Pharmaceutical chemistry and technology Books
Authors' Tranquility Press Emerging Technologies In Pharmaceuticals
Book Synopsis
£44.86
Springer Nature Switzerland AG Handbook of Space Pharmaceuticals
Book SynopsisThis handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation.As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.Table of ContentsSection I: Principles of Pharmaceuticals.- Section II: Effects of Spaceflight on Human Physiology and its Consequences on Drug Treatment.- Section III: Model Organisms for Pharmaceutical Research in Space.- Section IV: Simulated Microgravity for Pharmaceutical Research.- Section V: Translating Knowledge from Spaceflight Research to Earth Applications.- Section VI: Nutritional and Alternative Approaches to Treatment in Space.
£522.49
Springer Nature Switzerland AG Proteinkinase Inhibitors
Book SynopsisThis book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.Table of ContentsProteinKinase-Inhibitors: A Story of Success.- Function, Structure and Topology of Proteinkinases.- Molecular Modelling.- Case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR.- Achieving high level of selectivity for kinase inhibitors.- Inhibitors of c-Jun N-terminal kinase 3.- Exploiting kinase inhibitors for cancer treatment - An Overview of Clinical Results and Outlook.- Covalent Janus Kinase 3 Inhibitors.
£104.49
Springer Nature Switzerland AG Proteinkinase Inhibitors
Book SynopsisThis book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.Table of ContentsProteinKinase-Inhibitors: A Story of Success.- Function, Structure and Topology of Proteinkinases.- Molecular Modelling.- Case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR.- Achieving high level of selectivity for kinase inhibitors.- Inhibitors of c-Jun N-terminal kinase 3.- Exploiting kinase inhibitors for cancer treatment - An Overview of Clinical Results and Outlook.- Covalent Janus Kinase 3 Inhibitors.
£104.49
Springer International Publishing AG Principles and Practices of Lyophilization in
Book SynopsisThe biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing. Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals” comprised of nine chapters written by experts and including case studies.Table of Contents1. Overview of Freeze Drying2. Characterization and Determination of Freeze Drying Properties of Frozen Formulations- Case Studies3. Beyond pH: Acid/base relationships in frozen and freeze-dried pharmaceuticals4. Concepts and Strategies in the Design of Formulation for Freeze Drying5. Formulation Design for Freeze Drying - Case studies of Stabilization of Proteins6. Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product7. Freeze-drying of thermosensible pharmaceuticals with organic co-solvent + water formulations8. Primary container closure system selection for lyophilized drug products9. Vial Breakage During Lyophilization10. The Nucleation of Ice11. Stresses, Stabilization, and Recent Insights in Freezing of Biologics12. Lyophilization Process Understanding and Scale-up using ab initio Vial Heat Transfer Modeling13. Secondary drying: Challenges and Considerations14. Design and Process Considerations in Spray Freeze Drying15. LyoPRONTO: Deterministic and Probabilistic Modeling. Tutorial and Case Study16. Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations17. Design of Moisture Studies for a Lyophilized Product18. Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products19. Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process20. Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection21. Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer22. Overview of Heat and Mass Transfer Modeling in Lyophilization to Create Design Spaces and Improve Process Analytical Tool (PAT) Capability23. Application of QbD elements in the Development and Manufacturing of a Lyophilized product.- Characterization of Freeze Dryer24. Characterization of Freeze Dryer25. Scale-up and Technology Transfer of a Lyophilization Process26. Lyophilization Validation: Process Design and Modeling27. Lyophilization Validation: Process Qualification and Continued Process Verification28. Homogeneity Assessment of Lyohilized Biological Drug Products During Process Performance Qualification29. Informed Manufacturing through the use of Big Data Analytics for Freeze Drying Process & Equipment30. Multivariate Analysis for Process Understanding, Continuous Process Verification and Condition Monitoring of Lyophilization Processes31. Lyophilized Drug Product Cake Appearance: What Is Acceptable?
£125.99
Springer International Publishing AG Pharmaceutical Biotechnology: Fundamentals and
Book SynopsisThis introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology. Table of ContentsMolecular Biotechnology.- Biophysical and biochemical analysis of recombinant proteins.- Production and downstream processing of biotech products.- Formulation of biotech products, including biopharmaceutical considerations.- Pharmacokinetics and pharmacodynamics of peptide and protein drugs.- Immunogenicity of pharmaceutical proteins.- General considerations of monoclonal antibodies from structure to therapeutic application.- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques.- Dispensing biotechnology products: handling, professional education and product information.- Economic considerations in medical biotechnology.- Regulatory framework for biosimilars.- Vaccines.- Oligonucleotides and siRNA.- Gene therapy.- Stem cell technology.- Therapeutic Applications.-Endocrinology.- Insulin.- Follicle-stimulating hormone.- Growth hormone.- Cardiovascular and Respiratory Applications.- Recombinant coagulation factors and thrombolytics.- Recombinant human deoxyribonuclease.- Oncology.- Monoclonal antibodies in oncology .- Hematopoetic growth factors.- Inflammation and Immunemodulation.- Monoclonal antibodies in transplantation.- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy.- Interferons and interleukins.- Anti-infectious diseases.- Monoclonal antibodies.- Enzyme replacement therapy.
£67.49
de Gruyter Regulated Cannabis and Hemp Market Navigation
Book Synopsis
£72.00
De Gruyter Active Pharmaceutical Ingredient Manufacturing: Nondestructive Creation
Book SynopsisThe book reviews the history of current brand and generic business in pharmaceuticals manufacturing practices. Based on examples, the reader can interpolate, extrapolate and exploit mutual behavior (physical and chemical properties) of chemicals to design and commercialize processes that fulfi ll the demands, also manipulate chemical unit processes and unit operations to reduce/minimize effl uents and lower environmental impact i.e. reduce global warming. Readers will be able to simplify process development, design and commercialize economic manufacturing processes.
£75.05
De Gruyter Product-Driven Process Design: From Molecule to Enterprise
Book SynopsisProduct-driven process design – from molecule to enterprise provides process engineers and process engineering students with access to a modern and stimulating methodology to process and product design. Throughout the book the links between product design and process design become evident while the reader is guided step-by-step through the different stages of the intertwining product and process design activities. Both molecular and enterprise-wide considerations in design are introduced and addressed in detail. Several examples and case studies in emerging areas such as bio- and food-systems, pharmaceuticals and energy are discussed and presented. This book is an excellent guide and companion for undergraduate, graduate students as well as professional practitioners.
£72.68
de Gruyter Catalysis for Fine Chemicals
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£65.60
De Gruyter Natural Poisons and Venoms
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£58.40
de Gruyter Pharmaceutical Chemistry
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£54.75
De Gruyter Industrial Pharmaceutical Chemistry: Product Quality
Book SynopsisThis book discusses the effects of prolonged hypoventilation, or a pulmonary condition on hypoxia, and hypercapnia, its effect on the formation of some joint diseases, and the types of natural medicine used in the treatment of each joint disease. You will also find methods used to calculate thermodynamic parameters. You can also learn optimized structures for these chemical compounds. The book includes a listing of the thermodynamic table for literature values for standard enthalpy of formation, and C-H and O-H Bond dissociation energizes energies for some chemical compounds; simple multi-fluorinated organic alcohols.
£60.80
de Gruyter Chemistry of Nucleic Acids
Book Synopsis
£73.80
de Gruyter Organic Chemistry 25 MustKnow Classes of Organic
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£56.52
De Gruyter Bioactive ThreeMembered Heterocycles
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£139.17
De Gruyter Bioactive FourMembered Heterocycles
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£139.17
De Gruyter Carbohydrates in Chemistry and Biology
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£131.85
de Gruyter Medicinal and Aromatic Plants
£78.00
Walter de Gruyter Mein Mikrobiom Meine Gene Und Ich
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£35.96
de Gruyter Ergänzungen
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£134.09
de Gruyter Stabilität Und Aufbewahrung Von Arzneimitteln
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£134.09
de Gruyter Metrologie in Der Arzneimittelkontrolle
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£134.09
de Gruyter Anorganische Prüfkomponenten in Der
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£134.09
de Gruyter Blutgas Und SäurenBasenAnalytische Prüfmethoden
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£134.09
de Gruyter Qualitätskontrolle Und Qualitätssicherung in Der
Book Synopsis
£134.09
de Gruyter Immunhämatologische Prüfmethoden in Der
Book Synopsis
£134.09
de Gruyter Maximaldosen Und Rezeptpflicht Von Arzneimitteln
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£134.09
de Gruyter Radioaktive Arzneimittel
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£134.09
de Gruyter Über Die Anwendung Der IrSpektroskopie in Der
Book Synopsis
£134.09
de Gruyter Über Die Anwendung Der UvVisSpektroskopie in Der
Book Synopsis
£134.09
de Gruyter Maximaldosen Rezeptpflicht Und Synonyme Der Im
Book Synopsis
£134.09
de Gruyter Deutsches Arzneibuch
Book Synopsis
£134.09
Wiley-VCH Verlag GmbH Computational Drug Discovery, 2 Volumes: Methods
Book SynopsisComputational Drug Discovery A comprehensive resource that explains a wide array of computational technologies and methods driving innovation in drug discovery Computational Drug Discovery: Methods and Applications (2 volume set) covers a wide range of cutting-edge computational technologies and computational chemistry methods that are transforming drug discovery. The book delves into recent advances, particularly focusing on artificial intelligence (AI) and its application for protein structure prediction, AI-enabled virtual screening, and generative modeling for compound design. Additionally, it covers key technological advancements in computing such as quantum and cloud computing that are driving innovations in drug discovery. Furthermore, dedicated chapters that addresses the recent trends in the field of computer aided drug design, including ultra-large-scale virtual screening for hit identification, computational strategies for designing new therapeutic modalities like PROTACs and covalent inhibitors that target residues beyond cysteine are also presented. To offer the most up-to-date information on computational methods utilized in Computational Drug Discovery, it covers chapters highlighting the use of molecular dynamics and other related methods, application of QM and QM/MM methods in computational drug design, and techniques for navigating and visualizing the chemical space, as well as leveraging big data to drive drug discovery efforts. The book is thoughtfully organized into eight thematic sections, each focusing on a specific computational method or technology applied to drug discovery. Authored by renowned experts from academia, pharmaceutical industry, and major drug discovery software providers, it offers an overview of the latest advances in computational drug discovery. Key topics covered in the book include: Application of molecular dynamics simulations and related approaches in drug discovery The application of QM, hybrid approaches such as QM/MM, and fragment molecular orbital framework for understanding protein-ligand interactions Adoption of artificial intelligence in pre-clinical drug discovery, encompassing protein structure prediction, generative modeling for de novo design, and virtual screening. Techniques for navigating and visualizing the chemical space, along with harnessing big data to drive drug discovery efforts. Methods for performing ultra-large-scale virtual screening for hit identification. Computational strategies for designing new therapeutic models, including PROTACs and molecular glues. In silico ADMET approaches for predicting a variety of pharmacokinetic and physicochemical endpoints. The role of computing technologies like quantum computing and cloud computing in accelerating drug discovery This book will provide readers an overview of the latest advancements in Computational Drug Discovery and serve as a valuable resource for professionals engaged in drug discovery.Table of ContentsVolume 1 Preface xv Acknowledgments xix About the Editors xxi Part I Molecular Dynamics and Related Methods in Drug Discovery 1 1 Binding Free Energy Calculations in Drug Discovery 3Anitade Ruiter and Chris Oostenbrink 2 Gaussian Accelerated Molecular Dynamics in Drug Discovery 21Hung N. Do, Jinan Wang, Keya Joshi, Kushal Koirala, and Yinglong Miao 3 MD Simulations for Drug-Target(Un)binding Kinetics 45Steffen Wolf 4 Solvation Thermodynamics and its Applications in Drug Discovery 65Kuzhanthaivelan Saravanan and Ramesh K. Sistla 5 Site-Identification by Ligand Competitive Saturation as a Paradigm of Co-solvent MD Methods 83Asuka A. Orr and Alexander D. MacKerell Jr. Part II Quantum Mechanics Application for Drug Discovery 119 6 QM/MM for Structure-Based Drug Design: Techniques and Applications 121Marc W. van der Kamp and Jaida Begum 7 Recent Advances in Practical Quantum Mechanics and Mixed-QM/MM-Driven X-Ray Crystallography and Cryogenic Electron Microscopy (Cryo-EM) and Their Impact on Structure-Based Drug Discovery 157Oleg Borbulevych and Lance M. Westerhoff 8 Quantum-Chemical Analyses of Interactions for Biochemical Applications 183Dmitri G. Fedorov Part III Artificial Intelligence in Pre-clinical Drug Discovery 211 9 The Role of Computer-Aided Drug Design in Drug Discovery 213Stormvander Voort, Andreas Bender, and Bart A. Westerman 10 AI-Based Protein Structure Predictions and Their Implications in Drug Discovery 227Tahsin F. Kellici, Dimitar Hristozov, and Inaki Morao 11 Deep Learning for the Structure-Based Binding Free Energy Prediction of Small Molecule Ligands 255Venkatesh Mysore, Nilkanth Patel, and Adegoke Ojewole 12 Using Artificial Intelligence for de novo Drug Design and Retrosynthesis 275Rohit Arora, Nicolas Brosse, Clarisse Descamps, Nicolas Devaux, Nicolas Do Huu, Philippe Gendreau, Yann Gaston-Mathé, Maud Parrot, Quentin Perron, and Hamza Tajmouati 13 Reliability and Applicability Assessment for Machine Learning Models 299Fabio Urbina and Sean Ekins Volume 2 Preface xv Acknowledgments xix About the Editors xxi Part IV Chemical Space and Knowledge-Based Drug Discovery 315 14 Enumerable Libraries and Accessible Chemical Space in Drug Discovery 317Tim Knehans, Nicholas A. Boyles, and Pieter H. Bos 15 Navigating Chemical Space 337Akos Tarcsay, András Volford, Jonathan Buttrick, Jan-Constantin Christopherson, Máte Erdos, and Zoltán B. Szabó 16 Visualization, Exploration, and Screening of Chemical Space in Drug Discovery 365José J. Naveja, Fernanda I. Saldívar-González, Diana L. Prado-Romero, Angel J.Ruiz-Moreno, Marco Velasco-Velázquez, Ramón Alain Miranda-Quintana, and José L. Medina-Franco 17 SAR Knowledge Bases for Driving Drug Discovery 395Nishanth Kandepedu, Anil Kumar Manchala, and Norman Azoulay 18 Cambridge Structural Database (CSD)–Drug Discovery Through Data Mining & Knowledge-Based Tools 419Francesca Stanzione, Rupesh Chikhale, and Laura Friggeri Part V Structure-Based Virtual Screening Using Docking 441 19 Structure-Based Ultra-Large Virtual Screenings 443Christoph Gorgulla 20 Community Benchmarking Exercises for Docking and Scoring 471Bharti Devi, Anurag TK Baidya, and Rajnish Kumar PartVI In Silico ADMET Modeling 495 21 Advances in the Application of In Silico ADMET Models–An Industry Perspective 497Wenyi Wang, Fjodor Melnikov, Joe Napoli, and Prashant Desai Part VII Computational Approaches for New Therapeutic Modalities 537 22 Modeling the Structures of Ternary Complexes Mediated by Molecular Glues 539Michael L. Drummond 23 Free Energy Calculations in Covalent Drug Design 561Levente M. Mihalovits, György G. Ferenczy, and György M. Keseru Part VIII Computing Technologies Driving Drug Discovery 579 24 Orion A Cloud-Native Molecular Design Platform 581Jesper Sorensen, Caitlin C. Bannan, Gaetano Calabrò, Varsha Jain, Grigory Ovanesyan, Addison Smith, She Zhang, Christopher I. Bayly, Tom A. Darden, Matthew T. Geballe, David N. LeBard, Mark McGann, Joseph B. Moon, Hari S. Muddana, Andrew Shewmaker, Jharrod LaFon, Robert W. Tolbert, A. Geoffrey Skillman, and Anthony Nicholls 25 Cloud-Native Rendering Platform and GPUs Aid Drug Discovery 617Mark Ross, Michael Drummond, Lance Westerhoff, Xavier Barbeu, Essam Metwally, Sasha Banks-Louie, Kevin Jorissen, Anup Ojah, and Ruzhu Chen 26 The Quantum Computing Paradigm 627Thomas Ehmer, Gopal Karemore, and Hans Melo Index 679
£172.44
Harwood-Academic Publishers Advances in Oncology
Book SynopsisFirst Published in 1988. This is a collection of the Proceedings of a course held at the International School of Medical Sciences Ettore Majorana Centre for Scientific Culture, Italy 5-13 September 1986.Table of ContentsPreface, Biological Aspects, Clinical Aspects, Conclusions
£142.50
Harwood-Academic Publishers Growth In Childhood
Book SynopsisFirst Published in 1989 this is a collection of essays based on a series of lectures given at a symposium held at the University of Southampton Medical School from eight experts in the field of growth failure. Interest in growth hormone, its regulation and its therapeutic use has grown enormously since the introduction of genetically engineered growth hormone in 1985. The very pratcial probelms of measuring growth, the physiology of growth failure and its epidemiology are followed by a richly illustrated chapter on the spectrum of diseases assciated with short stature and an expert with extensive experience in the field looks at the application of growth hormone therapy. Table of ContentsGrowth measurement, John Buckler; the physiology of growth hormone regulation, Richard Ross and Michael Besser; epidemiology of growth failure, Michael Parkin; the clinical spectrum, Peter Betts; growth hormone therapy, Charles Brook; growth at puberty, Martin Savage; human growth hormone - its current implications and future applications, Brian Gennery and Stephen Wise; growth hormone - a consumer's viewpoint, Tam Fry.
£80.74
Harwood-Academic Publishers Growth and Hyperplasia of Cardiac Muscle Cells
Book SynopsisFirst Published in 1991. This Volume three of a set of a monograph series publishing versions of some of the research reviewed in its companion series, Section A (Cardiology Reviews) of Soviet Medical Reviews.Table of ContentsPreface PART I NORMAL GROWTH OF DEVELOPING CARDIAC MUSCLE Chapter 1 Differentiation of Cardiomyocytes Chapter 2 Reproduction of Cardiac Myocytes Developing In Vivo and its Relation to Processes of Differentiation PART 11 CELLULAR ASPECTS OF REGENERATIVE PROCESSES AND HYPERPLASIA IN THE INJURED AND OVERLOADED MYOCARDIUM Chapter 3 Regenerative Processes in the Myocardium of Cold-B1ooded Animals Chapter 4 Proliferation of Cardiac Myocytes in the Injured and Overloaded Myocardium du ring Early Ontogenesis of Warm-Blooded Animals and Man Reactive hyperplasia of cardiomyoeytes of the injured heart of embryos and neonatal animals Chapter 5 Regenerative Possibilities of the Ventricular Myocardium of Adult Mammals Chapter 6 Unusual Proliferative Behavior of Adult Mammalian Atrial Cardiomyocytes Chapter 7 On the Possibility of Reactivation of Proliferative Processes in Cardiomyocytes Of the Conducting System Chapter 8 A Paradoxical Capacity of Working Myocytes of the Overloaded Heart of Man and Primates for Polyploidization Chapter 9 Attempts to Stimulate Myocardial Regeneration PART III MODULATION OF PROCESSES OF CARDIOMYOCYTE DIFFERENTlATION AND PROLIFERATION IN VITRO AND IN TISSUE TRANSPLANTS Chapter 10 Modulations of Differentiation in Tissue Explants of the Myocardium In Vitra Chapter II Processes of Cardiomyocyte Proliferation and Differentiation in Cell Culture Chapter 12 Regenerative Morphogenesis du ring Auto- and Heterotransplantation of Myocardial Tissue Grafts
£308.75
CRC Press The Pharmaceutical Index: 2013 Worldwide NCEs
Book SynopsisAn ideal drug candidate should possess good pharmacological activity, absorption, distribution, metabolism, excretion and toxicity properties. Historically, there are around 6,000 drugs being used in humans and approximately 3,000 still in clinical use, not including herbal medicines. This Pharmaceutical Index series focuses on the profiles of 500 pharmaceutically marketed products from the past two decades. Professor Dr. K. Barry Sharpless is Honorary Editor-in-Chief of this first Index by Pharmacodia. The volume includes 24 NCEs worldwide approved drugs in 2013. Pharmacodia plan to publish two further volumes which will feature 2014 NCEs (32 drugs) and 2015 NCEs (25 drugs).
£380.00
CBS Publishers & Distributors Practical Pharmaceutical Chemistry
Book Synopsis
£13.12
River Publishers Pharmaceutical industry 4.0: Future, Challenges &
Book SynopsisThe pharmaceutical industry is on the cusp of a new age, with the need for personalized therapy, more complex production processes, smaller batch sizes and rising manufacturing costs. It is necessary to continuously adapt to the rapidly changing environment using novel technology and improved operational efficiency and flexibility. To achieve this, intelligent manufacturing seems to be a definite answer. Pharma 4.0 is a framework for adapting digital strategies to the unique contexts of pharmaceutical manufacturing. This book provides a deep insight into key technologies that will modernize pharmaceutical manufacturing and facilitate digital transformation. Throughout the book we discuss technologies, application and challenges for applying digital technology in pharmaceutical industry, including: • Focus on an overview of Industry 4.0 and its application in the pharmaceutical field• Most recent advances in the pharmaceutical industry• Understanding the concepts of emerging technology trends for drug discovery.Table of Contents1. Digitalization in the Pharmaceutical Industry: Prioritization Throughout Digital Transformation 2. Applications of Industry 4.0 to the Pharmaceutical Sector 3. Blockchain in Pharmaceutical Industry: Opportunities and Challenges 4.Patient Monitoring using Blockchain 5. Potential of AI in Advancement of the Pharmaceutical Industry 6. Use of Artificial Intelligence and Robotics: Making the Drug Development Process Easier 7. Pharmaceutical Packaging: New Impulse Through Artificial Intelligence 8. Digital Assistant in Healthcare Systems: Application and Challenges 9. Deep Learning Techniques and Drug Release 10. Tissue Response Study Using Deep Learning Techniques 11. Issues and Challenges in Bioinformatics Tools for Clinical Trials 12. Advancement in Artificial Intelligence: Insights and Future Vision for Pharmacy Profession
£104.50
Taylor & Francis Ltd Basic Endocrinology: For Students of Pharmacy and
Book SynopsisThis textbook has been written primarily for undergraduate students of pharmacy, toxicology, and medicine who require a concise reference book on basic endocrine function and dysfunction.Table of ContentsPreface, Chapter 1: Introduction and General Principles, Chapter 2: The Hypothalamus and Pituitary, Chapter 3: The Adrenal Gland, Chapter 4: The Thyroid Gland, Chapter 5: Endocrine Secretions of the Pancreas, Chapter 6: The Gonads and Reproduction, Chapter 7: The Parathyroid Glands, Vitamin D and Hormonal Control of Calcium Metabolism, Abbreviations list, UK/USA spelling, Index
£46.54
Taylor & Francis Ltd Submicron Emulsions in Drug Targeting and
Book SynopsisIt is anticipated that submicron emulsion and lipid suspension will find numerous and novel medical applications in the near future. The purpose of this multi-authore book is to provide the reader with an up-to-date general overview of submicron emulsions and lipid suspensions (solid lipid nanoparticles) as well as to emphasize the various methods of preparation, characerization, evaluation and potential applications in various therapeutic areas.Leading authors have contributed to this unique book which contains all state of the art and detailed knowledge related to the physico-chemical, pharmaceutical and medical aspects of these most interesting but complex dosage forms, thus making this information easily available to the reader. This book will be of interest to scientists working in the field of drug delivery and targeting in universities as well as in the pharmaceutical, food, cosmetic, veterinary and chemical industries.Table of Contents1. Introduction and Overview Part 1. Intravenous Fat Emulsions 2. Perspectives on the Use of Intravenous Lipid Emulsions in Man 3. Particle-Sizing Technologies for Submicron Emulsions 4. Biofate of Fat Emulsions Part 2. Submicron Emulsions as Therapeutic Delivery Systems 5. Design and Evaluation of Submicron Emulsions as Colloidal Drug Carriers for Intravenous Administration 6. Submicron Emulsions as Drug Carriers for Tropical Administration 7. Emulsions of Supercooled Melts - A Novel Drug Delivery System 8. Submicron Lipid Suspensions (Solid Lipid Nanoparticles) Versus Lipid Nanoemulsions: Similarities and Differences 9. Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery Part 3. Perfluorochemical Submicron Emulsions 10. The Design and Engineering of Oxygen-Delivering Fluorocarbon Emulsions
£199.50
Taylor & Francis Ltd Laparoscopic Hernia Repair
Book SynopsisLaparoscopy is increasingly being used as an alternative to more invasive surgical techniques. This book details newly revealed anatomical dynamics of the lower abdominal wall and introduces the reader to laparoscopic repair of the inguinal hernia.Table of Contents1. Historical Perspective 2. Surgical Anatomy of the Inguinal Region 3. Equipment and Set-Up for Laparoscopic Hernia Repair 4. Laparoscopic Transabdominal Preperitoneal Repair: The Technique 5. Alternative Laparoscopic Techniques for Hernia Repair 6. Complications of Laparoscopic Hernia Repair: Problems and Solutions 7. Post Operative Care 8. Results of Laparoscopic Hernia Repair
£80.74
Swedish Pharmaceutical Press Drugs of Natural Origin: A Treatise of
Book SynopsisDrugs of Natural Origin is a unique multidisciplinary book suitable for undergraduate and graduate students and teachers in the area of natural product science, but also as a complementary book for disciplines like medicinal chemistry, biochemistry and pharmacology. The book can also serve society as a scientific source for the understanding of a sustainable use of natural products in the development of new drugs, scientifically based herbal remedies, and environmentally friendly biomolecules.During evolution, molecules have been developed for specific functions in nature. These bioactive substances have a potential as new drug candidates in drug development, but also as pharmacological tools, intermediates or templates for synthesis of drugs. This book deals with terrestrial and marine bioactive substances of plant, microbial or animal origin. The occurrence, biosynthesis, isolation, chemistry and medical use are described together with basic research strategies. An increased understanding of the medical importance of bioactive natural products has developed in society. Since the publication of the sixth edition, six years ago, considerable progress has been achieved in the study of biosynthetic pathways, mainly based on gene technology. The revolution in high-throughput sequencing technology has given an increasing access to microbial genome sequences, which opens up new possibilities in the discovery of novel bioactive natural products. This development is reflected in a substantial revision and expansion of the book, but also removal of some sections containing products remotely associated with drugs. The new book also contains description of novel drugs marketed since the publication of the previous edition, especially in the field of diabetes, cancer and infection.
£171.00
IAEA Guidance for Preclinical Studies with
Book SynopsisPreclinical or nonclinical evaluation is an integral part of the development of any drug. The process of developing a new radiopharmaceutical includes rigorous testing before it can be cleared for use in humans. There must be in-depth characterization of its behaviour to assess its safety and suitability for the intended clinical application. This publication provides a baseline guide for preclinical evaluation of radiopharmaceuticals that will give its readers a general review of the requirements of a facility and insight into the various scientific activities that constitute this process. The principles and protocols discussed herein will provide guidelines for biological assessment of candidate compounds, which are consistent with the principles of good laboratory practices to generate valid nonclinical scientific data towards approval for clinical translation. This publication is intended not only for researchers engaged in radiopharmaceutical development, but also for the Member States planning to set up or upgrade facilities for radiopharmaceuticals' research.
£38.90
World Scientific Publishing Co Pte Ltd Therapeutic Protein Targets For Drug Discovery
Book SynopsisThe book reviews the recent research advances and their outcomes in the areas of structural biology, bioinformatics, phytochemistry and drug discovery. Chapters in the book cover multidisciplinary research to understand the molecular mechanisms involved in protein-protein/ligand interactions. It employs an integrative approach to identify the therapeutic targets for HIV, and cancer, pathogen and viral infection pathways and the identification of their potential drug candidates. The book also provides examples of computational molecular dynamics simulations to understand the conformational changes in the molecules. Some chapters are focused on exploring potent bioactive compounds from natural sources.This book can serve as a single source that covers several interdisciplinary research fields which will be beneficial to Researchers and students in postgraduate studies.
£121.50
Springer Verlag, Singapore A Practical Guide to Pharmacological
Book SynopsisPharmacological biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook covers the whole range of experiments related to pharmacology. It also contains basic laboratory safety guidelines along with the basic calculations and formulas used in a laboratory. Each chapter starts with an introduction/theory into the basic approach followed by detailed methods sections with easy-to-follow protocols and comprehensive troubleshooting, calculations and possible questions for examination. The target group is researchers who are studying pharmacological biotechnology in the laboratory.Table of ContentsPart1.Introduction.- 1.1 Rules of laboratory safety in a pharmacology laboratory.- 1.2 Commom instruments and their uses used in a pharmacology laboratory.- Part2.General aspects of Pharmacology laboratory.- 2.1 Safety and Risk assessment.- 2.2 Use and Handling of laboratory animals.- 2.3 Experimental design.- 2.4 Essential statistics.- 2.5 Cumulative Dose Response Curve.- 2.6 Toxicology.- 2.7 Basic instruments and techniques in Pharmacology Laboratory .- Part3.Isolated tissues and organs.- 3.1 Basic instruments used for isolated tissue experiments.- 3.2 Organ baths.- 3.3 Smooth muscle preparations.- 3.4 Skeletal muscle preparations.- 3.5 Cardiac muscle preparations.- Part4.Isolated tissues for screening of drugs.- 4.1 Evaluation of antidiabetic agents.- 4.2 Evaluation of antidepressants.- 4.3 Evaluation of antihypertensive agents.- 4.4 Evaluation of antiulcer agents.- 4.5 Evaluation of hepatotoxicity.- 4.6 Evaluation of Antioxidant agents.- 4.7 Evaluation of local anaesthetics.- Part5.Genotoxicity and Toxicological studies.- 5.1 The Mouse Lymphoma Assay.- 5.2 The Comet Assay.- 5.3 In vitro Genotoxicity assay.- 5.4 In vitro Teratogenicity Testing.- 5.5 Histopathological studies of animal tissues.- 5.6 Drug poisoning.- Part6.Experimental Animal studies.- 6.1 Pyrogen testing.- 6.2 Collecting blood from mice.- 6.3 Studies on different parameters of blood.- 6.4 Experiment on central nervous system.- 6.5 Evaluation on cardiovascular system.- 6.6 Experiments on GI tract.- Part7.Clinical trials.- 7.1 Clinical Pharmacology and its genesis.- 7.2 National and International agencies and their role in Clinical pharmacology.- 7.3 Stages in drug development and clinical trials.- 7.4 Ethics in Clinical research.- 7.5 Safety assessment in Clinical trials.- Part8.IPR and ethics in animal studies.- 8.1 Intellectual property rights and its different categories.- 8.2 Importance of IPR in drug development.- 8.3 Patenting cells, cell lines and animals.- 8.4 Ethics in laboratory animal studies .- 8.5 Risk assessment and management.- 8.6 Good laboratory practices.
£52.49
Springer Verlag, Singapore Middle Molecular Strategy: Flow Synthesis to
Book SynopsisThis book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science. Table of ContentsPart I: Development of bio-functional middle molecules.- 1. Introduction.- 2. Total Synthesis, Biological Evaluation and 3D Structural Analysis of Cyclodepsipeptide Natural Products.- 3. Development of the Middle-size Molecules for Alkylation to Higher-Order Structures of Nucleic Acids.- 4. In Situ Synthesis of Glycoconjugates on Cell Surface: Selective Cell Imaging Using Low-Affinity Glycan Ligands.- 5. Assembled mid-sized agents that control intracellular protein-protein interactions.- 6. Macrocyclic mid-sized peptides with new chemical modalities.- Part II: Achievement of highly efficient synthesis of bioactive middle molecules.- 7. Enantioselective Total Synthesis of Cotylenin.- 8. Flow Chemistry for the Construction of Polycyclic Skeleton.- 9. Electrochemical Synthesis of Oligosaccharides as Middle-sized Molecules.- 10. Efficient Synthesis of Biologically Active Peptides based on Micro-flow Amide Bond Formation.- 11. Design and Concise De Novo Synthesis of Artemisinin Analogs.
£125.99
