Oncology Books
Springer Verlag, Singapore Hereditary Breast and Ovarian Cancer: Molecular
Book SynopsisThis highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.Table of Contents1 History, Advancements, and Future Strategies 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis 3 Genetic Testing 4 Variants of uncertain significances in hereditary breast and ovarian cancer 5 Genetic counseling in Hereditary Breast and Ovarian Cancer 6 Hereditary Breast Cancer 7 Hereditary Ovarian Cancer 8 Risk-Based Breast Cancer Screening 9 Chemoprevention for Breast Cancer 10 Chemoprevention for Ovarian Cancer 11 Risk-Reducing Mastectomy (RRM) 12 Risk-reducing salpingo-oophorectomy (RRSO) 13 Panel Testing 14 Germline Findings through Precision Oncology for Ovarian Cancer 15 Germline Findings from Genetic Testing for Breast Cancer 16 Hereditary Breast and Ovarian Cancer (HBOC) Database 17 Ethical Issues: Overview in Genomic analysis and Clinical Context 18 PARP Inhibitors-Mechanism of action 19 PARPi - Efficacy in Hereditary Breast Cancer 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer
£116.99
Springer Verlag, Singapore Cancer Diagnostics and Therapeutics: Current
Book SynopsisThis book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.Table of ContentsChapter 1_ introductory cancer biology. –Chapter 2_Cancer: Getting informed about the Basics. –Chapter 3_Tumour Biology: An Introduction. –Chapter 4_Role of Angiogenesis in Tumour–Chapter 5_Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis. –Chapter 6_MRI, CT, and PETSCAN: An Engineer’s Perspective. –Chapter 7_Diffusion, MRI, and Cancer Diagnosis: Physicists’ Outlook. –Chapter 8_Oncology: Radiation Oncologist’s View. –Chapter 9_Radiomics: Comprehensive and Advance Image Analysis based Radiological Investigations. –Chapter 10_Oncology: Biochemists’ Perspective. –Chapter 11_Oncology: Pathologist’s View. –Chapter 12_Surgical Oncology: An Overview. –Chapter 13_Medical Oncology in Cancer Treatment. - Chapter 14_Effects of Cancer Chemotherapy on Immune System. –Chapter 15_Side-effects of Cancer Chemotherapy. –Chapter 16_Telomerase and its Therapeutic Implication in Cancer. –Chapter 17_Pain Management in Oncology. –Chapter 18_Other Approaches in Cancer Research: Stem-cell Research, Translational Research, and Immuno-therapy. –Chapter 19_Cancer Cell Lines: It’s Implication in Therapeutics. –Chapter 20_ Genomics of Cancer. –Chapter 21_Diabetes and Cancer Link. –Chapter 22_Cancer Genomics and Diagnostics: Northeast Indian Scenario. –Chapter 23_Oncology Informatics, AI and Drug Discovery. –Chapter 24_Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies. –Chapter 25_Epidemiology of Cancer: Asian Perspective.
£179.99
Springer Verlag, Singapore Methods of Mathematical Oncology: Fusion of
Book SynopsisThis book presents original papers reflecting topics featured at the international symposium entitled “Fusion of Mathematics and Biology” and organized by the editor of the book. The symposium, held in October 2020 at Osaka University in Japan, was the core event for the final year of the research project entitled “Establishing International Research Networks of Mathematical Oncology.” The project had been carried out since April 2015 as part of the Core-to-Core Program of Japan Society for the Promotion of Science (JSPS). In this book, the editor presents collaborative research from prestigious organizations in France, the UK, and the USA. By utilizing their individual strengths and realizing the fusion of life science and mathematical science, the project achieved a combination of mathematical analysis, verification by biomedical experiments, and statistical analysis of chemical databases.Mathematics is sometimes regarded as a universal language. It is a valuable property that everyone can understand beyond the boundaries of culture, religion, and language. This unifying force of mathematics also applies to the various fields of science. Mathematical oncology has two aspects, i.e., data science and mathematical modeling, and definitely helps in the prediction and control of biological phenomena observed in cancer evolution.The topics addressed in this book represent several methods of applying mathematical modeling to scientific problems in the natural sciences. Furthermore, novel reviews are included that may motivate many mathematicians to become interested in biological research.Table of ContentsPART 1: Mathematical Modeling: D. Guan, X. Luo, and H. Gao, Constitutive Modelling of Soft Biological Tissue from Ex Vivo to In Vivo: Myocardium as an Example.- T. Colin, T. Michel, and C. Poignard, Mathematical Modeling of Gastro-intestinal Metastasis Resistance to Tyrosine Kinase Inhibitors.- Y. Tanaka and T. Yasugi, Mathematical Modeling and Experimental Verification of the Proneural Wave.- D. Kumakura and S. Nakaoka, Exploring Similarity between Embedding Dimension of Time-series Data and Flows of an Ecological Population Model.- T. Hayashi, Mathematical Modeling for Angiogenesis.- S. Collin, Corridore and C. Poignard, Floating Potential Boundary Condition in Smooth Domains in an Electroporation Context.- N. L. Othman and T. Suzuki, Free Boundary Problem of Cell Deformation and Invasion.- L. Preziosi and M. Scianna, Multi-level Mathematical Models for Cell Migration in Confined Environments.- S. Magi, Mathematical Modeling of Cancer Signaling Addressing Tumor Heterogeneity.- N. Sfakianakis and Mark A.J. Chaplain, Mathematical Modelling of Cancer Invasion: A Review.- T. Williams, A. Wilson, and N. Sfakianakis, The First Step towards the Mathematical Understanding of the Role of Matrix Metalloproteinase-8 in Cancer Invasion.- PART II: Biological Prediction: T. Ito, T. Suzuki, and Y. Murakami, Mathematical Modeling of the Dimerization of EGFR and ErbB3 in Lung Adenocarcinoma.- H. Kubota, Selective Regulation of the Insulin-Akt Pathway by Simultaneous Processing of Blood Insulin Pattern in the Liver.- D. Oikawa, N. Hatanaka, T. Suzuki, and F. Tokunaga, Mathematical Simulation of Linear Ubiquitination in T Cell Receptor-mediated NF-κB Activation Pathway.- Y. Ito, D. Minerva, S. Tasaki, M. Yoshida, T. Suzuki, and A. Goto, Time Changes in the VEGF-A Concentration Gradient Lead Neovasculature to Engage in Stair-like Growth.- N. Hatanaka, M. Futakuchi, and T. Suzuki, Mathematical Modeling of Tumor Malignancy in Bone Microenvironment.- M. Yamamoto and Jun-ichiro Inoue, Signaling Networks Involved in the Malignant Transformation of Breast Cancer.- PART III: Data Science: R. Morishita, H. Takahashi, and T. Sawasaki, Cell-free Based Protein Array Technology.- Y. Nojima and Y. Takeda, Omics Data Analysis Tools for Biomarker Discovery and the Tutorial.- M. Oyama and H. Kozuka-Hata, Integrative Network Analysis of Cancer Cell Signaling by High-resolution Proteomics.- N. Nakamura and R. Yamada, Distance-matrix-based Extraction of Motility Features from Functionally Heterogeneous Cell Populations.- S. Kawasaki, H. Hayashi, and Y. Tominaga, Data Analytic Study of Genetic Mechanism of Ovarian Carcinoma from Single Cell RNA-seq Data.
£119.99
Springer Verlag, Singapore Handbook of Oxidative Stress in Cancer:
Book SynopsisThis reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. Table of ContentsSection A: Therapeutic implications of natural compounds Chapter 1 Natural dietary alkaloids and its synthetic derivatives as oxidative stress-inducing agents for cancer therapy Chapter 2. Role of antioxidants in the treatment of hepatocellular carcinoma Chapter 3. Antioxidants in cancer prevention Chapter 4. Therapeutic potential of natural agents against oxidative stress influenced colitis-associated cancer. Chapter 5. Prevention of fertility due to chemotherapy-induced ovarian failure: Role of therapeutic antioxidant Chapter 6 Human papiloma virus (HPV) related cancer, redox state and antioxidant therapy. Chapter 7. The effect of antioxidants on chemotherapy-induced apoptosis Chapter 8. Therapeutic potential of Natural antioxidants in Chemotherapeutic Agent Cyclophosphamide Associated Cardiotoxicity Chapter 9. Therapeutic implications of phytochemicals in ROS induced cancer Chapter 10. Nutraceuticals in cancer therapy: challenges and opportunities Chapter 11. Role of dietary antioxidants in chemoprevention of nitrosamines induced carcinogenesis. Chapter 12 Role of Rosmarinus officinalis (rosemary) essential oil in oxidative stress induced brain cancer Chapter 13 Therapeutic Flavonoids in cancer: ROS-mediated mechanisms Chapter 14 Protective effect of Quercetin, Luteolin, and Fisetin via stimulating the p53 mediated signaling in cancer. Section B: Therapeutic implications of synthetic compounds Chapter 15. Nitrogen- and sulfur-containing heterocycles as dual anti-oxidant and anti-cancer agents Chapter 16. Small molecule inhibitors that target signal transduction pathways involved in oxidative stress-induced cancer: current status and future directions. Chapter 17. Polyphenolic acetates as therapeutics and adjuvant in the therapy of Cancer. Chapter 18 Application of Peptides as cancer therapeutic Chapter 19 Retinoids and reactive oxygen species in cancer cell death and therapeutics. Chapter 20. Benzophenone-2 on oxidative stress induced brain cancer Chapter 21 Salubrinal promotes cisplatin resistance in human gastric cancer cells via enhabced xCT expression and glutathione biosynthesis. Chapter 22. Beyond natural antioxidants in cancer therapy: novel synthetic approaches in harnessing oxidative stress. Chapter 23. Evaluation of chalcore-linked pyrazole pyrimidines in oxidative stress induced breast cancer Chapter 24. Engineered biopolymer for post operated cancer wound healing Chapter 25. Role of TNF-α inhibitors in oxidative stress induced ovarian cancer Chapter 26. Oxidative stress induced colon cancer: effect of Tanshienone Chapter 27. PARP inhibitor olaparib in oxidative stress induced colon cancer Chapter 28. Prevention of ROS induced gastrointestinal carcinoma by synthetic compounds Section C : Radiation and photodynamic approaches in ROS induced cancer therapeutics Chapter 29 Radiotherapy and Oxidative Stress Chapter 30. Photodynamic therapy induced oxidative stress for cancer treatment. Chapter 31 Hybrid nanomaterials for photodynamic therapy Chapter 32. Cross-talk between ROS dependent apoptotic and autophagic signalling pathways in Zn(II) pththalalocyanine photodynamic therapy in melanoma Chapter 33 Elevating the reactive oxygen species in cancer cells by photodynamic therapy: Pro-oxidative approach for cancer treatment. Section D: Non-coding RNA in therapeutics of ROS induced cancer Chapter 34 Oxidative stress mediated miRNA regulation in cancer Chapter 35 Non-coding RNAs in the regulation of voltage gated anion channels: An emerging aspect of ROS induced cancer therapeutics Chapter 36. Exosomal non-coding RNAs: A future of therapeutics in regulating oxidative stress induced breast cancer. Chapter 37 Chapter miRNA and oxidative stress cross talk in cancer Chapter 38 miRNA-mediated oxidative stress induction in cancer Chapter 39. miRNA and oxidative stress cross talk in cancer Chapter 40. A Critical approach in the Analysis of lncRNA characteristics for Cancer Therapy Chapter 41. Long non coding RNA acting as therapeutic target for oxidative stress induced pancreatic cancer Chapter 42. Short non-coding RNAs: Emerging molecular players in therapeutics of ROS induced cancer Section E : Stem cells in therapeutics of ROS induced cancer Chapter 43. Colon cancer stem cells: Target for treatment of oxidative stress induced colorectal cancer Chapter 44. Therapeutic modalities regarding ROS in leukemia and hematopoietic stem/progenitor cell perspective Chapter 45.Stemness and stromal niche: Targets in oxidative stress induced oral cancer Chapter 46. Targeting developmental pathways in Stem Cell for the therapy of Cancer Chapter 47. Cancer stem cell oxidative phosphorylation: Target for cancer therapy. Chapter 48. Targeting oxidative stress specific NRF2 in pancreatic cancer stem cells Chapter 49. Stem cells in ROS induced cancer therapy. Section F: Nanotechonology based therapeutics of ROS induced cancer Chapter 50 Role of natural polyphenols against toxicity induced by oxidative stress in cancer cells.Title: The multifaceted function of nanoparticles in modulating oxidative stress for cancer therapy Chapter 51. Emerging role of redox active nanoceria in cancer therapeutics via oxidative stress Chapter 52. Nano technology in ROS induced cancer therapy. Chapter 53. Nanotechnology-based ROS triggered therapeutic strategies in cancer. Chapter 54. Nanotechnology in cancer diagnosis and therapy Chapter 55. Emerging Nano selenium: An insight to its current Status and potentials in ROS induced cancer Prevention and Therapy' Chapter 56. Oxidative Stress-dependent Anticancer Potentiality of Nano-therapeutic Zinc Oxide Section G: Bioinformatics and system biology approach for targeting ROS in cancer therapy Chapter 57 Molecular insights into the roles of E3 ligases in ROS mediated cancer from a bioinformatics perspective Chapter 58 Elucidation of possible role of heat shock protein as potent therapeutic agent in ROS mediated cancer and its assessment through computational biology methods. Chapter 59. Dynamical methods to study interaction in proteins facilitating molecular understanding of ROS induced cancer Chapter 60. Role of Meprin in therapeutics of ROS induced cancer Chapter 61. Different databases and their utilities to in analyzing ROS mediated cancer Section H: Other aspects of therapeutics of ROS induced cancer Chapter 62 A CRISPR-Cas based therapeutics in oxidative stress-induced cancer. Chapter 63. Role of hypoxia in ROS induced cancer therapy Chapter 64. Syed Ehtaishamul Haque < Chapter 65. Molecular mechanism of oxidative stress in cancer and its therapy Chapter 65. Pro-apoptotic effects of dietary flavonoids in oxidative stress-induced cancer. Chapter 66. Redox signalling: hallmarks of cancer progression and resistance to treatments Chapter 67 Mechanistic and therapeutic crosstalk of lipid peroxidation in oxidative stress and breast cancer. Chapter 68. Targeting Myeloid Leukemia via ROS and Oxidative Stress Chapter 69. Immunotherapeutic approaches for treatment of oxidative stress in haematological malignancies Chapter 70 Application of regulating ROS in overcoming cancer multidrug resistance Chapter 71. Y-Box binding protein 1: A promising therapeutic target for cancer relapses. Chapter 72. Microbes induced oxidative stress for cancer development and therapeutic role of probiotics Chapter 73. Implications of ROS in Endometriosis and Ovarian cancer: Potential avenue in cancer therapy. Chapter 74.Implications of oxidative stress in autophagy and its connection with apoptosis in carcinogenesis Chapter 75. Role of Forkhead box proteins regulating epithelial mesenchymal transition in breast cancer.
£404.99
Springer Verlag, Singapore Immuno-Oncology Crosstalk and Metabolism
Book SynopsisThis book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.Table of Contents1 Cancer Metabolism and Aggressive Tumor Behaviour.- 2 Immune Cell Metabolism and Function.- 3 Cancer Cell Metabolism Effecting Immune function.- 4 Immune Cell Metabolites as Fuel for Cancer Cells.- 5 Immuno-Onco metabolism and Resistance to Therapy.- 6 Targeting Immuno-Onco metaolism in Cancers.- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
£132.99
Springer Verlag, Singapore Cancer in the Arab World
Book SynopsisThis is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country’s medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.Table of Contents 1 Introduction 2 General Oncology Care in Algeria 3 General Oncology Care in Bahrain 4 General Oncology Care in Egypt 5 General Oncology Care in Iraq 6 General Oncology Care in Jordan 7 General Oncology Care in Kuwait 8 General Oncology Care in Lebanon 9 General Oncology Care in Libya 10 General Oncology Care in Mauritania 11 General Oncology Care in Morocco 12 General Oncology Care in Oman 13 General Oncology Care in Palestine 14 General Oncology Care in the Kingdom of Saudi Arabia 15 General Oncology Care in Somalia 16 General Oncology Care in Sudan 17 General Oncology Care in Syria 18 General Oncology Care in Tunisia 19 General oncology care in the UAE 20 General Oncology Care in the Republic of Yemen 21 General Oncology Care in Qatar, Comoros & Djibouti 22 Breast Cancer in the Arab World 23 Colorectal Cancer in the Arab World 24 Palliative Care in the Arab World 25 Cancer Research in the Arab World 26 Pediatric Oncology in the Arab World 27 Challenges Associated with Medical Travel for Cancer Patients in the Arab World: A Systematic Review 28 Radiation Therapy in Arab World 29 Cancer Care During War and Conflict
£42.74
Springer Verlag, Singapore Cancer in the Arab World
Book SynopsisThis is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country’s medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.Table of Contents 1 Introduction 2 General Oncology Care in Algeria 3 General Oncology Care in Bahrain 4 General Oncology Care in Egypt 5 General Oncology Care in Iraq 6 General Oncology Care in Jordan 7 General Oncology Care in Kuwait 8 General Oncology Care in Lebanon 9 General Oncology Care in Libya 10 General Oncology Care in Mauritania 11 General Oncology Care in Morocco 12 General Oncology Care in Oman 13 General Oncology Care in Palestine 14 General Oncology Care in the Kingdom of Saudi Arabia 15 General Oncology Care in Somalia 16 General Oncology Care in Sudan 17 General Oncology Care in Syria 18 General Oncology Care in Tunisia 19 General oncology care in the UAE 20 General Oncology Care in the Republic of Yemen 21 General Oncology Care in Qatar, Comoros & Djibouti 22 Breast Cancer in the Arab World 23 Colorectal Cancer in the Arab World 24 Palliative Care in the Arab World 25 Cancer Research in the Arab World 26 Pediatric Oncology in the Arab World 27 Challenges Associated with Medical Travel for Cancer Patients in the Arab World: A Systematic Review 28 Radiation Therapy in Arab World 29 Cancer Care During War and Conflict
£33.24
Springer Verlag, Singapore Role of MicroRNAs in Cancers
Book SynopsisThis book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.Table of ContentsChapter 1. Introduction to microRNAs and cancers.- Chapter 2. microRNAs and cancer signaling pathways.- Chapter 3. Role of microRNAs in cell growth proliferation and tumorigenesis.- Chapter 4. Impact of microRNAs in cell adhesion and tumor angiogenesis.- Chapter 5. Modulation of oxidative stress by microRNAs in cancers.- Chapter 6. microRNAs targeting tumor microenvironment and immune modulation.- Chapter 7. Circulating miRNA in prognosis, diagnosis and their role in controlling the fate of cancer stem cells.- Chapter 8. The role of miRNAs in the regulation of drug resistance among different cancers.- Chapter 9. The mechanisms of miRNA deregulation in cancer outbreak.- Chapter 10. Bioinformatic profiling of miRNAs in Cancers.
£132.99
Springer Verlag, Singapore Hormone Related Cancer Mechanistic and
Book SynopsisThe nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.Table of ContentsChapter 1. Conventional Treatment Approaches in Hormonal Cancer Treatment and Challenges.- Chapter 2. Concept of Nanomedicine in Endocrine Hormone Cancer Treatment.- Chapter 3. Progress of Cancer Nanomedicine, Clinical Hurdles and Opportunities.- Chapter 4. Emergence of Nanohybrids in Hormonal Cancer Targeted Therapy.- Chapter 5. Conventional to Nanoscale-Based Carrier System in Management of Ovarian Cancer.- Chapter 6. Pancreatic Cancer Nanoparticles Targeted Therapy via Epidermal Growth Factor Receptor.- Chapter 7. Nanocarriers Based Targeted Therapies for Pancreatic Cancer and Challenges Ahead.- Chapter 8. Pancreatic Cancer Treatment by Using of Theranostics Nanoparticles.- Chapter 9. Nanomedicine Based Combinational Therapy for Breast Cancer.- Chapter 10. Nano-Liposomal System for Breast Cancer Therapy.- Chapter 11. Conventional to Nanotherapeutic Strategies against Triple-Negative Breast Cancer.- Chapter 12. Effect of Thymoquinone and Its Delivery Through Using of Nanomedicine in Benign Prostatic Hyperplasia.- Chapter 13. Concept of Nanotechnology in Management of Neuroendocrine Tumours.- Chapter 14. Neurocognitive Underpinning of Neurological Disorders: The Role of Default Mode Network.- Chapter 15. Neuroendocrine Carcinoma of The Endometrium: Conventional Treatment Approach to Nanomedicine.- Chapter 16. Effective Luteinizing Hormone Drug Delivery by Gold Nanoparticles in Hormonal Cancer Treatment.- Chapter 17. Regulatory Landscapes in Approval of Cancer Vaccines.
£116.99
Springer Verlag, Singapore Physical Therapy and Research in Patients with
Book SynopsisThis collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study. Table of ContentsPart 1 Physical Function and Health Related Quality of Life Chapter 1 Physical function and health related QOL in cancer survivors Chapter 2 Physical function and health-related quality of life after breast cancer surgery Chapter 3 Physical function and health-related quality of life in patients with gastrointestinal cancer Chapter 4 Physical function and health related QOL in surgically treated patients with malignant pleural mesothelioma Chapter 5 Muscle mass, cachexia, and health-related quality of life in patients with hematologic malignancies Chapter 6 Exercise capacity and health-related quality of life in patients after lung resection for non-small cell lung cancer Part 2 Physical Exercise Chapter 7 Effect of physical exercise on physical function and survival rate in cancer patients Chapter 8 Exercise therapy on muscle mass and physical function in patients undergoing allogeneic hematopoietic stem cell transplantation Chapter 9 Physical exercise and immune function in patients with hematological malignancies Chapter 10 Exercise protocols for counteracting cancer cachexia-related declines in muscle mass and strength and the clinical assessment of skeletal muscle Chapter 11 Physical Exercise and Skeletal Muscle Adaptation in Cancer Cachexia Chapter 12 Physical function and physical activity in patients with advanced lung cancer Chapter 13 Physical Activity in Patients with Breast Cancer Part 3 Physical Function and Other Symptom Chapter 14 Multiple frailty in elderly patients with cancer Chapter 15 Postoperative complications in patients with esophageal cancer Chapter 16 Cancer-related lymphedema and obesity Chapter 17 Cancer-related pain and effects of non-pharmacologic intervention Chapter 18 Nutrition and daily activities in older patients after gastrectomy Chapter 19 Frailty and mental health in older patients with gastrointestinal cancer Chapter 20 Physical function and nutrition in patients with hematological malignancies Chapter 21 Physical Function and Nutrition in Patients with Esophageal Cancer and Head and Neck Cancer Part 4 Skeletal Muscle Chapter 22 Skeletal muscle oxygenation in patients with malignant hematopoietic disease Chapter 23 Sarcopenia and physical performance in patients with cancer Chapter 24 Cachexia and postoperative outcomes in elderly patients with gastrointestinal cancer Chapter 25 Mechanism of skeletal muscle atrophy using a mice cancer cachexia model.
£170.99
Springer Verlag, Singapore The MicroRNA Quantum Code Book
Book SynopsisThis book tells the story of the discovery of microRNA (miRNA) quantum code, the basic theory of biological data science for medical investigation with miRNA, to its implementation. It explains the use of a new algorithm called the miRNA entangling target sorter (METS), based on the quantum computation algorithm, to give the etiologic analysis for diseases such as cancer, infectious diseases, and age-related disorders. Providing detailed descriptions to make the METS algorithm simple to grasp, it also explains the accumulated cutting-edged data for human diseases utilizing artificial intelligence (AI) for quantum miRNA language (miRNA qubit) (MIRAI). Further, it describes a discovery story for quantum miRNA surveillance against tumors and quantum miRNA immunity against viruses. Since this is a multidisciplinary field of study, crucial details on physics, mathematics, computer science, data science, virology, immunology, oncology, pathology, and biology are supplied.This book will support professional advancement for scientists, clinicians, educators, students, and science enthusiasts. The reader's knowledge of the subject and its practical medical applications will be enriched by the wealth of informative figures and supporting data.Table of ContentsRNA Controls RNA.- MicroRNA Qubit.- Matrix Multiplication for MicroRNA Qubit.- MicroRNA Quantum Computing.- Vital METS/MIRAI.- Etiologic Analysis for Human cancer.- Encounter with the unknown.- Diabetes Mellitus: Quantum microRNA Language with Artificial Intelligence (MIRAI) as an Early Diagnostic Tool for Type II Diabetes Mellitus for Sustainable Healthcare.- Thyroid Cancer: Quantum microRNA Language/Artificial Intelligence (MIRAI)-Based Etiologic Analysis of Thyroid Cancer by Serum/Plasma miRNA Panel Data.- Metabolic Disease and Alzheimer’s Disease.- Quantum MiRNA Immunity and Quantum MiRNA Surveillance.- Quantum MiRNA code.
£104.49
Springer Verlag, Singapore Therapeutic potential of Cell Cycle Kinases in
Book SynopsisThis book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer. Table of ContentsChapter 1 An introduction to breast cancer.- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators.- Chapter 4 Cell cycle and cancer.- Chapter 5 cell cycle dysregulation in breast cancer.- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation.- Chapter 7 Breast tumor micro environment and CDks.- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis.- Chapter 9 CDK1 Dysregulation in Breast Cancer.- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers.- Chapter 11 Therapeutic implications of CDKs in Breast Cancer.- Chapter 12 Novel CDK Inhibitors in Breast Cancer.- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach.- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer.- Chapter 15 CDk inhibitor for treatment of breast cancer.- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer.- Chapter 17 Different cyclins and their significance in Breast cancer.
£151.99
Springer Verlag, Singapore Targeted Cancer Therapy in Biomedical Engineering
Book SynopsisThis book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs.Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes.This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.Table of ContentsStrategies for Cancer Targeting: Novel Drug Delivery Systems Opportunities and Future Challenges.- Implementation of Biomedical Engineering Tools in Targeted Cancer Therapy: Challenges and Opportunities.- Exploration of tissue-engineered systems for cancer research.- Advancement of Tissue Engineered in Cancer treatment.- Immunotherapy: Targeting Cancer Cells.- Bioinformatics Tools to Discover and Validate Cancer Biomarkers.- Application of Biomaterials in Cancer Research.- Engineered Tissue in Cancer Research: Techniques, Challenges and Current status.- CADD for Cancer Therapy: Current and Future Perspective.- Leveraging Advancement in Robotics in the Treatment of Cancer.-Innovative Biomedical Equipment for Diagnosis of Cancer.- Detection of Cancer Biomarker by Advanced Biosensor.- Advancement of Nanocarrier Based Engineering for Specific Drug Delivery for Cancer Therapy.- Nano-Drug Delivery Systems for Tumor-Targeting: Overcoming the Limitations of Chemotherapy.- Microfluidics and cancer treatment: Emerging concept of Biomedical Engineering.- Recent Developments In Two-Dimensional (2D) Inorganic Nanomaterials-Based Photo-Thermal Therapy for Cancer Theranostics.- Cyclodextrins and Cyclodextrin-Based Nanosponges for Anti-Cancer Drug and Nutraceutical Delivery.- Theranostic Approaches for Diagnosis and Treatment of Cancer: An Update.- MicroRNA Biomarkers for Oral Cancer: A Meta-Analytic Review.- Application of Magnetic Nanoparticles in Cancer: Drug Delivery and Therapy.- Vehicles for Delivery of Therapeutic Agent for Cancer Therapy.- Photothermal Therapy for Cancer Treatment.- Tool and Techniques on Computer -Aided Drug Design for Targeted Cancer Therapy.- Importance of Gut Microbiome-based Therapeutics in Cancer Treatment.- Computational Tools for Drug Discovery of Anticancer Therapy.- Stem Cell Therapy in Cancer
£113.99
Springer Hypoxia and Tumor Microenvironment
Book Synopsis
£179.99
Springer Molecular Targets in Cancer Therapy
Book Synopsis.- Chapter 1: Structural features and Signaling mechanisms of Receptor Tyrosine Kinases in Cancer.- Chapter 2: Cell Death Pathways in Cancer and Potential Therapeutic Targets.- Chapter 3: Telomerase as a Target for Cancer Therapy .- Chapter 4: Molecular targets of epigenetic regulators.- Chapter 5: Signaling Pathways in Cancer Drug Resistance: Potential Targets for Therapeutic Intervention .- Chapter 6: Targeting Angiogenesis for Cancer Prevention and Therapy .- Chapter 7: Inflammation as a target in cancer therapy.- Chapter 8: Epithelial-Mesenchymal Transition: Insights into Molecular Pathways and Cancer Therapeutics.- Chapter 9: Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy .- Chapter 10:Genomic instability as a Therapeutic Target: Advancements from Experimental Research to Clinical Application.- Chapter 11:Targeting innate immunity: A New Door to Cancer Therapy .- Chapter 12:Metabolic Targeting in Cancer Therapy: Strategies, Challenges, and Personalized Approaches.
£142.49
Springer The Microbiome and Cancer
Book Synopsis.- Chapter 1_The Microbiome And Cancer: Understanding The Role Of Microorganisms In Tumor Development And Treatment..- Chapter 2_Microbiome And Its Impact On Human Health: Microbiome In Various Body Organs And Its Association With Human Health And Disease..- Chapter 3_Viral Infections And Different Cancers..- Chapter 4_Role Of Hcv In Hepatocellular Carcinoma..- Chapter 5_Cancers Associated With Epstein-Barr Virus..- Chapter 6_Human Papillomavirus Leading To Urogenital, Head And Neck Cancer..- Chapter 7_Kaposi's Sarcoma Associated Herpes Virus..- Chapter 8_Cancer And Fungal Infections..- Chapter 9_Microorganisms And Other Cancers..- Chapter 10_Protists And Cancer..- Chapter 11_Cancer Management And Therapies Related To Microorganisms.
£179.99
Springer Evidence in Breast Cancer
Book SynopsisPart 1. Prevention, Screening& Evaluation: .- 1. Epidemiology of Breast cancer.- 2. ANATOMY OF THE BREAST.- 3. Chemoprevention in breast cancer.- 4. BRCA and other novel mutations: Target Population and Risk Reduction Methods.- 5. Breast cancer screening.- . Part 2. Breast Cancer Diagnosis, Pathology & Gene Signature: .- 6. Imaging in breast cancer.- 7. Radiology interventions in breast cancer.- 8. Functional imaging in breast cancer: Focus on PET-CT.- 9. Workup and staging for breast cancer.- 10. Pathology & Molecular Classification of Breast Cancer.- 11. Gene Signatures in Management of Breast Cancer.- . Part 3. Management of early and LABC Breast Cancer: .- 12. Introduction to oncoplastic breast conservation surgery (OPBCS).- 13. Axillary management in breast cancer.- 14. Mastectomy and its relevance in today's era.- 15. Breast reconstruction: evidence and challenges.- 16. Evolution of radiation in early breast cancer.- 17. APBI- Current Status and techniques.- 18. Tailoring of Radiation after NACT.- 19. Regional Nodal Irradiation.- 20. Tailoring Post Mastectomy Radiotherapy .- 21. Target delineation, Radiation planning and evaluation.- 22. Radiation planning and evaluation.- 23. Management of early and LABC Breast Cancer: Chemotherapy and targeted therapy in breast cancer.- 24. PERSONALIZATION OF ENDOCRINE THERAPY IN HORMONE RECEPTOR POSITIVE BREAST CANCER.- 25. Evolving Technological Advances in Management of Early and Locally Advanced Breast Cancers.- . Part 4. Management of Metastatic Breast Cancer (MBC): .- 26. Role of surgery in metastatic breast cancer and its justification.- 27. Oligometastatic breast cancer.- 28. Systemic Therapy for Hormone positive breast cancer.- 29. Tailoring treatment in Hormone negative carcinoma breast .- . Part 5. Special Issues Part I: .- 30. High-Risk Lesion of Breast.- 31. Management of inflammatory breast cancer.- 32. Challenges in management of Breast cancer in young women.- 33. BREAST CANCER IN ELDERLY FEMALE.- 34. Pregnancy associated breast cancer.- 35. Management of non IDC histology breast cancer.- . Part 6. Special Issues Part II .- 36. Management of Non-Palpable Breast Lesion.- 37. Evaluation of Breast Cancer at Recurrence.- 38. Current Evidence In The Management Of Recrrent Breast Cancer.- 39. Skin Sparing Mastectomy.- 40. Triple negative breast cancer: Burden, Biology and Challenges and Management.- . Part 7. Adjuvant treatment for DCIS.- 41. Adjuvant treatment for DCIS.- . Part 8. Special Issues Part III.- 42. Surveillance in Breast Cancer Survivors.- 43. Supportive and Palliative care in Breast Cancer.- 44. Radiation and Chemotherapy induced Cardiac toxicity in Breast cancer.- 45. Bone Health in Breast Cancer Patients.- 46. Breast cancer: Mental Health and Psychosocial Impact.- 47. Breast Cancer Rehabilitation.- 48. Preoperative radiation in breast cancer.
£161.99
Springer Verlag, Singapore Practical Inverse Problems and Their Prospects:
Book SynopsisThis book comprises select proceedings of the workshop “Practical inverse problems and their prospects” held online by zoom, from Mar 2nd to Mar. 4th, 2022, supported by Institute of Mathematics for Industry, Kyushu University focusing on cutting-edge research carried out in the areas of practical inverse problems based on industry-academia and interdisciplinary collaborations.Various themes on practical inverse problems covered in this book are medical imaging, non-destructive and non-invasive inspections, viscoelastic waves, remote sensing, infrared light tomography, maintenance of infrastructure, and so on, and mathematical theories in inverse problems are also handled in these proceedings.All papers in this book are written by qualified authors in the practical inverse problems area and also the papers are newly announced. Readers can get leading-edge information on practical inverse problems.Table of Contents
£170.99
Springer Verlag, Singapore Tata Memorial Center Textbook of Oncology
Book SynopsisWritten by experts from the globally renowned Tata Memorial Centre (TMC) in Mumbai, this book provides a crisp and highly distilled review of clinical aspects of oncology, primarily for postgraduate students and fellows. TMC Textbook of Oncology covers the basic principles of oncology, solid tumors, hematologic cancers, and special topics such as oncological emergencies, pain management, intensive care, and the impact of comorbidities. Chapters have been structured uniformly covering epidemiology, clinical presentation and evaluation, principles of multidisciplinary management and stage-wise management and prognosis. Each chapter has been further extensively reviewed by an eminent national or international expert.This textbook is an extension of the annual Evidence Based Meetings that TMC has conducted since 2002, wherein experts have distilled the evidence for diagnostic and therapeutic strategies in oncology not only on strength of evidence but also on applicability in a variety of settings. The Textbook will provide the reader with a glimpse into the clinical decision-making process at TMC, which is an institution that provides cancer care to all sections of the society.An essential read for all students and practitioners in this field as a reference as well as practical aid in clinical decision making. Table of ContentsPart I. Basic Principles.- Chapter 1. Basic and Translational Science in Oncology.- Chapter 2. Principles of Surgical Oncology.- Chapter 3. Radiation Oncology.- Chapter 4. Principles of Systemic Treatment of Cancer.- Chapter 5. General Overview of Pediatric Oncology: Epidemiology and Challenges in Childhood.- Chapter 6. Principles of Oncopathology.- Chapter 7. Oncologic Hematopathology.- Chapter 8. Microbiology in Oncology.- Chapter 9. Principles of Imaging in Oncology.- Chapter 10. Nuclear Medicine in Oncology.- Chapter 11. Interventional Radiology in Oncology.- Chapter 12. Anaesthesia in Oncology.- Chapter 13. Transfusion Medicine in Oncology.- Chapter 14. Palliative Care in Oncology.- Chapter 15. Clinical Pharmacology in Oncology.- Chapter 16. Cancer Staging.- Part II. Public Health.- Chapter 17. Cancer Registration in India: A Tool to Estimate Incidence and Mortality.- Chapter 18. Cancer Screening in India.- Part III. Hematological Malignancies.- Chapter 19. Adult Lymphoblastic Leukemias.- Chapter 20. Adult Lymphomas.- Chapter 21. Adult Myeloproliferative Disorders/ Myelodysplastic Syndromes/Overlap Syndromes.- Chapter 22. Plasma Cell Dyscrasia.- Chapter 23. Immunodeficiency-associated Lymphoproliferative Disorders.- Chapter 24. Histiocytic and Dendritic Cell Neoplasms.- Chapter 25. Pediatric Acute Leukemias.- Chapter 26. Pediatric Hodgkin Lymphoma.- Chapter 27. Pediatric Myeloproliferative Disorders /Myelodysplastic Syndromes/Overlap Syndromes.- Chapter 28. Hematopoietic Stem Cell Transplantation.- Part IV. Solid Tumors.- Chapter 29. Central Nervous System (CNS) Tumours.- Chapter 30. Head and Neck Cancers.- Chapter 31. Thyroid and Parathyroid Cancer.- Chapter 32. Management of Breast Cancer.- Chapter 33. Non-Small Cell Lung Cancer.- Chapter 34. Small Cell Lung Cancer (SCLC).- Chapter 35. Mediastinal Tumours.- Chapter 36. Esophageal Cancer.- Chapter 37. Biliary Tract Cancer.- Chapter 38. Liver Cancer.- Chapter 39. Gastric Cancer.- Chapter 40. Colon Cancer.- Chapter 41. Small Intestine Cancer.- Chapter 42. Anal Canal Cancer.- Chapter 43. Pancreatic Cancer.- Chapter 44. Gastrointestinal Stromal Tumor.- Chapter 45. Gastroentero-pancreatic Neuroendocrine Tumours.- Chapter 46. Rectal Cancer.- Chapter 47. Renal Cancer.- Chapter 48. Adrenal Cancer.- Chapter 49. Urinary Bladder Cancer.- Chapter 50. Upper Tract Urothelial Cancer.- Chapter 51. Prostate Cancer.- Chapter 52. Penile Cancer.- Chapter 53.Testicular Cancer.- Chapter 54. Uterine Cancer.- Chapter 55. Cervical Cancer.- Chapter 56. Vulva and Vaginal Cancers.- Chapter 57. Gestational Trophoblastic Disease.- Chapter 58. Epithelial Ovarian Cancer.- Chapter 59. Non-Epithelial Ovarian Cancer.- Chapter 60. Bone Sarcomas.- Chapter 61. Soft Tissue Sarcoma: Principles of Management.- Chapter 62. Ewing Sarcoma.- Chapter 63. Wilms Tumor.- Chapter 64. Neuroblastoma.- Chapter 65. Retinoblastoma.- Chapter 66. Rare Pediatric Tumors.- Chapter 67. Childhood and Adolescent Extracranial Germ Cell Tumors.- Chapter 68. Hepatoblastoma.- Part V. Special Topics.- Chapter 69. Oncological Emergencies.- Chapter 70. Pain Management in Oncology.- Chapter 71. Intensive Care in Oncology.- Chapter 72. Vascular Access in Oncology.- Chapter 73. Comorbidities in the Cancer Patient.- Chapter 74. Hereditary Cancers: Genetic Counselling, Genetic Testing and Risk Management.- Chapter 75. Library and Information Needs in Oncology: In Pursuit of Information.- Chapter 76. Oncology Training and Education in India: The Tata Memorial Centre (TMC) Perspective.
£161.99
Springer Molecular Biomarkers for Cancer Diagnosis and
Book SynopsisChapter 1. Molecular Biomarkers of Cancer and their Diagnostic Applications.- Chapter 2. Statistical Models in Cancer Management.- Chapter 3. Deep Learning Techniques for Computer Aided Diagnosis of Various Cancers.- Chapter 4. Machine Learning Techniques in Computer Aided Diagnosis for Effective Detection of Malignant Tissues.- Chapter 5. Molecular Mechanisms of Oncogenesis.- Chapter 6. Application of CRISPR in Cancer Research and Treatment.- Chapter 7. Nanobiosensing Platforms for Early Detection of Cancer.- Chapter 8. Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy.- Chapter 9. Central Nervous System Tumors.- Chapter 10. Biomedical Approaches in the Research and Management of Head and Neck Squamous Cell Carcinoma.- Chapter 11. Applications of Molecular Biology and Biomedical Advances in Ocular Oncology.- Chapter 12. Molecular Markers in Oral Cancer.- Chapter 13. MicroRNAs as Tools for Early Diagnosis and Predicting Response to Therapy in Oe
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Springer Verlag, Singapore Diagnostic Imaging of Lung Cancers
Book SynopsisThis book systematically covers diagnostic imaging of lung cancers, including epithelial tumors, mesenchymal tumors, and hematolymphoid tumors, with emphasis on relationship between classification, molecular pathology, clinical findings, imaging manifestations and pathological discussion.
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Springer Verlag, Singapore Recent Topics on Prevention Diagnosis and
Book SynopsisThis book provides a practical overview of a central topic in cervical cancer concerning human papillomavirus (HPV), prevention, cervical cancer screening, diagnosis, and treatment.
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Editorial Sirio Cancer
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Springer Oncothermia: Principles and Practices
Book SynopsisOncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co. Table of ContentsOBJECTIVE OF THE BOOK 1. ONCOLOGY – TREATMENTS AND THEIR LIMITS 1.1. CANCER – SHORT HISTORY AND EFFORTS TO CURE 1.1.1. Historical notes 1.1.2. The “war” against cancer 1.2. PARADIGM AND CHALLENGES OF ONCOTHERAPIES 1.3. LIMITATIONS OF ONCOTHERAPIES – QUEST FOR STEPS FORWARD 1.3.1. Medical challenge of oncotherapies 1.3.2. Ethical challenge of oncotherapies 1.3.3. Evaluation challenge of the results 2. HYPERTHERMIA RESULTS AND CHALLENGES 2.1. HYPERTHERMIA APPROACH 2.1.1. Definition of hyperthermia in oncology 2.1.2. Basic concepts of oncological hyperthermia 2.1.3. Technical variations of hyperthermia in oncology 2.2. EFFECTS OF HYPERTHERMIA 2.2.1. Higher baseline temperature 2.2.2. Vascular changes 2.2.3. Cellular membrane changes 2.2.4. Lactic acid formation 2.2.5. ATP depletion 2.2.6. Altered DNA replication 2.2.7. Enhanced immune reaction 2.2.8. Pain reduction 2.2.9. Selective gain of the heat-resistance 2.3. CLINICAL ONCOLOGICAL HYPERTHERMIA 2.3.1. Local and whole-body heating 2.3.2. Hyperthemia as a complementary method 2.4. HYPERTHERMIA SUCCESSES 2.4.1. Brain tumor treatments by hyperthermia 2.4.2. Pancreas tumor treatment by hyperthermia 2.4.3. Lung and bronchus 2.4.4. Hepatocellular carcinoma and metastatic tumors of liver 2.4.5. Colo-rectal tumors 2.4.6. Esophagus 2.4.7. Head and neck localizations 2.4.8. Gastric tumors 2.4.9. Breast tumors 2.4.10. Other localizations treated by hyperthermia 2.5. HYPERTHERMIA CHALLENGES IN ONCOLOGY 2.5.1. Challenge of selection and focus 2.5.2. Challenge of temperature 2.5.3. Medical challenges of hyperthermia in oncology 2.5.4. Challenge on quality control and dosimetry of hyperthermia 2.5.5. What we expect? 2.5.6. Possible solution: oncothermia 3. THERMO-BIO-PHYSICS 3.1. FACTORS OF PHYSIOLOGY HEATING 3.2. BIOTHERMODYNAMICS 3.2.1. Energy, heat and temperature 3.2.2. Energy of the chemical bonds and reactions 3.2.3. Energy sources and driving forces 3.2.4. Energy and structure 3.2.5. Energetics of malignant cells 3.2.6. “Non-thermal” effects – thermodynamial approach 3.3. BIOELECTRODYNAMICS 3.3.1. Basic interactions 3.3.2. The bioimpedance 3.3.3. “Nonthermal effects” – electrodynamical appraoch 3.3.4. “Non-thermal effects” – approach of electric currents 3.3.5. Membrane effects 3.3.6. Stochastic processes 3.3.7. Noises and signals 3.3.8. Resonances 3.3.9. Modulation-demodulation 3.3.10. Special field-effects of bio-systems 4. ONCOTHERMIA – NEW KIND OF ONCOLOGIC HYPERTHERMIA 4.1. ONCOTHERMIA CHARACTERISTICS 4.1.1. Electro Cancer Therapy (ECT) 4.1.2. Concept of oncothermia 4.1.3. Pennes equation revised 4.1.4. Thermal limit problem 4.1.5. Energy-transfer through the body surface 4.1.6. Penetration depth 4.1.7. Arrangement of electrodes 4.1.8. Far from equilibrium 4.1.9. Energy intake and temperature 4.1.10. Macroscopic focusing on the tumor 4.1.11. Heating the extracellular electrolyte 4.1.12. Temperature gradient and heat-flow on the membrane 4.1.13. Changes of the membrane potential 4.1.14. Membrane damage by constrained ion-currents 4.1.15. Effect on cell-cell connections 4.1.16. Oncotherm comparison 4.2. ONCOTHERMIA TREATMENT GUIDELINES 4.2.1. Treatment planning 4.2.2. Treatment consensus 4.3. COMPLEMENTARY APPLICATIONS 4.3.1. Complementary to radiotherapy 4.3.2. Complementary to chemotherapy 4.3.3. Clinical toxicity, safety 4.4. ONCOTHERMIA CASE REPORTS 4.4.1. Near eye treatments 4.4.2. Brain cases 4.4.3. Gynecology cases 4.4.4. Gastrointestinal cases 4.4.5. Pulmonary cases 4.4.6. Other cases 4.5. EVALUATION OF ONCOTHERMIA STUDIES 4.5.1. Evaluation conditions 4.5.2. Evaluation methods 4.6. GENERAL OVERVIEW ON A LARGE PATIENT’S POOL 4.7. BRAIN STUDIES 4.7.1. Brain safety study (Phase I) 4.7.2. Brain efficacy study (Phase II) 4.7.3. Hungarian brain glioma study 4.7.4. Small prospective, double arm brain glioma study 4.7.5. Study of brain gliomas with local clinical responses 4.7.6. Brain glioma study with relapses 4.7.7. Bicentral brain glioma study 4.7.8. Oncothermia for heavy pre-treated & relapsed brain gliomas 4.7.9. Study of metastatic brain tumors 4.7.10. Comparison of oncothermia brain studies 4.8. PANCREAS STUDIES 4.8.1. Pancreas efficacy study I. 4.8.2. Pancreas efficacy study II. (HTT) 4.8.3. Additional historical control to HTT pancreas study 4.8.4. Comparison of pancreas efficacy studies I. & II. 4.8.5. Pancreas efficacy study III. 4.8.6. Pancreas efficacy study IV. 4.8.7. Other oncothermia pancreas studies and their comparison 4.9. LUNG STUDIES 4.9.1. Oncothermia lung study I. 4.9.2. Oncothermia lung study II. 4.9.3. Meta-analysis of oncothermia lung studies 4.9.4. Compare to historical control 4.10. LIVER STUDIES 4.10.1. Study of liver metastases colorectal origine 4.10.2. Study of advanced liver metastases colorectal origine II. 4.10.3. Comparison study of treatment lines of colorectal liver metastases 4.10.4. Study of platinum derivatives with oncothermia for liver metastases from colorectal origine 4.10.5. Study of liver metastases rectal origine 4.10.6. Study of liver metastases various origine 4.10.7. Study of far advanced liver metastases various origines. Comparison of complementary therapies 4.11. COMPARISON OF STUDIES OF LIVER METASTASES 4.12. GYNECOLOGICAL (PELVIC) CANCER STUDY 4.12.1. Ovary study 4.12.2. Uterine corpus cancer 4.12.3. Uterine cervix 4.12.4. Comparison of oncothermia in pelvic gynecology 4.13. BREAST STUDY 4.14. ESOPHAGUS STUDY 4.14.1. Esophagus study I. 4.14.2. Esophagus study II. 4.15. STOMACH STUDY 4.16. COLO-RECTAL STUDIES 4.16.1. Preoperative oncothermia for rectum carcinoma 4.16.2. Colorectal carcinoma study 4.17. BONE STUDIES 4.17.1. Refractory bone metastases complementary to radiotherapy 4.17.2. Advanced bone metastases monotherapy 4.17.3. Osteosarcoma study 4.18. KIDNEY STUDY 4.19. HEAD AND NECK STUDY 4.20. URINARY BLADDER MALIGNANCIES 4.21. SOFT-TISSUE MALIGNANCIES 4.22. PROSTATE STUDY 4.23. ONCOTHERMIA PERSPECTIVES APPENDIX 1 ENTROPY AND TEMPERATURE APPENDIX 2 THERMODYNAMICS – ONSAGER’S RELATION APPENDIX 3 SELF-SIMILARITY AND BIOSCALING APPENDIX 4 ENERGY SUPPLY BY DEMANDS APPENDIX 5 ONCOGENIC GROWTH APPENDIX 6 BASIC BIOELECTROMAGNETICS APPENDIX 7 BIOIMPEDANCE OF CELLS & TISSUES APPENDIX 8 BOUNDARY CONDITIONS APPENDIX 9 DIRECT CURRENT APPLICATIONS APPENDIX 10 DEVELOPMENT OF EDEMA APPENDIX 11 WARBURG-IMPEDANCE APPENDIX 12 CELL-MEMBRANE PERMEABILITY APPENDIX 13 STOCHASTIC PROCESSES – PINK-NOISE APPENDIX 14 AUTOCORRELATION APPENDIX 15 DISSIPATIVE SYSTEMS APPENDIX 16 STOCHASTIC RESONANCE APPENDIX 17 RESONANCE OF ENZYMATIC REACTIONS APPENDIX 18 DEMODULATION BY STOCHASTIC RESONANCE APPENDIX 19 NON-LINEAR EFFECTS OF ENERGY-FLOW APPENDIX 20 PRINCIPLE OF MINIMAL ENERGY-DISPERSION APPENDIX 21 CHARGE-INHOMOGENETIES APPENDIX 22 PENNES’ EQUATION APPENDIX 23 PENNES’ EQUATION IS REVISED APPENDIX 24 SELF-FOCUSING APPENDIX 25 DYNAMISM OF TEMPERATURE ON THE MEMBRANE APPENDIX 26 CHANGES OF THE MEMBRANE-POTENTIAL APPENDIX 27 MEMBRANE DAMAGE BY INCREASING PRESSURE APPENDIX 28 DYNAMICS OF ADHERENT BONDS APPENDIX 29 MODULATION EFFECT APPENDIX 30 COMPONENTS OF CELL-DESTRUCTION APPENDIX 31 EXPERIMENTAL CONDITIONS IN VITRO APPENDIX 32 EXPERIMENTAL CONDITIONS IN VIVO APPENDIX 33 CONSIDERATIONS FOR EXPERIMENTAL SETUP IN VIVO APPENDIX 34 VALIDATION OF MORPHOLOGIC EVALUATION APPENDIX 35 EVALUATION OF SURVIVAL STUDY WITH SINGLE ARM 5. ACKNOWLEDGEMENT 6. REFERENCES
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Taylor & Francis Ltd Advanced Skin Cancer
Book SynopsisAdvanced skin cancer is one that has already metastasized beyond its primary origin, or one that has invaded underlying tissues such that surgical resection either is technically impossible or would lead to an unacceptable functional or cosmetic outcome. These skin cancers present a complex problem that requires the input of multiple specialties to delineate the best management plan. National guidelines utilize the best available data to guide management decisions. However, there is considerable leeway within the guidelines, enabling the ultimate care decision to be molded to best fit each individual patient. This book aims to provide instructional examples of patient cases where the input of the multidisciplinary team is critical in providing the most suitable care plan for the patient.CONTENTS: Melanoma * Squamous Cell Carcinoma * Basal Cell Carcinoma * Cutaneous Lymphoma * Kaposi's Sarcoma * Dermatofibrosarcoma Protuberans * Merkel Cell Carcinoma * Rare CaTrade Review"...provides an understanding of the depth of decision-making involved by multiple specialists in the field".- Doody's ReviewTable of ContentsMelanoma * Squamous Cell Carcinoma * Basal Cell Carcinoma * Cutaneous Lymphoma * Kaposi’s Sarcoma * Dermatofibrosarcoma Protuberans * Merkel Cell Carcinoma * Rare Cancer Presentations
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Taylor & Francis Ltd Macrophages Cancer Routledge Revivals
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Taylor & Francis Ltd Macrophages Cancer Routledge Revivals
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Taylor & Francis Ltd Understanding Radiation Biology From DNA Damage to Cancer and Radiation Risk
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Taylor & Francis Ltd Understanding Radiation Biology From DNA Damage
Book SynopsisThis book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the doseeffect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and Trade Review“This is a textbook on the understanding of radiation biology, which covers the basic principles governing the action of radiation on living matter. The book is well organized and easy to read. It is designed as an alternative or even complementary to other established books in the fields of radiation biology, radiotherapy, and radiological protection. Moreover, the plethora of mathematical formulas provided makes it easy to translate the presented theoretical concepts into practical tools in the clinic. The contents of the book correlate well with the required topics in preparation for the American Board of Radiology (ABR) board examinations.The most common aspects of radiation biology have successfully been addressed and presented in a way that satisfies the educational and practical goals of the book. The findings of more recent studies have been included. The book also expands to new fields such as ultraviolet light and genotoxicology. The book covers all the necessary theory, examples, and formulas that are useful to radiation biologists, radiation oncology physicians, and medical physicists (professionals and residents). The reference list at the end of the book is a great resource for individuals who want to further expand their literature investigation. This book is primarily designed to cover the needs of radiation biologists, radiation oncology physicians, and medical physicists. It can also be a useful reference for medical dosimetrists and therapy technologists. For faculty and established practitioners, it can serve as a great supplemental resource for dealing with radiation biology problems in the classroom or clinic.The book presents a coherent, quantitative, and qualitative theory of radiation biology, which has been developed and expanded over the years from the 1970s to present. It follows a practical approach providing the mathematical formulas that would allow for an intuitive implementation of the theoretical concepts in the clinic. It can help biologists and radiation oncology and medical physics residents build their background knowledge and understanding of why and how things happen in the clinical environment. Furthermore, it can serve as a quick and comprehensive review of the basic principles and concepts in the field of radiation biology. I recommend this textbook as a teaching tool for biology and medical physics training programs as well as for radiation oncology and medical physics residency programs.”—Panayiotis Mavroidis, PhD (University of North Carolina at Chapel Hill) in Doody’s Core Titles Review 2022.Table of ContentsPART I: Ionising Radiation Effects. 1. The Molecular Model and DNA Double Strand Breaks. 2. The Molecular Model for Cellular Effects. 3. The Link from Molecular Lesion to Cellular Effects. 4. DNA Double Strand Breaks and Chromosomal Aberrations. 5. The Effect of Dose Rate, Fractionation and Post-Irradiation Repair. 6. Radiation Quality. 7. Radiation-Induced Cancer. 8. Radiation-Induced Lethality. 9 Radiological Protection. PART II: Ultraviolet Light Effects. 10. The Molecular Model for the Cytotoxic Action of UV Light. PART III: Genotoxicology. 11. An Assessment of the Risk of Chemical Mutagens.
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