Description
Book SynopsisNow in a revised edition,
Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
Trade Review"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011)
Table of ContentsCoauthors. Preface.
1 Introduction.
2 Principles of Drug Movement in the Body.
3 Quantitative Structure–Permeability Relationships (Xin-Rui Xia).
4 Absorption.
5 Distribution (with Jennifer Buur).
6 Renal Elimination.
7 Hepatic Biotransformation and Biliary Excretion (Ronald Baynes).
8 Compartmental Models.
9 Noncompartmental Models.
10 Nonlinear Models.
11 Physiological Models (Teresa Leavens).
12 Dosage Regimens.
13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (Pierre-Louis Toutain).
14 Study Design and Data Analysis. (Jason Chittenden).
15 Bioequivalence Studies (Marilyn Martinez).
16 Population Pharmacokinetic Models (Jason Chittenden).
17 Dosage Adjustments in Disease States (Jennifer Davis).
18 Interspecies Extrapolations.
19 Tissue Residues and Withdrawal Times (Sharon Mason).
Index.
