Pharmaceutical chemistry and technology Books
Royal Society of Chemistry Basic Chemistry for Life Science Students and
Book SynopsisOrganic chemistry plays a vital role in the pharmaceutical industry. Knowledge of organic compounds is used to inform research and further the discovery and development of new medicines. Likewise, organic chemistry is fundamental to understanding biological reactions, mechanisms and all life sciences in general. Basic Chemistry for Life Science Students and Professionals is an ideal introduction to organic chemistry in the context of the life sciences and pharmacy related disciplines; utilising drug molecules to illustrate the chemical basis of their efficacy and interaction with biological targets. This book builds upon the basic concepts of organic chemistry to develop the reader’s understanding of the importance of organic chemistry to the life sciences from natural product sources, their synthesis, and approaches to drug discovery. Ideal for undergraduate students in the natural sciences, this book is also an excellent primer for postgraduates in a variety of disciplines including forensic science and allied-health programmes as well as professionals working in related fields seeking a comprehensive introduction to organic chemistry in the context of pharmaceuticals.Table of ContentsIntroduction to Organic Compounds and Covalent Bonding; Polarity of Bonds, Electronegativity, and Intermolecular Forces; Types of Organic Compounds, Nomenclature, and Basic Reactions: Alkanes and Cycloalkanes; Types of Organic Compounds, Nomenclature, and Basic Reactions: Alkenes, Cycloalkenes and Other Unsaturated Hydrocarbons; 5 Types of Organic Compounds, Nomenclature, and Basic Reactions: Functional Groups; Isomerism in Organic Compounds and Drug Molecules: Chemistry and Significance in Biology; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Amino Acids to Proteins; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Monosaccharides to Complex Carbohydrates; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Fatty Acids to Complex Lipids and Fat; Organic Macromolecules in Cellular Structures, Metabolism, and as Drugs: From Nucleotides to Nucleic Acids; Physicochemical Properties of Organic Compounds and Drug Molecules; Drug-Target Interactions; Structural Diversity and Sources of Drugs: From Nature to Synthetic and Recombinant DNA Technology
£42.75
Taylor & Francis Inc Implementing Quality in Laboratory Policies and
Book SynopsisIn order to gain accreditation, every laboratory must have a superior quality assurance program. The keys to a successful program are the operational and technical manuals and associated documents which define the program and its various components. Written by experts with global experience in setting up laboratories, Implementing Quality in Laboratory Policies and Processes: Using Templates, Project Management, and Six Sigma provides templates for the various policies, procedures, and forms that should be contained in the quality assurance, operational, and technical manuals of a laboratory seeking accreditation.Templates for the entire project life cycleThe book begins with a general introduction and overview of quality assurance and then moves on to cover implementation strategies. It contains best practices and templates for the project management of the design and implementation of the laboratory operational and teTrade Review...The authors do deserve applause for preventing repetitions, which are the norm, rather than exceptions, in books of this kind ... it is an important book which describes how quality has to be managed in any laboratory... —Puneet Setia and Avneesh Gupta, in Anil Aggrawal's Internet Journal of Forensic Medicine and Toxicology, Volume 11, Number 2, July - December 2010Table of ContentsINTRODUCTION. POLICY TEMPLATES. Quality Assurance Program Overview. Audits, Inspections and Reviews. Document Control. Equipment and Chemicals. Personnel. Evidence. Laboratory Information Management Systems. Issue Management. Forms. CRITERIA FILES. BIBLIOGRAPHY.
£832.50
Oxford University Press Drug Design and Development
Book SynopsisDrug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy. The book highlights why it is important that all practicing pharmacists, including those working in hospitals or high street stores, have a solid understanding of the process of the design and development of the drugs they interact with. It adopts an integrated approach, formulated to complement courses which are designed in line with the General Pharmaceutical Council''s new curriculum requirements. Furthermore, this is the only integrated textbook to consider both drug design and development within one volume. Throughout the book, the journey of the drug, from discovery to market, is presented in an integrated fashion, emphasising the interconnection of all the processes involved.Trade ReviewWell written text that guides students through the complex elements of the drug development process. It has a chemistry focus and utilises 'key points' to reinforce the important aspects at regular opportunities. * Dr James F. Brown, University of Portsmouth *Table of Contents1: Introduction Part 1 Drug targets 2: Receptors and signal transduction 3: Enzymes as drug targets 4: Nucleic acids and protein synthesis as drug targets 5: Other drug targets Part 2 Origins of drug molecules 6: Sources of lead compounds 7: Drug synthesis 8: Optimisation of lead compounds 9: Computer-aided drug design 10: Combinatorial chemistry and high-throughput screening 11: Biotechnology and biopharmaceuticals Part 3 Biological aspects of drug development 12: Drug metabolism 13: Pharmacogenetics and pharmacogenomics 14: Toxicity testing Part 4 Preformulation studies 15: Solubility and drug development 16: Solid state characteristics 17: Drug stability Part 5 Clinical research 18: Clinical research and its regulation 19: Design and management of clinical trials
£37.99
Indiana University Press Death to Beauty The Transformative History of
Book SynopsisTrade Review"A riveting text that bridges biography, history, and medicine, Death to Beauty is a must-read for anyone interested in the story of how Dr. Alan Scott, working almost independently and with few resources, transformed the world's deadliest toxin into a wonder drug that has not only become a multi-billion-dollar industry, but a medical and cultural phenomenon."—Dana Berkowitz, author of Botox Nation: Changing the Face of America"Expertly written and thoroughly researched, Dr. Helveston meticulously outlines the history of Botox and the pivotal role that Dr. Alan Scott played in bringing Botox safely to millions of people across the globe."—Christie L. Morse, MD, Concord Eye Center"Dr. Helveston has painstakingly researched the life and accomplishments of Alan B. Scott MD, one of the most brilliant minds in medicine and creator of botulinum toxin (Botox) for the treatment of many conditions. This book is a page burner, interesting, and still very thorough. I highly recommend it to clinicians and non-clinicians alike."—William Good, MD, Senior Scientist at Smith-Kettlewell Eye Research Institute"At the heart of this book is the curiosity and determination of one man, Alan Scott. Helveston's compelling narrative makes botulinum toxin understandable, all the while tracing the fine line that distinguishes poison from medicine. Death to Beauty is an important addition to the history of medicine."—Edward O'Malley, MD, Senior Staff Physician Emeritus, Henry Ford Health"Eugene Helveston, M.D. documents the amazing story of Botulinum toxin from a deadly problem to a very important therapeutic advance for patients with multiple types of neurological conditions, from various movement disorders' treatment to helping alleviating the misery of migraine headaches. Botulinum toxin has been a great advance for neurologists treating many needy patients."—David A. Josephson, M.D., Josephson-Wallack-Munshower Neurology, P.C."Dr. Scott would be proud and grateful."—C. William Hanke, MD, MPH, Former President, American Academy of Dermatology
£18.04
MIT Press Ltd Quantitative Fundamentals of Molecular and
Book SynopsisA comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena.This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering.The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After i
£68.40
Pearson Education (US) Medicinal Chemistry
Book SynopsisTable of Contents1 A Brief History of Drug Discovery 2 The Modern Drug Process 3 A Trip through the Body 4 Enzymes as Drug Targets 5 Receptors as Drug Targets 6 Oligonucleotides as Drug Targets 7 Pharmacokinetics 8 Metaboism 9 Molecular Structure and Diversity 10 Lead Discovery 11 Lead Optimization- Traditional Methods 12 Lead Optimization- Hansch Analysis 13 Aspects in Pharmaceutical Synthesis
£154.10
Taylor & Francis Ltd RealWorld Evidence in Drug Development and
Book SynopsisReal-world evidence (RWE) has been at the forefront of pharmaceutical innovations. It plays an important role in transforming drug development from a process aimed at meeting regulatory expectations to an operating model that leverages data from disparate sources to aid business, regulatory, and healthcare decision making. Despite its many benefits, there is no single book systematically covering the latest development in the field.Written specifically for pharmaceutical practitioners, Real-World Evidence in Drug Development and Evaluation, presents a wide range of RWE applications throughout the lifecycle of drug product development. With contributions from experienced researchers in the pharmaceutical industry, the book discusses at length RWE opportunities, challenges, and solutions.Features Provides the first book and a single source of information on RWE in drug development Covers a broad array of topics on outTable of Contents1 Using Real-world Evidence to Transform Drug Development: Opportunities and Challenges. 2. Evidence derived from real world data: utility, constraints and cautions. 3. Real-World Evidence from Population-Based Cancer Registry Data. 4. External Control using RWE and Historical Data in Clinical Development. 5. Bayesian method for assessing drug safety using real-world evidence. 6. Real-World Evidence for Coverage and Payment Decisions. 7. Causal Inference for Observational Studies/Real-World Data. 8. Introduction to Artificial Intelligence and Deep Learning with a Case Study in Analyzing Electronic Health Records for Drug Development.
£114.00
CRC Press Handbook of Microbiological Quality Control in
Book SynopsisMicrobiologists working in both the pharmaceutical and medical device industries, face considerable challenges in keeping abreast of the myriad microbiological references available to them, and the continuously evolving regulatory requirements. The Handbook of Microbiological Quality Control provides a unique distillation of such material, by providing a wealth of microbiological information not only on the practical issues facing the company microbiologist today, but also the underlying principles of microbiological quality assurance. All the chapters have been written by leading experts in this field. The Handbook of Microbiological Quality Control provides guidance on safe microbiological practices, including laboratory design and sampling techniques. The design storage, use and quality control of microbiological culture is considered in depth. Principles of enumeration and identification of micro-organisms, using both traditional and rapid methods as well as the pharmacopoeial methTable of ContentsSafety in Microbiology. Culture Media. Sampling. Enumeration of Micro-organisms. Identification of Micro-organisms. Specified Organisms. Rapid Methods. Sterility Assurance. Endotoxin Testing. Preservative Efficacy Testing. Microbiological Assay. Disinfection and Cleansing. Microbiological Audit. Case Studies and Calculations.
£58.89
CRC Press Handbook of Validation in Pharmaceutical
Book SynopsisRevised to reflect significant advances in pharmaceutical production and regulatory expectations, Handbook of Validation in Pharmaceutical Processes, Fourth Edition examines and blueprints every step of the validation process needed to remain compliant and competitive. This book blends the use of theoretical knowledge with recent technological advancements to achieve applied practical solutions. As the industry's leading source for validation of sterile pharmaceutical processes for more than 10 years, this greatly expanded work is a comprehensive analysis of all the fundamental elements of pharmaceutical and bio-pharmaceutical production processes. Handbook of Validation in Pharmaceutical Processes, Fourth Edition is essential for all global health care manufacturers and pharmaceutical industry professionals.Key Features: Provides an in-depth discussion of recent advances in sterilization Identifies obstacles tTable of Contents1. Why Validation?, 2. Facility Design for Validation, 3. Modular Facilities – Meeting the Need for Flexibility, 4. Commissioning and Qualification, 5. Design & Quaification of Controlled Environments, 6. Validation of Pharmaceutical Water Systems, 7. Validation of Critical Utilities, 8. Calibration and Metrology, 9. Risk Management and Thermal Validation, 10. Change Control, 11. MICROBIOLOGY OF STERILIZATION PROCESSES, 12. Biological Indicators, 13. Steam Sterilization in Autoclaves, 14. Validation of Terminal Sterilization, 15. Steam Sterilization-in-Place Technology and Validation, 16. Dry Heat Sterilization, 17. Depyrogenation by Inactivation and Removal, 18. Ethylene Oxide Sterilization, 19. Validation of chlorine dioxide Sterilization, 20. Liquid Phase Sterilization, 21. Vapor Sterilization and Decontamination, 22. Validation of the Radiation Sterilization of Pharmaceuticals, 23. Validation of Sterilizing Grade Filters, 24. Disinfecting Agents: The Art of Disinfection, 25. Cleaning and Disinfecting Laminar Flow Workstations, Bio Safety Cabinets and Fume Hoods, 26. Contamination Control for Component Introduction to Classified Areas, 27. Aseptic Processing for Dosage Form Manufacture, 28. Validation of Manual Aseptic Processes, 29. Validation of Aseptic Processing for Bulk Pharmaceutical Chemicals, 30. Qualification and Validation of Advanced Aseptic Processing Technologies, 31. Total Particle Monitoring, 32. Environmental Monitoring, 33. Validation of Container Component Preparation, 34. Validation of Lyophilization, 35. Validation of Packaging Processes for Sterile Products, 36. Validation of Active Pharmaceutical Ingredients, 37. Cell Culture Process Validation including Cell Bank Qualification, 38. Validation of Recovery and Purification Processes, 39. Validation of Process Chromatography, 40. Single Use Technologies and Systems, 41. Considerations for Process Validation for Cell and Gene Therapies, 42. Validation of Solid Dosage Forms, 43. Validation of Validation of Oral / Topical Liquids & Semi-Solids, 44. Validation of Non-Sterile Packaging Operations, 45. Validation of Cleaning Processes, 46. Validation of Training, 47. Vendor Qualification and Validation, 48. Validation of Clinical Trial Manufacturing, 49. Validation of New Products, 50. Retrospective / Continuous Process Validation, 51. Validation & 6 Sigma, 52. Validation and Contract Manufacturing, 53. Computerized Systems Validation, 54. Risk Based Validation of Laboratory Information Management Systems, 55. Control Systems Validation, 56. Process Analytical Technology and Validation, 57. Validation of Analytical Procedures and Physical Methods, 58. Validation of Microbial Methods, 59. "Rapid Methods for Aseptic Processing and Their Validation", 60. Extractables and Leachables in Drug Products: An Overview, 61. Evolution and Implementation of Validation in the United States, 62. Validation in Europe - What are the Differences?, 63. Japanese Approach to Validation, 64. Organization of Validation in a MultiNational Pharmaceutical Company, 65. Validation in a Small Pharmaceutical Company, 66. Regulatory Aspects of Process Validation in the United States, 67. The Future of Validation
£204.25
Taylor & Francis Ltd Wild Plants The Treasure of Natural Healers
Book SynopsisThis book offers a broad summary of the wild plants and their usage, as well as the growing interest in ethnopharmacology research. The book comprises of important issues such as diversity of wild plants with emphasis on medicinal and food plants, threats to wild plants and traditional ethnobotanical knowledge, their uses in skin diseases, snake-bites, in cosmeceuticals, etc. Moreover, the ethnopharmacological relevance of wild plants in Latin America has been discussed. The chapters include a wide range of case studies, giving updated evidence on the importance of their wild plant resources from different countries including Peru, Nepal, Bangladesh, India, Pakistan, Brazil. In addition, some specific species are used to explain their potential properties, as well as the dangers of their use without guidance of trained natural healers. The book discusses traditional usage and properties of wild plants and is entirely different from other related publications and useful for the reseaTable of ContentsGENERAL. Wild Plants as a Treasure of Natural Healers: The Need for Unlocking the Treasure. The Disappearance and Substitution of Native Medicinal Species. SPECIFIC COUNTRIES. Wild Plants of Northern Peru: Traditions, Scientific Knowledge and Innovation. Ethnic Uses of Plant Species among Magar People in Nepal. Some Plants Used as Phytomedicine by Tribal Healers of Chittagong Hill Tracts, Bangladesh. Argentinian Wild Plants as Controllers of Fruits Phytopathogenic Fungi: Trends and Perspectives. Plants from Brazil used against Snake Bites: Oleanolic and Ursolic Acids as Antiophidian against Bothrops jararacussu venom. Latin American Endemic (Wild) Medicinal Plants with High-Value: Ethnobotanical, Pharmacological, and Chemical Importance. Phytochemicals from Wild Medicinal and Aromatic Plants of Argentina. The Zig-Zag Trail of Symbiosis among Chepang, Bat, and Butter Tree: An Analysis on Conservation Threat in Nepal. SPECIFIC PLANTS AND AILMENTS. Role of Wild Plants in Curing and Healing the Skin Diseases. Choerospondias axillaris (Hog plum): Multiple Health Benefits. Artemisia Species: Medicinal Values with Potential Therapeutic Uses. The Potential Use of Mandacaru (Cereus spp.) Bioactive Compounds. Subfamily Bombacoideae: Traditional Uses, Secondary Metabolites, Biological Activities and Mechanistic Interpretation of the Anti-Inflammatory Activity. Ayahuasca: Inherent Dangers in Its Consumption. Exploring the Plant Kingdom for Sources of Skincare Cosmeceuticals: From Indigenous Knowledge to the Nanotechnology Era. Ethnomedicinal and Pharmacological Importance of Glycyrrhiza glabra L.
£175.75
Taylor & Francis Ltd RealWorld Evidence in a PatientCentric Digital
Book SynopsisReal-world evidence is defined as evidence generated from real-world data outside randomized controlled trials. As scientific discoveries and methodologies continue to advance, real-world data and their companion technologies offer powerful new tools for evidence generation. Real-World Evidence in a Patient-Centric Digital Era provides perspectives, examples, and insights on the innovative application of real-world evidence to meet patient needs and improve healthcare, with a focus on the pharmaceutical industry.This book presents an overview of key analytical issues and best practices. Special attention is paid to the development, methodologies, and other salient features of the statistical and data science techniques that are customarily used to generate real-world evidence. It provides a review of key topics and emerging trends in cutting-edge data science and health innovation.Features: Provides an overview Table of ContentsPreface: Real World Evidence and Digital Innovation to Combat Noncommunicable Diseases. 1. Real World Evidence Generation. 2. Applications of RWE for Regulatory Uses. 3. Ethics & Bioethics. 4. Real- World Data, Big Data and Artificial Intelligence: Recent Development and Emerging Trends in the European Union. 5. Patient centricity and Precision Medicine. 6. Health Information Technology. 7. Digital Health Technologies and Innovations. 8. Economic Analysis and Outcome Assessment. 9. Partnerships and Collaborations. 10. Global Perspective: China Big Data Collaboration to Improve Patient Care. 11. The Future of Patient-Centric Data-Driven Healthcare
£99.75
Taylor & Francis Ltd Drug Misuse and Community Pharmacy
Book SynopsisDrug misuse is a major challenge for health professionals in the 21st century, and community pharmacy holds a key place in the management of prescribed medication, the provision of health education and promotion messages to drug users. Two decades ago there would have been no need for a book to describe such the role of community pharmacy; however, since more people are injecting drugs now and HIV is on the rise, community pharmacists have found their services in higher demand. The quality practice of tomorrow hinges on trained and competent practitioners working in a variety of community pharmacy settings. Drug Misuse and Community Pharmacy explains the historical, research and practical aspects. Experts use a practical and evidence-based approach to educate students of pharmacy, pre-registration pharmacists, community pharmacists working with drug users and anyone involved in developing and managing primary healthcare for drug misusers.Table of ContentsPart 1: Background. Opiate Addiction and the British System: Looking Back on the Twentieth Century and Trying to see its Shape in the Future. Drug Misuse and the Community Pharmacist: a Historical Overview. Part 2: Surveying the Situation. Reviewing the Situation - Pharmacists and Drug Misuse Services in England and Wales. Drug Misuse and Community Pharmacy in Scotland. Drug Misuse in Northern Ireland: the Role of the Community Pharmacist. Drug Users and Pharmacists: the Client Perspective. Part 3: Working with Drug Users. The History and Operation of Pharmacy Needle Exchanges. New Approaches to Dispensing Controlled Drugs: Supervised Consumption. Providing Health Care for Drug Users. Misuse Over-the-Counter Products. Part 4: Practical Matters - Training, Support and Shared Care. Legal and Ethical Considerations for Community Pharmacists. Training and Support for Pharmacists. Professional Conflicts for the Front-Line Community Pharmacist. Shared Care at the Primary and Secondary Interface: The Role of GPs and Specialist Drug Services. Part 5: The Way Forward. The Way Forward - Greater Specialism or More Generalism?
£54.14
Elsevier Science Progress in Medicinal Chemistry
Book SynopsisWhat defines a quality lead, where these quality leads come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry. This volume addresses these questions and discusses diabetes, obesity and tuberculosis. It presents research in the field of drug discovery.Table of ContentsPreface List of Contributors Hit and Lead Identification: Efficient practices for drug discovery DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes Recent Progress Towards Nonpeptide Ligands for the Melanocortin-4 Receptor Tuberculosis chemotherapy: recent developments and future perspectives Subject Index Author Index (Volumes 1-45) Subject Index (Volumes 1-45)
£151.05
John Wiley & Sons Inc Comprehensive Quality by Design for
Book SynopsisThis book is a structured approach to designing a product and its associated manufacturing process. It shows pharmaceutical engineers and scientists involved in product and process development how to utilize QbD practices and applications effectively while complying with government regulations.Table of ContentsList of Contributors xiiiPreface xix1 Introduction 1Christine Seymour and Gintaras V. Reklaitis1.1 Quality by Design Overview 11.2 Pharmaceutical Industry 21.3 Quality by Design Details 31.4 Chapter Summaries 4References 72 An Overview of the Role of Mathematical Models in Implementation of Quality by Design Paradigm for Drug Development and Manufacture 9Sharmista Chatterjee, Christine M. V. Moore, and Moheb M. Nasr2.1 Introduction 92.2 Overview of Models 92.3 Role of Models in QbD 122.4 General Scientific Considerations for Model Development 202.5 Scientific Considerations for Maintenance of Models 222.6 Conclusion 23References 233 Role of Automatic Process Control in Quality by Design 25Mo Jiang, Nicholas C. S. Kee, Xing Yi Woo, Li May Goh, Joshua D. Tice, Lifang Zhou, Reginald B. H. Tan, Charles F. Zukoski, Mitsuko Fujiwara, Zoltan K. Nagy, Paul J. A. Kenis, and Richard D. Braatz3.1 Introduction 253.2 Design of Robust Control Strategies 313.3 Some Example Applications of Automatic Feedback Control 353.4 The Role of Kinetics Modeling 403.5 Ideas for a Deeper QbD Approach 423.6 Summary 44Acknowledgments 46References 474 Predictive Distributions for Constructing the ICH Q8 Design Space 55John J. Peterson, Mohammad Yahyah, Kevin Lief, and Neil Hodnett4.1 Introduction 554.2 Overlapping Means Approach 564.3 Predictive Distribution Approach 594.4 Examples 614.5 Summary and Discussion 68Acknowledgments 69References 695 Design of Novel Integrated Pharmaceutical Processes: A Model]Based Approach 71Alicia Román]Martínez, John M. Woodley, and Rafiqul Gani5.1 Introduction 715.2 Problem Description 735.3 Methodology 765.4 Application: Case Study 805.5 Conclusions 91References 916 Methods and Tools for Design Space Identification in Pharmaceutical Development 95Fani Boukouvala, Fernando J. Muzzio, and Marianthi G. Ierapetritou6.1 Introduction 956.2 Design Space: A Multidisciplinary Concept 986.3 Integration of Design Space and Control Strategy 1026.4 Case Studies 1026.5 Conclusions 119Acknowledgment 120References 1207 Using Quality by Design Principles as a Guide for Designing a Process Control Strategy 125Christopher L. Burcham, Mark LaPack, Joseph R. Martinelli, and Neil McCracken7.1 Introduction 1257.2 Chemical Sequence, Impurity Formation, and Control Strategy 1307.3 Mass Transfer and Reaction Kinetics 1407.4 Optimal Processing Conditions 1657.5 Predicted Product Quality under Varied Processing Conditions 1747.6 Conclusions 186Acknowledgments 187Notation 187Acronyms 187Symbols 187Notes 189References 1898 A Strategy for Tablet Active Film Coating Formulation Development Using a Content Uniformity Model and Quality by Design Principles 193Wei Chen, Jennifer Wang, Divyakant Desai, Shih]Ying Chang, San Kiang, and Olav Lyngberg8.1 Introduction 1938.2 Content Uniformity Model Development 1978.3 RSD Model Validation and Sensitivity Analysis for Model Parameters 2128.4 Model]Based Design Space Establishment for Tablet Active Film Coating 2198.5 Summary 229Notations 230References 2309 Quality by Design: Process Trajectory Development for a Dynamic Pharmaceutical Coprecipitation Process Based on an Integrated Real]Time Process Monitoring Strategy 235Huiquan Wu and Mansoor A. Khan9.1 Introduction 2359.2 Experimental 2379.3 Data Analysis Methods 2399.4 Results and Discussion 2409.5 Challenges and Opportunities for PCA]Based Data Analysis and Modeling in Pharmaceutical PAT and QbD Development 2509.6 Conclusions 252Acknowledgments 252References 25310 Application of Advanced Simulation Tools for Establishing Process Design Spaces Within the Quality by Design Framework 257Siegfried Adam, Daniele Suzzi, Gregor Toschkoff, and Johannes G. Khinast10.1 Introduction 25710.2 Computer Simulation]Based Process Characterization of a Pharmaceutical Blending Process 26110.3 Characterization of a Tablet Coating Process via CFD Simulations 27610.4 Overall Conclusions 294References 29511 Design Space Definition: A Case Study—Small Molecule Lyophilized Parenteral 301Linas Mockus, David LeBlond, Gintaras V. Reklaitis, Prabir K. Basu, Tim Paul, Nathan Pease, Steven L. Nail, and Mansoor A. Khan11.1 Introduction 30111.2 Case Study: Bayesian Treatment of Design Space for a Lyophilized Small Molecule Parenteral 30211.3 Results 30711.4 Conclusions 311Appendix 11.A Implementation Using WinBUGS and R 311Shelf Life 315Notation 316Acknowledgments 317References 31712 Enhanced Process Design and Control of a Multiple]Input Multiple]Output Granulation Process 319Rohit Ramachandran12.1 Introduction and Objectives 31912.2 Population Balance Model 32012.3 Simulation and Controllability Studies 32312.4 Identification of Existing “Optimal” Control]Loop Pairings 32712.5 Novel Process Design 33012.6 Conclusions 335References 33613 A Perspective on the Implementation of QbD on Manufacturing through Control System: The Fluidized Bed Dryer Control with MPC and NIR Spectroscopy Case 339Leonel Quiñones, Luis Obregón, and Carlos Velázquez13.1 Introduction 33913.2 Theory 34013.3 Materials and Methods 34413.4 Results and Discussion 34813.5 Continuous Fluidized Bed Drying 35513.6 Control Limitations 35613.7 Conclusions 357Acknowledgment 357References 35714 Knowledge Management in Support of QbD 361G. Joglekar, Gintaras V. Reklaitis, A. Giridhar, and Linas Mockus14.1 Introduction 36114.2 Knowledge Hierarchy 36314.3 Review of Existing Software 36414.4 Workflow]Based Framework 36514.5 Drug Substance Case Study 36814.6 Design Space 37414.7 Technical Challenges 38214.8 Conclusions 384References 385Index 387
£134.06
Elsevier Health Sciences Aultons Pharmaceutics
Book SynopsisTable of ContentsPreface ....................................................................... vii Contributors ............................................................. ix Acknowledgements .................................................. xiii What is 'pharmaceutics'?......................................... xv Kevin M.G. Taylor and Michael E. Aulton 1. Design of dosage forms.................................. 1 Peter York 2. Dissolution and solubility ............................. 13 Michael E. Aulton 3. Properties of solutions ................................... 30 Michael E. Aulton 4. Surfaces and interfaces ................................... 39 Graham Buckton 5. Disperse systems.............................................. 50 David Attwood 6. Rheology........................................................... 81 Christopher Marriott 7. Kinetics ............................................................. 101 Gareth R. Williams and John P. Malkinson 8. Solid-state properties .................................... 114 Graham Buckton 9. Particle size analysis ..................................... 126 Kevin M.G. Taylor 10. Particle size reduction and size separation....................................................... 143 Michael E. Aulton 11. Mixing............................................................. 156 Andrew M. Twitchell 12. Powder flow................................................... 172 Michael E. Aulton 13. Fundamentals of microbiology................... 184 Lara-Marie Barnes and Geoffrey W. Hanlon 14. Pharmaceutical applications of microbiological techniques.......................... 208 Lara-Marie Barnes and Norman A. Hodges 15. Action of physical and chemical agents on microorganisms....................................... 229 Lara-Marie Barnes, Geoffrey W. Hanlon and Norman A. Hodges 16. Principles of sterilization ............................. 247 Susannah E. Walsh, Katie Laird and Jean-Yves Maillard 17. Sterilization in practice ................................ 257 Jean-Yves Maillard, Katie Laird and Susannah E. Walsh 18. Introduction to biopharmaceutics.............. 275 Marianne Ashford and Kevin M.G. Taylor 19. Gastrointestinal tract e physiology and drug absorption............................................. 279 Marianne Ashford and Kevin M.G. Taylor 20. Bioavailability e physicochemical, dosage form and formulation factors ........ 297 Marianne Ashford, Kevin M.G. Taylor and Hala M. Fadda 21. Assessment of biopharmaceutical properties ....................................................... 320 Marianne Ashford and Kevin M.G. Taylor 22. Dosage regimens ........................................... 343 Soraya Dhillon and Nkiruka Umaru 23. Pharmaceutical preformulation .................. 360 Simon Gaisford 24. Solutions ........................................................ 386 Sudaxshina Murdan 25. Clarification ................................................... 397 Andrew M. Twitchell 26. Suspensions ................................................... 407 Susan A. Barker 27. Emulsions and creams ................................. 424 Gillian M. Eccleston 28. Ointments, pastes, gels, cutaneous patches and topical sprays........................... 453 Majella E. Lane 29. Powders, granules and granulation ............ 463 Michael E. Aulton 30. Drying............................................................. 483 Michael E. Aulton and Satyanarayana Somavarapu 31. Tablets and compaction............................... 501 Göran Alderborn and Göran Frenning 32. Modified-release oral drug delivery ............ 542 Emma L. McConnell, Christine M. Madla and Abdul W. Basit 33. Coating of tablets and multiparticulates ... 558 Stuart C. Porter 34. Continuous manufacturing of tablets ........ 574 Aktham Aburub and Hala M. Fadda 35. Hard capsules ................................................ 586 Brian E. Jones 36. Soft capsules .................................................. 599 Stephen Tindal 37. Dissolution testing of solid dosage forms............................................................... 612 Ana Cristina Freire, Francesca K.H. Gavins and Abdul W. Basit 38. Parenteral drug delivery ............................... 626 Robert Lowe 39. Pulmonary drug delivery ............................. 641 Kevin M.G. Taylor 40. Nasal drug delivery....................................... 658 Gary P. Martin and Alison B. Lansley 41. Ocular drug delivery..................................... 677 Hala Fadda, Ashkan Khalili, Peng Tee Khaw and Steve Brocchini 42. Otic drug delivery ......................................... 701 Xu Liu, Hugh Smyth and Feng Zhang 43. Topical and transdermal drug delivery ...... 713 Adrian C. Williams 44. Rectal and vaginal drug delivery................. 735 Kalliopi Dodou 45. Preparation and delivery of biopharmaceuticals....................................... 752 Ijeoma F. Uchegbu and Andreas G. Schätzlein 46. Pharmaceutical nanotechnology and nanomedicines .............................................. 768 Yvonne Perrie 47. Radiopharmaceuticals................................... 789 Neil Hartman and Margaret Cooper 48. The formulation and manufacture of plant medicines............................................. 805 G. Brian Lockwood 49. Design and administration of medicines for paediatric and geriatric patients............ 818 Catherine Tuleu, Mine Orlu and David Wright 50. Packaging ....................................................... 833 Sudaxshina Murdan 51. Chemical stability in dosage forms............ 848 Andrew R. Barnes and Mark Santillo 52. Microbial contamination, spoilage and preservation of medicines............................ 860 Norman A. Hodges and Lara-Marie Barnes 53. Product stability and stability testing......... 871 Paul Marshall 54. Pharmaceutical quality: the application of pharmaceutics in medicines regulation ....................................................... 894 Kevin M.G. Taylor, Majella E. Lane and Khalid A. Sheikh Self-assessment questions Sudaxshina Murdan Please check your eBook at https://studentconsult. inkling.com/ for self-assessment questions. See inside cover for registration details. Index.......................................................................... 915
£50.39
CRC Press Physiological Pharmaceutics
Book SynopsisIn recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material.This book provides an integrated approach to the study of drug formulation in the body with the emphasis on the formulation variables rather than the drugs. The link between physiology and pharmaceutics is presented to give an essential background of biological principles for the pharmacy student, pharmaceutical formulator and healthcare professional. Complex mathematical aspects of physical chemistry have been avoided to facilitate understanding, enabling the reader to concentrate on how the biological environment affects the performance of the drugs and dosage forms. As the majority of drugs are administered via the oral route a large proportion of the book is devoted to theTrade Review'Provides essential information...There is no equivalent source work.' '...a worthwhile and valuable contribution to this area.'Table of Contents1. Cell Membranes, Epithelial Barriers and Drug Absorption 2. Parenteral Drug Delivery 3. Drug Delivery to the Oral Cavity or Mouth 4. Oesophageal Transit 5. The Stomach 6. Drug Absorption from the Small Intestine 7. Drug Delivery to the Large Intestine and Rectum 8. Transdermal Drug Delivery 9. Nasal Drug Delivery 10. Pulmonary Drug Delivery 11. Ocular Drug Delivery 12. Vaginal and Intrauterine Drug Delivery.
£65.54
Taylor & Francis Ltd Ibuprofen A Critical Bibliographic Review Taylor
Book SynopsisIbuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.Table of Contents1. History and Development of Ibuprofen K.D. Rainsford 2. The Medicinal Chemistry of Ibuprofen K.J. Nichol 3. The Pharmaceutics of Ibuprofen F. Higton 4. The Pharmacokinetcs of Ibuprofen in Humans and Animals D.R. Brocks and F. Jamaili 5. Pharmacology and Toxicology of Ibuprofen K.D. Rainsford 6. Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases W.F. Kean, W.W. Buchanan and K.D. Rainsford 7. Safety and Efficacy of Non-Prescription (OTC) Ibuprofen K.D. Rainsford 8. Use of Ibuprofen in Dentistry R.A. Dionne and S.A. Cooper 9. Gastrointestinal Adverse Drug Reactions Attributed to Ibuprofen D.A. Henry, A. Drew and S. Beuzeville 10. Renal Effects of Ibuprofen M.D. Murray and D.C. Brater 11. Adverse Drug Reactions Attributed to Ibuprofen: Effects Other Than Gastrointestinal L.J. Miwa and J.K. Jones 12. Human Toxicity of Ibuprofen G.N. Volans and R. Fitzpatrick Nichol, Boots Pharmaceuticals, UK, F. Higton, Boots Healthcare International, D.R. Brock, Western University of Health Sciences, USA, F. Jamaili, University of Alberta, USA, W.F. Kean, McMaster University, Canada, W.W. Buchanan, Sir William Osler Health Institute, Canada, R.A. Dionne, National Istitute of Health, USA, S.A. Cooper, Whitehall-Robins Health Care, USA, D.A. Henry, Newcastle Mater Hospital, Australia, A. Drew, Newcastle Mater Hospital, Australia, S. Beuzeville, Newcastle Mater Hospital, Australia, M.D. Murray, Regenstrief Health Centre, USA, D.C. Brater, Indiana university School of Medicine, USA, L.J. Miwa, The Degge Group, USA, J.K. Jones, The Degge Group, USA, G.N. Volans, Guys and St. Thomas' Hospital Trust, UK, R. Fitzpatrick, Guys and St. Thomas' Hospital Trust, UK.
£266.00
Taylor & Francis Ltd Interindividual Variability in Human Drug
Book SynopsisThe book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academiTable of ContentsGenetic Factors That Cause Variability in Human Drug Metabolism. Interethnic Differences in Drug Disposition and Effects. Developing and Ageing as Sources of Variability in Drug Metabolism. Genetic and Environmental Factors Causing Variability in Psychotropic Drug Response. Interindividual Variability in the Metabolism of Cardiovascular Drugs. Interindividual Variability in the Metabolism of Antiepileptic Drugs and its Clinical Implications. Variability in the Metabolism of Levodopa and its Clinical Implications. Interindividual Variability in the Disposition of Anti-HIV Drugs. Predictive Modeling of in vivo Drug Interaction From in vitro Data: From Theory to a Computer-based Workbench and Experimental Validation. Interindividual Variation of P450 Enzymes in vitro and it's Causes. Interindividual Variability of Arylamine N-acetyltransferases. Interindividual Variation of UDP-glucuronosyl Transferases and Drug Glucuronidation. Interindividual Variability of Methyltransferases. Interindividual Variability of Sulpho Transferases. Interindividual Variability of Glutathione Transferase Expression
£237.50
Taylor & Francis Ltd Aspirin and Related Drugs
Book SynopsisReviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.With extensive data and literTable of ContentsHistory and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence, Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen). Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions.
£209.00
Taylor & Francis Inc Virtual Screening in Drug Discovery 1 Drug
Book SynopsisVirtual screening can reduce costs and increase hit rates for lead discovery by eliminating the need for robotics, reagent acquisition or production, and compound storage facilities. The increased robustness of computational algorithms and scoring functions, the availability of affordable computational power, and the potential for timely structural determination of target molecules, have provided new opportunities for virtual screening, and made it more practical. Why then, isn't everyone using virtual screening? Examining the scope and limitations of this method, Virtual Screening in Drug Discovery explores the algorithms involved and how to actually use them. Part I offers perspectives on both ligand-based and docking-based virtual screens. The authors of these chapters frame many of the challenges currently facing the field. Part II considers the choice of compounds that are best suited as drug leads. Part III discusses ligand-based approaches, incluTable of ContentsPerspectives on Virtual Screening. Compound and Hit Suitability for Virtual Screening. Ligand-Based Virtual Screening Approaches. Important Considerations Impacting Molecular Docking. Docking Strategies and Algorithms.
£199.50
CRC Press Encyclopedia of Medical Genomics and Proteomics
Book SynopsisUpdating researchers on phenomenal progress in the field of molecular medicine the Encyclopedia of Medical Genomics and Proteomics offers trail-blazing studies and authoritative contributions from more than 400 specialists. An important and timely contribution to the biomedical community, the encyclopedia compiles recommendations and research and features coverage of key methods and technologies related to a range of areas. Topics include:Molecular diagnosticsGenomics, microbiology, genetics, and pharmacogeneticsManagement of infectious, neoplastic, and genetic diseasesTreatment of chronic, hereditary, and congenital disordersMedical applications of nucleic acid and protein technologyCell typingDisease susceptibility Predictive genetic and pharmacogenetic testing and tissue typing for transplantationDNA sequencing, point-of-care testing, and quality managementOncology and cancer screeningPathology and forensic issuesDiagnostic microbiology and molecular pathologyEthical issues related to genetics Also Available OnlineThis Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including:Citation tracking and alertsActive reference linkingSaved searches and marked listsHTML and PDF format optionsContact Taylor and Francis for more information or to inquire about subscription options and print/online combination packages.US: (Tel) 1.888.318.2367; (E-mail) e-reference@taylorandfrancis.comInternational: (Tel) +44 (0) 20 7017 6062; (E-mail) online.sales@tandf.co.uk
£593.75
Taylor & Francis Inc Thermal Analysis of Pharmaceuticals
Book SynopsisAs a result of the Process Analytical Technologies (PAT) initiative launched by the U.S. Food and Drug Administration (FDA), analytical development is receiving more attention within the pharmaceutical industry. Illustrating the importance of analytical methodologies, Thermal Analysis of Pharmaceuticals presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data.The book opens with the first three chapters devoted to differential scanning calorimetry (DSC), the most commonly used thermal method. These chapters cover the principles, optimal use, and pharmaceutical applications of the method. Subsequent chapters explore modulated temperature DSC, thermogravimetric analysis, thermal microscopy, microcalorimetry, high sensitivity DSC, dynamic mechanical analysis, and thermally stimulated current, all of which hTrade Review“… presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data. … achieves and ideal balance in the depth, relevance, and accessibility of topic presented. The book provides an excellent overview of this key area in pharmaceutical development.” — In Anticancer Research, Vol. 27, No. 3B, May/June 2007"The editors did a really good job in creating a fine balance between topics of commonly used, well-established methods, and of techniques that are the focus of recent research efforts . . . Due to the high scientific value, timely industrial relevance, and didactic approach, this book is an invaluable information resource for readers both in academia and industry, be they beginners or experts. I warmly recommend this book to everybody involved in solid-state analysis of pharmaceuticals, because it is the must have that I have long been waiting for." – Dr. Ádám Demeter, Gedeon Richter Plc, in ChemMedChem, 2008, No. 3Table of ContentsPrinciples of Differential Scanning Calorimetry. Optimizing DSC Experiments. Pharmaceutical Applications of DSC. Modulated Temperature Differential Scanning Calorimetry. Thermogravimetric Analysis: Basic Principles. Thermogravimetric Analysis: Pharmaceutical Applications. Thermal Microscopy. Principles and Pharmaceutical Applications of Isothermal Microcalorimetry. High Sensitivity Differential Scanning Calorimetry. Thermorheological (Dynamic Oscillatory) Characterisation of Pharmaceutical and Biomedical Polymers. The Use of Thermally Stimulated Current Spectroscopy within the Pharmaceutical Sciences.
£199.50
Taylor & Francis Inc Sterile Product Facility Design and Project
Book SynopsisKnowing how to deal with the regulatory issues, understanding the impacts of cleanliness, and recognizing the affect that poor facility layout will have on GMP spaces are only some of the issues an experienced Project Manager must focus on. Completely revised and updated, Sterile Product Facility Design and Project Management, Second Edition provides comprehensive guidance on how to develop and execute biotech and other sterile drug facilities based on current industry best practices. Each chapter highlights a specific issue centered on managing biotech facilities projects in a GMP environment. The author uses real-world examples of common industry practice to lead you through the idiosyncrasies of a biotech project in an effort to answer some of the more common, and often perplexing, questions that can stand in the way of success. You get a mini seminar on each topic covered.Breaking the project life-cycle into four phases, the text takes you through each phase from thTable of ContentsIntroduction to Facility Project Management Project Formation Defining the Project Team Facility Programming Project Control Current Good Manufacturing Practice (cGMP): Project Impacts Mechanical Systems GMP Compliance in Architectural Design and Construction Commissioning Quality Management to Meet Regulatory Requirements Establishment Licensing Containment Basics Multi-product Facilities for Biologics Contract Formulation and Philosophy Future Trends
£285.00
Taylor & Francis Inc Fluid Sterilization by Filtration
Book SynopsisCompletely revised and updated, Fluid Sterilization by Filtration, Third Edition discusses the use of gas and fluid filtration systems in sterilization technology. Packed with information useful to both the novice and the expert, it includes line-drawing illustrations, filtration setups, and plots of math functions illustrating fluid flows through filter media built from a random packing of solids. The book provides in-depth discussions of general filtration, specific membranes used in filtration, integrity testing, earlier filtration steps, and cross-flow filtration. It also includes a useful, updated appendix of worldwide contacts and many sources for equipment, supplies, and information.Table of ContentsCompletely revised and updated, Fluid Sterilization by Filtration, Third Edition discusses the use of gas and fluid filtration systems in sterilization technology. Packed with information useful to both the novice and the expert, it includes line-drawing illustrations, filtration setups, and plots of math functions illustrating fluid flows through filter media built from a random packing of solids. The book provides in-depth discussions of general filtration, specific membranes used in filtration, integrity testing, earlier filtration steps, and cross-flow filtration. It also includes a useful, updated appendix of worldwide contacts and many sources for equipment, supplies, and information.
£142.50
Taylor & Francis Inc Pharmaceutical Product Development Vol165 In
Book SynopsisDuring the last two decades, the pharmaceutical industry has been under pressure to reduce development costs and the time needed to bring drugs to market in order to maximize return on investment and bring treatments to patients sooner. To meet these ends, pharmaceutical scientists working in the differing areas of pharmacy, pharmaceutics, and pharmacokinetics are collaborating to address physicochemical and biological issues in the early stages of development to avoid problems in later stages. In Vitro-In Vivo Correlation (IVIVC) is a multidisciplinary tool that has been successfully applied in testing the effectiveness of a drug substance. The only comprehensive guide available on IVIVC, this source illustrates the emerging importance of IVIVC in the drug development process, and covers the most recent advances and regulatory perspectives on the role of IVIVC in the pharmaceutical industry.Table of ContentsIntroduction. Dissolution: Fundamentals of In Vitro Drug Release and Biopharmaceutics Classification System (BCS). Pharmacokinetics: Basics of Drug Absorption from a Biopharmaceutical Perspective. IVIVC Models: Development and Validation. Computational Approaches to Develop IVIVC Models. IVIVC - Pharmaceutical Drug/Product Development. Role of IVIVC in the Early Phases of Drug Discovery and Drug Delivery Technology Development. IVIVC - Setting Dissolution Specifications. IVIVC - Oral Drug Delivery: Immediate Release and Extended Release Dosage Forms. In Vitro-In Vivo Correlation for Modified Release Parenteral Drug Delivery Systems. IVIVC - Transdermal and Other Novel/Special Drug Delivery Systems. Regulatory Perspective. Regulatory Guidance on IVIVC: Across the World
£166.25
Taylor & Francis Inc Bioadhesive Drug Delivery Systems
Book SynopsisThis comprehensively written text covers, in-depth, all aspects of bioadhesive systems. Bioadhesive systems are presently playing a major role in the field because of their ability to maintain a dosage form at a precise body-site for a prolonged period of time over which the active principle is progressively released. Included in this book are descriptions of the different mucosae in healthy and pathological situations, a theoretical approach of polymers-mucin interactions, and a comparative description of the methods used to evaluate bioadhesion. Up-to-date reviews of pharmaceutical applications are also given - subdivided according to the route of administration and type of system. It also contains a chapter devoted to the fundamentals of bioadhesion. This reference is an indispensable guide for researchers in the pharmaceutical field as well as academic researchers.Table of ContentsMucus Physiology and Pathology. Scaling Concepts and Molecular Theories of Adhesion of Synthetic Polymers to Glycoproteinic Networks. Test Methods of Bioadhesion. Bioadhesives/Mucoadhesives in Drug Delivery to the Gastrointestinal Tract. Nanoparticles as a Gastroadhesive Drug Delivery System. Mucoadhesive Buccal Patches for Peptide Delivery. Bioadhesive Dosage Forms for Buccal/Gingival Administration. Semisolid Dosage Forms as Buccal Bioadhesives. Bioadhesive Dosage Forms for Nasal Administration. Ocular Bioadhesive Delivery Systems. Nanoparticles as Bioadhesive Ocular Drug Delivery Systems. Bioadhesive Dosage Forms for Vaginal and Intrauterine Applications.
£475.00
Taylor & Francis Inc Degradation of Bioactive Substances
Book SynopsisIntended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation. Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of specific proteins, peptides, amines, steroids, and polysaccharoides are featured. Pathophysiology and its role in diagnostics and disease are considered throughout the book, in addition to updates of recent literature and substantial new information on physiology and pathophysiology of degradation of bioactive material. No special mathematical or kinetic background is necessary to read this book because the mathematic and kinetic concepts are facilitated through the presentation of fundamental and more advanced principles. Furthermore, illustrations and tables are provided to facilitate the understanTable of ContentsINTRODUCTION. KINETICS OF WHOLE-BODY AND ORGAN DEGRADATION. Introduction. Compartmental and Multicompartmental Models. Non-Compartmental Models. Whole-Body Degradation. Organ and Tissue Degradation. Conclusion. KINETICS OF ELIMINATION FROM THE BLOOD: PRINCIPLES AND PROCEDURES. Introduction. Kinetic Models in General. Regimes of Elimination. The Concept of Clearance. Special Clearance Regimes. Experimental Procedures. Methodology. Conclusion. PEPTIDASES INVOLVED IN THE METABOLISM OF BIOACTIVE PEPTIDES. Introduction. Properties of the Peptidases. How Do Peptidases Act in Concert? Organ, Tissue and Cellular Locations of Cell Surface Peptidases. Membrane Peptidases as Cluster Differentiation (CD) Antigens. Membrane Anchorage, Release and Plasma Activity of Peptidases. Physiological Roles of Membrane Peptidases. Conclusion. RECEPTOR-MEDIATED ENDOCYTOSIS AND DEGRADATION OF POLYPEPTIDE HORMONES, GROWTH FACTORS AND NEUROPEPTIDES. Perspectives. Receptors for Polypeptide Hormones, Growth Factors and Neuropeptides. Receptor-Mediated Endocytosis. Endocytosis and Degradation of Hormones, Growth Factors, Neuropeptides and Plasma Protein. DEGRADATION OF CIRCULATING RENIN AND ANGIOTENSIN. Introduction. Physiology of Renin and Angiotensin II. Metabolism of Circulating Renin. Metabolism of Circulating Angiotensin II. The Renin-Angiotensin System in Disease. Conclusion. PROCESSING AND CLEARANCE OF ATRIAL NATRIURETIC FACTORS (ANF). Introduction. Processing of ANF Prohormone. Clearance of Bioactive ANF. Conclusion. DEGRADATION OF GASTRIC PEPTIDES: METABOLISM OF THE GASTRINS. Introduction. Structure and Synthesis of the Gastrins. Degradation of the Gastrins. Conclusion. DEGRADATION OF CIRCULATING INTESTINAL PEPTIDES: METABOLISM OF SUBSTANCE P AND VASOACTIVE INTESTINAL POLYPEPTIDE. Introduction. Degradation of Substance P. Degradation of VIP. Conclusion. DEGRADATION OF GLUCAGONS. Introduction. Structure and Synthesis of Glucagon and Related Peptides. Degradation of Glucagon. Degradation o
£498.75
Taylor & Francis Inc Generic Drug Product Development
Book SynopsisThe assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, Generic Drug Development, discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the physicaTable of ContentsIntroduction - Bioequivalence Issues. Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book). Pharmaceutical Alternatives: Considerations for Generic Substitution. Pharmacodynamic Measurements for Determination of Bioequivalence. Bioequivalence Using Clinical Endpoint Studies. Evaluation of Bioequivalence of Highly-Variable Drug Products. Statistical Considerations: Alternate Designs And Approaches For Bioequivalence Assessments. Population Pharmacokinetic Approaches for Assessing Bioequivalence. Role of Metabolites in Bioequivalence Assessment. Implications of Chirality for the Assessment of Bioequivalence. Effect of Food on Bioavailability and the Assessment of Bioequivalence. Bioequivalence Assessment of Endogenous Drug Substances : Pharmacokinetics and Statistical Evaluation.
£161.50
CRC Press A Practical Guide to Quality Management in
Book SynopsisSetting up a GXP environment where none existed previously is a very daunting task. Getting staff to write down what they do for every task is a correspondingly difficult and time-consuming exercise. Examining how to maintain quality control in clinical trial research, A Practical Guide to Quality Management in Clinical Trial Research provides a cornerstone of knowledge for establishing a quality system that complies with the relevant regulations. There are many books available that cover how to interpret regulations. Going a step or two further, this book provides practical advice that is useful on a daily basis.The book contains information for various standards including GLPs, GCPs, and GMPs. It gives detailed explanations of how to prepare, update, and maintain SOPs and includes advice on training and development of personnel. Drawing directly on his years of experience, the author delineates a from-the-trenches methodology that creates a value-added quality management system from a business perspective. He provides a solid foundation as well as tips and techniques for establishing a quality system that will comply with all the relevant regulations. The author's integrated approach and anecdotal style turns technically accurate information into easy reading. The book arms you with tools and concepts that you can use to go beyond regulatory compliance and move into the realm of business quality improvement.Trade Review"…provides the reader with a pragmatic approach to the principles governing accepted methodologies within the working environment and provides some useful examples of these interpretational differences across industry."-Quasar"…provides a solid foundation as well as tips and techniques for establishing a quality system that will comply with all the relevant regulations."--Anticancer ResearchTable of ContentsIn the Beginning There Was GLP. Before GCP. Training in the Regulated Environment. Computing in the Regulated Environment. QA Activity. Beyond Compliance. Business Improvement. A Summary. Appendix: Information Resources and Acronyms.
£166.25
Pharmaceutical Press Pharmaceutical Isolators
Book SynopsisPharmaceutical Isolators is an indispensable guide to the design, construction, commissioning, maintenance, use and monitoring of pharmaceutical isolators.Trade Review'The text is written in a clear and concise manner and desired information is readily accessible.' Linda Felton, University of Mexico, College of Pharmacy, Mexico, Drug Development and Industrial Pharmacy, 1 March 2005 -- Linda A. Felton * Drug Development and Industrial Pharmacy *Table of Contents1. Isolator Applications: 2. Design: 3. Transfer Devices: 4. Access Devices: 5. Siting of Isolators and Clothing Regimes: 6. Cleaning, Decontamination & Disinfection: 7. Physical Monitoring: 8. Leak Testing: 9. Microbiological Monitoring: 10. Validation: 11. Standards and Guidelines: 12. Definiton of Terms: A1. HSE/MCA Guidance: A2. Training: A3. Stainless Steel for Isolators: A4. HEPA Filtration Mechanisms, MPPS and Typical Particle Sizes: A5. Calculations to Estimate the Size of a Leak That Can Be Detected Using DOP: A6. Activated Carbon Filters:
£25.65
Pharmaceutical Press An Introduction to Clinical Pharmaceutics
Book SynopsisConsiders the importance of pharmaceutics and pharmaceutical dosage form design by considering the clinical use of modern drugs. This book also considers the use and behaviour of dosage forms in different age groups and patient groups along with developments such as personalised therapies and genomics.Table of Contents1. Introduction; 2. Drugs and Excipients; 3. Oral Formulations; 4. Parenteral Formulations; 5. Adverse Reactions; 6. Pharmaceutics and the Neonate; 7. Pharmaceutics of Disease States; 8. Advanced Delivery Systems.
£25.65
Pharmaceutical Press Handbook of Extemporaneous Preparation
Book SynopsisA comprehensive and easy-to-follow guide to good practice in extemporaneous compounding.Trade Review"...this resource offers a real advantage to both the prescriber and the pharmacist in the provision of quality oral liquids...Of particular use and unique to this text is the inclusion of a 'risk assessment' section in each monograph which addresses the clinical and technical risks associated with the extemporaneous preparation of each oral liquid...This book is not only a useful resource, but a valuable addition to the texts available on extemporaneous dispensing for those prescribers wanting quick access to suitable oral liquid alternatives..." Alison Haywood, Senior Lecturer, Griffith University, and Beverley Glass, Professor of Pharmacy, James Cook University Queensland, Australian Prescriber 34(5), October 2011. -- Alison Haywood * Australian Prescriber *Table of ContentsPart A - Standards 1. Glossary 2. Introduction 3. Risk Management 4. Quality Management 5. Personnel & Training 6. Premises & Equipment 7. Documentation 8. Preparation 9. Formulation & Stability 10. Quality Control 11. Complaints, Product Recalls & Adverse Events 12. Procurement & Quality Assessment 13. Audit & Monitoring Part B Extemporaneous Preparation Formulary 14. Introduction 15. Data Collection 16. Risk Assessment 17. Formulary of Extemporaneous Preparation
£43.20
Pharmaceutical Press Pharmaceutical Compounding and Dispensing
Book SynopsisThis is a modern, detailed and practical guide to the theory and practice of extemporaneous compounding and dispensing. Fully revised and updated, this new edition will be an indispensable reference for pharmacy students and practicing pharmacists.Trade Review"The book is well received, since there are few textbooks or reference books available devoted specifically to compounding. The authors should be commended for emphasizing the historical content in tandem with the preparation instruction...the book remains a good resource for anyone interested in compounding" Christine R. Birnie, PhD, American Journal of Pharmaceutical Education 75(1), Feb 2011 -- Christine R. Birnie * American Journal of Pharmaceutical Education *
£38.70
Pharmaceutical Press Essentials of Pharmaceutical Chemistry
Book SynopsisEssentials of Pharmaceutical Chemistry is an introduction to pharmaceutical chemistry for undergraduate pharmacy, chemistry and medicinal chemistry students. It covers all of the core material necessary to provide an understanding of the basic chemistry of drug molecules.Trade Review "...Donald Cairns is a well-known educator, mentor, and researcher...this is an excellent resource for pharmacy students taking pharmaceutical chemistry and for individuals who intend to pursue a career in the pharmaceutical industry...Readers will find this as a useful reference." Rahmat M Talukder, Ph.D.,Doody's Notes, May 2012. -- Rahmat M Talukder * Doody's Notes *"This is a great book detailing the basic chemistry of drugs...Throughout the book there are problems that can be worked, and it includes the answers at the end of the book. It is very easy-to-read and has very good graphics to support the discussions. In addition to being a good text, it is a good refresher for those that would like to review this topic."Compounding Today, 27 Jan 2012. * Compounding Today *Table of Contents1. Chemistry of Acids and Bases; 2. Partition Coefficient and Biopharmacy; 3. Physicochemical Properties of Drugs; 4. Stereochemistry; 5. Drug Metabolism; 6. Volumetric Analysis of Drugs; 7. Analytical Spectroscopy; 8. Chromatographic Methods of Analysis; 9. Stability of Drugs and Medicines; 10. Kinetics of Drug Stability; 11. Licensing of Drugs and the British Pharmacopoeia; 12. Medicinal Chemistry - the Science of Rational Drug Design; 13. Answers to Problems
£38.70
Telford Press Acute Toxicology Testing
Book SynopsisAcute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. For each test, applicable U.S. and international guidelines are also presented, and the formulation and selection of vehicles, dosages, and test animals are addressed.
£175.75
CRC Press Ethnobotany
Book SynopsisIn this book we present recent studies that have been carried out on some widely used medicinal plants. The need for new and alternative treatments stem from the lack of efficiency of existing remedies for certain illnesses. We have compiled information that may be useful to researchers in their quest to develop new drugs.Table of ContentsPart 1: Ethnobotany 1. The Genus Aloysia Paláu (Verbenaceae) in Argentina. A Paradigm in Ethnobotany 2. Ethnobotany of Medicinal and Sacred Plants with Ethnopharmacological Potential from Southwestern Colombia 3. Ethnobotanical Uses and Potential Pharmaceutical Applications of the Cactaceae Family 4. Traditional Use of Plants in Mexico for the Treatment of Diabetes: An Ethnopharmacological Review and Scientific Evaluations 5. Limits and Risks of Plants Valorization in Morocco Associated with Their Vernacular Names 6. Resilience of Mapuche Health System and the Influence of COVID-19 Part 2: Traditional Knowledge of Useful Plants 7. Medicinal Use of the Plants of the Atacama Desert 8. Local Botanical Knowledge of Plants Associated with Andean and Chinese Traditions in the Metropolitan Area of Buenos Aires (Argentina): An Urban Ethnobotany Study 9. Traditional Uses, Phytochemistry, and Pharmacology of Mopane (Colophospermum mopane) in Southern African Countries 10. Traditional Medicine of the Kichwa of the Upper Napo 11. Traditional Practices Regarding the Use of Botanicals to Treat Bovine Haemonchosis in Pakistan
£128.25
Taylor & Francis Ltd Synopsis of Key Gynecologic Oncology Trials
Book SynopsisThis revised and updated new edition of a best-selling text remains a fast and convenient overview of the clinical trials in gynecologic cancer treatment, outlining the evidence base of treatment decisions in uterine, ovarian, cervical, and vulvar cancers, and gestational trophoblastic neoplasia. Residents and fellows will find this book an indispensable reference, while practitioners will welcome it as a clarification of the evidence base for treatment options. *Gives a convenient summary of trials in gynecologic oncology *Supplies an invaluable revision primer for those undertaking certification *Provides a uniquely up-to-date resourceTable of ContentsPreface to the second edition1. Uterine Malignancies. 1.1. Endometrial Carcinoma. 1.1.1. Studies addressing surgical treatment. 1.1.1.1. Lymph node assessment 1.1.2. Studies addressing adjuvant therapy. 1.1.2.1. Radiation. 1.1.2.2. Chemoradiation. 1.1.2.3. Chemotherapy. 1.1.3. Studies addressing treatment of recurrent endometrial carcinoma. 1.1.3.1. Hormonal therapy. 1.1.3.2. Chemotherapy. 1.1.3.3. Targeted therapy. 1.1.3.4. Immunotherapy. 1.2. Uterine Carcinosarcoma. 1.2.1. Studies addressing prognosticators. 1.2.2. Studies addressing adjuvant treatment. 1.2.3. Studies addressing treatment of advanced/ recurrent uterine carcinosarcoma. 1.3. Uterine Leiomyosarcoma. 1.3.1. Studies addressing adjuvant treatment of early stage uterine leiomyosarcoma. 1.3.2. Studies addressing treatment of advanced uterine leiomyosarcoma. 1.4. References.2. Ovarian Malignancies. 2.1. Epithelial ovarian cancer (EOC). 2.1.1. Studies addressing upfront surgery. 2.1.2. Studies addressing adjuvant therapy. 2.1.3. Studies addressing intraperitoneal chemotherapy. 2.1.4. Studies addressing first line maintenance treatment. 2.1.5. Studies addressing neoadjuvant therapy. 2.1.6. Studies addressing prediction of debulking. 2.1.7. Studies addressing time point of treatment of recurrence. 2.1.8. Studies addressing treatment of recurrent ovarian cancer, platinum-sensitive. 2.1.8.1. Chemotherapy and targeted therapy. 2.1.8.2. Secondary debulking surgery. 2.1.9. Studies addressing treatment of recurrent ovarian cancer, platinum-resistant. 2.1.9.1. Chemotherapy and targeted therapy. 2.1.9.2. Immunotherapy. 2.2. Low grade serous ovarian cancer. 2.3. Mucinous epithelial ovarian cancer (mEOC). 2.4. Ovarian Germ Cell Tumors (GCT). 2.5. Ovarian Sex Cord-Stromal Tumors (SCT). 2.6. References.3. Cervical Cancer. 3.1. Studies addressing surgical treatment. 3.2. Studies addressing adjuvant therapy. 3.3. Studies addressing primary chemoradiation therapy. 3.4. Studies addressing treatment of recurrent or metastatic cervical cancer. 3.4.1. Chemotherapy and targeted therapy. 3.4.2. Immunotherapy. 3.5. References.4. Vulvar Cancer. 4.1. Studies addressing surgical treatment. 4.1.1. Groin lymph nodes. 4.2. Studies addressing advanced vulvar cancer. 4.2.1. Chemoradiation. 4.2.2. Immunotherapy. 4.3. References.5. Gestational Trophoblastic Neoplasia (GTN). 5.1. Studies addressing surgical treatment. 5.2. Studies addressing chemotherapy in low-risk GTN. 5.3. Studies addressing (chemo)therapy in high-risk GTN. 5.4. References.6. Glossary. Index.
£42.74
Taylor & Francis Ltd Aquatic Medicinal Plants
Book SynopsisThe use of medicinal plants in herbal and modern medicine has gained popularity over the last few decades due to consumers taking more natural approaches to medicine. Aquatic medicinal plants are rich in bioactive compounds and demonstrate various commercial, nutraceutical, and biological applications. Aquatic Medicinal Plants offers the reader a wealth of information on uses of bioactive components of these plants, along with crucial references, and explains their traditional uses, phytochemistry, and pharmacological properties.Features Provides information on aquatic and semiaquatic medicinal plants and their uses globally. Discusses phytochemical components with the known active constituents and their pharmaceutical applications. This volume in the Exploring Medicinal Plants series is appropriate for scientists, experts, and consultants associated with the exploration of aquatic medicinal plant usage. This book is an essenTable of ContentsMedicinal Importance of Nelumbo nucifera. Traditional Uses, Important Phytochemical, and Therapeutic Profile of Persicaria hydropiper. Ethnobotanical, Phytochemistry, and Pharmacological Activity of Marsilea minuta. Traditional Uses, Phytochemistry, and Pharmacological Properties of Hedychium coronarium. Pharmacognostical Phytochemical, and Ethnomedicinal Properties of Enhydra fluctuans. Medicinal Uses and Pharmacological Properties of Acorus calamus. Medicinal properties of Rotula aquatic. Traditional Uses and Pharmacological Profile of Sphaeranthus indicus. Phytochemistry and Medicinal Uses of Pistia stratiotes. Biological Activity and Medicinal Uses of Arundo donax. Sagittaria sagittifolia. Phytochemistry and Pharmaceutical Application of Laurencia obtuse: A Red Seaweed. Phytochemical and Therapeutic Properties of Didemnum genus. Brown Algae (Phaeophyta) Source of Different Phytochemical and their Medicinal Application. Phytochemistry and Bioactivity of Green Algae (Chlorophyta). Chemical Composition and Biological Activity of Red Algae (Rhodophyta).
£41.79
CRC Press Bayesian Methods in Pharmaceutical Research
Book SynopsisSince the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients.This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. TheTrade Review"The book is full of interesting real examples across the chapters, which not only makes the reading fun but also demonstrates the practical usefulness of Bayesian methods in pharmaceutical research. In synthesis, this is a very well written book, which can be used as self-learning material or as a main reference for experts and practitioners."- Pablo Emilio Verde, International Society for Clinical Biostatistics, 72, 2021Table of ContentsI Introductory part Chapter 1: Bayesian Background Chapter 2: FDA Regulatory Acceptance of Bayesian StatisticsChapter 3: Bayesian Tail Probabilities for Decision Making II Clinical development Chapter 4: Clinical Development in the Light of Bayesian Statistics Chapter 5: Prior ElicitationChapter 6: Use of Historical Data Chapter 7: Dose Ranging Studies and Dose Determination Chapter 8: Bayesian Adaptive Designs in Drug Development Chapter 9: Bayesian Methods for Longitudinal Data with MissingnessChapter 10: Survival Analysis and Censored Data Chapter 11: Benefit of Bayesian Clustering of Longitudinal Data: Study of Cognitive Decline for Precision Medicine Chapter 12: Bayesian Frameworks for Rare Disease Clinical Development Programs Chapter 13: Bayesian Hierarchical Models for Data Extrapolation and Analysis in Pediatric Disease Clinical Trials III Post-marketing Chapter 14: Bayesian Methods for Meta-AnalysisChapter 15: Economic Evaluation and Cost-Effectiveness of Health Care InterventionsChapter 16: Bayesian Modeling for Economic Evaluation Using "Real World Evidence"Chapter 17: Bayesian Benefit-Risk Evaluation in Pharmaceutical Research IV Product development and manufacturing Chapter 18: Product Development and Manufacturing Chapter 19: Process Development and Validation Chapter 20: Analytical Method and Assay Chapter 21: Bayesian Methods for the Design and Analysis of Stability Studies Chapter 22: Content Uniformity Testing Chapter 23: Bayesian methods for in vitro dissolution drug testing and similarity comparisons Chapter 24: Bayesian Statistics for Manufacturing V Additional topics Chapter 25: Bayesian Statistical Methodology in the Medical Device Industry Chapter 26: Program and Portfolio Decision-Making
£43.69
Taylor & Francis Ltd Ethnobotany and Ethnopharmacology of Medicinal
Book SynopsisMedicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants.This book: Includes computational approaches to study the pharmacological properties of biomolecules in medicinal and aromatic plants. Details methods in ethnopharmacology including chromatographical and analytical techniques. Demonstrates trends in sustainable use and management of medicinal and aromatic plants. Features information on databases and tools used in computational phytochemistry for drug designing and discovery. Elucidates the importance of phytocTable of ContentsChapter 1: Introduction to Medicinal and Aromatic Plants: Diversity, Biogeographic Distribution and Conservation Status. Chapter 2: Botanical Bases of Medicinal and Aromatic Plants. Chapter 3: Trends in Sustainable Use and Management of Medicinal and Aromatic Plants: Utilization and Development. Chapter 4: Threatened and Endangered Medicinal and Aromatic Plants. Chapter 5: Ethnobotany, Ethnopharmacology, and Traditional Uses of Medicinal and Aromatic Plants. Chapter 6: Wild Edible Medicinal and Aromatic Plants in Ancient Traditions. Chapter 7: Ethnopharmacology and Ethnopharmacognosy: Current Perspectives and Future Prospects. Chapter 8: Phytochemistry and Biosynthesis of Phytochemicals. Chapter 9: Phytochemicals as Immunomodulators, Nutraceuticals, and Pharma Food. Chapter 10: Phytochemotaxonomy: Role of Phytochemicals in Plant Classification: Chapter 11: Biological Roles and Mechanism of Phytochemicals in Disease Prevention and Treatment. Chapter 12: Metabolomics of Medicinal and Aromatic Plants. Chapter 13: Methods in Ethnopharmacology: Phytochemical Extraction, Isolation, and Detection Techniques. Chapter 14: Chromatographic Techniques in Phytochemistry and Analytical Techniques in Elemental Profiling. Chapter 15: NMR-based Metabolomics and Hyphenated NMR Techniques. Chapter 16 Animal Models in Phytopharmacology and Toxicological Testing of Plant Products. Chapter 17: Computational Phytochemistry in Drug Discovery: Databases and Tools. Chapter 18: Nanoformulations and Herbal Drug Development. Chapter 19: Novel Phytochemicals Targeting the Signaling Pathways of Anticancer Stem Cell: A Novel Approach Against Cancer. Chapter 20: Evolving Challenges and Opportunities in Plant-based Drug Discovery and Development. Index.
£37.99
CRC Press Herbal Treatment of Anxiety
Book SynopsisHerbal Treatment of Anxiety: Clinical Studies in Western, Chinese and Ayurvedic Traditions explains the nature and types of anxiety, its neurobiology, the pathophysiology that exacerbates and perpetuates it, and the psychopharmacology of the chemical agents that relieve its manifestations. Throughout the text are discussions of Western, Chinese and Ayurvedic herbal treatments that have been clinically shown to be effective in relieving anxiety. The book also features a scientific discussion of the use of herbs and essential oils in aromatherapy and the mechanisms by which they may work. The book concludes by providing bases upon which herbs can be chosen to treat the anxiety of patients according to their individual needs.Additional features include: Examines the increasingly popular subject of the use of herbs as a natural alternative treatment and provides a much-needed scientific basis for treatments often considered as merely folk medicine. Discusses the psychoactive phytochemicals contained in herbs. Includes a chapter discussing the nature and mechanisms of action of adaptogens. Adds to the armamentarium of anxiolytics for providers who have become reluctant to prescribe benzodiazepines as treatment of anxiety, particularly in the context of the opiate crisis. Gives an introduction to herbal treatments of traditional Chinese and Ayurvedic medicine. Offers practical advice on initiating and managing herbal treatments. Herbal Treatment of Anxiety is a valuable reference for psychiatrists, psychiatric nurse practitioners, primary care providers, naturopathic doctors and therapists interested in the most current scientific information on the effects of herbal treatments of anxiety disorders.
£43.69
CRC Press The Combination Products Handbook
Book SynopsisCombination products are therapeutic and diagnostic products that combine drugs, devices, and/or biological products. According to the US Food and Drug Administration (FDA), âœa combination product is one composed of any combination of a drug and a device; a biological product and a device; a drug and a biological product; or a drug, device and a biological product.â Examples include prefilled syringes, pen injectors, autoinjectors, inhalers, transdermal delivery systems, drug-eluting stents, and kits containing drug administration devices co-packaged with drugs and/or biological products. This handbook provides the most up-to-date information on the development of combination products, from the technology involved to successful delivery to market. The authors present important and up-to-the-minute pre- and post-market reviews of international combination product regulations, guidance, considerations, and best practices.This handbook: Brings clarity of understanding for global combination products guidance and regulations Reviews the current state-of-the-art considerations and best practices spanning the combination product lifecycle, pre-market through post-market Reviews medical product classification and assignment issues faced by global regulatory authorities and industry The editor is a recognized international Combination Products and Medical Device expert with over 35 years of industry experience and has an outstanding team of contributors. Endorsed by AAMI â Association for the Advancement of Medical Instrumentation.
£64.88
CRC Press The Goddard Guide to Arthropods of Medical
Book SynopsisCovering all major arthropods of medical importance worldwide, this award-winning resource has established itself as a standard reference for almost 25 years. With the globilization of commerce and the world becoming more intimately connected through the everyday ease of travel, unknown arthropod species are being increasingly encountered. This means access to up-to-date, authoritative information in medical entomology has never been more important. Now in its seventh edition, this book maintains its well-acclaimed status as the ultimate easy-to-use guide to identify disease-carrying arthropods, the common signs and symptoms of vector-borne diseases, and the current recommended procedures for treatment. Includes an in-depth chapter with diagnostic aids to help physicians to recognize and accurately diagnose arthropod-related diseases and conditions more easilyUpdates all chapters with the latest medical and scientific findings, including Zika virus, red meat allergyTrade ReviewPraise for the previous edition "The sixth edition continues the previous tradition, in that the information provided is practical and presented in a format optimal for use on an as-needed basis. The addition of color photographs throughout the text (and not just an insert) is a major plus. Additional clinical case histories enliven the text. General guidelines to treatment of conditions resulting from exposure to arthropods and appropriate references to detailed material are also provided. Another aspect, the ‘Bug Coach’ CD-ROM, provides over 100 line drawings, figures, and photos in three sections: (1) arthropods, (2) arthropod-induced diseases and conditions, and (3) an identification guide. The CD also now includes a few brief instructional videos. … This text has come of age at a time when it is needed most. It will especially be valued by health care providers who find themselves in unknown territory, both geographically and medically."—Richard D. deShazo, M.D., University of Mississippi Medical Center Table of ContentsPart I Pathological Conditions Caused by Arthropods and Principles of Their Treatment 1 Principles of Treatment for Arthropod Bites, Stings, and Other Exposure 2 Allergy to Arthropods 3 Stings 4 Bites 5 Blistering, Dermatitis, and Urticaria from Contact with Arthropods 6 Myiasis (Invasion of Human Tissues by Fly Larvae) 7 Delusions of Parasitosis (Imaginary Insect or Mite Infestations) PART II Identification of Arthropods and the Diseases They Cause 8 Identification of Medically Important Arthropods 9 Clinician’s Guide to Common Arthropod Bites and Stings PART III Arthropods of Medical Importance 10 Ants 11 Bees 12 Beetles 13 Bugs (The True Bugs) 14 Caterpillars (Urticating) 15 Centipedes 16 Cockroaches 17 Earwigs 18 Fleas 19 Flies (Biting) 20 Flies (Nonbiting) 21 Flies (That Might Cause Myiasis) 22 Lice 23 Millipedes 24 Mites 25 Mosquitoes 26 Moths (Species Whose Scales or Hairs Cause Irritation) 27 Pentastomes (Tongue Worms) 28 Scorpions 29 Spiders 30 Ticks 31 Wasps (Yellowjackets, Hornets, and Paper Wasps) PART IV Personal Protection Measures against Arthropods 32 Pros and Cons of Insect Repellents 33 Arthropod-Specific Personal Protection Techniques
£43.69
Taylor & Francis Ltd Antidiabetic Medicinal Plants and Herbal
Book SynopsisDiabetes is a chronic condition associated with metabolic disorder. Persons suffering from diabetes have shown accelerated levels of blood sugar which often harms the heart, blood vessels, eyes, kidneys, and nerves. Over the past few decades, the prevalence of diabetes has been progressively increasing. Synthetic drugs are used to treat diabetic patients to help control the disorder, but it is shown that numerous medicinal plants and herbal drugs are widely used in several traditional systems of medicine to prevent and treat diabetes. They are reported to produce beneficial effects in combating diabetes and alleviating diabetes-related complications. These plants contain phtyonutrients and phytoconstituents demonstrating protective or disease preventive properties. In many developing countries, herbal drugs are recommended by traditional practitioners for diabetes treatment because the use of synthetic drugs is not affordable.Key Features:ProvidesTable of ContentsSection A - Introduction to Diabetes: An Overview. Medicinal and Herbal Plants-Based Phytochemicals Associated with Antidiabetic Response. Antidiabetic Medicinal and Herbal Plants and their Mechanisms of Action. Section B - Antidiabetic Medicinal and Herbal Plants. Babul (Acacia arabica). Bael (Aegle marmelose). Church steeples (Agrimonia eupatoria). Onion (Allium cepa). Garlic (Allium sativum). Ghrita kumara (Aloe vera). Bitterweed (Andrographis paniculata). Sugar apple (Annona squamosa). Neem (Azadirachta indica). Orchid tree (Bauhinia variegata). Red spiderling (Boerhaavia diffusa). Ash gourd (Benincasa hispida). Beetroot (Beta vulgaris). Fever nut (Caesalpinia bonducella). Bitter apple (Citrullus colocynthis). Ivy gourd (Coccinia indica). Eucalyptus (Eucalyptus globules). Banyan tree (Ficus benghalenesis). Gurmar (Gymnema sylvestre). Gurhal (Hibiscus rosa-sinesis). Sweet potato (Ipomoea batatas). Purging nut (Jatropha curcas). Mango (Mangifera indica). Karela (Momordica charantia). Mulberry (Morus alba). Kiwach (Mucuna pruriens). Black cumin (Nigella sativa). Tulsi (Ocimum sanctum). Guava (Psidium guajava). Bisasar (Pterocarpus marsupium). Anar (Punica granatum). Jamun (Syzygium cumini). Giloy (Tinospora cordifolia). Methi (Trigonella foenum-graecum). Bitter leaf (Vernonia amygdalina). Chinese date (Zizyphus spina-christi).
£147.25
Taylor & Francis Ltd Cancer Targeting Therapies
Book SynopsisThis volume in the popular series, Drugs and the Pharmaceutical Sciences, begins with the history of cancer treatment, carcinogens, and molecular mechanisms involved in cancer pathogenesis. It incudes conventional and advanced cancer therapies ranging from oral and parenteral preparations to advanced fabricated systems such as nanoparticles, liposomes, antibodies, aptamers, poly(amidoamine) and photodynamic therapies. The preparation and mechanisms of molecular targeting of cancer are presented and the authors focus on a diverse audience including undergraduates and research students.Features Timely coverage of changes in process control technology for the phamaceutical industry, a dynamic area in terms of products and manufacturing processes Provides an update on the unique requirements of these industries and how they differ from others, for example the microelectronics or specialized chemicals industries Draws on the author''s vaTable of Contents History of Cancer Therapies Cancer and Carcinogens Causes of Death from Cancer Passive Targeting Cancer Active Targeting Strategies Conventional Cancer Therapies Oral Anticancer Therapies Parenteral Anticancer Therapies Advanced Cancer Therapies The Advent of Micro and Nano-spheres for Cancer Treatment The Emergence of Liposomes in Cancer Therapy Niosomes-Based Anticancer Therapies Solid Lipid Nanoparticles-Based Anticancer Therapies Mesoporous Nanoparticles-Based Anticancer Therapies Antibody-Based Cancer Therapies Aptamer-Based Anticancer Therapies Polyamidoamines-Based Anticancer Therapies Photodynamic Therapies for Cancer Treatment
£73.14
Taylor & Francis Ltd Medical Affairs
Book SynopsisMedical Affairs is one of the three strategic pillars of the pharmaceutical and MedTech industries, but while clear career paths exist for Commercial and Research and Development, there is no formal training structure for Medical Affairs professionals. Medical and scientific expertise is a prerequisite for entry into the function, and many people transitioning into Medical Affairs have advanced degrees such as PhD, MD, or PharmD. However, these clinical/scientific experts may not be especially well-versed in aspects of industry such as the drug development lifecycle, crossfunctional collaborations within industry, and digital tools that are transforming the ways Medical Affairs generates and disseminates knowledge. This primer for aspiring and early-career Medical Affairs professionals equips readers with the baseline skills and understanding to excel across roles.Features:Defines the purpose and value of Medical Affairs and provides clear career Table of ContentsSECTION 1: MEDICAL AFFAIRS IN THE PHARMACEUTICAL AND MEDTECH INDUSTRIES Chapter 1 What Is Medical Affairs? Chapter 2 Groups and Structure of Medical Affairs Chapter 3 Medical Affairs Collaborations Across the Drug/Device Development Lifecycle Chapter 4 Measuring the Impact of Medical Affairs Chapter 5 Medical Affairs Careers SECTION 2: THE PRACTICE OF MEDICAL AFFAIRS Chapter 6 Medical Strategy and Launch Excellence Chapter 7 Evidence Generation and Real-World Evidence Chapter 8 Medical Communications Chapter 9 External Education Chapter 10 Field Medical Chapter 11 Insights Chapter 12 Medical Information Chapter 13 Patient Centricity Chapter 14 Medical Operations Chapter 15 Digital Strategy Chapter 16 Compliance Chapter 17 Rare Disease and Gene Therapy Chapter 18 Medical Affairs in MedTech
£109.25
Taylor & Francis Ltd Practical Guide to Clinical Data Management
Book SynopsisThe management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment. Groundbreaking on its initial publication nearly 14 years ago, and evolving with the field in each iteration since then, this latest volume includes revisions to all chapters to reflect the recent updates to ICH E6, good clinical practices, electronic data capture, and interactive response technologies. Keeping the coverage practical, the author focuses on the most critical information that impacts clinical trial conduct, providing a full end-to-end overview for clinical data managers.Features:Provides an introduction and background information for the spectrum of clinical data management tasks.  
£114.00
Taylor & Francis Leadership in the Pharmaceutical Industry
Book SynopsisLeadership in the Pharmaceutical Industry focuses on leadership in pharmaceutical organisations at three levels: individual, team, and organisational. At the individual level, it covers leadership basics, theories, types of leaders, differences between leader and manager, leadership traits and skills, and systems thinking. At the team level, it explores leadership styles, the leader's interaction with the team, and employee motivation, including the use of intrinsic motivational factors. At the organisational level, it examines the leader's role in creating and maintaining organisational culture, forming and implementing organisational strategy, and managing organisational changes.The book also addresses the specifics of the pharmaceutical industry, including the types and characteristics of innovations and the ethics of leader behaviour, emphasising the importance of ethical leadership. Notably, leadership issues are illustrated with practical cases featuring prominent leaders such as Paul Janssen, Daniel Vasella, Charles Walgreen III, John C. Martin, Roy Vagelos, Albert Bourla, Kiran Mazumdar-Shaw, and Filya Zhebrovska. These leaders were or are involved in creating, manufacturing, and providing patients with pharmaceutical products.The book is designed to benefit readers from various business sectors, with the primary audience being academics, students, and individuals interested in leadership in the pharmaceutical industry.
£50.34
