Biotechnology Books
Springer Physics and Chemistry Basis of Biotechnology Focus on Biotechnology 7
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£123.49
Taylor & Francis Inc Digital Microfluidic Biochips Synthesis Testing
Book SynopsisDigital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips.The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increaTable of ContentsSynthesis Techniques. Testing Techniques. Reconfiguration-Based Defect Tolerance.
£999.99
Springer Chemical Process Computations
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£237.49
Pharmagellan, LLC Analyzing Biotec Clinical Trials
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£13.63
LEGARE STREET PR What is Darwinism
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£22.75
LEGARE STREET PR What is Darwinism
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£14.96
LEGARE STREET PR Immunity in Infective Diseases
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£32.25
LEGARE STREET PR Immunity in Infective Diseases
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LEGARE STREET PR A Critique of the Theory of Evolution
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LEGARE STREET PR A Critique of the Theory of Evolution
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LEGARE STREET PR Naturally Occurring Animal Models Of Human Disease
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Legare Street Press The Social Construction of Technological Reality
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£21.80
Creative Media Partners, LLC The Potential Of An Artificial Pancreas
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Creative Media Partners, LLC Annual Report
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Humana Rice
Book SynopsisHydroponic culture of rice seedlings for stress response assay.- Total RNA extraction from rice vegetative tissues using magnetic beads.- Total RNA extraction from starchy rice endosperm.- RNA extraction from rice immature embryo using laser capture microdissection.- Using immunoblotting for detecting of a circadian clock component, Os-GI, in rice leaves.- Preparation and Sectioning of Paraffin-Embedded Tissue for Histology and Histochemistry.- Spatial Analysis of Gene Expression by In Situ Hybridization.- Purification of Anti-OSH1 IgG and Immunohistochemical Staining of Rice Shoot Apical Meristem.- Agrobacterium-mediated transformation and targeted mutagenesis using SpCas12f in rice.- Gene targeting via CRISPR/Cas9-mediated DNA double-strand break induction in rice.- Precise base substitution using CRISPR/Cas-mediated base editor in rice.- DeLTa-seq: High-throughput targeted RNA-seq of rice leaves without RNA purification.
£170.99
Humana CancerTargeted Drug Delivery
Book SynopsisApplication of Graphene Oxide in Tumor Targeting and Tumor Therapy.- Antitumoral Effect on Liver Cancer of a Tumor Penetrating and Interfering Peptide.- Computer-Aided Design for Cancer-Targeted Peptide Drugs.- Advances in the Manufacturing of CAR-NK Cells for Cancer Immunotherapy.- Addressing the Blood-Brain Barrier: Overcoming Glioblastoma Drug Delivery.- Advances in Cancer Gene Therapy: Strategies, Delivery Methods, and Challenges.- Targeted Tumor Delivery Using Extracellular Vesicles.- Peptide-Assisted CRISPR/Cas9 Delivery to Tumors.- Identification of Organ- and Disease-Specific Homing Peptides Using In Vivo Peptide Phage Display.- Cancer Vaccines.
£189.99
Humana Skin Tissue Engineering
Book Synopsis Promotion of Human Epidermal Keratinocyte Expansion in Feeder Cell Co-culture.- Isolation and Culture of Epidermal Melanocytes.- Initiating Separate Cultures of Keratinocytes and Melanocytes from a Single Biopsy.- Long-term Expansion of Mouse Primary Epidermal Keratinocytes Using a TGF-beta Signaling Inhibitor.- Isolation and Culture of Hair Follicle Dermal Sheath Mesenchymal Stromal Cells.- Isolation and Culture of Human Dermal Fibroblasts.- Isolation and Culture of Human Dermal Microvascular Endothelial Cells Jennifer Bourland.- Isolation of stromal vascular fraction by fractionation of adipose tissue.- Engineering a multilayered skin equivalent: the importance of endogenous extracellular matrix and model flexibility for nuanced and accurate skin studies.- Engineering a Multilayered Skin Substitute with Keratinocytes, Fibroblasts, Adipose Derived Stem Cells and Adipocytes.- Isolation and Culture of Epidermolysis Bullosa Cells and Organotypic Skin Models.- Engineering a pigmented skin equivalent that is responsive to external stimuli.- Bioprinting a tri-layered skin analogue.- Transdifferentiation of human dermis derived fibroblasts into iNeurons and cultivation in a collagen type 1 hydroge.- Deep proteome profiling of primary skin fibroblasts.- Characterization of human skin derived cells by Raman micro-spectroscopy.- Standard Preparation Protocol of Human Skin and Skin Substitute Samples for Transmission Electron Microscopy.- Methods for assessing scaffold vascularization with human endothelial cells.- Histological and histochemical methods for the evaluation of tissue engineered skin substitutes.- Pig Model to Test Tissue engineered Skin.- Transplantation of Autologous Dermo-Epidermal Skin Substitutes in a Pig Model.- Ex vivo human skin model to study immediate and early local responses to external stimuli.- A Method to Evaluate Skin and Skin Substitute Mechanical Properties Using a Suction Device.- GMP compliant production of therapeutic components of autologous adipose tissue.- Quality controls of autologous skin products according to European GMP guidelines.- Standardized outcome measures for the clinical application of tissue engineered products.
£189.99
£11.69
Wiley-Blackwell Body Area Communications
Book SynopsisProviding an introduction to the fundamentals of body area communications, this book covers the key topics of channel modeling, modulation and demodulation, and performance evaluation A systematic introduction to body area networks (BAN), this book focuses on three major parts: channel modeling, modulation/demodulation communications performance, and electromagnetic compatibility considerations. The content is logically structured to lead readers from an introductory level through to in-depth and more advanced topics. Provides a concise introduction to this emerging topic based on classroom-tested materials Details the latest IEEE 802.15.6 standard activities Moves from very basic physics, to useful mathematic models, and then to practical considerations Covers not only EM physics and communications, but also biological applications Topics approached include: link budget, bit error rate performance, RAKE and diversityTable of ContentsPreface ix 1 Introduction to Body Area Communications 1 1.1 Definition 1 1.2 Promising Applications 2 1.2.1 Medical and Healthcare Applications 3 1.2.2 Assistance to People with Disabilities 7 1.2.3 Consumer Electronics and User Identification 7 1.3 Available Frequency Bands 8 1.3.1 UWB Band 8 1.3.2 MICS Band 10 1.3.3 ISM Band 10 1.3.4 HBC Band 11 1.4 Standardization (IEEE Std 802.15.6-2012) 11 1.4.1 Narrow Band PHY Specification 12 1.4.2 UWB PHY Specification 13 1.4.3 HBC PHY Specification 15 References 18 2 Electromagnetic Characteristics of the Human Body 21 2.1 Human Body Composition 21 2.2 Frequency-Dependent Dielectric Properties 22 2.3 Tissue Property Modeling 23 2.4 Aging Dependence of Tissue Properties 30 2.5 Penetration Depth versus Frequency 35 2.6 In-Body Absorption Characteristic 39 2.7 On-Body Propagation Mechanism 43 2.8 Diffraction Characteristic 49 References 52 3 Electromagnetic Analysis Methods 55 3.1 Finite-Difference Time-Domain Method 55 3.1.1 Formulation 55 3.1.2 Absorbing Boundary Conditions 59 3.1.3 Field Excitation 64 3.1.4 FDTD Flow Chart and Code 65 3.1.5 Frequency-Dependent FDTD Method 67 3.2 MoM-FDTD Hybrid Method 71 3.2.1 MoM Formulation 73 3.2.2 Scattered Field FDTD Formulation 75 3.2.3 Hybridization of MoM and FDTD Method 76 3.3 Finite Element Method 78 3.4 Numerical Human Body Model 83 References 87 4 Body Area Channel Modeling 89 4.1 Introduction 89 4.2 Path Loss Model 91 4.2.1 Free-Space Path Loss 91 4.2.2 On-Body UWB Path Loss 92 4.2.3 In-Body UWB Path Loss 98 4.2.4 In-Body MICS Band Path Loss 104 4.2.5 HBC Band Path Loss and Equivalent Circuit Expression 107 4.3 Multipath Channel Model 118 4.3.1 Saleh–Valenzuela Impulse Response Model 119 4.3.2 On-Body UWB Channel Model 119 4.3.3 In-Body UWB Channel Model 135 References 141 5 Modulation/Demodulation 143 5.1 Introduction 143 5.2 Modulation Schemes 144 5.2.1 ASK, FSK and PSK 144 5.2.2 IR-UWB 147 5.2.3 MB-OFDM 151 5.3 Demodulation and Error Probability 155 5.3.1 Optimum Demodulation for ASK, FSK and PSK 155 5.3.2 Noncoherent Detection for ASK, FSK and PSK 159 5.3.3 Optimum Demodulation for IR-UWB 161 5.3.4 Noncoherent Detection for IR-UWB 164 5.3.5 MB-OFDM Demodulation 167 5.4 RAKE Reception 168 5.5 Diversity Reception 174 References 179 6 Body Area Communication Performance 181 6.1 Introduction 181 6.2 On-Body UWB Communication 182 6.2.1 Bit Error Rate 182 6.2.2 Link Budget 194 6.2.3 Maximum Communication Distance 198 6.3 In-Body UWB Communication 201 6.3.1 Bit Error Rate 201 6.3.2 Link Budget 206 6.4 In-Body MICS-Band Communication 212 6.4.1 Bit Error Rate 212 6.4.2 Link Budget 213 6.5 Human Body Communication 216 6.5.1 Bit Error Rate 216 6.5.2 Link Budget 217 6.6 Dual Mode Body Area Communication 219 References 221 7 Electromagnetic Compatibility Considerations 223 7.1 Introduction 223 7.2 SAR Analysis 225 7.2.1 Safety Guidelines 225 7.2.2 Analysis and Assessment Methods 227 7.2.3 Transmitting Power versus SAR 234 7.3 Electromagnetic Interference Analysis for the Cardiac Pacemaker 245 7.3.1 Cardiac Pacemaker Model and Interference Mechanism 245 7.3.2 Electromagnetic Field Approach 249 7.3.3 Electric Circuit Approach 250 7.3.4 Transmitting Signal Strength versus Interference Voltage 255 7.3.5 Experimental Assessment System 262 References 266 8 Summary and Future Challenges 267 Index 273
£114.90
Wiley-Blackwell Protein Analysis using Mass Spectrometry
Table of ContentsList of Contributors xiii Foreword xvii Preface xix 1 Contemporary Protein Analysis by Ion Mobility Mass Spectrometry 1Johannes P.C. Vissers and James I. Langridge 1.1 Introduction 1 1.2 Traveling-Wave Ion Mobility Mass Spectrometry 1 1.3 IM–MS and LC–IM–MS Analysis of Simple and Complex Mixtures 2 1.4 Outlook 7 Acknowledgment 8 References 8 2 High-Resolution Accurate Mass Orbitrap and Its Application in Protein Therapeutics Bioanalysis 11Hongxia Wang and Patrick Bennett 2.1 Introduction 11 2.2 Triple Quadrupole Mass Spectrometer and Its Challenges 11 2.3 High-Resolution Mass Spectrometers 12 2.4 Quantitation Modes on Q Exactive Hybrid Quadrupole Orbitrap 13 2.5 Protein Quantitation Approaches Using Q Exactive Hybrid Quadrupole Orbitrap 14 2.6 Data Processing 16 2.7 Other Factors That Impact LC–MS-based Quantitation 16 2.8 Conclusion and Perspectives of LC–HRMS in Regulated Bioanalysis 18 References 18 3 Current Methods for the Characterization of Posttranslational Modifications in Therapeutic Proteins Using Orbitrap Mass Spectrometry 21Zhiqi Hao, Qiuting Hong, Fan Zhang, Shiaw-Lin Wu, and Patrick Bennett 3.1 Introduction 21 3.2 Characterization of PTMs Using Higher-Energy Collision Dissociation 23 3.3 Application of Electron Transfer Dissociation to the Characterization of Labile PTMs 26 3.4 Conclusion 31 Acknowledgment 32 References 32 4 Macro- to Micromolecular Quantitation of Proteins and Peptides by Mass Spectrometry 35Suma Ramagiri, Brigitte Simons, and Laura Baker 4.1 Introduction 35 4.2 Key Challenges of Peptide Bioanalysis 36 4.3 Key Features of LC/MS/MS-Based Peptide Quantitation 38 4.4 Advantages of the Diversity of Mass Spectrometry Systems 41 4.5 Perspectives for the Future 41 References 42 5 Peptide and Protein Bioanalysis Using Integrated Column-to-Source Technology for High-Flow Nanospray 45Shane R. Needham and Gary A. Valaskovic 5.1 Introduction – LC–MS Has Enabled the Field of Protein Biomarker Discovery 45 5.2 Integration of Miniaturized LC with Nanospray ESI-MS Is a Key for Success 46 5.3 Micro- and Nano-LC Are Well Suited for Quantitative Bioanalysis 47 5.4 Demonstrating Packed-Emitter Columns Are Suitable for Bioanalysis 49 5.5 Future Outlook 51 References 52 6 Targeting the Right Protein Isoform: Mass Spectrometry-Based Proteomic Characterization of Alternative Splice Variants 55Jiang Wu 6.1 Introduction 55 6.2 Alternative Splicing and Human Diseases 55 6.3 Identification of Splice Variant Proteins 56 6.4 Conclusion 64 References 64 7 The Application of Immunoaffinity-Based Mass Spectrometry to Characterize Protein Biomarkers and Biotherapeutics 67Bradley L. Ackermann and Michael J. Berna 7.1 Introduction 67 7.2 Overview of IA-MS Methods 69 7.3 IA-MS Applications – Biomarkers 74 7.3.1 Peptide Biomarkers 74 7.4 IA-MS Applications – Biotherapeutics 81 7.5 Future Direction 84 References 85 8 Semiquantification and Isotyping of Antidrug Antibodies by Immunocapture-LC/MS for Immunogenicity Assessment 91Jianing Zeng, Hao Jiang, and Linlin Luo 8.1 Introduction 91 8.2 Multiplexing Direct Measurement of ADAs by Immunocapture-LC/MS for Immunogenicity Screening, Titering, and Isotyping 93 8.3 Indirect Measurement of ADAs by Quantifying ADA Binding Components 95 8.4 Use of LC–MS to Assist in Method Development of Cell-Based Neutralizing Antibody Assays 96 8.5 Conclusion and Future Perspectives 97 References 97 9 Mass Spectrometry-Based Assay for High-Throughput and High-Sensitivity Biomarker Verification 99Xuejiang Guo and Keqi Tang 9.1 Background 99 9.2 Sample Processing Strategies 100 9.3 Advanced Electrospray Ionization Mass Spectrometry Instrumentation 102 9.4 Conclusion 105 References 105 10 Monitoring Quality of Critical Reagents Used in Ligand Binding Assays with Liquid Chromatography Mass Spectrometry (LC–MS) 107Brian Geist, Adrienne Clements-Egan, and Tong-Yuan Yang 10.1 Introduction 107 10.2 Case Study Examples 114 10.3 Discussion 122 Acknowledgment 126 References 126 11 Application of Liquid Chromatography-High Resolution Mass Spectrometry in the Quantification of Intact Proteins in Biological Fluids 129Stanley (Weihua) Zhang, Jonathan Crowther, and Wenying Jian 11.1 Introduction 129 11.2 Workflows for Quantification of Proteins Using Full-Scan LC-HRMS 131 11.3 Internal Standard Strategy 133 11.4 Calibration and Quality Control (QC) Sample Strategy 135 11.5 Common Issues in Quantification of Proteins Using LC-HRMS 135 11.6 Examples of LC-HRMS-Based Intact Protein Quantification 137 11.7 Conclusion and Future Perspectives 138 Acknowledgment 140 References 140 12 LC–MS/MS Bioanalytical Method Development Strategy for Therapeutic Monoclonal Antibodies in Preclinical Studies 145Hongyan Li, Timothy Heath, and Christopher A. James 12.1 Introduction: LC-MS/MS Bioanalysis of Therapeutic Monoclonal Antibodies 145 12.2 Highlights of Recent Method Development Strategies 146 12.3 Case Studies of Preclinical Applications of LC–MS/MS for Monoclonal Antibody Bioanalysis 154 12.4 Conclusion and Future Perspectives 156 References 158 13 Generic Peptide Strategies for LC–MS/MS Bioanalysis of Human Monoclonal Antibody Drugs and Drug Candidates 161Michael T. Furlong 13.1 Introduction 161 13.2 A Universal Peptide LC–MS/MS Assay for Bioanalysis of a Diversity of Human Monoclonal Antibodies and Fc Fusion Proteins in Animal Studies 161 13.3 An Improved “Dual” Universal Peptide LC–MS/MS Assay for Bioanalysis of Human mAb Drug Candidates in Animal Studies 165 13.4 Extending the Universal Peptide Assay Concept to Human mAb Bioanalysis in Human Studies 170 13.5 Internal Standard Options for Generic Peptide LC–MS/MS Assays 173 13.6 Sample Preparation Strategies for Generic Peptide LC–MS/MS Assays 175 13.7 Limitations of Generic Peptide LC–MS/MS Assays 177 13.8 Conclusion 178 Acknowledgments 178 References 178 14 Mass Spectrometry-Based Methodologies for Pharmacokinetic Characterization of Antibody Drug Conjugate Candidates During Drug Development 183Yongjun Xue, Priya Sriraman, Matthew V. Myers, Xiaomin Wang, Jian Chen, Brian Melo, Martha Vallejo, Stephen E. Maxwell, and Sekhar Surapaneni 14.1 Introduction 183 14.2 Mechanism of Action 183 14.3 Mass Spectrometry Measurement for DAR Distribution of Circulating ADCs 186 14.4 Total Antibody Quantitation by Ligand Binding or LC–MS/MS 189 14.5 Total Conjugated Drug Quantitation by Ligand Binding or LC–MS/MS 193 14.6 Catabolite Quantitation by LC–MS/MS 196 14.7 Preclinical and Clinical Pharmacokinetic Support 197 14.8 Conclusion and Future Perspectives 198 References 198 15 Sample Preparation Strategies for LC–MS Bioanalysis of Proteins 203Long Yuan and Qin C. Ji 15.1 Introduction 203 15.2 Sample Preparation Strategies to Improve Assay Sensitivity 205 15.3 Sample Preparation Strategies to Differentiate Free, Total, and ADA-Bound Proteins 213 15.4 Sample Preparation Strategies to Overcome Interference from Antidrug Antibodies or Soluble Target 214 15.5 Protein Digestion Strategies 214 15.6. Conclusion 215 Acknowledgment 216 References 216 16 Characterization of Protein Therapeutics by Mass Spectrometry 221Wei Wu, Hangtian Song, Thomas Slaney, Richard Ludwig, Li Tao, and Tapan Das 16.1 Introduction 221 16.2 Variants Associated with Cysteine/Disulfide Bonds in Protein Therapeutics 221 16.3 N–C-Terminal Variants 225 16.4 Glycation 226 16.5 Oxidation 226 16.6 Discoloration 228 16.7 Sequence Variants 230 16.8 Glycosylation 232 16.9 Conclusion 240 References 240 Index 251
£144.35
John Wiley & Sons Inc LowFrequency Electromagnetic Modeling for
Book SynopsisProvides a detailed and systematic description of the Method of Moments (Boundary Element Method) for electromagnetic modeling at low frequencies and includes hands-on, application-based MATLAB modules with user-friendly and intuitive GUI and a highly visualized interactive output. Includes a full-body computational human phantom with over 120 triangular surface meshes extracted from the Visible Human Project Female dataset of the National library of Medicine and fully compatible with MATLAB and major commercial FEM/BEM electromagnetic software simulators. This book covers the basic concepts of computational low-frequency electromagnetics in an application-based format and hones the knowledge of these concepts with hands-onMATLABmodules. The book is divided into five parts. Part 1 discusses low-frequency electromagnetics, basic theory of triangular surface mesh generation, and computational human phantoms. Part Table of ContentsPREFACE xiACKNOWLEDGMENTS xvABOUT THE COMPANION WEBSITE xviiPART I LOW-FREQUENCY ELECTROMAGNETICS.COMPUTATIONAL MESHES.COMPUTATIONAL PHANTOMS 11 Classification of Low-Frequency Electromagnetic Problems. Poisson and Laplace Equations in Integral Form 3Introduction 31.1 Classification of Low-Frequency Electromagnetic Problems 41.2 Poisson and Laplace Equations Boundary Conditions and Integral Equations 18References 302 Triangular Surface Mesh Generation and Mesh Operations 35Introduction 352.1 Triangular Mesh and its Quality 362.2 Delaunay Triangulation. 3D Volume and Surface Meshes 462.3 Mesh Operations and Transformations 562.4 Adaptive Mesh Refinement and Mesh Decimation 752.5 Summary of MATLAB® Scripts 81References 853 Triangular Surface Human Body Meshes for Computational Purposes 89Introduction 893.1 Review of Available Computational Human Body Phantoms and Datasets 923.2 Triangular Human Body Shell Meshes Included with the Text 963.3 VHP-F Whole-Body Model Included with the Text 108References 126PART II ELECTROSTATICS OF CONDUCTORS AND DIELECTRICS. DIRECT CURRENT FLOW 1314 Electrostatics of Conductors. Fundamentals of the Method of Moments. Adaptive Mesh Refinement 133Introduction 1334.1 Electrostatics of Conductors. MoM (Surface Charge Formulation) 1344.2 Gaussian Quadratures. Potential Integrals. Adaptive Mesh Refinement 1474.3 Summary of MATLAB® Modules 162References 1675 Theory and Computation of Capacitance. Conducting Objects in External Electric Field 169Introduction 1695.1 Capacitance Definitions: Self-Capacitance 1705.2 Capacitance of Two Conducting Objects 1805.3 Systems of Three Conducting Objects 1885.4 Isolated Conducting Object in an External Electric Field 1965.5 Summary of MATLAB® Modules 204References 2126 Electrostatics of Dielectrics and Conductors 215Introduction 2156.1 Dielectric Object in an External Electric Field 2166.2 Combined Metal–Dielectric Structures 2296.3 Application Example: Modeling Charges in Capacitive Touchscreens 2396.4 Summary of MATLAB® Modules 245References 2537 Transmission Lines: Two-Dimensional Version of the Method of Moments 257Introduction 2577.1 Transmission Lines: Value of the Electrostatic Model—Analytical Solutions 2587.2 The 2D Version of the MoM for Transmission Lines 2737.3 Summary of MATLAB® Modules 284References 2878 Steady-State Current Flow 289Introduction 2898.1 Boundary Conditions. Integral Equation. Voltage and Current Electrodes 2908.2 Analytical Solutions for DC Flow in Volumetric Conducting Objects 3008.3 MoM Algorithm for DC Flow. Construction of Electrode Mesh 3118.4 Application Example: EIT 3208.5 Application Example: tDCS 3278.6 Summary of MATLAB® Modules 336References 341PART III LINEAR MAGNETOSTATICS 3479 Linear Magnetostatics: Surface Charge Method 349Introduction 3499.1 Integral Equation of Magnetostatics: Surface Charge Method 3509.2 Analytical versus Numerical Solutions: Modeling Magnetic Shielding 3589.3 Summary of MATLAB® Modules 367References 36910 Inductance. Coupled Inductors. Modeling of a Magnetic Yoke 371Introduction 37110.1 Inductance 37210.2 Mutual Inductance and Systems of Coupled Inductors 38510.3 Modeling of a Magnetic Yoke 40410.4 Summary of MATLAB® Modules 415References 421PART IV THEORY AND APPLICATIONS OF EDDY CURRENTS 42311 Fundamentals of Eddy Currents 425Introduction 42511.1 Three Types of Eddy Current Approximations 42611.2 Exact Solution for Eddy Currents without Surface Charges Created by Horizontal Loops of Current 44011.3 Exact Solution for a Sphere in an External AC Magnetic Field 45311.4 A Simple Approximate Solution for Eddy Currents in a Weakly Conducting Medium 46011.5 Summary of MATLAB® Modules 464References 47012 Computation of Eddy Currents via the Surface Charge Method 473Introduction 47312.1 Numerical Solution in a Weakly Conducting Medium with External Magnetic Field 47412.2 Comparison with FEM Solutions from Maxwell 3D of ANSYS: Solution Convergence 48112.3 Eddy Currents Excited by a Coil 48812.4 Summary of MATLAB® Modules 497References 504PART V NONLINEAR ELECTROSTATICS 50713 Electrostatic Model of a pn-Junction: Governing Equations and Boundary Conditions 509Introduction 50913.1 Built-in Voltage of a pn-Junction 51013.2 Complete Electrostatic Model of a pn-Junction 533References 54514 Numerical Simulation of pn-Junction and Related Problems: Gummel’s Iterative Solution 547Introduction 54714.1 Iterative Solution for Zero Bias Voltage 54814.2 Numerical Solution for the Electric Field Region 56014.3 Analytical Solution for the Diffusion Region: Shockley Equation 57914.4 Summary of MATLAB® Modules 587References 588INDEX 591
£999.99
John Wiley & Sons Inc Bioprocessing Piping and Equipment Design
Book SynopsisThe only comprehensive and authoritative reference guide to the ASME Bioprocessing Piping and Equipment (BPE) standard This is a companion guide to the ASME Bioprocessing Piping and Equipment (BPE) Standard and explains what lies behind many of the requirements and recommendations within that industry standard. Following an introductory narrative to the Standard''s early history, industry related codes and standards are explained; the design and engineering aspects cover construction materials, both metallic and nonmetallic; then components, fabrication, assembly and installation of piping systems are explored. Examination, Inspection and Testing then precede the ASME BPE certification process, concluding with a discussion on system design. The author draws on many years'' experience and insights from first-hand involvement in the field of industrial piping design, engineering, construction, and management, which includes the bioprocessing industry. The reader wTable of ContentsList of Figures xx List of Tables xxix List of Forms xxxi Series Preface xxxii Preface xxxiii Acknowledgments lxxvii About the Author lxxx 1 Introduction, Scope, and General Requirements of the BPE 1 1.1 Introduction 1 1.2 Scope of the ASME BPE Standard 2 1.3 Intent of the BPE Standard 6 1.4 ASME B31.3 Chapter X 7 1.5 Terms and Definitions 8 1.6 Quality Assurance 11 1.6.1 Documentation 13 1.7 An Essential Understanding of Codes and Standards 17 1.8 Source of BPE Content 20 1.8.1 Government Regulations 20 1.8.2 Generally Accepted Principals and Practices of the Industry 21 1.8.3 Research and Testing Done by the BPE Membership 21 1.9 ASME B31.3 Process Piping Code Chapter X 22 1.9.1 B31.3 Chapter X as Supplement to the Base Code 23 1.9.2 Harmonization of the BPE Standard and B31.3 Chapter X 24 2 Materials 25 2.1 Scope of this Chapter 25 2.2 Materials of Construction 25 2.3 Metallic Materials 26 2.3.1 Understanding ASTM Material Designations 27 2.3.2 Stainless Steel 36 2.3.3 The World of Crystallography 37 2.3.4 Pitting Resistance Equivalent Number (PREn) 42 2.3.5 Alloying Constituents in Austenitic Stainless Steel 45 2.3.6 Dual Certified Stainless Steels 46 2.3.7 So Why 316L Stainless Steel? 47 2.4 Nonmetallic Materials 49 2.4.1 What Are Nonmetallic Materials? 49 2.4.2 Extractables and Leachables 52 2.4.3 Single]Use Systems and Components 54 2.5 Surface Finish 57 2.6 Rouge 63 2.6.1 Class I Rouge 64 2.6.2 Class II Rouge 65 2.6.3 Class III Rouge 66 2.6.4 Background on Rouge 68 2.6.5 Source of Rouge 69 2.7 Electropolishing 70 2.7.1 Irregularities or Flaws in Electropolishing 74 2.8 Passivation 76 3 Process Components 81 3.1 Process Components 81 3.2 Pressure Ratings 81 3.2.1 Pressure Ratings of Welded Components 81 3.2.2 Pressure Ratings and Other Fundamentals of Hygienic Clamp Joint Unions 86 3.3 Hygienic Clamp and Automatic Tube Weld Fittings 89 3.4 Sanitary Valves 101 3.5 Seals 102 3.6 Instruments 105 3.6.1 Coriolis Flow Meter 106 3.6.2 Radar Level Instruments 106 3.6.3 Pressure Instruments 106 3.6.4 Temperature Instruments 106 3.6.5 Analytical Instruments 106 3.6.6 Optical Devices 107 4 Fabrication, Assembly, and Installation 108 4.1 Scope and Introduction to this Chapter 108 4.1.1 Scope 108 4.1.2 Introduction 108 4.2 Fabrication 111 4.2.1 Fabrication Drawings and Spool Pieces 111 4.3 Fabrication of Metallic Tubing 116 4.3.1 Welding Documentation and Retention 116 4.3.2 Welding for Piping Systems 119 4.4 Fabrication of Nonmetallic Piping and Tubing 126 4.4.1 Fabrication of Polymeric Components 126 4.5 Assembly and Installation 131 4.5.1 General 131 4.5.2 Characteristics of the Hygienic Clamp Joint 131 4.6 The Piping Installation Process 140 4.6.1 Field Assembly and Installation (Stick Built) 140 4.6.2 As]Built and Other Drawings 142 4.6.3 Skid or Module Fabrication 144 5 Examination, Inspection, and Testing 147 5.1 Examination, Inspection, and Testing 147 5.2 Examination 148 5.2.1 Weld Examination 150 5.3 Inspection 153 5.4 Leak Testing of Piping 155 6 Equipment and Component Quality 157 6.1 Assured Quality 157 6.2 BPE Certification 157 6.3 A Quality Management System 161 6.4 Purpose 164 7 Design 166 7.1 BPE Scope of Design 166 7.2 Intent of Part SD 167 7.3 It’s a Bug’s Life 168 7.3.1 Perspective on Bacteria 168 7.4 A Preamble to Design 177 7.4.1 Undeveloped Subject Matter 177 7.4.2 Containment 177 7.4.3 Working with BPE and B31.3 180 7.4.4 Fabrication 183 7.4.5 Materials of Construction 185 7.4.6 Cleanability and Drainability 186 7.4.7 Bioprocessing System Boundaries 186 7.5 Design 186 7.5.1 The System 187 8 BPE Appendices 202 8.1 Mandatory and Nonmandatory Appendices 202 8.2 Mandatory Appendices 203 8.2.1 Mandatory Appendix I: Submittal of Technical Inquiries to the BPE Committee 203 8.2.2 Mandatory Appendix II: Standard Units 204 8.3 Nonmandatory Appendices 204 8.3.1 Nonmandatory Appendix A—Commentary: Slag 204 8.3.2 Nonmandatory Appendix B: Material and Weld Examination/Inspection Documentation 204 8.3.3 Nonmandatory Appendix C: Slope Measurement 204 8.3.4 Nonmandatory Appendix D: Rouge and Stainless Steel 204 8.3.5 Nonmandatory Appendix E: Passivation Procedure Qualification 205 8.3.6 Nonmandatory Appendix F: Corrosion Testing 205 8.3.7 Nonmandatory Appendix G: Ferrite 205 8.3.8 Nonmandatory Appendix H: Electropolishing Procedure Qualification 205 8.3.9 Nonmandatory Appendix I: Vendor Documentation Requirements for New Instruments 206 8.3.10 Nonmandatory Appendix J: Standard Process Test Conditions (SPTC) for Seal Performance Evaluation 206 8.3.11 Nonmandatory Appendix K: Standard Test Methods for Polymers 206 8.3.12 Nonmandatory Appendix L: Spray Device Coverage Testing 207 8.3.13 Nonmandatory Appendix M—Commentary: 316L Weld Heat]Affected Zone Discoloration Acceptance Criteria 207 8.3.14 Nonmandatory Appendix N: Guidance When Choosing Polymeric and Nonmetallic Materials 207 8.3.15 Nonmandatory Appendix O: General Background/Useful Information for Extractables and Leachables 207 8.3.16 Nonmandatory Appendix P: Temperature Sensors and Associated Components 208 8.3.17 Nonmandatory Appendix Q: Instrument Receiving, Handling, and Storage 208 8.3.18 Nonmandatory Appendix R: Application Data Sheet 208 8.3.19 Nonmandatory Appendix S—Polymer Applications: Chromatography Columns 208 8.3.20 Nonmandatory Appendix T: Guidance for the Use of US Customary and SI Units 208 Appendices Appendix A Cleaning and Leak Testing Procedure 209 Appendix B Biotechnology Inspection Guide Reference Materials and Training Aids 251 Appendix C Guide to Inspections of High Purity Water Systems 286 Appendix D Guide to Inspections of Lyophilization of Parenterals 304 Appendix E Guide to Inspections and Validation of Cleaning Processes 322 Appendix F Guide to Inspections of Dosage Form Drug Manufacturer’s—CGMPR’s 331 Appendix G Guide to Inspections Oral Solutions and Suspensions 349 Appendix H Guide to Inspections of Sterile Drug Substance Manufacturers 356 Appendix J Guide to Inspections of Topical Drug Products 366 Appendix K BPE History—Letters and Notes 375 Appendix L Component Dimensions 420 Further Reading 440 Index 445
£999.99
Palgrave MacMillan UK Inquiring into Human Enhancement Interdisciplinary and International Perspectives Health Technology and Society
Book SynopsisHuman enhancement has become a major concern in debates about the future of contemporary societies. This interdisciplinary book is devoted to clarifying the underlying ambiguities of these debates, and to proposing novel ways of exploring what human enhancement means and understanding what practices, goals and justifications it entails.Table of ContentsIntroduction; Simone Bateman, Jean Gayon, Sylvie Allouche, Jérôme Goffette, Michela Marzano PART I: HUMAN ENHANCEMENT: WHAT DO WE MEAN? 1. The Concept and Practices of Human Enhancement: What is at Stake?; Simone Bateman and Jean Gayon 2. Enhancement: Why We Should Distinguish Anthropotechnics from Medicine; Jérôme Goffette 3. Why Do We Wish to Be Enhanced; Vincent Menuz 4. The Moral Ambiguity of Human Enhancement; Ruud ter Meulen PART II: LEARNING FROM ENHANCEMENT PRACTICES 5. A Scale and a Paradigmatic Framework for Human Enhancement; Pascal Nouvel 6. From Repair to Enhancement: The Use of Technical Aids in the Field of Disability; Myriam Winance, Anne Marcellini and Eric de Léséleuc 7. BMI (Brain-Machine Interface) as a Tool for Understanding Human-Machine Cooperation; Selim Eskiizmirliler and Jérôme Goffette 8. Doping Behavior as an Indicator of Performance Pressure; Patrick Laure and Sylvie Allouche PART III: VISIONS OF THE FUTURE: LESSONS FROM ART AND FICTION 9. The Earth as Our Footstool: Visions of Human Enhancement in 19th and 20th Century Britain; Christopher Coenen 10. Transcendental Medicine Versus the ' 'Prisonhouse of the Flesh ' ': Enhancement in R.L. Stevenson ' 's The Strange Case of Dr. Jekyll and Mr. Hyde; Françoise Dupeyron-Lafay 11. Biotechnology and the Future of Sport: A Scenario; Jean-Noël Missa 12. Adaptation and Emortality: Human Enhancement in ' 'Tales of the Biotech Revolution ' '; Brian Stableford
£44.99
Lulu.com BIOTECHNOLOGY BASICS
£28.72
Houghton Mifflin A Crack In Creation
Book SynopsisBY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the
£15.29
Bloomsbury Publishing PLC Visceral Prostheses
Book SynopsisIn the postmodern era, when the interface of bodies, biologies and technologies increasingly challenges the very notion of what counts as human, this open access book proposes new understandings of the limits and possible extensions of posthuman embodiment. Focusing on prostheses, Margrit Shildrick broadens our understanding of both what prostheses are and what they might mean for human embodiment. As well as rehabilitation devices used by disabled people to replace or augment impaired parts of the body, Shildrick introduces visceral organic prostheses, which involve any cellular material that cannot be identified with the self, from organ transplantation to the physiological processes of microchimerism and the microbiome. Beyond origin narratives that concentrate on host' and guest' and self' and other', she examines the transformative possibilities that prostheses offer as they extend the nature of the embodied self beyond genetic singularity. Building on cutting-eTrade ReviewMargrit Shildrick is an important and original thinker whose work brilliantly brings together bioethics, feminist and queer theories, and critical disability studies. In Visceral Prostheses, Shildrick extends her thinking on posthuman embodiment into new territories, including the microbiome and microchimerism. Her analyses of various case studies of prostheses as both external and internal to corporeality takes feminist thought in new directions. * Lisa Diedrich, Professor of Women’s, Gender, and Sexuality Studies, Stony Brook University, USA *A fascinating reconceptualization of the notion of prosthesis through the lens of critical disability studies that views a range of contemporary medical interventions involving live but non-self materials as visceral prostheses requiring a reconceptualization of the human body as open to creative expansion. To frame stem cell transplants, heart and liver transplants, or even fecal transplants as prosthetics is reframes our conventional understanding of prosthetics as remedying a lack. Instead, these are all seen as journeys into a new realm of problematized and extended selfhood. For those engaged in critical disability studies, this reconfiguration of prosthesis is exciting. And for scholars engaged in studying biomedical innovations, the foundational role played by critical disability studies in this analysis of new biomedical strategies promises to reorient medicine in productive ways. * Susan M. Squier, Brill Professor Emeritus of English and Women's, Gender, and Sexuality Studies, Penn State University, USA *Table of ContentsAcknowledgments Introduction Part 1: From Mechanical To Visceral Prostheses Chapter 1: Disability Chapter 2: Organ And Tissue Transplantation Chapter 3: Microchimerism And The Microbiome Part 2: Some Case Studies Chapter 4: Dementia Chapter 5: Stem Cell Transplant Chapter 6: Surrogacy Part 3: Towards Posthuman Embodiment Chapter 7: Life And Death Chapter 8: The Ethics Of A New Imaginary Conclusion References Index
£28.99
Springer Microorganisms in Foods 8
Book SynopsisPreface.- Contributors and Reviewers.- Abbreviations Used in the Book.- Part I. Principles of Using Data in Microbial Control.- 1. Utility of Microbial Testing for Safety and Quality.- 2. Validation of Control Measures.- 3. Verification of Process Control.- 4. Verification of Environmental Control.- 5. Corrective Actions to Re-Establish Control.- 6. Microbiological Testing in Customer-Supplier Relations.- Part II. Applications of Principles to Product Categories.- 7. Applications and Use of Criteria and Other Tests.- 8. Meat Products.- 9 Poultry Products.- 10. Fish and Seafood Products.- 11. Feeds and Pet Food.- 12. Vegetablesand Vegetable Products.- 13. Fruits and Fruit Products.- 14. Spice, Dry Soups and Asian Flavorings.- Cereals and Cereal Products.- 16. Nuts, Oilseeds, Dried Legumes and Coffee.- 17. Cocoa, Chocolate and Confectionary.- 18. Oil- and Fat-based Foods.- 19. Sugar, Syrups and Honey.- 20. Non-Alcoholic Beverages.- 21. Water.- 22. Eggs and Egg Products.- 23. Milk and DaiTrade Review"Microorganisms in Foods 8 is a virtual gold mine for all who wish to make themselves familiar with current approaches and policy of microbial food safety, or to update their knowledge on the subject...The ICMSF has established itself as a leading source of independent and impartial scientific advice to international standard setting bodies and national governments and industry. [Microorganisms in Foods 8] is a noble piece of work, which adds to this reputation."-Niels Skovgaard, International Journal of Food Microbiology"A...reference book that I believe should be in every food processor's library."-Ron Wasik, President of RJW Consulting Canada, Ltd.Table of ContentsPreface.- Contributors and Reviewers.- Abbreviations Used in the Book.- Part I. Principles of Using Data in Microbial Control.- 1. Utility of Microbial Testing for Safety and Quality.- 2. Validation of Control Measures.- 3. Verification of Process Control.- 4. Verification of Environmental Control.- 5. Corrective Actions to Re-Establish Control.- 6. Microbiological Testing in Customer-Supplier Relations.- Part II. Applications of Principles to Product Categories.- 7. Applications and Use of Criteria and Other Tests.- 8. Meat Products.- 9 Poultry Products.- 10. Fish and Seafood Products.- 11. Feeds and Pet Food.- 12. Vegetables and Vegetable Products.- 13. Fruits and Fruit Products.- 14. Spice, Dry Soups and Asian Flavorings.- Cereals and Cereal Products.- 16. Nuts, Oilseeds, Dried Legumes and Coffee.- 17. Cocoa, Chocolate and Confectionary.- 18. Oil- and Fat-based Foods.- 19. Sugar, Syrups and Honey.- 20. Non-Alcoholic Beverages.- 21. Water.- 22. Eggs and Egg Products.- 23. Milk and Dairy Products.- 24. Shelf-Table Heat Treated Foods.- 25. Dry Foods for Infants and Young Children.- 26. Combination Foods.- Appendix 1. Sampling Considerations and Statistical Aspects of Sampling Plans.- Appendix 2. Calculations for Chapter 2.- Appendix 3. ISO Methods Referenced in Tables.- Appendix 4. Objectives and Accomplishments of the ICMSF.- Appendix 5. ICMSF Participants.- Appendix 6. ICMSF Publications.- Appendix 7. Sponsors of ICMSF Activities.
£237.99
John Wiley and Sons Ltd Extrusion Processing Technology
Book SynopsisExtrusion is the operation of forming and shaping a molten or dough-like material by forcing it through a restriction, or die. It is applied and used in many batch and continuous processes. However, extrusion processing technology relies more on continuous process operations which use screw extruders to handle many process functions such as the transport and compression of particulate components, melting of polymers, mixing of viscous media, heat processing of polymeric and biopolymeric materials, product texturization and shaping, defibering and chemical impregnation of fibrous materials, reactive extrusion, and fractionation of solid-liquid systems. Extrusion processing technology is highly complex, and in-depth descriptions and discussions are required in order to provide a complete understanding and analysis of this area: this book aims to provide readers with these analyses and discussions. Extrusion Processing Technology: Food and Non-Food Biomaterials provides an ovTable of ContentsForeword ix Acknowledgements xi 1 Generic Extrusion Processes 1 1.1 A history of extrusion processing technology 1 1.1.1 The introduction of screw extruders 1 1.1.2 The generic extrusion process concept 2 1.1.3 Extrusion technology in the polymer-processing industry 3 1.1.4 Extrusion technology in the food- and feed-processing industry 4 1.1.5 Extrusion technology in the paper-milling industry 8 1.2 Factors driving the development of extrusion processing technology 9 1.2.1 Process productivity 9 1.2.2 Product innovation and functionality 9 1.2.3 Environmentally friendly processing 10 1.3 The industrial and economic importance of extrusion processing technology 10 1.3.1 In the polymer and plastics industry 10 1.3.2 In the food and feed industry 10 1.3.3 In the paper milling industry 11 1.4 Contents and structure of the book 11 References 12 2 Extrusion Equipment 13 2.1 Extruders 13 2.1.1 The kinematics of extruders 13 2.1.2 The screw-barrel assembly 15 2.1.3 The die assembly 20 2.1.4 The central operating cabinet 28 2.2 Extruder screw-barrel configurations 28 2.2.1 Single screw extruders 29 2.2.2 Intermeshing co-rotating twin screw extruders 31 2.2.3 Screw-barrel configuration and wear 33 2.3 Ancillary equipment 39 2.3.1 Upstream ancillary equipment 40 2.3.2 On-line ancillary equipment 44 2.3.3 Downstream ancillary equipment 46 References 51 3 Extrusion Engineering 53 3.1 Thermomechanical processing in screw extruders 53 3.1.1 Process configuration of single screw extruders 53 3.1.2 Process configuration of intermeshing co-rotating twin screw extruders 55 3.1.3 Processing specificities 56 3.2 Thermomechanical flow in screw extruders 58 3.2.1 Modeling approaches 58 3.2.2 Solids conveying section 67 3.2.3 Melt conveying section 72 3.2.4 Single screw extrusion versus twin screw extrusion 110 3.3 Thermomechanical extrusion processing: use of numerical methods 115 3.3.1 Single screw extrusion 115 3.3.2 Twin screw extrusion 118 3.3.3 Commercial software 120 References 122 4 The Generic Extrusion Process I: Thermomechanical Plasticating of Polymers and Polymer Melt Forming 125 4.1 The bio-based polymers and bio-based plastics 126 4.1.1 Definitions 126 4.1.2 Macromolecular characteristics of bio-based polymers 129 4.2 Melting mechanism of polymer materials in screw extruders 138 4.2.1 Melting mechanism in single screw extruders: qualitative description 139 4.2.2 Engineering analysis of polymer melting in single screw extruders 140 4.2.3 Melting mechanism in intermeshing co-rotating twin screw extruders 143 4.2.4 Polymer melting: single screw extrusion versus twin screw extrusion 146 4.3 Physical transitions of bio-based polymers 147 4.3.1 Physical transitions of polymeric materials: generalities 147 4.3.2 Glass and melting transitions: basics 149 4.3.3 Glass and melting transitions of bio-based polymers 151 4.4 Flow properties of bio-based polymer melts 157 4.4.1 Flow behavior: basics 157 4.4.2 Measurement of flow properties of polymer melts 159 4.4.3 Rheological characteristics of bio-based polymer melts 161 4.5 Case studies: emerging applications 162 4.5.1 Melting of polyamide-11 in a single screw extruder: exercise 162 4.5.2 Extrusion processing of biodegradable starch-based loose-fill packaging foams 163 4.5.3 Extrusion compounding of flax fiber-reinforced thermoplastics 165 References 168 5 The Generic Extrusion Process II: Thermomechanical Micromixing and Reactive Extrusion 173 5.1 Reactive extrusion: qualitative description 174 5.1.1 Bulk polymerization 174 5.1.2 Reactive processing of polymers. Reactive plastics reprocessing 175 5.1.3 Reactive extrusion in classic organic chemistry 177 5.1.4 Reactive solid-liquid extrusion-pressing 178 5.1.5 Processing characteristics of reactive extrusion 178 5.2 Reactive extrusion: chemical reaction engineering approach 179 5.2.1 The continuous plug flow reactor 181 5.2.2 Mixing in screw extruder-reactors 189 5.2.3 Heat transfer mechanisms in extruder-reactors 206 5.2.4 Coupling of transport phenomena and chemical reactions 210 5.2.5 Basic principles of process engineering in reactive extrusion 213 5.3 Reactive extrusion applications and processing lines 215 5.3.1 The classes of chemical reactions in reactive extrusion 215 5.3.2 Case study 1: casein-to-caseinate extrusion processing 217 5.3.3 Case study 2: extrusion pulping of non-wood fibers 220 5.3.4 Case study 3: enzymatic hydrolysis of starch 225 References 238 6 The Generic Extrusion Process III: Thermomechanical Cooking and Food Product Texturization 243 6.1 Food extrusion-cooking: qualitative description 244 6.1.1 Thermomechanical cooking of biopolymer-based systems 244 6.1.2 Texturization of extrusion-cooked melts 254 6.2 Engineering analysis of process functions 255 6.2.1 Preconditioning 255 6.2.2 Extrusion-cooking 261 6.2.3 Steam-induced die texturization 276 6.3 Examples of industrial applications: food extrusion processing lines 293 6.3.1 Breakfast cereals extrusion processing 294 6.3.2 Aquafeed extrusion-cooking process 300 6.3.3 High-moisture extrusion-cooking process 304 References 306 7 Quality Analysis of Extrusion-Textured Food Products 311 7.1 Methods of thermomechanical cooking analysis 311 7.1.1 Optical microscopy for birefringence analysis 312 7.1.2 Water solubility (WSI) and absorption (WAI) indices 312 7.1.3 Alkaline viscosity 313 7.1.4 Differential scanning calorimetry 313 7.1.5 Rapid Visco™ Analyzer 314 7.2 Methods of characterizing extrudate texture 327 7.2.1 Measurement of product density 327 7.2.2 Measurement of structural characteristics 328 7.2.3 Measurement of mechanical characteristics 334 7.2.4 Physical texture of directly expanded extrudates 342 7.3 Case study: texture monitoring of directly expanded extrudates 343 7.3.1 Main features of process–product relationships 343 7.3.2 Methodology for texture monitoring 344 7.3.3 Master correlations between sensory attributes and puncture parameter 346 References 348 8 The Generic Extrusion Process IV: Thermomechanical Pretreatment and Solid–Liquid Separation 351 8.1 The fourth Generic Extrusion Process: continuous mechanical expression 352 8.2 Engineering analysis of thermomechanical expression 356 8.2.1 Structure of cellular biological materials 357 8.2.2 Introduction of the nomenclature 359 8.2.3 General description of the filtration and consolidation processes 363 8.2.4 Rheological properties of cellular biological materials and their characterization 367 8.3 Process modeling 370 8.3.1 The fluid mechanics of the process and determination of relevant parameters 370 8.3.2 Effects of material properties on the process yield 375 8.3.3 Effects of processing conditions and screw geometry on pressure build-up and liquid expression 378 8.4 Case studies: examples of industrial applications 381 8.4.1 Continuous screw extrusion-pressing of copra, a hard cellular material 382 8.4.2 Continuous screw extrusion-pressing of groundnuts/peanuts, a soft cellular material 382 8.4.3 Soybean processing 383 8.4.4 Feed pretreatments 386 References 390 9 The Generic Extrusion Process V: Thermophysical Micromixing and Material Porosification 393 9.1 The new generic extrusion-porosification process 395 9.1.1 Typical drying processes for instant powders 395 9.1.2 Main drivers of instant powder drying 417 9.1.3 The extrusion-porosification process 421 9.2 Engineering discussion of process functions 425 9.2.1 Vacuum evaporation 426 9.2.2 Twin screw extrusion-aeration 440 9.2.3 Intensified spray drying 450 9.3 Perspectives on industrial applications 451 9.3.1 Range of applications 451 9.3.2 Case study: extrusion-porosification of dairy products 453 References 459 10 Extrusion Technology and Process Intensification 465 10.1 From sustainable development to process intensification 465 10.1.1 The IPAT equation 466 10.1.2 Sustainable development 467 10.1.3 Sustainable technology 469 10.1.4 Concept of process intensification 470 10.2 Process intensification in extrusion processing technology 472 10.2.1 Characteristic times of process phenomena 473 10.2.2 Process-intensifying methods in extrusion 474 10.2.3 Sustainability of extrusion processing technology 497 10.3 Case studies: exercises 499 10.3.1 Exercise 1: Residence time distribution 499 10.3.2 Exercise 2: Polymer melt coupling in reactive extrusion 501 10.3.3 Exercise 3: Weighted average total strain 502 10.3.4 Exercise 4: Energy saving in extrusion-cooking 503 10.3.5 Exercise 5: Water saving in solid-liquid extrusion-pressing 503 10.4 Conclusion: future trends 504 References 505 Index 507
£140.55
Lulu Press Biotechnology
£20.06
iUniverse Vagus Nerve Stimulation and Anxiety
Book Synopsis
£14.58
Lulu.com The Rhizosphere
£22.05
Taylor & Francis Inc An Introduction to Polysaccharide Biotechnology
Book SynopsisPolysaccharides and related high molecular weight glycans are hugely diverse with wide application in Biotechnology and great opportunities for further exploitation. An Introduction to Polysaccharide Biotechnology a second edition of the popular original text by Tombs and Harding introduces students, researchers, clinicians and industrialists to the properties of some of the key materials involved, how these are applied, some of the economic factors concerning their production and how they are characterized for regulatory purposes.Table of ContentsPolysaccharides and their Potential for Biotechnology. Structural Polysaccharides. Storage Polysaccharides: Starch and Fructans. Marine Polysaccharides. Some Bacterial and Synthetic Polysaccharides. Vaccines, Encapsulation, Bioactivity. Regulatory Issues. Glycans. Scaffolding. Modern Applications.
£999.99
de Gruyter Biofabrication
£65.25
Createspace Independent Publishing Platform ISO 13485 - the Quality Management System for Medical Devices: Understanding Quality, Risk and Design Control
£18.74
Artech House Publishers Medical Device Software Verification, Validation, and Compliance
£113.00
Artech House Publishers Principles of Biomedical Engineering, Second Edition
Book SynopsisThis updated edition of an Artech House classic introduces readers to the importance of engineering in medicine. Bioelectrical phenomena, principles of mass and momentum transport to the analysis of physiological systems, the importance of mechanical analysis in biological tissues/ organs and biomaterial selection are discussed in detail. Readers learn about the concepts of using living cells in various therapeutics and diagnostics, compartmental modeling, and biomedical instrumentation. The book explores fluid mechanics, strength of materials, statics and dynamics, basic thermodynamics, electrical circuits, and material science. A significant number of numerical problems have been generated using data from recent literature and are given as examples as well as exercise problems. These problems provide an opportunity for comprehensive understanding of the basic concepts, cutting edge technologies and emerging challenges.Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics. Structured as a complete text for students with some engineering background, the book also makes a valuable reference for professionals new to the bioengineering field. This authoritative textbook features numerous exercises and problems in each chapter to help ensure a solid understanding of the material.Table of ContentsIntroduction; Biotransport; Bioelectrical Phenomena; Biofluid flow; Biomechanics; Biomaterials; Cellular Engineering; Biomedical Imaging; Modeling Complex Systems; Ethics and Regulatory Affairs.
£129.75
Callisto Reference Molecular Biotechnology
£99.68
Callisto Reference Animal Husbandry and Biotechnology
£101.70
Callisto Reference Industrial Biotechnology and Microbiology
£105.30
Callisto Reference Biological Engineering: Design, Materials and Systems
£99.68
Callisto Reference Genetic Modification: Methods and Techniques
£98.32
Callisto Reference Bionanotechnology
£98.32
Callisto Reference Environmental Biotechnology: Theory, Concepts and Applications
£99.68
Callisto Reference Bioengineering: Tools, Methods and Applications
£94.05
Callisto Reference Animal Biotechnology
£98.55
Callisto Reference Theory, Processes and Applications of Biotechnology
£98.55
Callisto Reference Biochemistry: Principles and Applications
£95.85
