Oncology Books

Book SynopsisThis textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. Table of Contents

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Book SynopsisThis book comprehensively covers the techniques available for robot- assisted prostatectomy. Chapters feature detailed descriptions of how to successfully perform a variety of relevant techniques including the reconstruction of continence mechanisms and the use of the transperitoneal RALP anterior approach. Potential complications, preoperative and postoperative management strategies are also discussed, enabling the reader to develop a thorough understanding of how to apply a range of relevant methodologies into their day-to-day clinical practice and avoid commonly encountered pitfalls.Robot-Assisted Radical Prostatectomy: Advanced Surgical Techniques provides a practically applicable resource for all practicing and trainee urologists seeking a detailed overview of the latest advances in robot-assisted surgical procedures and current management strategies applicable to prostatectomy. Table of ContentsAn historical perspective of RALP.- Overviewing Robotic Surgical Technique.- How to start a RALP program.- Surgical anatomy of the prostate.- Preoperative imaging.- MRI imaging.- PET/CT imaging.- Transperitoneal RALP anterior approach.- Posterior approach to seminal vesicles .- Anatomical bladder neck dissection.- Retrograde Release of NVB with preservation of DVC.- Introperative assessment of surgical margins.- NEUROsafe.- Ex vivo fluorescence confocal microscopy.- Extra-fascial (non-nerve sparing).- Apical dissection.- Reconstruction of continence mechanisms.- Urethro-vesical.- Urethral suspension.- Bladder neck intussusception.- Posterior reconstruction.- CORPUS .- ARVUS .- Chinese technique.- Total anatomical reconstruction.- Transperitoneal RALP Retzius-sparing approach.- Bocciardi Technique.- Yonsei Technique.- Vattikuti technique.- Extra-peritoneal RALP.- Rochester technique.- Chinese Technique.- CUF Technique.- Pelvic lymph node dissection.- Predictive models.- Extended lymphadenectomy technique.- Fluorescence guided node dissection.- PSMA MRI fusion guided dissection.- Radio guided Surgery in Recurrent Prostate Cancer.- Techniques to prevent lymphocele formation in RALP.- Four-point Peritoneal Flap Fixation.- PLEAT.- Hernia repair during RALP.- Perineal RALP.- Tugcu Bakirkoy Technique.- Changhai technique.- Single-site RALP.- Cleveland Clinic technique.- UIC technique.- Changhai technique.- RALP in difficult situations.- Large median lobe.- Large volume gland with small pelvis.- Patients with previous BPH surgery.- Salvage RALP.- RALP for oligo-metastatic disease.- Augmented reality RALP.- Robot assisted partial prostatectomy for anterior cancer.- Complications in RALP: prevention and management.- Functional recovery after RALP.- Erectile function.- Continence.- Robotic training for RALP.

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Book SynopsisThis practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions considered are extremity soft tissue sarcomas, retroperitoneal soft tissue sarcomas, bone sarcomas, uterine sarcomas, chordomas, pediatric sarcomas, squamous cell carcinomas, basal cell carcinomas, melanomas, Merkel cell carcinomas, and cutaneous lymphomas. Detailed attention is devoted to the issues and considerations of relevance in everyday practice when treating these diseases. The use of multiple radiotherapy techniques and procedures, including IMRT, brachytherapy, radiosurgery, and particle therapy, is fully explained, and the role of radiotherapy in combination with chemotherapy and emerging therapeutics such as immunotherapy and biologic anticancer agents is also addressed. The book will be of high value for practicing radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, trainees, and other medical professionals.Table of ContentsPART I: Sarcomas1. Extremity soft tissue sarcoma 2. Retroperitoneal soft tissue sarcoma 3. Gynecologic sarcomas 4. Bone sarcomas 5. Chordomas 6. Oligometastatic sarcomas 7. Pediatric sarcomas 8. Particle therapy for sarcomas 9. Chemotherapy / radiosensitizers PART II: Other soft tissue tumors: 10. Desmoid fibromatosis 11. Hemangiopericytomas / solitary fibrous tumors 12. Angiosarcomas 13. Dermatofibrosarcoma protuberans PART III: Skin cancers: 14. Squamous cell carcinomas 15. Basal cell carcinomas 16. Melanomas 17. Merkel cell carcinomas 18. Cutaneous lymphomas

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Book SynopsisThis open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. This conference comes at an especially important time when Latinos – the largest and youngest minority group in the U.S. – are expected to face a 142% rise in cancer cases in the coming years. Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. Each chapter summarizes the presentation and includes current knowledge in the specific topic areas, identified gaps, and opportunities for future research. Topics explored include: Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Optimizing Engagement of the Latino Community in Cancer Research Latino Population Growth and the Changing Demography of Cancer Implementation Science to Enhance the Value of Cancer Research in Latinos A Strength-Based Approach to Cancer Prevention in Latinxs Overcoming Clinical Research Disparities by Advancing Inclusive Research Advancing the Science of Cancer in Latinos: Building Collaboration for Action will appeal to a wide readership due to its comprehensive coverage of topics ranging from basic science and community prevention research to clinical practice to policy. The book is an essential resource for physicians and other medical professionals, researchers, scientists, academicians, patient advocates, and students. It also will appeal to policy-makers, NCI-designated cancer centers, academic centers, state health departments, and community organizations.Table of ContentsPart I Introduction 1..... Advancing the Science of Cancer in Latinos Amelie G. Ramirez, Edward J. Trapido Part II Health Threats in the Latino Community 2..... Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Paul D. Juarez, Darryl Hood, Min-ae Song, Aramandla Ramesh 3..... Population Health Challenges for Latinos in the US Alexander N. Ortega Part III Vulnerable Populations and Cancer Health Disparities 4..... Acute and Long-Term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children Austin L. Brown, Kimberly P. Raghubar, Michael E. Scheurer, Philip J. Lupo Part IV Cancer Outcomes and Survivorship in Latinos 5..... Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Dinorah Martinez-Tyson, Erik L. Ruiz 6..... Cancer Care Delivery Among Breast Cancer Patients: Is It the Same for All? Catalina Malinowski, Mariana Chavez-MacGregor Part V Cancer in the Era of Precision Medicine 7..... Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women Lizeth I. Tamayo, Elam Day-Friedland, Valentina A. Zavala, Katie M. Marker, Laura Fejerman 8..... Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy Kenneth S. Ramos, Stefano Guerra, Randa El-zein Part VI Engaging Latinos in Cancer Research 9..... Optimizing Engagement of the Latino Community in Cancer Research Lourdes Baezconde-Garbanati, Bibiana Martinez, Carol Ochoa, Sheila Murphy, Rosa Barahona, Carolina Aristizabal, Yaneth L. Rodriguez Part VII Emerging Policies Impacting Latino Care 10.... Latino Population Growth and the Changing Demography of Cancer Rogelio Sáenz 11.... Financial Hardship, Food Insecurity, and Forgone Medical Care Jean A. McDougall, Shoshana Adler Jaffe, Dolores D. Guest, V. Shane Pankratz, Charles L. Wiggins, Angela L. W. Meisner, Andrew L. Sussman Part VIII Implementation Science, Innovative Technologies and the Future of Cancer Care 12.... Implementation Science to Enhance the Value of Cancer Research in Latinos: A Perspective from the National Cancer Institute Gila Neta 13.... Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients Sharon H. Baik, Joanna Buscemi, Laura B. Oswald, Diana Buitrago, Judith Guitelman, Francisco Iacobelli, Melissa A. Simon, Frank J. Penedo, Betina Yanez Part IX Latino Lifestyles: Acculturation, Nutrition, and Health 14.... Impact of Obesity and Related Factors in Breast Cancer Survivorship Among Hispanic Women Elisa V. Bandera, Chi-Chen Hong, Bo Qin 15.... A Strength-Based Approach to Cancer Prevention in Latinxs Marisa S. Torrez-Ruiz, Sandra Soto, Nanette V. Lopez, Elva M. Arredondo Part X Advances in Cancer Therapy and Clinical Trials 16.... Overcoming Clinical Research Disparities by Advancing Inclusive Research Melissa Gonzales Part XI HPV Vaccination for Cancer Prevention 17.... The Road to Cervical Cancer Elimination Anna R. Giuliano Part XII Latino Cancer Health Disparities: Moving Forward 18.... Looking Forward: Continuing the Collaboration for Action Amelie G. Ramirez, Edward J. Trapido Appendix A: Advances in Biology and Treatment of Cancer Appendix B: Cancer Epidemiology and Prevention Appendix C: Engaging Latinos in Research Across the Cancer Continuum Appendix D: Living with and Beyond Cancer: Taking Action to Improve Outcomes

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Book SynopsisThis open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. This conference comes at an especially important time when Latinos – the largest and youngest minority group in the U.S. – are expected to face a 142% rise in cancer cases in the coming years. Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. Each chapter summarizes the presentation and includes current knowledge in the specific topic areas, identified gaps, and opportunities for future research. Topics explored include: Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Optimizing Engagement of the Latino Community in Cancer Research Latino Population Growth and the Changing Demography of Cancer Implementation Science to Enhance the Value of Cancer Research in Latinos A Strength-Based Approach to Cancer Prevention in Latinxs Overcoming Clinical Research Disparities by Advancing Inclusive Research Advancing the Science of Cancer in Latinos: Building Collaboration for Action will appeal to a wide readership due to its comprehensive coverage of topics ranging from basic science and community prevention research to clinical practice to policy. The book is an essential resource for physicians and other medical professionals, researchers, scientists, academicians, patient advocates, and students. It also will appeal to policy-makers, NCI-designated cancer centers, academic centers, state health departments, and community organizations.Table of ContentsPart I Introduction 1..... Advancing the Science of Cancer in Latinos Amelie G. Ramirez, Edward J. Trapido Part II Health Threats in the Latino Community 2..... Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Paul D. Juarez, Darryl Hood, Min-ae Song, Aramandla Ramesh 3..... Population Health Challenges for Latinos in the US Alexander N. Ortega Part III Vulnerable Populations and Cancer Health Disparities 4..... Acute and Long-Term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children Austin L. Brown, Kimberly P. Raghubar, Michael E. Scheurer, Philip J. Lupo Part IV Cancer Outcomes and Survivorship in Latinos 5..... Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Dinorah Martinez-Tyson, Erik L. Ruiz 6..... Cancer Care Delivery Among Breast Cancer Patients: Is It the Same for All? Catalina Malinowski, Mariana Chavez-MacGregor Part V Cancer in the Era of Precision Medicine 7..... Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women Lizeth I. Tamayo, Elam Day-Friedland, Valentina A. Zavala, Katie M. Marker, Laura Fejerman 8..... Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy Kenneth S. Ramos, Stefano Guerra, Randa El-zein Part VI Engaging Latinos in Cancer Research 9..... Optimizing Engagement of the Latino Community in Cancer Research Lourdes Baezconde-Garbanati, Bibiana Martinez, Carol Ochoa, Sheila Murphy, Rosa Barahona, Carolina Aristizabal, Yaneth L. Rodriguez Part VII Emerging Policies Impacting Latino Care 10.... Latino Population Growth and the Changing Demography of Cancer Rogelio Sáenz 11.... Financial Hardship, Food Insecurity, and Forgone Medical Care Jean A. McDougall, Shoshana Adler Jaffe, Dolores D. Guest, V. Shane Pankratz, Charles L. Wiggins, Angela L. W. Meisner, Andrew L. Sussman Part VIII Implementation Science, Innovative Technologies and the Future of Cancer Care 12.... Implementation Science to Enhance the Value of Cancer Research in Latinos: A Perspective from the National Cancer Institute Gila Neta 13.... Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients Sharon H. Baik, Joanna Buscemi, Laura B. Oswald, Diana Buitrago, Judith Guitelman, Francisco Iacobelli, Melissa A. Simon, Frank J. Penedo, Betina Yanez Part IX Latino Lifestyles: Acculturation, Nutrition, and Health 14.... Impact of Obesity and Related Factors in Breast Cancer Survivorship Among Hispanic Women Elisa V. Bandera, Chi-Chen Hong, Bo Qin 15.... A Strength-Based Approach to Cancer Prevention in Latinxs Marisa S. Torrez-Ruiz, Sandra Soto, Nanette V. Lopez, Elva M. Arredondo Part X Advances in Cancer Therapy and Clinical Trials 16.... Overcoming Clinical Research Disparities by Advancing Inclusive Research Melissa Gonzales Part XI HPV Vaccination for Cancer Prevention 17.... The Road to Cervical Cancer Elimination Anna R. Giuliano Part XII Latino Cancer Health Disparities: Moving Forward 18.... Looking Forward: Continuing the Collaboration for Action Amelie G. Ramirez, Edward J. Trapido Appendix A: Advances in Biology and Treatment of Cancer Appendix B: Cancer Epidemiology and Prevention Appendix C: Engaging Latinos in Research Across the Cancer Continuum Appendix D: Living with and Beyond Cancer: Taking Action to Improve Outcomes

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Book SynopsisThis open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.Table of ContentsHistory of Radiation Biology.-Basic Concepts of Radiation Biology.-Molecular Radiation Biology.-Mechanistic, Modelling and Dosimetric Radiation Biology.-Clinical Radiobiology for Radiation Oncology.-Radiobiology of Combining Radiotherapy with other Cancer Treatment Modalities.-Individual Radiation Sensitivity and Biomarkers.-Radiobiology of Accidental, Public and Occupational Exposures.-Environmental Radiobiology.-Space Radiobiology.-Radioprotectors, Radiomitigators and Radiosensitizers.-Ethical, Legal, Social and Epistemological Considerations of Radiation Exposure.

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Book SynopsisThis book will offer a practical guide for the surgical management of oncologic emergencies, that pose great challenges to both surgeons and oncologists. Combining the knowledge of experienced surgeons and oncologists, it describes the experience gained from daily life into a tertiary hospital. Every chapter will be focused on radical treatment of primary tumors, metastatic disease and palliation, and will include an “Highlight” section with 4-5 key messages at the beginning of each chapter, whereas at the end a flow-diagram will be employed to summarize the subject discussed topic. Every chapter will be written by at least two authors, including a surgeon and an oncologist, to guarantee a 360 degrees analysis of each topic. This work will benefit both surgeons and oncologists: surgeons will found in it a step to step practical tool that helps the decision making process, while oncologists will find interesting indications about how and when to involve a general surgeon into the management of an oncologic emergent condition.Table of ContentsHead and neck.- Adrenal glands.- Lung.- Esophagus.- Stomach.- Duodenum.- Small Bowel.- Right colon.- Appendix.- Left colon.- Rectum.- Liver.- Pancreas.- Gallbladder and biliary tract.- Spleen.- Uterus and Ovaries.- Kidney.- Urinary Bladder.- Peritoneal carcinosis.- Miscellaneous rare malignancies - Intra-abdominal lymphomas.- Miscellaneous rare malignancies – GIST.- Miscellaneous rare malignancies – Desmoplastic.- Miscellaneous rare malignancies – Sarcomas.- Miscellaneous rare malignancies - Pseudomixoma peritoneum.- Ethical issues.

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Book SynopsisThis book provides a practical, evidence-based approach to controversies in the management of thyroid nodules and differentiated thyroid cancer (DTC). Thyroid nodules are a commonly encountered clinical entity, identified in 2-6% of the population by palpation, and 20-35% by ultrasound. DTC is the solid organ cancer with the most rapidly increasing incidence (>50,000 new cases in the U.S. annually). Despite extensive research and multiple published comprehensive practice guidelines, numerous controversies remain within this field covering a wide range of issues, including incidence and epidemiology, radiographic evaluation, criteria for needle biopsy, cytopathologic and molecular diagnostics, active surveillance vs. operation for low-risk tumors, extent of surgery, indications for radioactive iodine treatment and external beam radiation, and optimal protocols for follow-up. The book takes a case-based approach: each chapter will begin with a patient presentation highlighting a particular controversial subject in thyroid nodules and DTC. The remainder of the chapter discusses the controversy within the context of current scientific understanding and clinical practice, using the latest evidence-based practice guidelines. Chapters conclude with a final review and discussion of the opening case, with options and recommendations for next steps provided. The recommendations are evidence-based and practical, intended to help guide practitioners in their ongoing care of patients with thyroid nodules and DTC. Each chapter was written by a recognized expert in the area of controversy, including endocrine surgeons, endocrinologists, radiologists, medical oncologists, and nuclear medicine specialists. Controversies in Thyroid Nodules and Differentiated Thyroid Cancer: A Case-Based Approach is an excellent guide for oncologists, endocrinologists, otorhinolaryngologists, surgeons, and practitioners of all types that care for patients with thyroid nodules and DTC.Table of ContentsChapter 01: Incidence and Epidemiology of Differentiated Thyroid Cancer: Is thyroid cancer incidence truly increasing, or is it simply a finder effect?Chapter 02: Criteria for Fine-Needle Aspiration Biopsy in Thyroid NodulesChapter 03: Preoperative Molecular Testing for Indeterminate Thyroid NodulesChapter 04: Active Surveillance of Low-Risk Differentiated Thyroid CancerChapter 05: Preoperative Laryngoscopy in Thyroid Surgery PatientsChapter 06: Radiofrequency Ablation for Thyroid NodulesChapter 07: Management of low-risk papillary thyroid cancer in a patient with familial non-medullary thyroid cancer Chapter 08: Intraoperative Nerve Monitoring in Thyroid OperationsChapter 09: Extent of Surgery for Low-Risk Papillary Thyroid CancerChapter 10: Surgical Management of Locally Advanced Thyroid Cancer with Tracheal InvasionChapter 11: Management of Central Neck Nodes in Papillary Thyroid CancerChapter 12: Impact of Surgeon Volume in Thyroid OperationsChapter 13: Intraoperative/Postoperative Calcium Management in ThyroidectomyChapter 14: Indications for Radioactive Iodine Therapy in Thyroid Cancer PatientsChapter 15: Recurrent Nodal Metastases of Papillary Thyroid CancerChapter 16: Management of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Features (NIFT-P)Chapter 17: Timing of long-term post-operative surveillance for low-risk differentiated thyroid cancerChapter 18: External-Beam Radiation for Patients with Differentiated Thyroid Cancer – Is There a Role?

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Book Synopsis Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents.This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.Table of ContentsResectable Pancreatic Cancer: Neoadjuvant and Adjuvant Therapy.- Borderline Resectable and Locally Advanced Pancreatic Cancer.- Radiation Therapy for Pancreatic Cancer: Current and Evolving Paradigms.- Therapies for Metastatic Pancreatic Cancer.- Targeted Therapies for Pancreatic Cancer.- Immunotherapy for Pancreatic Cancer.- Liquid Biopsies for pancreatic cancer: Is it ready for prime time?.- Supportive Care challenges and management in Pancreatic Cancer.- Physical activity and nutrition optimization in pancreatic cancer.

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Book SynopsisMuch research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 20th volume of a continuing series.Table of Contents1.- Krishna Kumar Haridhasapavalan , Atreyee Borthakur , Rajkumar P Thummer - Direct Cardiac Reprogramming: Current Status and Future Prospects2.- Ayça Aslan, Selcen Arı Yuka - Stem Cell-Based Therapeutic Approaches in Genetic Diseases3.- Akshaya Upadhyay , Uyen M N Cao , Arvind Hariharan , Akram Almansoori , Simon D Tran - Gene Therapeutic Delivery to the Salivary Glands4.- Meryem Osum , Rasime Kalkan -Cancer Stem Cells and Their Therapeutic Usage5.- Ozlem Aybuke Isik , Onur Cizmecioglu -Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease6.- Giulia Silvani , Valentin Romanov, Boris Martinac -Sounding a New Era in Biomechanics with Acoustic Force Spectroscopy7.- Akram Abdo Almansoori , Arvind Hariharan , Uyen M N Cao , Akshaya Upadhyay , Simon D Tran - Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections8.- Toshifumi Yamashiro , Toshihiro Kushibiki , Yoshine Mayumi , Masato Tsuchiya , Miya Ishihara , Ryuichi Azuma - Negative-Pressure Wound Therapy: What We Know and What We Need to Know9.- Aziz Rodan Sarohan , Sait Edipsoy , Zeynep Gürsel Özkurt, Can Özlü , Ayça Nur Demir , Osman Cen - Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mycormycosis (Black Fungus): An Analytical Perspective10.- Thudzelani Takalani Austin Malise , Ekene Emmanuel Nweke , Mutsa M Takundwa , Pascaline Fonteh Fru , Deepak B Thimiri Govinda Raj - Treatment Strategies for Multiple Myeloma Treatment and the Role of High-Throughput Screening for Precision Cancer Therapy

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Book SynopsisOncology is a field characterized as “medicine of high complexity” and cancer is generally regarded as a complex system. Therefore, it cannot be classified and treated according only to its biology. Even though research on the biology of cancer has increased and more studies have been published, the related sociological, political and economic dimensions, as well as mathematical models that predict whether this condition will take one course or another, have often been neglected. The Invisible Hand of Cancer—The Complex Force of Socioeconomic Factors in Oncology Today unfolds the variables behind the biological disease, exploring the social aspects and presenting cancer as a model inside of the Complexity Theory. Cancer is a generic word for more than 200 diseases. In a wider view of cancer treatment, the various factors of cancer interact in multiple ways and it is a difficult task to identify and understand all the possible combinations in this system. All these variables and how they interact can be defined as the invisible hand of cancer. This book does not intend to be an exhaustive analysis of these aspects. It is a door being opened to the cancer research journey, along the years and beyond its biology. It will also discuss how social behavior can interfere in the evolution of cancer treatment, as a result of society’s way of thinking and choices, thus the importance of truly addressing cancer as an intricate system and a public health issue. After the success of my children’s books about cancer (Chubby’s Tale: The true story of a teddy bear who beat cancer, Bald is Beautiful: A letter for a fabulous girl, Cancer Daily Life, and What is Cancer?: A book for kids), I have developed a passion for writing about science in a simple way for non-scientist readers. I have also worked to build a career as a writer, communicating with patients, advocates, and oncology and pediatric oncology professionals, mostly on Twitter. Everyone knows someone who has or had cancer, so more and more popular science books on this topic are becoming bestsellers. This book is directed to a general audience and follows scientific standards, encompassing high-quality data, but in an easy-to-read format. Furthermore, it will raise awareness and show how simple actions such as not judging patients and not spreading false popular beliefs can contribute to achieve a new milestone in the cancer journey.Table of Contents1. The Blame Game This chapter will address how our society often blames cancer patients, associating habits and some types of cancer. It will measure the psychological impacts, question and show data (in a comprehensible way) to conclude what habits and how much they really can cause cell mutation and cancer. The blame game's sociological aspects are analyzed, which is a psychological and cultural behavior (proved by consistent data) of judging people by their type of cancer. Confronting popular habits and theories with science, the first chapter will address the question of how much habits can really interfere with the complex mechanisms of cancer development, and how fair is the way cancer is approached in the media and society. More than that, it opens the discussion about how it interferes in treating cancer as a public policy. 2. The Broken Machine This chapter is about the biology of cancer and how our repair mechanisms work to avoid cancer development. The various mechanisms of repair are listed and it is explained why they can sometimes not function properly. 3. Healthy and Fitness — to be, or not to be, that is the question This chapter confronts common knowledge about what is considered healthy. It includes data, as well as mechanisms of mutation of some substances (in a reader-friendly way), and shows how these substances can easily be avoided in daily life. It also discusses the safety of some preservatives in food and other substances that are approved in many countries. 4. Chaos and Complexity This chapter addresses physical chemistry in an easy-to-read format for non-scientists. It explains the complex organization of cancer, how it can adapt itself to the body, and if its biology tends to chaos. 5. Life and Death Are Made Of Five Letters: A, T, C, G, U This chapter is about genetics: DNA, RNA, and the code of life and death. 6. Panem et Circenses This chapter includes an analysis of news and popular information about cancer and their social effects, detailing how the popular excitement over false promises influences government decisions and other cause-effect analyses. 7. Metastasis — When biology favors that cancer follows its way This chapter highlights the biology of metastasis and the many characteristics that lead a patient to develop metastatic cancer. 8. Treating Cancer This chapter presents drugs, radiotherapy and surgery in cancer treatments. It discusses why each treatment works for some patients and not for others. Stem cell transplantation, CART-cells and other relatively new therapies are also featured, describing how individual biology interferes. Special attention is given to CART-cells and cellular therapies.9. Cancer and Incarceration Incarcerated patients are a specific population and often have their needs neglected, representing a major health issue. Therefore, this chapter will discuss health and cancer in the prison system of the United States. 10. Cancer in Germany, the US, and Brazil This chapter will compare cancer treatment, public policies, health systems, financial toxicity and other social factors related to cancer in Germany, the United States and Brazil. 11. When the Same Way is Longer: Cancer Social Determinants This chapter will analyze the social determinants of cancer and how healthcare is managed in different countries. In many developing countries cancer is not regarded as a national priority since the major health problems are related to malnutrition, deaths of neonates during delivery and neglected infectious diseases, such as malaria. Another issue linked to social conditions is the choice of health insurance, which will also be addressed in this chapter. 12. Financial Toxicity This chapter will address the high-cost of cancer treatments and how it affects patients and their caregivers. 13. When the Same Disease Can Have Different Psychological Impacts in Different Countries This chapter will compare the psychological impacts of cancer in different countries.

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Book SynopsisEpidemiology, Presentation, and Evaluation.- Pathology of Neuroblastoma.- Genetic Predisposition.- Part I: Evolving Concepts in Neuroblastoma Pathogenesis (Seed):Tumor Genomics: Copy Number Alterations.- Tumor Genomics: Epigenetics.- Tumor Genomics: Genomic Regulation .- Tumor Metabolism.- Part II: Evolving Concepts in Neuroblastoma Immunology and Tumor Microenvironment (Soil): Neuroblastoma Tumor Microenvironment - Adaptive and Innate Immunity.- Neuroblastoma Tumor Microenvironment Non-Immune Cells and Exosomes.- Part III: Evolving Concepts in Neuroblastoma Precision Medicine: Targeting the Seed and the Soil: Advances in evaluating tumor burden.- Therapeutically Actionable Genetic Aberrations.- Re-engaging the Immune System:  Future of Immunotherapy.- Future of Clinical Trials and Application of Precision Medicine.- Summary and the Next 10 Years.      <

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Book SynopsisI. The history of IA drug delivery (Chapter 1).-II. The pharmacokinetics of intraarterial drugs.-The conventional approach to modeling IA drug delivery (Chapter 2).-Flow dynamics of regional drug delivery (Chapter 3).-Flow-controlled kinetics of intraarterial drugs (Chapter 4).-Optical methods to investigate ultrafast IA drug kinetics (Chapter 5).-III. Current applications of IA drugs.-Specific cancers.- Retinoblastomas (Chapter 6).-Metastatic liver cancer ((Chapter 7).-Glioblastomas (Chapter 8).-Locally invasive breast cancers (Chapter 9).-Pelvic malignancy (Chapter 10).-Head and neck tumors (Chapter 11).-Neurological diseases.-Treatment of cerebral vasospasm (Chapter 12).-Stroke and local brain cooling (Chapter 13).-Blood-brain barrier disruption (Chapter 14).-Intraarterial thrombolysis for peripheral vascular disease (Chapter 15).-IV. Experimental applications of IA drugs.-Nanoparticle delivery (Chapter 16).-Carrier-mediated delivery (Chapter 17).-Gene delivery (Chapter 18).-Stem cell delivery (Chapter 19).-V. Technologies to deliver IA drugs.-The development of future intraarterial drugs (Chapter 20).-Balloon occluding catheters for drug delivery (Chapter 21).-Infusion pumps design and challenges (Chapter 22).-Robotic endovascular surgery (Chapter 23).-Self-navigation and artificial intelligence (Chapter 24).-VI. Conclusion: The future of intraarterial Drug Delivery (Chapter 25).

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Book Synopsis1. Overview on Cancer Biology and cancer hallmarks.- 2. Introduction to Seven “R”s of Radiobiology.- 3. Radiosensitivity and its contributing biologic factors.- 4. Innovative Strategies to Enhance Radiosensitivity: Hyperthermia, Nanoparticles, and DNA Repair Inhibition.- 5. Role of Tumor-Initiating Stem Cells in Tumor Resistance and Relapse.-  6. Cancer Cell’s Fates upon Radiation.- 7. Overview of Radiotherapy Techniques and Modalities: Conventional and Modern Approaches.-  8. Recent Advances in Radiotherapy of Breast cancer.-  Chapter 9 Advances in Radiotherapy of Gastrointestinal Cancers.-  10. Recent Advances in Radiotherapy of Lung Cancer.-  11. Advances in Radiotherapy of Genitourinary Cancers.-  12. Advances in Radiotherapy of Brain Tumors.-  13.  Advances in Head and Neck Cancer.- 14. Application of radiotherapy in oligometastatic disease.-  15. Emerging Role of FLASH Radiotherapy.- 16. Novel Approaches to Counteract Radiotherapy Toxicities: Focusing on Radioprotectors and Radiation Mitigators.- 17. Advances in Radiotherapy using Artificial Intelligence.- 18. Radiogenomics: A Potential Approach for Personalized radiotherapy. 19. The Emerging role of Microbiome in Radiation Research.- 20. Future Directions in Radiobiology and Clinical Radiation Oncology.

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Book Synopsissee attachment.

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Book SynopsisThe subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio-, lipo-, cotyledonoid, cellular, mitotically active, epithelioid and myxoid leiomyoma, leiomyoma with bizarre nuclei), atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant potential), and disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, and intravenous leiomyomatosis. Furthermore, endometrial stromal tumors – endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate surgical therapeutic measures under the assumed diagnosis of leiomyoma, and includes a diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.

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Book SynopsisAll the information needed for successful diagnosis and management of breast carcinoma Focused on a modern, interdisciplinary approach to diagnosing and managing diseases of the breast, this concise book builds on the high standard set in the previous edition. It provides a complete foundation in the basic principles, radiologic appearance and underlying pathology of breast disease, without overwhelming non-pathologist members of the team with excessive detail. For effective communication at every level, Practical Breast Pathology, Second Edition provides the clear information, case examples and superb illustrations that make it an ideal clinical problem solver. Special features of the second edition: High-quality examples of modern multimodality radiology (digital mammography, ultrasound and magnetic resonance imaging) correlated with large-format 2D and 3D histologic slides New findings on such clinically important topics as the lobar nature of breast carcinoma, multifocality, diffuse carcinomas and extent of disease, concept of the sick lobe and more Introduction of the molecular classification of invasive breast cancer Discussion of prognostic and predictive factors in breast carcinoma, such as hormone receptors and HER2 status Updates on preoperative diagnosis, including intact biopsy and radiologic assessment of the extent and distribution of lesions Enriched with new information and stunning illustrations in every chapter, Practical Breast Pathology, Second Edition is a key link in the exchange between pathologists, radiologists, oncologists and breast surgeons, as well as residents and trainees. It provides an essential framework for understanding the mammographic-pathologic correlation, leading to increased cooperation among clinical team members and significantly improved outcomes for patients.Table of Contents1. Normal Breast Tissue or Fibrocystic Change? 2. General Morphology of Breast Lesions 3. Hyperplastic Changes with and without Atypia 4. Ductal Carcinoma In Situ 5. The Most Common Types of Invasive Breast Carcinoma 6. The Most Common Benign Lesions and their Borderline and Malignant Counterparts 7. Fine-Needle Aspiration or Core Biopsy: A Preoperative Diagnostic Algorithm 8. The Postoperative Workup 9. Assessment of the Most Important Prognostic Parameters 10. Case Reports

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Book SynopsisDespite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function. Special features: Brings together all the current evidence and expertise on the epidemiology, risk factors, clinical and imaging evaluation, and management of recurrent head and neck cancer tumors Includes both curative and palliative approaches, and discusses surgical, radiotherapeutic, and chemotherapeutic strategic options Contains substantial contributions by specialists in speech and language therapy, palliative care, psychology, epidemiology, and clinical cancer nursing to provide a holistic, multidisciplinary approach to the management of recurrence of head and neck cancers Brings the decision-making process to life with illustrative case studies that contain patient histories, clinical findings, treatment planning, and documented results The combination of the most recent clinical advances with the latest thinking in the field makes this book an essential resource for all head and neck surgeons, clinical oncologists, radiation oncologists, nurse practitioners, allied health professionals and senior trainees working to improve patient management and outcomes in this challenging arena.

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Book SynopsisThe first volume of this updated and revised edition deals with the surgical resection of intracranial tumors. Individual chapters focus on specific intracranial regions, and provide neuroanatomic descriptions of all the major neurosurgical approaches in detail.Table of Contents1 Supratentorial Tumors 2 Tumors of the Base of the Skull 3 Infratentorial Tumors

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Book SynopsisThis textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.Table of ContentsHead and Neck Cancer: Nasopharynx.- Oropharynx Cancer.- Early Larynx.- Advanced larynx.- Hypopharyngeal Cancer.- Oral Cavity Cancer.- Paranasal Sinuses.- Major Salivary gland.- Thyroid Cancer.- Cranial Nerves.- Unknown Primary.- Head and Neck.- Neck.- Breast Cancer: Early Breast Cancer.- Locally Advanced Breast.- Thorax: Locally Advanced NSCLC &SCLD.- SBRT and post-OP NSCLC.- Gastrointestinal Cancer: Esophagus.- Gastric.- Pancreatic.- HCC/Cholangiocarcinoma.- Rectal Cancer.- Anal Cancer.- Gynecological Cancer: Cervical Cancer.- Endometrial Cancer.- Ovarian Cancer.- Vaginal Cancer.- Vulvar Cancer.- Genitourinary Cancer: Prostate Cancer.- Bladder Cancer.-Seminoma .- CNS: Brain Metastasis.- Benign.- Low and High Grade Glioma.- Lymphoma: Hodgkin's Disease.- Non-Hodgkin's Disease.- Musculoskeletal.- Pediatrics: Sarcoma.- Pediatric CNS.

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Book SynopsisThis book looks at specific vascular surgery questions that have arisen and where careful analysis is given according to the level of supporting evidence available. As new technology is introduced to treat the cardiovascular system, alternative therapies begin to challenge and also complement traditional vascular surgery. All chapters contain the PICO table to summarise specific characteristics relative to the questions posed in each chapter.Difficult Decisions in Vascular Surgery- An Evidence-Based Approach is a current and timely reference source for practicing surgeons, surgeons in training, and educators, that describes the recommended ideal approach, rather than customary care, in selected clinical situations.Trade Review“This is a useful resource for vascular trainees or vascular attendings throughout their careers as they face difficult situations that they do not encounter on a routine basis. … This is an accessible and well‐organized resource for dissecting the components of decision-making for clinical scenarios in vascular surgery. It provides a useful overview of the literature for each scenario and management recommendations graded by level of evidence. I found it to be a good resource.” (Katherine Hekman, Doody's Book Reviews, April, 2017)Table of ContentsSection 1: Aortic Disease Ch. 1: In patients with Acute Type B Aortic dissection, do current operative therapies reduce complications compared to medical management? Ch. 2: In patients with a Chronic Type B dissection, does Endovascular treatment reduce long term complications? Ch.3: In patients with a retrograde Type A Aortic dissection, does treatment like a type B Aortic dissection improve outcomes? Ch.4: In patients with small AAA, does medical therapy prevent growth? Ch.5: Challenging AAA Neck Anatomy: Does the Fenestrated or Snorkel/Chimney Technique Improve Mortality and Freedom from Reintervention Relative to Open Repair? Ch.6: In patients who require Hypogastric artery coverage to treat an AAA with EVAR, does preservation improve outcomes when compared to exclusion of the vessel? Ch.7: In patients with aortic graft infections, does EVAR improve long term survival compared to open graft resection? Ch.8: Does EVAR improve outcomes or quality of life in patients unfit for open surgery? Ch.9: In patients with type 2 endoleaks does intervention reduce aneurysm related morbidity and mortality compared to observation? Ch.10: Ruptured Abdominal Aortic Aneurysm Treated with Endovascular Repair; Does Decompressive Laparotomy Result in Improved Clinical Outcomes? Ch.11: In a Patient with Blunt Traumatic Aortic Injury, Does TEVAR Improve Survival Compared to Open Repair or Expectant Management? Section 2: Lower Extremity Arterial Disease Ch.12: In patients with Aortoiliac occlusive disease, does Endovascular repair improve outcomes when compared to open repair? Ch.13: In Patients with Aortoiliac Occlusive Disease, Does Extra-anatomic Bypass Improve Quality of Life and Limb Salvage? Ch.14: In Patients with Critical Limb Ischemia Does Bypass Improve Limb Salvage and Quality of Life When Compared to Endovascular Revascularization? Ch.16: In the patient with Profunda artery disease, is open revascularization superior to endovascular repair for improving rest pain? Ch.17: In patients with limb-threatening vascular injuries, is there a role of prophylactic fasciotomy to reduce ischemic injury? Ch.18: In patients with Popliteal Entrapment Syndrome, does surgery improve quality of life? Section 3: Mesenteric Disease Ch.19: In patients with Acute Mesenteric Ischemia does an endovascular or hybrid approach improve morbidity and mortality compared to open revascularization? Ch.20: Chronic Mesenteric Arterial Disease Does an endovascular/hybrid approach improve morbidity and mortality as compared to open revascularization? Ch.21: In patients with mesenteric ischemia is single vessel reconstruction equivalent to multiple vessel revascularization? Ch.22: In patients with celiac artery compression syndrome, does surgery improve quality of life? Ch.23: In patients with the Superior Mesenteric Artery syndrome is Enteric Bypass superior to Duodenal Mobilization Ch.24: In patients with Renovascular hypertension is there a role for open or endovascular revascularization compared to medical management? Ch.25: Does endovascular repair reduce the risk of rupture compared to open repair in splanchnic artery aneurysms? Section 4: Cerebrovascular Disease Ch.26: In patients with asymptomatic carotid artery stenosis does current best medical management reduce the risk of stroke compared to intervention (endarterectomy or stent)? Ch.27: In patients with symptomatic carotid artery stenosis is endarterectomy safer than carotid stenting? Ch.28: In Patients Undergoing Carotid Endarterectomy, is the Eversion Technique Superior to a Patch Technique to Reduce Restenosis? Ch.29: In patients with a stroke attributable to a carotid artery stenosis, does waiting to operate reduce the risk of complications? Ch.30: In patients with a peri-procedural cerebral thromboembolism, Does Neurovascular rescue improve Clinical Outcome? Ch.31: In patients with extra-cranial carotid artery aneurysms, does an endovascular approach improve clinical outcomes compared to open repair? Ch.32: In Patients with Carotid Artery Dissection, is Stenting Superior to Open Repair to Improve Clinical Outcomes? Ch.33: In patients with cervico-thoracic vascular injuries is endovascular repair superior in long-term durability when compared to open repair? Section 5: Venous and Arteriovenous Disease Ch.34: In Patients with Iliofemoral Deep Vein Thrombosis Does Clot Removal Improve Functional Outcome when Compared to Traditional Anticoagulation? Ch.35: In morbidly obese patients undergoing major abdominal operative procedures, does inferior vena cava filter placement prevent massive PE? Ch.36: In patients with chronic venous stenosis, does placement of a stent improve patency compared to recurrent angioplasty? Ch.37: In Patients with Chronic Venous Ulcer is the Unna Boot Still the Best Approach to Wound Care Ch.38: In Patients with Threatened or Occluded Access Grafts, Is it Better to Salvage the Graft, or Create a New Site? Ch.39: In patients with new arteriovenous fistulas, are there effective strategies to enhance AVF maturation and durability beyond waiting? Section 6: Perio-operative Management Ch.40: In patients with cardiovascular disease, do statins alone, or in combination with other medications improve mortality?Ch.41: In patients who have undergone a lower extremity bypass for PAD, does dual anti-platelet therapy improve outcomes?Ch.42: In patients undergoing vascular surgery, does preoperative coronary revascularization reduce the risk of myocardial infarction and death?

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Book SynopsisThis book presents up to date debates and issues in the world of breast MRI with a very practical focus on how to incorporate current understanding of breast MRI into clinical practice. The book is divided into three key sections, all of which have critical impact for the breast imager: Techniques introduces the reader to the parameters of breast MRI from standard sequences to up-to-date cutting edge techniques. Indications provides a careful review of the accepted indications for breast MRI from High Risk Screening to use of breast MRI, in the context of neoadjuvant chemotherapy with a detailed analysis of the evidence-based support for these indications and a careful look at controversies and debates within the field. MRI Findings, Interpretation, and Management takes on the topics of how to interpret and manage specific MRI findings from benign to malignant disease with a focus on radiologic-pathologic correlation. The section also incorporates a focus on key management dilemmas, including appropriate follow-up intervals for benign findings on MRI and management of probably benign lesions assessed as a Breast Imaging Reporting and Dictating System (BI-RADS)-3 category on MRI.Trade Review“This book is a comprehensive overview of the now well-established technique of breast MRI in the assessment of breast disease. … This book is most likely to be of interest to radiologists in sub-specialty training in breast imaging, but would also be of interest as a reference text to consultant radiologists established in reporting breast MRI with a moderate level of experience. … The book is compact and well laid out.” (Mamatha Reddy, RAD Magazine, June, 2018)Table of ContentsSection 1. Techniques.- 1. Breast MRI Technique.- 2. Breast MRI: Standing Terminologies and Reporting.- Section 2. Indications.- 3. MRI and Screening.- 4. MRI and Preoperative Staging in Women Newly Diagnosed with Breast Cancer.- 5. Magnetic Resonance Imaging and Noeadjuvent Chemotherapy.- 6. Breast MRI and Implants.- 7. Problem Solving Breast MRI for Mammographic, Sonographic, or Clinical Findings.- 8. Post-Operative findings/recurrent disease.- Section 3. MRI Findings, Interpretation and Management.- 9. In Situ Disease on Breast MRI.- 10. MRI appearance of Invasive Breast Cancer.- 11. Targeted Ultrasound after MRI.- 12. Breast Biopsy and Breast MRI Wire Localization.- 13. Breast MRI and the Benign Breast Biopsy.- 14. BI-RADS 3 Lesions on MRI.- 15. Multiparametric Imaging: Cutting-Edge Sequences and Techniques including Diffusion-Weighted Imaging, Magnetic Resonance Spectroscopy, and PET/CT or PET/MRI.- 16. Abbreviated Breast MRI.- 17. Personalized Medicine, Biomarkers of Risk and Breast MRI.

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Book SynopsisOf all the techniques used to treat non melanoma skin cancer, the highest cure rates belong to the Mohs surgical procedure. Critical to this technique is optimal preparation and interpretation of frozen sections. The second edition of this highly successful atlas details both common and uncommon cutaneous neoplasms that can serve as a source of reference for established practitioners and a review for those in training. It includes new frozen section specimens, the most current diagnostic guidelines, and discussion of the advancements in tissue staining. There is also an additional chapter with self-study tools, where readers can test their knowledge using various images with a multiple choice answer format, followed by a discussion of the correct answer. With high resolution figures, the Atlas of Mohs and Frozen Section Cutaneous Pathology, Second Edition is the premier text on the topic, serving as a highly practical guide to microscopic analysis, diagnosis, and discrimination of common and problematic cutaneous neoplasms. Highlights of the Atlas include diagnosis of basic and routine dermatologic entities, diagnosis and distinction of rare and/or deadly neoplasms such as dermatofibrosarcoma protuberans and merkel cell carcinoma, a troubleshooting guide dealing with quality control of the frozen section technique, and discussion of techniques including immunohistochemistry. Comprehensive and presented in full color, the Atlas of Mohs and Frozen Section Cutaneous Pathology, Second Edition is an indispensable reference for anyone involved with the Mohs procedure, including dermatologic surgeons, Mohs cutaneous surgeons, as well as pathologists and dermatopathologists who perform frozen section analysis of cutaneous specimens.Table of ContentsContentsSection I: Introduction1 Mohs and Frozen Section OverviewMichael B. Morgan, Terri Bowland2 Quality Assurance Dennis H. Nguyen, Daniel M. Siegel, Deborah Zell, Richard Spallone, Michael B. MorganSection II: Tumors of the Epidermis/Adnexae3 Histology with Regional and Ethnic Variation Michael B. Morgan, John R. Hamill, Jr.4 Benign Epidermal Tumors Michael B. Morgan5 Pseudotumors Martin Dunn, Michael B. Morgan6 Squamous Cell Carcinoma: Variants and Challenges Michael B. Morgan7 Basal Cell Carcinoma: Variants and Challenges Michael B. Morgan8 Adnexal Neoplasms Michael B. Morgan9 Malignant Adnexal Neoplasms Ryan S. Jawitz, Jack C. Jawitz, Michael B. Morgan10 Merkel Cell Carcinoma Michael B. Morgan11 Sebaceous Tumors Michael B. Morgan12 Paget’s Disease Michael B. Morgan13 Melanocyte Pathology Michael B. MorganSection III: Tumors of the Dermis14 Benign Mesenchymal Tumors Michael B. Morgan15 The Sarcomas Aaron M. Bruce, James M. Spencer16 Lymphoid Pathology John R. Hamill Jr., Michael B. MorganSection IV: Special Topics17 Perineural Pathology Martin Dunn, Michael B. Morgan18 Cytopathology of Cutaneous Tumors Kenneth B. Calder, Rahel Mathew, Michael B. Morgan19 Immunohistochemistry Applications Basil S. Cherpelis, L. Frank Glass, John R. Hamill Jr., Neil Alan Fenske20 Histotechnique and Staining Troubleshooting John R. Hamill Jr., Stephen SpencerSection V: Mohs Clinicopathologic Self-Test Series 21 A Painful Perineural Infiltrate Rebecca S. Thornhill, Tyler Scott22 A Painful Subcutaneous Nodule Rebecca S. Thornhill, Nicole Asher23 Basaloid LesionTyler Scott, Nicole Asher 24 Rapidly Growing Hemorrhagic PapuleRebecca S. Thornhill, Nicole Asher 25 Aggressive Spindle Cell NeoplasmRebecca S. Thornhill, Tyler Scott 26 Eyelid Tumor Nicole Asher, Tyler Scott27 Non-melanoma Skin Cancer with Anemia Rebecca S. Thornhill, Tyler Scott28 Follicular Neoplasm Tyler Scott, Nicole Asher29 Hemorrhagic Papule in a Patient with Lip Carcinoma Rebecca S. Thornhill, Tyler Scott30 Blue Ball in the DermisRebecca S. Thornhill, Nicole Asher

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Book SynopsisFollowing on the favorable reception of the first edition, the authors have thoroughly revised and updated the second edition of this resourceful clinical handbook. The book has been well received internationally by a wide audience of clinicians, including general dentists, oral surgeons, otolaryngologists, primary care physicians, nurse practitioners, dental hygienists, physician assistants, and dermatologists, and sales have been strong among students and post-graduate residents training in medical, dental, and allied health fields, supporting the versatility of this work and serving as testimony to its value in both the academic and private practice arenas. Several key updates and improvements have been made to the second edition. All informational content has been updated to ensure accuracy and relevance, particularly in the rapidly evolving fields of oncology and pharmacology. A new chapter has been added entitled “Oral Sequelae of Cancer and Cancer Therapy” which better organizes and consolidates previous content while expanding on topics such as targeted therapies and hematopoietic stem cell transplantation. Additional clinical images have been included throughout the book so that the full clinical spectrum of any given condition is well-represented. Furthermore, the print quality, as well as the positioning and layout of the clinical images has been improved for optimal utility. Lastly, the summary boxes that follow each condition have been reconfigured with color-coded icons for improved definition, ease of use and cross-referencing. Clinical Oral Medicine and Pathology, Second Edition will continue to serve as an authoritative contemporary resource for clinicians seeking guidance in the diagnosis and management of oral diseases.Trade Review“­The book is well structured with good flow from one chapter to the next. Each chapter is well laid-out with clear headings and illustrated text to help with diagnosis and management of oral medicine-related conditions. Concise descriptions of each condition provide background information and treatment recommendations with useful summary tables for quick reference. … this would be a useful resource for any healthcare professional seeing patients with oral disease.” (Anne M. Hegarty, British Journal of Hospital Medicine, Vol. 78 (1), January, 2017)Table of ContentsTable of Contents Chapter 1 Normal Anatomy Chapter 2 Variants of Normal and Common Benign Conditions Chapter 3 Diagnostic Tests and Studies Chapter 4 White Lesions Chapter 5 Immune-Mediated and Allergic Conditions Chapter 6 Pigmented Lesions Chapter 7 Oral Infections Chapter 8 Salivary Gland Disease Chapter 9 Oral Cancer Chapter 10 Orofacial Pain Conditions Chapter 11 Oral Manifestations of Systemic Disease Chapter 12 Oral Sequelae of Cancer Therapy Chapter 13 Prescribing Guidelines for Commonly Used Medicationsp>

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Book SynopsisThe lifestyles and socio-economic status that are prevalent in regions of the world with limited resources form the background for the unique features of neoplastic diseases in these areas, where the majority of the world population lives. The predominance of the world’s retroviral burden of in these areas further compounds the nature and challenges of the cancer there. Much of the international cancer literature covers the nature and challenges of the disease as seen in high-income regions of the world, thereby giving a skewed view of the global cancer challenges. As the low- and middle-income regions of the world transition from communicable to non communicable disease patterns, there is a need for a corresponding paradigm shift, with increased emphasis on what the world needs to know about non communicable diseases, including cancer, where the disease is hitherto poorly documented. The main goal of the proposed book is to contribute to this outcomes.Table of ContentsPart IV: Future Perspectives Chapter 10 – Strategies for progress Abstract Section 10.1.0: The role of international partnership in the development of global health systems Section 10.1.1: Models of humanitarian global outreach in health care Section 10.1.2: The concept of “convergence” and the future of health care research Section 10.1.3.0: The concept of global health Section 10.1.3.1: Models of global health partnership in cancer control Section 10.1.3.2: The tiered resource stratification framework of the Breast Health Global Initiative (BHGI) Network Section 10.1.3.3: ASCO’s resource-stratified guidelines for the management of invasive cervical cancer Section 10.1.3.4: NCCN framework for resource stratification for invasive cervical cancer Section 10.1.3.5: Resource-stratified approaches in the primary prevention of cervical cancer Section 10.1.3.5.1 ASCO resource-stratified guideline for the primary prevention of cervical cancer Section 10.1.3.6: Resource-stratified approaches in the secondary prevention of cervical cancer Section 10.1.3.4.1: Selected Global Health Activities for promoting cancer control/Health Volunteers Overseas (HVO) Section 10.1.3.4.2 Global Curriculum and Mentoring Program Section 10.1.3.4.3: Global Curriculum and Mentoring Program/International Development and Education Award Section 10.1.3.4.4: Proposal for recognizing global oncology as an academic field Section 10.2: Overcoming barriers to progress in the control of cancer and retroviral diseases, including HIV/AIDS Section 10.2.1: Prioritizing strategies for universal health coverage Section 10.2.1.1: mHealth Strategies for Universal Health Coverage Section 10.2.1.2: Community Health Insurance Coverage as a strategy for Universal Health Care Section 10.2.1.3: Innovation in provider training as a strategy in UHC Section 10.2.2: The role of politics in attainment of Universal Health Coverage Section 10.2.3: The role of science and engineering in human welfare Section 10.2.3.1: The role of science Section 10.2.3.1.1: Science advocacy Section 10.2.3.1.2: Science education in low- and middle-income countries Section 10.2.3.1.3 Examples of the transforming effect of science in LMICs Section 10.2.3.1.3.1 Impact of science on the emergence of South Korea Section 10.2.3.1.3.2: Impact of science on Middle-Eastern cooperation Section 10.2.3.1.3.3: Impact of the US-Cuba scientific diplomacy Section 10.2.3.1.3.4: Boosting science in Singapore Section 10.2.3.1.3.5: India boosts its ambitious space program Section 10.2.3.2: Transforming the practice of engineering to meet global health needs Section 10.2.3.3 Models in innovation with potentials for cancer and HIV/AIDS control in LMICs Section 10.2.3.3.1: Affordable, weather durable x-ray machine Section 10.2.3.3.2: Affordable cancer immunotherapy in Cuba Section 10.2.3.3.3: The smart village for rural electrification Section 10.2.3.3.4: HIV/AIDS control in China Section 10.3: The future of control of cancer and retroviral diseases Page 1055: Section 10.3.1: From the National Cancer Act to the 21st Century Cures Act Page 1059: Section 10.3.2: Advances in lung cancer prevention Page 1062: Section 10.3.3: Ending the HIV/AIDS pandemic Page 1063: Section 10.3.4: Finding a cure for AIDS – a possible convergence of cancer and HIV/AIDS researchIndex

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Book SynopsisThis text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.Table of ContentsPart I: Perspectives on Cancer Pain Medicine.- Perspectives on Interventional Cancer Pain Management.- The Practice of Cancer Pain: A Case Series.- Part II: Cancer Pain Syndromes.- Pathophysiology of Cancer Cancer Pain.- Chemotherapy.- Post-Surgical Pain Syndromes.- Radiation-Induced Pain Syndromes.- Part III: Paradigms in Cancer Pain Syndromes.- General Pain Management Concepts.- Head and Neck.- Breast Cancer Pain: A Review of Pathology and Interventional Techniques.- Thoracic Cancer Pain.- Gastrointestinal Cancer Pain.- Genitourinary Cancer Pain Syndromes.- Pediatrics.- Pain in Hematologic Malignancies.- Dermatologic Cancer Pain Syndromes.- Part IV: Percutaneous Pain Techniques and Anatomy.- Ablative Techniques.- Sympathetic Nervous System Blocks for the Treatment of Cancer Pain.- Peripheral Nerve Blocks. Cranial Nerve Targets.- Vertebroplasty, Kyphoplastly, and Sacroplasty.- Treatment Considerations for Cancer Pain Syndromes.- Part V: Surgical Techniques Electrical Modulation.- Intracranial Neuroablation.- Spinal Neuroablation for Cancer Pain.- Radiosurgery.- Deep Brain Stimulation and Motor Cortical Stimulation for Malignant Pain.- Spinal Cord Stimulation and Oncologic Pain Management.- Peripheral Nerve Stimulation for the Treatment of Cancer Pain.- Transcutaneous Electrical Nerve Stimulation for Cancer Pain.- Part VI: Intrathecal Drug Delivery.- Indications for Intrathecal Pump Therapy.- Intrathecal Drug Delivery System Trialing for Cancer Pain Management.- Pump Implantation Technique.- Medications in Intrathecal Pumps.- Compounding Drugs for Intrathecal Use.-Part VII: Interventional Oncology.- Image Guidance and Planning.- Ablative Techniques for Painful Metastasis (PFA, Cryo, Chemical, HIFU).- Introduction to Radiation Therapy.- Palliative Radiation Therapy.- External Beam Radiotherapy in the Treatment of Painful Bone Mestastases.- Non-Opioid Intravenous Infusions for Management of Cancer Associated Pain.- Part VIII: Interventional Physiatry.- Cancer Rehabilitation.- Neuromuscular Medicine-Cancer Pain.- Cancer-Related Pelvic Pain.- Exercise Therapy and Fatigue Management.- Physical Therapy.- Occupational Therapy.- Cancer Pain and Physical Modalities.- Osteopathic Treatment for Cancer-Related Pain.- Rehabilitation Bracing as a Conservative Treatment Option.- Part IX: Complementary and Psycho-Behavioral Therapies.- Psycho-social Assessment and Treatment for Patients with Cancer Pain.- Relaxation Techniques and Biofeedback for Cancer Pain Management.- Mood and Anxiety in Cancer Pain.- Acupuncture and Cancer Pain.- Creative Therapies and Mind-Body Health Systems.- Botanical Treatments in Cancer Pain Management.- Integrative Therapies for Pain Modulation.

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Book SynopsisDie Herausgeber, anerkannte Spezialisten und aktiv in der Interdisziplinären Arbeitsgruppe Weichteilsarkome (IAWS) der Deutschen Krebsgesellschaft, stehen für fundiertes Fachwissen. Das Werk zeichnet sich durch eine praxisorientierte und übersichtliche Darstellung aller bei Weichteilsarkomen klinisch relevanten Themen aus. Ausführlich wird auf Diagnostik, Klassifikation, Stadieneinteilung wie auch molekulare und genetische Aspekte als Grundlage therapeutischer Entscheidungen eingegangen. Ein weiteres zentrales Thema ist die interdisziplinäre Behandlung (Chirurgie, Strahlentherapie, medikamentöse Therapie) und deren Sequenz für die zahlreichen, unterschiedlichen Entitäten von Weichteilsarkomen. Auch spezielle Therapieverfahren, wie Extremitätenperfusion und Hyperthermie werden besprochen. Ärzte in Klinik und Praxis erhalten mit diesem Buch kompetente Unterstützung für die optimale Betreuung von Patienten mit Weichteilsarkomen.Table of ContentsI. Epidemiologie II. Diagnostik III. Chirurgische Therapie IV. Strahlentherapie V. Medikamentöse Therapie VI. Spezifische Therapieverfahren VII. Nachsorge, Rehabilitation und PsychoonkologieAnhang

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Book SynopsisThis book is an ideal manual on the use of modern ultrasound in the diagnosis of breast pathology. It provides a comprehensive overview of current ultrasound techniques and explains the advantages and pitfalls of various ultrasound imaging modalities. Detailed attention is devoted to breast carcinoma, with guidance on differential diagnosis and presentation of pre- and postoperative ultrasound appearances. The most important benign breast diseases are also described and illustrated. Age-related features, including those seen in children and adolescents, are carefully analyzed, and an individual chapter is devoted to breast abnormalities in men. All aspects of lymph node appearances are reviewed in detail, with a special focus on the role of ultrasound in the evaluation of lymph node status. Ultrasound-guided breast interventions and imaging of breast implants are discussed in depth. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.​Table of ContentsDiagnosis of Breast Cancer.- Technique of Breast Ultrasound.- Ultrasound of the Normal Breast .- Ultrasound Diagnosis of Breast Cancer.- Differential Diagnosis of Breast Diseases.- Breast Ultrasound in Children and Adolescents.- Breast Pathology in Men.- Ultrasound Examination of Regional Lymph Nodes.- Ultrasound Examination after Breast Surgery.- Recurrent Breast Cancer.- Ultrasound Imaging in Patients with Breast Implants.- Ultrasound-Guided Breast Intervention.- Conclusion.

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Book SynopsisUse of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors’ experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea and esophagus and miscellaneous items including the role of robotic surgery.Trade ReviewFrom the book reviews:“This book offers expert instruction on thoracic surgery through a cervical approach, covering current applications thoroughly and discussing future uses. … The book is written for practitioners and trainees in thoracic surgery. … This is a very useful book for practitioners of thoracic surgery interested in performing procedures through a cervical incision. It offers a detailed discussion of a topic often only covered in a textbook chapter. It will be a good addition to any reading on thoracic surgery.” (Michael Bates, Doody's Book Reviews, December, 2014)Table of ContentsDIAGNOSTIC AND STAGING SURGICAL ENDOSCOPIES.- Mediastinoscopy.- Extended Cervical Mediastinoscopy.- Remediastinoscopy.- Mediastino-Thoracoscopy.- Cervical Incision Thoracic Endoscopic Surgery (CITES).- Mediastinal Ultrasonography (MUS) as a Surgical Adjuvant In Lung Cancer Staging.- Video-Assisted Mediastinoscopic Lymphadenectomy (VAMLA).- Transcervical Extended Mediastinal Lymphadenectomy (TEMLA): The Standard Procedure And Its Variations.- THYMUS AND MEDIASTINUM.- Thymectomy Through Cervicotomy.- Transcervical Extended Thymectomy With Bilateral Opening Of The Mediastinal Pleura.- Transcervical Thymectomy With Bilateral Video-Assisted Thoracoscopic Surgery (VATS).- Rethymectomy.- Transcervical Resection Of Mediastinal Metastatic Nodes And Mediastinal Tumors.- Miscellaneous Indications: Mediastinitis, Cysts, Etc.- LUNGS AND BRONCHI.- Lobectomy.- Closure Of Postpneumonectomy Bronchopleural Fistula.- Closure Of The Main Bronchus Prior To The Definitive Pneumonectomy.- TRACHEA AND OESOPHAGUS.- Tracheal Resection.- Oesophageal Procedures.- MISCELLANY.- Thoracic Outlet Syndrome –Supraclavicular Approach.- Robotics. ​

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Book SynopsisManfred Georg Krukemeyer beschreibt zunächst das Magnetic Drug Targeting, unter dem man die zielgerichtete Arzneimittelapplikation – z. B. das Schleusen eines Zytostatikums – versteht und das eine Optimierung des lokaltherapeutischen Effekts erreichen soll. So erreicht der Autor am Ort des Tumors eine hohe Konzentration des Zytostatikums. Die Partikeln müssen groß genug sein, um von einem Magnetfeld angezogen zu werden, und wandern so in den Tumor, um dort ihren Wirkstoff freizusetzen. Ziel der Hypothese einer Studiengruppe des Autors war es, in einem wissenschaftlichen Experiment darzulegen, dass in diesem Fall Zytostatika an Eisenpartikeln gekoppelt [Fe3O4], in einen Tumor geschleust werden können. Das zielgerichtete Schleusen von Medikamenten – Magnetic Drug Targeting – führt zu einem schnelleren Erreichen des Wirkstoffs am Zielort bei einer verminderten Menge an Wirksubstanzen. Von daher ist das Magnetic Drug Targeting auch unter ökonomischen Aspekten interessant.Table of ContentsSarkome und deren Pathologie.- Magnetic Drug Targeting.- Tierversuche und Patientenuntersuchung, Tumortherapie beim Menschen.

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Book SynopsisEine Krebsdiagnose wirft die meisten Menschen aus der Bahn und bedeutet einen tiefen und bedrohlichen Einschnitt in ihr eigenes Leben, aber auch dasjenige ihrer Angehörigen. Die Erkenntnis, dass das Leben endlich und prekär ist, kann existenzielle Ängste, tiefe Trauer und Fragen nach dem Sinn auslösen, geht es ja letztlich um die Fragen nach Sterben und Tod. Wie können involvierte Fachpersonen mit diesen letzten Fragen der „conditio humana“ umgehen, wie können sie, trotz eigener Betroffenheit, angesichts dieser existenziellen Herausforderungen tragend und hilfreich sein? Diesen Fragen geht die vorliegende Publikation mit theoretischen Inputs sowie praktischen Vorschlägen für den Aufbau einer existenziellen Grundhaltung erfolgreich nach.Die Autorin Barbara Leu ist Psychotherapeutin (systemisch und existenzielle Ausrichtung) und Psychoonkologin am Kantonsspital Aarau, Schweiz. Daneben arbeitet sie als Psychotherapeutin in einer psychiatrisch/psychologischen Gemeinschaftspraxis in Zürich, Schweiz. Table of ContentsArten von Angst und Verlust.- Sinn im logotherapeutischen Verständnis und in der personalen Existenzanalyse.- Handhabung für die Praxis im Umgang mit Angst, Trauer und Sinn bei einer schweren Erkrankung.

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Book SynopsisSurvivin ist in nahezu allen malignen Tumorerkrankungen überexprimiert und aufgrund seiner dualen Rolle als Apoptose-Inhibitor und Zellzyklus-Regulator an zwei entscheidenden Prozessen der Onkogenese beteiligt. Für die Ausübung beider biologischer Funktionen ist die Interaktion von seinem Kernexportsignal mit dem Exportrezeptor Crm1 essentiell, weshalb die gezielte Inhibition dieser Interaktion einen guten Angriffspunkt für die Krebstherapie darstellt. Lisa Oelschläger analysiert die Effekte supramolekularer Liganden auf die Funktion von Survivin, die mit ihrer hohen Affinität gegenüber oberflächenexponierten Lysin- und Arginin-Seitenketten einen vielversprechenden neuen Ansatz zur gezielten Inhibition der Survivin-Crm1-Interaktion darstellen. Table of ContentsMolekulare Pinzetten – Lysin- und Arginin-spezifische supramolekulare Liganden.- Analyse der Bildung des Exportkomplexes in vitro.- Effekte der supramolekularen Liganden auf die Bildung des Exportkomplexes.- Untersuchung der zellulären Exportaktivität von Survivin.

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Book SynopsisDie Autorin erkrankte in ihrem Leben zwei Mal an Leukämie. Yoga half ihr bei der Bewältigung der lebensbedrohenden Krankheit und auf ihrem Weg zurück in ein erfülltes kraftvolles Leben. Ihre Erfahrungen gepaart mit ihrem Wissen als ganzheitliche Ärztin mit eigener Yogapraxis gibt sie nun in diesem Buch weiter. Einfach und anschaulich beschreibt sie welche Strategien zur Bewältigung der bei Krebs häufig auftretenden körperlichen und mentalen Lebenskrise helfen können und wie sich die Geisteshaltung und Lebensführung durch Yoga positiv auf die Krankheit auswirkt. Herzstück des Buches sind die Yoga-Übungsanleitungen in Wort und Bild. In einfachen, gut nachvollziehbaren Anleitungen stellt sie Übungen vor, ihre therapeutische Wirkung und Abwandlungen für mögliche körperliche Einschränkungen. Aus Aufwärmübungen, Körperhaltungen (Asanas) und Atemübungen (Pranayama) kann ein individuelles, vollständiges Übungsprogramm zusammengestellt werden. Das Buch richtet sich an Betroffene, sowie an Yogalehrer, Trainer und Physiotherapeuten, aber auch an Ärzte und Pflegekräfte in der Onkologie.Table of Contents1. Wie die Diagnose Krebs Menschen verändert.- 2. Zurück ins Leben - gibt es ein normales Leben danach?.- 3. Onkorehabilitation mit Bewegung.- 4. Yoga für "Surviver" - Erfolge von Yogatherapie in klinischen Studien.- 5. Yoga - indische Gymnastik?.- 6. Yoga Übungsanleitungen. 7.- Den Yogaweg leben mit Ayurveda.- 8. Serviceteil.

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Book SynopsisLiquid-based cytology preparations are currently the standard of care for gynecological cytology, and are being increasingly used for non-gynecological cytology. Diagnostic Liquid-Based Cytology serves as a handy guide to diagnostic cytopathology on liquid-based preparations. The authors, renowned experts in the field, provide clear, concise, and practical diagnostic guidance.This handbook equips you to achieve accurate diagnosis of most commonly and uncommonly encountered diseases in exfoliative and aspirated tissue samples from various sites. The key cytopathological features of various diseases are described. The book is lavishly illustrated with dozens of color images that depict the full range of common and rare conditions.Diagnostic Liquid-Based Cytology offers highly practical guidance and information needed to solve common diagnostic challenges in liquid-based cytology preparations. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is an excellent resource not only for practicing pathologists as well as for pathologists-in-training, and will be the perfect practical resource for daily reference in the cytopathology laboratory.Trade Review“This is a handbook of cytopathology on liquid-based specimens. … The intended audience is practitioners of cytopathology, and the book would be useful to cytopathologists or cytotechnologists in training or in practice, and pathology residents and cytopathology fellows. It might be of interest to other clinical specialties where cytopathology has or is emerging as a useful noninvasive diagnostic tool. … Get it -- you'll use it often and you'll learn something new each time.” (Valerie Ng, Doody's Book Reviews, June, 2017)Table of ContentsLiquid-Based Specimen Collection, Preparation and Morphology.- Gynecologic Cytology.- Urinary Tract Cytology.- Gastrointestinal Tract Cytology.- Body Cavity Fluids.- Respiratory Exfoliative Cytology.- Fine Needle Aspiration of Thyroid Gland.- Fine Needle Aspiration of Salivary Glands.- Fine Needle Aspiration of Lung.- Cytologic Diagnosis of Lymphoproliferative Disorders by Morphology and Ancillary Techniques.- Fine Needle Aspiration of Pancreas & Liver.- Fine Needle Aspiration of Breast.

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Book SynopsisDieses kompakte und praxisrelevante Standardwerk richtet sich alle Ärzte in Klinik und Praxis, die Patientinnen mit bösartigen Tumoren des Genitales und der Mamma behandeln. Die 5. Auflage wurde komplett aktualisiert und auf der Basis internationaler Leitlinien und Empfehlungen auf den neuesten Wissensstand gebracht. Sie finden einfach umsetzbare Handlungsanweisungen zum diagnostischen und therapeutischen Vorgehen und profitieren in bewährter Weise von der Expertise und dem reichen klinischen Erfahrungsschatz der Herausgeber und Autoren.Table of Contents

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Book SynopsisBildgebung bei Erkrankungen des Lymphgefäßsystems - Das Wichtigste für alle Ärztinnen und ÄrzteErkrankungen des Lymphgefäßsystems sind häufig, werden jedoch oft nicht erkannt oder in Ihrer Tragweite unterschätzt. Kenntnisse über die diagnostischen Möglichkeiten mittels bildgebender Verfahren sind selbst bei lymphologisch orientierten, aber auch in der Tumornachsorge tätigen Ärztinnen und Ärzten oft nur eingeschränkt vorhanden.Umfassend, praxisbezogen und anwendungsorientiert stellen die Autoren die bildgebenden diagnostischen Verfahren des Lymphgefäßsystems, deren technische Durchführung, Möglichkeiten und Grenzen dar. Das Buch wendet sich an Fachärztinnen und Ärzte sowie Ärztinnen und Ärzte in Ausbildung, zu deren Fachrichtung Erkrankungen des Lymphgefäßsystems gehören, also Allgemeinmediziner, Angiologen, Chirurgen, Dermatologen, Internisten, Lymphologen, Phlebologen. Aus dem Inhalt: Funktionelle Anatomie des Lymphgefäßsystems Lymphszintigraphie/Funktionslymphszintigraphie Magnetresonanz-Lymphangiographie Indirekte Lymphangiographie und Direkte Lymphographie Sonographische Diagnostik der Lymphknoten und Lymphgefäße Sonographische Befunde bei Ödemen und Lymphödemen und anderen interstitiellen Flüssigkeitseinlagerungen Zystische lymphatische Malformation (LM) - Diagnose und Therapie Indocyaningrün (ICG)-Lymphographie in der Lymphchirurgie Nuklearmedizinische Wächterlymphknoten-Diagnostik Positronenemissionscomputertomografie (PET) - Detektion pathologischer Lymphknoten Fluoreszenz-Mikrolymphographie - eine wichtige Methode zur Frühdiagnose des Lymphödems Table of Contents1. Funktionelle Anatomie des Lymphgefäßsystems.- 2. Genetik des Lymphgefäßsystems.- 3. Physiologie und Pathophysiologie des Lymphgefäßsystems.- 4. Grundlegende klinische Diagnostik und Differentialdiagnostik - Basis der bildgebenden Diagnostik des Lymphgefäßsystems.- 5. Lymphszintigraphie/Funktionslymphszintigraphie.- 6. Magnetresonanz-Lymphangiographie.- 7. Indirekte Lymphangiographie.- 8. Hintergründe unterschiedlicher Injektionstechniken bei der Funktionslymphszintigraphie, statischen Lymphszintigraphie und Sentinel Lymph Node (SLN)-Markierung, indirekten Lymphangiographie und Magnetresonanz (MR)-Lymphangiographie, Indocyaningrün (ICG)-Lymphangiographie sowie der direkten Lymphographie.- 9. Sonographische Diagnostik der Lymphknoten und Lymphgefäße.- 10. Sonographische befunde bei Ödemen und Lymphödemen und anderen interstitiellen Flüssigkeitseinlagerungen.- 11. Direkte Lymphographie mit Intranodaler Lymphangiographie und Lymphgefäßinterventionen.- 12. Zystische lymphatische Malformation (LM) - Diagnose und Therapie.- 13. Indocyaningrün (ICG)-Lymphographie in der Lymphchirurgie.- 14. Nuklearmedizinische Wächterlymphknoten-Diagnostik.- 15. Positronenemissionscomputertomografie (PET) - Detektion pathologischer Lymphknoten mit Hilfe der Positronenemissionscomputertomographie.- 16. Fluoreszenz-Mikrolymphographie - eine wichtige Methode zur Frühdiagnose des Lymphödems.-

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Book SynopsisMalignome des Kopf-Halsbereichs sind eine heterogene Gruppe bösartiger Tumoren, deren Diagnostik und Therapie ein inter- und multidisziplinäres Konzept erfordern. Ein Team unter anderem bestehend aus Mund-, Kiefer-, Gesichtschirurgen, Hals-Nasen-Ohren-Ärzten, Dermatologen, Onkologen, Strahlentherapeuten, Radiologen, Nuklearmedizinern, Pathologen, Zahnärzten, onkologischen Pflegefachkräften, Physiotherapeuten, Ernährungsberatern und Psychologen sind für die krankheitsgerechte Betreuung der Patienten zuständig. Table of Contents

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Book SynopsisCirca jeder 3. Patient in der Urologie ist ein Tumorpatient. In der Uroonkologie sind es meist ältere, an Prostatakrebs erkrankte Männer, die nicht gelernt haben, über Ihre Gefühle zu sprechen. Aber auch jüngere Männer leiden, besonders unter begleitenden sexuellen Funktionsstörungen.In diesem Praxisbuch werden die Grundlagen der psychosozialen Uroonkologie erläutert wie auch die Diagnostik und Therapie. Es schildert die Besonderheiten der männlichen Patientengruppe, stellt die wichtigsten Tumorentitäten kurz dar und richtet den Blick auch auf psychische Komorbiditäten. Intensiv werden Patientenängste, z. B. Progredienzangst, Sexualität, Tod thematisiert und Sie erhalten zahlreiche Tipps, wie Sie ein Patientengespräch führen und Hilfen anbieten können. Hinweise und Übersichten für den Arbeitsalltag zur Diagnostik und Therapie und Praxistipps zum Umgang mit der meist älteren, männlichen Patientengruppe erleichtern die Gesprächsführung und erweitern das Hilfsangebot für den Patienten. Das Buch basiert auf der Fachexpertise eines renommierten Autorenteams und spiegelt den aktuellen Stand der Wissenschaft wider. Es erfolgen viele Verweise und Erläuterungen zur S3-Leitlinie „Psychoonkologische Diagnostik, Beratung und Behandlung von erwachsenen Krebspatienten“.Für Urologen, Onkologen, Psychotherapeuten und jeden Arzt, der urologische Tumorpatienten behandelt, und diesen wertvollen Baustein in der Krebstherapie professionell nutzt - für mehr Lebensqualität des Patienten. Trade Review“... Zu den Besonderheiten der Urologie schließt das vorgestellte Lehrbuch die bislang als deutlich wahrgenommene Lücke in der psychoonkologischen Literatur auf Fachbuch-Ebene. Den Herausgebern und neun weiteren Autoren ist es hervorragend gelungen, die psychosoziale Uroonkologie in allen relevanten Facetten darzustellen. Die komplexe Thematik wird auf 220 Seiten sehr übersichtlich unter Verwendung verständlicher Schemata und informativer Abbildungen kompetent, kompakt und interessant vermittelt — Lehrbuch und Nachschlagewerk gleichermaßen ...” (Dieter Jocham, in: Der Urologe, 1. April 2023) Table of ContentsGrundlagen der psychosozialen Uroonkologie.- Psychische Komorbiditäten.- Psychoonkologische Diagnostik.- Das bio-psychosoziale Konzept.- S3-Leitlinie.- Psychosoziale Belastung bei urolog. Tumorerkrankungen.- Psychosoziale Interventionen.- Behandlungsmethoden.- Krebs und Familie.- Krebs und Sexualität.- Krebs und Beruf.- Psychoonkologische Versorgungsstrukturen.

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Book SynopsisRenommierte Heidelberger Wissenschaftler haben in diesem Buch zusammengetragen, was heute über Krebserkrankungen und ihre Ursachen bekannt ist. Lediglich 5 bis 10% aller Krebserkrankungen werden durch vererbte Gendefekte verursacht. Epidemiologische und experimentelle Daten aus wissenschaftlichen Studien und Hochrechnungen zeigen, wie sehr das Erkrankungsrisiko durch die eigene moderne Lebensweise beeinflusst wird. Die Autoren haben sich zum Ziel gesetzt, diffusen Ängsten und gefährlichem Halbwissen wissenschaftlich valides Wissen entgegenzusetzen und diese Daten und Fakten verständlich und unterhaltsam zu präsentieren. Das Buch richtet sich an alle medizinisch Interessierten, Betroffene und Angehörige.Table of ContentsNeuigkeiten aus der Krebsforschung.- Ein beunruhigender Trend.- Das Immunsystem und Krebs.- Was uns HIV und Organspenden über den Krebs verraten.- Krebsfördernde Umwelteinflüsse und Erkrankungen.- Alter und Krebs.- Zucker, Fette und Übergewicht.- Bewegungsmangel als Krebsursache.- Ernährung und Darmkrebs.- Infektiöse Erreger in Rindfleisch und Kuhmilch?.- Stress und Krebs.- Entzündungshemmer, Vitamine und Antioxidantien.- Krebsprävention - Allheilmittel und Anti-Aging-Therapie.- Die Therapie der Zukunft.- Personalisierte Medizin: die richtige Therapie für den richtigen Patienten zur richtigen Zeit.- Ein Denkmal für die Maus.- Schlusswort.- Danksagung.

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Book SynopsisMedizinische Grundlagen.- Management und Qualitätssicherung.- Struktur, Versorgung und Akteure/Stakeholder.- Arzneimittelmarkt.- Studienarten und Analysemethoden.- Regulierung und Steuerung.- Versorgungsforschung.

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Book SynopsisHeute erfordert eine adäquate onkologische Therapie nicht nur tumorspezifisches Fachwissen, sondern auch spezifische Kenntnisse supportiver Maßnahmen, insbesondere über Prophylaxe und Behandlung relevanter Nebenwirkungen der onkologischen Therapien. Auch der Einsatz psychoonkologischer Methoden, ethische Fragen sowie Sinn und Zweck der Palliativmedizin und der Rehabilitation sind Themen, die alle in der Betreuung Krebskranker Tätigen beschäftigen. So unterschiedlich die Thematik der einzelnen Kapitel ist: das gemeinsame Ziel ist, die Lebensqualität Krebskranker in allen Stadien ihrer Erkrankung zu verbessern.

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Book SynopsisAdvances in CT have enabled us to detect small lung cancers, which has changed the lung cancer surgery from lobectomy to a lesser lobar resection such as a segmentectomy or wedge resection. While wedge resection is a simple procedure, it has a higher risk of local recurrence of cancer than a lobectomy. On the other hand, segmentectomy is a well known curative surgery for small lung cancers. However, it is difficult to perform accurately because of its anatomical complexity, which makes surgeons hesitant to use it. The book “Illustrated Anatomical Segmentectomy for Lung Cancer” provides readers a detailed explanation of segmentectomy with numerous easy-to-understand color illustrations showing the precise segmental anatomies for each pattern of the procedure. To better illustrate an accurate anatomical segmentectomy, the text shows details of anatomy during segmentectomy. This can involve up to 25 patterns, each of which is shown in roughly 10 illustrations.Trade ReviewFrom the reviews:“The purpose is to accurately describe segmental lung anatomy as it pertains to lung resections in the treatment of lung cancer. This worthy objective is achieved with a high level of detail and accuracy by the authors. The book is written for clinicians at all levels involved in the diagnosis and treatment of patients with lung cancer. … The stylized illustrations are descriptive and clear. … This is an excellent resource for the field of lung cancer and thoracic surgery.” (Michael Bates, Doody’s Book Reviews, July, 2013)Table of Contents

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Book Synopsis This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. Table of Contents1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy.- 2 immune composition of gastrointestinal tract of Gut.- 3 Immunomarkers for detection of GI malignancies.- 4 Immuno-therapeutics of gastrointestinal malignancies.- 5 Immune cell therapy against gastrointestinal tract cancers.- 6 Immune checkpoint inhibitors in gastrointestinal malignancies.- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers.- 8 Therapeutic Vaccines for Gastrointestinal Malignancies.- 9 Immuno-Oncology of Oesophageal Cancer.- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies.- 11 Immuno-oncology of colorectal cancer.- 12 Immune targets in colorectal cancer.- 13 Applications of computational biology in gastrointestinal malignancies.

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Book SynopsisThis atlas describes and illustrates in detail the surgical procedures employed in laparoscopic anatomical liver resection, according to tumor location. The surgical approach and techniques are explained for each type of laparoscopic liver resection based on the involved anatomical segment, section, and hemi-liver. Attention is also drawn to potential complications and the means of preventing and managing them. Beyond anatomical liver resection, guidance is provided on non-anatomical resections that do not pay regard to segmental, sectional, or lobar anatomy. The coverage is completed by the inclusion of useful information on instruments and energy devices as well as the basic skills required for laparoscopic liver resection. In presenting a clear practical approach to each laparoscopic anatomical major and minor resection, the Color Atlas of Laparoscopic Liver Resection will be an invaluable guide for trainees. In addition, it will equip more experienced surgeons with much useful information that will enable them to further improve their technique.Table of Contents1. Introduction.- 2. Instruments and energy devices for laparoscopic liver resection.- 3. Basic skills for laparoscopic liver resection.- 4. Anatomical liver resection.- 5. Non-anatomical liver resection.- 6. Others.

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Book SynopsisThis book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. Table of ContentsChapter 1. Obesity induced chronic low-level inflammation and cancers.- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers.- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation.- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer.- Chapter 6. Immune response and oxidative stress in obesity induced cancer.- Chapter 7. Role of gene polymorphism in obesity and cancer.- Chapter 8. Therapeutic role of green tea in obesity and cancer.- Chapter 9. Effect of dietary phytochemicals in obesity and cancer.- Chapter 10. Resveratrol as anti-obesity and anticancer agent.- Chapter 11. EGCG as anti-obesity and anticancer agent.- Chapter 12. miRNAs as therapeutic target in obesity and cancer.- Chapter 13. In silico updates on lead identification for obesity and cancer.- Chapter 14. In vivo models for obesity and obesity related carcinogenesis.- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases.- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.

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Book SynopsisThis comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy.Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.Table of ContentsPart I Current topics in Epidemiology and Examinations of Pancreatic Cancer and Cholangiocarcinoma 1 Risk Factors for Pancreatic Cancer and Cholangiocarcinoma 2 Detection strategies and examination of early pancreatic cancer 3 Biomarkers for Pancreatic Cancer and Cholangiocarcinoma 4 Recent advances of precision medicine in pancreatic cancer and and cholangiocarcinoma Part II Anti-cancer Treatments for Pancreatic Cancer 5 Chemotherapy for locally advanced and metastatic pancreatic cancer 6 Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer 7 Adjuvant Chemotherapy for Pancreatic Cancer 8 Conversion Surgery in Pancreatic Cancer 9 Radiotherapy for pancreatic cancer Part III Anti-cancer Treatments for Cholangiocarcinoma 10 Chemotherapy for Unresectable Cholangiocarcinoma 11 Adjuvant chemotherapy for cholangiocarcinoma 12 Neoadjuvant therapy and conversion surgery for cholangiocarcinoma 13 Radiotherapy for Cholangiocarcinoma Part IV New Treatment for Pancreatic Cancer and Cholangiocarcinoma 14 Precision medicine for pancreatic cancer and cholangiocarcinoma 15 Immunotherapy for pancreatic cancer and biliary tract cancer 16 Treatment approach for pancreatic ductal adenocarcinoma with peritoneal dissemination 17 Treatment strategies for frail and elderly patients with pancreatic cancer Part V Endoscopic Management of Pancreatic Cancer and Cholangiocarcinoma 18 Endoscopic diagnosis of pancreatic cancer and cholangiocarcinoma 19 Preoperative biliary drainage for pancreatic cancer and cholangiocarcinoma 20 ERCP for malignant biliary obstruction for unresectable pancreatic cancer and cholangiocarcinoma 21 Interventional EUS for pancreatic cancer and cholangiocarcinoma 22 Novel endoscopic focal therapy for pancreatic cancer and cholangiocarcinoma 23 Endoscopic management of gastrointestinal obstruction from pancreaticobiliary cancer 24 Development of Self-expandable Biliary Metal Stents for Pancreatic Cancer and Cholangiocarcinoma

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