Biotechnology Books

Book SynopsisWhat do we owe our future children? How do advances in biomedical science bear on these obligations? How do capitalist incentives distort their execution? Advances in biotechnologies for human enhancement and designer babies appear to offer us new hope to control the fragility of human living. Some philosophers have argued that we have a moral imperative to use them, especially to eliminate disabilities. Elyse Purcell offers an opposing view, one guided by existential insights and Marxist reflections. Engineering Perfection: Solidarity, Disability, and Well-being explores the effect global capitalism may have on the selection of traits for our future children and how the commercialization of these technologies may lead to the elimination of bodily diversity. Although philosophers have addressed the possible widening between the haves and have-nots, this book considers the role oppression and exploitation may play in enhancing bodies for profit. As a challenge to the global economy of debility, Purcell proposes the Solidarity view, which embraces human vulnerability and embodied difference. By reflecting on facets of the human condition, the Solidarity view challenges us to reject our conception of the good life as human perfection, and instead reconceive of the good as one’s self-realization through the interdependent mutual recognition and co-belonging with others.Trade Review"In her monograph, Engineering Perfection: Solidarity, Disability, and Well‐being, Elyse Purcell weaves compelling stories which center “imperfection” with cogent philosophical insights drawing on feminist disability studies and standpoint epistemology. Purcell roots her analysis in a solidarity view that reimagines Iris Marion Young’s five faces of oppression as faces of vulnerability. Engineering Perfection showcases an important critique of transhumanism and its late capitalist ideology of genetic enhancement." -- Mechthild Nagel, SUNY Cortland"A lucid and enlightening exploration of the value of our inescapable vulnerabilities, of the ways in which social-economic processes push us toward the pathological perfectionism of genetic engineering, and of how a saner society can be created through social solidarity by means of respect for bodily difference, relational authenticity, empowered self-direction, and mutual recognition. A must read!" -- Michael K. Green, SUNY-Oneonta"Elyse Purcell’s Engineering Perfection: Solidarity, Disability, and Well-Being is a fearless, clear, and exemplary work of moral philosophy. Drawing on what Purcell calls 'the Solidarity view,' the book effortlessly weaves personal narrative, reflection on the experiences of infertility, adoption, and disability with a careful consideration of the literature covering genetic technology, disability studies, Marxism, ethics, and virtue theory. The book is a careful explication of life’s vulnerabilities—illness, aging, death, misfortune, and suffering—and the way capitalism exploits those vulnerabilities. Hopefully, Purcell suggests that a model for social transformation will depend on the virtues of respect for bodily diversity, relational authenticity, empowered self-direction, and mutual recognition. This important and expansive book will be of benefit to teachers and students across many disciplines and the general reader who desires to work toward the well-being of all in society." -- Andrew Fitz-Gibbon, SUNY CortlandTable of ContentsAcknowledgmentsIntroduction: Genetic Technologies and My Existential JourneyChapter 1: Solidarity and the Five Faces of VulnerabilityChapter 2: Facing Aging and Illness: Oppression and the Exploitable BodyChapter 3: Facing Death: Invulnerability and the “Cure”Chapter 4: Facing Misfortune: Perfection, Designer Babies, and Imaginary AppetitesChapter 5: Facing Suffering: Capitalism, QALY, and Well-beingBibliography

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Book SynopsisWhat do we owe our future children? How do advances in biomedical science bear on these obligations? How do capitalist incentives distort their execution? Advances in biotechnologies for human enhancement and designer babies appear to offer us new hope to control the fragility of human living. Some philosophers have argued that we have a moral imperative to use them, especially to eliminate disabilities. Elyse Purcell offers an opposing view, one guided by existential insights and Marxist reflections. Engineering Perfection: Solidarity, Disability, and Well-being explores the effect global capitalism may have on the selection of traits for our future children and how the commercialization of these technologies may lead to the elimination of bodily diversity. Although philosophers have addressed the possible widening between the haves and have-nots, this book considers the role oppression and exploitation may play in enhancing bodies for profit. As a challenge to the global economy of debility, Purcell proposes the Solidarity view, which embraces human vulnerability and embodied difference. By reflecting on facets of the human condition, the Solidarity view challenges us to reject our conception of the good life as human perfection, and instead reconceive of the good as one’s self-realization through the interdependent mutual recognition and co-belonging with others.Trade ReviewAdvances in medical technologies appear to offer new opportunities for improving the human condition—especially for future generations. Purcell explains how the notion that such technologies are tools that can protect humans from vulnerability is not only mistaken but also harmful. Framing her discussion within the context of her experience with fertility treatments and the process of adoption, Purcell provides an insightful critique of the commercialized and economic distortions affecting notions of the quality of life and what people owe one another and their children…. Purcell’s style is clear and engaging, and her argument is not only cogent and persuasive but also an important call for reflection as current scientific developments threaten to outpace the human capacity for moral understanding. Highly recommended. Lower- and upper-division undergraduates. Graduate students, faculty, and professionals. * Choice Reviews *In her monograph, Engineering Perfection, Elyse Purcell weaves compelling stories that center 'imperfection' with cogent philosophical insights drawing on feminist disability studies and standpoint epistemology. Purcell roots her analysis in a solidarity view that reimagines Iris Marion Young’s five faces of oppression as faces of vulnerability. Engineering Perfection showcases an important critique of transhumanism and its late capitalist ideology of genetic enhancement. -- Mechthild Nagel, SUNY CortlandA lucid and enlightening exploration of the value of our inescapable vulnerabilities, of the ways in which social-economic processes push us toward the pathological perfectionism of genetic engineering, and of how a saner society can be created through social solidarity by means of respect for bodily difference, relational authenticity, empowered self-direction, and mutual recognition. A must-read! -- Michael K. Green, SUNY-OneontaElyse Purcell’s Engineering Perfection is a fearless, clear, and exemplary work of moral philosophy. Drawing on what Purcell calls 'the Solidarity view,' the book effortlessly weaves personal narrative and reflection on the experiences of infertility, adoption, and disability with a careful consideration of the literature covering genetic technology, disability studies, Marxism, ethics, and virtue theory. The book is a careful explication of life’s vulnerabilities—illness, aging, death, misfortune, and suffering—and the way capitalism exploits those vulnerabilities. Hopefully, Purcell suggests that a model for social transformation will depend on the virtues of respect for bodily diversity, relational authenticity, empowered self-direction, and mutual recognition. This important and expansive book will be of benefit to teachers and students across many disciplines and to the general reader who desires to work toward the well-being of all in society." -- Andrew Fitz-Gibbon, SUNY CortlandElyse Purcell’s Engineering Perfection takes readers on a riveting journey that explores the promise and perils of biotechnology applications. While genetic engineering tools do many things, recent innovations brought designer babies from thought-experiment to reality. This book is a must-read for those grappling with how best to apply these technologies to future generations—our children. -- Samantha Noll, Washington State UniversityTable of ContentsAcknowledgmentsIntroduction: Genetic Technologies and My Existential JourneyChapter 1: Solidarity and the Five Faces of VulnerabilityChapter 2: Facing Aging and Illness: Oppression and the Exploitable BodyChapter 3: Facing Death: Invulnerability and the “Cure”Chapter 4: Facing Misfortune: Perfection, Designer Babies, and Imaginary AppetitesChapter 5: Facing Suffering: Capitalism, QALY, and Well-beingBibliography

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Book SynopsisEdited and authored by well-known international contributors, this book focuses on the impact that aspects of bioproduction, biochemistry and food processing can have on properties of functional foods.

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Book SynopsisThe extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.Table of ContentsMatrix biology: Extracellular matrix - Building function through complexity; Matrix biology: Gradients and patterns within the extracellular matrix; Matrix biology: ECM turnover and temporal fluctuation; Matrix biology: Structure assembly of maminin-rich matrices; Biomaterials: Incorporating ECM-derived molecular features in biomaterials; Biomaterials: Modulating and tuning synthetic extracellular matrix mechanics; Biomaterials: Protein interactions with glycosaminoglycan-based biomaterials for tissue engineering; Biomaterials: Spatial patterning of biomolecule presentation using biomaterial culture methods; Biomaterials: Controlling properties over time to mimic the dynamic extracellular matrix; Biomaterials: Supramolecular artificial extracellular matrices;

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Book Synopsis Following the routinization of assisted reproduction in the industrialized world, technologies such as in vitro fertilization, preimplantation genetic diagnosis, and DNA-based paternity testing have traveled globally and are now being offered to couples in numerous non-Western countries. This volume explores the application and impact of these advanced reproductive and genetic technologies in societies across the globe. By highlighting both the cross-cultural similarities and diverse meanings that technologies may assume as they enter multiple contexts, the book aims to foster understanding of both the technologies and the settings. Enhanced by cross-cultural perspectives, the book addresses the challenges that globalization presents to local understandings of science, technology, and medicine.Trade Review “Overall, this book provides good and interesting reading for all who want details of the cultural significances, religious and political impacts of ARTs as experienced by people of different ethnicity and religious background. Most importantly, this volume conveys the complexities of introducing and implementing ARTs in different cultures and political settings. It also brings to forth the meaning of reproduction in societies, the price and value of human life.” · Anthropological NotebooksTable of Contents Acknowledgements Introduction: Assisting reproduction, testing genes: Global encounters with new biotechnologies Daphna Birenbaum-Carmeli, Marcia C. Inhorn PART I: FAMILIES AND BEYOND: REPRODUCTIVE TECHNOLOGIES AND NEW SOCIAL ORDERS Chapter 1. East in west? Turkish migrants and the conception of the ethnic other in Germany Lisa Vanderlinden Chapter 2. Cultural meanings of assisted reproductive technologies: Women’s voices from Bulgaria Yulia Panayotova and Irina L. G. Todorova Chapter 3. ICSI: Reflections on male infertility and manhood in the Middle Eastern Muslim world Marcia C. Inhorn PART II: COUPLES AND OTHERS: ASSISTING REPRODUCTION WITH THIRD PARTIES Chapter 4. The traffic between women: Female alliance and familial egg donation in Ecuador Elizabeth Roberts Chapter 5. Law, ethics, and donor technologies in Shi’a Iran Soraya Tremayne Chapter 6. Inappropriate relations: The ban on surrogacy with In Vitro fertilization and the limits of state renovation in contemporary Vietnam Melissa J. Pashigian Chapter 7. Contested surrogacy and the gender order: An Israeli case study Daphna Birenbaum-Carmeli PART III: TESTING GENES AND USING CELLS: ENCOUNTERS WITH ADVANCED GENETIC TECHNOLOGIES Chapter 8. The genesis of embryos and ethics In Vitro: Practicing preimplantation genetic diagnosis in Argentina Kelly Raspberry Chapter 9. Assisted life: The neoliberal moral economy of embryonic stem cells in India Aditya Bharadwaj Chapter 10. Doubt is the mother of all invention: DNA and paternity in a Brazilian setting Claudia Fonseca Notes on contributors Bibliography Index

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Book SynopsisNaturally occurring compounds, or natural products, have been and continue to be an important source of commercially successful products and leads in the pharmaceutical, agrochemical and nutritional sectors. The conference Functional Molecules from Natural Sources, which was held at Magdalen College, Oxford in July 2009, set out to highlight current trends, challenges and successes in the exploitation of natural products from microbial, plant and marine sources. This book is based on the proceedings of the conference and comprises modern and emerging perspectives on natural product utilization and improved strategies for their exploitation. Several case studies on important natural product leads, or functional molecules, are presented with the strategy for their development. These detail new medical applications in the use of familiar natural molecules and advances in the understanding and manipulation of natural product biosynthesis at the genetic level. Highlights include an authoritative review of the entire field of natural anticancer agents emphasising those currently in clinical development, an account of the optimisation of the pleuromutilin antibiotic template for human use and a comprehensive description of the research programme that resulted in the discovery of platensimycin. Articles on biosynthesis include studies of the antibiotics of Streptomyces coelicolor A3(2), the anthrax siderophore petrobactin and the modification of oxidation and glycosylation events in the biosynthesis of mithramycins. Written by leading industrial and academic practitioners from each sector, the book offers authoritative updates on new approaches to the use of naturally occurring compounds within the pharmaceutical, nutraceutical and agrochemical industries.Trade ReviewThis book is based upon the proceedings of a conference, Functional Molecules from Natural Sources, organised by the Royal Society of Chemistry’s Biotechnology Group and held at Magdalen College, Oxford, in July 2009. Most of the eighteen chapters are in the form of a transcript of an individual lecture given at the conference, while others are derived from a selection of the posters presented at it, and the final chapter provides a summary of those lectures for which a transcript was not available. In order to gain most benefit from the book, readers require some prior knowledge of medicinal or pharmaceutical chemistry and, consequently, its usefulness to many chemistry undergraduate students is likely to be limited. Moreover, at £109.99, it is priced well beyond that which most undergraduates would be willing to spend. As is to be expected from any book where individual chapters are written by different authors, the style of the writing varies considerably from chapter to chapter. In some of the best chapters the original `transcript’ appears to have been re-written by its author to make it a more readable chapter in the book. The book concentrates on the continuing importance of active compounds originally identified in and isolated from microbial, plant, and marine sources. The first chapter consists of a comprehensive survey of anticancer compounds that are currently undergoing clinical trials. This is followed by chapters that are case studies of the identification of functional compounds, their subsequent development and enhancement. While later chapters deal with the biosynthesis and genetics of active compounds. Altogether there is much to interest those working in drug discovery and development, or related fields. For undergraduate students, and their teachers, probably the two most useful chapters are “Discovery and Development of Antibiotics with Novel Modes of Action” (S B Singh), an interesting and elegantly written account of the discovery of platensimycin for development as a new antibiotic, and “High Capacity Countercurrent Chromatography for Fast Isolation of Natural Products” (I J Gerrard and D Fisher), a concise account of an important technique that is unlikely to be encountered in standard undergraduate chemistry textbooks. The book contains few errors, and these are simply printing mistakes. However, in some of the cases where the skeletal formula of a compound is included in the text it is on a different page to that in which the compound is first introduced, thus necessitating superfluous page turning and sometimes making it more difficult to compare molecular structures, while in others the size in which the formula has been printed is so small (e.g. page 63, figure 11) as to make comparison of structures hard work. Other figures too, including some photographs of cultures from a microbial strain collection (page 85, figure 2) have been printed too small to serve any useful purpose. The use of colour in the three dimensional molecular diagrams, especially where this had clearly been intended (e.g. page 179, figure 22), would also have been helpful. Although such flaws are not uncommon in contemporary chemistry texts, it would have made the reading of this book a more comfortable experience if they had been rectified prior to publication. It is possible that increasing the number of pages to accommodate larger figures or enable their position in the text to be changed, and the use of colour for diagrams, were rejected on grounds of cost. But if that is the case, a more appropriate economy would have been to publish the book as a paperback rather than a hardback. -- Julian Perfect - New York University in London * Higher Phys Ed Sci Acad Cen - Journal 22 Vol 12 Issue 1 *Table of ContentsAntitumour Agents from Nature; From Natural Products to Medicinal Chemistry; New Approaches for Drug Discovery with Natural Products; Biosynthesis and Biosynthetic Engineering of Nonribosomal Lipopeptides; Why Natural Product Discovery Won't Meet the Requirements of Market-Driven Economics; Marine Natural Products; From the Seabed to the Hospital Bed; Development of Lantibiotics for Treatment of Nosocomial Infections; Imino Sugars: A Major New Group of Therapeutic Agents; Well, Naturally; Modifying Oxidation and Glycosylation Events in the Biosynthesis of Natural Product Anticancer Drugs û Challenges for Combinatorial Biosynthesis; Pleuromutilins: Antibiotic Optimisation for Human Therapeutic Use; Acetogenic Anthraquinones and Alkaloids - Online Structural Elucidation, Biosynthesis, Bioactivities and Total Synthesis; Finding New Antibacterials: Opening a Window on the Black Box of Natural Product Discovery; Potential Plant Natural Products for Management of Neglected Diseases; Chemical Diversity by Other Means: The Biosynthesis of Polyketide Drugs; Structural, Synthetic and Biosynthetic Studies on an 'Acyl Transferase-Less. Polyketide Antibiotic, Mupirocin; Switching on Defence Genes with Plant Secondary Metabolites; Natural Products as Leads for New and Innovative Crop Protection Chemicals

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Book SynopsisSynthetic Biology — A Primer gives a broad overview of the emerging field of synthetic biology and the foundational concepts on which it is built. It will be of interest to final year undergraduates, postgraduates and established researchers who are interested in learning about this exciting new field. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely ‘bottom-up’ and ‘top-down’ engineering approaches. ‘Top-down’ engineering utilises a conceptual framework of engineering and systematic design to build new biological systems by integrating robustly characterised biological parts into an existing system through the use of extensive mathematical modelling. The ‘bottom-up’ approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch. Exemplars of cutting-edge applications designed using synthetic biology principles are presented, including the production of novel biofuels from renewable feedstocks, microbial synthesis of pharmaceuticals and fine chemicals, and the design and implementation of biosensors to detect infections and environmental waste. The book also uses the Internationally Genetically Engineered Machine (iGEM) competition to illustrate the power of synthetic biology as an innovative research and training science. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences in synthetic biology research.Table of ContentsIntroduction to Molecular Biology; Introduction to Engineering Principles; Foundational Technologies for Synthetic Biology; The Synthetic Biology Community; Bottom-Up Approaches; Bio-Parts, Devices and Systems; Modelling and Systematic Design in Synthetic Biology; Applications for Synthetic Biology.

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Book SynopsisSynthetic Biology — A Primer gives a broad overview of the emerging field of synthetic biology and the foundational concepts on which it is built. It will be of interest to final year undergraduates, postgraduates and established researchers who are interested in learning about this exciting new field. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely ‘bottom-up’ and ‘top-down’ engineering approaches. ‘Top-down’ engineering utilises a conceptual framework of engineering and systematic design to build new biological systems by integrating robustly characterised biological parts into an existing system through the use of extensive mathematical modelling. The ‘bottom-up’ approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch. Exemplars of cutting-edge applications designed using synthetic biology principles are presented, including the production of novel biofuels from renewable feedstocks, microbial synthesis of pharmaceuticals and fine chemicals, and the design and implementation of biosensors to detect infections and environmental waste. The book also uses the Internationally Genetically Engineered Machine (iGEM) competition to illustrate the power of synthetic biology as an innovative research and training science. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences in synthetic biology research.Table of ContentsIntroduction to Molecular Biology; Introduction to Engineering Principles; Foundational Technologies for Synthetic Biology; The Synthetic Biology Community; Bottom-Up Approaches; Bio-Parts, Devices and Systems; Modelling and Systematic Design in Synthetic Biology; Applications for Synthetic Biology.

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Book SynopsisThis expanded and updated edition of the 2007 version introduces readers from various backgrounds to the rapidly growing interface between biology and nanotechnology. It intellectually integrates concepts, applications, and outlooks from these major scientific fields and presents them to readers from diverse backgrounds in a comprehensive and didactic manner.Written by two leading nanobiologists actively involved at the forefront of the field both as researchers and educators, this book takes the reader from the fundamentals of nanobiology to the most advanced applications.The book fulfils a unique niche: to address not only students, but also scientists who are eager (and nowadays obliged) to learn about other state-of-the-art disciplines. The book is written in such a way as to be accessible to biologists, chemists, and physicists with no background in nanotechnology (for example biologists who are interested in inorganic nanostructures or physicists who would like to learn about biological assemblies and applications thereof). It is reader-friendly and will appeal to a wide audience not only in academia but also in the industry and anyone interested in learning more about nanobiotechnology.Table of ContentsIntroduction: Nanobiotechnology and Bionanotechnology; A Brief Introduction to Nanotechnology; Natural Biological Assembly at the Nano-Scale; Nanometric Biological Assemblies: Molecular and Chemical Basis for Interaction; Molecular Recognition and the Formation of Biological Structures; Self-Assembly of Biological and Bio-Inspired Nano-Materials; Application of Biological Assemblies in Nanotechnology; Medical and Other Applications of Bionanotechnology; Future Prospects for Nanobiotechnology and Bionanotechnology; Concluding Remarks: The Prospects and Dangers of the Nanobiological Revolution; Appendix A: There's Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics (by Richard P Feynman); Appendix B: List of Bionanotechnological and Nanobiotechnological Companies; Appendix C: Glossary.

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Book SynopsisThe book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.

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Book SynopsisThe book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.

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Book SynopsisThis is the second edition of the classic book An Introduction to Bioceramics which provides a comprehensive overview of all types of ceramic and glass materials that are used in medicine and dentistry. The enormous growth of the field of bioceramics is due to the recognition by the medical and dental community of the importance of bioactive materials to stimulate repair and regeneration of tissues. This edition includes 21 new chapters that document the science and especially the clinical applications of the new generation of bioceramics in the field of tissue regeneration and repair. Important socioeconomic factors influencing the economics and availability of new medical treatments are covered with updates on regulatory procedures for new biomaterials, methods for technology transfer and ethical issues.The book contains 42 chapters that offer the only comprehensive treatment of the science, technology and clinical applications of all types of bioceramic materials used in medicine and dentistry. Each chapter is written by leaders in their specialized fields and is a thorough review of the subject matter, unlike many conference proceedings. All chapters have been edited to reflect the same writing style, making the book an easy read. The completeness of treatment of all types of bioceramics and their clinical applications makes the book unique in the field and invaluable to all readers.Table of ContentsUse of Alumina and Zirconia in Surgical Implants (S. F. Hulbert); Bioactive Glasses: Angiogenesis (A. Boccacini and A. A. Gorustovich); Clinical Applications of Bioactive Glasses: Ridge Maintenance (L. L. Hench); Clinical Applications of Bioactive Glasses: Maxillofacial Repair (I. Thompson); A/W Glass-Ceramic: Processing and Properties (T. Kokubo); Machinable and Phosphate Glass-Ceramics (W. Hohland and V. Vogel); Si-Substituted Hydroxyapatite (S. Best); Hydroxylapatite Coatings (W. R. Lacefield); Pyrolytic Carbon Prostheses: Clinical Results (J. Schute and L. L. Hench); Radiotherapy Glasses (D. Day and T. Day); Porous Hollow Glass Microspheres (G. Wicks); Regulation of Medical Devices: Current Status (D. Greenspan); and other papers.

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Book SynopsisThis book explores the significance of soil microbial diversity to understand its utility in soil functions, ecosystem services, environmental sustainability, and achieving the sustainable development goals. With a focus on agriculture and environment, the book highlights the importance of the microbial world by providing state-of-the-art technologies for examining the structural and functional attributes of soil microbial diversity for applications in healthcare, industrial biotechnology, and bioremediation studies. In seven chapters, the book will act as a primer for students, environmental biotechnologists, microbial ecologists, plant scientists, and agricultural microbiologists. Chapter 1 introduces readers to the soil microbiome, and chapter 2 discusses the below ground microbial world. Chapter 3 addresses various methods for exploring microbial diversity, chapter 4 discusses the genomics methods, chapter 5 provides the metaproteomics and metatranscriptomics approaches and chapter 6 details the bioinformatics tools for soil microbial community analysis, and chapter 7 concludes the text with future perspectives on further soil microbial uses and applications. Table of ContentsChapter1: Introduction.- Chapter2: Belowground microbial communities: A key players for soil and environmental Sustainability.- Chapter3: Methods for exploring soil microbial diversity.- Chapter4: Genomics based methods for microbial diversity analysis from soils.-Chapter5: Metaproteomics and metatranscriptomics for microbial communities profiling.- Chapter6: Bioinformatics tools for soil microbial community analysis.- Chapter7: Conclusion and future perspectives

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Book SynopsisChapter 1. Meet your Biosignals.- Chapter 2. Biosignals Sensor Creation.- Chapter 3. Arduino Essentials.- Chapter 4. Analog Signals.- Chapter 5. Data Transmission.- Chapter 6. Sampling.- Chapter 7. Live Streaming.-Chapter 8. Basic Primer on APIs.- Chapter 9. Real-time Analytics.- Chapter 10. Essentials of Data Processing.- Chapter 11. Working with Features.- Chapter 12. Frequency Domain.- Chapter 13. Signal Modulation.- Chapter 14. Machine Learning.- Chapter 15. Machine Learning Strikes Back.- Chapter 16. File Exploration.- Chapter 17. From Python to the World.- Chapter 18. Interchanging Data.- Chapter 19. Into the World Wild Web.- Chapter 20. Jazzing Up Your UIs.-Chapter 21. Tame Your Pages.

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Book SynopsisPotenzial modellbasierter Versuchsplanungsansätze für das Scale-down von Bioprozessen.- Digitale Zwillinge und ihre Rolle in der modellgestützten Versuchsplanung.- Digitale Zwillinge für die Entwicklung und Umsetzung von Bioprozesssteuerungsstrategien.- Der Kalman-Filter zur Überwachung von Kultivierungsprozessen.- Die Herausforderung der Implementierung digitaler Zwillinge in operativen Wertschöpfungsketten.- Digitale Zwillinge in der (Bio-)Pharmaindustrie.- Numerische Methoden für das Design und die Beschreibung von In-vitro-Expansionsprozessen menschlicher mesenchymaler Stammzellen.- Euler-Lagrange-Simulationen: Ein geeignetes Werkzeug zur Vorhersage der Zellleistung in industriellen Bioreaktoren.

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Book Synopsis"... Mit den beiden Buchteilen ... liegt ein geeignetes Lehrbuch vor. Mehrere durchgerechnete Beispiele zu jedem Abschnitt ergänzen die praktische Handhabung. Die zahlreichen Bilder sind anschaulich gestaltet..." (Chemische Technik)Trade Review"... Mit den beiden Buchteilen Mechanische Verfahrenstechnik liegt ein geeignetes Lehrbuch vor. Mehrere durchgerechnete Beispiele zu jedem Abschnitt ergänzen die praktische Handhabung. Die zahlreichen Bilder sind anschaulich gestaltet. Die Bücher können Studierenden empfohlen werden." (Chemische Technik)Table of Contents7 Partikelabscheidung aus Gasen.- 8 Fest-Flüssig-Trennen.- 9 Agglomerieren.- 10 Zerkleinern.- 11 Wirbelschichten und pneumatische Färderung.- Stichwortverzeichnis.

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Book SynopsisDuring the last two decades, stem cells have progressed from merely a concept to a vibrant field of regenerative medicine which is aimed at addressing the root cause of the problem rather than conventional methods of intervention that mostly provide symptomatic relief.Stem cell therapy either alone or in combination with the other established treatment strategies is a hope for patients who suffer from the 'incurable' diseases such as Alzheimer, diabetes, myocardial infarction etc. Besides aspirations in the clinical perspective, stem cells provide excellent in vitro disease models for drug development.Given the significance of the field, the proposed book will be a compilation of the bench experience of experts from various research labs involved in the cutting edge area of stem cell research.

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Book SynopsisIn this book, Dr Quintyn considers whether genetic engineering will exacerbate social injustices and/or lead to public safety issues. As designer babies mature, will they feel a sense of superiority or pass on mutations that negatively affect future generations? Should we ignore the risk of zoonotic (animal) diseases because they offer potential benefits for reducing organ shortages? Scientific advancement, if not guided responsibly and with public input, can be detrimental to public safety.This book is unique as it encompasses many biotechnologies within the definition of biotechnology. It gives a balanced view of biotechnology: its promise as evidenced in repairing mutations (i.e., genetic editing) and its dangers evidenced in creating (unintentionally) dangerous microbes or unregulated germline editing and cloning. Additionally, this book includes animals in biotechnological research because the success, advances, techniques, and science of genetic engineering could not have occurred without using animals (and microorganisms, insects, plants) as model organisms. A comprehensive description of the CRISPR system in bacteria and the exploitation of this knowledge in creating the CRISPR/Cas9 technology is also incorporated in this read.The author's overall goal is to discuss other biotechnology that is being used to improve and put at risk the health, environment, and safety of humans, giving the book a competitive edge. Furthermore, the book provides a provocative side in challenging scientists to consider the current belief governing research and development, which is that scientific advancement and public safety create a false dichotomy.

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Book SynopsisFor centuries, Chinese medicinal materials have been used for therapeutic purposes. Chinese medicinal materials are traditionally identified by their organoleptic characteristics, such as the texture or the odor. With the advancement of DNA technology, a molecular approach has become an important tool to complement organoleptic, morphological, anatomical and chemical techniques for the authentication and quality assurance of Chinese medicinal materials.In 2002, the authors published Authentication of Chinese Medicinal Materials by DNA Technology which is the first international reference in this field. After 20 years, this new edition updates the various useful techniques and describes the new techniques developed for molecular authentication. The procedures of each DNA technique are provided in detail for 'step-by-step' experiments.This book is divided into 5 parts with 18 chapters. Part I reviews the current status of molecular authentication and introduces a wide range of DNA techniques. Part II lists the experimental procedures for molecular authentication. Part III describes the DNA fingerprinting-based techniques. Part IV describes the DNA sequencing-based techniques. Finally, Part V provides an account on the recent advancement in molecular authentication, including guidelines for setting up a proper DNA laboratory and concluding remarks.

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Book SynopsisThis bestselling textbook will introduce undergraduate bioengineering students to the fundamental concepts and techniques, with the basic theme of integrative bioengineering. It covers bioengineering of several body systems, organs, tissues, and cells, integrating physiology at these levels with engineering concepts and approaches; novel developments in tissue engineering, regenerative medicine, nanoscience and nanotechnology; state-of-the-art knowledge in systems biology and bioinformatics; and socio-economic aspects of bioengineering.One of the distinctive features of the book is that it is integrative in nature (integration of biology, medicine and engineering, across different levels of the biological hierarchy, and basic knowledge with applications). It is unique in that it covers fundamental aspects of bioengineering, cutting-edge frontiers, and practical applications, as well as perspectives of bioengineering development. Furthermore, it covers important socio-economical aspects of bioengineering such as ethics and entrepreneurism.Table of ContentsPerspectives of Biomechanics (Y-C Fung & W Huang); Cardiac Electromechanics in the Healthy Heart (R Kerckhoffs & A McCulloch); Cardiac Biomechanics and Disease (J H Omens); Bioengineering Solution for the Treatment of Heart Failure (J T Watson); Molecular Basis of Modulation of Vascular Functions by Mechanical Forces (S Chien); Autoregulation of Blood Flow: Examining the Process of Scientific Discovery (P C Johnson); Molecular Basis of Cell and Membrane Mechanics (L A Sung); Cell Activation in the Circulation: The Auto-Digestion Hypothesis (G W Schmid-Schonbein); Blood Substitutes and the Design of Oxygen Non-Carrying and Carrying Fluids (M Intaglietta); Analysis of Human Pulmonary Circulation: A Bioengineering Approach (W Huang et al.); Pulmonary Gas Exchange (P D Wagner); Engineering Approaches to Understanding the Kidney (S C Thomson); Skeletal Muscle Tissue Bioengineering (R Lieber & S R Ward); Multi-Scale Biomechanics of Articular Cartilage (W Bae & R Sah); Design and Development of an in vivo Force-Sensing Knee Prosthesis (D L D'Lima & P C Y Chen); The Implantable Glucose Sensor: A Bioengineering Case Study (D A Gough); Stem Cells in Regenerative Medicine (L Goldstein); Engineering Compounds Targeted to Vascular Zip Codes (E Ruoslahti); The Structure of the Central Nervous System and Nanoengineering Approaches for Studying and Repairing It (G A Silva); Cellular Biophotonics: Laser Scissors (Ablation) (M W Berns); Electronic Microarrays for DNA to Nanofabrication Applications (M Heller); Systems Biology: A Four-Step Process (J Reed & B Palsson); Bioinformatics and Systems Biology: Obtaining the Design Principles of Living Systems (S Subramaniam); Synthetic Biology: Bioengineering at the Genomic Level (N Ostro et al.); Network Genomics (T Ideker); Genomes, Genomic Technologies and Medicine (X Huang); Ethics for Bioengineers (M Kalichman); Opportunities and Challenges in Bioengineering Entrepreneurism (J-S Lee); How to Move Medical Devices from Bench to Bedside (P Citron).

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Book SynopsisThis book provides a first hand and complete information on orchid biotechnology for orchid lovers, graduate students, researchers and industry growers. It contains comprehensive genomics and transcriptomics data, and a thorough discussion of the molecular mechanism of orchid floral morphogenesis. The contributors to the book are all orchid enthusiasts with more than 20 years' experience in the field.With more than 25,000 species, orchids are the most species-rich of all angiosperm families. They show wide diversity of epiphytic and terrestrial growth forms and have successfully colonized almost every habitat on earth. Orchids are fantastic for their spectacular flowers with highly evolved petal, labellum, and fused androecium and gynoecium, gynostemium, to attract pollinators for effective pollination. In addition, orchids have attracted the interest of many evolutionary biologists due to their highly specialized evolution and adaptation strategies.Orchid Biotechnology III covers the most update knowledge of orchid biotechnology research on Phalaenopsis, Oncidium, Cymbidium, Anoectohilus, Paphiopedilum, and Erycina pusilla. It will provide graduate students, researchers, orchid lovers and breeders with an opportunity to understand the mechanism why the orchids are so mysterious and spectacular. Hopefully, this information will be helpful for breeders to enhance orchid breeding and create even more elegant and grace flowers.Table of ContentsThe Orchid Viruses Found in the 21th Century; Virus Resistance; Screening for Virus Free Using Multiplex RT-PCR and Microchip; Pathogenic Bacteria Resistance; Orchid Transformation; Low Ambient Temperature-Responsive and Tissue-Specific Micrornas; Comparative Chloroplast Genomic Analysis and Developing DNA Markers; Development of SSR Markers in Phalaenopsis Orchids; DNA Barcodes Derived from Plastid trnL Intron in Phalaenopsis Species; Polyploidy in Orchids; Model for Perianth Formation in Orchids; Delay of Flower Senescence and Abscission by FOREVER YOUNG FLOWER Homolog from Oncidium Orchid; Virus-Induced Gene Silencing for Functional Genomics Research in Orchids; Databases for Orchid Genomic and Transcriptomic Research; C/D-Class MADS-Box Genes on Orchid Gynostemium and Ovule Development; Flower Development of Phalaenopsis Orchid Involves Functionally Divergent B-Class and SEPALLATA-Like Genes; Three R2R3-MYB Transcription Factors Regulate Distinct Floral Pigmentation Patterning in Phalaenopsis Spp.; Promoter Studies of B-Class MADS-Box Genes for Phalaenopsis and Oncidium Floral Morphogenesis; Current Status of Genomics Research in Erycina Pusilla; Elevated Temperature Induces Floral Transition via Up-Regulation of Cytosolic Ascorbate Peroxidase 1 and Subsequent Reduction of the Ascorbate Redox Ratio in Oncidium Hybrid Orchid; Warm-Night Temperature Delays Spike Emergence and Alters Dawn-Dusk Changes in Carbon Pool Metabolism in the Stem and Leaves of Phalaenopsis Aphrodite; RNA Interference-Based Gene Silencing of Phytoene Synthase Impairs Growth; Carotenoids, and Plastid Phenotype in Oncidium Hybrid Orchid; Chromosome Pairing Affinities in Interspecific Hybrids Reflect Phylogenetic Distances Among Lady's Slipper Orchids (Paphiopedilum); Temperature Acclimation Before Shipping and Light Acclimation After Shipping Improve the Performance of Phalaenopsis After Prolonged Dark Shipping; LED Lights Manipulation to Speed Up Tissue Culture Mass Propagation in Phaleanopsis Orchid, Estimating Nuclear DNA Content within 50 Species of the Genus Phalaenopsis Blume (Orchidaceae); A de Novo Floral Transcriptome Reveals;

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Book SynopsisThis book is an all-embracing review of biotechnology, biomedical engineering, bioinformatics, pharmacy and medicinal chemistry, and biopharmaceutical technology. Existing theories and the latest findings are discussed. Researchers, engineers, academics, and industry professionals will find this book an invaluable read.Table of ContentsBiotechnology; Medical Science; Biomedical Engineering;

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Book SynopsisWhat is bioengineering all about? How will it impact the future? Can it find the cure for diabetes and other chronic diseases? A long-awaited continuation of the 2004 book, Understanding the Human Machine: A Primer for Bioengineering, this volume intends to address these questions and more.Written together with 18 scientists active in the field, Max E. Valentinuzzi brings his decades of teaching bioengineering and physiology at the undergraduate and graduate levels to readers, giving a profound, and sometimes philosophical, insight into the realm of bioengineering.

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Book SynopsisThe diversity and specialization in orchid floral morphology have fascinated botanists and collectors for centuries. In the past 10 years, the orchid industry has been growing substantially worldwide. This interesting book focuses on the recent advances in orchid biotechnology research since the last 10 years in Taiwan. To advance the orchid industry, enhancement of basic research as well as advanced biotechnology will provide a good platform to improve the flower quality and breeding of new varieties. Important topics covered include the new knowledge of basic genome, through floral morphogenesis, floral ontology, embryogenesis, micropropagation, to functional genomics such as EST, virus-induced gene silencing, and genetic transformation.

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Book SynopsisIntelligent materials are emerging composite functional materials that have boomed since the 1990s. The intelligent material system, involving a multitude of structures and functions, combines studies that explore nature, mimic nature and surpass nature. It also provides novel ideas, new theories, and cutting-edge methodologies for the innovation of science and technology. Thus, mimicking the micro/nanostructures and functions found in nature will build a bridge between biology and technology, which may provide inspirations for solving today's technological problems.This book gives a complementary introduction about natural and artificial micro/nanoscale interfacial materials, devoting largely to the intelligent materials with special wettabilities. Inspired by nature, the authors proposed a concept of “binary cooperative complementary micro/nanoscale interfacial materials”. Based on this design concept, the contact and coupling of heterogeneous materials will result in novel properties on the surface or interface of materials, which may create new functional materials and devices. This book combines popular science and professional knowledge, which will be suitable for not only researchers but also science lovers.

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Book SynopsisIntelligent materials are emerging composite functional materials that have boomed since the 1990s. The intelligent material system, involving a multitude of structures and functions, combines studies that explore nature, mimic nature and surpass nature. It also provides novel ideas, new theories, and cutting-edge methodologies for the innovation of science and technology. Thus, mimicking the micro/nanostructures and functions found in nature will build a bridge between biology and technology, which may provide inspirations for solving today's technological problems.This book gives a complementary introduction about natural and artificial micro/nanoscale interfacial materials, devoting largely to the intelligent materials with special wettabilities. Inspired by nature, the authors proposed a concept of “binary cooperative complementary micro/nanoscale interfacial materials”. Based on this design concept, the contact and coupling of heterogeneous materials will result in novel properties on the surface or interface of materials, which may create new functional materials and devices. This book combines popular science and professional knowledge, which will be suitable for not only researchers but also science lovers.Table of ContentsSummary of Biomimetic Smart Nano-scale Interfacial Materials; Living Organisms with Special Surface Performance; Wettability of the Solid Surface; Biomimic Superhydrophobic Surface; Smart Nanoscale Interfacial Materials with Special Wettability; Conclusion and Prospect.

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Book SynopsisThis book is a tribute to Professor Yuan-Cheng Fung, the Father of Biomechanics and a pioneer in Bioengineering, in honor of his 90th Birthday. The book consists of articles contributed by his colleagues, students, friends and family. These articles illustrate Professor Fung's profound influence on outstanding leaders in bioengineering, especially biomechanics, and on the life and work of all people who have been in contact with him. The scientific topics covered range from fundamentals of science and engineering (e.g., residual stress, flow dynamics, and cellular signaling) to clinical disorders (e.g., atherosclerosis, diabetes, and hypertension). The articles cover the whole spectrum of biological hierarchy, from genes/molecules to cells/tissues, and organs/systems, with close correlations between engineering and biomedical sciences. This book provides an excellent view of the marvelous contributions of Professor Fung as a Renaissance Man.Table of ContentsMechanisms Underlying Soft Tissues Non-Linear Elasticity, Quasi-Linear Viscoelasticity, Preconditioning, and Residual Stress (Y Lanir); Biomechanics of an Isolated Single Stress Fiber (M Sato & S Deguchi); The Origin of Pre-Stress in Biological Tissues - A Mechano-Electrochemical Model: A Tribute to Prof. Y-C Fung (L Q Wan et al.); How Blood Flow Shapes Neointima (S Q Liu); The Role of Biomechanics in Understanding Adaptive Remodeling in the Microcirculation (T Skalak); Computational Simulations of the Buckling of Oval and Tapered Arteries (A Northcutt et al.); Role of the Structural and Signaling Molecules in Cardiac Mechanotransduction (A Raskin et al.); A Novel Hemodynamic Analysis of Echocardiograms (T-K Hung); In Vitro Biomechanical Studies in Aging Human Lungs (S Majd & M Yen); Modeling the Oxygen Uptake in Pulmonary Capillaries (C-J Chuong); Two Very Different Pulmonary Circulations: Mammal and Bird (J West); Fluid Flow Induced Calcium Response in Bone Cell Network (B Huo et al.); Analysis of the Models for Cytoskeletal Rheology (T Y Kim et al.); Y-C Fung and the Biomechanics of Hearing (R Gan); A Model for a Class of Diffusion-Based Intercellular Communication (S Nemat-Nasser & A Amirkhizi); Stem Cells. Biomechanics and Dr. Fung (T Ashan et al.); Biomechanics Insights Into the Pathophysiology of Human Diseases (C T Lim); Of Mice and Men ... and a China Connection (Atherosclerosis) (D Giddens et al.); Multi-Patient Fluid-Structure Interaction Studies for Carotid Atherosclerotic Plaque Progression Based on Serial Magnetic Resonance Imaging (D Tang et al.); Current Status on Countermeasures for Hypertensive Symptoms and Hypotension (J-S Lee); Pressure Ulcers, Pressure and Flowmotion (Z-Y Lee et al.); Mechanisms of Pulmonary Arterial Hypertension (J Yuan); Correlation of Whole Blood Viscosity with Real-Time Microvascular Abnormalities in Type-1 Diabetes Mellitus Patients (A Cheung); Y-C Fung and Biomechanics: From Organs-Systems to Molecules-Genes (S Chien); Dr. Fung - My Respected Mentor and Cherished Friend (S Woo); A Tribute to Yuan-Cheng Fung on His 90th Birthday (G Schmid-Schoenbein); and other Tribute articles.

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Book SynopsisThis compendium gives a comprehensive overview of the advances in fibrillation-defibrillation knowledge — recognition of fibrillation as a unique life threatening cardiac arrhythmia; discovery of the electric discharge in its double role of culprit and savior; and technological improved contributions.The book stands on the well-known philosophy of Education-Based on Problems (or EBP), that is, take fibrillation as a medical daily problem and search for that knowledge, technique or principle trying to solve it.The book is interdisciplinary, multidisciplinary and transdisciplinary. It addresses undergraduate and graduate biomedical engineering students, physicians going into cardiology, clinical engineers and clinical engineering technicians, nurses, paramedics and emergency medical personnel.Table of ContentsFibrillation:Definition;Mechanisms;Causes;Types;Clinical and Surgical Significance;Fibrillation Variables and Thresholds;; Defibrillation:Definition and Early Developments;Chemical and Electrical Defibrillation;Variables;Thresholds and Concept of Dose;Cardiopulmonary Resuscitation;Cardioversion;Ablation;; Defibrillators:Types;External;Internal;Implantable;Pacemakers;; Detection of Fibrillation:Criteria for Detection;Algorithms;Defibrillation Pain Because of Too Early Detection;Electrodes and Pastes;Electrode/Tissue Impedence;Electrode Types;Pastes;; Efficacy and Safety:Safety Levels;Isolation;Electromagnetic Interference;Standards;; Theoretical Models:Non-Linear Dynamic Systems;Hodgkin-Huxley Equations;Boenhoeffer-van der Pol Equations;Chaos Theory;Statistical Models;;

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Book SynopsisOrchid Biotechnology II presents a series of recent works on both basic and applied researches in biotechnology progress for Phalaenopsis and Oncidium orchids. These include the development of flower, ovule, gynostemium and perianth, the discovery of new orchid-infecting viruses and virus movement, secondary metabolites, technology of DNA endoduplication and genetic transformation, growth regulation by micronutrition and orchid mycorrhiza, and plant growth substances for flowering.The diversity and specialization in orchid floral morphology have fascinated botanists and collectors for centuries. The orchid industry has been growing substantially in the past ten years worldwide. This book focuses on the recent advances in the research of orchid biotechnology from the past ten years in Taiwan. To advance the orchid industry, enhancement of basic research as well as advanced biotechnology will provide a good platform to improve flower quality and breeding of new varieties.Table of ContentsMolecular Phylogeny and Biogeography of Phalaenopsis Species (C-C Tsai); Endopolyploidy in Phalaenopsis Orchid and Its Application in Polyploid Breeding (W-H Chen et al.); Growth Responses and Changes of Active Components as Influenced by Elevations and Orchid Mycorrhizae on Anoectochilus formosanus Hayata (S-F Cheng et al.); Compositional Variation in the Polysaccharides of the Pseudobulb of Oncidium 'Gower Ramsey' during Different Stages of Inflorescence Development (K-W Yeh et al.); Coloration and Color Patterning in Floral Tissues of Oncidium Gower Ramsey (C-Y Chiou et al.); Qualitative and Quantitative Analyses of Pigments in Phalaenopsis Species (P-C Kuo et al.); Biosynthetic Pathway of Pigments in Phalaenopsis Species (P-C Kuo et al.); Biosynthetic Regulation of Floral Scent in Phalaenopsis (Y-Y Hsiao et al.); Warm- and Cool-Night Temperature Alter Carbon Dioxide Fixation Pattern and Biochemical Metabolism in Phalaenopsis Aphrodite (Y-C Tseng et al.); and other papers.

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