 16 Professional guidelines:Thomas McCabe, Vanessa Jessop, Gabriella Bathgate, Harriet Blundell: 112: Capacity and consent 113 Confidentiality: 114: DNACPR 115: Fitness to drive Part 17 Resuscitation:Tom Owens, Laura Brodie, Ashwini Virgincar, James Andren, Alison Hare, Sabrina Ahmed, Ben Coombs, Benjamin Bussman: 116: Advanced life support 117: Anaphylaxis and drug allergy 118: Bradycardia 119: Choking 120: Major trauma 121: Neutropenic sepsis 122: Sepsis 123: Tachycardia

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Book SynopsisMaximise your exam success with this essential revision guide.The fourth edition of Oxford Assess and Progress: Clinical Medicine, features over 600 Single Best Answer questions. Packed with new and updated questions written by experienced doctors, this revision tool is an authoritative guide for finals and the UKMLA.Questions on core clinical topics are accompanied by extensive feedback, which explains not only the rationale of the correct answer, but why the other options are incorrect. Further reading resources and updated cross-references to the eleventh edition of Oxford Handbook of Clinical Medicine expand your revision further.Progess to exam success with the fourth edition of Oxford Assess and Progress: Clinical Medicine.

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Book SynopsisDescribes the visible and palpable anatomy that forms the basis of clinical examination. This book considers the anatomical terms needed for precise description of the parts of the body and movements from the anatomical positions. It features colour photographs that demonstrate visible anatomy.Trade Review"An extraordinary work of art that in my opinion deserves a prize. Structures are shown on anatomical figures by means of numbers, or outlines in the case of bones, or coloured green or brown for other organs. The author says that one of the objects is to illustrate palpable anatomy that 'can be seen, felt, moved or listened to' and should be 'supplemented by self examination.'" BMA Book Awards 2009 - judges commentsTable of ContentsIntroduction. Head. Neck. Thorax. Abdomen and pelvis. Back. Upper limb. Lower limb.

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Book SynopsisFollowing the familiar, easy-to-use at a Glance format, OSCEs at a Glance 2nd Edition is both a revision guide and a comprehensive introduction to objective structured clinical examinations for medical students.Trade Review“Following the familiar, easy-to-use at a Glance format, OSCEs at a Glance 2nd Edition is both a revision guide and a comprehensive introduction to objective structured clinical examinations for medical students.” (Kingbook73's Medical Ebook and Video Collection, 27 August 2014)Table of ContentsPreface 7 Preface to the first edition 7 Acknowledgements 9 Selected list of abbreviations 10 Part 1 Introduction Logical approach 1 The OSCE examination 12 2 The stable patient 14 3 Presenting 16 4 History and examination 18 Practical stations 5 Practical stations 1 20 6 Practical stations 2 22 7 Practical stations 3 24 8 Practical stations 4 27 Communication stations 9 Communication stations 1 30 10 Communication stations 2 32 11 Communication stations 3 34 12 Communication stations 4 36 Emergency stations 13 Emergency stations 1 38 14 Emergency stations 2 41 Part 2 Medicine Cardiovascular 15 Cardiology stations: History 44 16 Cardiology stations: Examination 46 17 Cardiology stations: Cases 1 48 18 Cardiology stations: Cases 2 50 19 Cardiology stations: Cases 3 52 20 Cardiology stations: Skills 54 Respiratory 21 Respiratory stations: History 56 22 Respiratory stations: Examination 58 23 Respiratory stations: Cases 1 60 24 Respiratory stations: Cases 2 62 25 Respiratory stations: Cases 3 64 26 Respiratory stations: Cases 4 66 27 Respiratory stations: Skills 68 28 Respiratory stations: Data 1 70 29 Respiratory stations: Data 2 72 Abdominal 30 Abdominal stations: History 1 74 31 Abdominal stations: History 2 76 32 Abdominal stations: Examination 78 33 Abdominal stations: Cases 1 80 34 Abdominal stations: Cases 2 82 35 Abdominal stations: Cases 3 84 Neurology 36 Neurology stations: History 86 37 Neurology stations: Examination 1 88 38 Neurology stations: Examination 2 90 39 Neurology stations: Examination 3 92 40 Neurology stations: Examination 4 94 41 Neurology stations: Cases 1 96 42 Neurology stations: Cases 2 98 43 Neurology stations: Cases 3 100 44 Neurology stations: Cases 4 102 45 Neurology stations: Cases 5 104 46 Neurology stations: Cases 6 106 Endocrine 47 Endocrine stations: History 108 48 Endocrine stations: Examination 110 49 Endocrine stations: Cases 1 112 50 Endocrine stations: Cases 2 114 51 Endocrine stations: Cases 3 116 52 Endocrine stations: Cases 4 118 Part 3 Surgery General surgery 53 Surgical history 120 54 Surgical abdominal examination 122 55 Surgery cases 1: Abdomen 124 56 Surgery cases 2: Groin 126 57 Surgery cases 3: Neck 128 58 Surgery cases 4: Breast 130 59 Surgery cases 5: Lumps and bumps 132 60 Surgical skills 134 61 Surgical data interpretation 136 Vascular 62 Vascular history 138 63 Peripheral vascular examination 140 64 Vascular cases 142 Urology 65 Urological history 144 66 Urology examination and skills 146 Musculoskeletal 67 Musculoskeletal stations: History 148 68 Musculoskeletal stations: Examination 1 150 69 Musculoskeletal stations: Examination 2 152 70 Musculoskeletal stations: Examination 3 154 71 Musculoskeletal stations: Cases 1 156 72 Musculoskeletal stations: Cases 2 158 73 Musculoskeletal stations: Cases 3 160 74 Musculoskeletal stations: Cases 4 162 75 Musculoskeletal stations: Cases 5 164 76 Musculoskeletal stations: Data 166 Part 4 Specialties Paediatrics 77 Paediatric stations: History 168 78 Paediatric stations: Cardiology 170 79 Paediatric stations: Respiratory 172 80 Paediatric stations: Gastrointestinal 174 81 Paediatric stations: Infectious diseases 1 176 82 Paediatric stations: Infectious diseases 2 178 83 Paediatric stations: Neonatology 180 84 Paediatric stations: Child development 182 Obstetrics and gynaecology 85 Obstetrics and gynaecology stations: History and examination 1 184 86 Obstetrics and gynaecology stations: History and examination 2 186 87 Obstetrics and gynaecology stations: Cases 1 188 88 Obstetrics and gynaecology stations: Cases 2 190 89 Obstetrics and gynaecology stations: Cases 3 192 90 Obstetrics and gynaecology stations: Cases 4 194 91 Obstetrics and gynaecology stations: Cases 5 196 92 Obstetrics and gynaecology stations: Cases 6 198 93 Obstetrics and gynaecology stations: Cases 7 200 94 Obstetrics and gynaecology stations: Cases 8 202 95 Obstetrics and gynaecology stations: Cases 9 204 96 Obstetrics and gynaecology stations: Skills 1 206 97 Obstetrics and gynaecology stations: Skills 2 208 98 Obstetrics and gynaecology stations: Data 210 Dermatology 99 Dermatology stations: History 212 100 Dermatology stations: Examination 214 101 Dermatology stations: Cases 1 216 102 Dermatology stations: Cases 2 218 103 Dermatology stations: Cases 3 220 104 Dermatology stations: Cases 4 222 105 Dermatology stations: Cases 5 224 106 Dermatology stations: Skills and data 226 Ophthalmology 107 Ophthalmology stations: History and examination 228 108 Ophthalmology stations: Cases 1 230 109 Ophthalmology stations: Cases 2 232 110 Ophthalmology stations: Cases 3 234 111 Ophthalmology stations: Skills 236 ENT 112 ENT stations: History and examination 1 238 113 ENT stations: History and examination 2 240 114 ENT stations: History and examination 3 241 115 ENT stations: Cases 242 116 ENT stations: Skills and data 244 Psychiatry 117 Psychiatry stations: History 246 118 Psychiatry stations: Examination 248 119 Psychiatry stations: Cases 1 250 120 Psychiatry stations: Cases 2 252 121 Psychiatry stations: Cases 3 254 122 Psychiatry stations: Cases 4 256 Index of OSCE stations 259 Companion website A companion website is available at: www.ataglanceseries.com/osces featuring downloadable OSCE station checklists.

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Book SynopsisTable of ContentsIntroduction Rationale of the SJT The 5 question domains The two different question styles: ranking and multiple choice The scoring matrix used 2. Preparing for the SJT Good Medical Practice (2013). GMC Tomorrow's Doctors GMC Confidentiality GMC Consent (2008). GMC Mental Capacity Act (2005) Mental Health Act Common Law Financial and Commercial Recommendations (2013). GMC The Driver and Vehicle Licencing Agency (DVLA) and Your Duties as a Doctor (2009) Fitness to practise Raising concerns and whistle blowing Use of social media 3. Top Tips to Mastering the SJT Pre-revision revision Understand the role, expectations and limitations of a Foundation Year 1 Doctor. Patient-centred care Escalation Ladder Understand the subtext of the question Disclosing confidential information Professionalism Confrontation Information, Information, Information When in Doubt ...? 4. Domain 1 - Commitment to Professionalism Qualities and expected knowledge for this domain. What to expect the questions to focus on. 50 practice questions, with explanations. (35 ranking-style questions and 15 MCQs). Scoring matrix. 5. Domain 2 - Coping with Pressure Qualities and expected knowledge for this domain. What to expect the questions to focus on. 50 practice questions, with explanations. (35 ranking-style questions and 15 MCQs). Scoring matrix. 5. Domain 3 - Effective Communication Qualities and expected knowledge for this domain. What to expect the questions to focus on. 50 practice questions, with explanations. (35 ranking-style questions and 15 MCQs). Scoring matrix. 6. Domain 4 - Patient Focus Qualities and expected knowledge for this domain. What to expect the questions to focus on. 50 practice questions, with explanations. (35 ranking-style questions and 15 MCQs). Scoring matrix. 7. Domain 5 - Working Effectively as Part of a Team Qualities and expected knowledge for this domain. What to expect the questions to focus on. 50 practice questions, with explanations. (35 ranking-style questions and 15 MCQs). Scoring matrix

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Book SynopsisEssential Primary Care aims to provide undergraduate students with a comprehensive overview of the clinical problems encountered in primary care. It covers the structure of primary care in the UK, disease prevention and the management of common and important clinical presentations from infancy to old age.Table of Contentscontributors viii Foreword ix Preface x How to use your textbook xi About the companion website xii Part 1: The key features of primary care 1 The structure and organisation of primary care 3Andrew Blythe 2 The GP consultation 10Jessica Buchan 3 Making a diagnosis 22Barbara Laue 4 Prescribing 30Andrew Blythe 5 The interface with secondary care 42Sarah Jahfar 6 The everyday ethics of primary care 50Trevor Thompson Part 2: Healthy living and disease prevention 7 Behaviour change 59Jessica Buchan 8 Alcohol and drug misuse 68Andrew Blythe 9 Preventing cardiovascular disease 77Andrew Blythe 10 Caring for people with learning disabilities 85Andrew Blythe Part 3: Common presenting problems 11 Tiredness 95Andrew Blythe Childhood 12 Child health in primary care 111Jessica Buchan 13 Managing the feverish and ill child in primary care 120Alastair Hay, Lucy Jenkins and Jessica Buchan 14 Managing common conditions in infancy 134Jessica Buchan 15 Managing chronic conditions in childhood 139Lucy Jenkins, Alastair Hay, Matthew Ridd and Jessica Buchan 16 Teenage and young]adult health 147Jessica Buchan and David Kessler Early adulthood 17 Respiratory tract infections 157Lucy Jenkins 18 Low back pain 163Jessica Buchan 19 Heartburn and dyspepsia 170Jessica Buchan 20 Diarrhoea and rectal bleeding 177Andrew Blythe 21 Common skin conditions 184Matthew Ridd 22 Headache 194Andrew Blythe 23 Fits, faints and funny turns 201Andrew Blythe 24 Depression, anxiety and self]harm 210David Kessler 25 Sexual health and dysuria 219Lucy Jenkins 26 Menstrual problems, contraception and termination of pregnancy 231Jessica Buchan 27 Pregnancy 241Jessica Buchan 28 Domestic violence and abuse 254Gene Feder Middle and old age 29 Cardiovascular disease 265Andrew Blythe 30 Breathlessness 275Jessica Buchan 31 Joint pains and stiffness 287Andrew Blythe 32 Urinary problems and prostate disease 294Simon Thornton 33 The menopause 302Jessica Buchan 34 Multimorbidity and polypharmacy 307Polly Duncan and Andrew Blythe 35 Falls and fragility fractures 314Andrew Blythe 36 Visual and hearing loss 322Andrew Blythe 37 Dementia 331Andrew Blythe Part 4: Cancer 38 Spotting patients with cancer 343Andrew Blythe 39 Looking after patients with cancer 352Andrew Blythe Part 5: Palliative care and death 40 Palliative care and death 361Andrew Blythe Index 371

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Book SynopsisTable of ContentsPreface Foreword 1. Neurology Worldwide: Public Health & Essential Neuro-epidemiology 2. Movement, Sensation & The Silent Brain 3. Aetiologies & Mechanisms: Genetics, Immunology & Ion Channels 4. Examination, Diagnosis & The Language of Neurology 5. Cognition, Cortical Function & Dementias 6. Stroke & Cerebrovascular Disease 7. Movement Disorders 8. Epilepsy & Related Disorders 9. Infection & the Nervous System 10. Nerve, Anterior Horn Cell & Muscle Disease 11. Multiple Sclerosis, Devic’s & other Demyelinating Diseases 12. Headache 13. Cranial Nerve Disorders 14. Neuro-Ophthalmology 15. Neuro-Otology: Disorders of Balance & Hearing 16. Spinal Cord & Spinal Column 17. Ataxias, Cerebellar Disorders & Related Conditions 18. Restorative Neurology, Rehabilitation & Brain Injury 19. Toxins, Physical Insults, Nutritional & Metabolic Disorders, Unregulated Drugs 20. Consciousness, Coma, Intensive Care & Sleep 21. Neuro-Oncology 22. Neuropsychiatry: an introduction 23. Pain 24. Autonomic Aspects of Neurology 25. Uro-Neurology & Sexual Dysfunction 26. Systemic Conditions & Neurology Index

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Book SynopsisInoculate yourself againstthe confusion and misinformation surrounding vaccines Measles, mumps, and rubellaoh my!Why are we vaccinating our childrenand ourselvesagainstthese diseases, and what goes on inourbodies after the needlecomes out?Vaccines For Dummieswill inform and entertain you about allthingsvax, including how the first vaccines were discovered, what's in modern vaccines,how they aretested andapprovedfor use, and whytheCDC's vaccine schedule is what it is.Inside,you'llalso find a complete guide tovaccinebenefits,potential side effects,and contraindications, so you'll be readywhen shottime comes. Fromthe very firstinoculationshundreds of years ago to the brandnewCOVID-19 shot, creating immunity to diseases has become a human specialty.Ifyou'rewondering how safe and how necessary it all is, you aren't alone. InVaccinesForDummies,we'll explorethe issue from every angle, empowering you to take charge of your wellbeing.With this book, you will: Discoverthe ABCs of vaccines, including whatthey'remade of and how they workLearn abouteach recommended childhoodand adultimmunization, plus the seasonal flu shot, all with this evidence-based guideTake a journey through vaccine history,meeting the major players ofyesterday and todayDecide what's right for your family, with the help of the most recent vaccine science Parents,parents-to-be,adults of any age,and anyone who wants to delve into the microscopic world of pathogens and theirarch nemeses(antigens and antibodies)willget a doubledose of knowledge fromVaccinesForDummies.Table of ContentsIntroduction 1 About This Book 1 Foolish Assumptions 2 Icons Used in This Book 2 Beyond the Book 2 Where to Go from Here 3 Part 1: Getting Started with Vaccine Basics 5 Chapter 1: Focusing on Vaccine Fundamentals 7 Realizing the Crucial Role of Vaccines 8 Explaining How a Vaccine Works 9 Distinguishing between antigens and antibodies 10 Breaking down other vaccine ingredients 10 Comparing Viruses, Bacteria, and Toxins 11 Studying COVID-19 Vaccine Development 14 Understanding the Importance of Vaccine Schedules 15 Preparing for Potential Vaccine Side Effects 16 Optimizing Your Immune Response 16 Chapter 2: The (Non) Life of a Virus 17 Looking Inside Your Average Virus 18 Investigating Influenza Viruses 18 Type A 19 Type B 21 Type C 21 Type D 22 Examining Enteroviruses (Including Rhinoviruses) 22 Knowing About Norovirus 23 Understanding HIV 24 Trying to Say Goodbye to Measles 25 Checking Out the Cause of Chicken Pox: Varicella 26 Fighting Ebola 27 Surveying Variola (Smallpox) 29 Chapter 3: The Crowned Virus: Coronavirus 31 Identifying the Coronavirus in Humans 32 Combatting the Common Cold Coronavirus 33 What is a cold, exactly? 34 What causes a cold? 34 When is a cold not a cold? 35 Surveying SARS and MERS 40 Severe acute respiratory syndrome (SARS) 40 Middle East respiratory syndrome (MERS) 41 COVID-19: The Novel (and Specially Confounding) Coronavirus 42 Reviewing the start of the pandemic 42 Charting the course of the infection 44 Detecting a COVID-19 infection 46 Digging into the development of COVID-19 vaccines 50 Dealing with vaccine side effects 52 Aiming for herd immunity 53 Keeping safe from COVID-19 if you’re not yet protected by vaccination 55 Coping with COVID-19 and flu season 56 Chapter 4: Bacterial Bad Guys 57 Understanding What Makes Bacteria Different from Viruses 57 Digging into Vaccines That Defuse Bacteria 58 The make-up of vaccines that protect against bacterial toxins 59 The bacterial illnesses that vaccines prevent 59 Comparing Antibiotics and Vaccines 64 Seeing How Vaccines Help Prevent Antibiotic Resistance 65 Part 2: Verifying Valuable Vaccines 67 Chapter 5: Distinguishing and Testing Different Vaccines 69 Getting to Know the Different Types of Vaccines 70 Whole-pathogen vaccines 70 Subunit vaccines 72 Testing Vaccines for Safety and Effectiveness 75 Determining the need and costs: The preclinical stage 75 Phase I 76 Phase II 76 Phase III 76 Post–Phase III 77 Studying the Efficacy of Vaccines 78 Measuring efficacy versus effectiveness 78 Rounding up herd immunity 79 Tracing the History of Various Vaccines 80 Smallpox 80 Typhoid fever 81 Yellow fever 81 Influenza 82 Polio 82 Anthrax 82 Measles, mumps, and rubella (MMR) 82 Varicella (chicken pox) 83 Chapter 6: Tracking the Current List of Effective Vaccines 85 Chicken Pox (Varicella) 85 Diphtheria, Tetanus, and Pertussis 86 Diphtheria 86 Tetanus 87 Pertussis 88 Haemophilus Influenzae Type B (Hib) 88 Hepatitis A 89 Hepatitis B 90 Human Papillomavirus (HPV) 92 Influenza (Flu) 93 Measles, Mumps, and Rubella (MMR) 95 Measles, Mumps, Rubella, and Varicella (MMRV) 97 Meningococcal Vaccines 97 Pneumococcal Vaccines 98 For adults 99 For children 100 Rotavirus 101 Shingles (Herpes Zoster) 102 Chapter 7: What to Expect When You’re Vaccinating 105 Understanding Side Effects: What May Cause Them and What Happens 106 Looking at common vaccine ingredients 106 Distinguishing vaccine delivery methods 110 Watching for localized skin reactions 111 Expecting a systemic immune response 114 Recognizing and Treating Serious Reactions 116 Avoiding allergic reactions 117 Anaphylactic reactions 117 Febrile seizures after childhood vaccinations 118 Guillain-Barré syndrome 119 Thrombocytopenia 120 Looking at Multiple Vaccines and the Immune System 120 Part 3: Scheduling Safety 123 Chapter 8: Vaccines for Children 125 Understanding Mom-to-Baby Immunity 125 Breastfeeding benefits 126 Antibodies passed on during pregnancy 126 Getting a Reminder of the Effectiveness and Importance of Vaccinations 127 Focusing on Vaccinations in the First Year of Life 127 Hepatitis B 128 Rotavirus 129 DTaP (Diphtheria, tetanus, pertussis) 131 Hib 132 IPV (inactivated polio vaccine) 132 Influenza 133 PCV13 134 Knowing New Vaccinations for Toddlers 134 MMR (measles, mumps, rubella) 136 Varicella or MMRV 139 Hepatitis A 140 Surveying a Few Vaccines for Ages 4 to 6 140 Adding Some School-Age Vaccinations 141 Human papillomavirus (HPV) 141 Meningococcal conjugate (MenACWY) 142 Tetanus, diphtheria, and pertussis (Tdap) 142 Needing a Booster: Vaccines for Teens 143 Catching Up on Childhood Vaccines 144 Spreading vaccines out 144 Starting vaccines late 144 Adopting a child from another country 145 Checking Out Vaccine Schedules Around the World 146 Chapter 9: Vaccines for Adults 147 Vaccines When You’re 19–26 Years Old 147 Your yearly flu shot 148 The COVID-19 vaccine 149 A Tdap or Td booster 150 Vaccines When You’re 27–49 Years Old 151 Vaccines When You’re 50–64 Years Old 151 Vaccines When You’re 65-Plus Years Old 153 Influenza 153 Tdap 155 Pneumococcal vaccines 156 Vaccines Before and During Pregnancy 156 Vaccines for Travelers 157 Making sure you’re up to date on routine vaccines 158 Getting other vaccines depending on your destination 158 Catching Up: If Your Parents/Guardians Didn’t Vaccinate You 160 Chapter 10: Spelling Out Who May Face Risks 161 Knowing When to Avoid or Limit Vaccines 161 Considering vaccines and cancer 162 Vaccines and immune disorders 163 Vaccines after organ transplantation 164 Understanding Vaccines and Allergies 165 Allergies to vaccine ingredients and components 165 Different types of reactions 168 Recognizing reactions that actually aren’t allergies 169 Taking precautions before vaccination 169 Assessing Reactions to the COVID-19 Vaccine 170 Rare cases of anaphylaxis 170 Other types of reactions 170 Inspecting ingredients found in current COVID-19 vaccines 171 Getting the COVID-19 vaccine after you’ve had COVID-19 173 Chapter 11: Anti-Vaxxers and Debunking Myths About Vaccines 175 Studying the Rise of Vaccine Hesitancy 176 Understanding why some people don’t vaccinate 176 Looking at the early anti-vaxxers 178 Debunking Common Vaccine Myths 179 Myth: Diseases were disappearing before vaccines were invented 180 Myth: Vaccines cause serious side effects, illnesses, and death 180 Myth: Kids don’t need to be vaccinated so young 181 Myth: Kids don’t need to be vaccinated when illnesses don’t exist in their country 184 Myth: Giving multiple vaccines at the same time overloads the immune system 184 Myth: Vaccines can cause the disease they are supposed to prevent 185 Myth: Not getting vaccinated affects only me 186 Myth: Natural immunity is always best 186 Myth: The MMR vaccine causes autism 187 Myth: Vaccines contain harmful chemicals 188 Reviewing Vaccine Recalls 189 Part 4: The Part of Tens 191 Chapter 12: Five People Who Created Ten (Or More) Modern Vaccines 193 Edward Jenner: Snuffing Out Smallpox 193 Louis Pasteur: Ridding the World of Rabies 194 Jonas Salk and Albert Sabin: Putting Polio Behind Us 195 Maurice Hilleman: The Master of Modern Vaccines 196 Chapter 13: Ten Diseases Without Vaccines, from A to Z 199 Avian Influenzas (Bird Flu) 200 Cytomegalovirus (CMV) 200 Epstein-Barr Virus (EBV) 201 Hepatitis C 202 Herpes Simplex Virus (HSV) 1 and 2 203 HIV/AIDS 204 Lyme Disease 205 Respiratory Syncytial Virus (RSV) 207 West Nile Virus 208 Zika Virus 209 Chapter 14: The Ten Most Lethal Major Pandemics 211 Antonine Plague (165–180) 212 Plague of Justinian (541–750) 212 Bubonic Plague (Black Death) (1346–1353) 213 Cholera (1846–1860) 214 Third Plague Pandemic (1855–1960) 215 Influenza (Russian Flu) (1889–1890) 215 Influenza (Spanish Flu) (1918–1919) 216 Influenza (Asian Flu) (1957–1958) 217 Human Immunodeficiency Virus (HIV) (1981–Present) 217 COVID-19 (2020–Present) 218 Chapter 15: Ten Ways to Boost Your Immune System 219 Getting Your Vaccinations 219 Decreasing Stress 220 Eating Well 220 Maintaining a Healthy Weight 221 Getting Enough Sleep 221 Exercising for Immunity 222 Saying No to Smoking 222 Drinking Only in Moderation 223 Staying Connected 223 Considering Supplements 224 Index 225

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Book SynopsisAttaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter through better science, better clinical care, better training, better responsiveness to communities, and better stewardship and leadership in the health professions. This concise, easy to read title consists of mini chapters intended as a resource to assist early- and middle-career physicians, clinicians, and scientists in understanding the unique mission of academic medicine and building creative, effective, and inspiring careers in academic health organizations. Organized in eight sections, the Guide covers such areas as finding your path in academic medicine, getting established at an institution, approaching work with colleagues, writing and reviewing manuscripts, conducting empirical research, developing administrative skills, advancing your academic career, and balancing your professional and personal life. Each chapter i

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Book SynopsisThis instant gold standard title is a major contribution to the field of clinical medical ethics and will be used widely for reference and teaching purposes for years to come. Throughout his career, Mark Siegler, MD, has written on topics ranging from the teaching of clinical medical ethics to end-of-life decision-making and the ethics of advances in technology. With more than 200 journal publications and 60 book chapters published in this area over the course of his illustrious career, Dr. Siegler has become the pre-eminent scholar and teacher in the field. Indeed his work has had a profound impact on a range of therapeutic areas, especially internal medicine, pediatrics, surgery, oncology, and medical education.Having grown steadily in importance the last 30 years, clinical ethics examines the practical, everyday ethical issues that arise in encounters among patients, doctors, nurses, allied health workers, and health care institutions. The goal of clinical ethics is to improve patient care and patient outcomes, and almost every large hospital now has an ethics committee or ethics consultation service to help resolve clinical ethical problems; and almost every medical organization now has an ethics committee and code of ethics. Most significantly, clinical ethics discussions have become a part of the routine clinical discourse that occurs in outpatient and inpatient clinical settings across the country. This seminal collection of 46 landmark works by Dr. Siegler on the topic is organized around five themes of foundational scholarship: restoring and transforming the ethical basis of modern clinical medicine, the doctor-patient relationship, education and professionalism, end-of-life care, and clinical innovation. With introductory perspectives by a group of renowned scholars in medicine, Clinical Medical Ethics: Landmark Works of Mark Siegler, MD explains the field authoritatively and comprehensively and will be of invaluable assistance to all clinicians and scholars concerned with clinical ethics. Table of ContentsContentsPart I Restoring and Transforming the Ethical Basis of Modern Clinical Medicine1 An Introduction from Laura Weiss Roberts, M.D., M.A.2 A Perspective from Mark Siegler, M.D.3 A Perspective from Daniel P. Sulmasy, M.D., Ph.D.4 A Perspective from Dana Levinson, M.P.H., Holly J. Humphrey, M.D., and Kenneth S. Polonsky, M.D.5 A Perspective from Jordan J. Cohen, M.D.6 A Perspective from Peter A. Singer, M.D.Part II Landmark Works on Clinical Medical Ethics by Mark Siegler, M.D.7 Foundational Scholarship7.1 Clinical ethics and clinical medicine (1979)Mark Siegler7.2 Decision-making strategy for clinical ethical problems in medicine (1982)Mark Siegler7.3 An ethics consultation service in a teaching hospital. Utilization and evaluation (1988)John La Puma, Carol B. Stocking, Marc D. Silverstein, Andrea DiMartini, Mark Siegler7.4 Clinical medical ethics (1990)Mark Siegler, Edmund D. Pellegrino, Peter A. Singer7.5 Ethics committees and consultants (1990)Peter A. Singer, Edmund D. Pellegrino, Mark Siegler7.6 Future directions in clinical ethics (1991)Edmund D. Pellegrino, Mark Siegler, Peter A. Singer7.7 Clinical ethics (1991)Mark Siegler, Peter A. Singer7.8 Clinical ethics in the practice of medicine (1996)Peter A. Singer, Mark Siegler7.9 Five major themes in bioethics (1997)Lainie Friedman Ross, Mark Siegler7.10 The contributions of clinical ethics to patient care (1997)Mark Siegler8 The Doctor-Patient Relationship8.1 Searching for moral certainty in medicine: a proposal for a new model of the doctor-patient encounter (1981)

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Book SynopsisThis book is the latest volume in the series presenting clinicians and medical students with the latest advances in medicine, with emphasis on endocrine and cardiovascular disorders. Presented as a collection of articles, the first chapters provide an overview of the field and discussion on medical teaching. The following sections cover the diagnosis and management of numerous conditions in everyday clinical practice. Separate chapters explore advances in other sub-specialties such as kidney disease, sepsis and asthma, and several complete sections are dedicated to Covid and associated disorders. Enhanced by clinical photographs and figures, this valuable text serves as a ready reckoner for different approaches to clinical case management. The previous volume (9789389587111) published in 2020.Table of Contents Combating Physician Burnout Is Clinical Medicine a Forgotten Art? Pedagogy in Medicine – How to be an Expert Medical Educator – Evidence-based Review Acute Rheumatic Fever Angiotensin Receptor Blocker & Angiotensin Converting Enzyme Inhibitors – Newer Insights Subclinical Hyperthyroidism Approach to Sleep Apnoea Jaundice in Pregnancy CMBCD (Cardio Metabolic Based Chronic Disease) Endocrine Hypertension GINA - Global Initiative for Asthma Heart Rate - An Independent Risk Factor & the PROFICIENT Study Hypertensive Emergencies Hyponatremia in the Intensive Care Unit Importance of Influenza Vaccination in Adult Population Interpreting the Link between Hyperuricemia and Cardiometabolic Disorders and Management Masked Hypertension: How Worrisome? Myelodysplastic Syndrome (MDS): What a Physician Should Know? Approach to Metabolic Syndrome Non Alcoholic Fatty Liver Disease (NAFLD) – What’s in the Name? Vagal Nerve Stimulation (VNS) and Baroreceptor Activation Therapy (BAT) - An Emerging Modality for Refractory Heart Failure A Century of Basal Glucose Regulation Pyrexia of Unknown Origin Evolving Epidemiology of Covid, Clinical Presentation & Triage Covid-19 and Diabetes Mellitus Digital Outreach: Reaching the Unreached Asthma, Biologics & Clinical Pharmacology An Approach to Diabetic Autonomic Neuropathy Pharmacokinetic Considerations in Prescribing Chronic Kidney Disease Patients Protection of the Healthcare Workers (HCWs) in the Covid Pandemic The Immunology of Sepsis Covid & Cardiovascular System Nutrition in Diabetes: Relevance and Current Evidence

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Book SynopsisHow digital therapies can transform your health. Traditional health care has a new ally. Some patients with sleep disorders, back pain, and diabetes are now being prescribed app-based treatment instead of drugs. Algorithms are helping cancer patients manage their symptoms, and video games are improving the attention span of children diagnosed with ADHD. A new class of medicine called digital therapeutics (DTx) is gaining traction and transforming the way patients engage with the health care system. In Medicine without Meds, Dean Ho, Yoann Sapanel, and Agata Blasiak explore the exciting potential for these digital therapies to transform patient care. Ho, Sapanel, and Blasiak share their insights on how these therapies can deliver value beyond the technology, address the challenges of implementation in existing health care models, and revolutionize care delivery. These clinicians, researchers, engineers, patients, start-up founders, and corporate executives are at the forefront of deTrade ReviewThis book shares useful resources, discusses insightful case studies (both successful and unsuccessful), and provides guidelines at various technology and business development stages. The case studies and key takeaways are particularly instrumental and enjoyable to read. The international coverage of the topic is another highlight of the book. I consider the book highly original, and it represents a substantial contribution to the digital therapeutic space. It should be a must-read.—Pak Kin Wong, PhD, The Pennsylvania State UniversityTable of ContentsForewordD. A. WallachPrefaceIntroduction. The ContextPart I. What Are Digital Therapeutics?Chapter 1. Digital Health Solutions versus Digital TherapeuticsPart II. The Right Tool for the Right ProblemChapter 2. Addressing Unmet Stakeholder NeedsChapter 3. Addressing Unmet Clinical NeedsChapter 4. Ensuring Business Viability EarlyChapter 5. Test, Learn, and PivotPart III. From Pilot to ProductionChapter 6. Data Sourcing and ManagementChapter 7. Clinical Validation: Unique Challenges and Novel ApproachesChapter 8. Factors That Influence the Implementation of New TechnologiesChapter 9. Recommendations for DTx ImplementationChapter 10. Supporting Adoption of DTxPart IV. Paths to CommercializationChapter 11. Channel Partnerships: The Ultimate Commercialization StrategyChapter 12. The Price Is Right: Value in the Eye of the BeholderConclusion. The Future of DTxWith Dr. Eddie MartucciAcknowledgmentsAppendix A. AI and Its Potential Use in DTx: A Brief Overview of Frequently Asked QuestionsAppendix B. How to Translate Evidence-Based Theories to the Design of Digitally Delivered Mental Health InterventionsBibliographyIndex

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Book SynopsisAdverse reactions to medicines continue to present a considerable burden on healthcare, causing considerable morbidity and mortality. As well as knowing about the benefits of medicines, healthcare professionals need to understand the problem of adverse drug reactions and be aware of how they can be prevented and managed.Trade Review'this book should be kept on the shelf to be used for frequent reference by professionals in primary care...while detailed in places...it is extremely readable and contains enough breadth to make it suitable for those who are visiting the topic for the first time.' Journal of Advanced Nursing 57, 01-Oct-06 * Journal of Advanced Nursing *Table of ContentsIntroduction to adverse drug reactions and pharmacovigilance: Melinda Cuthbert;Side effects and patients: Sheila C Noble;Pharmacogenetics: Munir Pirmohamed, Victoria Rollinson;Pregnancy: Jane Bass, Matthew Caldwell, Sophie Lumley, Catherine Nelson-Piercy, Nanda Surabhi ;Drug-induced cutaneous reactions: David Clifford, Sylwia Michlewska, Joanna Skwarski;Gastrointestinal system: Benjamin Kelly Hannan, Lynne Michelle Merchant, Duncan James Wilson;Hepatic disorders: Robbie Cord;Renal disorders: Aileen Dunleavy;Endocrine disorders: Yvonne Clark; Elaine McIvor;Respiratory disorders: Fiona McTaggart, Jenny Scott;Musculoskeletal disorders: Christine Randall;Blood disorders: Kelly Baillie;Mental health disorders: Anne Lee;Cardiovascular effects: Aaron Linstead;Neurological disorders: Fiona Needleman;Sexual dysfunction and infertility: Sherry A Wright, Joo Thong;

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Book SynopsisPharmacy OSCEs is the only pharmacy-specific OSCE revision guide. This easy-to-use book covers the key competencies that will be tested during your Objective Structured Clinical Examinations whether you are still studying or in practice.Table of Contents1. Responding to symptoms and history-taking; 2. Systems-based client assessment; 3. Legal aspects of prescriptions, and record-keeping; 4. Data retrieval and interpretation; 5. Clinical prescription management problems; 6. General health advice; 7. Counselling (medication and devices); 8. Problems involving calculations.

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Book SynopsisTable of ContentsPreface to the Fourth Edition xiii List of Contributors xvii 1 Introduction 1 Nicholas Mays and Catherine Pope 1.1 What Is Qualitative Research? 1 1.2 The Uses of Qualitative Research 4 1.3 Methods Used in Qualitative Research 6 1.4 The Place of Qualitative Methods in Health Care Research 7 1.5 Outline of the Structure of the Book 9 References 10 Further Reading 13 2 The Role of Theory in Qualitative Research 15 Catherine Pope and Nicholas Mays 2.1 Introduction 15 2.2 Differences in Ontology and Epistemology 16 2.3 Implications of Ontology and Epistemology 18 2.4 Choose Your Philosophical Umbrella – Positivism or Interpretivism? 19 2.5 Theoretical Perspectives 21 2.6 Methodology 24 References 25 Further Reading 26 3 Ethical Issues in Qualitative Research 27 Dawn Goodwin, Nicholas Mays, and Catherine Pope 3.1 Introduction 27 3.2 Ethical Principles 28 3.2.1 Informed Consent 30 3.2.2 Confidentiality 31 3.2.3 Anonymity 34 3.3 Situational Ethics 35 3.4 Relational Ethics 38 3.5 Conclusion 39 References 40 Further Reading 41 4 Interviews 43 Lisa Hinton and Sara Ryan 4.1 Introduction 43 4.2 What Makes a Good Qualitative Interview? 46 4.3 Role of the Interviewer 47 4.4 The Practicalities of Qualitative Interviews 48 4.4.1 How Many Interviews Is Enough? 48 4.4.2 Sampling 49 4.4.3 Recruitment 50 4.4.4 Fundamentals – Quiet Space, Recording, and Transcription 51 4.4.5 Designing a Topic Guide 51 4.4.6 Data Saturation 52 4.5 Reflexivity 52 4.6 Conclusion 53 References 54 Further Reading 55 5 Focus Groups 57 Jonathan Q. Tritter and Bodil J. Landstad 5.1 Introduction 57 5.2 What Is a Focus Group? 58 5.3 Doing Focus Group Research 58 5.3.1 Recruitment and Sampling 59 5.3.2 Initiating the Focus Group 61 5.3.3 Follow‐on or Second Focus Groups 62 5.4 Analysis 62 5.5 Ethical Issues 63 5.6 Conclusion 64 References 64 Further Reading 66 6 Observational Methods 67 Catherine Pope and Davina Allen 6.1 Introduction 67 6.2 Observational Methods and Ethnography 68 6.3 Rationales for Observational Studies in Health Care Research 69 6.4 Practical Issues to Consider When Using Observational Methods 72 6.4.1 Ethical Issues 72 6.4.2 Access to the Field 72 6.4.3 Research Roles 73 6.4.4 Recording Observational Data 74 6.5 The Relationship Between Theory and Observational Research 76 6.6 Analysis 76 6.7 Quality in Observational Studies 77 References 78 Further Reading 81 7 Documentary Analysis 83 Martin Gorsky and Alex Mold 7.1 Introduction 83 7.2 Uses of Documentary Methods 84 7.3 Sources and Location 86 7.4 Selection, Recording, and Storing 89 7.5 Approaches to Analysis 90 7.6 Conclusion 93 References 94 Further Reading 96 8 Digital Data and Online Qualitative Research 97 John Powell and Michelle H. van Velthoven 8.1 Introduction 97 8.2 Types of Digital and Virtual Data 98 8.3 Who Goes Online? The Have‐Nets and the Have‐Nots 99 8.4 Using Existing Online Data for Qualitative Health Research 100 8.5 Eliciting Qualitative Data Using Online Methods 103 8.6 Big Data and Digital Qualitative Research 104 8.7 Ethics of Using Digital Data and Conducting Online Research 105 8.8 Conclusions 108 References 108 Further Reading 109 9 Analysis 111 Catherine Pope, Sue Ziebland, and Nicholas Mays 9.1 The Nature and Scale of Qualitative Data 111 9.2 Data Preparation 112 9.3 The Relationship Between Data and Analysis 113 9.4 Counting and Qualitative Data 114 9.5 Initial Steps in Analysis 116 9.6 Thematic Analysis 119 9.7 Grounded Theory 120 9.8 IPA 122 9.9 The ‘Framework’ Approach 123 9.10 Software Packages Designed to Handle Qualitative Data 124 9.11 Developing Explanations – The Role of the Researcher 126 9.12 Working in a Team 128 9.13 Conclusion 131 References 131 Further Reading 133 10 Conversation Analysis 135 Geraldine M. Leydon and Rebecca K. Barnes 10.1 Introduction 135 10.2 What Is CA? 135 10.3 What Kinds of Questions Can CA Be Used to Answer? 137 10.4 Collecting Naturalistic Data 137 10.5 Transcription 139 10.6 Analysis 141 10.7 Sharing CA to Inform Health Care Practice 144 10.8 Conclusion 145 10.9 Further Considerations for CA Research 146 References 146 Further Reading 150 11 Synthesising Qualitative Research 151 Nicholas Mays and Catherine Pope 11.1 Introduction 151 11.2 Should We Synthesise Qualitative Research at all? 152 11.3 The Purposes of Synthesis 153 11.4 Generic Issues in Qualitative Synthesis 154 11.4.1 Refining the Research Question and Search Strategy 154 11.4.2 Data Extraction 155 11.4.3 Quality Appraisal of Studies 156 11.4.4 Analysis and Interpretation 156 11.5 Methods for Synthesising Qualitative Research 157 11.5.1 Narrative Synthesis 157 11.5.2 Framework Synthesis 158 11.5.3 Qualitative Cross‐Case Analysis 158 11.5.4 Meta‐ethnography 159 11.6 Synthesis of Qualitative and Quantitative Evidence 160 11.6.1 Integrating at the Review Level 161 11.6.2 Integrating Using a Common Structure, Framework, or Model 161 11.6.3 Integrating Through ‘Transformation’ of Data 162 11.6.4 Using an Integrative Method 164 11.7 Conclusion 165 References 166 Further Reading 168 12 Mixed Methods Research 169 Alicia O’Cathain 12.1 Introduction 169 12.2 Dealing with the ‘Paradigm Wars’ 170 12.3 Getting to Grips with Mixed Methodology 170 12.4 Mixed Methods Study Designs 171 12.4.1 Evaluation 171 12.4.2 Survey and Interviews 173 12.4.3 Development of Questionnaires and Measures 173 12.5 Integration of Qualitative and Quantitative Data and Findings 174 12.6 Thinking About Quality 175 12.7 Team Working 176 12.8 Publishing 176 12.9 Conclusions 177 References 177 Further Reading 180 13 Case Studies 181 Alec Fraser and Nicholas Mays 13.1 Introduction 181 13.2 Types of Case Study Research 182 13.3 Practical Considerations for Using Case Study Approaches in Health Care Settings 184 13.3.1 Defining Cases 184 13.3.2 Sampling 185 13.3.3 Data Collection Methods 187 13.3.4 Analysis 188 13.4 Conclusions 189 References 189 Further Reading 191 14 Participatory Research in Health Care 193 Kath Maguire and Nicky Britten 14.1 Introduction 193 14.2 Co‐production 196 14.3 Participatory Action Research 199 14.4 Service User‐Controlled Research 201 14.5 Citizen Science 204 14.6 Conclusion 206 References 207 Further Reading 210 15 Quality in Qualitative Research 211 Nicholas Mays and Catherine Pope 15.1 Introduction 211 15.2 Can We Use the Same Quality Criteria to Judge Qualitative and Quantitative Research? 213 15.2.1 Qualitative and Quantitative Research are Separate and Different: The Anti‐Realist Position 214 15.2.2 It Is Possible to Assess Qualitative and Quantitative Research Using Similar Criteria: The Subtle Realist Position 216 15.3 Assuring and Assessing the Validity of Qualitative Research 216 15.3.1 Triangulation 217 15.3.2 Respondent Validation 218 15.3.3 Clear Exposition of Methods of Data Collection and Analysis 218 15.3.4 Reflexivity 219 15.3.5 Attention to Negative Cases 220 15.3.6 Fair Dealing 220 15.4 Relevance 221 15.5 The Appropriate Role for Quality Guidelines in Qualitative Research 222 15.5.1 Spencer and Colleagues’ Framework for Assessing the Quality of Qualitative Research Evidence 223 15.5.1.1 Guiding Principles 223 15.5.1.2 Appraisal Questions 224 15.5.1.3 Quality Indicators 224 15.5.1.4 The Framework 224 15.5.2 Additional Quality Assessment Criteria 224 15.5.2.1 Data Collection 224 15.5.2.2 Analysis 230 15.6 Conclusion 230 References 231 Further Reading 233 Index 235

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Book Synopsis

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