Biology, life sciences Books
John Wiley and Sons Ltd Systematics
Book SynopsisSystematics: A Course of Lectures is designed for use in an advanced undergraduate or introductory graduate level course in systematics and is meant to present core systematic concepts and literature. The book covers topics such as the history of systematic thinking and fundamental concepts in the field including species concepts, homology, and hypothesis testing. Analytical methods are covered in detail with chapters devoted to sequence alignment, optimality criteria, and methods such as distance, parsimony, maximum likelihood and Bayesian approaches. Trees and tree searching, consensus and super-tree methods, support measures, and other relevant topics are each covered in their own sections. The work is not a bleeding-edge statement or in-depth review of the entirety of systematics, but covers the basics as broadly as could be handled in a one semester course. Most chapters are designed to be a single 1.5 hour class, with those on parsimony, likelihood, posterior probabiliTrade Review“Viewed as a series of lectures, this is clearly aimed at graduate level courses in systematics, although some elements would prove useful at undergraduate level.” (British Ecological Society Bulletin, 1 August 2013) “If you want to teach yourself systematics, this book is for you. It’s just a series of lectures and exercises compiled by Wheeler, one of the top systematic biologists.” (Teaching Biology, 20 December 2012) “All things considered, I strongly recommend this work as a textbook for those teaching in systematics, biologists and palaeontologists alike . . . I would advise this book to graduate students – MSc and above.” (Journal of Zoological Systematics and Evolutionary Research, 1 February 2013)Table of ContentsPreface xv Using these notes xv Acknowledgments xvi List of algorithms xix I Fundamentals 1 1 History 2 1.1 Aristotle 2 1.2 Theophrastus 3 1.3 Pierre Belon 4 1.4 Carolus Linnaeus 4 1.5 Georges Louis Leclerc, Comte de Buffon 6 1.6 Jean-Baptiste Lamarck 7 1.7 Georges Cuvier 8 1.8 ´Etienne Geoffroy Saint-Hilaire 8 1.9 JohannWolfgang von Goethe 8 1.10 Lorenz Oken 9 1.11 Richard Owen 9 1.12 Charles Darwin 9 1.13 Stammb¨aume 12 1.14 Evolutionary Taxonomy 14 1.15 Phenetics 15 1.16 Phylogenetic Systematics 16 1.16.1 Hennig’s Three Questions 16 1.17 Molecules and Morphology 18 1.18 We are all Cladists 18 1.19 Exercises 19 2 Fundamental Concepts 20 2.1 Characters 20 2.1.1 Classes of Characters and Total Evidence 22 2.1.2 Ontogeny, Tokogeny, and Phylogeny 23 2.1.3 Characters and Character States 23 2.2 Taxa 26 2.3 Graphs, Trees, and Networks 28 2.3.1 Graphs and Trees 30 2.3.2 Enumeration 31 2.3.3 Networks 33 2.3.4 Mono-, Para-, and Polyphyly 33 2.3.5 Splits and Convexity 38 2.3.6 Apomorphy, Plesiomorphy, and Homoplasy 39 2.3.7 Gene Trees and Species Trees 41 2.4 Polarity and Rooting 43 2.4.1 Stratigraphy 43 2.4.2 Ontogeny 43 2.4.3 Outgroups 45 2.5 Optimality 49 2.6 Homology 49 2.7 Exercises 50 3 Species Concepts, Definitions, and Issues 53 3.1 Typological or Taxonomic Species Concept 54 3.2 Biological Species Concept 54 3.2.1 Criticisms of the BSC 55 3.3 Phylogenetic Species Concept(s) 56 3.3.1 Autapomorphic/Monophyletic Species Concept 56 3.3.2 Diagnostic/Phylogenetic Species Concept 58 3.4 Lineage Species Concepts 59 3.4.1 Hennigian Species 59 3.4.2 Evolutionary Species 60 3.4.3 Criticisms of Lineage-Based Species 61 3.5 Species as Individuals or Classes 62 3.6 Monoism and Pluralism 63 3.7 Pattern and Process 63 3.8 Species Nominalism 64 3.9 Do Species Concepts Matter? 65 3.10 Exercises 65 4 Hypothesis Testing and the Philosophy of Science 67 4.1 Forms of Scientific Reasoning 67 4.1.1 The Ancients 67 4.1.2 Ockham’s Razor 68 4.1.3 Modes of Scientific Inference 69 4.1.4 Induction 69 4.1.5 Deduction 69 4.1.6 Abduction 70 4.1.7 Hypothetico-Deduction 71 4.2 Other Philosophical Issues 75 4.2.1 Minimization, Transformation, and Weighting 75 4.3 Quotidian Importance 76 4.4 Exercises 76 5 Computational Concepts 77 5.1 Problems, Algorithms, and Complexity 77 5.1.1 Computer Science Basics 77 5.1.2 Algorithms 79 5.1.3 Asymptotic Notation 79 5.1.4 Complexity 80 5.1.5 Non-Deterministic Complexity 82 5.1.6 Complexity Classes: P and NP 82 5.2 An Example: The Traveling Salesman Problem 84 5.3 Heuristic Solutions 85 5.4 Metricity, and Untrametricity 86 5.5 NP–Complete Problems in Systematics 87 5.6 Exercises 88 6 Statistical and Mathematical Basics 89 6.1 Theory of Statistics 89 6.1.1 Probability 89 6.1.2 Conditional Probability 91 6.1.3 Distributions 92 6.1.4 Statistical Inference 98 6.1.5 Prior and Posterior Distributions 99 6.1.6 Bayes Estimators 100 6.1.7 Maximum Likelihood Estimators 101 6.1.8 Properties of Estimators 101 6.2 Matrix Algebra, Differential Equations, and Markov Models 102 6.2.1 Basics 102 6.2.2 Gaussian Elimination 102 6.2.3 Differential Equations 104 6.2.4 Determining Eigenvalues 105 6.2.5 MarkovMatrices 106 6.3 Exercises 107 II Homology 109 7 Homology 110 7.1 Pre-Evolutionary Concepts110 7.1.1 Aristotle 110 7.1.2 Pierre Belon 110 7.1.3 ´Etienne Geoffroy Saint-Hilaire 111 7.1.4 Richard Owen 112 7.2 Charles Darwin 113 7.3 E. Ray Lankester 114 7.4 Adolf Remane 114 7.5 Four Types of Homology 115 7.5.1 Classical View 115 7.5.2 Evolutionary Taxonomy 115 7.5.3 Phenetic Homology 116 7.5.4 Cladistic Homology 116 7.5.5 Types of Homology 117 7.6 Dynamic and Static Homology 118 7.7 Exercises 120 8 Sequence Alignment 121 8.1 Background 121 8.2 “Informal” Alignment 121 8.3 Sequences 121 8.3.1 Alphabets 122 8.3.2 Transformations 123 8.3.3 Distances 123 8.4 Pairwise StringMatching 123 8.4.1 An Example 127 8.4.2 Reducing Complexity 129 8.4.3 Other Indel Weights 130 8.5 Multiple Sequence Alignment 131 8.5.1 The Tree Alignment Problem 133 8.5.2 Trees and Alignment 133 8.5.3 Exact Solutions 134 8.5.4 Polynomial Time Approximate Schemes 134 8.5.5 Heuristic Multiple Sequence Alignment 134 8.5.6 Implementations 135 8.5.7 Structural Alignment 139 8.6 Exercises 145 III Optimality Criteria 147 9 Optimality Criteria−Distance 148 9.1 Why Distance? 148 9.1.1 Benefits 149 9.1.2 Drawbacks 149 9.2 Distance Functions 150 9.2.1 Metricity 150 9.3 Ultrametric Trees 150 9.4 Additive Trees 152 9.4.1 Farris Transform 153 9.4.2 Buneman Trees 154 9.5 General Distances 156 9.5.1 Phenetic Clustering 157 9.5.2 Percent Standard Deviation 160 9.5.3 Minimizing Length 163 9.6 Comparisons 170 9.7 Exercises 171 10 Optimality Criteria−Parsimony 173 10.1 Perfect Phylogeny 174 10.2 Static Homology Characters 174 10.2.1 Additive Characters 175 10.2.2 Non-Additive Characters 179 10.2.3 Matrix Characters 182 10.3 Missing Data 184 10.4 Edge Transformation Assignments 187 10.5 Collapsing Branches 188 10.6 Dynamic Homology 188 10.7 Dynamic and Static Homology 189 10.8 Sequences as Characters 190 10.9 The Tree Alignment Problem on Trees 191 10.9.1 Exact Solutions 191 10.9.2 Heuristic Solutions 191 10.9.3 Lifted Alignments, Fixed-States, and Search-Based Heuristics 193 10.9.4 Iterative Improvement 197 10.10 Performance of Heuristic Solutions 198 10.11 Parameter Sensitivity 198 10.11.1 Sensitivity Analysis 199 10.12 Implied Alignment 199 10.13 Rearrangement 204 10.13.1 Sequence Characters with Moves 204 10.13.2Gene Order Rearrangement 205 10.13.3Median Evaluation 207 10.13.4Combination ofMethods 207 10.14 Horizontal Gene Transfer, Hybridization, and Phylogenetic Networks 209 10.15 Exercises 210 11 Optimality Criteria−Likelihood 213 11.1 Motivation 213 11.1.1 Felsenstein’s Example 213 11.2 Maximum Likelihood and Trees 216 11.2.1 Nuisance Parameters 216 11.3 Types of Likelihood 217 11.3.1 Flavors ofMaximum Relative Likelihood 217 11.4 Static-Homology Characters 218 11.4.1 Models 218 11.4.2 Rate Variation 219 11.4.3 Calculating p(D|T, θ) 221 11.4.4 Links Between Likelihood and Parsimony 222 11.4.5 A Note onMissing Data 224 11.5 Dynamic-Homology Characters 224 11.5.1 Sequence Characters 225 11.5.2 CalculatingML Pairwise Alignment 227 11.5.3 MLMultiple Alignment 230 11.5.4 Maximum Likelihood Tree Alignment Problem 230 11.5.5 Genomic Rearrangement 232 11.5.6 Phylogenetic Networks 234 11.6 Hypothesis Testing 234 11.6.1 Likelihood Ratios 234 11.6.2 Parameters and Fit 236 11.7 Exercises 238 12 Optimality Criteria−Posterior Probability 240 12.1 Bayes in Systematics 240 12.2 Priors 241 12.2.1 Trees 241 12.2.2 Nuisance Parameters 242 12.3 Techniques 246 12.3.1 Markov ChainMonte Carlo 246 12.3.2 Metropolis–Hastings Algorithm 246 12.3.3 Single Component 248 12.3.4 Gibbs Sampler 249 12.3.5 Bayesian MC3 249 12.3.6 Summary of Posterior 250 12.4 Topologies and Clades 252 12.5 Optimality versus Support 254 12.6 Dynamic Homology 254 12.6.1 Hidden Markov Models 255 12.6.2 An Example 256 12.6.3 Three Questions—Three Algorithms 258 12.6.4 HMMAlignment 262 12.6.5 Bayesian Tree Alignment 264 12.6.6 Implementations 264 12.7 Rearrangement 266 12.8 Criticisms of BayesianMethods 267 12.9 Exercises 267 13 Comparison of Optimality Criteria 269 13.1 Distance and CharacterMethods 269 13.2 Epistemology 270 13.2.1 Ockham’s Razor and Popperian Argumentation 271 13.2.2 Parsimony and the Evolutionary Process 272 13.2.3 Induction and Statistical Estimation 272 13.2.4 Hypothesis Testing and Optimality Criteria 272 13.3 Statistical Behavior 273 13.3.1 Probability 273 13.3.2 Consistency 274 13.3.3 Efficiency 281 13.3.4 Robustness 282 13.4 Performance 282 13.4.1 Long-Branch Attraction 283 13.4.2 Congruence 285 13.5 Convergence 285 13.6 CanWe Argue Optimality Criteria? 286 13.7 Exercises 287 IV Trees 289 14 Tree Searching 290 14.1 Exact Solutions 290 14.1.1 Explicit Enumeration 290 14.1.2 Implicit Enumeration—Branch-and-Bound 292 14.2 Heuristic Solutions 294 14.2.1 Local versus Global Optima 294 14.3 Trajectory Search 296 14.3.1 Wagner Algorithm 296 14.3.2 Branch-Swapping Refinement 298 14.3.3 Swapping as Distance 301 14.3.4 Depth-First versus Breadth-First Searching 302 14.4 Randomization 304 14.5 Perturbation 305 14.6 Sectorial Searches and Disc-Covering Methods 309 14.6.1 Sectorial Searches 309 14.6.2 Disc-CoveringMethods 310 14.7 Simulated Annealing 312 14.8 Genetic Algorithm 316 14.9 Synthesis and Stopping 318 14.10 Empirical Examples 319 14.11 Exercises 323 15 Support 324 15.1 ResamplingMeasures 324 15.1.1 Bootstrap 325 15.1.2 Criticisms of the Bootstrap 326 15.1.3 Jackknife 328 15.1.4 Resampling and Dynamic Homology Characters 329 15.2 Optimality-BasedMeasures 329 15.2.1 Parsimony 330 15.2.2 Likelihood 332 15.2.3 Bayesian Posterior Probability 334 15.2.4 Strengths of Optimality-Based Support 335 15.3 Parameter-BasedMeasures 336 15.4 Comparison of Support Measures—Optimal and Average 336 15.5 Which to Choose? 339 15.6 Exercises 339 16 Consensus, Congruence, and Supertrees 341 16.1 Consensus TreeMethods 341 16.1.1 Motivations 341 16.1.2 Adams I and II 341 16.1.3 Gareth Nelson 344 16.1.4 Majority Rule 347 16.1.5 Strict 347 16.1.6 Semi-Strict/Combinable Components 348 16.1.7 Minimally Pruned 348 16.1.8 When to UseWhat? 350 16.2 Supertrees 350 16.2.1 Overview 350 16.2.2 The Impossibility of the Reasonable 350 16.2.3 Graph-BasedMethods 353 16.2.4 Strict Consensus Supertree 355 16.2.5 MR-Based 355 16.2.6 Distance-Based Method 358 16.2.7 Supertrees or Supermatrices? 360 16.3 Exercises 361 V Applications 363 17 Clocks and Rates 364 17.1 The Molecular Clock 364 17.2 Dating 365 17.3 Testing Clocks 365 17.3.1 Langley–Fitch 365 17.3.2 Farris 366 17.3.3 Felsenstein 367 17.4 Relaxed ClockModels 368 17.4.1 Local Clocks 368 17.4.2 Rate Smoothing 368 17.4.3 Bayesian Clock 369 17.5 Implementations 369 17.5.1 r8s 369 17.5.2 MULTIDIVTIME 370 17.5.3 BEAST 370 17.6 Criticisms 370 17.7 Molecular Dates? 373 17.8 Exercises 373 A Mathematical Notation 374 Bibliography 376 Index 415 Color plate section between pp. 76 and 77
£999.99
John Wiley and Sons Ltd Decision Making in Natural Resource Management
Book SynopsisThis book is intended for use by natural resource managers and scientists, and students in the fields of natural resource management, ecology, and conservation biology, who are confronted with complex and difficult decision making problems. The book takes readers through the process of developing a structured approach to decision making, by firstly deconstructing decisions into component parts, which are each fully analyzed and then reassembled to form a working decision model. The book integrates common-sense ideas about problem definitions, such as the need for decisions to be driven by explicit objectives, with sophisticated approaches for modeling decision influence and incorporating feedback from monitoring programs into decision making via adaptive management. Numerous worked examples are provided for illustration, along with detailed case studies illustrating the authors' experience in applying structured approaches. There is also a series of detailed technical appendices. AnTrade Review“An easily readable and coherent account, this book has a definite role on the shelf (and its outline content in the minds) of conservation decision-makers and advisors.” (African Journal of Range & Forage Science, 1 October 2015) “This is one of the best resources on structured decision-making I have found – specifically tailored for those working in or studying in the fields of ecology, NRM, land management and conservation biology.” (Ecological Management & Restoration, 20 January 2015) “I highly recommend this book to resource managers, scientists, students, and anyone who faces difficult, complex, or uncertain decisions that would benefit from adopting a structured approach to decision making.” (The Journal of Wildlife Management, 8 November 2013) “I highly recommend the very results oriented and working model based book Decision Making in Natural Resource Management: A Structured, Adaptive Approach by Michael J. Conroy and James T. Peterson, to any natural resource managers, scientists, government policy makers, business leaders, conservation groups, and students of natural resource management, ecology, and conservation biology who are seeking a complete guide to structured and effective decision making in the area of natural resource management. This book will guide leaders toward better decisions, through a more integrated examination of the real problems to find viable and effective solutions.” (Blog Business World, 5 April 2013) Table of ContentsList of boxes xi Preface xiii Acknowledgements xiv Guide to using this book xv Companion website xvii PART I. INTRODUCTION TO DECISION MAKING 1 1 Introduction: Why a Structured Approach in Natural Resources? 3 The role of decision making in natural resource management 4 Common mistakes in framing decisions 5 What is structured decision making (SDM)? 6 Why should we use a structured approach to decision making? 7 Limitations of the structured approach to decision making 8 Adaptive resource management 9 Summary 10 References 10 2 Elements of Structured Decision Making 13 First steps: defining the decision problem 13 General procedures for structured decision making 15 Predictive modeling: linking decisions to objectives prospectively 17 Uncertainty and how it affects decision making 18 Dealing with uncertainty in decision making 21 Summary 23 References 23 3 Identifying and Quantifying Objectives in Natural Resource Management 24 Identifying objectives 24 Identifying fundamental and means objectives 25 Clarifying objectives 28 Separating objectives from science 29 Barriers to creative decision making 30 Types of fundamental objectives 32 Identifying decision alternatives 34 Quantifying objectives 38 Dealing with multiple objectives 38 Multi-attribute valuation 41 Utility functions 43 Other approaches 50 Additional considerations 52 Decision, objectives, and predictive modeling 55 References 55 4 Working with Stakeholders in Natural Resource Management 57 Stakeholders and natural resource decision making 57 Stakeholder analysis 59 Stakeholder governance 62 Working with stakeholders 68 Characteristics of good facilitators 68 Getting at stakeholder values 71 Stakeholder meetings 72 The first workshop 74 References 76 Additional reading 76 PART II. TOOLS FOR DECISION MAKING AND ANALYSIS 77 5 Statistics and Decision Making 79 Basic statistical ideas and terminology 80 Using data in statistical models for description and prediction 100 Linear models 104 Hierarchical models 116 Bayesian inference 129 Resampling and simulation methods 140 Statistical significance 145 References 146 Additional reading 146 6 Modeling the Influence of Decisions 147 Structuring decisions 147 Influence diagrams 148 Frequent mistakes when structuring decisions 153 Defining node states 157 Decision trees 159 Solving a decision model 160 Conditional independence and modularity 164 Parameterizing decision models 165 Elicitation of expert judgment 179 Quantifying uncertainty in expert judgment 188 Group elicitation 189 The care and handling of experts 190 References 191 Additional reading 191 7 Identifying and Reducing Uncertainty in Decision Making 192 Types of uncertainty 192 Irreducible uncertainty 193 Reducible uncertainty 194 Effects of uncertainty on decision making 197 Sensitivity analysis 203 Value of information 217 Reducing uncertainty 220 References 230 Additional reading 231 8 Methods for Obtaining Optimal Decisions 232 Overview of optimization 233 Factors affecting optimization 234 Multiple attribute objectives and constrained optimization 239 Dynamic decisions 246 Optimization under uncertainty 249 Analysis of the decision problem 253 Suboptimal decisions and “satisficing” 256 Other problems 257 Summary 258 References 258 PART III. APPLICATIONS 261 9 Case Studies 263 Case study 1 Adaptive Harvest Management of American Black Ducks 263 Case study 2 Management of Water Resources in the Southeastern US 276 Case study 3 Regulation of Largemouth Bass Sport Fishery in Georgia 284 Summary 291 References 291 10 Summary, Lessons Learned, and Recommendations 294 Summary 294 Lessons learned 294 Structured decision making for Hector’s Dolphin conservation 295 Landowner incentives for conservation of early successional habitats in Georgia 298 Cahaba shiner 299 Other lessons 303 References 304 PART IV. APPENDICES 307 Appendix A Probability and Distributional Relationships 309 Probability axioms 309 Conditional probability 309 Conditional independence 310 Expected value of random variables 311 Law of total probability 311 Bayes’ theorem 312 Distribution moments 313 Sample moments 316 Additional reading 316 Appendix B Common Statistical Distributions 317 General distribution characteristics 317 Continuous distributions 320 Discrete distributions 329 Reference 338 Additional Reading 338 Appendix C Methods for Statistical Estimation 339 General principles of estimation 339 Method of moments 342 Least squares 343 Maximum likelihood 346 Bayesian approaches 353 References 372 Appendix D Parsimony, Prediction, and Multi-Model Inference 373 General approaches to multi-model inference 373 Multi-model inference and model averaging 376 Multi-model Bayesian inference 380 References 383 Appendix E Mathematical Approaches to Optimization 384 Review of general optimization principles 385 Classical programming 392 Nonlinear programming 397 Linear programming 399 Dynamic decision problems 402 Decision making under structural uncertainty 419 Generalizations of Markov decision processes 427 Heuristic methods 427 References 429 Appendix F Guide to Software 430 Appendix G Electronic Companion to Book 432 Glossary 433 Index 449
£999.99
John Wiley & Sons Inc Oogenesis
Book SynopsisOogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research. This bookdescribes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction. This volume is an esseTable of ContentsList of Contributors. Foreword. (Tim Hunt) Section I: Oocyte Determination. Chapter 1: The Sperm/Oocyte Decision, a C. elegans Perspective (Ronald Ellis). Chapter 2: Sex Determination and Gonadal Development (Alexander Combes, Cassy Spiller and Peter Koopman). Chapter 3 : Clytia hemisphaerica: A Cnidarian Model for Studying Oogenesis (Aldine Amiel, Patrick Chang, Tsuyoshi Momose and Evelyn Houliston). Section II: Oocyte Growth. Chapter 4: Soma–Germline Interactions in the Ovary: an Evolutionary Perspective (David Albertini and John Bromfield). Section III: Homologous Chromosome Pairing and Recombination. Chapter 5: Homologous Chromosome Pairing and Synapsis during Oogenesis (Susanna Mlynarczyk-Evans and Anne Villeneuve). Chapter 6: Meiotic Recombination in Mammals (Sabine Santucci-Darmanin and Fre´de´ric Baudat). Section IV: Meiosis Resumption. Chapter 7: Initiation of the Meiotic Prophase-to-Metaphase Transition in Mammalian Oocytes (Laurinda A. Jaffe and Rachael P. Norris). Chapter 8: Oocyte-Specific Translational Control Mechanisms (Isabel Novoa, Carolina Eliscovich, Eula`lia Belloc and Rau´l Me´ndez). Chapter 9: MPF and the Control of Meiotic Divisions: Old Problems, New Concepts (Catherine Jessus). Section V: The Cytological Events of Meiotic Divisions. Chapter 10: Meiotic Spindle Assembly and Chromosome Segregation in Oocytes (Julien Dumont and Ste´phane Brunet). Chapter 11: Mechanisms of Asymmetric Division in Metazoan Meiosis (Marie-He´le`ne Verlhac and Karen Wingman Lee). Section VI: Biological Clocks Regulating Meiotic Divisions. Chapter 12: The Control of the Metaphase-to-Anaphase Transition in Meiosis (M. Emilie Terret). Chapter 13: Mechanisms Controlling Maintenance and Exit of the CSF Arrest (Thierry Lorca and Anna Castro). Chapter 14: Cytostatic Arrest: Post-ovulation Arrest Until Fertilization in Metazoan Oocytes (Tomoko Nishiyama, Kazunori Tachibana and Takeo Kishimoto). Section VII: Oocyte Ageing in Mammals. Chapter 15: Mammalian Oocyte Population throughout Life (Roger Gosden, Eujin Kim, Bora Lee, Katia Manova and Malcolm Faddy). Section VIII: From Oocyte to Embryo. Chapter 16: Fertilization and the Evolution of Animal Gamete Proteins (Julian L. Wong and Gary M. Wessel). Chapter 17: Remodelling the Oocyte into a Totipotent Zygote: Degradation of Maternal Products (Jose´-Eduardo Gomes, Jorge Merlet, Julien Burger and Lionel Pintard). Chapter 18: Chromatin Remodelling in Mammalian Oocytes (Rabindranath De La Fuente, Claudia Baumann, Feikun Yang and Maria M. Viveiros). Chapter 19: Follicles and Medically Assisted Reproduction (Susan L. Barrett and Teresa K. Woodruff). Index.
£117.75
John Wiley & Sons Inc Molecular Analysis and Genome Discovery
Book SynopsisMolecular Analysis and Genome Discovery, Second Edition is a completely revised and updated new edition of this successful book. The text provides a comprehensive overview of recent developments in the fast moving field of molecular based diagnostics of disease markers. Key concepts and applications are provided alongside practical information on current techniques currently being researched and developed. Each chapter offers an up-to-date analysis of the subject encompassing the very latest technology platforms and is an essential reference for researchers in the field looking for an up-to-date overview of the subject. The book will also be an indispensable resource for those working in the biotechnology and pharmaceutical industries. New for this edition: chapters on Genotyping through Mutation Detection; Differential Gene Expression; Haplotyping and Molecular Profiling.Trade Review“It will be of immense value to students, biotechnologists, and scientists in the pharmaceutical industry. This update absolutely justifies replacement of the first edition.” (Doody’s, 24 August 2012)Table of ContentsPreface ix Contributors xi 1 Overview of Genotyping 1 Monica Bayes and Ivo Glynne Gut Introduction 1 Methods for interrogating SNPs 3 Commercial platforms for SNP genotyping 7 Practical recommendations 11 SNP databases 14 Methylation analysis 15 Copy number variation analysis 16 Second generation sequencing technologies 17 Conclusions 18 References 19 2 DNA Chip Analysis in Genome Discovery 24 Ross N. Nazar and Jane Robb Introduction 24 Interrogating a genome 25 Cross-species hybridization 28 Comparative genomic hybridization and microarray-based genotyping 31 Barcodes, DNA microarrays and organism identification 34 Concluding remarks 36 References 37 3 qPCR, Theory, Reliability and Use in Molecular Analysis 43 Jamie Murphy and Stephen A. Bustin Sample preparation 44 RNA quality 45 Reagents 46 Assay design 47 Transparency of published data 51 Further considerations 52 Conclusion 52 References 52 4 DNA Analysis in Droplet-Based Microfluidic Devices 56 Pinar Ozdemir and Yonghao Zhang Introduction 56 Continuous-flow microPCR chips 58 PCR inhibition and carryover contamination 62 PCR in droplets 65 Conclusions 73 References 75 5 High-Resolution Melt Profiling 81 Steven F. Dobrowolski and Carl T. Wittwer Introduction 81 Basic concepts of melt profiling 82 HRMP and polymerase chain reaction 84 DNA specimens and HRMP 89 Determining a temperature window for melting 90 Dyes and platforms for melt profiling 92 Scanning PCR products for sequence variation 93 Genotyping with high-resolution melt profiling 102 Other applications of HRMP 108 Final notes 109 References 110 6 Massively Parallel Sequencing 114 Tracy Tucker, Marco Marra and Jan M. Friedman Sanger sequencing 114 Massively parallel sequencing 114 Commercially available massively parallel sequencers 115 Future technologies 122 Paired-end or mate-paired reads 123 Target-enrichment strategies for MPS 124 Applications of MPS 125 Summary 131 References 132 7 Aptamers for Analysis: Nucleic Acids Ligands in the Post-Genomic Era 135 Pedro Nadal, Alessandro Pinto, Marketa Svobodova and Ciara K. O'Sullivan Introduction 135 SELEX 136 Aptamers in analysis 147 Imaging with aptamers 157 Conclusions, outlooks and perspectives 160 References 161 8 Use of Nanotechnology for Enhancing of Cancer Biomarker Discovery and Analysis: A Molecular Approach 175 Farid E. Ahmed Introduction 175 Proteomics and nanotechnology 176 Nanoscale multicomponent separation 176 Nanoscale protein detection strategies 178 Surface-enhanced Raman scattering (SERS) 182 References 188 9 Chip-Based Proteomics 193 Julian Bailes, Andrew Milnthorpe, Sandra Smieszek and Mikhail Soloviev Introduction 193 Lab-on-a-chip 194 Arrays 196 Chip-based mass spectrometry 203 Surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) chip instruments 205 Microfluidics 207 Conclusion 209 References 211 10 Antibody Microarrays in Proteome Profiling 219 Mohamed Saiel Saeed Alhamdani and Jorg D. Hoheisel Introduction 219 Technical aspects 220 Antibody array applications 226 Summary 229 Acknowledgements 229 References 229 11 Biomarker Detection and Molecular Profiling by Multiplex Microbead Suspension Array Based Immunoproteomics 244 V. V. Krishhan, Imran H. Khan and Paul A. Luciw Introduction 244 Principles of microbead-based multiplexing 245 Experimental aspects of the multiplex microbead assay 247 Multiplex microbead assay design and comparison with other methods 250 Applications of the multiplex microbead assay system for biomedical research and clinical studies 252 Selected investigational fields for multiplex analysis and examples of applications 255 Challenges and current limitations 255 Summary and future directions 259 Acknowledgements 261 References 261 12 Mass Spectrometry in Metabolomics 271 William J. Griffiths and Yuqin Wang Introduction 271 Sample collection and preparation 272 Data acquisition 274 Data analysis 279 Applications 283 Conclusion 294 Acknowledgement 294 References 295 Index 299
£106.35
John Wiley & Sons Inc Viruses and the Nucleus
Book SynopsisInterdisciplinary in approach, this definitive text on viral/nuclear interactions illustrates how viruses (positive and negative DNA and RNA) interact with the nucleus and its components to further viral replication, and the resulting consequences for the host cell.Table of ContentsContributors ix 1 The Nucleus – An Overview 1Dean A. Jackson 1.1 Introduction 1 1.2 The gene expression pathway in mammalian cells 2 1.3 Chromosome structure and DNA loops 9 1.4 Duplicating the genetic code 9 1.5 Nuclear compartmentalization 10 1.6 Nuclear architecture – implications for viral infection 18 1.7 Conclusion 19 References 20 2 The Eukaryotic Cell Cycle 25Jane V. Harper and Gavin Brooks 2.1 Introduction 25 2.2 The G0/G1 transition 31 2.3 The G1–S transition 32 2.4 S phase 39 2.5 The G2–M transition 45 2.6 Mitosis (M-phase) 48 2.7 Cytokinesis 52 2.8 Endoreduplication 53 2.9 Summary and conclusions 53 References 54 3 DNA Viruses and the Nucleus 69G. Eric Blair and Nicola James3.1 Introduction 69 3.2 The structure of the nucleus 70 3.3 DNA viruses and the nucleus 75 3.4 Concluding comments and future directions 81 References 81 4 Retroviruses and the Nucleus 89Carlos de Noronha and Warner C. Greene 4.1 Retroviral structure 91 4.2 The retroviral life cycle 91 4.3 Entering the nucleus 93 4.4 Inside the nucleus 101 4.5 Leaving the nucleus and the cell 113 4.6 Future perspectives 114 References 114 5 Negative-sense RNA Viruses and the Nucleus 129Debra Elton and Paul Digard 5.1 Introduction 129 5.2 The necessity of a nucleus 132 5.3 Nuclear import machinery 133 5.4 The cellular transcription machinery 135 5.5 Nuclear architecture 140 5.6 Nuclear export 143 5.7 Evasion of innate antiviral responses 147 References 148 6 Positive-strand RNA Viruses and the Nucleus 161Kurt E. Gustin and Peter Sarnow 6.1 Introduction 161 6.2 Replication of positive-strand RNA viruses in enucleated cells 162 6.3 Localization of viral proteins to the nucleus 163 6.4 Interaction of nuclear factors with viral proteins and nucleic acids 165 6.5 Cytoplasmic accumulation of nuclear proteins during infection 168 6.6 Disruption of nucleo-cytoplasmic trafficking by positive-strand RNA viruses 169 6.7 Advantages provided to the virus by inhibiting nuclear import 172 6.8 Conclusions 175 References 178 7 Viruses and the Nucleolus 185David A. Matthews and Julian A. Hiscox 7.1 Introduction 185 7.2 Techniques used to examine the nucleolus 191 7.3 Nucleolar localization signals (NoLS) 191 7.4 Viral interactions with the nucleolus 192 7.5 The nucleolus, viruses and autoimmunity 201 7.6 Summary 202 References 202 8 Virus Interactions with PML Nuclear Bodies 213Keith N. Leppard and John Dimmock 8.1 Introduction 213 8.2 ND10 in uninfected cells 213 8.3 Functions of ND10 217 8.4 ND10 and virus infection 219 8.5 Why do viruses interact with and modify ND10? 232 References 235 9 Viruses and the Cell Cycle 247Crisanto Gutierrez, Brian Dove and Julian A. Hiscox 9.1 Introduction: an overview of the eukaryotic cell cycle 247 9.2 DNA viruses and the cell cycle 249 9.3 Retroviruses and the cell cycle 254 9.4 RNA viruses and the cell cycle 255 9.5 Viruses, the nucleolus and cell cycle control 259 9.6 Viral interaction with activator protein-1 (AP-1) 259 9.7 Summary 260 References 262 Index 271
£81.65
John Wiley & Sons Inc Pathological Pain
Book SynopsisThis book brings together contributions from key investigators in the area of pathological pain.Trade Review"…an excellent book to review the electrophysiological and molecular aspects of pathological pain…can be of great value to both basic scientists and clinicians." (Annals of Neurology, August 2005)Table of ContentsChair's Introduction (Takao Kumazawa). Regulation Mechanisms of Vanilloid Receptors (Makoto Tominagaet, et al.). Sodium channels and neuropathic pain (Jin Mo Chung and Kyungsoon Chung). Ion channel activities implicated in pathological pain (John N. Wood, et al.). General Discussion I. Chronic pain and microglia: the role of ATP (Kazuhide Inoue, et al.). Neurotrophic influences on neuropathic pain (Stephen B. McMahon and William B. J. Cafferty). Changes in DRG neurons and spinal excitability in neuropathy (Koichi Noguchi, et al.). Functional reorganization of the spinal pain pathways in developmental and pathological conditions (M. Yoshimura, et al.). Central plasticity in pathological pain (Min Zhuo). General Discussion II. Anti-opioid systems in morphine tolerance and addiction: locus-specific involvement of nociceptin and NMDA receptor (Hiroshi Ueda). Chronic morphine-induced plasticity among signalling molecules (Alan R. Gintzler and Sumita Chakrabarti). Opioid tolerance and neuroplasticity (Jianren Mao). General Discussion III. A mechanism-based understanding of bone cancer pain (Patrick W. Mantyh). Mechanistic and clinical aspects of complex regional pain syndrome (CRPS)(Ralf Baron). Cortical pathophysiology of chronic pain (A. Vania Apkarian). Final Discussion: Translating basic research to the clinic. Index of contributors. Subject index.
£150.05
John Wiley and Sons Ltd Microbes
Book SynopsisAn accessible introduction to the world of microbesfrom basic microbe biology through industrial applications Microbes affect our lives in a variety of waysplaying an important role in our health, food, agriculture, and environment. While some microbes are beneficial, others are pathogenic or opportunistic. Microbes: Concepts and Applications describes basic microbe biology and identification and shows not only how they operate in the subfields of medicine, biotechnology, environmental science, bioengineering, agriculture, and food science, but how they can be harnessed as a resource. It provides readers with a solid grasp of etiologic agents, pathogenic processes, epidemiology, and the role of microbes as therapeutic agents. Placing a major emphasis on omics technology, the book covers recent developments in the arena of microbes and discusses their role in industry and agriculture, as well as in related fields such as immunology, cell biology, and moleTable of ContentsPREFACE xiii ACKNOWLEDGMENTS xv 1 HUMAN AND MICROBIAL WORLD 11.1 Prologue 11.2 Innovations in Microbiology for Human Welfare 11.3 The Microbial World 241.4 Future Challenges: Metagenomics 57 2 GENE TECHNOLOGY: APPLICATIONS AND TECHNIQUES 652.1 Prologue 652.2 Introduction to Gene Technology 652.3 Nucleic Acid Hybridization 752.4 DNA Sequencing 882.5 Polymerase Chain Reaction 992.6 Omics Technology and Microbes 1032.7 Bioinformatics in Microbial Technology 1242.8 Future Challenges: The Biochips 126 3 MEDICAL MICROBIOLOGY AND MOLECULAR DIAGNOSTICS 1513.1 Prologue 1513.2 Microbial Biology 1523.3 Infection and Immunity 1603.4 Bacterial Pathogens and Associated Diseases 1853.5 Viral Pathogens and Associated Diseases 2093.6 Prions 2273.7 Parasitic Infections 2283.8 Fungal Pathogen 2493.9 Microbial Diagnostics 2533.10 Future Challenges: Promises of Pharmacogenomics 265 4 IDENTIFICATION AND CLASSIFICATION OF MICROBES 2754.1 Prologue 2754.2 Principles of Taxonomy 2764.3 Using Phenotypic Characteristics to Identify Microbes 2814.4 Using Genotypic Character to Identify Microbes 2994.5 Characterizing Strain Differences 3064.6 Classification of Microbes on the Basis of Phenotypic Characteristics 3194.7 Classification of Microbes on the Basis of Genotypic Characters 3244.8 Future Challenges: Aptamers for Detection of Pathogens 333 5 DIVERSITY OF MICROORGANISMS 3395.1 Prologue 3395.2 Physiological Diversity of Microorganisms 3395.3 Thriving in Terrestrial Environment 3455.4 Aquatic Environment 3535.5 Animals as Habitat 3645.6 Archaea in Extreme Environments 3685.7 Biogeochemical Cycles 3735.8 Environmental Influence and Control of Microbial Growth 3775.9 Microorganisms and Organic Pollutants 3855.10 Microorganisms and Metal Pollutants 3965.11 Environmentally Transmitted Pathogens 4055.12 Microorganisms as Friends of Man 4535.13 Microbes as a Disastrous Enemy 4685.14 Future Challenges: Microbes in the Space 472 6 MICROBES IN AGRICULTURE 4816.1 Prologue 4816.2 The Soil Plant Microorganisms 4826.3 Root Microbial Interaction 5006.4 Pathogenic Microbes in Agriculture 5086.5 Microbes as a Tool of Genetic Engineering 5356.6 Future Challenges: Functional Genomics Approach for Improvement of Crops 557 7 MICROBES AS A TOOL FOR INDUSTRY AND RESEARCH 5677.1 Prologue 5677.2 Historical Development 5677.3 Clinical Diagnostics in a New Era 5787.4 Industrial Microorganisms and Product Formation 6157.5 Major Industrial Products for Health and Industry 6227.6 Food Diagnostics, Food Preservation, and Foodborne Microbial Diseases 6497.7 Future Challenges: Next Generation Diagnostics Industry 680References 681 INDEX 685
£181.40
John Wiley and Sons Ltd Dictionary of Developmental Biology and
Book SynopsisA newly revised edition of the standard reference for the field today updated with new terms, major discoveries, significant scientists, and illustrations Developmental biology is the study of the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels.Trade Review“Dictionary of Developmental Biology and Embryology is a "must-have" reference and resource for students in the field as well as college library collections; professional biologists will also find it convenient and useful to keep handy. Highly recommended.” (Midwest Book Review, 1 March 2013) “It would be best suited for undergraduates taking a developmental biology course or for new graduate students in the field. Summing Up: Recommended. Lower-division undergraduates through graduate students.” (Choice, 1 August 2012) Table of ContentsPreface vii A 1 B 17 C 30 D 51 E 62 F 75 G 82 H 92 I 107 J 114 K 115 L 118 M 123 N 141 O 149 P 155 Q 178 R 179 S 187 T 207 U 216 V 219 W 224 X 227 Y 228 Z 230 Reference 232 Color Plates
£56.95
Wiley Atlas of Human Anatomy
Book Synopsis
£66.56
John Wiley and Sons Ltd Visualizing Anatomy and Physiology
Book SynopsisTable of Contents1 Organization of the Human Body. 2 Introductory Chemistry. 3 Cells and Tissues. 4 The Integumentary System. 5 The Skeletal System. 6 The Muscular System. 7 The Nervous System. 8 Somatic Senses and Special Senses. 9 The Endocrine System. 10 The Cardiovascular System: Blood. 11 The Cardiovascular System: Heart, Blood Vessels, and Circulation. 12 The Lymphatic System and Immunity. 13 The Respiratory System. 14 The Digestive System, Nutrition, and Metabolism. 15 The Urinary System, Fluid, Electrolyte, and Acid-Base Balance. 16 The Reproductive Systems. Appendix A Periodic Table. Appendix B Measurements. Appendix C Answers to Self-Tests. Glossary. Line Art Credits. Photo Credits. Index.
£128.66
John Wiley and Sons Ltd Livestock Epigenetics
Book SynopsisLivestock Epigenetics reviews advances in the understanding of the molecular basis of epigenetic mechanisms in gene expression in livestock species. Epigenetics impact many economically important traits from growth and development to more efficient reproduction and breeding strategies.Table of ContentsContributors vii Preface xi 1. Epigenetics of Mammalian Gamete and Embryo Development 3Nelida Rodriguez-Osorio, Sule Dogan, and Erdogan Memili 2. Epigenetics of Cloned Preimplantation Embryos of Domestic Animals 27X. Cindy Tian and Sadie L. Marjani 3. Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide Technologies 43Ashley Driver, Wen Huang, and Hasan Khatib 4. Sheep as an Experimental Model for Human ART: Novel Insights on Phenotypic Alterations in ART-Derived Sheep Conceptuses 59Pasqualino Loi, Antonella D’Agostino, Marta Czernik, Federica Zacchini, Paola Toschi, Antonella Fidanza, and Grazyna Ptak 5. The DLK1-DIO3 Imprinted Gene Cluster and the Callipyge Phenotype in Sheep 73Christopher A. Bidwell, Ross L. Tellam, Jolena N. Waddell, Tony Vuocolo, Tracy S. Hadfield, and Noelle E. Cockett 6. Genomic Imprinting and Imprinted Gene Clusters in the Bovine Genome 89Ikhide G. Imumorin, Sunday O. Peters, and Marcos De Donato 7. Imprinting in Genome Analysis: Modeling Parent-of-Origin Effects in QTL Studies 113Suzanne Rowe, Stephen Bishop, and D. J. de Koning 8. Epigenetics and Animal Health 131Juan Luo, Ying Yu, and Jiuzhou Song 9. Epigenetics and microRNAs in Animal Health 147Fei Tian and Jiuzhou Song 10. Nutrients and Epigenetics in Bovine Cells 161Cong-jun Li, Robert W. Li, and Ted H. Elsasser Index 179
£190.90
John Wiley and Sons Ltd Feed Efficiency in the Beef Industry
Book SynopsisFeed efficiency is increasingly seen as an important factor in both the economic viability and environmental sustainability of cattle production. This book provides beef industry professionals and researchers with a thorough yet concise overview of feed efficiency research.Table of ContentsContributors ix Foreword xi Preface xiii Acknowledgments xv Introduction 1Rodney A. Hill Chapter 1 Input Factors Affecting Profitability: a Changing Paradigm and a Challenging Time 7Jason K. Ahola and Rodney A. Hill Chapter 2 Measuring Individual Feed Intake and Utilization in Growing Cattle 21D.H. (Denny) Crews, Jr. and Gordon E. Carstens Chapter 3 Producer Awareness and Perceptions about Feed Efficiency in Beef Cattle 29J.D. Wulfhorst, Stephanie Kane, Jason K. Ahola, John B. Hall, and Rodney A. Hill Chapter 4 Feed Efficiency in Different Management Systems: Cow-Calf and in the Feedyard 47Keela M. Retallick and Dan B. Faulkner Chapter 5 Lessons from the Australian Experience 61Robert M. Herd and Paul F. Arthur Chapter 6 Nutrition and Feed Efficiency of Beef Cattle 75Monty S. Kerley Chapter 7 Genetic Improvement of Feed Efficiency 93Paul F. Arthur and Robert M. Herd Chapter 8 Feed Efficiency and Animal Robustness 105Wendy M. Rauw Chapter 9 Interactions with Other Traits: Reproduction and Fertility 123John A. Basarab, Carolyn Fitzsimmons, C. Scott Whisnant, and Robert P. Wettemann Chapter 10 Feed Efficiency Interactions with Other Traits: Growth and Product Quality 145Rodney A. Hill and Jason K. Ahola Chapter 11 Estimating Feed Efficiency of Lactating Dairy Cattle Using Residual Feed Intake 159Erin E. Connor, Jana L. Hutchison, and H. Duane Norman Chapter 12 Muscle and Adipose Tissue: Potential Roles in Driving Variation in Feed Efficiency 175Cassie M. Welch, Marcus McGee, Theresa A. Kokta, and Rodney A. Hill Chapter 13 Epigenetics and Effects on the Neonate That May Impact Feed Efficiency 199Allison M. Meyer, Joel S. Caton, Bret W. Hess, Stephen P. Ford, and Lawrence P. Reynolds Chapter 14 Hormonal Regulation of Feed Efficiency 225Michael E. Davis, Macdonald P. Wick, and Martin G. Maquivar Chapter 15 Variation in Metabolism: Biological Efficiency of Energy Production and Utilization That Affects Feed Efficiency 251Walter G. Bottje and Gordon E. Carstens Chapter 16 Modeling Feed Efficiency 275Roberto Sainz Index 287
£135.80
John Wiley and Sons Ltd Translational Neuroscience
Book SynopsisTranslational research looks to take the latest innovations made in the laboratory setting to translate findings into effective and sustainable medical interventions and improved preventative measures.Trade Review“This is a useful reference for neuroscience program developers such as basic and clinical scientists, administrators of neuroscience centers, department chairs, and deans.” (Doody’s, 7 September 2012) Table of ContentsContributors xi Preface xiii Acknowledgments xv 1 A Brief History of Translational Neuroscience 1Edgar Garcia-Rill Some recent history 1 Funding translational research 3 Lack of funding 4 Making NIH funding more equitable and efficient 6 How much funding is needed? 7 Medical research funding in Europe 10 References 13 2 Mentoring in Translational Neuroscience 15Edgar Garcia-Rill T1 blocks 15 T2 blocks 20 References 27 3 Core Facilities for Translational Neuroscience 29Edgar Garcia-Rill Designing translational neuroscience core facilities 31 Preattentional measure—the P50 potential 33 Attentional measures—psychomotor vigilance 35 Frontal lobe blood flow measures 36 References 42 4 Translational Studies Using TMS 43Mark Mennemeier, Christine Sheffer, Abdallah Hayar, and Roger Buchanan Overview 43 Introduction 44 Development of a sham stimulation technique for humans 45 PET-guided TMS studies of tinnitus perception 46 TMS investigations of decision-making in tobacco addiction 50 TMS investigations in rodents 54 Conclusion 61 References 61 5 Translational Studies in Drug Abuse 67Veronica Bisagno, William E. Fantegrossi, and Francisco J. Urbano Background and significance 67 Behavioral Core Facility 70 Voltage-sensitive dye imaging 75 Intravenous drug self-administration 75 References 79 6 Electrophysiology in Translational Neuroscience 83Edgar Garcia-Rill In vivo and in vitro animal models 83 Modafinil 84 Patch clamp recordings 85 Gamma band activity 86 Population responses 88 Preconscious awareness 89 Magnetoencephalography, the Cadillac of human electrophysiology 91 References 94 7 Translational Research on Spinal Cord Injury 97Charlotte Yates and Kevin Garrison Electrophysiological approach: H-reflex frequency-dependent depression 98 Biomechanical approach: windup of the stretch reflex 100 Interventions: passive exercise 101 Interventions: pharmacology (L-Dopa, Modafinil) 105 Conclusions 106 References 106 8 Translational Research in Neonatology 109Richard Whit Hall Introduction 109 The need for neonatal research 110 The building blocks: basic research 110 Pups to babies and back again: T1 Research 111 No problem can be solved unless it is first identified 112 From the bedside to the community: T2 research 113 The role of comparative effectiveness research 116 Barriers and rewards in translational research in neonatology 118 Opportunities for translational research in neonatology 119 Conclusion 119 References 120 9 Telemedicine in Translational Neuroscience 123Amy Ballard and Richard Whit Hall History of telemedicine 124 Enabling access to care 125 Telemedicine Core Facility 126 Neonatal intensive care 129 Emergency departments 131 Conclusion 132 References 132 10 Implications for the Future 135Edgar Garcia-Rill Fragmented infrastructure 135 Incompatible databases 136 The benefits of translational research 138 The reshaping of basic science departments 139 References 142 Index 145
£77.85
John Wiley and Sons Ltd Glial Physiology and Pathophysiology
Book SynopsisThis comprehensive advanced text on the biology and pathology of glial cells--the most numerous cells in the brain and an emerging field in neuroscience--offers detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system.Table of ContentsPreface xvii About the Authors xxi Abbreviations xxv About the Companion Website xxxii 1 History of Neuroscience and the Dawn of Research in Neuroglia 1 1.1 The miraculous human brain: localising the brain functions 1 1.2 Cellular organisation of the brain 10 1.3 Mechanisms of communications in neural networks 14 1.4 The concept of neuroglia 27 1.5 Beginning of the modern era 47 1.6 Concluding remarks 49 References 49 2 General Overview of Signalling in the Nervous System 59 2.1 Intercellular signalling: wiring and volume modes of transmission 59 2.2 Cellular signalling: receptors 62 2.3 Intracellular signalling: second messengers 67 2.4 Calcium signalling 67 2.5 Concluding remarks 72 3 Neuroglia: Definition, Classification, Evolution, Numbers, Development 73 3.1 Definition of neuroglia as homeostatic cells of the nervous system 74 3.2 Classification 75 3.3 Evolution of neuroglia 76 3.4 Numbers: how many glial cells are in the brain? 93 3.5 Embryogenesis and development of neuroglia in mammals 96 3.6 Concluding remarks 99 References 100 4 Astroglia 105 4.1 Definition and heterogeneity 107 4.2 Morphology of the main types of astroglia 113 4.3 How to identify astrocytes in the nervous tissue 119 4.4 Astroglial syncytial networks 120 4.5 Physiology of astroglia 125 4.6 Functions of astroglia 175 4.7 Concluding remarks 231 References 231 5 Oligodendrocytes 245 5.1 Oligodendrocyte anatomy 247 5.2 Myelin structure and function 252 5.3 Physiology of oligodendrocytes 266 5.4 Oligodendrocyte development 283 5.5 Concluding remarks 299 References 299 6 NG2-glial Cells 321 6.1 Definition of NG2-glia 321 6.2 Structure of NG2-glia 324 6.3 Physiology of NG2-glia 327 6.4 Proliferation of NG2-glia and generation of oligodendrocytes 332 6.5 Relationship between NG2-glia and CNS pericytes 333 6.6 Evolution of NG2-glia 336 6.7 Concluding remarks 337 References 337 7 Microglia 343 7.1 Definition of microglia 344 7.2 Microglial origin and development 345 7.3 Morphology of microglia 345 7.4 General physiology of microglia 351 7.5 Microglial migration and motility 372 7.6 Physiological functions of microglia: role in synaptic transmission and plasticity 373 7.7 Microglia in ageing 375 7.8 Concluding remarks 375 References 376 8 Peripheral Glial Cells 381 8.1 Peripheral nervous system 382 8.2 Schwann cells 390 8.3 Satellite glial cells 407 8.4 Enteric glia 412 8.5 Olfactory ensheathing cells (OECs) 418 8.6 Concluding remarks 422 References 423 9 General Pathophysiology of Neuroglia 431 9.1 Neurological disorders as gliopathologies 431 9.2 Reactive astrogliosis 433 9.3 Wallerian degeneration 439 9.4 Excitotoxic vulnerability of oligodendrocytes: the death of white matter 442 9.5 Activation of microglia 444 9.6 Concluding remarks 449 References 450 10 Neuroglia in Neurological Diseases 453 10.1 Introduction 454 10.2 Genetic astrogliopathology: Alexander disease 456 10.3 Stroke and ischaemia 458 10.4 Migraine and spreading depression 467 10.5 CNS oedema 469 10.6 Metabolic disorders 471 10.7 Toxic encephalopathies 473 10.8 Neurodegenerative diseases 474 10.9 Leukodystrophies 487 10.10 Epilepsy 488 10.11 Psychiatric diseases 490 10.12 Autistic disorders 491 10.13 Neuropathic pain 492 10.14 Demyelinating diseases 494 10.15 Infectious diseases 496 10.16 Peripheral neuropathies 499 10.17 Gliomas 501 10.18 Concluding remarks 504 References 504 Author Index 513 Subject Index 517
£66.95
John Wiley and Sons Ltd Concise Encyclopaedia of Bioinformatics and
Book SynopsisConcise Encyclopaedia of Bioinformatics and Computational Biology, 2nd Edition is a fully revised and updated version of this acclaimed resource. The book provides definitions and often explanations of over 1000 words, phrases and concepts relating to this fast-moving and exciting field, offering a convenient, one-stop summary of the core knowledge in the area. This second edition is an invaluable resource for students, researchers and academics.Trade Review“This book is an invaluable resource for students, researchers, and academics. Summing Up: Highly recommended. Upper-division undergraduates through professionals/practitioners.” (Choice, 1 September 2014) Table of ContentsList of Contributors ix Preface xiii Entries A to Z 1 Author Index 791 Colour plate section facing p 210
£133.90
John Wiley & Sons Inc Reverse Genetics of RNA Viruses
Book SynopsisReverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applicatTable of ContentsList of contributors xi Acknowledgements xiii 1 Introduction 1 Anne Bridgen 1.1 Background 1 1.2 Reverse genetics for different classes of genome 2 1.3 Methodology 5 1.4 Difficulties in establishing a reverse genetics system 11 1.5 Recent developments 13 1.6 Are there any boundaries for conducting reverse genetics? 13 References 15 Part I Positive sense RNA viruses 25 2 Coronavirus reverse genetics 27 Maria Armesto, Kirsten Bentley, Erica Bickerton, Sarah Keep and Paul Britton 2.1 The Coronavirinae 27 2.2 Infectious bronchitis 28 2.3 Coronavirus genome organisation 29 2.4 The coronavirus replication cycle 30 2.5 Development of reverse genetics system for coronaviruses including IBV 33 2.6 Reverse genetics system for IBV 37 2.7 Reverse genetics systems for the modification of coronavirus genomes 40 2.8 Using coronavirus reverse genetics systems for gene delivery 49 Acknowledgements 51 References 51 3 Reverse genetic tools to study hepatitis C virus 64 Alexander Ploss 3.1 Introduction: hepatitis C 64 3.2 Hepatitis C virus 65 3.3 Construction of infectious clones for hepatitis C virus 68 3.4 Study of HCV RNA replication in cell culture systems 68 3.5 Use of HCV replicons to study viral replication 70 3.6 Utility of replicons for drug screening 71 3.7 Development of the infectious cell culture systems for HCV 71 3.8 Construction of intergenotypic viral chimeras 72 3.9 Non-JFH1 derived genomes 74 3.10 Cell lines that support HCV replication 74 3.11 Study of HCV in physiologically more relevant cell culture systems 75 3.12 Animal models for HCV infection 76 3.13 Reverse genetics of clinically relevant HCV genotypes in vivo 77 3.14 Conclusion 78 Acknowledgments 78 References 78 4 Calicivirus reverse genetics 91 Ian Goodfellow 4.1 Introduction 91 4.2 Feline calicivirus 93 4.3 Murine norovirus 97 4.4 Porcine enteric calicivirus 103 4.5 Rabbit haemorrhagic disease virus 104 4.6 Human norovirus 104 4.7 Conclusion 106 Acknowledgements 107 References 107 Part II Negative sense RNA viruses 113 5 Reverse genetics of rhabdoviruses 115 Alexander Ghanem and Karl-Klaus Conzelmann 5.1 Introduction: the Rhabdoviridae family 115 5.2 Rhabdovirus reverse genetics 121 5.3 Applications and examples 132 5.4 Conclusion 137 Acknowledgements 137 References 137 6 Modification of measles virus and application to pathogenesis studies 150 Linda J. Rennick and W. Paul Duprex 6.1 Introduction 150 6.2 Measles: the disease 150 6.3 Measles: the infectious agent 151 6.4 RNA synthesis: a tail of two processes 154 6.5 Transcription: starting, stopping, dropping off or starting again 154 6.6 From transcription to replication: the elusive switch 155 6.7 Getting in and getting out 157 6.8 Measles virus: reverse genetics 158 6.9 Future perspectives 181 Acknowledgements 182 References 182 7 Bunyavirus reverse genetics and applications to studying interactions with host cells 200 Richard M. Elliott 7.1 Introduction: the family Bunyaviridae 200 7.2 Bunyavirus replication 201 7.3 History of bunyavirus reverse genetics 203 7.4 Minigenome systems for bunyaviruses 205 7.5 Virus-like particle production 207 7.6 Rescue systems for bunyaviruses 208 7.7 Application of reverse genetics to study bunyavirus replication 208 7.8 Outlook 215 References 216 8 Using reverse genetics to improve influenza vaccines 224 Ruth A. Elderfield, Lorian C.S. Hartgroves and Wendy S. Barclay 8.1 Introduction 224 8.2 Influenza vaccines 227 8.3 The use of reverse genetics to generate recombinant influenza A, B and C viruses 229 8.4 Using reverse genetics technology for generation of pandemic virus vaccine 232 8.5 Other strategies for generating live attenuated vaccines based on viruses engineered by reverse genetics 235 8.6 Strategies to improve the safety or yield of influenza vaccines 238 8.7 Improvements to the PR8 high growth strain 239 8.8 Improving the immunogenicity by engineering recombinant viruses that express cytokine genes 240 8.9 Novel species-specific attenuation that takes advantage of microRNAs 240 8.10 Conclusion 241 References 241 Part III Double-stranded RNA viruses 251 9 Bluetongue virus reverse genetics 253 Mark Boyce 9.1 Introduction to Bluetongue virus 253 9.2 Bluetongue virus replication 254 9.3 Reverse genetics 260 9.4 Uses of reverse genetics in orbivirus research 271 9.5 Future perspectives 278 10 Genetic modification in mammalian orthoreoviruses 289 Sanne K. van den Hengel, Iris J.C. Dautzenberg, Diana J.M. van den Wollenberg, Peter A.E. Sillevis Smitt and Rob C. Hoeben 10.1 Introduction 289 10.2 Forward-genetics in orthoreoviruses 296 10.3 Reovirus/cell interactions 297 10.4 Reverse-genetics in orthoreoviruses 301 10.5 Reovirus as an oncolytic agent 306 10.6 Conclusion 308 References 309 Part IV Recent and future developments 319 11 Reverse genetics and quasispecies 321 Antonio V. Border´ýa and Marco Vignuzzi 11.1 Definition of quasispecies and evidence 321 11.2 Reverse genetics and RNA virus population heterogeneity: consensus is always a compromise 328 11.3 Examples of the use of the theory to disable or manipulate the quasispecies under controlled environments 333 11.4 Future prospects of virus population genetics and reverse genetics 339 11.5 Conclusion 341 References 342 12 Summary and perspectives 350 Anne Bridgen 12.1 Introduction 350 12.2 Analysis of the role of specific non-coding sequence motifs involved in replication, transcription, polyadenylation and packaging 351 12.3 Analysis of the roles of viral proteins 352 12.4 Analysis of virus–host interactions at a global level 353 12.5 Understanding the basis of pathogenicity 354 12.6 Real-time virus imaging in vitro and in vivo 355 12.7 Structure-function analysis of viruses and viral domains 356 12.8 Vaccine generation 357 12.9 Drug development 359 12.10 Gene delivery and knock-out in plant cells including virus-induced gene silencing (VIGS) 361 12.11 Gene delivery in arthropod and mammalian cells 362 12.12 Development of oncolytic virus and adaptation to this purpose 363 12.13 Personal highlights and future directions 364 References 366 Index 375
£117.95
John Wiley & Sons Inc Biomedical Sciences
Book SynopsisBiomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The bookincludes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The bookis visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the textlink the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).Trade Review“As an accompaniment to an undergraduate programme, this is an excellent text that manages to introduce all aspects of biomedical science to the reader.” (British Journal of Biomedical Science, 1 January 2013) “Overall, Biomedical Sciences: Essential Laboratory Medicine would make a fantastic starting textbook for biomedical students. It is accessible, clinically-focused and covers all major relevant topics. (Phenotype, 28 May 2012)Table of ContentsList of Contributors xi Preface xiii Chapter 1 Anatomy and physiology of major organ systems 1 Ray K. Iles, Iona Collins and Suzanne M. Docherty 1.1 The skeletal system 1 1.2 The digestive system 6 1.3 The cardiovascular system 11 1.4 The urinary system 17 1.5 Respiratory system 21 1.6 The nervous system 23 1.7 The endocrine system 31 Bibliography 33 Chapter 2 Pathophysiology 35 Suzanne M. Docherty 2.1 Pathophysiology: a definition 35 2.2 Introduction to epidemiology 35 2.3 Introduction to pharmacology 38 2.4 Gastroenterology 44 2.5 Liver, biliary tract and pancreatic disease 50 2.6 Rheumatology 56 2.7 Urinary tract disease 59 2.8 Cardiovascular disease 65 2.9 Respiratory disease 76 2.10 Endocrine disease 80 Bibliography 88 Chapter 3 Clinical cell biology and genetics 89 Ray K. Iles and Stephen A. Butler 3.1 The cell 89 3.2 Genetics 103 3.3 Human genetic disorders 116 3.4 Important techniques in molecular cell biology 136 Bibliography 138 Chapter 4 Cellular pathology 139 Christopher M. Stonard and Jennifer H. Stonard Part I: Principles of cellular pathology 139 4.1 Structure and function of normal cells, tissues and organs 139 4.2 Tissues and organs 140 4.3 Cellular responses to injury 141 4.4 Tissue responses to injury: acute inflammation 143 4.5 Tissue responses to injury: chronic inflammation 149 4.6 Healing and repair 151 4.7 Hyperplasia and hypertrophy 154 4.8 Atherosclerosis 155 4.9 Thrombosis and embolism 157 4.10 Ischaemia and infarction 159 4.11 Amyloid and amyloidosis 160 4.12 Infections of histological importance 162 4.13 Metaplasia, dysplasia and carcinoma in situ 165 4.14 Neoplasia 168 Part II: Clinical application and laboratory techniques 175 4.15 Sampling modalities 175 4.16 Fixation 178 4.17 Specimen dissection 180 4.18 Processing and embedding 182 4.19 Microtomy 184 4.20 Standard staining methods and procedures 186 4.21 Frozen section 190 4.22 Immunohistochemistry 191 4.23 Cytopathology 196 4.24 Electron microscopy 197 4.25 In situ hybridization 201 Bibliography 203 Chapter 5 Clinical chemistry 205 Ray K. Iles and Stephen A. Butler Introduction 205 Part I: Analytical methods 205 5.1 Sample collection 205 5.2 Analytical methods in clinical chemistry laboratories 210 5.3 Summary: common clinical tests for sample analytes 231 Part II: Clinical assessments 232 5.4 Urea and electrolytes (U and Es) 232 5.5 Metabolism and gastrointestinal markers 234 5.6 Renal function tests 236 5.7 Liver function tests 237 5.8 Heart disease and lipid disorder tests 238 5.9 Pancreatic function tests 240 5.10 Bone disease assessment 241 5.11 Endocrinological assessments 241 5.12 Pregnancy tests and pregnancy clinical chemistry 249 5.13 Therapeutic drug monitoring and toxicology 251 5.14 Clinical chemistry at the extremes of age 253 5.15 Cancer biomarkers 254 Bibliography 259 Chapter 6 Medical microbiology 261 Sarah J. Furrows and Catherine S. Fontinelle Introduction 261 6.1 Overview of microorganisms 261 6.2 Laboratory investigation of infection 265 6.3 Bacteria 277 6.4 Fungi 284 6.5 Parasitology --- protozoa and helminths 288 6.6 Viruses 290 6.7 Prions 297 6.8 Infections in the immunocompromised patient 298 6.9 Healthcare associated infections 299 6.10 Antimicrobial agents 302 6.11 Vaccines 307 6.12 Conclusion 309 Bibliography 309 Chapter 7 Clinical immunology 311 Ray K. Iles and Ivan M. Roitt Part I: The fundamentals of immunology 311 7.1 Overview of the immune system 311 7.2 Overview of the immune response 316 7.3 MHC genotyping, autoimmunity and susceptibility to disease 321 7.4 Physical age and immunocompetency 322 Part II: Laboratory investigations and immune assessments 323 7.5 Inflammation and chronic infection 323 7.6 Autoimmune diseases 324 7.7 Transplant rejection 325 7.8 Hypersensitivities 326 7.9 Immune deficiency 326 Bibliography 328 Chapter 8 Haematology and transfusion science 329 Suzanne M. Docherty 8.1 Introduction and components of blood 329 8.2 Routine laboratory blood tests 332 8.3 Haemopoiesis 336 8.4 Red blood cell structure, disorders and metabolism 337 8.5 Haemoglobin 342 8.6 Anaemia 353 8.7 Benign white blood cell disorders 359 8.8 Haemostasis 361 8.9 Coagulation disorders 366 8.10 Myeloproliferative disorders 371 8.11 Haematological malignancies 373 8.12 Complement 378 8.13 Blood transfusion 380 8.14 Blood products 390 8.15 Haemopoetic stem cell transplantation 393 Bibliography 395 Chapter 9 Professional practice and biomedical science 397 David Ricketts 9.1 What is a biomedical scientist? 397 9.2 The IBMS 397 9.3 Professional practice and the role of the HPC 398 9.4 Standards of proficiency --- biomedical scientists 399 9.5 Expectations of a health professional 400 9.6 Professional relationships 401 9.7 The skills required for the application of practice 401 9.8 Knowledge, understanding and skills 402 9.9 Standards of conduct, performance and ethics 403 9.10 CPD 403 9.11 Critical reflection 404 9.12 IBMS CPD scheme 404 9.13 The professional biomedical scientist as an agent for change in the wider healthcare setting 405 Appendix 407 Index 413
£128.95
John Wiley & Sons Inc Oncogenomics
Book SynopsisThis book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.Trade Review"…has many useful components for both basic scientists and clinicians involved in the application of genomics to an understanding of cancer diagnosis and therapy." (The Quarterly Review of Biology, March 2006) "…this book will be an appreciated resource for cancer researchers along with sophisticated oncologists and other health care providers." (American Journal of Medical Genetics, June 1, 2005) "...the first of its kind devoted to the genomics of cancer...very good reading...the essence of the book is to bring together scientists from various specialties and share the same language…” (New England Journal of Medicine, October 28, 2004) "...an excellent source of basic, up-to-date, readable material...in-depth explanations...already looking forward to the next edition..." (British Journal of Cancer Management, Vol 1(1), Summer 2004)Table of ContentsContributors. Preface. Second I: Introduction. 1. At the Precarious Cusp of Oncogenomics (Charles Brenner). Second II: Molecular Profiling in Cancer: DNA, RNA and Protein. 2. Genome-Wide Searches for Mutations in Human Cancer (Michael R. Stratton, P. Andrew Futreal, and Richard Wooster). 3. Molecular Cytogenetics: Increasing Resolution Using Array-Based CGH (Anne Kallioniemi). 4. SNPs and Functional Polymorphisms in Cancer (Penelope E. Bonnen and David L. Nelson). 5. Expression Profiling of Breast Cancer: From Molecular Portraits to Clinical Utility (Therese Sørlie, Anne-Lise Børresen-Dale, Per E. Lønning, Patrick O. Brown, and David Botstein). 6. Classifying Hereditary Cancers and Phenocopies of Hereditary Cancers Using Expression Arrays (Mary B. Daly, Alicia Parlanti, and David Duggan). 7. Linking Drugs and Genes: Pharmacogenomics, Pharmacoproteomics, Bioinformatics, and the NCI-60 (John N. Weinstein). 8. Tissue Microanalysis: Profiling Cancer Stages (Michael A. Tangrea and Michael R. Emmert-Buck). 9. Proteomic s in Bladder Cancer (Julio E. Celis, Irina Gromova, Fritz Rank and Pavel Gromov). Second III: Model Systems. 10. Chemical and Genetic Methods to Validate Targets in Nonmammalian Organisms (Tia M. Maiolatesi and Charles Brenner). 11. Mouse Models of Cancer (Debrah M. Thompson, Louise van der Weyden, Patrick J. Biggs, Yeun-Jun Chung and Allan Bradley). 12. Genome-Wide Modifier Screens: How the Genetics of Cancer Penetrance May Shape the Future of Prevention and Treatment (Linda D. Siracusa, Karen A. Silverman, Revati Koratkar, Marina Markova and Arthur M. Buchberg). Second IV: Molecularly Targeted Drugs. 13. Protein Kinases as Targets in Cancer Therapy: Validated and Emerging Approaches (Paul Nghiem, Yong-son Kim and Stuart L. Schreiber). 14. Ras Superfamily-Directed Compounds (George C. Prendergast). 15. Clinomics: Post-Genomic Cancer Care (Daniel D. Von Hoff, Haiyong Han, and David Bearss). Part V: Conclusion). 16. Oncogenomics and the NCI Director’s Vision for 2015 (Andrew C. von Eschenbach). Index.
£113.00
John Wiley & Sons Inc G ProteinCoupled ReceptorProtein Interactions
Book SynopsisThis exciting volume elucidates how GPCRs organize signal transduction and control intracellular activities. Chapters written by the recognized expert in each respective topic offer state-of-the-art updates on the principles and technology, as well as stepwise protocols for methods currently applied to the analysis of protein-receptor interactions.Trade Review"…a good starting point for the investigation of complex GPCR-protein interactions, and covers a lot of ground by introducing many different methodologies." (E-STREAMS, September 2005) " ... The Essentials of Trading will help those contemplating hands-on investing to determine whether they're cut out for the perilous and profitable world of global financial markets. If they proceed, Essentials will have armed them with the tricks for discipline and risk management." -- Rachel Koning Beals, SFO Magazine (July 2006)Table of ContentsForeword (Robert J. Lefkowitz). Series Preface (David R. Sibley). Preface (Susan R. George & Brian F. O'Dowd). Contributors. 1. Purification of the G Protein-Coupled Receptor Rhodopsin for Structural Studies (David Salom, Ning Li, Li Zhu, Izabela Sokal and Krzysztof Palczewski). 2. Cooperativity in Ligand Binding to Deduce Receptor/Receptor Interaction (Meritxell Vivo and Philip G. Strange). 3. Analysis of Receptor-Receptor Interaction Using Time-Resolved Fluorescence Resonance Energy Transfer (Douglas Ramsay and Graeme Milligan). 4. Real-Time Imaging of GPCR-Medicated Arresting Translocation as a Strategy to Evaluate Receptor-Protein Interactions (Robert H. Oakley, Larry S. Barak and Marc G. Caron). 5. Localization of G Protein Coupled Receptors and Interacting Proteins in Membrane Microdomains (K. Saidas Nair, Vijaya Narayanan and Vladlen Z. Slepak). 6. Identification of Peptide Ligand Binding Domains Within G Protein-Coupled Receptors Using Photoaffinity Labeling (Maoqing Dong and Laurence J. Miller). 7. Analysis in Real-Time of the Assembly and Disassembly of Soluble G Protein-Coupled Receptor-G Protein Complexes (Seam M. Biggs, Peter I. Simons, Anna Waller, Terry Founts, Tione Buranda, Eric R. Prossnitz and Larry A. Sklar). 8. Approaches to Studying Membrane Protein Oligomerization: Use of Cysteine Cross-Linking Strategies to Analyze Receptor-Receptor Interactions (Jonathan A. Javitch, Wen Guo and Marisa E. Ring). 9. Co-Immunoprecipitation as a Strategy to Evaluate Receptor-Receptor or Receptor-Protein Interactions (Randy A. Hall). 10. Use of MALDI-TOF and Mass Spectrometry in the Evaluation of Receptor-Protein Interactions (John R. Raymond, Henry Ayiku, Justin Turner, Andrew Gelasco and John M. Arthur). 11. Use of the Yeast Two-Hybrid System to Detect Receptor-Protein Interactions (Ridwan Lin, Nadine Kabbani, Alicia Binda, Victor Canfield and Robert Levenson). 12. GST Fusion Protein and Pull-down Strategies to Evaluate Receptor-Receptor or Receptor-Protein Interactions (Frank J.S. Lee and Fang Liu). 13. G-Protein-Coupled Fusion to Monitor Integral Membrane Protein-Protein Interactions (Henrik Dohlman and Kathleen Ehrhard). 14. Enzyme-Linked Immunosorbent Assays as Tools in Studying Interactions of G-Protein-Coupled Receptors (Torsten Schöneberg, Katrin Sangkuhl, Holger Römpler and Angela Schulz). 15. Electrophysiological Characterization of GPCR and Ligand-Gated Channel Crosstalk (Tak Pan Wong, Xian-Ming Yu and Yu Tian Wang). 16. BRET as a Strategy to Evaluate Receptor-Receptor or Receptor-Protein Interactions (Karen A. Eidne and Kevin D.G. Pfleger). Index.
£221.30
John Wiley & Sons Inc Perl Programming for Biologists
Book SynopsisWorking on the assumption that the reader has no formal training in programming, this book demonstrates how Perl is used to solve biological problems. Each chapter opens with a set of learning objectives, provides numerous review questions and self-study exercises, and concludes with a bulleted summary of key points.Trade Review"This well written book illustrates PERL with examples…Those with less or no programming skills should read this book before attempting the practice of bioinformatics ideas." (Journal of Statistical Computation & Simulation, January 2005) "…the book is useful to biologists who already use languages like C+ or Visual Basic and want to learn Perl." (Biomolecular Engineering, November 2004) “…written in a pleasant chatty style with obvious enthusiasm for the topic” (Robotica, Vol. 22, 2004) “...unique and I highly recommend it as a first book on programming for biology-oriented professionals interested in using perl...excellent for self-study...can also be a great resource as classroom material...” (Clinical Chemistry, Vol. 50, No. 2, 2004) "...not be surprised to see [it] finding a space on the bookshelves in many biological laboratories in the near future." (Briefings in Bioinformatics, Vol 5(1), March 2004)Table of ContentsPART I: THE BASICS. Introduction. Chapter 1. An Introduction to Perl. Chapter 2. Variables and Data Types. Chapter 3. Arrays and Hashes. Chapter 4. Control Structures. PART II: INTERMEDIATE PERL. Chapter 5. Subroutines. Chapter 6. String Manipulation. Chapter 7. Input and Output. Chapter 8. Perl Modules and Packages. PART III: ADVANCED PERL. Chapter 9. References. Chapter 10. Object-Oriented Programming. Chapter 11. Bioperl. Appendix A. Partial Perl Reference. Appendix B. Bioinformatics File Formats. Index.
£85.45
John Wiley & Sons Inc GeneEnvironment Interactions Fundamentals of
Book SynopsisThis book covers basic and applied concepts of ecogenetics. The book is organized into four sections. The first section covers fundamental aspects of ecogenetics. The second section discusses key genetic polymorphisms relevant for ecogenetics.Trade Review"…highly recommended for academic libraries that have undergraduate and graduate studies in genetics, toxicology, and pharmacology." (E-STREAMS, September 2007) "...a great accomplishment, and it can well serve as a primary, extensively-referenced text..." (American Journal of Medical Genetics, Part A, August 1, 2007) "...a must-have for all toxicology and pharmacology students as well as a great resource for researchers and physicians." (Environmental Health Perspectives, June 2006) "...a vital in-office reference for any scientific researcher dedicated to the study of genetics...invaluable to public health researchers who are look at how global threats live Avian Flu might spread to the general populous...an indispensable reference to all health science libraries." (The Electric Review, March/April 2006)Table of ContentsForeword. Acknowledgments. Contributors. PART I. Chapter 1. Introduction (Lucio G. Costa and David L. Eaton). Chapter 2. Ecogenetics: Historical Perspectives (Gilbert S. Omenn and Arno G. Motulsky). Chapter 3. Tools of Ecogenetics (Theo K. Bammler, Federico M. Farin, and Richard P. Beyer). Chapter 4. Epidemiologic Approaches (Harvey Checkoway, Parveen Bhatti, and Anneclaire De Roos). Chapter 5. Statistical Issues in Ecogenetic Studies (Stephanie A. Monks). PART II. Chapter 6. Overview of Section II (Lucio G. Costa and David L. Eaton). Chapter 7. Polymorphisms in Cytochrome P450 and Flavin-Containing Monooxygenase Genes (Catherine K.Yeung, Allan E. Rettie, and Kenneth E. Thummel) Chapter 8. Polymorphisms in Xenobiotic Conjugation (Helen E. Smith, David L. Eaton, and Theo K. Bammler). Chapter 9. Paraoxonase, Butyrylcholinesterase, and Epoxide Hydrolase (Lucio G. Costa, Toby B. Cole, Gary K. Geiss, and Clement E. Furlong). Chapter 10. DNA Repair Enzymes (Jon P. Anderson and Lawrence A. Loeb). Chapter 11. Receptors and Ion Channels (Lucio G. Costa). PART III. Chapter 12. Overview of Section III (Lucio G. Costa and David L. Eaton). Chapter 13. Lung Cancer (Valle Nazar-Stewart). Chapter 14. Gastrointestinal Cancers (Thomas L.Vaughan). Chapter 15. Neurodegenerative Diseases (Samir N. Kelada, Harvey Checkoway, and Lucio G. Costa). Chapter 16. Cardiovascular Disease (Melissa A.Austin and Stephen M. Schwartz). Chapter 17. Type 2 Diabetes (Karen L. Edwards). Chapter 18. Infectious Disease Ecogenetics (David R. Sherman). Chapter 19. Genetic Variation, Diet, and Disease Susceptibility (Johanna W. Lampe and John D. Potter). Chapter 20. Genetic Determinants of Addiction to Alcohol, Tobacco, and Drugs of Abuse (Andrew J. Saxon). PART IV. Chapter 21. Overview of Section IV (Lucio G. Costa and David L. Eaton). Chapter 22. Ethical Issues in Ecogenetics (Kelly Fryer-Edwards, Lindsay A. Hampson, Christopher R. Carlsten, and Wylie Burke). Chapter 23. Social and Psychological Aspects of Ecogenetics (Deborah Bowen, Shirley Beresford, and Brenda Diergaarde). Chapter 24. Legal Issues (Kate Battuello and Anna Mastroianni). Chapter 25. Risk Assessment and the Impact of Ecogenetics (Elaine M. Faustman and Gilbert S. Omenn). Bibliography. Index.
£160.50
John Wiley & Sons Inc Bacillus Thuringiensis Biology Ecology and Safety
Book SynopsisThe bacterium, Bacillus thuringiensis (B.t.), is used in products worldwide as a biological control agent for species of insect pest, either by crop spraying or genetic engineering of crop plants. This text provides information on the environmental, non-target and human safety of these products.Trade Review"The book can be recommended as a comprehensive and valuable source of information" (Journal of Plant Physiology, Vol 158/7, 2001) "This is a useful complement to the Bacillus thuringiensis literature that will find application in both teaching and research." (Microbiology Today, February 2002) "I recognise and salute the Herculean effort that was involved in producing a review of this scope and magnitude" (Biocontrol Science & Technology, No. 12 2002)Table of ContentsCharacterisation. Natural Occurrence and Role in the Environment. Production and Formulation. Toxicity to Insects. Effects on Non-target Microbes and Invertebrates. Effects on Vertebrates. Persistence and Activity in the Environment. Insect and Environmental Factors Affecting Toxicity. Transmission and Dispersal. Effects in Combination with Other Insecticidal Agents. Gene Transfer. Transgenic Use of Bt Toxin Genes. Resistance. Conclusions: Safety and Risks. References. Appendices. Index.
£278.30
John Wiley & Sons Inc Microbial Proteomics Functional Biology of Whole
Book SynopsisThis work provides an overview of microbial proteomics, highlighting practical deliverables that can be applied to work in eukaryotic proteomes. It shows how accomplishments in this field have contributed to our understanding of genomic and cellular function, as well as modes of therapeutic action, drug toxicity and biomolecular interactions.Trade Review"The authors have provided a thorough overview of what is still a relatively new field of study." (CHOICE, January 2007)Table of ContentsPREFACE. ACKNOWLEDGMENTS. CONTRIBUTORS. PART I: GENERAL PROTEOMICS OF MICROORGANISMS/MODEL ORGANISMS. 1. Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics (Valerie Wasinger). 2. Strategies for Measuring Dynamics: The Temporal Component of Proteomics (Robert J. Beynon and Julie M. Pratt). 3. Quest for Complete Proteome Coverage (C. David O’Connor, Ian N. Clarke, and Paul Skipp). 4. Proteome of Mycoplasma pneumoniae (Richard Herrmann and Thomas Ruppert). 5. Proteomics of Archaea (Ricardo Cavicchioli, Amber Goodchild, and Mark Raftery). PART II: PROTEOMICS AND CELL PHYSIOLOGY. 6. Elucidation of Mechanisms of Acid Stress in Listeria monocytogenes by Proteomic Analysis (Luu Phan-Thanh and Lothar Jänsch). 7. Oxidation of Bacterial Proteome in Response to Starvation (Thomas Nyström). 8. Tale of Two Metal Reducers: Comparative Proteome Analysis of Geobacter sulferreducens PCA and Shewanella oneidensis MR-1 (Carol S. Giometti). 9. AMT Tag Approach to Proteomic Characterization of Deinococcus radiodurans and Shewanella oneidensis (Mary S. Lipton, Margaret F. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic, Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K. Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic, and Richard D. Smith). PART III: PHYSIOLOGICAL PROTEOMICS OF INDUSTRIAL BACTERIA. 10. Proteomics of Corynebacterium glutamicum: Essential Industrial Bacterium (Andreas Burkovski). 11. Proteomics of Lactococcus lactis: Phenotypes for a Domestic Bacterium (Mogens Kilstrup). 12. Proteomic Survey through Secretome of Bacillus subtilis (Haike Antelmann, Jan Maarten van Dijl, Sierd Bron, and Michael Hecker). PART IV: PROTEOMICS OF PATHOGENIC MICROORGANISMS. 13. Analyzing Bacterial Pathogenesis at Level of Proteome (Phillip Cash). 14. Unraveling Edwardsiella tarda Pathogenesis Using the Proteomics Approach (P. S. Srinivasa Rao, Yuen Peng Tan, Jun Zheng, and Ka Yin Leung). 15. Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating Mycobacterium tuberculosis from Multiple Fronts (Michael Strong and Celia W. Goulding). 16. Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi (Catherine R. Bruce, Pieter van West, and Laura J. Grenville-Briggs). 17. Candida albicans Biology and Pathogenicity: Insights from Proteomics (Aida Pitarch, Ce´sar Nombela, and Concha Gil). 18. Contributions of Proteomics to Diagnosis, Treatment, and Prevention of Candidiasis (Aida Pitarch, Ce´sar Nombela, and Concha Gil). 19. Identification of Protein Candidates for Developing Bacterial Ghost Vaccines against Brucella (Vito G. Delvecchio, Tim Alefantis, Rodolfo A. Ugalde, Diego Comerci, Maria Ines Marchesini, Akbar Khan, Werner Lubitz, and Cesar V. Mujer). 20. Genomics and Proteomics in Reverse Vaccines (Guido Grandi). PART V: PROTEOME DATABASES, BIOINFORMATICS, AND BIOCHEMICAL MODELING. 21. Databases and Resources for in silico Proteome Analysis (Manuela Pruess, Paul Kersey, Tamara Kulikova, and Rolf Apweiler). 22. Interspecies and Intraspecies Comparison of Microbial Proteins: Learning about Gene Ancestry, Protein Function, and Species Life Style (Bernard Labedan and Olivier Lespinet). 23. Cellular Kinetic Modeling of the Microbial Metabolism (Igor I. Goryanin, Galina V. Lebedeva, Ekaterina A. Mogilevskaya, Eugeniy A. Metelkin, and Oleg V. Demin). INDEX.
£179.50
John Wiley and Sons Ltd Cancer Epigenetics
Book SynopsisCancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.Trade Review“In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.” (ChemMedChem, 1 July 2013)Table of ContentsContributors. Preface. SECTION I: EPIGENETICS AND CELL CYCLE. 1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso). SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION. 2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano). 3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn). 4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli). SECTION III: EPIGENETICS AND GENE TRANSCRIPTION. 5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini-Kerth). 6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano). SECTION IV: EPIGENETICS AND CANCER. 7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell). 8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa). 9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota). 10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio). SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY. 11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano). 12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr). 13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano). 14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio). Index.
£135.80
John Wiley & Sons Inc Biomacromolecules
Book SynopsisThis book is the first to offer an integrated, comprehensive overview of the structure and function of biomacromolecules together with a summary of the latest advances from bioinformatics and functional genomics.Trade Review"[The book] covers, in 18 chapters, most of what one would ever want to know about macromolecules' structure and functions." (Biotechnology Journal, June 2008)Table of ContentsPreface. Abbreviations in Repetitive Use. CHAPTER 1. INTRODUCTION. 1.1 Prelude. 1.2 Covalent Bonds. 1.3 Noncovalent Interactions. 1.4 Isomerism: Configuration versus Conformation. 1.5 Trilogy. 1.6 References. CHAPTER 2. MONOMER CONSTITUENTS OF BIOMACROMOLECULES. 2.1 Nucleotides: Constituents of Nucleic Acids. 2.2 á-Amino Acids: Constituents of Proteins. 2.3 Monosaccharides: Constituents of Glycans. 2.4 Addendum. 2.5 References. CHAPTER 3. PURIFICATION AND CHARACTERIZATION. 3.1 Purification: Overview. 3.2 Purification: Chromatography. 3.3 Purification: Electrophoresis. 3.4 Characterization: General. 3.6 References. CHAPTER 4. BIOMACROMOLECULAR STRUCTURE: NUCLEIC ACIDS. 4.1 Structural Organization. 4.2 Sequence Analysis of Nucleic Acids. 4.3 Secondary Structure and Structure Polymorphism of DNA. 4.4 Supercoiling and Tertiary Structure of DNA. 4.5 Classification and Structures of RNA. 4.6 RNA Folds and Structure Motifs. 4.7 Energetics of Nucleic Acid Structure. 4.8 Nucleic Acid Application. 4.9 References. CHAPTER 5. BIOMACROMOLECULAR STRUCTURE: PROTEINS. 5.1 Architecture of Protein Molecules. 5.2 Primary Structure of Proteins: Chemical and Enzymatic Sequence Analysis. 5.3 Primary Structure of Proteins: Sequence Analysis by Tandem Mass Spectrometry. 5.4 Conformational Map. 5.5 Secondary Structures and Motifs of Proteins. 5.6 Domains and Tertiary Structures of Proteins. 5.7 Classification of Protein Structures. 5.8 Quaternary (Subunit) Structures of Proteins. 5.9 Quinternary Structure Exemplified: Nucleoproteins. 5.10 Conformational Energetics. 5.11 References. CHAPTER 6. BIOMACROMOLECULAR STRUCTURE: POLYSACCHARIDES. 6.1 Propagation of Polysaccharide Chains. 6.2 Sequence Analysis of Polysaccharides: Primary Structure. 6.3 Conformation: Secondary and Tertiary Structures of Polysaccharide Chains. 6.4 Conformation: Description of Some Polysaccharide Structures. 6.5 Glycobiology: Study of Glycoprotein- Associated Glycans. 6.6 Neoglycoproteins. 6.7 Organizational Levels of Biomacromolecular Structures. 6.8 References. CHAPTER 7. STUDIES OF BIOMACROMOLECULAR STRUCTURES: SPECTROSCOPIC ANALYSIS OF CONFORMATION. 7.1 Biochemical Spectroscopy: Overview. 7.2 Ultraviolet and Visible Absorption Spectroscopy. 7.3 Fluorescence Spectroscopy. 7.4 Infrared Spectroscopy. 7.5 Nuclear Magnetic Resonance Spectroscopy. 7.6 Optical Rotatory Dispersion and Circular Dichroism Spectroscopy. 7.7 X-ray Diffraction Spectroscopy. 7.8 References. CHAPTER 8. STUDIES OF BIOMACROMOLECULAR STRUCTURES: CHEMICAL SYNTHESIS. 8.1 Rationale. 8.2 Synthetic Strategy: Conventional Approach. 8.3 Synthetic Strategy: Solid Phase Approach. 8.4 Practice of Solid Phase Synthesis and Its Application. 8.5 Combinatorial Synthesis. 8.6 Biochemical Polypeptide Chain Ligation. 8.7 References. CHAPTER 9. STUDIES OF BIOMACROMOLECULAR STRUCTURES: COMPUTATION AND MODELING. 9.1 Potential Energy and Molecular Thermodynamics. 9.2 Molecular Modeling: Molecular Mechanical Approach. 9.3 Statistical Thermodynamics. 9.4 Structural Transition: Examples. 9.5 Structure Prediction from Sequence by Statistical Methods. 9.6 Molecular Docking: Prediction of Biomacromolecular Binding. 9.7 References. CHAPTER 10. BIOMACROMOLECULAR INTERACTION. 10.1 Biomacromolecules in Solution. 10.2 Multiple Equilibria. 10.3 Allosterism and Cooperativity. 10.4 Specificity and Diversity of Antibody- Antigen Interactions. 10.5 Complementarity in Nucleic Acid Interactions. 10.6 Molecular Recognition in Carbohydrate- Lectin Interaction. 10.7 References. CHAPTER 11. BIOMACROMOLECULAR CATALYSIS. 11.1 Biocatalyst: Definition and Classification. 11.2 Characteristics of Enzymes. 11.3 Enzyme Kinetics. 11.4 Enzyme Mechanisms. 11.5 Enzyme Regulation. 11.6 Abzyme. 11.7 Ribozyme. 11.8 References. CHAPTER 12. SIGNAL TRANSDUCTION AND BIODEGRADATION. 12.1 Chemical Transduction: Metabolism. 12.2 Elements of Signal Transduction. 12.3 Effector Enzymes and Signal Transduction. 12.4 Topics on Signal Transduction. 12.5 Apoptosis. 12.6 Hydrolysis versus Phosphorolysis of Glycans. 12.7 Nucleolysis of Nucleic Acids. 12.8 Proteolysis and Protein Degradation. 12.9 References. CHAPTER 13. BIOSYNTHESIS AND GENETIC TRANSMISSION. 13.1 Saccharide Biosynthesis and Glycobiology. 13.2 Genetic Information and Transmission. 13.3 DNA Replication and Repair. 13.4 Biosynthesis and Transcription of RNA. 13.5 Translation and Protein Biosynthesis. 13.6 Folding of Biomacromolecules. 13.7 Bioengineering of Biomacromolecules. 13.8 References. CHAPTER 14. BIOMACROMOLECULAR INFORMATICS. 14.1 Overview. 14.2 Biosequences. 14.3 Microarray: General Description. 14.4 Computer Technology. 14.5 Informatics. 14.6 Gene Ontology. 14.7 References. CHAPTER 15. GENOMICS. 15.1 Genome: Features and Organization. 15.2 Genome Informatics: Databases and Web Servers. 15.3 Approaches to Gene Identification. 15.4 Gene Expression. 15.5 Genome Project. 15.6 References. CHAPTER 16. PROTEOMICS. 16.1 Proteome: Features and Properties. 16.2 Proteome Informatics: Sequence Databases and Servers. 16.3 Proteome Informatics: Structure Databases and Servers. 16.4 Proteome Informatics: Proteomic Servers. 16.5 Protein Structure Analysis Using Bioinformatics. 16.6 Investigation of Proteome Expression and Function. 16.7 Metabolome. 16.8 References. CHAPTER 17. GLYCOMICS. 17.1 Features of Glycomics. 17.2 Glycomic Databases and Servers. 17.3 Glycomics: Genetic Approaches. 17.4 Glycomics: Proteoglycomic Approaches. 17.5 Glycomics: Chemoglycomic Approaches. 17.6 References. CHAPTER 18. BIOMACROMOLECULAR EVOLUTION. 18.1 Variation in Biomacromolecular Sequences. 18.2 Element of Molecular Phylogeny. 18.3 Phylogenetic Analysis of Biosequences. 18.4 Application of Sequence Analyses in Phylogenetic Inference. 18.5 Evolution of Biosequences. 18.6 Evolution of Protein Structure and Function. 18.7 References. INDEX.
£160.50
John Wiley & Sons Inc Cancer Diagnostics with DNA Microarrays
Book SynopsisAuthored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers.Trade Review"…a ground-breaking addition…the best manual presently available on the use of DNA Microarrays in frontline cancer research." (Electric Review, February/March 2007)Table of ContentsPreface. Acnowldegments. 1. Introduction to DNA Microarray Technology. 2. Image Analysis. 3. Basic Data Analysis. 4. Visualization by Reduction of Dimensionality. 5. Cluster Analysis. 6. Molecular Classifiers for Cancer. 7. Survival Analysis. 8. Meta-Analysis. 9. The Design of Probes. 10. Software Issues and Data Formats. 11. Breast Cancer. 12. Leukemia. 13. Lymphoma. 14. Lung Cancer. 15. Bladder Cancer. 16. Colon Cancer. 17. Ovarian Cancer. 18. Prostate Cancer. 19. Melanoma. 20. Brain Tumors. 21. Organ or Tissue Specific Classification. 22. Sample Collection and Stability. References. Index.
£169.05
John Wiley & Sons Inc Structure Function and Modulation of Neuronal
Book SynopsisThis book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.Trade Review"This volume provides a very straightforward overview of complex pharmaceutical industry processes and will certainly be beneficial to readers with diverse backgrounds; particularly for those who are not specialists in protein manufacturing, but have a need to understand the entire manufacturing and commercialization process." (The Quarterly Review of Biology, June 2010)Table of ContentsPreface. Contributors. PART 1 NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTIONS. 1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and David J. Triggle). 2 Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch). 3 Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G. Waxman). 4 The Role of Ion Channels in the Etiology and Development of Gliomas (Amy K. Weaver and Harald Sontheimer). 5 Shaker Family Kv1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher and James S. Trimmer). 6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas). 7 Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and Leonard K. Kaczmarek). PART 2 MODULATORY MECHANISMS AND INFLUENCES ON NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION. 8 Alternative Splicing of Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis, and Jesica Raingo). 9 Effect of Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and Gabriel G. Haddad). 10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad Shahidullah, and Irwin B. Levitan). 11 Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and Nikita Gamper). 12 BK Channels: Regulation of Expression and Physiological Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M. Li, E. Stefani, and L. Toro). 13 Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (KeWei Wang and Jijie Chai). PART 3 DRUG DISCOVERY TARGETS AND TECHNOLOGY. 14 Sodium Channel Blockers for the Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan). 15 Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (Steven I. Dworetzky and Valentin K. Gribkoff). 16 Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E. Starrett Jr.). 17 High-Throughput Screening Technologies in Ion Channel Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark Treherne). Index.
£145.30
Cengage Learning, Inc Laboratory Manual for General Biology
Book Synopsis
£164.16
Mariner Books Play on
Book Synopsis
£21.60
Random House Publishing Group Becoming Earth
Book SynopsisA vivid account of a major shift in how we understand Earth, from an exceptionally talented new voice. Earth is not simply an inanimate planet on which life evolved, but rather a planet that came to life.“Glorious . . . full of achingly beautiful passages, mind-bending conceptual twists, and wonderful characters. Jabr reveals how Earth has been profoundly, miraculously shaped by life.”—Ed Yong, Pulitzer Prize winner and bestselling author of An Immense WorldA SMITHSONIAN AND CHICAGO PUBLIC LIBRARY BEST BOOK OF THE YEAROne of humanity’s oldest beliefs is that our world is alive. Though once ridiculed by some scientists, the idea of Earth as a vast interconnected living system has gained acceptance in recent decades. We, and all living things, are more than inhabitants of Earth—we are Earth, an outgrowth of its structure and an engine of its evolution. Life and its environment have coevolved for bill
£18.99
Penguin Young Readers Cómo funciona la biología How Biology Works
£21.60
John Wiley and Sons Ltd PaleoBase
Book SynopsisPaleoBase represents a unique combination of up-to-date systematic information on an extensive collection of fossil genera, state-of-the-art color digital photographs of representative specimens from The Natural History Museum s unrivalled paleontological collections, and modern relational database technology.Trade ReviewThis software is an excellent instructional resource for teaching in both small and large palaeontology classes Bruce Lieberman in Palaios Vol 17 An invaluable tool for any university that teaches undergraduate level palaeontology .....students will love it Rod Taylor in Geol Mag 138 Is this the future of paleontological publishing? We can only hope. Fossil News march 2001Table of ContentsCnidaria, Echinoderms, Sponges, 'Other'
£80.87
Penguin Putnam Inc Spying on Whales
Book Synopsis“A palaeontological howdunnit…[Spying on Whales] captures the excitement of…seeking answers to deep questions in cetacean science.” —Nature Called “the best of science writing” (Edward O. Wilson) and named a best book by Popular Science, a dive into the secret lives of whales, from their four-legged past to their perilous present.Whales are among the largest, most intelligent, deepest diving species to have ever lived on our planet. They evolved from land-roaming, dog-sized creatures into animals that move like fish, breathe like us, can grow to 300,000 pounds, live 200 years and travel entire ocean basins. Whales fill us with terror, awe, and affection--yet there is still so much we don''t know about them. Why did it take whales over 50 million years to evolve to such big sizes, and how do they eat enough to stay that big? How did their ancestors return from land to the sea--and what can
£15.30
DK The Biology Book Big Ideas Simply Explained
Book Synopsis
£25.19
Johns Hopkins University Press The Biolab Book TwentySix Laboratory Exercises
Book SynopsisThe author's enthusiasm, imagination, and talent shine through on every page, setting The Biolab Book far above conventional lab manuals.Table of ContentsPrefaceChapter 1. Introduction to DissectionChapter 2. Organs and Systems in the Pig: OneChapter 3. Organs and Systems in the Pig: TwoChapter 4. The MicroscopeChapter 5. The ProtistsChapter 6. On Being a Metazoan: Cnidaria and PoriferaChapter 7. The Worms That Got Organized: Platyhelminths and AschelminthsChapter 8. The Modular ApproachChapter 9. The Armored Ones: Arthropods OneChapter 10. The First to Fly: Arthropods TwoChapter 11. Happy as a Clam: The MollusksChapter 12. Strange Cousins: The EchinodermsChapter 13. The ProducersChapter 14. The TerranautsChapter 15. The Ubiquitous Ones: ProkaryotesChapter 16. The Tools of the TradeChapter 17. The Cell's AlchemistsChapter 18. The Master MoleculeChapter 19. ChloroplastsChapter 20. The Cell SurgaceChapter 21. MitochondriaChapter 22. Muscle ContractionChapter 23. Dissecting the CellChapter 24. The Dance of the ChromosomesChapter 25. Shuffling GenesChapter 26. Genes in Human PopulationsChapter 27. Getting it Together: Fertilization and DevelopmentChapter 28. SymbiosisChapter 29. Perception and BehaviorNotes for Instructors
£27.26
Johns Hopkins University Press Common Plants of the MidAtlantic Coast A Field
Book SynopsisAn easy- to-use key helps readers identify plants in the field according to physical features.Table of ContentsPreface AcknowledgmentsIntroduction A Key To Common Plants Of The Mid-Atlantic CoastPart I: Plants Of The Beach, Dunes, And Maritime ForestPart II: Plants Of Salt And Brackish MarshesPart III: Plants Of Freshwater Wetlands, Tidal And Nontidal (Including Forested Wetlands)Appendix A: National Seashores And Wildlife Refuges Along The Mid-Atlantic CoastAppendix B: Coastal State Parks And Wildlife Areas Along The Mid-Atlantic CoastGlossaryBibliographyIndex
£31.70
Johns Hopkins University Press Patterns of Distribution of Amphibians
Book SynopsisSweet, University of California, Santa Barbara; Michael J. Tyler, University of Adelaide, Australia; Zhao Er-Mi, Chengdu Institute of Biology, Peoples Republic of ChinaTrade ReviewAnyone with an interest in the distribution and/or abundance of amphibians will find something of value in this remarkable collection of essays. Copeia There can be no doubt that Patterns of Distribution of Amphibians is destined to become the standard reference on amphibian zoogeography. It is an impressive book containing a breathtaking wealth of detail, while at the same time encompassing an extraordinarily broad subject area. Herpetological Review Patterns of Distribution of Amphibians provides a gateway to the pertinent literature on amphibian distribution for each geographic region of the globe. It should be on the shelves in the herpetology or biogeography section of any academic or research library. Ecoscience This book is an instant classic reference, rich in data and comparison and contrast, a tribute to the industry of all its authors, but especially of its editor who has been a ever-growing force in amphibian systematics and zoogeography over four decades. Canadian Field-Naturalist 2003Table of ContentsPreface Chapter 1. Global Distribution of Amphibians: Patterns, Conservation, and Future ChallengesChapter 2. Distribution Patters of Amphibians in the Nearctic Region of North AmericaChapter 3. Distribution Patterns of Amphibians in Middle AmericaChapter 4. Distribution Patterns of Amphibians in the West Indies Chapter 5. Distribution Patterns of Amphibians in South AmericaChapter 6. Distribution of Amphibians in North Africa, Europe, Western Asia, and the Former Soviet UnionChapter 7. Distribution Patterns of Amphibians in Temperate Eastern AsiaChapter 8. Distribution of Amphibians in Southern Asia and Adjacent IslandsChapter 9. Distribution of Amphibians in Sub-Saharan Africa, Madagascar, and SeychellesChapter 10. Distribution Patterns of Amphibians in the Australo-Papuan RegionIndex
£83.00
Johns Hopkins University Press Dinosaurs of the Air The Evolution and Loss of
Book SynopsisFull of rich detail for the specialist but accessible to the intelligent lay reader, the book includes the author's own stunning illustrations and a technical appendix which provides information, for example, on body mass/wing dimension relationships and avian/dinosaurian metabolics.Trade ReviewPaul has succeeded in producing a beautiful book that will be an invaluable reference for those interested in avian origins for many years to come. -- Graham K. Taylor Ibis If you want to dig seriously into one of today's most fascinating evolutionary debates, and aren't afraid of anatomy, you'll delight in Dinosaurs of the Air. New Scientist 2002Table of ContentsContents: Preface PART I : Getting Started Chapter 1: A History Chapter 2: The Science of Bird Origins PART II: Skeletons, Bones and Other Remains of the Mesozoic Chapter 3: Skulls Chapter 4: Skeletons Chapter 5: Feathers and Other Fluff PART III: Flight: How and Why it Evolves, Why it is Lost, and How to Tell When Chapter 6: The Beginnings of Flight: From the Ground Up, or the Trees Down? Chapter 7: The Early Evolution of Flight Chapter 8: The Loss of Flight PART IV: The Archaeopteryx problem Chapter 9: Lifestyle for the Urvogel PART V: Who Is Related to Whom, and Why? Chapter 10: Looking for the True Bird Ancestor Chapter 11: Were Some Dinosaurs Neoflightless Birds? Chapter 12: A Look at the Phylogenetics of Predatory Dinosaurs PART VI: A Modest Scenario Chapter 13: The Mesozoic Chapter 14: The Great Extinction Chapter 15: The Cenozoic Appendix Bibliography Index
£65.34
Johns Hopkins University Press Wild Mammals of North America
Book SynopsisRevised to reflect new biological research and approaches to wildlife conservation amdn management, the second edition of this text continues to provide comprehensive data on the distribution, physiology, ecology, behaviour, commercial value and viability of non-game and game species.Trade ReviewProvides comprehensive data on the distribution, physiology, ecology, behavior and commercial value of both game and non-game species of terrestrial mammals... This volume is an essential for any professional in the areas of wildlife management or biology, and of great value to anyone interested in the life histories of North American mammals. Northeastern Naturalist 2004 Whether your interest in wildlife is as a wildlife manager, hunter or nature lover, a new book offers information on every mammal found in North America. Wild Mammals of North America, Biology, Management, and Conservation contains illustrations and detailed information on 57 mammalian species, with contributions from 100 leading authorities. Progressive Farmer 2004 I am very excited to now review a classic work in the field of North American Mammals. The goal of this book is to provide a wide ranging audience including professional biologists and interested conservationists review chapters dealing with mammals of that usually require some form of management... This new volume contains a total of 1000+ pages of text, 55 chapters, and over 100 contributors having been involved in writing the chapters. The authors all have direct experience with the animals they are writing about and this makes their work particularly valuable... This should be mandatory reading for anyone contemplating research on one of the species covered within this book... For AZA institutions heavily involved in North American species this book comes recommended. Library News for Zoos and Aquariums 2005 Anyone needing information on the life history and management of North American mammals will find this work a comprehensive and useful resource. Choice 2004 An excellent, encyclopedic review of the biology of North American mammals. -- Alecander Hristov Dairy Herd Network 2011Table of ContentsPreface and AcknowledgmentsIntroduction: A Twenty-Year RetrospectivePart I: Opossum, Moles, Bats, and ArmadilloChapter 1. Opossum Chapter 2. MolesChapter 3. BatsChapter 4. ArmadilloPart II: Rabbits and HaresChapter 5. Eastern CottontailChapter 6. Black0tailed JackrabbitChapter 7. Snowshoe Hare and Other HaresPart III: RodentsChapter 8. Mountain BeaverChapter 9. MarmotsChapter 10. Ground SquirrelsChapter 11. Black-tailed Prairie DogChapter 12. Fox and Gray SquirrelsChapter 13. Pine SquirrelsChapter 14. Pocket GophersChapter 15. BeaverChapter 16. MuskratsChapter 17. VolesChapter 18. PorcupineChapter 19. Eastern WoodratPart IV: Toothed Whales and Baleen WhalesChapter 20. Bottlenose Dolphin, Harbor Porpoise, Sperm Whale and Other Toothed CetaceansChapter 21. Baleen Whales: Right Whales and AlliesSection V: CarnivoresChapter 22. CoyoteChapter 23. Gray WolfChapter 24. FoxesChapter 25. Black BearChapter 26. Grizzly BearChapter 27. Polar BearChapter 28. RaccoonChapter 29. Fisher and MartenChapter 30. Weasels and Black-footed FerretChapter 31. MinkChapter 32. WolverineChapter 33. BadgerChapter 34. SkunksChapter 35. River OtterChapter 36. Sea OtterChapter 37. Mountain LionChapter 38. Bobcat and LynxSection VI: Seals and ManateeChapter 39. SealsChapter 40. West Indian ManateeSection VII: Hoofed MammalsChapter 41. Collared PeccaryChapter 42. WapitiChapter 43. Mule DeerChapter 44. White-tailed DeerChapter 45. MooseChapter 46. CaribouChapter 47. PronghornChapter 48. BisonChapter 49. Mountain GoatChapter 50. MuskoxChapter 51. Mountain SheepPart VIII: Introduced MammalsChapter 52. NutriaChapter 53. Wild HorseChapter 54. Feral HogChapter 55. Nonnative Large Mammals in North AmericaAppendix 1Appendix 2GlossaryIndex
£165.78
Johns Hopkins University Press Medicine by Design The Practice and Promise of
Book SynopsisThrough the stories of patients whose lives have been saved and improved by biomedical devices, Montaigne reveals the marriage of medicine and engineering to be one of society's greatest advances.Trade ReviewMontaigne writes engagingly... the book is a wonderful introduction to the field of biomedical engineering. Biofeedback Featuring some of the most recognized names in bioengineering as well as up-and-comers... this is the fascinating story of a discipline only dreamed of by Mary Shelley. Booklist 2006 College-level collections-and many a public library-will find it engrossing. Midwest Book Review 2006 The writing is this book's strength because it makes technical developments accessible to the nonspecialist. Doody's Review Service 2006 The book is well written and... it is easy to follow all the stories. -- George Demiris IEEE Engineering in Medicine & Biology 2007Table of ContentsAcknowledgmentsPrologue1. The Rise of a New Field2. The New Generation3. Beyond the Artificial Heart4. The Pump and Its Pipes5. To Breathe Again6. The Wires7. Moving into the Brain8. The da Vinci9. The Virtual Surgeon10. Bones11. The Pictures12. Seeing the Unseen13. The Business14. Weng's Wars15. Tissues16. Body Builders17. The Road AheadIndex
£34.91
Johns Hopkins University Press Owls of the United States and Canada A Complete
Book SynopsisFrom the great horned to the tiny elf owl, this amazing volume captures the beauty and mystery of these charismatic birds of prey.Trade ReviewBeautiful, readable, and affordable. So if you plan to give it as a give, I suggest you buy a copy for yourself as well. -- Whit Gibbons Tuscaloosa News 2007 This is a gorgeous book from celebrated natural history writer and wildlife photographer Wayne Lynch. Library Journal 2007 This is, in short, far and away the best owl book this reviewer has seen designed especially for general audiences. The writing is clear, concise, scientifically accurate, and totally readable. Choice 2008 This is a must have book for anyone interested in owls. Birdingnet.com 2008 This beautifully illustrated book contains a wealth of fascinating information... Will be much appreciated by birders, naturalists, and anyone with an interest in owls. -- C. R. Southeastern Naturalist 2008 This work is a labor of love. The author has done an admirable job. Quarterly Review of Biology 2008 Thoughtfully organized... it is an outstanding reference for this remarkable family of birds. Wildlife Activist 2008 I have more than a dozen owl books... but probably none is so attractive and accessibly informative as this one. -- Paul A. Johnsgard Great Plains Research 2009 Overall this book is a pleasure to read whether you're a diehard owl enthusiast or a casual admirerer. You'll find yourself wanting to leave this book somewhere conspicuous, so you can show the images off to friends, family, and unwary passersby. -- Jim Cirigliano Bird Watcher's Digest 2009Table of ContentsAcknowledgmentsIntroduction: Owl Addiction1. Anatomy of an OwlPaleocene OriginsWMDs: Weapons of Mouse DestructionOn Wings That WhisperColors that DisguiseFretting with Feathers2. Son et LumiereSound AdviceThe Handicap of DarknessThe Eyes of OwlsThe Nocturnal Syndrome3. Haunts and HideawaysFrom Tundra and Taiga to Mountains and MarshlandsFloatersHot and Cold Weather WoesRoost RewardsFleeing from Winter4. Owl InvasionsThe Owlish AppetiteFoods That Fight BackPellet DiariesHunting TechniquesHoarding for Hard Times5. Family LifeWho Gives a Hoot?Courtship ConductHouse HuntingThe Cloacal KissOology 101The Tedium of IncubationSexual Dimorphism: The Great Debate6. The Next GenerationEarly Chick LifeAsynchronous Hatching: A StrategyLife in the NestRoamers, Branchers, and HomebodiesThe Young and the Restless7. Predators, Pirates, and PestsKleptoparasitismA Call to Arms8. Owls and HumansHIPPOAppendix: Scientific Names of Plants and AnimalsReferencesIndex
£45.97
Johns Hopkins University Press Biology of the Snapping Turtle Chelydra
Book SynopsisUltsch, University of Alabama; Nigel H. West, University of SaskatchewanTrade ReviewBiology of the Snapping Turtle is a well-executed volume filled with useful information. Herpetological Review 2008
£69.00
Johns Hopkins University Press Nested Ecology
Book SynopsisIn doing so, Wimberley defines a new environmental philosophy and a new ecological ethic.Trade ReviewThis book makes for salutary reading for anyone who is seeking to understand current ecological thinking-and for a lawyer in particular it is hugely thought-provoking. -- Karen Morrow Journal of Environmental Law 2011 Wimberley's concept of nested ecology is essential to rethinking the human role within the universe's natural ecological progression. -- Scott Obernesser Interdisciplinary Studies in Literature and Environment 2011Table of ContentsForeword, by John F. HaughtPreface1. Developing a Practical and Sustainable Ecology2. Personal Ecology3. Social Ecology4. Environmental Ecology5. Cosmic Ecology and the Ecology of the Unknown6. Essential Characteristics of Nested Ecology7. The Fundamentals of Nested Ecological HouseholdingEpilogueReferencesIndex
£55.50
Johns Hopkins University Press Nested Ecology The Place of Humans in the
Book SynopsisIn doing so, Wimberley defines a new environmental philosophy and a new ecological ethic.Trade ReviewThis book makes for salutary reading for anyone who is seeking to understand current ecological thinking-and for a lawyer in particular it is hugely thought-provoking. -- Karen Morrow Journal of Environmental Law 2011 Wimberley's concept of nested ecology is essential to rethinking the human role within the universe's natural ecological progression. -- Scott Obernesser Interdisciplinary Studies in Literature and Environment 2011Table of ContentsForeword, by John F. HaughtPreface1. Developing a Practical and Sustainable Ecology2. Personal Ecology3. Social Ecology4. Environmental Ecology5. Cosmic Ecology and the Ecology of the Unknown6. Essential Characteristics of Nested Ecology7. The Fundamentals of Nested Ecological HouseholdingEpilogueReferencesIndex
£31.50
Johns Hopkins University Press Understanding Mathematics
Book SynopsisFeaturing end-of-chapter exercises and suggestions for further reading, this succinct account is a great resource for students of biological or environmental sciences as well as professionals seeking to brush up on basic skills.Trade ReviewRecommended. Choice 2011Table of ContentsPreface1. Fundamentals1.1. Why Mathematics?1.2. What's It All About?1.2.1. x?1.2.2. Mathematics?1.2.3. Functions and Equations1.2.4. Relationships1.2.5. Why Don't We Speak Mathematics All the Time?1.2.6. And Why Do I Need to Understand It?1.3. Working with Equations1.3.1. Rearranging Equations1.3.2. Order of Evaluating Algebraic Expressions1.3.3. Some Useful Algebraic Relationships1.3.4. A Word about Calculators14. Exercises15. Answers2. Numbers2.1. Decimal Number Representation2.1.1. Significant Figures and Decimal Places2.1.2. Scientific Notation2.2. Binary and Hexadecimal Numbers2.2.1. Binary Numbers2.2.2. Conversion from Decimal to Binary2.2.3. Hexadecimal Numbers2.2.4. Conversion from Decimal to Hexadecimal2.2.5. Binary-Hex Conversion2.3. Preliminary Calculations: Check the Problem2.3.1. Dimension AnalysisApplication: How Much Rain Flows into the Oceans?2.3.2. A Rough Calculation on the Back of an Envelope2.4. Exercises2.5. Answers3. Powers and Logarithms3.1. Powers and Indices3.1.1. Some General Rules of Powers and Indices3.1.2. Rules of Powers and Indices: Summary3.2. Logarithms3.2.1. What Are Logarithms?3.2.2. DefinitionCommon LogarithmsNatural Logarithmse: An Interesting Number3.2.3. Mathematical Derivation of the Rules of Logarithms3.2.4. Calculating Logarithms to a Different Base3.2.5. Rules of Logarithms: Summary3.3. Population Dynamics and the Exponential Equation3.4. Exercises3.5. Answers4. Calculations and Applications4.1. Convert Miles/Hour (mph or miles hour-1) to m s-14.2. Body Mass Index (lb/in2)4.3. The pH of a Solution4.4. How Many Microbes? The Viable Count Method4.5. Surface Area of Humans4.6. Blood Flow in the Arteries4.7. The Growth of a Bacterial Population4.8. Light Passing Through a Liquid4.9. A Water Pollution Incident4.10. The Best Straight Line4.10.1. Notation for Sums of Sequences4.10.2. Fitting the Best Straight Line4.11. The Michaelis Menton Equation4.11.1. The Lineweaver-Burke Transformation4.11.2. The Eadie-Hofsee Transformation4.11.3. Fitting the Parameters the Modern Way4.12. Graphs and Functions4.12.1. Plotting Graphs4.12.2. Shapes of Some Useful Functions5. Neat Tricks and Useful Solutions5.1. The Difference of Two Squares5.2. Mathematical Induction5.3. Pythagoras' Theorem5.4. Pythagoras' Theorem Revisited5.5. Limits5.6. Trigonometry: Angles with a Difference5.6.1. Radians and Degrees5.6.2. Trigonometric Ratios: Sine, Cosine, TangentApplication: Radiation on a SurfaceApplication: What Force on the Biceps?5.7. Numerical Calculations5.7.1. Iteration5.7.2. The Method of Iteration5.7.3. The Method of Bisection6. Differential Calculus6.1. Introduction6.2. What Is Differentiation?6.1. Distance and Velocity6.2. Average Velocity6.3. Instantaneous Velocity6.4. The Differential Coefficient of Any Function6.5. Differentiability6.6. Evaluation of Some Standard Derivatives6.7. Derivatives Involving Two Functions6.8. The Chain Rule6.9. Optimum Values: Maxima and MinimaApplication: How Fast Should a Fish Swim?6.10. Small Errors6.11. Summary Notes on Differentiation6.11.1. Standard Derivatives6.11.2. Rules for Differentiation6.11.3. Maxima and Minima6.12. ApplicationsEquation for Radioactive DecayHalf-LifeFitting the Best Line: The Method of Least SquaresCylinder of Minimum Surface Area6.13. Exercises6.14. Answers7. Integral Calculus7.1. Introduction7.2. Integration as the Area under a Curve7.2.1. Area of a Circle 17.2.2. Area of a Circle 27.3. Techniques of Integration7.3.1. The Chain Rule7.3.2. Integration by Parts7.4. Summary Notes on Integration7.4.1. Standard Integrals7.4.2. Techniques7.5. ApplicationsMean ValueSurfaces and Volumes of RevolutionEquations of MotionPollution of a Lake7.6. Exercises7.7. Answers8. Matrix Algebra8.1. Introduction8.2. What Is a Matrix?8.3. Developing the Algebra8.3.1. Equality of Matrices8.3.2. Addition of Matrices8.3.3. Subtraction of Matrices8.3.4. Zero or Null Matrix8.3.5. Transpose Matrix8.3.6. Identity Matrix8.3.7. Multiplication by a Scalar8.3.8. Matrix Multiplication8.4. ApplicationsPopulation DynamicsUsing Matrix Multiplication to Rotate CoordinatesFinding Pathways8.5. Determinants8.5.1. The Determinant of a 3 3 Matrix8.5.2. Minors and Cofactors8.5.3. Area of a Triangle8.5.4. Some Properties of Determinants8.6. The Inverse Matrix8.6.1. Solution of (Lots of) Simultaneous Equations8.6.2. Eigenvalues and Eigenvectors9. Statistics9.1. Introduction9.2. The Statistical Method9.3. Basic Statistics9.3.1. Mean9.3.2. Variance9.3.3. Standard Deviation9.3.4. Standard Error (of ...)9.4. The Normal Frequency Distribution9.5. The t-Test: Are Two Means Different?9.6. How to Perform a t-Test9.7. Is the Data from a Normal Distribution?9.8. The 2 Test for Frequencies9.8.1. Degrees of Freedom9.8.2. Contingency Tables: Are Hair and Eye Color Related?9.9. The Mann-Whitney Test: Are Two Samples Different?9.10. One-Tailed Tests10. The End of the BeginningFurther ReadingIndex
£82.65
Johns Hopkins University Press Kingdom of Ants Jos Celestino Mutis and the Dawn
Book SynopsisA unique glance into the early world of science exploration, Kingdom of Ants is a delight to read and filled with intriguing information.Trade ReviewEdward O. Wilson, one of those rare scientists who can make biology and science history not only readable but entertaining, has written a book that holds the reader's attention from beginning to end. -- Lynne M. Hinkey Internet Review of Books 2011 By coupling excerpts from Mutis's forgotten diaries with recent findings on ant eating habits, reproductive behaviors, and emigration patterns, the authors give new relevance to one of the New World's oldest natural history studies. This interesting writing technique helps readers understand the continual nature of the process of scientific inquiry. Choice 2011 A unique glance into the early world of science exploration, Kingdom of Ants is a delight to read and filled with intriguing information. Southeastern Naturalist 2011Table of ContentsPrologue1. Who Was Mutis?2. The Making of an Eighteenth-Century Naturalist3. The Scientific Contributions of José Celestino Mutis4. Mutis Seeks Advice5. Mutis Begins His Study of Ants6. Ants Are Transported by Ships7. Ant Plants and Plant Ants8. Mutis Learns about the Mule-Train (Leafcutter) Ants9. Unending Struggles against the Mule-Train Ants10. Ant Wars11. Mutis Solves the Mystery of the Nomadic Pataloas12. Mutis Measures the Size of an Army-Ant Colony13. Mutis Tracks the Armies of Ants14. Mutis Studies the Gender of Ants and Makes an Amazing Discovery15. Mutis' Other Ants16. How Good a Scientist Was Mutis?EpilogueAcknowledgments
£29.12
Johns Hopkins University Press Rabbits
Book SynopsisLumpkin and Seidensticker talk about conservation, because while rabbits may breed like, well, rabbits, several species are among the most endangered animals on Earth.Trade ReviewRabbits: The Animal Answer Guide is the one resource you will need to learn about rabbits' anatomy and physiology, evolutionary history, ecology, behavior, and their relationships with humans. Northeastern Naturalist 2011Table of ContentsAcknowlegmentsIntroduction1. Introducing RabbitsWhat are lagomorphs?What is the difference between rabbits, hares, and pikas?Is this book about rabbits, hares, pikas, or all three?How many kinds of rabbits are there?How are rabbits classified?Why are rabbits important?Why should people care about rabbits?How did rabbits evolve?When did rabbits evolve?What is the oldest fossil rabbit?What were the largest and smallest fossil rabbits?2. Form and Function of RabbitsWhat are the largest and smallest living rabbits?What is the metabolism of a rabbit?Why is rabbit scat round?Why are rabbits always sniffing?Why do rabbits have a "hare lip"?Is it true that rabbit teeth never stop growing?Do rabbits sleep?Can rabbits see color?Do all rabbits have big ears and short tails?Why do rabbits have whiskers?Can rabbits run?Can rabbits swim?3. Rabbit ColorsWhy are so many rabbits brown?What causes the fur colors of rabbits?Do fur colors change in different seasons?What color are a rabbit's eyes?What color are baby rabbits?Are there albino rabbits?4. Rabbit BehaviorAre rabbits social?Do rabbits fight? Do rabbits bite?How smart are rabbits?Do rabbits play?Do rabbits talk?Who eats rabbits?5. Rabbit EcologyWhere do rabbits live?Where do rabbits sleep?Do rabbits migrate?Which geographic regions have the most species of rabbits?Which rabbits have the largest distributions and which the most restricted?How do rabbits survive in the desert?How do rabbits survive in the winter?Do rabbits hibernate?Do rabbits get sick?Are rabbits good for the environment?6. Reproduction and Development of RabbitsHow do rabbits reproduce?How long are female rabbits pregnant?Where do rabbits give birth?Do rabbits nest at the same time and in the same place every year?How many babies do rabbits have?Are all babies in a rabbit's nest full siblings?Do rabbits care for their young?How fast do rabbits grow?How can you tell the age of a rabbit?How long do rabbits live?7. Rabbit Foods and FeedingWhat do rabbits eat?How much do rabbits chew their food?How do rabbits find food?Do rabbits drink water?Do rabbits ever store their food?8. Rabbits and HumansDo rabbits make good pets?How were rabbits domesticated?Why did people say "the rabbit died" to mean a woman was pregnant?Are rabbits used in a lot of experiments?Do rabbits feel pain?What if I find a baby rabbit or an injured rabbit or if I hit one with my car?How can I see rabbits in the wild?Should people feed rabbits?9. Rabbit Problems (from a human viewpoint)Are rabbits pests?How can I keep rabbits out of my garden?Are rabbits bad for lawns?Are rabbits dangerous?Is it safe to eat rabbits?What should I do if I get bitten by a rabbit?10. Human Problems (from a rabbit's viewpoint)Are any rabbits endangered?Will climate change affect rabbits?Are rabbits affected by pollution?Why do people hunt and eat rabbits?What products are made from rabbits?Why do so many rabbits get hit by cars?Do house cats kill rabbits?What can an ordinary citizen do to help rabbits?11. Rabbits in Stories and LiteratureWhat roles do rabbits play in mythology and religion?What roles have rabbits played in language and literature?What roles do rabbits play in popular culture?12. "Rabbitology"Who studies rabbits?Which species are best known?Which species are least known?How do scientists tell rabbits apart?How can I become an expert on rabbits?Appendix: Rabbits of the WorldBibliographyIndex
£41.50
Johns Hopkins University Press Rabbits The Animal Answer Guide The Animal Answer
Book SynopsisLumpkin and Seidensticker talk about conservation, because while rabbits may breed like, well, rabbits, several species are among the most endangered animals on Earth.Trade ReviewRabbits: The Animal Answer Guide is the one resource you will need to learn about rabbits' anatomy and physiology, evolutionary history, ecology, behavior, and their relationships with humans. Northeastern Naturalist 2011Table of ContentsAcknowlegmentsIntroduction1. Introducing RabbitsWhat are lagomorphs?What is the difference between rabbits, hares, and pikas?Is this book about rabbits, hares, pikas, or all three?How many kinds of rabbits are there?How are rabbits classified?Why are rabbits important?Why should people care about rabbits?How did rabbits evolve?When did rabbits evolve?What is the oldest fossil rabbit?What were the largest and smallest fossil rabbits?2. Form and Function of RabbitsWhat are the largest and smallest living rabbits?What is the metabolism of a rabbit?Why is rabbit scat round?Why are rabbits always sniffing?Why do rabbits have a "hare lip"?Is it true that rabbit teeth never stop growing?Do rabbits sleep?Can rabbits see color?Do all rabbits have big ears and short tails?Why do rabbits have whiskers?Can rabbits run?Can rabbits swim?3. Rabbit ColorsWhy are so many rabbits brown?What causes the fur colors of rabbits?Do fur colors change in different seasons?What color are a rabbit's eyes?What color are baby rabbits?Are there albino rabbits?4. Rabbit BehaviorAre rabbits social?Do rabbits fight? Do rabbits bite?How smart are rabbits?Do rabbits play?Do rabbits talk?Who eats rabbits?5. Rabbit EcologyWhere do rabbits live?Where do rabbits sleep?Do rabbits migrate?Which geographic regions have the most species of rabbits?Which rabbits have the largest distributions and which the most restricted?How do rabbits survive in the desert?How do rabbits survive in the winter?Do rabbits hibernate?Do rabbits get sick?Are rabbits good for the environment?6. Reproduction and Development of RabbitsHow do rabbits reproduce?How long are female rabbits pregnant?Where do rabbits give birth?Do rabbits nest at the same time and in the same place every year?How many babies do rabbits have?Are all babies in a rabbit's nest full siblings?Do rabbits care for their young?How fast do rabbits grow?How can you tell the age of a rabbit?How long do rabbits live?7. Rabbit Foods and FeedingWhat do rabbits eat?How much do rabbits chew their food?How do rabbits find food?Do rabbits drink water?Do rabbits ever store their food?8. Rabbits and HumansDo rabbits make good pets?How were rabbits domesticated?Why did people say "the rabbit died" to mean a woman was pregnant?Are rabbits used in a lot of experiments?Do rabbits feel pain?What if I find a baby rabbit or an injured rabbit or if I hit one with my car?How can I see rabbits in the wild?Should people feed rabbits?9. Rabbit Problems (from a human viewpoint)Are rabbits pests?How can I keep rabbits out of my garden?Are rabbits bad for lawns?Are rabbits dangerous?Is it safe to eat rabbits?What should I do if I get bitten by a rabbit?10. Human Problems (from a rabbit's viewpoint)Are any rabbits endangered?Will climate change affect rabbits?Are rabbits affected by pollution?Why do people hunt and eat rabbits?What products are made from rabbits?Why do so many rabbits get hit by cars?Do house cats kill rabbits?What can an ordinary citizen do to help rabbits?11. Rabbits in Stories and LiteratureWhat roles do rabbits play in mythology and religion?What roles have rabbits played in language and literature?What roles do rabbits play in popular culture?12. "Rabbitology"Who studies rabbits?Which species are best known?Which species are least known?How do scientists tell rabbits apart?How can I become an expert on rabbits?Appendix: Rabbits of the WorldBibliographyIndex
£29.44
