Neurosciences Books

Book SynopsisThis second edition volume expands on the previous edition with new information on the latest developments in the field, and the most up-to-date representative methodological information on molecular neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters in this book are organized into three parts. Part One discusses molecular immunological and pharmacological aspects related to the detection of receptors and ion channels in the brain. Part Two explores the neuroanatomical techniques devoted to localizing receptors and ion channels within the central nervous system. Part Three looks at functional approaches devoted to ascertaining receptors and ion channels functionality in the brain. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and coTable of ContentsSeries Preface…Preface…Table of Contents…Contributing Authors…Part I Molecular Techniques1. Production of High-Quality Antibodies for the Study of Receptors and Ion ChannelsMasahiko Watanabe2. Co-Immunoprecipitation from BrainXavier Morató, Dasiel O. Borroto-Escuela, Kjell Fuxe, Víctor Fernández-Dueñas, and Francisco Ciruela3. Sub-Synaptic Membrane FractionationPaula M. Canas and Rodrigo A. Cunha4. Quantitative Analysis of Cell Surface Expressed, Intracellular, and Internalized Neurotransmitter Receptor Populations in Brain Slices Using Biotinylation Elek Molnár5. Single Nanoparticle Tracking of Surface Ion Channels and Receptors in Brain CellsJuan Varela, Julien Dupuis, François Maingret, and Laurent Groc 6. Radioligand Binding Detection of Receptors in Brain MembranesFuencisla Pilar-Cuéllar, Emilio Garro-Martínez, Elena Castro, and Álvaro Díaz7. Recombinant Alphavirus-Mediated Expression of Ion Channels and Receptors in the BrainMarkus U. Ehrengruber and Kenneth Lundstrom8. Time Resolved-Fluorescence Resonance Energy Transfer using Fluorescent Ligands to Study Native G Protein-Coupled Receptor Heteromerization in Brain Víctor Fernández-Dueñas, Thierry Durroux, and Francisco Ciruela9. Study of GPCR Homo and Heteroreceptor Complexes in Specific Neuronal Cell Populations using the In Situ Proximity Ligation AssayManuel Narváez, Minerva Crespo-Ramírez, Ramón Fores-Pons, Mariana Pita-Rodríguez, Francisco Ciruela, Malgorzata Filip, Sarah Beggiato, Luca Ferraro, Sergio Tanganelli, Patrizia Ambrogini, Miguel Perezde la Mora, Kjell Fuxe, and Dasiel O. Borroto-Escuela10. Amplified Luminescent Proximity Homogeneous Assay (Alpha)-Based Technique to Detect GPCR Oligomers in Human Post-Mortem BrainMarta Valle-León, Víctor Fernández-Dueñas, and Francisco CiruelaPart II Neuroanatomical Techniques11. Fluorescent In Situ Hybridization for Sensitive and Specific Labeling Miwako Yamasaki and Masahiko Watanabe12. Autoradiographic Visualization of G Protein-Coupled Receptors in Brain Rebeca Vidal, Fuencisla Pilar-Cuellar, Álvaro Díaz, and Elena Castro13. Localization of Neurotransmitter Receptor and Ion Channel Proteins in Unfixed Brains using In Situ ImmunoblottingElek Molnár14. Immunohistochemistry for Ion Channels and their Interacting Molecules: Tips for Improving Antibody AccessibilityKohtarou Konno and Masahiko Watanabe15. Localization of GFP-Tagged Proteins at the Electron MicroscopeSara Gil-Perotin, A. Cebrián-Silla, V. Herranz-Pérez, P. García-Belda, S. Gil-García, M. Fil, J.S. Lee, M.V. Nachury, and José Manuel García-Verdugo16. Tyramide Signal Amplificación for Immunoelectron MicroscopyMaría José Ulloa-Navas, Patricia García-Tárraga, Susana González-Granero, Pedro Pérez-Borreda, Vicente Herranz-Pérez, and José Manuel García-Verdugo17. Pre-Embedding Methods for the Localization of Receptors and Ion ChannelsRafael Luján18. Post-Embedding Immunohistochemistry in the Localization of Receptors and Ion ChannelsRafael Luján and Masahiko Watanabe19. High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL)Walter A. Kaufmann, David Kleindienst, Harumi Harada, and Ryuichi Shigemoto20. Pre-Embedding Immunostaining of Brain Tissue and Three-Dimensional Imaging with FIB-SEMMarta Turégano-López, José Rodrigo-Rodríguez, Lidia Alonso-Nanclares, Juncal González-Soriano, Javier DeFelipe, and Ángel Merchán-Pérez21. Application of Virus Vectors for Anterograde Tract-Tracing and Single-Neuron Labeling Studies Hiroyuki Hioki, Hisashi Nakamura, and Takahiro Furuta22. Efficient Labeling of Neurons and Identification of Postsynaptic Sites Using Adeno-Associated Virus VectorMegumu Takahashi, Yoko Ishida, Naoya Kataoka, Kazuhiro Nakamura, and Hiroyuki Hioki23. Analysis of Synaptic Connections at the Electron Microscopic Level using Sindbis Virus Vectors Takahiro Furuta, Keiko Okamoto-Furuta, and Hiroyuki Hioki24. Morphological and Neurochemical Characterization of Electrophysiologically Identified CellsYoshiyuki KubotaPart III Functional Techniques25. Using Electrophysiology to Study Synaptic and Extrasynaptic Ionotropic Receptors in Hippocampal NeuronsIan D. Coombs and David Soto26. Biophysical Methods to Analyze Direct G-Protein Regulation of Neuronal Voltage-Gated Calcium ChannelsNorbert Weiss and Michel De Waard27. Electrophysiological Recordings in Behaving AnimalsAgnès Gruart and José M. Delgado-García28. Voltammetry in Behaving AnimalsKendra D. Bunner and George V. Rebec29. In Vivo Brain Microdialysis of MonoaminesJorge E. Ortega, Blanca Pérez-Palomar, J. Javier Meana, and Luis F. Callado30. Optical Control of Brain Receptors using Photoactive Drug in Behaving AnimalsMarc López-Cano, Víctor Fernández-Dueñas, and Francisco Ciruela31. Dynamic Recording of Membrane Potential from Hippocampal Neurons by Using a Fluorescence Resonance Energy Transfer-Based Voltage Biosensor Víctor Fernández-Dueñas, Xavier Morató, Thomas Knöpfel, and Francisco CiruelaChapter 32. Monitoring GPCR-Mediated cAMP Accumulation in Rat Striatal SynaptosomesJaume Taura, Víctor Fernández-Dueñas, and Francisco Ciruela33. GPCR-Mediated MAPK/ERK Cascade Activation in Mouse Striatal SlicesMaricel Gómez-Soler, Víctor Fernández-Dueñas, and Francisco CiruelaSubject Index List…

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Book SynopsisFrom the best-selling author of Gratitude and On the Move, a final volume of essays that showcase Sacks's broad range of interests—from his passion for ferns, swimming, and horsetails, to his final case histories exploring schizophrenia, dementia, and Alzheimer's.Oliver Sacks, scientist and storyteller, is beloved by readers for his neurological case histories and his fascination and familiarity with human behavior at its most unexpected and unfamiliar. Everything in Its Place is a celebration of Sacks's myriad interests, told with his characteristic compassion and erudition, and in his luminous prose.

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Book SynopsisAll students and researchers of behaviour from those observing freely-behaving animals in the field to those conducting more controlled laboratory studies face the problem of deciding what exactly to measure. Without a scientific framework on which to base them, however, such decisions are often unsystematic and inconsistent. Providing a clear and defined starting point for any behavioural study, this is the first book to make available a set of principles for how to study the organisation of behaviour and, in turn, for how to use those insights to select what to measure. The authors provide enough theory to allow the reader to understand the derivation of the principles, and draw on numerous examples to demonstrate clearly how the principles can be applied. By providing a systematic framework for selecting what behaviour to measure, the book lays the foundations for a more scientific approach for the study of behaviour.Trade Review'Describing what animals actually do in their normal daily activities was deemed essential by the early naturalists and ethologists. Today, many journals actively discourage publishing such research findings. What the Pellis team accomplishes in this book is to document, based on their and others' extensive experience and accomplishments, that careful description can itself be hypothesis driven and answer research questions that experiments with simple, but convenient, dependent measures cannot. This compact guide elegantly shows how to use modern methods to describe and quantify behaviour and embed findings in the behaviour systems in which they occur. From seemingly simple behaviour patterns such as righting, huddling, and reaching, to fighting, foraging, play, and courtship, the authors provide myriad insights and research guidance. Today, in a rapidly changing world, it is more essential than ever to study how the behaviour of animals is being altered, both in natural communities and in experimental laboratories.' Gordon M. Burghardt, University of Tennessee, USA'The Pellis' little book is a big gift box in which you'll find a trove of crafted ideas and handy examples of how behaviour can be analysed in ways that reveal marvellous, unsuspected dimensions of behavioural organisation. Using some of the “simplest” and most common individual and social acts in animal behaviour, they offer observational and analytic tools for seeing the deep structure of behaviour and how, in some cases, their approach can take us into the brain or out to emergent levels of organisation. Practical for students and researchers, and delightful for science-oriented fans of organisms. Put it on your shelf for repeated openings and explorations.' Jeffrey R. Alberts, Indiana University, Bloomington, USA'… a fascinating new way of considering animal behavior … This would be a most useful text for any student or researcher of animal behaviors … Highly recommended.' D. C. Marston, Choice MagazineTable of ContentsPreface; Acknowledgements; 1. What is the problem and what is the solution?; 2. Behaviour as a means, not an end; 3.The deep structure of behavior; 4. The brain is not alone; 5. Bringing it all together: steps in the descriptive process; 6. What of the future?; Epilogue; Appendix A. Eshkol–Wachman movement notation and descriptive analysis; Appendix B. Practice, practice, practice; References; Index.

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Book SynopsisA renowned neurologist shares the true stories of people unable to get a good night's rest in The Nocturnal Brain: Nightmares, Neuroscience, and the Secret World of Sleep, a fascinating exploration of the symptoms and syndromes behind sleep disorders.For Dr. Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleepand their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades c

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Book SynopsisArtist, technologist, and philosopher James Bridle's Ways of Being is a brilliant, searching exploration of different kinds of intelligenceplant, animal, human, artificialand how they transform our understanding of humans' place in the cosmos.What does it mean to be intelligent? Is it something unique to humans or shared with other beingsbeings of flesh, wood, stone, and silicon? The last few years have seen rapid advances in artificial intelligence. But rather than a friend or companion, AI increasingly appears to be something stranger than we ever imagined, an alien invention that threatens to decenter and supplant us.At the same time, we're only just becoming aware of the other intelligences that have been with us all along, even if we've failed to recognize or acknowledge them. These othersthe animals, plants, and natural systems that surround usare slowly revealing their complexity, agency, and knowledge, just as the technologies we've built to sus

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Book SynopsisA.- B.- C.- D.- E.- F.- G.- H.- I.- J.- K.- L.- M.- N.- O.- P.- Q.- R.- S.- T.- U.- V.- W.- X.- Y.- Z.Trade ReviewFrom the reviews:“This reference focuses on a very specific subject--hallucinations and associated sensory and perceptual phenomena. It provides a comprehensive, up-to-date listing of words, terms, concepts, and people associated with its subject. … Entries are arranged alphabetically and are clearly delineated from one another. Each is accompanied with source references, enabling readers to delve more deeply into the topic. … it will be most useful for a highly specialized audience of mental health professionals and scientists. Summing Up: Highly recommended. Researchers/faculty and professionals/practitioners.” (C. L. Mejta, Choice, October, 2010)“Blom, a Dutch clinical psychiatrist who specializes in psychotic disorders and has a Ph.D. in philosophy, aims to reexamine the concepts behind hallucinations from classic psychiatry and incorporate them into current research. … Cross-references are listed throughout the book. … Recommended—this is an original work that will serve as a starting point for health professionals trying to understand various hallucinations. … this book is an appropriate purchase for academic and medical libraries.” (Rebecca Raszewski, Library Journal, September, 2010)“I was pleasantly surprised therefore to find that this is a very solid, workman-like scientific text. … I am very glad to welcome this one. … an extremely well laid out reference book. … The topic is of importance to psychiatrists, neurologists and clinical psychologists. Academic or medical libraries catering for those disciplines can be warmly recommended to consider this for acquisition. … I hope that this adds up to an adequate market for a well-wrought reference book.” (Martin Guha, Reference Reviews, Vol. 25 (1), 2011)“The aim of this dictionary is to make such a body of work more accessible by providing an alphabetical list of key terms and concepts. … Much of what is covered is as one would expect … . would undoubtedly be of interest to anyone curious about the history and nuances of descriptive psychopathology … . I would therefore recommend this book for reference … . It would be a good addition to a reference library … .” (Stephen Ginn, Journal of Mental Health, Vol. 20 (1), February, 2011)Table of ContentsA.- B.- C.- D.- E.- F.- G.- H.- I.- J.- K.- L.- M.- N.- O.- P.- Q.- R.- S.- T.- U.- V.- W.- X.- Y.- Z.

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Book SynopsisEvolution of the Human Brain.- Why the Brain Works the Way it Does: Evolution and Cognition from Movement.- The and.- The.- The.- The and the Evolution of the Cerebral Cortex.- The Cerebral Cortex.- Sings and Symptoms of Neurobehavioral Disorders of Childhood.- Causation from an Evolutionary Perspective.- Therapeutic Theory and Strategy.Table of ContentsEvolution of the Human Brain.- Why the Brain Works the Way it Does: Evolution and Cognition from Movement.- The and.- The.- The.- The and the Evolution of the Cerebral Cortex.- The Cerebral Cortex.- Sings and Symptoms of Neurobehavioral Disorders of Childhood.- Causation from an Evolutionary Perspective.- Therapeutic Theory and Strategy.

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Book SynopsisAn aging population, increasing obesity and more people with mobility impairments are bringing new challenges to the management of routine and emergency people movement in many countries.Table of ContentsPreface.- Dedication.- Pedestrian and Evacuation Dynamics Awards.- Five Grand Challenges in Pedestrian and Evacuation Dynamics.- Data Collection (Evacuation).- Data Collection (Pedestrian).- Data Collection (Vulnerable Groups).- Data Collection (Transport).- Data Collection Methods.- Theory for Models.- General Model Development.- Large-scale Modeling.- Transport Modeling.- Modeling Methods.- Model Calibration / Validation.- Vertical Egress.- Regulations / Engineering Guidance.- Posters

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Book SynopsisContinual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data.Trade ReviewThis is an outstanding book, that fills a real need. Assuming no background in statistics, it covers the data analysis methods neuroscientists need to know, from standard material like hypothesis tests, to specialized methods that have recently found use in our field. It has the detail and insight needed for those developing their own statistical methods. And for the working neurobiologist it has plenty of practical tricks, tips, and examples, coming straight from the experts. This book is a must for anyone serious about quantitative analysis in neuroscience. Kenneth D. Harris, Professor of Quantitative Neuroscience, University College London Analysis of Neural Data is a thorough, authoritative textbook on the fastest growing statistical field. All relevant topics are covered in depth with examples from the literature and thoughtful comments. Particularly welcome is the discussion of multivariate statistics, time series and Bayesian methods, topics frequently encountered in neuroscience research but infrequently discussed in standard statistics textbooks. A highly readable, useful and commendable textbook! Apostolos P. Georgopoulos, Regents Professor of Neuroscience, University of Minnesota This book is a unique and valuable resource for any scientist who wants to approach neural data analysis in a rigorous fashion, or to gain a broad overview of modern statistical concepts and approaches. While the book is an eminently practical guide, it is far from a cookbook. The individual who is willing to invest the time to read it will be deeply rewarded not only with everyday methodological guidance, but also, with a comprehensive understanding of the mathematical foundations of statistics. The first chapter, in which the authors lucidly present a perspective on what statistics has to offer, should be required reading for all neuroscientists - or at least, all who care about data. The authors have met the difficult and competing challenges of creating a book that is both practical and rigorous. To do this, they combine a crisp writing style with a number of helpful strategies, including the use of many carefully-chosen examples from the neuroscience literature, and vivid reminders of the difference between the world of mathematical objects and the world of data. Mathematical concepts that are typically omitted from elementary texts are not avoided, but are discussed in a way that makes their relevance evident...The book is a one-of-a-kind resource that combines practicality, rigor, and accessibility; it is a book that was sorely needed and is an extremely valuable reference. Jonathan D. Victor, Fred Plum Professor, Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medical College Analysis of Neural Data provides an invaluable guide for neuroscientists seeking to summarize and interpret their data. The authors -- leading statisticians who have developed and applied many of the methods they describe themselves - are also outstanding teachers, and the treatment they provide is at once accessible, authoritative, comprehensive, and up-to-date. The book provides a carefully structured introduction to statistical methods for students at the beginning of their research careers as well as a treatment of several advanced methods that will be of value to practicing researchers. James L. McClelland, Lucie Stern Professor in the Social Sciences, Director, Center for Mind, Brain and Computation, Stanford University Written by eminent statisticians, this book covers a range of topics from basic mathematics to state-of-the-art statistical analyses of neural data. Researchers conducting experiments will learn the principles of data analysis and will begin analyzing data using the methods provided. Theoreticians will be introduced to more than 100 intriguing experiments that will teach them to form persuasive interpretations. Analysis of Neural Data should become a standard reference for neuroscience research. Shigeru Shinomoto, Department of Physics, Kyoto UniversityTable of ContentsIntroduction.- Exploring Data.- Probability and Random Variables.- Random Vectors.- Important Probability Distributions.- Sequences of Random Variables.- Estimation and Uncertainty.- Estimation in Theory and Practice.- Uncertainty and the Bootstrap.- Statistical Significance.- General Methods for Testing Hypotheses.- Linear Regression.- Analysis of Variance.- Generalized Regression.- Nonparametric Regression.- Bayesian Methods.- Multivariate Analysis.- Time Series.- Point Processes.- Appendix: Mathematical Background.- Example Index.- Index.- Bibliography.

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Book SynopsisProceedings of a NATO ASI held in Rhodes, Greece, May 12-21, 1996Table of ContentsBiosocial Bases of Violence: Conceptual and Theoretical Issues; A. Raine, et al. Personality and the Biosocial Model of Anti-Social and Criminal Behavior; H.J. Eysenck. A Multidimensional Psychobiological Model of Violence; C.R. Cloninger, et al. Individual Differences and Levels of Antisocial Behavior; M. Rutter. Observational Learning of Violent Behavior: Social and Biosocial Processes; L.R. Huesmann. The Relationship between Low Resting Heart Rate and Violence; D.P. Farrington. Biosocial Bases of Aggressive Behavior in Childhood: Resting Heart Rate, Skin Conductance Orienting, and Physique; A. Raine, et al. Biosocial Risk Factors for Domestic Violence; Continuities with Criminality?; N.S. Jacobson, E.T. Gortner. Emotionality and Violent Behavior in Psychopaths: A Biosocial Analysis; C.J. Patrick, et al. Biosocial Interactions and Violence: A Focus on Perinatal Factors; P.A. Brennan, et al. Unraveling the Social Context of Physique and Delinquency: A New, Long-Term Look at the Gluecks' Classic Study; R.J. Sampson, J.H. Laub. Serotonin and Human Violence: Do Environmental Mediators Exist?; M.J.P. Kruesi, T. Jacobsen. Social Attachment, Brain Function, Aggression, and Violence; G.W. Kraemer. 16 Additional Articles. Index.

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Book SynopsisTrade Review“This book’s abundant appeal and value come from following Berns through the challenges of constructing the experiment and especially of training his dog to participate. ‘Like a catcher and pitcher,’ he writes, he and his dog ‘became a team.’ The satisfaction of that relationship perhaps explains why our two species have lived together so long and happily.” —The Boston Globe “A neuroscientist wonders what goes on in the minds of our pet dogs: Do we delude ourselves when we believe that they love us? [How Dogs Love Us is] a solid introduction to an appealing new area of research.” —Kirkus “The book is as much a scientific exploration of how the canine brain might function as it is a deeply personal story about Berns’s relationship with dogs as pets and colleagues. Ultimately that connection is what makes the book compelling.” —Scientific American MIND “Thoroughly enjoyable and edifying…Five out of five stars…highly recommended.” —Your Dog “In the fascinating book How Dogs Love Us, [Berns] recounts the methods his team employed, and how their pet dogs made these groundbreaking studies possible. There’s much to learn in this engrossing read.” —Bark Magazine “Neuroscientist Gregory Berns studies dog brains to answer that eternal question: Do our dogs really love us?” —Men’s Journal “The journey Berns and his team embarked on, and are continuing, is as remarkable as the study’s conclusions to date. Berns proves what most pet lovers have always known. Our dogs are much like us.” —The Akron Beacon Journal “How Dogs Love Us is a fascinating account of a scientist’s tenacious pursuit of the unknown. Gregory Berns’s account of his lab’s Dog Project provides readers with new insights into the minds of our most loyal companions while also reminding us that scientific research should be approached with passion, love, and a bold disregard for the possibility of failure.” —Dan Ariely, author of The (Honest) Truth About Dishonesty “An exciting journey to the center of a dog’s emotional mind. Berns offers hilarious descriptions of training his dog to lie still while being fed hot dogs in the MRI brain-scan machine.” —Temple Grandin, author of Animals Make Us Human “With infectious passion for dogs, science, life, and love, Gregory Berns takes us on a rollicking yet scientifically serious study of the mental life of dogs-what dogs understand and how they think. Berns’s tale is a dramatic but very funny look at how real, grubby science can accomplish great things. This is dognitive science at its insightful, passionate, and playful best.” —Patricia Churchland, author of Touching a Nerve “How Dogs Love Us is the beautifully written story of an iconoclastic neuroscientist challenging the status quo and seeking to truly understand the dogs with whom we share our lives.” —Jennifer Arnold, author of Through a Dog’s Eyes “Amazingly entertaining and super smart. In How Dogs Love Us, Gregory Berns gives us our first real look inside the brain of a dog, while simultaneously setting new standards in ethical science. A truly great read!” —Steven Kotler, author of A Small Furry Prayer “Gregory Berns’s book, packed with solid scientific research and warm personal stories, will set the agenda for future research on the minds and emotional lives of animals.” —Marc Bekoff, author of The Emotional Lives of Animals “Fast, fun, and funny, Gregory Berns demonstrates scientifically that dogs are people, too.” —Laurence Gonzales, author of Surviving Survival “Gregory Berns’s amusing story about his dogs, his daughters, and a giant magnet communicates as no other what fun science can be.” —Frans de Waal, author of The Bonobo and the Atheist “This book lets you see inside the mind of a dog as never before. How Dogs Love Us will revolutionize how we understand animals—especially our dogs. This is a must-read for animal lovers and neuroscientists alike.” —Brian Hare, author of The Genius of Dogs “Berns is an excellent writer. His explanations of the scientific thinking behind the Dog Project (as he calls his experiment) are crisp and clear and accessible to a nonscientist without being condescending…Some of the best parts of How Dogs Love Us, though, are about the questions, not the answers. In his account of the slow, meticulous, day-to-day process of creating a scientific study, Berns has produced one of the best accounts of how science is ‘done.’” —Chicago Reader “How Dogs Love Us makes a thought-provoking and often humorous case for something canine lovers have suspected for years: dogs are not simply ‘Pavlovian learning machines’ but, rather, sentient beings with a high level of empathy and an affinity for social learning. In answering his original question, he sparks many more about how we value and care for our canine companions.” —Kirsten Galles, Shelf Awareness “Berns’s book is a beautiful story about dogs, love and neurology that shows how nonhuman relationships are inspiring researches to look at animals in new ways, for their benefit and ours.” —Rebecca Skloot, New York Times Book Review

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Book SynopsisVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.Trade ReviewPraise for Previous Editions:"This fine text, by two well-known bioengineering professors at Duke University, is an introduction to electrophysiology aimed at engineering students. Most of its chapters cover basic topics in electrophysiology: the electrical properties of the cell membrane, action potentials, cable theory, the neuromuscular junction, extracellular fields, and cardiac electrophysiology. The authors discuss many topics that are central to biophysics and bioengineering [and] the quantitative methods [they] teach will surely be productive in the future." IEEE Engineering in Medicine and Biology "The authors’ goal in producing this book was to provide an introductory text to electrophysiology, based on a quantitative approach. In attempting to achieve this goal, therefore, the authors have opened the book with a useful, and digestible, introduction to various aspects of the mathematics relevant to this field, including vectors, introduction to Laplace, Gauss’s theorem, and Green’s theorem. This book will be useful for students in medical physics and biomedical engineering wishing to enter the field of electrophysiological investigation. It will also be helpful for biologists and physiologists who wish to understand the mathematical treatment of the processes and signals at the center of the interesting interdisciplinary field." Medical and Biomedical Engineering and ComputingTable of ContentsVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.

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Book SynopsisWhy and how do music and abstract art pack such universal appeal? Why do they often have 'therapeutic' efficacy?Between Couch and Piano links well-established psychoanalytic ideas with historical and neurological theory to help us begin to understand some of the reasons behind music's ubiquity and power. Drawing on new psychoanalytic understanding as well as advances in neuroscience, this book sheds light on the role of the arts as stimulus, and as a key to creative awareness. Subjects covered include:* music in relation to the trauma of loss* music in connection with wholeness and the sense of identity* the ability of music to jump-start normal feelings, motion and identity where these have been seemingly destroyed by neurological disease* the theory of therapeutic efficacy of music and art. Between Couch and Piano is a comprehensive overview that will be of interest to all those intrigued by the interrelation of psychoanalysis and the creative arts.www.psychoanalysisarena.comTrade ReviewBetween Couch and Piano is an enjoyable read, both for its insights correlating psychoanalysis and art - especially music, which the author thinks is inherant to all art - and because of its jargon-free clarity. The book is at once a meditation on the power of music and the summary of a life's work in psychoanalysis. - Donald Kuspit, Professor of Art History and Philosophy, State University of New York at Stony BrookThe developmental scope of his inquiry is no less that cradle-to-grave Dr Rose again reveals himself as both humanist and master clinician. - Stuart Feder, The New York Psychoanalytic Institute and Juilliard, New YorkTable of ContentsKramer, Foreword: A Musician Listens to a Psychoanalyst Listening to Music. Preface. Between Words and Music. On the Shores of Self: Beckett's Molloy (1973). Whence the Feelings From Art: Communication or Concordance? The Music of Time in Faulkner's Light in August (1980). Music as Temporal Prosthesis. In Pursuit of Slow Time: Modern Music and a Clinical Vignette (1987). The Birth of Music in the Context of Loss: Music and Affect Regulation. The Power of Implicit Motion: It Goes Straight Through. A Psychoanalyst Listens to a Musician Listening to Himself Composing. Bibliography.

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Book SynopsisNeurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.Trade ReviewFrom the reviews: “Molecular Mechanisms of Neurotransmitter Release edited by Zhao Wen Wang provides the reader with a comprehensive overview of the complex interactions occurring in pre synaptic neurons involved with chemical communication. … High quality illustrations a large number of which are in full color, support the information in the text … . This book is recommended for the researcher and student of neuroscience … . Neurology residents undergoing specialty training in neuromuscular disease will find this book to be an invaluable resource.” (Joseph Vito Russo, Medical Science Books, April, 2010)Table of Contents1. The Architecture of the Presynaptic Release Site R. Grace Zhai 2. Multiple modes of fusion and retrieval at the calyx of Held synapse Liming He, Benjamin McNeil, and Ling-Gang Wu 3. Roles of SNARE proteins in synaptic vesicle fusion Mark T. Palfreyman and Erik M. Jorgensen 4. Roles and sources of calcium in synaptic exocytosis Zhao-Wen Wang, Bojun Chen, Qian Ge 5. Regulation of presynaptic calcium channels Allen W. Chan and Elise F. Stanley 6. Synaptotagmin: transducing Ca2+-binding to vesicle fusion Carin Loewen and Noreen Reist 7. Functional interactions between the SNARE regulators UNC-13, tomosyn and UNC-18 Robby M. Weimer and Janet E. Richmond 8. Roles of the ELKS/CAST family and SAD kinase in Neurotransmitter Release Toshihisa Ohtsuka and Yoshimi Takai 9. The role of potassium channels in the regulation of neurotransmitter release. Laurence O. Trussell and Michael T. Roberts 10. Modulation of neurotransmitter release and presynaptic plasticity by protein phosphorylation Zu-Hang Sheng 11. Synaptic Vesicle Endocytosis Liesbet Smitz and Patrik Verstreken 12. Lipids and secretory vesicle exocytosis Shona L. Osborne and Frederic A. Meunier 13. Neurotransmitter reuptake and synaptic vesicle refilling Richard J. Reimer*, Kimberly A. Zaia, and Hiroaki Tani 14. Regulation of neurotransmitter release by presynaptic receptors Matthew Frerking, and Joyce Wondolowski 15. Trans-synaptic regulation of presynaptic release machinery in central synapses by cell adhesion molecules Kensuke Futai and Yasunori Hayashi 16. Differential regulation of small clear vesicles and large dense-core vesicles Tao Xu and Pingyong Xu

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