Veterinary medicine Books

Book SynopsisThis field guide should be useful for veterinary practitioners and veterinary students. Murphy covers all aspects of common animal poisons and provides references for more in-depth research. As a text, the book is designed for teaching applied aspects of veterinary toxicology.Table of ContentsPreface. Acknowledgements. Abbreviations.. I. Prevalence of Animal Exposures to Toxins. II. Treatment regimens. III. Toxin Summaries. Adverse Drug Reactions. Neurological System. Neurological System. Gastrointestinal System. Renal System. Hepatic System. Dermal System. Respiratory System. Respiratory System. Cardiovascular System. Hematopoietic System. Hematopoietic System. Musculoskeletal System. Reproductive System.. IV. Selected Bibliographies. V. Additional Sources of Information. VI. Indices to Toxins by:. Clinical Sign. Diagnostic test result. Toxin name, system, and LD. Response form.

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Book SynopsisThe final volume of Catanzaro''s benchmark series on building a veterinary practice, this is also the series'' keystone, providing the ways and means to keep a veterinary business going and growing under all sorts of circumstances. Creativity is the key to healthy change, and it is also the key to Catanzaro''s approach as he helps the vet and clinic staff to colour outside the lines--to think in new ways that will enhance procedures and employee morale in any practice. A noted veterinary practice management consultant, Catanzaro draws on his own extensive experience and that of other consultants, writers, and speakers to bring together the essential tools for individual brainstorming and organisational restructuring. Liberally illustrated with examples, tables, chats, and forms, and full of exercises for stimulating creativity, this volume focuses on hiring strategies and job redesign, establishing leadership and building a client base, learning and teaching new techniques, and, laTable of ContentsPREFACE; INTRODUCTION; Evolving Perspectives of Veterinary Practice; The Right Person for the Right Job; Creative Client Power-Up; Leadership before Delegation; Building the Learning Environment; Appendices: Empowering the Team; Styles of Training Profile; How to Hire a Winner; 101 Veterinary Practice Management Gimmicks; Computerised Medical Records; Medical Record Audits; Do the Unusual as if It Were Usual; Coping Self-Assessment; Team Creativity Exercises; Leadership Profile in the New American Veterinary Practice.

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Book SynopsisNow in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.Trade Review"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011) Table of ContentsCoauthors. Preface. 1 Introduction. 2 Principles of Drug Movement in the Body. 3 Quantitative Structure–Permeability Relationships (Xin-Rui Xia). 4 Absorption. 5 Distribution (with Jennifer Buur). 6 Renal Elimination. 7 Hepatic Biotransformation and Biliary Excretion (Ronald Baynes). 8 Compartmental Models. 9 Noncompartmental Models. 10 Nonlinear Models. 11 Physiological Models (Teresa Leavens). 12 Dosage Regimens. 13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (Pierre-Louis Toutain). 14 Study Design and Data Analysis. (Jason Chittenden). 15 Bioequivalence Studies (Marilyn Martinez). 16 Population Pharmacokinetic Models (Jason Chittenden). 17 Dosage Adjustments in Disease States (Jennifer Davis). 18 Interspecies Extrapolations. 19 Tissue Residues and Withdrawal Times (Sharon Mason). Index.

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Book SynopsisMany students and even researchers often make the mistake of using too few or too many animals in their experiments. This can lead to misleading results or waste of animal resources. Drawing on examples from animal experiments this book illustrates the general principles of experimentation and analysis.Unlike other textbooks on statistics, this title will enable the student to better judge which tool might be appropriate to particular circumstances:An essential textbook for advanced undergraduates and graduate studentsA user-friendly guide for the design and analysis of experiment in animal scienceThe only textbook of its kind.Table of Contents1: Introduction- The Principles of Good Experiments 2: Blocking 3: Separating Treatment Means 4: How Many Animals 5: Change-Over Designs 6: Pens and Paddocks 7: Factorial Designs 8: Assumptions Underlying the Analysis of Variance 9: Dose-Response Trials 10: Uses of Covariance Analysis 11: Unbalanced Designs 12: Repeated Measures 13: Discrete Data 14: Multiple Experiments 15: List of Appendices

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Book SynopsisThere are currently many controversial socioeconomic issues concerned with the development and implementation of agricultural biotechnology. This book presents selected revised and edited papers from the fourth and fifth meetings of the International Consortium on Agricultural Biotechnology Research, held in Italy in 2000 and 2001.Table of Contents1: Introduction 2: From the Green Revolution to the Gene Revolution, Robert Evenson Part I: Intellectual Property Rights and Technological Exchange 3: Conflicts in Intellectual Property Rights in Genetic Resources: Implications for Agricultural Biotechnology 4: Sui generis Protection of Plant Varieties in Asian Agriculture: a Regional Regime in the Making? 5: Intellectual Property Aspects of Traditional Agricultural Knowledge, 6: Farmers' Rights and Intellectual Property Rights - Reconciling conflicting concepts, Part II: Public-Private Issues 7: Universities, Technology Transfer and Industrial R&D, 8: Mergers and Intellectual Property in Agricultural Biotechnology 9: Cost of Conserving Genetic Resources at ex situ Genebanks: An Example of the ICARDA Genebank Part III: The Role of Methods 10: Impact of Terminator Technologies in Developing Countries: A Framework for Economic Analysis, 11: The Impact of Genetic Use Restriction Technologies on Developing Countries: a Forecast, 12: Managing Proprietary Technology in Agricultural Research, 13: Is Marker-assisted Selection Cost-effective Compared with Conventional Plant Breeding Methods? The Case of Quality Protein Maize, Part IV: Developing Country Biotechnology Experience 14: Can Biotechnology Reach The Poor? The Adequacy Of Information and Seed Delivery 15: Value of Engineered Virus Resistance in Crop Plants and Technology Cooperation with Developing Countries, 16: Institutions and Institutional Capacity for Biotechnology - A Case Study of India, 17: Social and Economic Impact Ex-Ante Evaluation of Embrapa's Biotechnology Research Products, 18: Intellectual Property Protection and the International Marketing of Agricultural Biotechnology: Firm and Host Country Impacts, 19: Efficiency Effects of bt Cotton Adoption by Smallholders in Makhathini Flats, KwaZulu-Natal, South Africa, 20: Income and Employment Effects of Transgenic Herbicide-resistant Cassava in Colombia: A Preliminary Simulation, Part V: International Models 21: Estimating the Economic Effects of GMOs: the Importance of Policy Choices and Preferences 22: Smallholders, Transgenic Varieties and Production Efficiency: The Case of Cotton Farmers in China

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Book SynopsisWhether castrating horses or tending to stoned Alsatians, Gillian Hick's sense of humour never deserts her in this engaging account of her life as a vet.Trade Review'This book is just hilarious. Suffice to quote the story of Gillian being called out to tend a guard dog called Rambo, who 'could best be described as a cross between a Rhodesian Ridgeback and a Rottweiler, with a bit of German Shepherd thrown in for good measure'. When she nervously approaches the giant beast in his kennel, the diagnosis was obvious. 'Rambo was stoned'. It emerged that the vigilent guard dog had chased off a drug dealer -- then consumed the prohibited substances abandoned in the persuit. This is Gillian Hick's first book, but will no doubt be the first of many in the James Herriot mould.' -- Countryman'An enjoyable light-hearted look behind the scenes at the world of veterinary medicine. Buy it for a would-be veterinary student or anyone who comes from a farming background - it's sure to please.' -- The Irish WorldIt's an engaging account of the situations she encounters where the humans are often more problematic than the animals, particularly the guys who want to know where the real vet is.' -- The Irish Independent * Irish Independent *'Lively sense of humour, and a pleasant, easy-going writing style. Animal lovers will be well-pleased with her pacy anecdotes' -- Irish Examiner * The Irish Examiner *'Gillian is not afraid to tell of her failures, nor is she ashamed to admit to shedding a few tears from time to time. There is nothing boastful or egotistical. It is very well written in an easy-flow style, and it would make a lovely ... present for an animal lover, especially one who does not object to gory details.' -- Irish Farmer's Journal

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Book SynopsisAdventure-tale devotees and conservationists will enjoy this veterinarian's memoir on treating and studying African wildlife.Trade Review"Haigh's writing style is informative and entertaining all in the same breath. His stories weave animal history and legend together with his own experiences to create a vivid picture of the wildlife situation in Africa... While the title of the book may lead you to believe it is just about the king of the jungle, the cast of animal characters is quite varied. Haigh has tended to rhinos, elephants, wild dogs, hyenas, chimpanzees, cattle, and many other creatures, both large and small in the wilds of Africa. The Trouble with Lions gives you a closer look at the wild animals that once roamed free and plentiful across a continent; you'll find no better guide than Dr. Jerry Haigh." Carmen Klassen, The StarPhoenix, June 28, 2008 "Going on safari in Africa is something most people may have on their bucket list. In his memoir of his life and work while living in Africa, author Jerry High, a Glasgow-schooled veterinarian takes the reader through Kenya Now and Then (1965-1975), Forested Africa and the Bushmeat Crisis (1995-2007), The Trouble with Lions (1997), and On the Ground in Uganda (2002-2007). Thoughtfully written and including captivating photos; will delight readers. Recommended for adult readers." Tonya Thul-Theis, Reviewer's Bookwatch, October 2008 "Have you ever had the experience of meeting someone who makes a distant part of the world, or a different way or life, make sense to you for the first time? Reading Jerry Haigh's 'The Trouble With Lions' is like that. There are many good story tellers out there, and Haigh is one of them. But here's the big difference--he has decades of unique, fascinating experience to back it up. He's a wildlife veterinarian, and his tales of treating lions, and rhinos, and all sorts of other animals in Africa are fascinating--they're like James Herriot's 'All Creatures Great and Small,' except it's All Creatures Great and Greater. But as fun, and often funny, as Haigh's tales are, the real value of 'The Trouble With Lions' lies in the way he sees the world, and the ways in which humans relate to each other and to the wildlife and nature around them. This isn't just a book about one man's experiences. It's a story about Africa, and its people, and its wildlife, and the dramatic, often heartbreaking changes all three have experienced over the last 4 decades. 'The Trouble With Lions' is an excellent book for lovers of Africa, and adventure, and a good tale well told. But it will also provide valuable context and open readers' eyes to the deep connections between animals and nature and current events--like the ongoing conflict in the Congo, and last year's post-election violence in Kenya. Highly recommended." Thomas Hayden, San Francisco, CA, December 23, 2008 "Fascinating, educational, funny and beautifully illustrated, this book gives us a glimpse of the life of a veterinarian working in modern-day Africa. Lions, rhinos and chimpanzees are among the animals Dr. Haigh treats and they are all sadly under great stress and pressure as their natural habitat slowly disappears." Juror, Saskatchewan Book Awards, 2008 "Jerry Haigh takes us into the world of rhinos and lions in Africa and describes his adventures with clear insight and compassion." Juror, Saskatchewan Book Awards, 2008 "This is a beautifully told, rich account of another landscape, another country; Jerry Haigh weaves an endlessly complex and layered tale of humans and animals." Juror, Saskatchewan Book Awards, 2008 "The Trouble with Lions chronicles the adventures of a veterinarian in Africa, escorting us far off the beaten path of nature documentaries and tourist safaris, ultimately breaking our hearts with the overwhelming evidence that Africa's great cavalcade of beasts and wild places will disappear in our lifetime." Juror, Saskatchewan Book Awards, 2008 "The Trouble with Lions, Jerry Haigh's fast-paced memoir of his years practicing wild-animal medicine in the jungles and plains of Africa, is as disturbing as it is fascinating: a rare glimpse into a little-known and quickly vanishing world." Juror, Saskatchewan Book Awards, 2008 "Haigh (veterinary medicine, U. of Saskatchewan), a hearty type with few complaints about living rough alongside his patients, explains the pressures of keeping animals alive and at peace with the humans around them, a difficult task at best and often heartbreaking. He describes preservation efforts and how they apply to elephants, rhinos, painted dogs, and the various species dubbed 'bushmeat.' He explores the national park system set up to keep animals and humans as happy and well-fed as possible, the trouble with well-meaning amateurs, and the need for continuous education about some of the most fascinating creatures in the world." SciTech Book News, December 2008 "He has wrestled rhinos, elephants and lions in Africa, studied seals on Sable Island, tested reindeer in Mongolia and carried out research work on bison, deer, elk and polar bears in Canada. He continues to work on the front lines of what he calls 'the longest running wars on the planet - the war between wild animals and humans.' ... Haigh ... was veterinarian at the Saskatoon Zoo for 16 years, and has been a member of the faculty of the Western College of Veterinary Medicine since 1975. ... In February 2008, Haigh and his wife took their sixth group of ten students to Uganda. A total of 59 students have participated since he set up the program in 2003. Several students from Africa also take the course concurrently and this is leading to ongoing cross-cultural professional association." Robert White, The Neighbourhood Express, March 30, 2008 "Of the 60 authors nominated for 2008, I'm willing to wager he's the only one that's ever performed an enema on a rhino. The incident isn't recounted in Jerry Haigh's The Trouble with Lions, which was nominated in the Nonfiction and Saskatoon Book categories. Instead it was included in his first book about his four decades working as a wildlife vet in Africa called Wrestling with Rhinos. Lions, however, has its share of fascinating stories and insights into a continent that, as the cradle of humanity and home to all manner of exotic animal species, exerts a strong hold on our imagination." Gregory Beatty, Planet S, December 4, 2008 "Jerry Haigh has spent more than 40 years in Africa, in Kenya, Uganda, Cameroon, Namibia, South Africa, Botswana, Zimbabwe, Zambia, Malawi, DRC and Tanzania. As with many vets in Africa, he became involved with treating the problems of wild animals, and was among the first to perfect the art of capturing and translocating animals with drugs rather than with a pole and a rope. He started as an intern at the Kabete Vet Lab, and then spent five years as the Government vet in Meru, before starting a private practice in Nanyuki. Along with the normal cats, dogs, parrots, horses and cattle, his patients also included rhino, chimpanzees, roan antelope, elephants, zebras, warthogs, birds, and Uganda kob. However, he regards one animal as being a symbol of what is happening to wildlife in Africa, and that is the lion. The decline of lion numbers reflects the way things have changed and are changing for all wildlife in Africa, and are symbolic of all wildlife species, not only in Africa, but worldwide. After his spell in Kenya, he and his family moved to Canada, but he was soon back, putting tracking collars on forest elephants in Cameroon. Here he became aware of the enormity of the horrendous bush meat problem (more than 5 million tons a year, according to 2004 figures), and the problems of illegal logging and habitat destruction. He studied the effects of the bushmeat trade, and was not alone in concluding that SARS, HIV, Ebola and Marburg's disease in humans are directly related to eating or handling animal (especially primate) meat. Dr Haigh also spent time working with rare white rhinos in South Africa, and African wild dogs in Namibia and Botswana. He instigated a programme of taking Canadian vet students to Uganda where they received far more hands-on experience than they ever could at home. But throughout his travels he has continued to learn more about lions--distribution, traditions, superstitions, witchcraft, the history of stock attacks--and has examined in great detail the problem of declining lion numbers. Having worked with other vets and wildlife experts all over the continent, such as Paul Sayer, Dieter Rottcher, Toni Harthoorn, Gladys Kalema, Laurence Frank, and Annie Olive-Krona, Dr Haigh is well informed on all matters concerning wildlife, but particularly with the subject of people living alongside lions. This is a well-written book, full of interesting facts and entertaining people." Jean Hartley, ViewFinders Ltd "I have heard Dr Haigh lecture several times; he is always entertaining, and my hope was that his writing would be equally enjoyable. I was not disappointed... Haigh's discussion of the plight of the African lion, and his use of the lion as a symbol for the precarious future for Africa's wildlife, is very insightful. A central theme throughout the book is the complex relationships between humans, their livestock, and the Wildlife... I would recommend The Trouble with Lions for an entertaining but worthwhile read from one of the pioneers of wildlife veterinary medicine. It would make a great companion on a long flight, or a long layover (to Africa, perhaps?), or for someone wrapped up in front of the fire on a cold, prairie-winter's night dreaming of warm, exotic locales." Jonathan Mark Sleeman, Virginia Department of Game and Inland Fisheries, Journal of Wildlife Diseases, April 2009 "Jerry Haigh has written a book that is both an interesting read as well as being informative and thought provoking. He manages to balance his own personal, often funny anecdotes of just being a vet and all the challenges that that entails with the more serious subject of wildlife conservation and the problems and conflicts that face local people as well as the authorities and generally puts forward a good unbiased viewpoint. Before reading this book, I had no idea how complex the situation is. I also found it interesting to see how much things have changed over the many years that Jerry has been working with wildlife and how much of a trailblazer he was in his early years of treating and translocating animals. It is all written in an easy conversational style - even though he goes off at a tanget sometimes - with lots of personal touches. I noticed, for example, that when particular incidents are described, they are often associated with what he had to eat at the time! Well worth reading." Frances M. Rees, January 26, 2009 "From North American Bison to African Rhino, this book gives the reader an insight into what is happening in today's African wildlife and human conflict from a veterinarian's perspective. Dr Haigh brings us along on his journey to Africa with Canadian Veterinary students." Pauline Gaudette, December 29, 2008 "This is a book that will appeal to all those, whether veterinarians or not, with a concern for wildlife conservation, and draws on the author's considerable experience of the issues involved while working in sub-Saharan Africa. It is prefaced by an introduction from the world-renowned primatologist Jane Goodall." Roland Minor, Veterinary Record, Janaury 23, 2010 [Full review at doi: 10.1136/vr.c362]

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Book SynopsisThis concise, practical text covers the essential information veterinary students need to succeed in equine medicine and surgery, focussing on skin, urinary, liver and endocrine diseases. Written for an international readership, the book conveys the core information in an easily digestible, precise form with extensive use of bullet points, tables, flow charts, diagrams, lists, protocols and extensive illustrations.Part of a five-book series that extracts and updates key information from Munroe's Equine Surgery, Reproduction and Medicine, Second Edition, the book distils best practice in a logical straightforward clinical-based approach. It details clinical anatomy, physical clinical examination techniques, diagnostic techniques and normal parameters, emphasising the things regularly available to general practitioners with minimal information of advanced techniques.The liver section is divided into clinical evaluation, diagnostic tests, possible causes andTrade Review"Veterinary students would love this! I have seen the success of similar books in small animal medicine and how useful they can be on rotations when a quick reference is needed. I think it would equally be of benefit to residents and practitioners needing quick refreshers." Carla Lusi, University of Melbourne, Australia, author of Fascial Anatomy of the Equine Forelimb (CRC Press) "I think this Equine textbook will be exceptionally well received. Although the original book Equine Clinical Medicine, Surgery and Reproduction really helped me personally through university, I could only ever use it at my desk or at the library. More concise books allow students and new grads to have them at hand all the time, especially during rotations for quick reference. Leave the 1500 page book at home and take just what they need for the day! Each disease or syndrome has the same layout, allowing a vey quick reference, and the images are amazing. They are good quality and allow very immersive learning." Sophie Neasham, Veterinary surgeon, UK "While the volume Equine Clinical Medicine, Surgery and Reproduction, Second Edition is a great resource for reference, say, when wanting to research differential diagnoses for a case or brush up on a disease, it is not practical to be used out in the field. This smaller, more focused reference guide is more amenable to practical day-to-day veterinary use. For example, when out on a call and you need a quick reference on how to treat a specific presentation, having a resource which is concise and targeted is more user friendly than a large volume." Rachael Harmer, Veterinary Medicine student at the University of Surrey (2016-2021), UK Table of ContentsLiver Disease. Endocrine System. Urinary System. Skin.

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Book SynopsisA Professional's Guide to Feline Behaviour is an invaluable resource for the feline professional, yet written in such an accessible way that it would be of interest to anyone who shares their life with a cat and wants to gain a deeper understanding of their behaviour.The book is presented in easy-to-navigate sections, each packed with practical advice and the colour illustrations, tables and graphics throughout make it approachable for every type of reader.What this guide offers: A greater understanding of cats and how to meet their needs. How to recognise and mitigate negative emotions and deal with challenges that cats face both at home and particularly in the workplace. How to analyse feline behaviour accurately, with a view to designing a tailored behaviour modification plan. Comprehensive information on common, and not so common, problematic feline behaviours. The fundamentals of learning theory, with step-by-step training guides. Real-life case studies, accompanied by behaviour plans that integrate clinically proven methods to help manage or resolve a range of behaviour issues. Written by Caroline Clark, a Registered Clinical Animal Behaviourist and RCVS listed veterinary nurse, this well-researched book draws from her knowledge and professional experiences, offering a unique insight into feline behaviour.

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Book SynopsisThis second edition of Small Animal Cytologic Diagnosis presents clinically applicable information about the use of cytology in small animals and indicates when advanced diagnostic testing can be beneficial to diagnose underlying disease processes. It includes more images, additional cases, and a new user-friendly chapter organization.This book discusses the pathophysiology of inflammation, cancer biology, and comparisons to histology to help readers fully comprehend the cytologic changes that can occur with inflammation and neoplasia. Also covered are some of the limitations and advantages of cytology compared to histopathology, important gross findings (e.g. body cavity effusions), and parasites and the associated diagnostic methods required. Further information is provided on oncogenes, reference values for effusions and bone marrow aspirates, laboratory handling of samples, and how to carry out certain diagnostics. The book: Includes cha

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Book SynopsisFrom Ayurvedic texts to botanical medicines to genomics, ideas and expertise about veterinary healing have circulated between cultures through travel, trade, and conflict. In this broad-ranging and accessible study spanning 400 years of history, Susan D. Jones and Peter A. Koolmees present the first global history of veterinary medicine and animal healing. Drawing on inter-disciplinary and multi-disciplinary perspectives, this book addresses how attitudes toward animals, disease causation theories, wars, problems of food insecurity and the professionalization and spread of European veterinary education have shaped new domains for animal healing, such as preventive medicine in intensive animal agriculture and the need for veterinarians specializing in zoo animals, wildlife, and pets. It concludes by considering the politicization of animal protection, changes in the global veterinary workforce, and concerns about disease and climate change. As mediators between humans and animals, veterTrade Review'Captivating and unique! A complete account of the history of healing animals, the fight against their diseases, and how the veterinary profession has evolved across cultures and continents shaping food systems and our relations with animals today.' Katinka de Balogh, Food and Agriculture Organization of the United Nations'This book promised to fill the gap of the missing text book on the history of veterinary medicine. It does! Summaries and questions provoke students to think critically. However, this book is more than only a textbook. This is the profession I've dedicated most of my professional life to as students will do overtime. The story starts with the animal healers in ancient times and goes up to the regulated veterinary professional today. The authors outline a little bit of our future. A Concise History of Veterinary Medicine will be the perfect birthday present for all my veterinary friends.' Rens van Dobbenburgh, President Federation of Veterinarians of Europe'An outstanding synthesis of global developments in the history of animal healing. Informed by the study of human-animal relationships, and drawing on the latest research findings, A Concise History of Veterinary Medicine is essential reading for vets and historians alike.' Abigail Woods, University of Lincoln, President of the World Association for the History of Veterinary MedicineTable of ContentsIntroduction: human-animal relationships and the need for veterinary medicine; 1. Animal healing in sacred societies, 1500-1700; 2. Animal healing in trade and conquest, 1700-1850s; 3. Formal education for animal healing: from riding schools to veterinary schools, 1700-1850; 4. Veterinary institutions and animal plagues, 1800-1900; 5. Veterinary medicine in war and peace, 1900-1960; 6. Food, animals and veterinary care in a changing world, 1960-2000; 7. Veterinary medicine and animal health, 2000-2020; Epilogue: veterinary medicine in the postmodern world.

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Book SynopsisCompanion Animal Ethics explores the important ethical questions and problems that arise as a result of humans keeping animals as companions.Trade Review"This book provides ample food for thought for anyone involved in the animal sector to engage in reflection of their views by clearly working through important ethical questions commonly encountered in companion animal interaction and medicine in particular. It would make a valuable contribution to any practising veterinarian's library, and I would even suggest it to be essential reading for many." (Veterinary Record, 2016)Table of ContentsForeword vii Acknowledgements ix Introduction 1 1 History of Companion Animals and the Companion Animal Sector 8 2 The Development and Role of the Veterinary and Other Professions in Relation to Companion Animals 24 3 Human Attachment to Companion Animals 41 4 Companion Animal Welfare 58 5 Theories of Companion Animal Ethics 73 6 Breeding and Acquiring Companion Animals 89 7 Selective Breeding 103 8 Feeding and the Problem of Obesity 117 9 Companion Animal Training and Behavioural Problems 132 10 Routine Neutering of Companion Animals 150 11 Performing Convenience Surgery: Tail Docking, Ear Cropping, Debarking and Declawing 169 12 Treating Sick Animals and End-of-Life Issues 186 13 Unwanted and Unowned Companion Animals 201 14 Ethics and Broader Impacts of Companion Animals 217 15 Other Companions 235 16 Companion Animals and the Future 252 Index 269

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Book SynopsisTrade Review"Throughout this superbly illustrated textbook, the authors use a combination of histology, gross specimens, and many clinical examples to describe ocular diseases and their underlying pathophysiology...Overall, this book is a valuable and fairly priced resource for veterinary students, veterinarians, and pathologists." JAVMA, MAR 15, 2019, VOL 254, NO. 6Table of ContentsForeword xiii Acknowledgements xv 1 Fixation and processing of ocular tissues 1 Fixatives 1 Fixation and sectioning artifacts 2 Fixation techniques 3 Trimming the fixed globe 5 Electron microscopy 13 References 14 2 General pathology of the eye 15 Adaptations characterized by changes in cell size, number, or appearance 15 Neoplasia 19 Nomenclature 23 Distinguishing benign from malignant 25 Prognostication 27 Unsuccessful adaptation: cellular degeneration, necrosis, and apoptosis 27 Calcification, pigmentation, and cystic change 30 Ocular inflammation 32 Ocular manifestations of acute inflammation 34 Chronic inflammation 39 Ocular manifestations of chronic inflammation 39 Immune privilege 41 Lymphocytic–plasmacytic endophthalmitis 42 The sequelae of intraocular inflammation and other injuries 43 Limited regenerative ability 43 Susceptibility to scarring 43 Further reading 46 3 Congenital anomalies 49 Introduction 49 Defective organogenesis 50 Defective early organogenesis 50 Anophthalmos and cystic globe 53 Anophthalmos and microphthalmos 54 Cyclopia and synophthalmos 56 Congenital anomalies of lens 56 Congenital retinal nonattachment 63 Aniridia – iridal hypoplasia or aplasia 63 Coloboma 63 Defective later organogenesis 64 Neurectodermal defects 64 Multifocal retinopathies 71 Multiple ocular anomalies (MOA) in Rocky Mountain horses 71 Anomalies of surface ectodermal origin that develop during later organogenesis 73 Congenital adnexal cysts 73 Dermoids 73 Defects of neural crest migration and mesenchymal differentiation that develop in later organogenesis 73 Congenital corneal disease 73 Congenital disorders of neurocrest and mesenchymal tissues that manifest in the uvea during later organogenesis 74 Persistent pupillary membranes (PPMs) 74 Congenital glaucoma 75 Uveal hypoplasia 78 Collie eye anomaly (CEA) and related defects 78 Persistence of embryonic vasculature 81 References 83 4 Histopathology of ocular trauma 89 Perforating and penetrating wounds of the globe and ocular tissues 89 Perforating wounds of the globe 89 Traumatic intraocular hemorrhage 89 Expulsive subchoroidal hemorrhage 90 Sequelae of intraocular hemorrhage 90 Posttraumatic inflammation 95 Phacoclastic endophthalmitis and traumatic cataract 95 Infectious endophthalmitis 95 Trauma to individual ocular tissues 95 Orbit and optic nerve 95 Cornea/sclera 95 Uvea 100 Lens 101 Vitreous and retina 101 Globe as a whole 101 Reaction to foreign materials 101 Complications of ocular surgery 102 Chemical and thermal burns 102 Effects of radiant energy 103 References 103 5 Diseases of the eyelid, conjunctiva, lacrimal, and nasolacrimal systems 105 Eyelids 105 Structural disorders 105 Dermoids 105 Hamartomas 105 Subconjunctival fat prolapse 105 Entropion, ectropion, and medial canthal pocket syndrome 105 Distichiasis, districhiasis, and ectopic cilia 106 Inflammatory disease 108 Pyogranulomatous (granulomatous) blepharitis 108 Juvenile sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) 110 Chalazion 110 Medial canthal erosion syndrome 111 Proliferative pox virus blepharitis in birds 111 Parasitic eyelid disorders 111 Demodicosis 111 Cnemidocoptes pilae (scaly beak) infestation of avian species 113 Eyelid tumors and neoplasms 113 Cystic apocrine hyperplasia (hidrocystomas, sudoriferous cysts, and apocrine cysts) 113 Granular cell tumor 113 Meibomian (tarsal gland) adenoma 115 Melanocytoma and melanoma 115 Histiocytoma 118 Mast cell tumor 118 Peripheral nerve sheath tumors 118 Equine sarcoid 121 Squamous cell carcinoma 122 Diseases of the conjunctiva 123 General pathology of the conjunctiva 124 Congenital conjunctival abnormalities 124 Infectious conjunctivitis 126 Herpesvirus 126 Chlamydophila (chlamydia) 126 Rickettsia rickettsi 126 Moraxella bovis 126 Parasitic conjunctivitis 126 Noninfectious inflammatory disease 127 Episclerokerataconjunctivitis 127 Lipogranulomatous conjunctivitis of cats 127 Eosinophilic conjunctivitis 128 Miscellaneous conjunctival disorders 128 Conjunctival overgrowth in rabbits (pseudopterygium) 128 Membranous (ligneous) conjunctivitis 129 Conjunctival neoplasms 129 Conjunctival lymphoma 129 Conjunctival mast cell tumors 130 Conjunctival melanoma and melanocytoma 130 Viral papillomas 133 Conjunctiva squamous papilloma 133 Conjunctival squamous cell carcinoma 133 Conjunctival vascular neoplasia 133 Miscellaneous neoplasms of the third eyelid 133 Lacrimal and nasolacrimal disorders 136 Neoplasms of the gland of the third eyelid 136 Prolapsed gland of the third eyelid 138 Keratoconjunctivitis sicca (KCS) 138 Dacryops and canaliculops 138 References 138 6 Diseases of the cornea 143 Corneal wound healing 143 Epithelial wound healing 143 Stromal wound healing 147 Endothelial wound healing 149 Epithelial and fibrous ingrowth 151 Healing of corneal grafts 152 Nonspecific corneal responses to insult 152 Corneal vascularization 152 Corneal pigmentation 154 Corneal edema 154 Keratitis 154 Epithelial alterations of keratitis 154 Stromal alterations of keratitis 156 Endothelialitis 158 Specific inflammatory corneal disease 159 Immune‐mediated nonulcerative keratitis 159 Immune‐mediated ulcerative keratitis 159 Superficial punctate keratitis (punctate erosive corneal dystrophy) 159 Chronic superficial keratitis (pannus) 159 Eosinophilic keratitis 161 Miscellaneous corneal disorders: corneal sequestrum, indolent corneal ulceration, corneal dystrophy, corneal lipid infiltrates, and corneal degeneration 161 Corneal sequestrum 161 Indolent ulceration (boxer ulcer, spontaneous corneal epithelial defects) 164 Corneal dystrophies, corneal lipid infiltrates, and corneal calcific/lipid degeneration 165 Miscellaneous corneal disease 167 Corneal neoplasia 172 References 177 7 Diseases of the episclera and sclera 181 Primary episcleral and scleral inflammatory disorders: a brief introduction 181 Secondary scleritis 181 Scleral neoplasia 182 Limbal melanocytoma 184 Episcleritis (episclerokeratitis, episclerokeratoconjunctivitis) 185 Scleritis and necrotizing scleritis a continuum or separate conditions? 189 Non‐necrotizing scleritis 193 Necrotizing scleritis 195 Parasitic episcleral disease (onchocerca vulpis/lienalis) 195 References 196 8 Histologic manifestations of disorders of the uvea 197 Normal aging changes 203 Degenerative diseases of the uvea 205 Uveal atrophy 205 Uveal cysts 205 Cystoid degeneration of the pars plana ciliary epithelium 205 Pre‐iridal fibrovascular membranes (PIFMs) 208 Heterotopic bony metaplasia of the ciliary body in guinea pigs 208 Uveitis 210 The nomenclature of uveitis 210 The intraocular events of uveitis 210 The etiologic implications of inflammatory exudates 216 Immune privilege 218 Consequences of uveitis 218 Histologic basis of the common infectious, idiopathic, and immune‐mediated uveitis syndromes in domestic animals 221 Lens‐induced uveitis 221 Phacolytic uveitis 223 Phacoclastic uveitis 224 Equine recurrent uveitis 227 Feline lymphocytic–plasmacytic uveitis 231 Pigmentary uveitis/pigmentary glaucoma of dogs 231 Equine heterochromic iridocyclitis with secondary keratitis 233 Vogt–Koyanagi–Harada‐like or uveodermatologic syndrome in dogs 233 Uveal xanthogranuloma in miniature schnauzers 235 Uveitis associated with specific infectious agents 235 Viruses 235 Feline infectious peritonitis 235 Canine adenovirus‐associated uveitis 238 Canine distemper virus‐associated uveitis 239 Bovine malignant catarrhal fever (MCF)‐associated uveitis 239 Bovine viral diarrhea mucosal disease‐associated uveitis 239 Ovine bluetongue 239 Equine viral arteritis (EVA)‐associated uveitis 239 West Nile‐associated avian uveitis 239 Hog cholera 239 Bacteria 240 Fungi 241 Other infectious causes for endophthalmitis 245 Algal endophthalmitis 246 Protozoan endophthalmitis 246 Metazoan parasitic uveitis 246 References 250 9 Histologic basis of glaucoma 255 Introduction 255 The gross, subgross, and histologic lesions of elevated IOP 255 Retinal changes 257 Optic nerve changes 262 Classification of canine glaucoma and introduction to open and closed angles 266 Congenital glaucoma 267 Primary glaucoma 270 Open angle glaucoma of beagle dogs 274 Primary (congenital) glaucoma in New Zealand white rabbit 274 Secondary glaucoma 274 Pre‐iridal Fibrovascular Membrane 274 Posterior Synechia with Pupillary Block 275 Vitreous degeneration, syneresis, and anterior chamber prolapse 275 Trabecular obstruction by tumor 278 Other causes of secondary glaucoma in dogs 278 Glaucoma in cats 283 Glaucoma in horses 284 References 286 10 Histologic manifestations of acquired and inherited diseases of the lens 289 Embryology and anatomy of the lens 289 Physiology of the lens 292 Pathology of the lens 292 Aging changes 294 Cataract 294 The classification of cataracts 294 The histopathology of cataract 294 The pathogenesis of cataracts 299 Etiologies of cataract 299 Lens luxation 302 Inherited lens zonular dysplasia 303 References 305 11 Acquired diseases of the vitreous 307 Primary disorders of the vitreous 310 Vitreous degeneration 310 Asteroid hyalosis 315 Posterior vitreous detachment 315 Synchisis scintillans 315 Uveal and neuroectodermal pigment and cysts within the vitreous and incidental parasitic encounters 317 Neovascularization 317 Conditions with secondary vitreous involvement 317 Vitritis 317 Vitreous hemorrhage 319 References 322 12 Histologic manifestations of retinal disease 325 Introduction 325 Retinal diseases by histologic pattern 328 Retinal atrophy 329 Inner retinal atrophies 329 The pathogenesis of retinal degeneration secondary to glaucoma 329 Retinal atrophy secondary to non‐glaucomatous optic nerve injury and vascular disease 335 Optic nerve hypoplasia/aplasia 336 Outer retinal (photoreceptor) atrophies 336 Inherited photoreceptor dysplasias and degenerations 336 Retinal detachment 340 Toxic and nutritional retinopathies 346 Fluoroquinolone‐induced retinal degeneration 346 Vitamin A deficiency 347 Vitamin E deficiency 347 Taurine deficiency 347 Light‐induced retinal degeneration 347 Sudden acquired retinal degeneration (SARD) and immune mediated retinopathy (IMR) of dogs 352 Diseases targeting the retinal pigment epithelium 352 Retinal pigment epithelial dystrophy (central progressive retinal atrophy) 352 Hereditary retinal pigment epithelial disorders (congenital stationary night blindness of briard dogs, multifocal retinopathies) 352 Canine multifocal retinopathy 354 Retinal pigment epithelial dysplasia in the royal college of surgeons rat 354 Localized chorioretinal atrophy in rats 354 Retinitis 354 Bystander retinitis 356 Retinitis as a manifestation of neurologic disease 356 Histophilus somni (formerly Hemophilus somnus) infection in cattle 356 Canine distemper 356 Retinal lesions reflecting noninfectious systemic disease 357 Retinal lesions of systemic hypertension 357 Retinal lesions resulting from inborn errors in the intermediary metabolism (lysosomal storage diseases and others) 357 Retinal injury from thermal energy 358 Retinal neoplasms 358 Medullopitheliomas 360 Retinoblastoma 360 References 360 13 Acquired diseases of the optic nerve 367 Intraocular disorders with associated optic neuropathy 367 Glaucomatous optic neuropathy 367 Endophthalmitis and ascending optic neuritis 372 Canine distemper optic neuritis 372 Orbital disorders that affect the optic nerve 372 Proptotic optic neuropathy 372 Orbital cellulitis/abscess with optic nerve sepsis 372 CNS conditions that affect the optic nerve 372 Optic nerve disorders 376 Granulomatous meningoencephalitis 376 Unilateral granulomatous optic neuritis 376 Optic neuropathy in horses 376 Feline optic neuropathies 376 Other causes of optic neuritis 378 Toxic optic neuropathy 378 Vitamin A deficiency 379 Primary optic nerve neoplasms 381 Meningioma 381 Optic nerve gliomas 382 Peripapillary medulloepitheliomas 382 Lymphosarcoma and other metastatic neoplasms 382 References 384 14 Acquired diseases of the orbit 387 Introduction 387 Inflammatory disease 387 Extraocular myositis 388 Lacrimal adenitis 389 Orbital trauma/hematoma 390 Zygomatic sialocoele 391 Orbital cysts and post‐enucleation orbital mucocoeles 393 Parasitic orbital disease 396 Orbital neoplasia 396 Multilobular tumor of bone (multilobular osteochondroma) 398 Primary orbital osteoma and osteosarcoma 402 Lacrimal adenoma and adenocarcinoma 404 Harderian gland adenomas and adenocarcinomas 404 Rhabdomyosarcoma 404 Orbital myofibroblastic sarcoma 404 Vascular anomalies 406 References 406 15 Intraocular neoplasia 409 Non‐neoplastic hyperpigmented lesions 410 Benign melanocytic neoplasia 410 Uveal melanocytoma 410 Uveal melanocytosis (melanosis) 415 Malignant uveal melanomas 415 Canine and feline uveal malignant melanoma 415 Diffuse iris melanoma of cats 417 Iris and ciliary epithelial neoplasia 422 Medulloepithelioma and retinoblastoma (primitive neuroectodermal tumors) 426 Primary ocular sarcomas of cats and rabbits 428 Schwannomas of blue eyed dogs 430 Osteosarcoma and chondrosarcoma 430 Miscellaneous primary intraocular tumors 432 Metastatic uveal neoplasia 433 Lymphosarcoma 433 Secondary intraocular neoplastic extension from primary nasal and orbital and adnexal neoplasms 435 References 436 Index 443

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Book SynopsisZoonotic Tuberculosis: Mycobacterium bovis and Other Pathogenic Mycobacteria, Third Edition is a comprehensive review of the state of the art in the control and elimination of infections caused by Mycobacterium tuberculosis complex in animals and humans. This update to the most complete and current reference available on Mycobacterium bovis includes new coverage of the latest molecular techniques; more information on human infection and One Health; updates to the information on the International Union Against Tuberculosis and Lung Disease (IUATLD), the World Health Organization (WHO), Pan American Health Organization (PAHO), and the United States Department of Agriculture's (USDA) National Tuberculosis Eradication Program; and coverage of additional Africancountries. The Third Edition upholds the book's reputation as a truly global resource on M. bovis. Written by an international list of tuberculosis experts, chapters cover the status of tuberculoTrade Review“The third edition complements the previous editions and will be a useful text for readers interested in both human and animal tuberculosis.” (Journal of the American Veterinary Medical Association, 15 September 2014) “Zoonotic Tuberculosis’ is a superb text and should be placed on the shelf alongside the previous editions for anyone wanting to know more about the global management of tuberculosis.” (Veterinary Record, 21 June 2014)Table of ContentsContributors ix Preface xv 1 Tuberculosis in animals and humans: An introduction 3 Charles O. Thoen, Philip A. LoBue, and Donald A. Enarson 2 One Health approach for preventing and controlling tuberculosis in animals and humans 9 John B. Kaneene, Bruce Kaplan, James H. Steele, and Charles O. Thoen 3 Public health significance of zoonotic tuberculosis caused by the Mycobacterium tuberculosis complex 21 Adam J. Langer and Philip A. LoBue 4 Mycobacterium bovis infection in humans and animals with an emphasis on countries in Central and South America 35 Isabel N. de Kantor, Pedro M. Torres, Eliana Roxo, Alfredo Garin, Luis A. Paredes Noack, María D. Sequeira, María Susana Imaz, Nora Morcillo, and María Alice da Silva Telles 5 Pathogenesis of tuberculosis caused by Mycobacterium bovis 51 Charles O. Thoen and Raúl G. Barletta 6 Epidemiology of Mycobacterium bovis 63 Julian A. Drewe, Dirk U. Pfeiffer, and John B. Kaneene 7 Molecular epidemiology of Mycobacterium bovis 79 Julian A. Drewe and Noel H. Smith 8 New and current approaches for isolation, identification, and genotyping of Mycobacterium bovis 89 Suelee Robbe-Austerman and Claude Turcotte 9 Tuberculosis in animals in South Africa 99 Nick Kriek 10 Status and control of bovine tuberculosis in Ethiopia 109 Asseged Bogale, Berhanu Tameru, and Tsegaye Habtemariam 11 Distribution, public health significance, and control status of bovine tuberculosis caused by Mycobacterium bovis in Uganda 133 David Nganwa and Asseged Bogale 12 Bovine tuberculosis: Epidemiology, zoonotic transmission, activities, and challenges toward its control in Nigeria 149 Simeon I.B. Cadmus and F. Olalekan Ayanwale 13 Factors contributing to the transmission of bovine tuberculosis caused by Mycobacterium bovis and its control status in Sudan 159 Ehsan Abdalla and David Nganwa 14 Overview of bovine tuberculosis in Ghana 175 Gregory Banayah Mwinyelle and Andy Alhassan 15 Status and control of tuberculosis in animals in Pakistan 181 M. Tariq Javed 16 Zoonotic tuberculosis in humans, elephants, and other animals in Nepal 191 Mahesh Bhandari and Charles O. Thoen 17 Zoonotic tuberculosis in India 197 Rishendra Verma 18 An overview of Mycobacterium bovis infections in domestic and wild animals in Korea 203 Han Sang Yoo and Kyoungjin J. Yoon 19 Mycobacterium bovis infection and control in China 213 Aizhen Guo, Yingyu Chen, and Huanchun Chen 20 Zoonotic tuberculosis in Australia and New Zealand 221 Graham Nugent and Debra V. Cousins 21 Bovine tuberculosis eradication in the United States: A century of progress 235 Alecia Larew Naugle, Mark Schoenbaum, C. William Hench, Owen L. Henderson, and Jack Shere 22 The occurrence of M. bovis cases in U.S. cattle, 2001–2011 253 Katie Portacci, Jason Lombard, Mark Schoenbaum, Kathleen Orloski, and Mark Camacho 23 The importance of M. bovis infection in cervids on the eradication of bovine tuberculosis in the United States 263 Michael J. Gilsdorf and John B. Kaneene 24 Evaluation of antemortem diagnostic tests for detecting bovine tuberculosis infection in the United States 277 Mark Schoenbaum, María Celia Antognoli, and Kathleen Orloski 25 Canada’s bovine tuberculosis eradication program: Past and present 287 Noel Harrington, Krista Howden, and Claude Turcotte 26 Bovine tuberculosis eradication program in Mexico 291 Alejandro Perera Ortiz, José Alfredo Gutiérrez-Reyes, Estela Flores Velázquez, Guillermo Agustín Reyes Escalona, and Eli Tonatiuh Selva Hernández 27 Epidemiology of bovine tuberculosis in the Republic of Serbia with a brief overview of the current epidemiological situation in the region 309 Dejan Krnjaic, Budimir Plavsic, and Slavoljub Stanojevic 28 The impact of an integrated wildlife and bovine tuberculosis eradication program in Ireland 323 Michael Sheridan, Margaret Good, Simon J. More, and Eamonn Gormley 29 Bovine tuberculosis eradication in France 341 María Laura Boschiroli and Jean-Jacques Bénet 30 Animal tuberculosis in Spain: A multihost system 349 Christian Gortazar and Mariana Boadella 31 Tuberculosis eradication in Italy 357 Laura Chiavacci, Alessandro Dondo, Maria Goria, Giuliana Moda, Luigi Ruocco, Patrizia Vignetta, and Simona Zoppi 32 Status of bovine tuberculosis control in countries of Central Europe and countries of the former Soviet Union 369 Ivo Pavlik 33 Zoonotic tuberculosis in nonhuman primates 383 Pat A. Frost, Paul P. Calle, Hilton Klein, and Charles O. Thoen Index 399

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Book SynopsisEquine Neurology, Second Edition provides a fully updated new edition of the only equine-specific neurology book, with comprehensive, clinically oriented information.Trade Review“I thoroughly recommend it and would not be without it now.” (Veterinary Record, 14 November 2015) “The second edition of Equine Neurologyedited by Martin Furr and Stephen Reed is a valuable reference for veterinary students, general practitioners, and specialists.” (Journal of the American Veterinary Medical Association, 15 September 2015)Table of ContentsContributors List vii Preface ix Video Clips Demonstrating Clinical Signs x Section 1: Foundations of Clinical Neurology 1 Overview of Neuroanatomy 3 Caroline Hahn and Jerry Masty 2 Cerebrospinal Fluid and the Blood–Brain Barrier 21 Martin Furr 3 Immunology of the Central Nervous System 36 Martin Furr 4 Pharmaceutical Considerations for Treatment of Central Nervous System Disease 46 Véronique A. Lacombe and Martin Furr 5 Fundamental Neurophysiology 58 Craig Johnson and Caroline Hahn Section 2: Clinical Equine Neurology 6 Examination of the Nervous System 67 Martin Furr and Stephen Reed 7 Differential Diagnosis and Management of Horses with Seizures or Alterations in Consciousness 79 Véronique A. Lacombe and Martin Furr 8 Differential Diagnosis of Equine Spinal Ataxia 93 Martin Furr 9 Differential Diagnosis and Management of Cranial Nerve Abnormalities 99 Robert J. MacKay 10 Sleep and Sleep Disorders in Horses 123 Joseph J. Bertone 11 Headshaking 130 Monica Aleman and Kirstie Pickles 12 Differential Diagnosis of Urinary Incontinence and Cauda Equina Syndrome 139 Melissa Hines 13 Differential Diagnosis of Muscle Tremor and Paresis 149 Amy L. Johnson 14 Electrodiagnostic Evaluation of the Nervous System 157 George M. Strain, Frank Andrews and Veronique A. Lacombe 15 Anesthetic Considerations for Horses with Neurologic Disorders 184 Adriana G. Silva 16 The Basics of Equine Neuropathology 191 Fabio Del Piero and John L. Robertson 17 Diagnostic Imaging of the Equine Nervous System 215 Katherine Garrett Section 3: Specific Disease Syndromes 18 Equid Herpesvirus‐Associated Myeloencephalopathy 225 Lutz S. Goehring 19 Mosquito‐Borne Infections Affecting the Central Nervous System 233 Maureen T. Long 20 Contagious Neurological Diseases 262 Maureen T. Long 21 Bacterial Infections of the Central Nervous System 273 Martin Furr 22 Equine Protozoal Myeloencephalitis 285 Martin Furr and Daniel K. Howe 23 Parasitic Infections of the Central Nervous System 306 Martin Furr 24 Miscellaneous Infections of the Central Nervous System 314 Martin Furr 25 Disorders Associated with Clostridial Neurotoxins: Botulism and Tetanus 319 Martin Furr 26 Neurodegenerative Disorders 328 Robert J. MacKay 27 Equine Hepatic Encephalopathy 343 Tom Divers 28 Cervical Vertebral Stenotic Myelopathy 349 Amy L. Johnson and Stephen Reed 29 Electrolyte Abnormalities and Neurologic Dysfunction in Horses 368 Ramiro E. Toribio 30 Cervical Articular Process Disease Fractures and Other Axial Skeletal Disorders 386 Richard Hepburn 31 Congenital Malformation of the Nervous System 401 Martin Furr 32 Central Nervous System Trauma 406 Yvette S. Nout‐Lomas 33 Disorders of the Peripheral Nervous System 429 Martin Furr 34 Equine Neurotoxic Agents and Conditions 437 Martin Furr 35 Neonatal Encephalopathy and Related Conditions 455 Martin Furr 36 Miscellaneous Movement Disorders 465 Caroline Hahn 37 Stereotypic and Behavior Disorders 472 Carissa L. Wickens and Katherine A. Houpt 38 Miscellaneous Conditions 484 Martin Furr Index 488

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Book SynopsisEquine Clinical Immunology offers comprehensive information on equine immunological disorders.Table of ContentsContributors, ix Preface, xi 1 The Immune System, 1M. Julia B. Felippe 1.1 Definition, 1 1.2 The organs of the immune system, 1 1.3 The immune cells and soluble molecules, 2 1.4 B and T cell activation in lymphoid tissues, 6 1.5 When the immune response goes wrong, 9 References, 10 2 The Immune System of the Young Horse, 11Rebecca L. Tallmadge 2.1 Definition, 11 2.2 Equine immune system development, 11 2.3 Unique susceptibilities and disorders of young horses, 16 2.4 Vaccinology teaches about neonatal immunity, 18 References, 18 3 The Immune System of the Older Horse, 23Amanda A. Adams and David W. Horohov 3.1 Definition, 23 3.2 Clinical conditions associated with aging, 23 3.3 Immunosenescence and vaccination, 23 3.4 Nutrition in enhancing immunity in the old horse, 26 3.5 Conclusion, 27 References, 27 4 Anaphylaxis, 31Rolfe M. Radcliffe 4.1 Definition, 31 4.2 Signalment and clinical signs, 31 4.3 Immunologic mechanisms and etiologic associations, 32 4.4 Diagnostics, 33 4.5 Treatment, 34 4.6 Prevention, 36 4.7 Prognosis and clinical outcomes, 37 References, 37 5 Allergy, 39Bettina Wagner 5.1 Definition, 39 5.2 Culicoides hypersensitivity, 39 5.3 Urticaria, 43 5.4 Recurrent airway obstruction, 44 References, 44 6 Immune-Mediated Cytopenias, 47Thomas J. Divers 6.1 Definition, 47 6.2 Immune-mediated hemolytic anemia, 47 6.3 Immune-mediated thrombocytopenia, 50 6.4 Immune-mediated neutropenia, 53 References, 54 7 Bullous Diseases of the Skin and Mucosa, 55Jeanine Peters-Kennedy and Rebecca E. Ruby 7.1 Definition, 55 7.2 Immune-mediated bullous dermatoses, 55 7.3 Pemphigus complex, 57 7.4 Cutaneous adverse drug reactions, 61 7.5 Erythema multiforme, 62 7.6 Lupus erythematosus, 64 References, 65 8 Serum Sickness, 69Lais R.R. Costa 8.1 Definition, 69 8.2 Signalment and clinical signs, 69 8.3 Immunologic mechanisms and etiologic associations, 69 8.4 Diagnostics, 71 8.5 Treatment and prevention, 71 References, 72 9 Vasculitis, 73James S. W. Prutton and Nicola Pusterla 9.1 Definition, 73 9.2 Signalment and clinical signs, 73 9.3 Immunologic mechanisms and etiologic associations, 73 9.4 Diagnostics, 75 9.5 Treatment, 75 9.6 Thrombophlebitis, 75 9.7 Pastern and cannon leukocytoclastic vasculitis, 76 9.8 Drug-induced vasculitis, 76 9.9 Photo-activated vasculitis (photodynamic drugs), 77 9.10 Strongylus vulgaris, 77 9.11 Equine granulocytic anaplasmosis, 77 9.12 Equine viral arteritis, 78 9.13 Equine herpesvirus-1, 78 9.14 African horse sickness, 78 References, 79 10 Purpura Hemorrhagica, 83Laszlo M. Hunyadi and Nicola Pusterla 10.1 Definition, 83 10.2 Signalment and clinical signs, 83 10.3 Immunologic mechanisms and etiologic associations, 83 10.4 Diagnostics, 84 10.5 Treatment and prevention, 85 References, 86 11 Glomerulonephritis, 87M. Julia B. Felippe 11.1 Definition, 87 11.2 Signalment and clinical signs, 87 11.3 Immunologic mechanisms and etiologic associations, 87 11.4 Diagnostics, 88 11.5 Treatment and prognosis, 88 References, 88 12 Inflammatory and Immune-Mediated Muscle Disorders, 91Sian Durward-Akhurst and Stephanie J. Valberg 12.1 Definition, 91 12.2 Infarctive purpura hemorrhagica, 91 12.3 Rhabdomyolysis associated with Streptococcus equi, 93 12.4 Immune-mediated myositis in Quarter Horse-related breeds, 94 12.5 Systemic calcinosis, 96 12.6 Uncharacterized immune-mediated and inflammatory myopathies, 97 12.7 Sarcocystis myositis, 97 References, 98 13 Granulomatous Diseases, 101Lais R.R. Costa 13.1 Definition, 101 13.2 Signalment and clinical signs, 101 13.3 Immunologic mechanisms and etiologic associations, 101 13.4 Diagnostics, 104 13.5 Treatment and prevention, 105 13.6 Types of cell-mediated hypersensitivity reactions, 105 References, 110 14 Chronic Inflammatory Bowel Disease, 113Gillian A. Perkins 14.1 Definition, 113 14.2 Signalment and clinical signs, 113 14.3 Immunologic mechanisms and etiologic associations, 113 14.4 Diagnostics, 115 14.5 Treatment and prognosis, 116 References, 117 15 Recurrent Uveitis, 121Brian C. Gilger 15.1 Definition, 121 15.2 Signalment and clinical signs, 121 15.3 Immunologic mechanisms and etiologic associations, 121 15.4 Diagnostics, 123 15.5 Treatment and prevention, 124 15.6 Prognosis and clinical outcomes, 124 References, 125 16 Recurrent Airway Obstruction and Summer Pasture-Associated Obstructive Pulmonary Disease, 127Michela Bullone and Jean-Pierre Lavoie 16.1 Definition, 127 16.2 Signalment and clinical signs, 127 16.3 Immunologic mechanisms and etiologic associations, 128 16.4 Diagnostics, 134 16.5 Treatments and prevention, 136 References, 137 17 Inflammatory Airway Disease, 145Mathilde Leclère and Jean-Pierre Lavoie 17.1 Definition, 145 17.2 Signalment and clinical signs, 145 17.3 Immunologic mechanisms and etiologic associations, 145 17.4 Types of bronchoalveolar lavage fluid inflammation and cytokine profile, 147 17.5 Links between IAD and heaves, 148 17.6 Links between IAD and EIPH, 148 17.7 Diagnostics, 148 17.8 Treatment and prevention, 149 17.9 Prognosis and clinical outcomes, 150 References, 150 18 Inflammation, Endotoxemia and Systemic Inflammatory Response Syndrome, 153Erin L. McConachie and Kelsey A. Hart 18.1 Definition, 153 18.2 Signalment and clinical signs, 154 18.3 Immunologic mechanisms and etiologic associations, 155 18.4 Multi-systemic response triggered by inflammatory mediators, 157 18.5 Diagnostics, 160 18.6 Treatment, 162 18.7 Prognosis and clinical outcome, 166 References, 166 19 Leukemia, 173Tracy Stokol 19.1 Definition, 173 19.2 Classification of leukemias, 173 19.3 Specialized diagnostic techniques for leukemia, 173 19.4 Chronic leukemia, 175 19.5 Acute leukemia, 177 References, 179 20 Lymphoma, 181SallyAnne L. Ness 20.1 Definition, 181 20.2 Signalment and clinical signs, 181 20.3 Forms of equine lymphoma, 182 20.4 Immunologic mechanisms and etiologic associations, 183 20.5 Diagnostics, 183 20.6 Classification of lymphomas, 185 20.7 Prognosis and treatment, 186 20.8 Monitoring, 189 References, 189 21 Immunodeficiencies, 193M. Julia B. Felippe 21.1 Definition, 193 21.2 Classification of immunodeficiencies, 194 References, 202 22 Immunologic Testing, 205M. Julia B. Felippe 22.1 Definition, 205 22.2 Types of immunologic testing, 205 References, 211 23 Non-steroidal Anti-inflammatories, 213Michelle H. Barton 23.1 Definition, 213 23.2 Non-steroidal anti-inflammatory drugs, 213 References, 228 24 Immunosuppressive Therapy, 237M. Julia B. Felippe 24.1 Definition, 237 24.2 Types of immunosuppressive drugs, 237 References, 240 25 Immunomodulators, 243Elizabeth G. Davis 25.1 Definition, 243 25.2 Immunologic mechanisms, 243 25.3 Commercially available immunostimulants for use in horses, 244 References, 249 26 Immunoglobulin Therapy, 251Elizabeth G. Davis 26.1 Definition, 251 26.2 Immunologic mechanisms, 251 References, 254 27 Plasmapheresis, 257Nathan M. Slovis 27.1 Definition, 257 27.2 Methods for preparing plasma products, 257 27.3 Apheresis, 258 27.4 Therapeutic plasmapheresis, 258 27.5 Complications of therapeutic plasmapheresis, 260 References, 260 28 Principles of Vaccination, 263Noah D. Cohen and Angela I. Bordin 28.1 Definition, 263 28.2 Efficacy and effectiveness of vaccines, 263 28.3 Safety of vaccines, 271 28.4 Key knowledge-gaps in equine vaccinology, 273 28.5 Protocols for vaccination, 275 References, 276 29 Types of Vaccines, 279Angela I. Bordin and Noah D. Cohen 29.1 Definition, 279 29.2 Immunologic mechanisms, 279 29.3 Immune responses to vaccination, 282 29.4 Routes of vaccination, 284 29.5 Adjuvants and vaccine delivery systems, 285 29.6 Important diseases with unavailable effective vaccines, 285 References, 286 30 Transplantation Immunology, 289Rebecca L. Tallmadge 30.1 Definition, 289 30.2 Equine MHC genes: genomic organization and variation, 289 30.3 Determining equine MHC haplotypes, 290 30.4 Immunosuppression and engraftment, 291 30.5 Graft rejection, 292 30.6 Current transplantation applications, 293 References, 294 31 Mesenchymal Stem Cell Therapy, 297Gerlinde R. Van de Walle, Catharina De Schauwer and Lisa A. Fortier 31.1 Definition, 297 31.2 Regenerative functions of mesenchymal stem cells, 297 31.3 Immunologic mechanisms and associations, 298 31.4 Sources of equine mesenchymal stem cells, 299 31.5 Characterization of equine mesenchymal stem cells, 300 31.6 Applications of equine mesenchymal stem cells in equine regenerative medicine, 302 References, 306 32 Hematopoietic Stem Cell Transplantation, 311M. Julia B. Felippe 32.1 Definition, 311 32.2 Hematopoietic stem cell sources, 311 32.3 Pre-transplantation conditioning, 313 32.4 Post-transplantation immunosuppression, 313 32.5 Hematopoietic stem cell transplantation in the horse, 313 References, 315 Index, 317

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Book SynopsisAcid-Base and Electrolyte Handbook for Veterinary Technicians provides an easy to understand yet comprehensive approach to acid-base and electrolyte balance.Trade Review"This is an affordable, useful addition to the veterinary acid-base literature and could be used by students or practitioners of veterinary medicine or veterinary technology...The book is written by veterinary technicians for veterinary technicians. It is of high quality and moderate complexity...The editors are to be commended for including a chapter on the strong ion approach to acid-base in veterinary patients. This feature is still lacking in many books, despite the wide scientific acceptance of the strong ion approach. It is often omitted for its mathematical complexity and potential lack of utility, but the author of that chapter does a good job of explaining the easy utility of strong ion difference clinically even if the total strong ion approach remains out of reach practically." (Doody Enterprises 17/03/2017)"Too often, veterinarians expect the veterinary technicians working alongside them to aid in patient care without a complete understanding of the complex pathophysiology of the disease or condition that is affecting the patient. Acid-Base and Electrolyte Handbook for Veterinary Technicians aims to correct this deficiency and hits the mark with only a few caveats"....."This book provides readers the information necessary to achieve that level of understanding. This slim and fairly priced book is perfect for experienced technicians working in a specialty practice, especially an intensive care unit or emergency service, or those seeking specialty certification who want a better understanding of acid-base and electrolyte disorders"......"it is an excellent reference for experienced technicians who wish to expand their knowledge and understanding of common acid-base and electrolyte disturbances" (Reviewed by Anthony Johnson, DVM, DACVECC, Veterinary Information Network, Davis, Calif 15th June 2017 AVMA)Table of ContentsList of Contributors vii Foreword – Stephen P. Dibartola viii About the Companion Website x 1 Introduction to Acid‐Base and Electrolytes 1 Angela Randels‐Thorp, CVT, VTS (ECC, SAIM) and David Liss, RVT, VTS (ECC, SAIM) 2 Disorders of Sodium 13 Angela Chapman, BSc (Hons), RVN, Dip HE CVN, Dip AVN, VTS (ECC) 3 Disorders of Chloride 34 Meri Hall, RVT, LVT, CVT, LATG, VTS (SAIM) 4 Disorders of Potassium 44 Dave Cowan, BA, CVT, VTS (ECC) 5 Disorders of Magnesium 57 Louise O’Dwyer, MBA, BSc (Hons), VTS (Anaesthesia & ECC), DipAVN (Medical & Surgical), RVN 6 Disorders of Phosphorus 66 Louise O’Dwyer, MBA BSc (Hons), VTS (Anaesthesia & ECC), DipAVN (Medical & Surgical), RVN 7 Disorders of Calcium 79 Katherine Howie, RVN, VTS (ECC) 8 Traditional Acid‐Base Physiology and Approach to Blood Gas 102 Jo Woodison, RVT and Angela Randels‐Thorp, CVT, VTS (ECC, SAIM) 9 Metabolic Blood Gas Disorders 121 Eric Zamora‐Moran, MBA, RVT, VTS (Anesthesia & Analgesia) 10 Respiratory Acid‐Base Disorders 136 Paula Plummer, LVT, VTS (ECC, SAIM) 11 Mixed Acid‐Base Disorders 152 Brandee Bean, CVT, VTS (ECC) 12 Strong Ion Approach to Acid‐Base 163 Angela Randels‐Thorp, CVT, VTS (ECC, SAIM) 13 Companion Exotic Animal Electrolyte and Acid‐Base 175 Jody Nugent‐Deal, RVT, VTS (Anesthesia/Analgesia & Clinical Practice‐Exotic Companion Animal) and Stephen Cital, RVT, RLAT, SRA Index 207

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Book SynopsisPractical Physiotherapy for Small Animal Practice provides a concise and accessible introduction to physiotherapy that demonstrates its benefits to both veterinary patients and practitioners.Trade Review“A nice and very practical book for your first steps in physiotherapy.” (Vet Nurses Today, 1 January 2016)One of the highlights in this book is the chapter on therapeutic exercise. The photographs depicting the exercises are also available on the companion website and can be downloaded as handouts, which can be given to clients for use at home. (JAVMA, March 2016)Table of ContentsAbout the authors vii Preface ix Acknowledgements xi About the companion website xiii 1 Introduction 1 2 Anatomy: structure and function of the musculoskeletal system 7 3 Healing 29 4 Clinical examination 47 5 Modalities 69 6 Manual therapies 91 7 Common neurological conditions and their rehabilitation 115 8 Therapeutic exercise 147 9 Splints supports and aids 195 10 Pain 211 11 Treatment protocols 225 12 Setting up a physiotherapy clinic 259 Appendix 1 Nomenclature 279 Appendix 2 Regenerative medicine 281 Appendix 3 Further reading 283 Appendix 4 Useful websites for aids and equipment 285 Index 287

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Book SynopsisClostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases.Table of ContentsList of Contributors xi Preface xvii Section 1: The pathogenic clostridia 1 Taxonomic Relationships among the Clostridia 3 John F. Prescott, Janet I. MacInnes, and Anson K. K. Wu 2 General Physiological and Virulence Properties of the Pathogenic Clostridia 7 Julian I. Rood 3 Brief Description of Animal Pathogenic Clostridia 13 John F. Prescott Section 2: Toxins Produced by the Pathogenic Clostridia 4 Toxins of Histotoxic Clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi, and Clostridium sordellii 23 Michel R. Popoff 5 Toxins of Clostridium perfringens 45 James R. Theoret and Bruce A. McClane 6 Toxins of Clostridium difficile 61 J. Glenn Songer, Ashley E. Harmon, and M. Kevin Keel 7 Clostridium botulinum and Clostridium tetani Neurotoxins 71 Michel R. Popoff Section 3: Clostridial Infections of the Gastrointestinal System 8 Diseases Produced by Clostridium perfringens Type A in Mammalian Species 109 Francisco A. Uzal 9 NetF‐Associated Necrotizing Enteritis of Foals and Canine Hemorrhagic Gastroenteritis 117 Iman Mehdizadeh Gohari, Valeria R. Parreira, and John F. Prescott 10 Necrotic Enteritis of Poultry 123 Kerry K. Cooper and J. Glenn Songer 11 Infections by Clostridium perfringens Type B 139 Francisco A. Uzal and J. Glenn Songer 12 Diseases Produced by Clostridium perfringens Type C 143 Santiago S. Diab 13 Diseases Produced by Clostridium perfringens Type D 157 Francisco A. Uzal, Federico Giannitti, John W. Finnie, and Jorge P. García 14 Infections by Clostridium perfringens Type E 173 J. Glenn Songer 15 Diseases Produced by Clostridium difficile 177 Santiago S. Diab, Francisco A. Uzal, and J. Glenn Songer 16 Disease Caused by Clostridium colinum: Ulcerative Enteritis of Poultry and Other Avian Species 197 John F. Prescott 17 Clostridial Abomasitis 205 John F. Prescott, Paula I. Menzies, and Russell S. Fraser 18 Diseases Produced by Clostridium spiroforme 221 J. Glenn Songer and Francisco A. Uzal Section 4: Clostridial Histotoxic Infections 19 Blackleg 231 Camila C. Abreu and Francisco A. Uzal 20 Gas Gangrene (Malignant Edema) 243 Rodrigo O. S. Silva, Francisco A. Uzal, Carlos A. Oliveira Jr, and Francisco C. F. Lobato 21 Gangrenous Dermatitis in Poultry 255 H. L. Shivaprasad 22 Bacillary Hemoglobinuria 265 Mauricio Navarro, Fernando Dutra Quintela, and Francisco A. Uzal 23 Infectious Necrotic Hepatitis 275 Mauricio Navarro and Francisco A. Uzal 24 Tyzzer’s Disease 281 Karina C. Fresneda and Francisco R. Carvallo Chaigneau Section 5: Clostridial Neurotoxic Infections 25 Tetanus 295 Michel R. Popoff 26 Botulism 303 Caroline Le Maréchal, Cédric Woudstra, and Patrick Fach 27 Diseases Caused by Other Clostridia Producing Neurotoxins 331 John F. Prescott Index 333

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Book SynopsisNon-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of tTrade ReviewIn its first edition, Pathology for Toxicologists edited by Dr Elizabeth McInnes is a much welcomed addition to the basic literature bridging the 2 complementary sciences of pathology and toxicology, specifically within the context of drug, chemical, or device industries. Aimed at the wide spectrum of study personnel supporting investigational and routine toxicity studies, this book provides a broad yet succinct coverage of the bases underlying the generation and interpretation of pathology data and enables a better use, comprehension, and integration of these data into toxicology reports. In its paperback presentation (provided for this review), the book is illustrated and has a good print quality, is concise, portable, and thoroughly referenced. The 6 contributing authors are all adequately qualified and have hands-on experience on the topics they covered; the editor herself contributed with 4 chapters. The book structure is organized into 8 chapters and include an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist’s perspective, and limitations of pathology and animal models.Each chapter begins with a learning objectives section and ends with a comprehensive list of references; a chapter-by-chapter analysis is included below. The book also includes a glossary (always helpful when dealing with pathology terms and acronyms)and an index. In short, this book is a bridging reference between toxicology and pathology, broadly covering the bases of laboratory animal pathology generation, interpretation, and communication, and it should prove useful not only for early career as well as for practicing toxicologists. (International Journal of Toxicology 36:5) ‘The book succinctly covers the general underpinnings of pathology data generation and interpretation, with the honorable goal of facilitating the use, communication, understanding, and integration of pathology data into toxicology reports …Six highly qualified authors contributed with 8 chapters (4 of which were authored by the editor), spanning various themes in pathology data generation and interpretation, including an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist’s perspective, and limitations of pathology and animal models … At the beginning of each chapter, a learning objectives box frames the most important concepts to be attained and, at its conclusion, a comprehensive list of references points the reader to additional information. The book is complete with an index and a glossary (a must-have when working with pathology terminology and acronyms). This textbook is a bridging reference covering the general bases of pathology data generation, interpretation, and communication that early career and practicing toxicologists will find useful.’ (Journal of Toxicologic Pathology, November 2017) 'Pathology for Toxicologists is highly recommended not only for toxicologist, but also for pharmaceutical research, discovery, and development scientists; young anatomic and clinical toxicologic pathologists; academic and diagnostic pathologists; and anatomic and clinical pathology graduate students and residents. Its use will successfully facilitate the interface between toxicologist and toxicologic pathologists. Its perusal by pharmaceutical research and discovery scientists will facilitate their understanding of the technical constraints and regulatory requirements that face toxicologic pathologists and toxicologic pathology laboratories. Its perusal by young anatomic and clinical toxicologic pathologists upon entry into toxicologic pathology will quickly bring them up-to-speed on the complexity of the regulations and constraints under which they will be working. Perusal of the book by toxicologists and study personnel will provide them an insight into the toxicologic pathology world, improving their interfaces and collaborations and facilitating decisions about pathology.' (Veterinary Clinical Pathology, November 2017)Table of ContentsList of Contributors xi Preface xiii 1 An Introduction to Pathology Techniques 1Elizabeth McInnes 1.1 Animal Considerations 2 1.2 Necropsy 2 1.3 Lung Inflation with Fixative 5 1.4 Fixation 5 1.5 Making Glass Slides 6 1.5.1 Trimming 6 1.5.2 Tissue Processing 9 1.5.3 Embedding 9 1.5.4 Microtoming 9 1.5.5 Staining 9 1.5.6 Quality Control 11 1.6 Special Histochemical Stains 12 1.7 Decalcification 13 1.8 Immunohistochemistry 13 1.9 Tissue Crossreactivity Studies 15 1.10 Electron Microscopy 15 1.11 In Situ Hybridisation 16 1.12 Laser Capture Microscopy 16 1.13 Confocal Microscopy 16 1.14 Image Analysis 17 1.15 Digital Imaging 17 1.16 Spermatocyte Analysis 17 1.17 Good Laboratory Practice 17 1.18 Inhalation Studies 18 1.19 Continuous]Infusion Studies 18 1.20 Carcinogenicity 19 1.21 Biologicals 19 1.22 The Pathology Report 20 1.23 Conclusion 20 References 20 2 Recording Pathology Data 23Cheryl L. Scudamore 2.1 What is a Pathology Finding? 24 2.2 Standardisation of Pathology Findings 24 2.2.1 Semiquantitative Analysis 24 2.2.2 Nomenclature/Controlled Terminology 26 2.2.3 Ontological Approach 28 2.3 ‘Inconsistencies’ in Pathology Recording 28 2.3.1 Diagnostic Drift 28 2.3.2 Thresholds 28 2.3.3 Lumping versus Splitting 29 2.4 Blind Review 30 2.5 Historical Control Data: Pros and Cons 30 2.6 The Use of Peer Review in Pathology 32 References 32 3 General Pathology and the Terminology of Basic Pathology 35Elizabeth McInnes 3.1 Cellular Responses to Insults 35 3.2 Inflammation 41 3.3 Circulatory Disturbances 46 3.4 Disorders of Tissue Growth 52 3.5 Tissue Repair and Healing 53 3.6 Neoplasia 54 3.7 Immune System 55 References 57 4 Common Spontaneous and Background Lesions in Laboratory Animals 59Elizabeth McInnes 4.1 Rats 62 4.2 Mice 63 4.3 Dogs 66 4.4 Minipigs 66 4.5 Non]Human Primates 67 4.6 Rabbits 67 4.7 Experimental Procedures 67 4.8 Causes of Death in Rats and Mice 67 4.9 Conclusion 68 References 69 5 Target Organ Pathology 72Elizabeth McInnes 5.1 Skin 72 5.2 Eye 76 5.3 Gastrointestinal Tract 78 5.4 Liver 83 5.5 Respiratory System 85 5.6 Urinary System 89 5.7 Lymphoreticular System 94 5.8 Musculoskeletal System 95 5.9 Cardiovascular System 97 5.10 Endocrine System 99 5.11 Reproductive System 102 5.12 Central and Peripheral Nervous System 104 5.13 Ear 106 References 106 6 Clinical Pathology 112Barbara von Beust 6.1 Clinical Pathology in Study Phases and Good Laboratory Practice 112 6.1.1 Preanalytic Phase: Study Plan 113 6.1.2 Analytic Phase: Data Generation 114 6.1.3 Postanalytic Phase: Data Interpretation and Reporting 114 6.1.4 Good Laboratory Practice 114 6.2 What is Measured in Clinical Pathology? 115 6.2.1 Interference by Haemolysis, Lipaemia and Icterus 116 6.3 Haematology 117 6.3.1 Manual and Automated Techniques in Haematology 118 6.3.2 Haematocrit and Red Blood Cell Mass 119 6.3.3 Blood Cells 120 6.3.4 The Standard Haematology Profile 124 6.3.5 Bone Marrow 125 6.4 Coagulation 125 6.4.1 Standard Coagulation Profile 126 6.4.2 Prothrombin Time 127 6.4.3 Activated Partial Thromboplastin Time 127 6.4.4 Fibrinogen 127 6.5 Clinical Chemistry 127 6.5.1 Metabolites 127 6.5.2 Enzymes 129 6.5.3 Electrolytes and Minerals 129 6.5.4 Standard Chemistry Profiles 130 6.6 Urinalysis 131 6.7 Acute]Phase Proteins 131 6.8 The Biomarker Concept 132 6.9 Reference Intervals 133 6.10 Instrumentation, Validation and Quality Control 133 6.11 Data Analysis and Interpretation 134 6.12 Reporting 135 6.13 Food Consumption and Body Weight (Gain) 136 6.14 Organ Weights 136 6.15 Examples of Typical Clinical Pathology Profile Changes in Toxicologic Clinical Pathology 136 6.15.1 Reduced Red Blood Cell Mass due to Chronic Disease 138 6.15.2 Stress Response 139 6.15.3 Reduced Red Blood Cell Mass due to Excessive Blood Sampling 139 6.15.4 Common Artefacts 139 6.16 Microsampling 140 6.17 Conclusion 141 Acknowledgments 141 References 141 7 Adversity: A Pathologist’s Perspective 145Bhanu Singh 7.1 LOAEL, NOEL and NOAEL: Definition 146 7.2 Adversity 147 7.3 Determining Adversity using Pathology Findings: Factors to Consider 149 7.3.1 Severity 149 7.3.2 Functional Effect 1507.3.3 Primary versus Secondary Effects 151 7.3.4 Physiological Adaptability 152 7.3.5 Reversibility of the Lesion 152 7.3.6 Pharmacological Effect 153 7.4 Communicating NOAEL in Toxicity Studies 153 7.5 Conclusion 154 References 154 8 Limitations of Pathology and Animal Models 157Natasha Neef 8.1 Limitations of In Vivo Animal Models 157 8.1.1 Traditional Laboratory Species Used as General Toxicology Models 157 8.1.2 The Test Article May Not have Sufficient Pharmacological Activity in Routine Toxicology Species 158 8.1.3 The Model May Not Identify Hazards Related to Causation or Exacerbation of Pathology that is Unique to Humans or Undetectable in Animals 159 8.1.4 The Model May Not Identify Hazards with Low Incidence/Low Severity 159 8.1.5 Potential for Misinterpretation of Reversibility/Recovery for Low]Incidence Findings 160 8.1.6 Potential for Over] or Underestimation of the Relationship to Test Article of Findings that have High Spontaneous Incidence in Laboratory Species, but are Relatively Rare in Humans 160 8.1.7 Exclusive Use of Young, Healthy Animals Kept in Ideal Conditions Gives Limited Predictivity for Aged/Diseased Human Populations 161 8.2 Efficacy/Disease Models as Toxicology Models 162 8.3 Limitations of Efficacy/Disease Models as Toxicology Models 164 8.3.1 Lack of Validation as Safety/Toxicology Models 164 8.3.2 Disease Models Rarely Have All the Elements of the Equivalent Human Disease 165 8.3.3 Limited Sensitivity Produced by Increased Interanimal Variability amongst Diseased Animals and/or Low Animal Numbers 165 8.3.4 Lack of Historical Data 166 8.3.5 Risk Associated with Nonregulated Laboratory Conditions 166 8.4 Limitations of Pathology within In Vivo Toxicology Models 167 8.4.1 Anatomic Pathology Evaluation Will Not Identify Hazards with No Morphological Correlates 167 8.4.2 Limitations of Pathology when Evaluating Moribund Animals or Animals Found Dead on Study 168 8.4.3 Limitations of Anatomic and/or Clinical Pathology End Points within other Types of In Vivo Preclinical Safety Study 168 8.4.4 Limitations of Histopathology Related to Sampling Error 169 8.4.5 Limitations of Quantitative Anatomic Pathology 170 8.4.6 Limitations of Pathology Related to Subjectivity and Pathologist Error 173 8.4.7 Anatomic Pathology Error/Missed Findings 173 8.4.8 Subjectivity and Pathologist Variability 175 8.5 Managing Risk Associated with Subjectivity and the Potential for Pathologist Error 176 8.5.1 Choice of Study Pathologist 176 8.5.2 Peer Review 176 8.5.3 Review of the Anatomic Pathology Data 177 8.5.4 Review of Anatomic Pathology Data Interpretation 177 References 179 Glossary 184 Index 187

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Book SynopsisNon-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of tTrade Review"The book consists of 8 very easy-to-read chapters and highlights (as mentioned in the Preface), �the uncertainties encountered by the pathologist when reading studies� and shows �why pathologists cannot always make up their minds�. The book explains and endorses the fact that explanation of pathology findings in a toxicology study must involve pragmatic (as well as scientific) thinking. Each chapter ends with a good reference section and pages 184 to 186 contain a useful glossary...Overall, there is a lot of useful information packed into this book and it is definitely a suggested read for toxicologists and others involved in seeing pathology data, either as an introduction or a refresher." (Paul Baldrick, Regulatory Toxicology and Pharmacology June 2017)"[T]he standout comment for me is that I was expecting to know what was in the book, but the diversity and richness of the contents was something that both captured my imagination and summarised several of the internal thoughts that I've always held...Each chapter has learning objectives, setting out the upcoming topics. The text is illustrated with some beautiful, predominantly macroscopic photographs and the text is clear, concise and easily followed...This is a really good book...I have really enjoyed reading the text and it is something that I will certainly share with others." (Adam Hargreaves, British Society of Toxicological Pathology May 2017)Table of ContentsList of Contributors xi Preface xiii 1 An Introduction to Pathology Techniques 1Elizabeth McInnes 1.1 Animal Considerations 2 1.2 Necropsy 2 1.3 Lung Inflation with Fixative 5 1.4 Fixation 5 1.5 Making Glass Slides 6 1.5.1 Trimming 6 1.5.2 Tissue Processing 9 1.5.3 Embedding 9 1.5.4 Microtoming 9 1.5.5 Staining 9 1.5.6 Quality Control 11 1.6 Special Histochemical Stains 12 1.7 Decalcification 13 1.8 Immunohistochemistry 13 1.9 Tissue Crossreactivity Studies 15 1.10 Electron Microscopy 15 1.11 In Situ Hybridisation 16 1.12 Laser Capture Microscopy 16 1.13 Confocal Microscopy 16 1.14 Image Analysis 17 1.15 Digital Imaging 17 1.16 Spermatocyte Analysis 17 1.17 Good Laboratory Practice 17 1.18 Inhalation Studies 18 1.19 Continuous]Infusion Studies 18 1.20 Carcinogenicity 19 1.21 Biologicals 19 1.22 The Pathology Report 20 1.23 Conclusion 20 References 20 2 Recording Pathology Data 23Cheryl L. Scudamore 2.1 What is a Pathology Finding? 24 2.2 Standardisation of Pathology Findings 24 2.2.1 Semiquantitative Analysis 24 2.2.2 Nomenclature/Controlled Terminology 26 2.2.3 Ontological Approach 28 2.3 ‘Inconsistencies’ in Pathology Recording 28 2.3.1 Diagnostic Drift 28 2.3.2 Thresholds 28 2.3.3 Lumping versus Splitting 29 2.4 Blind Review 30 2.5 Historical Control Data: Pros and Cons 30 2.6 The Use of Peer Review in Pathology 32 References 32 3 General Pathology and the Terminology of Basic Pathology 35Elizabeth McInnes 3.1 Cellular Responses to Insults 35 3.2 Inflammation 41 3.3 Circulatory Disturbances 46 3.4 Disorders of Tissue Growth 52 3.5 Tissue Repair and Healing 53 3.6 Neoplasia 54 3.7 Immune System 55 References 57 4 Common Spontaneous and Background Lesions in Laboratory Animals 59Elizabeth McInnes 4.1 Rats 62 4.2 Mice 63 4.3 Dogs 66 4.4 Minipigs 66 4.5 Non]Human Primates 67 4.6 Rabbits 67 4.7 Experimental Procedures 67 4.8 Causes of Death in Rats and Mice 67 4.9 Conclusion 68 References 69 5 Target Organ Pathology 72Elizabeth McInnes 5.1 Skin 72 5.2 Eye 76 5.3 Gastrointestinal Tract 78 5.4 Liver 83 5.5 Respiratory System 85 5.6 Urinary System 89 5.7 Lymphoreticular System 94 5.8 Musculoskeletal System 95 5.9 Cardiovascular System 97 5.10 Endocrine System 99 5.11 Reproductive System 102 5.12 Central and Peripheral Nervous System 104 5.13 Ear 106 References 106 6 Clinical Pathology 112Barbara von Beust 6.1 Clinical Pathology in Study Phases and Good Laboratory Practice 112 6.1.1 Preanalytic Phase: Study Plan 113 6.1.2 Analytic Phase: Data Generation 114 6.1.3 Postanalytic Phase: Data Interpretation and Reporting 114 6.1.4 Good Laboratory Practice 114 6.2 What is Measured in Clinical Pathology? 115 6.2.1 Interference by Haemolysis, Lipaemia and Icterus 116 6.3 Haematology 117 6.3.1 Manual and Automated Techniques in Haematology 118 6.3.2 Haematocrit and Red Blood Cell Mass 119 6.3.3 Blood Cells 120 6.3.4 The Standard Haematology Profile 124 6.3.5 Bone Marrow 125 6.4 Coagulation 125 6.4.1 Standard Coagulation Profile 126 6.4.2 Prothrombin Time 127 6.4.3 Activated Partial Thromboplastin Time 127 6.4.4 Fibrinogen 127 6.5 Clinical Chemistry 127 6.5.1 Metabolites 127 6.5.2 Enzymes 129 6.5.3 Electrolytes and Minerals 129 6.5.4 Standard Chemistry Profiles 130 6.6 Urinalysis 131 6.7 Acute]Phase Proteins 131 6.8 The Biomarker Concept 132 6.9 Reference Intervals 133 6.10 Instrumentation, Validation and Quality Control 133 6.11 Data Analysis and Interpretation 134 6.12 Reporting 135 6.13 Food Consumption and Body Weight (Gain) 136 6.14 Organ Weights 136 6.15 Examples of Typical Clinical Pathology Profile Changes in Toxicologic Clinical Pathology 136 6.15.1 Reduced Red Blood Cell Mass due to Chronic Disease 138 6.15.2 Stress Response 139 6.15.3 Reduced Red Blood Cell Mass due to Excessive Blood Sampling 139 6.15.4 Common Artefacts 139 6.16 Microsampling 140 6.17 Conclusion 141 Acknowledgments 141 References 141 7 Adversity: A Pathologist’s Perspective 145Bhanu Singh 7.1 LOAEL, NOEL and NOAEL: Definition 146 7.2 Adversity 147 7.3 Determining Adversity using Pathology Findings: Factors to Consider 149 7.3.1 Severity 149 7.3.2 Functional Effect 1507.3.3 Primary versus Secondary Effects 151 7.3.4 Physiological Adaptability 152 7.3.5 Reversibility of the Lesion 152 7.3.6 Pharmacological Effect 153 7.4 Communicating NOAEL in Toxicity Studies 153 7.5 Conclusion 154 References 154 8 Limitations of Pathology and Animal Models 157Natasha Neef 8.1 Limitations of In Vivo Animal Models 157 8.1.1 Traditional Laboratory Species Used as General Toxicology Models 157 8.1.2 The Test Article May Not have Sufficient Pharmacological Activity in Routine Toxicology Species 158 8.1.3 The Model May Not Identify Hazards Related to Causation or Exacerbation of Pathology that is Unique to Humans or Undetectable in Animals 159 8.1.4 The Model May Not Identify Hazards with Low Incidence/Low Severity 159 8.1.5 Potential for Misinterpretation of Reversibility/Recovery for Low]Incidence Findings 160 8.1.6 Potential for Over] or Underestimation of the Relationship to Test Article of Findings that have High Spontaneous Incidence in Laboratory Species, but are Relatively Rare in Humans 160 8.1.7 Exclusive Use of Young, Healthy Animals Kept in Ideal Conditions Gives Limited Predictivity for Aged/Diseased Human Populations 161 8.2 Efficacy/Disease Models as Toxicology Models 162 8.3 Limitations of Efficacy/Disease Models as Toxicology Models 164 8.3.1 Lack of Validation as Safety/Toxicology Models 164 8.3.2 Disease Models Rarely Have All the Elements of the Equivalent Human Disease 165 8.3.3 Limited Sensitivity Produced by Increased Interanimal Variability amongst Diseased Animals and/or Low Animal Numbers 165 8.3.4 Lack of Historical Data 166 8.3.5 Risk Associated with Nonregulated Laboratory Conditions 166 8.4 Limitations of Pathology within In Vivo Toxicology Models 167 8.4.1 Anatomic Pathology Evaluation Will Not Identify Hazards with No Morphological Correlates 167 8.4.2 Limitations of Pathology when Evaluating Moribund Animals or Animals Found Dead on Study 168 8.4.3 Limitations of Anatomic and/or Clinical Pathology End Points within other Types of In Vivo Preclinical Safety Study 168 8.4.4 Limitations of Histopathology Related to Sampling Error 169 8.4.5 Limitations of Quantitative Anatomic Pathology 170 8.4.6 Limitations of Pathology Related to Subjectivity and Pathologist Error 173 8.4.7 Anatomic Pathology Error/Missed Findings 173 8.4.8 Subjectivity and Pathologist Variability 175 8.5 Managing Risk Associated with Subjectivity and the Potential for Pathologist Error 176 8.5.1 Choice of Study Pathologist 176 8.5.2 Peer Review 176 8.5.3 Review of the Anatomic Pathology Data 177 8.5.4 Review of Anatomic Pathology Data Interpretation 177 References 179 Glossary 184 Index 187

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Book SynopsisTable of ContentsContents About the Companion Website ix Section I Review of Math Fundamentals 1 1 Math Fundamentals: Self-assessment 3 Self-assessment Exercises 3 2 Review of Key Medical Math Fundamentals: Decimals 11 2.1 Relative Values of Decimal Numbers 11 2.2 Properly Communicating Decimal Numbers 12 2.3 The Rules for the Use of Zero in Decimal Numbers 13 2.4 Comparing Decimals – Which Number Is Larger? 14 2.5 A Quick Guide to Using Scientific Notation 15 2.6 Tips for Adding and Subtracting Decimal Numbers 17 2.7 Tips for Multiplying Decimal Numbers 18 2.8 Tips for Dividing Decimal Numbers 19 2.9 Accurately Rounding Decimal Numbers 22 2.10 Chapter 2 Practice Problems 23 3 Review of Key Math Fundamentals: Fractions 27 3.1 Fundamentals of Working with Medical Math Fractions 27 3.2 Working with Improper Fractions, Proper Fractions, and Mixed Numbers 28 3.3 Equivalent Fractions in Medical Math 29 3.4 Simplifying or Reducing Fractions 30 3.5 Adding Fractions in Medical Math 31 3.6 Subtracting Fractions in Medical Math 33 3.7 Multiplying Fractions in Medical Math 34 3.8 Dividing Fractions in Medical Math 37 3.9 Conversion between Fractions and Decimals 39 3.10 Rounding Fractions in Medical Math 41 3.11 Chapter 3 Practice Problems 42 4 Review of Key Math Fundamentals: Percentages 47 4.1 Conversion of Percentages to Fractions 47 4.2 Conversion between Percentages and Decimal Numbers 48 4.3 Conversion of Fractions to Percentages 49 4.4 Finding Percentages of a Whole 49 4.5 Subtracting or Adding the Percentage Fraction of the Whole 50 4.6 Determining Percentages Represented by the Fractional Component 52 4.7 Chapter 4 Practice Problems 53 5 Review of Key Math Fundamentals: Finding the Unknown X 57 5.1 Analyzing the Problem and Setting up the Equation 57 5.2 Addition: Moving Numbers to the Other Side of the Equation 58 5.3 Subtraction: Moving Negative Numbers or a Negative UnknownX 59 5.4 Finding the Unknown X in Multiplication Problems 62 5.5 When the Unknown X is in the Denominator 67 5.6 Finding the Unknown X in Division Problems 70 5.7 Unknown X Involving Division of Fractions 71 5.8 Chapter 5 Practice Problems 74 Section II Understanding Units and Labels 77 6 Measurements Used in Veterinary Medicine 79 6.1 Metric Units: The Basics 79 6.2 Metric Units of Weight and Mass 80 6.3 Metric Units of Volume 82 6.4 Metric Units of Length 83 6.5 Metric Units of Concentration and Density 84 6.6 Nonmetric Units: Household, Apothecary, and Avoirdupois Units 85 6.7 Conversion between Quantities of Volume and Mass: Special Cases 87 6.8 Converting Between Units: The Proportion and Cancel-Out Methods 87 6.8.1 Using the Proportion Method 88 6.8.2 Using the Cancel-out Method 91 6.9 Estimating the Answer: Does Your Answer Make Sense? 93 6.10 Chapter 6 Practice Problems 96 7 Understanding Drug Orders and Drug Labels 99 7.1 The Dosage Regimen 99 7.1.1 The Dosage Regimen: Doses and Dosages 100 7.1.2 The Dosage Regimen: The Route of Administration 100 7.1.3 The Dosage Regimen: The Dose Interval 102 7.2 The Dosage Form 102 7.3 The Best Practices for Writing Drug Orders 103 7.3.1 Handling Unclear Drug Orders 104 7.4 Understanding the Drug Label: The Drug Names 104 7.5 Understanding the Drug Label: Concentrations and Dosage Forms 107 7.6 Understanding the Drug Label: Regulatory Label Information 109 7.6.1 Controlled Substances and Prescription Labeling 110 7.6.2 Prescription, Legend, and Over-The-Counter Label Indicators 110 7.7 Understanding the Drug Label: Hazards, Storage, and Expiration Dates 110 7.7.1 Storage Information on the Label 111 7.7.2 Expiration Dates 111 7.8 Chapter 7 Practice Problems 112 Section III Dose Calculations 115 8 Basic Dose Calculations 117 8.1 The Basic Steps in Dose Calculation 117 8.2 Converting the Animal’s Weight into the Units Needed to Calculate the Dose 119 8.3 Determining the Dose for the Patient 120 8.4 Determining the Amount of Dose Forms Needed per Dose 122 8.5 Determining the Number of Dosage Forms Needed to Complete the Dosage Regimen 125 8.5.1 The Most Common Mistake Made when Determining the Total Number of Units to Be Dispensed 126 8.6 Determining the Cost for Dispensed Medication 128 8.7 Using a Syringe with Liquid Dosage Formulations 129 8.7.1 Syringes in Veterinary Medicine 130 8.7.2 Measuring Fluid within the Syringe 131 8.8 Chapter 8 Practice Problems 132 9 Intravenous Infusion Calculations 137 9.1 Performing IV Infusions and the Use of IV Administration Sets 137 9.2 The Basics of Setting IV Fluid Rate Using the Drip Chamber 138 9.3 Setting the IV Fluid Rate: Constant Rate Infusions (CRI) 142 9.4 Calculating Infusion Rates when Adding Drugs to IV Fluids 144 9.5 Calculating Standard IV Fluid Rates 147 9.6 Calculating IV Fluid Rate Stop Times 151 9.7 Chapter 9 Practice Problems 153 Section IV Other Calculations Used in Veterinary Medicine 157 10 Ratios, Proportions, and Dilutions 159 10.1 Ratios and Proportions 159 10.2 The Basics of Making a Dilution 161 10.3 Making Serial Dilutions 162 10.4 Calculating Diluent Needed to Deliver a Specific Dose or Drug Concentration 163 10.5 Calculating Dilutions Using the V1 × C1 = V2 × C2 Formula 164 10.6 Diluting Percent Solutions 166 10.7 Diluting Solutions Expressed as Ratios 167 10.8 Making Dilutions with Mixed Types of Concentrations 168 10.9 Chapter 10 Practice Problems 169 11 Additional Calculations Used by Veterinary Professionals 171 11.1 Mean, Median, Mode, and Range 171 11.2 Converting between Fahrenheit and Celsius 175 11.3 Roman Numerals 179 11.4 Chapter 11 Practice Problems 181 Appendix: Answers to Practice Problems 183 Index 223

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Book SynopsisFully integrative approach to the socibiology of caviomorph rodents Brings together research on social systems with that on epigenetic, neurendocrine and developmental mechanisms of social behavior Describes the social systems of many previously understudied caviomorph species, identifying the fitness costs and benefits of social living in current day populations as well as quantified evolutionary patterns or trends Highlights potential parallels and differenceswith other animal models Table of ContentsAcknowledgments ix Notes on contributors xi Introduction xv 1 The caviomorph rodents: distribution and ecological diversification 1 Ricardo A. Ojeda, Agustina A. Ojeda and Agustina Novillo 2 Diversity of social behavior in caviomorph rodents 28 Christine R. Maher and Joseph R. Burger 3 Comparative neurobiology and genetics of mammalian social behavior 59 Annaliese Beery, Yasmin Kamal, Raúl Sobrero and Loren D. Hayes 4 Developmental underpinnings of social behavior 91 Valentina Colonnello, Ruth C. Newberry and Jaak Panksepp 5 Dispersal in caviomorph rodents 119 Eileen A. Lacey 6 Mechanisms of social communication in caviomorph rodents 147 Gabriel Francescoli, Selene Nogueira and Cristian Schleich 7 Causes and evolution of group-living 173 Luis A. Ebensperger and Loren D. Hayes 8 Rodent sociality: a comparison between caviomorphs and other rodent model systems 201 Nancy G. Solomon and Brian Keane 9 Cooperation in caviomorphs 228 Rodrigo A. Vásquez 10 Caviomorphs as models for the evolution of mating systems in mammals 253 Emilio A. Herrera 11 Parent-offspring and sibling-sibling interactions in caviomorph rodents: a search for elusive patterns 273 Zuleyma Tang-Martínez and Elizabeth R. Congdon 12 Fitness consequences of social systems 306 Loren D. Hayes and Luis A. Ebensperger 13 An integrative view of caviomorph social behavior 326 Luis A. Ebensperger and Loren D. Hayes Glossary 356 Index 371

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Book SynopsisThe Ichneumonoidea is a vast and important superfamily of parasitic wasps, with some 60,000 described species and estimated numbers far higher, especially for small-bodied tropical taxa. The superfamily comprises two cosmopolitan families - Braconidae and Ichneumonidae - that have largely attracted separate groups of researchers, and this, to a considerable extent, has meant that understanding of their adaptive features has often been considered in isolation. This book considers both families, highlighting similarities and differences in their adaptations. The classification of the whole of the Ichneumonoidea, along with most other insect orders, has been plagued by typology whereby undue importance has been attributed to particular characters in defining groups. Typology is a common disease of traditional taxonomy such that, until recently, quite a lot of taxa have been associated with the wrong higher clades. The sheer size of the group, and until the last 30 orTrade Review"Overall, this is a highly valuable compendium of known information, as well as currently unanswered questions, concerning ichneumonoid wasps.... Quicke is to be congratulated for producing a standard work that I, for one, will be consulting for a long time." (American Entomologist, 2016) "This is certainly a field with many pitfalls, but there is hardly a better guide through it than Professor Quicke." (International Journal of Environmental Studies, 9 March December 2015) "It sounds like a backhanded compliment to say that this is the best book of its kind, when I have already said that it is the only book of its kind. However, The Braconid and Ichneumonid Parasitoid Wasps goes beyond being the best of a limited field – it is a truly impressive assemblage of information on an intriguing and important group of insects. I hope that it inspires more people to work in the field." (Bulletin de la Société d'entomologie du Canada, 2015)Table of ContentsPreface xiii Acknowledgements xv 1 Introduction 1 Life history 5 Systematics 6 Part 1 Morphology and Biology 7 2 Adult External Morphology 9 Head 10 Antennal sensilla 12 Antennal glands and tyloids 14 Palps 15 Mesosoma 15 Legs 17 Wings wing venation and wing cells 18 Confusing and sometimes erroneously applied vein names 26 Wing flexion lines 27 Metasoma 29 Sexual dimorphism 30 Male external genitalia 32 3 The Ovipositor and Ovipositor Sheaths 35 The act of oviposition 39 Functional morphology of wood-drillers 41 Ovipositor stabilisation guides and buckling force 43 Ovipositor notches and endoparasitism 44 Ovipositor steering mechanisms 44 Proposed evolutionary and related ovipositor transitions 48 Number position and possible functions of ovipositor valvilli 50 Venom retention and delivery 52 Ovipositor secretory pores 53 Ovipositor sensilla 54 Ovipositor sheaths 55 4 Internal and Reproductive Anatomy 57 Nervous system 58 Digestive tract 58 Female internal reproductive system 59 Ovaries 59 Time scale of egg maturation 60 Spermatheca 61 Common oviduct and vaginal gland 62 Venom gland and reservoir 63 Dufour’s gland 64 Cuticular hydrocarbons 66 Sex pheromones 67 Male internal reproductive system 68 Sperm ultrastructure 69 Spermatogeny index 70 5 Immature Stages 71 Eggs and oögenesis 72 Hydropic and anhydropic eggs 72 Embryogenesis 73 Embryonic membranes 75 Larva 76 Larval feeding and nutrition 81 Larval food consumption and dietary efficiency 82 Lipid metabolism 82 Respiration in endoparasitoids 83 Larval secretions 83 The pupal stage 84 Cocoons 84 6 Idiobionts Koinobionts and Other Life History Traits 87 Parasitoidism 88 Idiobiont and koinobiont strategies 88 Generalists and specialists 89 Ecto- and endoparasitism 90 Permanent host paralysis 91 Gregarious development 91 Superparasitism 92 Larval combat and physiological suppression 93 Adaptive superparasitism 95 Multiparasitism 96 Obligate and preferential multiparasitism 99 Hyperparasitism and pseudohyperparasitism 99 Kleptoparasitism 100 Evolution of life history strategies 100 7 Sex Courtship and Mating 107 Sex determination 108 Local mate competition and avoidance of inbreeding 110 Sex allocation 110 Protandry and virginity 112 Thelytoky and cytoplasmic incompatibility 113 Mate location 117 Courtship 119 Swarming and lekking 120 Mating position 121 Multiple mating and sperm competition 121 Sex-related scent glands 123 Genome size and recombination 125 Cytogenetics 125 8 Host Location Associative Learning and Host Assessment 127 Tritrophic interactions 129 Host acceptance 130 Associative learning 130 Biosensors 134 Patch use 134 9 Overcoming Host Immune Reaction and Physiological Interactions With Host 137 Overcoming host immunity in endoparasitoids 138 Passive evasion of encapsulation by parasitoid eggs 139 Avoiding encapsulation by physical means 139 Effect of host age and haemocyte number 141 Other host defence mechanisms 141 Venoms 141 Neurophysiological venom actions 143 Venom effects on host immune response 144 Polydnaviruses 145 Effects of polydnaviruses on hosts 152 Other reproductive viruses 155 Improving host quality 156 Host castration and similar effects 156 Teratocytes 158 Intraspecific variation in resistance to parasitoids 159 Effects on host moulting pattern 160 Parasitoid-induced changes in host behaviour 160 10 Convergent Adaptations 163 Antennal hammers and vibrational sounding 164 Enlarged mandibles 167 Chisel-like mandibles 168 Concealed nectar extraction apparatus 168 Reduced number of palpal segments 169 ‘Facial’ protruberances 169 Frontal depressions 170 Dorsal ridges on head or mesosoma 170 Brachyptery and aptery 170 Dorso-ventral flattening 171 Postpectal carina 173 Propodeal spines 173 ‘Fossorial’ legs 173 Fore tibial spines 174 Fore tibial apical tooth 174 Expanded hind basitarsi 174 Toothed hind femur 174 Distitarsal scraper 175 Pectinate claws and claws with angular basal lobes 175 Glabrous wing patches and wing membrane scleromes 176 Carapacisation 177 Petiolate metasomas 177 Modifications to the posterior metasomal margin 178 Spermathecal colour 179 Compression of apical part of metasoma 179 The ‘ophionoid facies’ 179 White antennal stripes and tips 180 White ovipositor sheath stripes and tips 181 Number of larval instars 182 Egg-larval parasitism 182 Disc-like larval antennae 182 Reduction of larval hypostomal spur 183 Wide and heavily sclerotised larval epistoma 184 Suspended cocoons 184 Polyembryony 184 Phytophagy and cecidogenesis 184 Part 2 Taxonomic and Systematic Treatment 187 11 Overview of Ichneumonoidea: Relationships and Systematics 189 Monophyly of Ichneumonoidea Ichneumonidae and Braconidae 190 Relationship of Ichneumonoidea to other Hymenoptera 190 Fossil history and family-level phylogeny 192 Brief history of classification 194 Ancestral biology of Ichneumonoidea 196 Separating ichneumonids from braconids 197 Identifying specimens 198 12 Phylogeny and Systematics of The Braconidae 201 Historical perspective 202 Morphophylogenetic hypotheses 202 Molecular phylogenetics 204 Braconid classification 205 Eoichneumoninae† 205 Trachypetiformes 205 Trachypetinae 205 Cyclostomes incertae sedis 209 Protorhyssalinae et al. 209 Apozyginae 210 The aphidioid clade or ‘Gondwanan’ complex 212 Aphidiinae 212 Maxfischeriinae 224 Mesostoinae (including Canberreriini and Hydrangeocolini) 225 The remaining cyclostomes 229 Doryctinae (including Ypsistocerini) 231 Pambolinae 236 Rhysipolinae 237 Rhyssalinae 238 Rogadinae s.l. Hormiinae Lysiterminae 243 Betylobraconinae 243 Hormiinae 243 Lysiterminae 245 Rogadinae sensu stricto 246 Alysioid subcomplex including Braconinae 250 Alysiinae and Opiinae 250 Alysiinae 251 General Alysiinae biology 251 Alysiini 253 Dacnusini 255 Opiinae 256 Braconinae 260 Exothecinae 269 Gnamptodontinae (= Gnaptodontinae) 270 Telengaiinae 271 The non-cyclostomes 271 Sigalphoid complex 271 Agathidinae 272 Sigalphinae 275 Helconoid complex 278 Helconinae 279 Helconoid group incertae sedis 281 Blacinae 282 Acampsohelconinae 283 Macrocentrine subcomplex 284 Macrocentrinae 284 Charmontiinae 287 Amicrocentrinae 287 Xiphozelinae 288 Homolobinae 290 Microtypinae 292 Orgilinae 292 Euphoroid complex 294 Euphorinae 294 Cenocoeliinae 310 The microgastroids 311 Cardiochilinae 312 Cheloninae (including Adeliini) 315 Dirrhopinae 319 Ichneutinae 320 Khoikhoiinae 322 Mendesellinae 322 Microgastrinae 322 Miracinae 335 Unplaced subfamilies 335 Masoninae 335 Meteorideinae 337 13 Phylogeny and Systematics of The Ichneumonidae 341 History of ichneumonid classification 342 Henry Townes (1913–90) and his idiosyncratic nomenclature 344 The extinct subfamilies 344 Tanychorinae† 344 Palaeoichneumoninae† 346 Labenopimplinae† 348 Pherombinae† 349 Townesitinae† 349 The xoridiformes 349 Xoridinae 349 The labeniformes 353 Labeninae 353 Groteini 355 Labenini 355 Poecilocryptini 356 The pimpliformes 356 Acaenitinae 356 Collyriinae 359 Cylloceriinae 360 Diacritinae 360 Diplazontinae 361 Orthocentrinae (= Helictinae) 366 Pimplinae 367 Delomeristini 369 Ephialtini (= Pimplini of Townes) 369 Polysphincta group 371 Pimplini 373 Poemeniinae (= Neoxoridinae) 378 Poemeniini 378 Pseudorhyssini 378 Rodrigamini 378 Rhyssinae 379 The ichneumoniformes 383 Adelognathinae 383 Agriotypinae 385 Alomyinae 387 Cryptinae 388 Aptesini 391 Cryptini 391 Phygadeuontini 393 Ichneumoninae 394 The brachycyrtiformes 398 Brachycyrtinae 398 Claseinae (Clasinae) 398 Pedunculinae 399 The orthopelmatiformes 400 Orthopelmatinae 400 The ophioniformes 400 Lower ophioniformes 402 Banchinae 402 Lycorininae 406 Sisyrostolinae 407 Stilbopinae 407 Tryphoninae 411 Middle ophioniformes 416 Ctenopelmatinae 416 Mesochorinae 421 Metopiinae 422 Oxytorinae 424 Tatogastrinae 425 Tersilochinae (including Neorhacodinae and Phrudinae s.s.) 426 Higher ophioniformes 430 Anomaloninae 430 Campopleginae 432 Cremastinae 438 Hybrizontinae 439 Nesomesochorinae 442 Ophioninae 442 Unplaced subfamilies 445 Eucerotinae 445 Microleptinae 447 Part 3 Ecology and Diversity 451 14 Ecology 453 Adult diet 454 Host-feeding 454 Water sugar and pollen feeding 457 Fecundity 460 Voltinism and seasonality 462 Daily activity patterns 462 Diapause 463 Cold hardiness hibernation and overwintering 465 Coloration and thermoregulation 467 Biological control 467 Effect on host food consumption 471 Artificial diets 474 Artificial hosts 475 Use of alternative hosts 475 Hyperparasitism and kleptoparasitism 476 Predation 477 Pathogens 477 Transmission of host pathogens 479 Dispersal 480 Coloration and mimetic rings 480 Palatability and odours 481 Competition 482 Apparent competition 482 Host ranges of parasitoids 483 Parasitoid guilds and food webs 484 Evolution of host ranges and speciation 486 15 Local and Global Patterns In Diversity 489 Field research in the tropics and anomalous diversity 490 Estimation of global ichneumonoid species richness 492 Distribution related to climate and latitude 496 The nasty host hypothesis 497 Biogeography 503 Islands and their parasitoid faunas 505 Species accumulation curves 506 Altitudinal gradients 507 Estimating local species diversity 508 Ichneumonoidea as biodiversity indicators 510 Conservation 510 Effect of habitat degradation on ichneumonoid composition 511 Significance of cryptic species 511 16 Collecting and Rearing Ichneumonoidea 513 Field collecting adults 516 Pan traps 518 Sweep netting 519 Light trapping 521 Canopy fogging 521 Malaise traps 521 Rearings from wild-collected hosts 523 Rearing leaf rollers and tiers 524 Substrate rearings 524 Culturing 524 Mating in captivity 525 Mass rearing 525 Mounting specimens for taxonomic study 526 Preparing specimens from alcohol storage 526 Direct pinning 527 Side gluing 527 Card rectangles and card points 527 Secondary staging 528 Labelling 528 Preserving specimens for DNA analysis 528 Packaging and posting specimens to other workers 530 17 Epilogue 533 Phylogenetic questions 534 Host and parasitism questions 534 Physiological questions 535 Ecological questions 536 Glossary 539 References 547 Author index 633 General index 653 Host index 659 Ichneumonoid genus tribe and subfamily index 665 Ichneumonoidea species index 677 Color Plate Sections Are Inserted Between Pages Noted Below First 13-page colour plate section (between pages 112 and 113) Second 13-page colour plate section (between pages 224 and 225) Third 13-page colour plate section (between pages 336 and 337) Fourth 13-page colour plate section (between pages 448 and 449)

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Book SynopsisA unique, case-based guide to diagnosing and treating a wide range of conditions encountered in canine internal medicine Canine Internal Medicine: What''s Your Diagnosis? is an ideal guide to how internal medicine cases are handled in the clinical setting. This text is part of an exciting series, which combines problem-based learning, case studies, and questions and answers. Designed for veterinarians in practice and students, the series presents material in a format designed to enhance critical thinking and understanding. Adopting a case-based approach, chapters are built around body systems and are directed by questions to test the reader''s ability to interpret clinical history, illustrative images and diagnostic results in order to provide differential diagnoses, diagnostic plans and treatment options. Common pitfalls in diagnosis and management are discussed, and you will benefit from the experience of the author as a busy and experienceTable of ContentsAcknowledgements vii Dedication ix How to Use This Book xi Introduction xiii Section A Endocrinology 1 Case 1 presenting with polyuria/polydipsia 3 Case 2 presenting with seizures 17 Case 3 presenting with lethargy and weight loss 27 Case 4 presenting with alopecia and polyuria/polydipsia 39 Case 5 presenting with weight gain, lethargy and coat abnormalities 53 Section B Haematology and Immunology 61 Case 6 presenting with lethargy and pigmenturia 63 Case 7 presenting with lethargy and vomiting 75 Case 8 presenting with lethargy and lameness 85 Case 9 presenting with lethargy and lameness also 99 Section C Hepatobiliary Disease 105 Case 10 presenting with abdominal pain 107 Case 11 presenting with mentation abnormalities 117 Case 12 presenting with jaundice 131 Section D Gastroenterology 153 Case 13 presenting with diarrhoea, ascites and seizures 155 Case 14 presenting with inappetence and vomiting 167 Case 15 presenting with diarrhoea and weight loss 181 Case 16 presenting with regurgitation 195 Section E Respiratory 205 Case 17 presenting with cough and tachypnoea 207 Case 18 presenting with episodes of dyspnoea 217 Case 19 presenting with tachypnoea 225 Section F Ear, Nose and Throat 237 Case 20 presenting with exercise intolerance 239 Case 21 presenting with epistaxis 247 Section G Cardiovascular 259 Case 22 presenting with lethargy and ascites 261 Case 23 presenting with lethargy and heart murmur 275 Section H Urology and Nephrology 287 Case 24 presenting with azotaemia on pre-anaesthetic blood sample 289 Case 25 presenting with dysuria 303 Case 26 presenting with haematuria 311 Section I Reproductive/Genital Tract 325 Case 27 presenting with blood from the penis 327 Section J Oncology 339 Case 28 presenting with pelvic limb swelling 341 Case 29 presenting with weight loss and tachypnoea 349 Case 30 presenting with lymphadenomegaly 361 Section K Neurology 379 Case 31 presenting with ocular changes and regurgitation 381 Case 32 presenting with stiffness and dysphagia 389 Section L Infectious diseases 395 Case 33 presenting with lethargy and polyuria 397 Case 34 presenting with lethargy, vomiting and jaundice 413 Appendix 1: Index of Tables and Figures, Pearls and Clinical Skills Generated 421 Appendix 2: Diagnosis by Case 435 Appendix 3: Conversion Table of SI to Common Units 437 Index 439

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Book SynopsisATLAS OF Small Animal Diagnostic Imaging Comprehensive and up-to-date resource on the interpretation of diagnostic images in small animals using survey radiographs and other modalities Atlas of Small Animal Diagnostic Imaging provides a comprehensive, multimodality atlas of small animal diagnostic imaging, with high-quality images depicting radiography, scintigraphy, ultrasonography, computed tomography, and magnetic resonance imaging. Taking a traditional body systems approach, the book offers an image-intensive resource to survey radiographs with some other imaging modalities being used to emphasize interpretation of survey radiographs. The Atlas offers clinically relevant information for small animal practitioners and students. Each body structure is thoroughly covered and well-illustrated, with discussion of the strengths and weaknesses of each modality in various scenarios. Edited by three experienced radiographers, The Atlas of Small Animal Diagnostic Imaging contains informatiTable of ContentsContributors ix Acknowledgments x Preface xi About the Companion Website xii Section I Introduction and Physics 1 The Science, Art, and Philosophy of Radiographic Interpretation 3 Matthew D. Winter 2 Physics of Diagnostic Imaging 10 Elizabeth Huyhn, Elodie E. Huguet, and Clifford R. Berry 3 Computed Tomography and Magnetic Resonance Imaging 16 Elodie E. Huguet, Elizabeth Huyhn, and Clifford R. Berry 4 Ultrasonography 27 Elizabeth Huyhn, Elodie E. Huguet, and Clifford R. Berry 5 Nuclear Scintigraphy 36 Elizabeth Huyhn, Elodie E. Huguet, and Clifford R. Berry Section II Musculoskeletal 6 Anatomy, Variants, and Interpretation Paradigm 43 Nathan C. Nelson 7 Developmental Orthopedic Disease 79 Elizabeth Huynh 8 Imaging of Joint and Tendon Diseases 104 Nathan C. Nelson 9 Fractures and Fracture Healing 131 Nathan C. Nelson 10 Aggressive Bone Disease 149 Erin Porter and Nathan C. Nelson 11 Imaging of the Head 166 Nathan C. Nelson 12 Imaging of the Spine 213 Nathan C. Nelson Section III Thorax 13 Anatomy, Variants, and Interpretation Paradigm 255 Clifford R. Berry and Elizabeth Huyhn 14 Extrathoracic Structures 307 Clifford R. Berry and Federico R. Vilaplana Grosso 15 Pleural Space 329 Clifford R. Berry and Elodie E. Huguet 16 Pulmonary Parenchyma 346 Clifford R. Berry and Elodie E. Huguet 17 Mediastinum 392 Silke Hecht 18 Cardiovascular System 444 Elodie E. Huguet, Sandra Tou, and Clifford R. Berry 19 Feline Thorax 497 Martha M. Larson and Clifford R. Berry Section IV Abdomen 20 Anatomy, Variants, and Interpretation Paradigm 545 Elodie E. Huguet, Clifford R. Berry, and Robson Giglio 21 Extraabdominal Structures and the Abdominal Body Wall 598 Matthew D. Winter 22 The Peritoneal and Retroperitoneal Space 605 Matthew D. Winter 23 Hepatobiliary Imaging 616 Matthew D. Winter 24 Spleen 634 Cintia R. Oliveira 25 Gastrointestinal Tract 667 Seamus Hoey 26 Pancreas 687 Cintia R. Oliveira and Nathan C. Nelson 27 Urogenital Tract 720 Elizabeth Huynh 28 Adrenal Glands and Lymph Nodes 758 Elizabeth Huynh Appendix I Musculoskeletal Review Paradigm 790 Appendix II Thoracic Radiology Checklist 791 Appendix III Abdominal Radiology Checklist 795 Index 798

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Book SynopsisTable of ContentsList of Contributors ix 1 The Normal Anatomy of the Neck 1David Bainbridge 2 The Normal Anatomy of the Osseous and Soft Tissue Structures of the Back and Pelvis 9Leo B. Jeffcott, Jessica A. Kidd and David Bainbridge 2.1 Normal Anatomy of the Osseous Structures 9 2.2 Normal Anatomy of the Soft Tissue Structures of the Back 21 2.3 Normal Anatomy of the Soft Tissue Structures of the Pelvis 30 3 The Normal Anatomy of the Nervous System 39Constanze Fintl 4 Kinematics 49Rene van Weeren 5 Neurological Examination of the Back and Pelvis 73Constanze Fintl 6 Clinical Examination 81Graham A. Munroe 7 Radiography of the Cervical Spine 95Marianna Biggi, Gabriel Manso-Díaz and Renate Weller 8 Radiography of the Back 107Frances M.D. Henson 9 Nuclear Scintigraphy and Computed Tomography of the Neck, Back and Pelvis 121Sarah Powell 10 Ultrasonography 143Mary Beth Whitcomb, Luis P. Lamas and Marcus Head 10.1 Ultrasonography of the Thoracic Spine 143 10.2 Ultrasonography of the Pelvis, Lumbar Spine and SacroIliac Region 149 11 Thermography 165Tracy Turner 12 Neck Pathology 175Richard Hepburn 13 Back Pathology 195Adam Driver, Frances M.D. Henson, Jessica A. Kidd, Luis P. Lamas and Rob Pilsworth 13.1 Traumatic damage 195 13.2 Over Riding Dorsal Spinous Processes (‘Kissing Spines’) 208 13.3 Miscellaneous Osseous Pathology 216 13.4 Pathology of the Supraspinous and Dorsal Sacroiliac Ligaments 224 14 Sacroiliac Dysfunction 239Leo B. Jeffcott 15 Muscular Disorders 249Richard J. Piercy and Renate Weller 16 Integrative and Physical Therapies 265Joyce Harman and Mimi Porter 16.1 Integrative Therapies 265 16.2 Physical Therapies 278 17 Rehabilitation 283Mary Bromiley Index 297

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Book SynopsisProvides an interdisciplinary approach to the veterinary dental patient and offers guidance on all aspects of integrating dentistry into veterinary general practice The Veterinary Dental Patient: A Multidisciplinary Approach helps veterinarians understand the dental aspects of every canine and feline patient and shows them how to effectively manage their oral health. It also provides guidance to the rest of the veterinary team so they can offer a coordinated approach when recommending and performing veterinary dentistry as a regular part of general practice. Edited by two prominent veterinary dentists who are Board Certified in both Europe and the United States, the text includes the latest information on safe anesthetic and monitoring protocols, accurate diagnosis and management, and referring patients to specialists. Chapters cover: establishing a dental presence in general veterinary practice; nutrition, oral health, and feeding dental patients; local, regional, and systemic complications of dental diseases; pain management; ophthalmic considerations; common situations for malpractice and mistakes; oral and maxillofacial surgery; extraction techniques and equipment; drug dosages and more. The book also offers several helpful appendixes. The Veterinary Dental Patient: A Multidisciplinary Approach is an essential book for all vets in general small animal practice as well as the wider veterinary team, including managers, veterinary nurses and technicians, and administrative staff.Table of ContentsList of Contributors vii Preface ix Acknowledgments xi About the Companion Website xiii Part I General Considerations: How to Start Dentistry 1 1 Establishing a Dental Presence within a General Veterinary Practice 3Jerzy Gawor 2 Marketing and Communication in Veterinary Dentistry 27Rachel Perry 3 Teaching Veterinary Dentistry 37Zlatko Pavlica, Jerzy Gawor, and Lisa Mestrinho 4 Distribution of Tasks Around the Dental Patient in General Practice: Receptionists, Technicians, and Other Veterinary Team Members 45Mary Berg 5 Prophylactic Program for Oral Health 59Brook Niemiec 6 Nutrition, Oral Health, and Feeding Dental Patients 75Michał Jank 7 Antimicrobials in Veterinary Dentistry 87J. Scott Weese 8 Dental Patient Welfare 109Kymberley C. McLeod Part II The Dental Patient 119 9 Local, Regional, and Systemic Complications of Dental Diseases 121Jerzy Gawor and Brook Niemiec 10 Hereditary Oral Disorders in Purebred Dogs and Cats 133Jerzy Gawor 11 Pain Management in the Dental Patient 139Paulo Steagall and Peter Pascoe 12 Anesthesia of the Dental Patient 169Victoria M. Lukasik 13 The Dental Patient and Its General Conditions: Cardiac Disease, Diabetes Mellitus, Pregnancy, History of Seizures, and Brachycephalic Syndrome 189Eva Eberspächer-Schweda 14 Ophthalmic Considerations in the Veterinary Dental Patient 201Jamie J. Schorling 15 Oral Health in the Context of Other Planned Surgeries 211Daniel Koch 16 Systemic Diseases Influencing Oral Health and Conditions 219Jerzy Gawor 17 Common Situations of Malpractice and Mistakes, and How Best to Avoid Them 233Jerzy Gawor and Brook Niemiec 18 Dentistry Through Life: Pediatric and Geriatric Dentistry 245Jerzy Gawor and Brook Niemiec Part III Dentistry in Daily Practice: What Every Veterinarian Should Know 259 19 Management of the Dental Patient 261Jerzy Gawor and Brook Niemiec 20 Professional Dental Cleaning 269Brook Niemiec 21 Oral and Maxillofacial Surgery: What’s the Difference? 291Jerzy Gawor 22 Extraction Techniques and Equipment 305Brook Niemiec 23 Oral Emergencies 319Jerzy Gawor 24 Feline Dentistry 339Jerzy Gawor and Brook Niemiec Part IV When to Call the Specialist 363 25 A Brief Introduction to Specific Oral and Dental Problems that Require Specialist Care 365Jerzy Gawor 26 How to Cooperate with a Specialist 373Brook Niemiec Useful Algorithms for the Management of Oral Problems 377Jerzy Gawor Appendix A: Drugs and Doses 387Margo Karriker Appendix B: Instruments Handling and Sharpening 393Jerzy Gawor Appendix C: Abbreviations and Dental Charts 399Jerzy Gawor Appendix D: List of Hereditary Problems and Breed Predispositions in Dogs and Cats 409Jerzy Gawor Appendix E: Tolerance of Malocclusion and Dental Abnormalities in Dogs 419Jerzy Gawor Appendix F: Assisted Feeding in Dental Patients (website) 423Michał Jank and Jerzy Gawor Index 429

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Book SynopsisPharmacology in Veterinary Anesthesia and Analgesia A concise yet comprehensive and usable pharmacological resource for veterinary practitioners In Pharmacology in Veterinary Anesthesia and Analgesia, a team of distinguished veterinary practitioners delivers a singular and comprehensive text dedicated to anesthetic drug pharmacology and drug interactions related specifically to anesthetic drugs in a veterinary setting. This concise, easily navigable reference combines information scattered throughout the academic literature and covers mechanisms of action of commonly used drugs in commonly encountered species, drug interactions, and clinical uses of anesthetic drugs. The volume explores drug metabolism, the effects of various drugs on organ systems, risks of adverse effects, as well as the impact of anesthesia on drugs, and the effects of drugs on anesthesia. Readers will also find: A thorough introduction to pharmacokinetics, pharmacodynamics, and pharmacogenomics in veterinary anes

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Book SynopsisA concise and practical quick reference guide to treating reptiles in first opinion veterinary practice Reptile Medicine and Surgery in Clinical Practice is the ideal guide for the busy veterinarian treating reptile cases. Designed as a quick reference guide, but with comprehensive coverage of all the topics needed for first opinion practice, the book presents the principles of reptile medicine and surgery. Richly illustrated chapters cover anatomy, physiology, behaviour, husbandry, reproduction, common diseases and disorders, and much more. Application in a clinical setting is emphasized throughout, including guidance on the physical examination, diagnostic testing and imaging, treatment options, and anaesthetic and surgical techniques. Practical quick-reference guideideal for the busy, first-opinion veterinary practitionerRichly illustrated in full colour throughoutEdited by a team of highly experienced exotic animal veterinariansUseful reference for those studying for postgradTrade Review“There are 33 chapters covering everything from anatomy and husbandry, to diseases, imaging, nutrition and surgery. Diseases have been covered in chapters dedicated to systems [...] There are two absolute standouts of this book that I haven’t encountered in many other books before. There are two successive chapters on ‘Setting Up and Equipping a Reptile Practice’ and ‘The Reptile Consultation’, which provide beautiful guiding principles for getting into this growing field, right down to marketing of the service. The second standout is chapter 17: ‘Differential Diagnoses: A Problem-Based Approach’. The chapter runs for 36 pages and contains nothing but lists of differentials for common presenting signs of the four major reptile taxa: snakes, lizards, chelonians and crocodilians. Every major disease text should contain such a chapter and I cannot wait until the authors release the searchable app for this. [...] The text probably won’t contain the level of information a reptilian disease researcher might covet, but would be perfect for the general practitioner looking to start in reptiles, the general practitioner faced with a single question from a keen owner, the already established reptile expert and most certainly would be perfect for those veterinarians embarking upon membership examinations to Australian and New Zealand College in exotic pet medicine.”Australian Veterinary Journal Volume 97 No 10, October 2019Table of ContentsList of Contributors xi Preface xv 1 Taxonomy and Introduction to Common Species 1Bob Doneley 2 Anatomy and Physiology of Reptiles 15Bairbre O’Malley 3 Behaviour in the Wild and in Captivity 33Robert Johnson 4 Husbandry and Nutrition 45Michelle Kischinovsky, Aidan Raftery and Shivananden Sawmy 5 Enclosure Design 61Michael McFadden, Deborah Monks, Bob Doneley and Robert Johnson 6 Lighting 75Frances M. Baines 7 Reproduction 91Timothy J. Portas 8 Reptile Paediatrics 105Deborah Monks and Bob Doneley 9 Setting Up and Equipping a Reptile Practice 115Bob Doneley, Shane Simpson, Angela M. Lennox and John Chitty 10 The Reptile Consultation 125Bob Doneley and Brendan Carmel 11 Diagnostic Testing 135Rachel E. Marschang, Frank Pasmans, Tim Hyndman, Mark Mitchell and An Martel 12 Diagnostic Imaging 145Zden¨§k Knotek, Shane Simpson and Paolo Martelli 13 Clinical Techniques and Supportive Care 159Kimberly Vinette Herrin 14 Reptile Pharmacology 175Tim Hyndman 15 Nutritional and Metabolic Diseases 185Brendan Carmel and Robert Johnson 16 Infectious Diseases and Immunology 197Tim Hyndman and Rachel E. Marschang 17 Differential Diagnoses: A Problem©\Based Approach 217Helen McCracken, Brendan Carmel, John Chitty, Bob Doneley, Robert Johnson, Angela M. Lennox, Deborah Monks and Annabelle Olsson 18 Disorders of the Integument 255Linda Vogelnest 19 Diseases of the Gastrointestinal System 273Robert Johnson and Bob Doneley 20 Diseases of the Cardiovascular System 287Tegan Stephens and Alex Rosenwax 21 Diseases of the Respiratory System 299Melinda L. Cowan 22 Disorders of the Reproductive System 307Timothy J. Portas 23 Diseases of the Urinary Tract 323Peter Holz 24 Diseases of the Nervous System 331Hamish Baron and David N. Phalen 25 Disorders of the Musculoskeletal System 345Adolf K. Maas 26 Diseases of the Organs of Special Senses 357Alex Rosenwax and Tegan Stephens 27 Analgesia and Anaesthesia 369Annabelle Olsson and Mark Simpson 28 Surgery 383Zden¨§k Knotek and Stacey Leonatti Wilkinson 29 Turtle Shell Repair 397Jane Roffey and Sasha Miles 30 Necropsy 409Catherine M. Shilton 31 Reptile Parasitology in Health and Disease 425Jan Šlapeta, David Modrý, Robert Johnson 32 Nursing the Reptile Patient 441Gary Fitzgerald and Emma Whitlock 33 Euthanasia 449Tim Hyndman Appendix 1: Formulary 453 Appendix 2: Reference Intervals for Commonly Kept Reptile Species 473 Index 481

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Book SynopsisAtlas of Clinical Imaging and Anatomy of the Equine Head presents a clear and complete view of the complex anatomy of the equine head using cross-sectional imaging.Trade Review"Atlas of Clinical Imaging and Anatomy of the Equine Head is a comprehensive reference of the cross-sectional anatomy of the head of equids that features photographs of gross sections, CT images, and MRI scans of the head in transverse, sagittal, and dorsal planes. The photographs of gross-section preparations are excellent, and most anatomic features are readily identifiable. Furthermore, the anatomic labels are exhaustive"...... "The provided images should enable readers to recognize most anatomic structures on other MRI pulse sequences"......"In addition to the anatomic atlas, the book contains a well-written introduction that briefly explains the basic principles of CT and MRI interpretation and considerations for image acquisition. Readers unfamiliar with CT and MRI will gain a superficial understanding of what influences tissue appearance in images acquired by the use of those modalities, and appropriate references are provided for readers who wish to learn more. This book will be useful for radiologists, surgeons, internists, and other practitioners who occasionally need to acquire diagnostic images of the heads of horses" (Reviewed by Derek Cissell, VMD, PhD, DACVR, University of California-Davis, Davis, Calif 15th June 2017 AVMA)Table of ContentsIntroduction: General Presentation of Atlas, vi 1 Overview of CT and MRI of the Equine Head, 1 2 Clinical and Surgical Anatomy of the Equine Head: Transverse Sections, 9 3 Clinical and Surgical Anatomy of the Equine Head: Sagittal Sections, 85 Brain sagittal close-up, 100 4 Clinical and Surgical Anatomy of the Equine Head: Dorsal Sections, 115 Glossary, 143 References, 145 Index, 147

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Book SynopsisBlackwell's Five-Minute Veterinary Consult Clinical Companion: Small Animal Emergency and Critical Care, Second Edition provides essential information about treating medical emergencies using a quick-reference format ideal for the fast-paced emergency setting. Offers fast access to important information during a small animal emergency Presents topics alphabetically with identically formatted topics for ease of use Adds information on 25 new diseases and updates throughout, plus updated references and more information on drugs available outside the US Features color photographs to depict the diseases and conditions discussed Includes access to a companion website with client education handouts to download and use in practice Trade Review"The second edition of Blackwell's Five-Minute Veterinary Consult Clinical Companion: Small Animal Emergency and Critical Care is a great reference for emergency doctors, interns, and residents. It contains easily accessible information, excellent photographs, and diagrams regarding conditions commonly and uncommonly seen in emergency-critical care practice. The book is well organized and contains many excellent etiology and pathophysiology tips." JAVMA, January 2018Table of ContentsContributor List ix Preface xv About the Companion Website xvi Chapter 1 Acetaminophen Toxicity 1 Chapter 2 Acute Respiratory Distress Syndrome 9 Chapter 3 Anterior Uveitis 17 Chapter 4 Anticoagulant Rodenticide Toxicity 25 Chapter 5 Arterial Thromboembolism 31 Chapter 6 Atrial Fibrillation and Atrial Flutter 42 Chapter 7 Atrial Standstill 49 Chapter 8 Atrioventricular Block 55 Chapter 9 Blood Transfusion Reaction 64 Chapter 10 Brachial Plexus Injury 71 Chapter 11 Bromethalin Rodenticide Toxicity 77 Chapter 12 Bundle Branch Block – Left 84 Chapter 13 Bundle Branch Block – Right 88 Chapter 14 Canine Distemper 93 Chapter 15 Cardiopulmonary Arrest and Cardiopulmonary Resuscitation 100 Chapter 16 Cholecalciferol – Rodenticide Toxicity 109 Chapter 17 Chylothorax 117 Chapter 18 Coonhound Paralysis 125 Chapter 19 Diabetic Ketoacidosis 131 Chapter 20 Diaphragmatic Hernia 138 Chapter 21 Disorders of Chloride 146 Chapter 22 Disorders of Phosphorus 150 Chapter 23 Disorders of Sodium 155 Chapter 24 Drowning and Submersion Injury 161 Chapter 25 Dystocia and Uterine Inertia 169 Chapter 26 Electric Cord Injury 177 Chapter 27 Epistaxis 183 Chapter 28 Esophageal Foreign Body 191 Chapter 29 Ethylene Glycol Toxicity 197 Chapter 30 Feline Bronchitis 203 Chapter 31 Feline Infectious Peritonitis 214 Chapter 32 Feline Leukemia Virus Infection 221 Chapter 33 Feline Lower Urinary Tract Disease 229 Chapter 34 Feline Panleukopenia 238 Chapter 35 Gastric Dilation-Volvulus Syndrome 245 Chapter 36 Gastrointestinal Foreign Body/Obstruction 254 Chapter 37 Glaucoma 262 Chapter 38 Heat Stroke and Heat-Induced Illness 272 Chapter 39 Hemoabdomen 283 Chapter 40 Hepatic Encephalopathy 291 Chapter 41 Hyperglycemia 300 Chapter 42 Hyperkalemia 306 Chapter 43 Hyperosmolarity 312 Chapter 44 Hypertension 318 Chapter 45 Hypertrophic and Restrictive Cardiomyopathy 331 Chapter 46 Hyphema 339 Chapter 47 Hypoadrenocorticism 346 Chapter 48 Hypokalemia 352 Chapter 49 Hypotension 358 Chapter 50 Hypothermia 364 Chapter 51 Hypoxemia 370 Chapter 52 Idioventricular Dysrhythmias 377 Chapter 53 Immune-Mediated Hemolytic Anemia 382 Chapter 54 Immune-Mediated Thrombocytopenia 394 Chapter 55 Intussusception 405 Chapter 56 Ivermectin Toxicity 410 Chapter 57 Lily Toxicity 415 Chapter 58 Lower Urinary Tract Infections – Canine and Feline 421 Chapter 59 Macadamia Nut Toxicity 434 Chapter 60 Magnesium Disorders 437 Chapter 61 Metabolic Acidosis 445 Chapter 62 Metabolic Alkalosis 452 Chapter 63 Metaldehyde Toxicity 457 Chapter 64 Murmurs 462 Chapter 65 Mycotoxins – Aflatoxins 468 Chapter 66 Mycotoxins – Tremorgens 474 Chapter 67 NSAID Toxicosis 479 Chapter 68 Organophosphate Intoxication 486 Chapter 69 Otitis Media and Otitis Interna – Canine 493 Chapter 70 Paraphimosis 506 Chapter 71 Parvoviral Enteritis – Canine 509 Chapter 72 Pericardial Effusion 517 Chapter 73 Pleural Effusion 533 Chapter 74 Pneumonia – Aspiration 542 Chapter 75 Pneumonia – Bacterial 549 Chapter 76 Pneumothorax 557 Chapter 77 Proptosis 568 Chapter 78 Pulmonary Arterial Hypertension 576 Chapter 79 Pulmonary Contusions 587 Chapter 80 Pulmonary Edema – Cardiogenic 593 Chapter 81 Pulmonary Edema – Noncardiogenic 603 Chapter 82 Pulmonary Thromboembolism 611 Chapter 83 Pyometra 620 Chapter 84 Pyothorax 628 Chapter 85 Raisin and Grape Toxicity 637 Chapter 86 Retinal Detachment 644 Chapter 87 Schiff-Sherrington 651 Chapter 88 Scleral and Corneal Lacerations 654 Chapter 89 Seizures 663 Chapter 90 Septic Peritonitis 672 Chapter 91 Serotonin Syndrome 682 Chapter 92 Shock – Cardiogenic 688 Chapter 93 Shock – Distributive 695 Chapter 94 Smoke Inhalation 703 Chapter 95 Snake Bite – Coral Snakes 711 Chapter 96 Snake Bite – Pit Vipers 721 Chapter 97 Spider Bite – Black Widow 732 Chapter 98 Spider Bite – Brown Spiders 738 Chapter 99 Spinal Fracture 750 Chapter 100 Spinal Shock 757 Chapter 101 Splenic Torsion 761 Chapter 102 Supraventricular Tachycardia 766 Chapter 103 Syncope 773 Chapter 104 Tick Paralysis 780 Chapter 105 Tracheal Collapse 785 Chapter 106 Traumatic Myocarditis 791 Chapter 107 Urethral Obstruction – Canine 797 Chapter 108 Urethral Obstruction – Feline 805 Chapter 109 Urethral Prolapse 813 Chapter 110 Vaginal Hyperplasia/Prolapse 817 Chapter 111 Ventricular Dysrhythmias 822 Chapter 112 Vestibular Disease 827 Chapter 113 Vomiting/Hematemesis 835 Chapter 114 Von Willebrand Disease 843 Chapter 115 Zinc Toxicity 849 Index 855

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