Neurology and clinical neurophysiology Books

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Book SynopsisIntracerebral Hemorrhage offers an up-to-date review of the clinical as well as the biological aspects of this form of stroke. It is aimed at the clinician directing the care of such stroke victims, as well as to the investigator with interest in clinical and experimental research in the field.Trade Review'The three editors, J. Ricardo Carhuapoma, Stephan A. Mayer and Daniel F. Hanley, have clearly succeeded in compiling a standard textbook of high quality (both in writing, tables, images and pictures). It contains all recent publications in the field of spontaneous intracerebral hemorrhage … This is definitely a [highly] recommendable book - it should be on the bookshelf of any neurointensivist dealing with such patients.' E. Schmutzhard, Neurological Intensive Care Unit, Medical University of InnsbruckTable of ContentsPreface; Part I. Epidemiology: 1. The epidemiology of intracerebral hemorrhage Matthew L. Flaherty, Daniel Woo and Joseph P. Broderick; Part II. Etiology of Non-Traumatic Intracerebral Hemorrhage: 2. Acute hypertensive response in intracerebral hemorrhage Ameer E. Hassan, Haralabos Zacharatos and Adnan I. Qureshi; 3. Etiology of tumor-related intracranial hemorrhage Andreas F. Hottinger and Lisa M. DeAngelis; 4. Cerebral amyloid angiopathy Steven M. Greenberg; 5. Coagulopathy-related intracerebral hemorrhage Hagen B. Huttner and Thorsten Steiner; 6. Vascular malformations of the brain Christian Stapf and Jay P. Mohr; 7. Cerebral venous thrombosis and intracerebral hemorrhage Isabelle Crassard and Marie-Germaine Bousser; Part III. Clinical Presentation: 8. Clinical presentation of intracerebral hemorrhage Carlos S. Kase; Part IV. Diagnostic Investigations: 9. Computerized tomography and CT angiography of intracerebral hemorrhage Rush H. Chewning and Kieran P. Murphy; 10. MRI of intracerebral hemorrhage Ken S. Butcher and Stephen M. Davis; 11. Cerebral angiography Ruth H. Chewning and Kieran P. Murphy; 12. Laboratory and other ancillary testing in intracerebral hemorrhage Michael Chen and Louis R. Caplan; Part V. Management and Critical Care: 13. Medical management of intracerebral hemorrhage Neeraj S. Naval, Paul A. Nyquist and J. Ricardo Carhuapoma; 14. Surgical management of intracerebral hemorrhage A. David Mendelow; 15. Future therapy in intracranial hemorrhage and intraventricular hemorrhage: aspiration and thrombolysis Paul Nyquist, Neeraj S. Naval and J. Ricardo Carhuapoma; Part VI. Prognosis and Outcome: 16. Mathematical models of intracerebral hemorrhage and intraventricular hemorrhage outcome prediction: their comparisons, advantages and limitations Stanley Tuhrim; Part VII. Advances in Pathogenesis and Treatment of Intracerebral Hemorrhage - Experimental: 17. Animal models and experimental treatments of intracerebral hemorrhage Kenneth R. Wagner and Mario Zuccarello; 18. Thrombin and secondary neuronal damage following intracerebral hemorrhage Guohua Xi, Richard F. Keep and Julian T. Hoff; 19. Cytoprotection strategies for experimental intracerebral hemorrhage Crystal MacLellan, James Peeling and Frederick Colbourne; Part VIII. Advances in Pathogenesis and Treatment of Intracerebral Hemorrhage - Clinical: 20. Natural history of perihematoma brain odema Manuel Rodriguez-Yáñez, Antoni Dávalos and José Castillo; 21. Hemostasis manipulation for intracerebral hemorrhage Wendy C. Ziai and Stephan A. Mayer; Index.

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Book SynopsisThe compelling account of one man's extraordinary odyssey. Jon Sarkin, an ordinary family man, recovered from a massive stroke to discover that he had become a man possessed with the compulsion to create art.

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Book SynopsisText in French & English. Satellite Symposium of the European Neuroscience Association Proceedings of an International Meeting Held in Marseille (France), 4-7 September 1992 New Vistas on Mechanisms and Control of Emesis.

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Book SynopsisAt the Mariani Foundation meeting held in Milan, October 1995, highly qualified specialists were invited to assist in understanding of the basic principles of cerebral development and brain function, with specific attention to those structures and mechanisms involved in the phenomenon of falls. Epiliptologists illustrate the different semiologic modalities and clinical conditions in which the fall is an essential symptom. A main part of the book is dedicated to the medical and surgical treatment of syndromes where falls appear in the foreground. This volume has the mission of improving life conditions of children who suffer from drop seizures, by limiting the risks to which they are subjected, and to try and compensate for the psychological and social limitations affecting them.

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Book SynopsisThe most important advance in recent epileptology is the recognition of epileptic syndromes and diseases, most of which are well defined and easy to diagnose. The benign childhood partial seizures syndromes exemplify the importance of a precise diagnosis and classification of epilepsies. They are common, and have an excellent prognosis which is better than that of febrile convulsions. Paediatricians and clinical neurophysiologists are now familiar with the Rolandic seizures but are not yet accustomed to diagnosing other benign childhood partial seizures and in particular benign childhood occipital seizures which are often confused with cerebral insults or migraine. The aim of this reference book is to describe the clinical and EEG manifestations of benign childhood partial seizures with particular emphasis on the occipital seizures which are often more characteristic, easier to diagnose and, in some cases, more benign than Rolandic seizures.

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Book SynopsisProvides a comprehensive, literature-based but clinically oriented overview of the pervasive neurological adverse effects that frequently affect those receiving antipsychotic (and pharmacologically related) drugs, giving valuable information to the wide range of healthcare professionals who prescribe and monitor these extensively utilised therapeutic agents.Trade Review'This is an outstanding update of a very instructive book and should be mandatory reading for all trainees in psychiatry residency training programs - as well as their program directors … This book is like finding an oasis in a vast desert.' Doody's ReviewsTable of ContentsPreface; Part I. Setting the Scene: 1. The origins of psychopharma; 2. Some preliminaries; Part II. The Syndromes: 3. Acute dystonias; 4. Parkinsonism; 5. Akathisia; 6. Tardive dyskinesia; Part III. Particular Issues: 7. Tardive and chronic dystonia; 8. Special populations; Part IV. Assessment: 9. The clinical examination; 10. An overview of some standardised recording instruments; Part V. Matters Arising: 11. Involuntary movements and schizophrenia: a limitation to the concept of tardive dyskinesia?; 12. And finally … the salutary tale of 'atypicality'; References; Index.

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Book SynopsisCentral or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases. Neuropathic Pain covers the multitude of causative conditions, as well as epidemiology, clinical diagnosis, prognosis, outcome measurement, evidence-based management, and patient perceptions of individual and general neuropathic pain conditions.Trade Review“…Remarkable in its content and…clarity. The management is evidence based and to the point…the guidance is unambiguous and remarkably straightforward…very useful book for the treatment of patients suffering from neuropathic pain.” - Doody's Review ServiceTable of ContentsPreface; Part I. The Clinical Presentation of Neuropathic Pain: 1. History and physical examination Pam Squire and John Xavier Pereira; 2. Diagnostic testing in chronic neuropathic pain patients Vishal Gupta and Michael Serpell; 3. Epidemiological considerations in neuropathic pain Didier Bouhassira and Nadine Attal; Part II. The Condition of Neuropathic Pain: 4. An overview of animal models for neuropathic pain Patrick L. Stemkowski and Peter A. Smith; 5. Peripheral and central sensitization Cory Toth; 6. Pathophysiology of neuropathic pain: voltage-gated sodium and calcium channels Robyn Flynn and Christophe Altier; 7. Pathophysiology of neuropathic pain: inflammatory mediators Paul J. Austin and Gila Moalem-Taylor; 8. Pathophysiology of neuropathic pain: signaling pathways and their magnification – the role of neuronal toll-like receptors Michael R. Due, Yohance M. Allete and Fletcher A. White; Part III. The Specific Condition: Peripheral Neuropathic Pain: 9. Diabetic and other peripheral neuropathies Cory Toth; 10. Postherpetic neuralgia: the prevention of a scourge C. Peter N. Watson; 11. Painful conditions affecting the nerve roots and plexus Kristine M. Chapman and Amanda Sherwin; Part IV. The Specific Condition: Central Neuropathic Pain: 12. Neuropathic pain following spinal cord injury Jan H. Vranken; 13. Central pain symptoms in multiple sclerosis Scott Jarvis and Bradley J. Kerr; 14. Central post-stroke pain Maan Kattan and Dwight E. Moulin; Part V. The Specific Condition: Other Causes of Neuropathic Pain: 15. The complex regional pain syndromes and post-traumatic neuralgias Anne Louise Oaklander and Steven H. Horowitz; 16. The management of neuropathic pain in cancer patients Wojciech Leppert; 17. Fibromyalgia Mary-Ann Fitzcharles and Peter Ste-Marie; Part VI. The Management of Neuropathic Pain: 18. Antidepressants: TCA and SNRIs Maija Haanpää; 19. Gabapentinoids and other anticonvulsants Howard S. Smith, Charles E. Argoff, Manpreet Kaur and Harsha Nagaraja; 20. Opioids Andrea D. Furlan and Angela Mailis-Gagnon; 21. Cannabinoids Mark A. Ware; 22. Local anesthetics and other interventional approaches Ian Carroll; 23. Spinal cord stimulation and other neuromodulation Krishna Kumar and Syed Rizvi; 24. Drug synergy and therapeutic combinations Stephan A. Schug; 25. The person with pain perspective and participation – an essential component of successfully managing chronic neuropathic pain Lynn Kerene Cooper; Part VII. The Prognosis of Neuropathic Pain: 26. Measuring outcomes in chronic neuropathic pain Nadine Attal; 27. Impact of chronic pain upon anxiety, sleep, and mood dimensions Scott Jarvis and Cory Toth; 28. Impact upon related conditions and quality of life Bharati Vyawahare and John Hughes; 29. The future: new concepts and potential therapies Nicole M. Sumracki, Lauren Nicotra, Yuen Kwok, Liang Liu, Krista van Steeg, Linda R. Watkins and Mark R. Hutchinson; Index.

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Book SynopsisThis comprehensive, multidisciplinary approach to epilepsy compares and contrasts scientific knowledge, clinical experience and social consciousness between Western and non-Western cultures, enhancing transcultural understanding and providing a paradigm for an integrative, truly global health policy for this disorder. Topics covered include pharmacological and non-pharmacological management of epilepsy; care models and traditional medical systems; service organization in resource-limited countries; cultural perspectives on consequences of epilepsy; social, anthropological, economic, political, and spiritual issues related to living with epilepsy; infectious and non-infectious causes and risk-factors; region-specific syndromes. Uniquely drawing attention to both a medical perspective and the burden of living with epilepsy, this is a must-have reference work for epileptologists, neurologists, epidemiologists, medical policymakers and health administrators in both the developed and develoTable of ContentsPart I. Editorial Introduction: 1. Epilepsy: the global burden and transcultural issues; Part II. Infective Causes of Epilepsy: 2. The non-infective causes of epilepsy; 3. Infectious causes of epilepsy: NIMHANS experience and review; 4. Infectious causes of epilepsy: cerebral malaria; 5. Infectious causes of epilepsy: cysticercosis in South America; Part III. Consequences of Epilepsy: 6. Physical consequences of epilepsy; 7. Quality of life and the stigma of epilepsy; 8. Neuropsychiatric consequences of epilepsy; 9. Cognitive consequences of epilepsy: a global perspective; 10. Naming epilepsy: culture-specific perceptions of epilepsy; 11. Knowledge, attitude and practice toward epilepsy; 12. The economic burden of epilepsy in China; Part IV. Comprehensive Epilepsy Care: 13. The clinical approach to investigation and service organization of epilepsy care in low- and middle-income countries; 14. Comprehensive epilepsy care: insights from care models in LAMICS: Latin America; 15. Comprehensive epilepsy care: transcultural issues and the development of a best practice model in India; 16. Comprehensive epilepsy care in China; Part V. The Medical Management of Epilepsy: 17. The medical management of epilepsy: basic principles; 18. The medical management of epilepsy: choice of drugs; 19. The medical management of epilepsy: use of generic drugs; 20. The medical management of epilepsy: antiepileptic drugs and children; 21. The medical management of epilepsy in low- and middle-income countries; 22. The challenge of epilepsy in low-income countries: insights from Laos; 23. Integrated thought: medical management of epilepsy; Part VI. The Surgical Management of Epilepsy: 24. Epilepsy surgery in high-income countries: the example of Great Britain; 25. Models of epilepsy surgery in a large LAMIC: ideal and pragmatic; 26. Models of epilepsy surgery in a large LAMIC: Sree Chitra Tirunal Institute, India; 27. Setting up an epilepsy surgery service in Malaysia; 28. Ideal and pragmatic models of epilepsy surgery in a large LAMIC; 29. Integrated thought: epilepsy surgery; Part VII. Non-Pharmacologic Management of Epilepsy; 30. Non-pharmacologic and psychological management of epilepsy in developed countries; 31. Ayurveda and yoga in the management of epilepsy; 32. Traditional Chinese medicine in the management of epilepsy; 33. Traditional medicine in the management of epilepsy in Ghana; 34. Complementary and alternative medicine in the management of epilepsy: a global perspective; 35. Integrated thought: non-pharmacologic management of epilepsy; Part VIII. Epilepsy Issues with Global Health Impact: 36. The epilepsy treatment gap; 37. Intractable epilepsy: implications with regard to LAMICs; 38. Epilepsy and intellectual disability; 39. Legal implications of epilepsy and epilepsy management; 40. The global campaign against epilepsy; 41. Integrated thought: issues with global health impact; Part IX. International Perspectives: 42. Perspectives on epilepsy in Tibet; 43. Perspectives on epilepsy from Asian-American populations living in the USA; 44. Perspectives on epilepsy in The Lebanon; 45. Perspectives on epilepsy in the Philippines; 46. Integrated thought: international perspectives.

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Book SynopsisUp to 15% of all strokes occur in hospitalized patients, many of whom are there for surgical procedures or cardiac disorders. Outcomes can be poor, with high mortality - possibly related to co-morbidities and the complexities of hospital care. Risk factors for in-hospital stroke include specific operations and procedures (such as cardiac surgery), previous medical disorders (especially a history of stroke or transient ischemic attack), and certain physiological characteristics (including fever and dehydration). More rapid diagnosis and evaluation for interventional therapies is needed. This major new book examines the causes of treatment-related stroke in most hospital-based situations. Therapeutic approaches â including interventional therapies and intra-arterial thrombolysis â are highlighted, including experimental agents and interventions where other treatment possibilities are limited. Increasing the awareness of such interventions is an important factor in reducing delays in the Table of ContentsPart I. Iatrogenic Ischemic Strokes – Peri- and Postoperative Strokes: 1. Stroke after general surgery Magdy Selim and Arne Lindgren; 2. Stroke after open arterial surgery David Bergqvist and Björn Kragsterman; 3. Postoperative stroke in neurosurgery Federico Landriel, Pablo Ajler and Claudio Yampolsky; 4. Vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage Fernando D. Goldenberg, Mario D. Terán and Federico Landriel; 5. Stroke occurring on medical wards David Blacker; 6. Stroke in trauma patients David Blacker; Part II. Iatrogenic Ischemic Strokes – Stroke after Endovascular Procedures: 7. Stroke associated with endovascular procedures Nabeel A. Herial, Mushtaq H. Qureshi and Adnan I. Qureshi; 8. Stroke after diagnostic endovascular procedures Anastasios Mpotsaris and Tommy Andersson; 9. Stroke after endovascular cardiac procedures and cardiothoracic surgery Christian Weimar and Stephan Knipp; 10. Stroke after carotid revascularization procedure Andrei V. Alexandrov, Kristian Barlinn and Robert Mikulik; Part III. Iatrogenic Ischemic Strokes – Other Causes: 11. Radiation therapy and stroke Jelle Demeestere and Vincent Thijs; 12. Stroke after chiropractic manipulations Lars Neeb and Uwe Reuter; 13. Stroke due to air and fat embolism Fernando de M. Cardoso and Gabriel R. de Freitas; 14. Stroke after discontinuation of preventive medications Jelle Demeestere and Vincent Thijs; Part IV. Iatrogenic Hemorrhagic Strokes – Thrombolysis-Related Hemorrhagic Strokes: 15. Intracranial hemorrhage: complication of endovascular therapy for acute stroke Muhib Alam Khan and Rushna Ali; 16. Intracranial hemorrhage: complication of intravenous thrombolysis Norbert Nighoghossian; Part V. Iatrogenic Hemorrhagic Strokes – Intracranial Bleeding: 17. Intracranial hemorrhages secondary to antiplatelet treatment Shraddha Mainali; Part VI. Iatrogenic Hemorrhagic Strokes – Anticoagulation-Related Intracranial Hemorrhage: 18. Intracranial-extracerebral hemorrhage: complication of anticoagulation Muhib Alam Khan; 19. Iatrogenic intracerebral hemorrhage due to oral anticoagulation therapy: risk factors and diagnosis Alexander Tsiskaridze; Part VII. Other Uncommon Causes of Iatrogenic Stroke: 20. Stroke during pregnancy and puerperium Elisabetta Del Zotto and Alessandro Pezzini; 21. Cardioversion-related stroke Morten L. Hansen and Steen Husted; 22. Medication-induced stroke Fazeel M. Siddiqui and Adnan I. Qureshi; Part VIII. Cerebral Venous Thrombosis: 23. Cerebral venous thrombosis José M. Ferro and Patrícia Canhão; Part IX. Medication Reversal and Restarting in Patients with Iatrogenic Strokes: 24. Treatment of oral anticoagulant-related intracranial hemorrhages Mushtaq H. Qureshi, J. Alfredo Caceres and Adnan I. Qureshi.

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Book SynopsisProgressive neurodevelopmental disorders that affect the development of the infant brain can have detrimental impacts on a range of cognitive and emotional behaviors. The identification and management of these disorders can be challenging for neurologists, pediatricians and other healthcare professionals who encounter these conditions in their practices. This book is essential for teaching medical practitioners how to promptly identify neurological regression during childhood development and investigate disorders in sufficient depth to be able to arrive at a precise syndromic diagnosis, plan appropriate management for the patient, and offer advice to caregivers. The text provides a platform for clinicians - new and experienced - to expose their knowledge gaps in the field of neurodegenerative and related disorders. Individual disorders are analyzed by age of onset, with attention given to disorders present in utero, in the newborn, in the infant, and the adolescent, making this a practical and comprehensive guide for any healthcare professional.Table of ContentsPart I. Introduction; Section 1. Introduction; Part II. Rise and Decline of the Child; Section 2. Human Neurological Development; Part III. Mechanisms of Neurological Loss of Function; Section 5. Degeneration in the Central Nervous System; Part IV. Neurodegenerative and Other Progressive Disorders in Childhood; Section 7. Progressive in Utero Disorders; Part V. Regression in Other Neurological and Psychiatric Disorders; Section 12. Epilepsy; Part VI. Induced Regression; Section 21. Loss of Sensory Organs.

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Book SynopsisThe management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending on the site and grade of tumor. Survival rates are improving and care of patients with or recovering from gliomas is increasingly handled in the community under the care of local physicians. This book provides an authoritative, multi-disciplinary summary of glioma biology, genetics, management and social issues, based on the world-leading program at the Duke University Preston Robert Tisch Brain Tumor Center, one of the world''s largest and most successful Centers to offer brain cancer treatment and translational research.The text is written by specialists from this Center, giving it a consistent approach and style. This is an important educational resource for neurologists, neurosurgeons, oncologists, psychiatrists, neurohospitalists and ancillary members of neuro-oncology teams.Table of ContentsPreface; 1. Genetics of glioma Landon J. Hansen, Bill H. Diplas, Joseph Webb, Oren Becher and Hai Yan; 2. Glioma surgery Kyle G. Halvorson and Allan H. Friedman; 3. Radiation therapy for gliomas John P. Kirkpatrick, Grace Kim and John H. Sampson; 4. Chemotherapy for gliomas Annick Desjardins and Henry S. Friedman; 5. Immunotherapy for gliomas Peter E. Fecci, Katherine Riccione, Gavin P. Dunn, Elizabeth Reap, Gordana Vlahovic, Kendra Congdon and John H. Sampson; 6. Neuroradiology of gliomas Peter G. Kranz; 7. Neuropathology of gliomas Roger McLendon and Thomas J. Cummings; 8. Design and statistical analysis of clinical trials for glioma therapy James E. Herndon, II; 9. Health-related quality of life in glioma patients Katherine B. Peters; Index.

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Book SynopsisSymptoms and signs in neurology and psychiatry typically present in the clinical context of other underlying conditions. When evaluating a patient, a physician may choose to review a diverse list of potential underlying diagnoses with the aid of the editor team''s existing text: Neurological Differential Diagnosis: A Case-Based Approach. However, if the patient has a known pre-existing condition, the physician will need to consider a reverse approach - considering what complications of that condition may be associated with current symptoms. This book provides quick-reference, comprehensive, concise summaries of neurologic, psychiatric and medical diagnoses with a focus on neurologic and psychiatric implications of systemic disorders. A separate pharmacology section provides a consolidated review of potential neurologic and psychiatric adverse effects of medications. This book is an invaluable resource for a broad medical audience, from the medical student to the experienced consultant.Table of ContentsList of contributors; Preface; Part I: 1. Entries A–Z; Part II: 2. Medication adverse effects; 3. Cardiovascular and renal medications; 4. Medications to treat diabetes; 5. Hormones and medications to treat endocrine and bone disorders; 6. Gastrointestinal medications; 7. Vitamins and minerals; 8. Medication to treat asthma and allergies; 9. Antimicrobial medications; 10. Antiretroviral medications; 11. Immunosuppressive medications; 12. Oncology and hematology medications; 13. Disease-modifying antirheumatic medications (DMARDs); 14. Medications to treat neurodegenerative diseases; 15. Medications to treat epilepsy; 16. Medications to treat headache and migraine; 17. Medications to treat mental health and substance abuse disorders; Index.

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Book SynopsisDo you find the evaluation of a patient presenting clinical symptoms of distal extremity numbness and weakness daunting and complex? Are you unsure of the diagnostic processes and best-practices in the treatment of peripheral neuropathy? This invaluable guide presents a practical approach to the diagnosis and successful management of patients with peripheral neuropathies. Starting with a structured series of patient queries for symptoms and examination signs, the diagnostic process emphasizes the role of electrodiagnostic tests in defining the neuropathy. Specific neuropathies are presented with their epidemiology, causative pathology, diagnostic and laboratory factors, alongside advised treatments and overall management strategies. This leading resource will assist non-neuromuscular neurologists, physiatrists, neurology and physiatry residents, and will also be useful to electromyographers, proving an ideal aid for busy clinic schedules.Table of ContentsPart I. Approach to the Evaluation of Peripheral Neuropathies: 1. Peripheral nerve anatomy; 2: Peripheral nerve pathology; 3: Clinical approach; 4. Electrodiagnostic evaluation; 5. Diagnostic testing; Part II. Proximal Peripheral Neuropathy: 6. Radiculopathies; 7. Plexopathies; Part III. Mononeuropathies: 8. Median nerve neuropathies; 9. Ulnar nerve neuropathies; 10. Radial nerve neuropathies; 11. Fibular/peroneal nerve neuropathies; 12. Sciatic nerve neuropathies; 13. Femoral nerve neuropathies; 14. Tibial nerve neuropathies; 15. Lateral femoral cutaneous nerve neuropathies; 16. Sural nerve neuropathies; 17. Saphenous nerve neuropathies; Part IV. Acute Immune Neuropathies: 18. Guillain-Barré syndrome: general features; 19. Acute immune demyelinating polyradiculoneuropathy; 20. Acute motor sensory axonal neuropathy; 21. Acute motor axonal neuropathy; 22. Fisher syndrome and Bickerstaff encephalitis; 23. Vasculitic neuropathy; Part V. Chronic Immune Neuropathies: 24. Chronic immune demyelinating polyradiculoneuropathy; 25. Chronic immune demyelinating polyradiculoneuropathy variants and syndromes; 26. Chronic immune-mediated motor and sensory neuropathy with conduction block; Part VI. Length-Dependent Neuropathies: 27. Length-dependent neuropathies: general features; 28. Diabetic neuropathies; 29. Acquired amyloid neuropathies; 30. Neuropathy associated with bariatric surgery; 31. Neuropathy associated with critical illness; 32. Neuropathy associated with environmental toxins; 33. Neuropathy associated with drugs; 34. Neuropathy associated with human immunodeficiency virus; 35. Leprous neuropathy; 36. Neuropathy associated with nutritional deficiencies; 37. Paraneoplastic sensory neuropathy; 38. Small fiber neuropathy; 39. Uremic neuropathy; 40. Neuropathy associated with gluten sensitivity; 41. Neuropathy associated with Lyme neuroborreliosis; Part VII. Hereditary Neuropathies: 42. Hereditary neuropathies (Charcot-Marie-Tooth neuropathies); 43. Neuropathy associated with porphyria; 44. Hereditary amyloid neuropathy; 45. Neuropathy associated Fabry disease; Part VIII. Neuropathies Associated with Rare Conditions and Uncertain Associations: 46: Neuropathies associated with rare conditions and uncertain associations; Part IX. Management of Peripheral Neuropathies: 47. General management; 48. Pharmacologic management.

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Book SynopsisAs the first neurological hospital in the world, founded in 1859, the National Hospital, Queen Square, and its affiliated Institute of Neurology remain leading neurological centres providing exceptional clinical services, teaching and research. Illustrated by over 100 historical images and much unpublished archival material, this book provides a comprehensive history of the National Hospital, the Institute, and their staff. It relates the ups and downs of the Hospital and Institute in war and peacetime, their financial struggles, many personality conflicts, efforts to remain independent and to maintain neurological dominance, academic and clinical contributions, issues relating to specialisation and subspecialisation and relations between disciplines, and the changing roles of the Hospital and Institute. The history is told from varying perspectives against the backdrop of the evolution of British clinical neuroscience, the special position of London medicine, and the influence of worlTrade Review'Shorvon and Compston … have produced a volume of really exceptional quality. … This book, a model of its kind, may become a landmark in the history of hospital medicine in the UK.' Ralph Ross Russell, Brain'The book traces the history of the NHQS since its inception in 1859 until 1997. It was a voluntary hospital until 1948 when the NHS arrived but remained an independent hospital until it joined the University Hospital London NHS Trust in 1996. Readers might be interested to know that the venerable institution came about because of two philanthropic sisters, Johanna and Louisa Chandler and their brother Edward … In short, this is a fascinating, detailed and scholarly read. It is a beautiful book to hold and look through with plenty of photographs. ' Barbara A. Wilson, Neuropsychological Rehabilitation'The book is well illustrated, including the hospital building at various ages including architectural designs, and, of course, the people … The book is recommended highly as a valuable historical reference, but also for some entertaining reading about the history of neurology, many important neurologists, and the interesting place where they worked.' Mark Hallett, World Neurology'This book describes the story of the National Hospital Queen Square and its medical school and the Institute of Neurology during the period of 1859 to 1997 … This book relates the complex history from a number of difference perspectives … I very much enjoyed reading the excellent book and strongly suggest my colleagues and friends to read it too.' Pedro Ruiz, The Journal of Nervous and Mental Disease'… this book is a must-read for anyone who has an interest or background in neurology. The authors and contributors have produced an absorbing clinical, cultural and historical biography of one of the world's great medical institutions-a gargantuan task. The Queen Square lineage indeed remains strong.' Matthew C. Kiernan, Journal of Neurology, Neurosurgery, and Psychiatry'Queen Square is a hospital with a unique history and the authors have succeeded in putting together an engaging volume, in which many neurologists and others interested in the history of medicine and particularly neurology will find material worth reading.' Peter J. Koehler, The Lancet NeurologyTable of ContentsPreface; 1. Foundation and making of the National Hospital; 2. Queen Square, the salmon pink and other hospital buildings; 3. Queen Square and Neurology 1860–1902; 4. National Hospital quadrumvirate; 5. Roller-coaster ride and the National Hospital rubs along: 1902–45; 6. Five dominant National Hospital physicians; 7. NYS arrives and the hospital celebrates its centenary: 1946–65; 8. Beyond the walls: British neurology outside Queen Square; 9. Neurosurgery and war neurology at Queen Square; 10. Other clinical specialties at Queen Square; 11. Neuropathology, neuroradiology and neurophysiology at Queen Square; 12. The Medical School and Institute of Neurology; 13. The rise of academic neurology at Queen Square: 1962–97; 14. Change and integration: 1962–97; Appendix 1. Medical and surgical appointees to the National Hospital and/or Institute of Neurology; Appendix 2. Senior administrative appointees at the National Hospital and/or Institute of Neurology; Appendix 3. Physicians – National Hospital Queen Square 1860–1997.

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Book SynopsisFifty million people worldwide have epilepsy and yet up to 35% of patients experience seizures that are resistant to anti-epileptic drugs. Patients with medication-resistant epilepsy have increased risks of premature death, psychosocial dysfunction and a reduced quality of life. This key resource delivers guidance for all clinicians involved in caring for patients with medication-resistant epilepsy in order to reduce these risks. Covering the epidemiology, biology, causes and potential treatments for medication-resistant epilepsy, this definitive and focused text reviews the clinical care needs of patients. Guidance is practical and includes treatment for specialized groups including pediatric patients and those with psychiatric comorbidities. Several promising non-pharmacologic interventions available for patients, such as surgery, neuromodulation diet therapy and botanical treatment are explored in detail. Leading international figures from a range of disciplines bring their expertise together holistically in this essential manual.Trade Review'This is a wonderful textbook that systematically covers a complex and challenging subset of epilepsy patients. The novelty lies in the fact that there are few textbooks that offer such a comprehensive review - medication resistant epilepsy is often relegated to a single chapter in other comparable textbooks in epilepsy. The book excels in introducing the topic of medication resistant epilepsy (including a functional definition) and offering a detailed review of treatments available.' Mahnoor Rehman, Doody's Book Review ServiceTable of Contents1. The natural history of epilspy Byugin Lee and Sung-Eun Kim; 2. Challenges in identifying medication-resistant epilepsy Martin J. Brodie and Pauls Auce; 3. International league against epilepsy's definition in medication-resistant epilepsy Colin B. Josephson and Samuel Wiebe; 4. The economic impact of medication-resistant epilepsy Charles E. Begley and Shin Jeong; 5. Social consequences of medication-resistant epilepsy Amy Crepeau and Joesph I. Sirven; 6. Morality and morbidity of medication-resistant epilepsy Nuria Lacuey and Samden D. Lhatoo; 7. Models for medication-resistant epilepsy Raman Sankar; 8. Neurobiology of medication-resistant epilepsy Jerome Engel Jr; 9. Genetic causes of medication-resistant epilepsy Thomas N. Ferraro, Bradford D. Fischer and Russel J. Buono; 10. Malformation of cortical development as causes of medication-resistant epilepsy Ruben Kuzniecky; 11. Hippocampal sclerosis as a cause of medication-resistant epilepsy Fahmida Amin Chowdhury, Beate Diehl and Maria Thom; 12. Autoimmune causes of medication-resistant epilepsy Anteneh M. Feyissa and Jeffrey W. Britton; 13. Medication-resistant epilepsy syndromes in children Elia M. Pestana Knight and Elaine Wyllie; 14. Medication-resistant epilepsy in adults Martin Holtkamp and Felix Benninger; 15. Approach to the treatment of medication-resistant epilepsy John Stern; 16. Pharmacotherapy for medication-resistant epilepsy Graham A. Powell and Anththony G. Marson; 17. Reproductive health for women with medication-resistant epilepsy Jiyeon Yoo and Cynthia Harden; 18. Resective medication-resistant epilepsy surgery Barbara C. Jobst and Krzyszof A. Bujarski; 19. Ablative surgery for medication-resistant epilepsy Christian Hoelscher, Kofi-Buaku Atsina, Chengyuan Wu and Ashwini Sharan; 20.1. Vagus and trigeminal nerve stimulation treatment of medication-resistant epilepsy George Nune and Christianne Heck; 20.2. Electrical stimulation of the anterior nucleus of the thalamus for medication-resistant epilepsy Mohamed Z. Koubeissi and Amr Ewida; 20.3. Responsive neurostimulation of the brain for medication-resistant epilepsy Ritu Kapur and Martha J. Morrell; 20.4. Stimulation treatments for medication-resistant epilepsy: transcranial magnetic stimulation Lara M. Schrader; 21. Diet therapy for medication-resistant epilepsy Eric H. Kossoff and Daniel B. Lowenstein; 22. Botanical treatments for medication-resistant epilepsy Steven C. Schachter; 23. Psychiatric comorbidities in medication-resistant epilepsy Andres M. Kanner.

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Book SynopsisElectromyography (EMG) is a technique for evaluating and recording the electrical activity produced by nerves and muscles. Interpreting EMG is a mandatory skill for neurologists and rehabilitation specialists. This textbook provides the reader with a detailed discussion of the concepts and principles underlying electrodiagnostic medicine. It is written for an audience without pre-existing knowledge in this discipline, including beginner technicians and physicians in training. It is an ideal review for seasoned practitioners and those preparing for board examinations. It begins with a review of the foundational sciences and works through the field in twenty chapters, including a large number of case studies demonstrating correct application and interpretation. Appendices of information frequently required in the EMG laboratory, such as Nerve Conduction Study techniques and their age-related normal values, anatomic regions assessed by each NCS and needle EMG studies, safety issues, and oTable of ContentsPart I. Introductory Chapters: 1. Basic electricity and electrical concepts pertinent to EDX medicine; 2. Instrumentation; 3. Anatomy and physiology of neurons; 4. Anatomy and physiology of the neuromuscular junction; 5. Anatomy and physiology of muscle; Part II. Nerve Conduction Studies: 6. Electrodes and nerve conduction study basics; 7. Motor nerve conduction studies; 8. Sensory nerve conduction studies; 9. The NCS manifestations of various pathophysiologies; 10. The utility of NCS for lesion localization and characterization; 11. Late responses and blink reflexes; 12. Repetitive nerve stimulation studies and their manifestations; Part III. Needle EMG: 13. The needle electrode examination (Needle EMG); 14. The Needle EMG manifestations of pathology; 15. Single fiber EMG and macro EMG; Part IV. Other Pertinent Information: 16. Assessment, prognosis, and initial management of peripheral nerve injuries; 17. The EDX Manifestations of Disorders at Various Levels of the Neuraxis; 18. Common pitfalls and their resolution; 19. Safety issues; 20. Nontechnical issues, the patient encounter, and the EDX report; Part V. Case Studies in Electrodiagnostic Medicine: Case 1 through Case X; Part VI. Appendices: Appendix 1. Anatomy of the brachial and lumbosacral plexuses; Appendix 2. Anatomy of the major upper and lower extremity nerves; Appendix 3. The myotomes of the upper and lower extremities; Appendix 4. The SNAP, CMAP, and needle EMG domains of the brachial plexus; Appendix 5. The sensory and motor NCS techniques used in our EMG laboratories; Appendix 6. The age-related, normal control values for the sensory and motor NCS; Appendix 7. Our screening sensory NCS, motor NCS, and needle EMG studies; Appendix 8. The advantages and disadvantages of the EDX test components; Appendix 9. Needle EMG findings with lesions at various levels of the neuraxis.

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Book SynopsisWith the growth of neuropalliative care as a rapidly-emerging subspecialty in neurology, it is essential that clinicians develop core skills to offer high-quality, patient-centred care. This book captures the essence of palliative care in Neurology, highlighting abundant opportunities to incorporate key principles into patients'' management plans. Through a pragmatic, case-based format with suggested references for readers to expand their knowledge on a range of topics, this guide explores didactic opportunities. From patients facing challenging end-of-life decisions, families struggling to determine the treatment intensities, to clinicians leading difficult conversations, these cases are straightforward and relatable. Demonstrating the breadth of palliative care opportunities occurring on the spectrum of neurologic disease, this essential toolkit supports clinicians at all levels, providing assistance for patients who have chronic, progressive, or terminal neurologic diseases. Compelling and thought-provoking, this guide highlights the many opportunities to ease suffering and to improve quality of life.Table of ContentsList of contributors; Section 1. Palliative Care Principles: 1. The role of palliative medicine in neuropalliative care; 2. Common challenges in a palliative medicine consultation; 3. When is the right time to give up?; 4. A request for cognitive enhancement; 5. 'Doctor, how long does he have?'; 6. 'Will I walk again?' Prognostication in spinal cord compression; 7. Prolonged grief following the death of a spouse; 8. Mitigating bereavement risk following a sudden death; 9. 'I'm praying for a miracle'; 10. 'Should his devices be deactivated?'; 11. 'Is it time for hospice?'; Section 2. Cerebrovascular Diseases: 12. Temporary non-invasive ventilation in a do-not-intubate patient; 13. Stroke and end-stage heart failure; 14. Stroke and decompressive hemicraniectomy in a young patient; 15. Surrogate decision-making after a malignant MCA ischemic stroke; 16. A time-limited trial in a case of a basilar artery occlusion; 17. 'Mom never wanted a feeding tube'; 18. Painfully cold, numb, and weak: clinical characteristics and management of central post-stroke pain; 19. Shared decision-making for stroke patients; Section 3. Neurodegenerative and Neuromuscular Diseases: 20. Making a diagnosis with compassion in Parkinson's disease; 21. Caring for patients and families affected by advanced Parkinson's disease; 22. Cognitive decline in Parkinson disease; 23. Evolving goals of care as progressive supranuclear palsy progresses; 24. Psychosis and caregiver strain in Parkinson disease; 25. Constipation and Parkinson disease; 26. Keeping Mom home at the end of life; 27. 'I miss him already'; 28. The dynamic role of palliative medicine throughout the course of neuromuscular disease; 29. Considerations for non-invasive ventilation in neuromuscular disease; 30. Optimizing symptoms before a compassionate wean from the ventilator; 31. The case of a lost patch; 32. Dementia, delirium, and a distended bladder; Section 4. Neuro-Oncology: 33. 'I don't want to be a burden on my family'; 34. Palliative amputation for refractory pain; 35. Chemotherapy-induced peripheral neuropathy; 36. 'Two years may be too far away'; 37. Shifting the goals of care; 38. Management of seizures in patients with glioma from diagnosis through the end of life; 39. The burden of health care surrogacy in the absence of instruction; 40. 'But my brother should be treated'; 41. Taking flight at the end of life; Section 5. Pediatric Neurology: 42. Not another shunt revision; 43. Intrathecal baclofen for severe spasticity; Section 6. Demyelinating Diseases and Autoimmune Neurology: 44. Palliative care in multiple sclerosis: navigating chronic disease can be a difficult pill to swallow at a young age; 45. The perils of late advance care planning in multiple sclerosis; 46. Comparing and contrasting the approach to advance care planning in multiple sclerosis; 47. Comparing and contrasting the approach to advance care planning in multiple sclerosis; 48. Neuropsychological disturbances and fatigue in multiple sclerosis; 49. Pain and psychosocial symptoms in newly diagnosed neuromyelitis optica spectrum disorder (NMOSD); Index.

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Book SynopsisMood disorders such as depression and bipolar disorder are common mental illnesses, affecting millions of patients worldwide. The application of newly available brain imaging methods to the study of mood disorders holds substantial promise in uncovering the brain mechanisms affected in these illnesses. This comprehensive and authoritative text features contributions from leading international experts, providing easily accessible information on the study of the brain mechanisms involved in the causation of mood disorders and the available treatments. Topics covered include the potential of magnetoencephalography (MEG), neuroimaging brain inflammation in depression, electrophysiology studies in mood disorders, and the applications of machine learning, filling an important gap in available neuropsychiatric literature and highlighting new developments. An invaluable resource for practitioners in the fields of psychiatry, neurology, primary care medicine, and related mental health professioTrade Review'Though some chapters are highly technical, the majority can be consumed by an audience with experience reading peer-reviewed biology or psychology journal articles. The book is therefore appropriate for clinicians, researchers, professionals in the health care industry, and students at the graduate and upper undergraduate levels who are interested in mental health … Recommended.' K. Feigenson, CHOICETable of ContentsPreface Sudhakar Selvaraj, Paolo Brambilla and Jair C. Soares; Part I. General: 1. Brain imaging methods in mood disorders Sudhakar Selvaraj, Paolo Brambilla and Jair Soares; Part II. Anatomical Studies: 2. Neuroanatomical findings in unipolar depression and the role of the hippocampus Danilo Arnone; 3. Neuroanatomical findings in bipolar disorder Colm MacDonald and Giulia Tronchin; 4. Neuroimaging biomarkers in pediatric mood disorders Manpreet Singh, Mary Melissa Packer and Whitney Tang; Part III. Functional and Neurochemical Brain Studies: 5. Brain imaging of reward dysfunction in unipolar and bipolar disorders Poornima Kumar, Yueyi Jiang and Alexis E. Whitton; 6. Resting state functional connectivity in unipolar depression Gong QY and Ziqi Chen; 7. Functional connectome in bipolar disorder Amit Anand and Jungwon Cha; 8. Magnetic resonance spectroscopy investigations of bioenergy and mitochondrial function in mood disorders Perry Renshaw and Brent M. Kious; 9. Imaging glutamatergic and GABAergic abnormalities in mood disorders Rodrigo Machado-Viera, Estêvão Scotti-Muzzi, Maria Concepcion Garcia Otaduy and Márcio Gerhardt Soeiro-de-Souza; 10. Neuroimaging brain inflammation in mood disorders Jeffery Meyer; Part IV. Novel Approaches in Brain Imaging: 11. Imaging genetic and epigenetic markers in mood disorders Francesco Benedetti, Sara Poletti, Elena Mazza and Benedetta Vai; 12. FMRI neurofeedback as treatment for depression David Linden and Leon Skottnik; 13. Functional near-infrared spectroscopy studies in mood disorders Koji Matsuo and Toshio Matsubara; 14. Electrophysiological biomarkers for mood disorders Raymond Cho, Nithya Ramakrishnan, Nicholas Murphy and Sudhakar Selvaraj; 15. Magnetoencephalograhy (MEG) studies in mood disorders Allison Nugent; 16. An overview of machine learning applications in mood disorders Benson Mwangi, Natasha Topolski and Su Hyun Jeong; Part V. Therapeutic Applications of Neuroimaging in Mood Disorders: 17. Effects of lithium on brain structure in bipolar disorder Philip Szeszko, Jasmine Kaur and Vivian Kafantaris; 18. Molecular imaging of dopamine and antipsychotics in bipolar disorder Sameer Jauhar; 19. Neuroimaging studies of effects of psychotherapy in depression Prof Philip Cowen, Beata R. Godlewska and Sudhakar Selvaraj; 20. Imaging the effects of psychotherapy in mood disorders Thomas Meyer and Isabelle Bauer.

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Book SynopsisAdvocating a pragmatic and multidisciplinary approach to the management of patients with brain injuries, Traumatic Brain Injury provides a detailed description of care along the whole-patient pathway. Delivering an evidence-based update on the optimal care of both adult and paediatric patients who have sustained injuries ranging from mild to severe, information from on-going multi-centre studies in neurotrauma is included. The basic scientific principles of neuropathology, head injury research and scoring systems are presented before detailed sections on emergency department care, patient transfer, intensive care and longer-term care. Rehabilitation is reviewed in detail with chapters discussing the aims and roles of physiotherapy, occupational therapy and neuropsychology amongst others. Discussing medico-legal issues in detail, the effect of injury on the individual and their family are also examined. Emphasising a holistic approach to caring for patients with brain injuries, this is Trade Review'This book is of good quality, useful for healthcare professionals involved in the care of patients with a traumatic brain injury, and of high value compared to other books in the field due to its broad authorship and multidisciplinary approach.' Amaal Jilani Starling, Doody's Book Review ServiceTable of Contents1. Epidemiology of Head Injury Giles Critchley, Imogen Rogers and Anjum Memon; 2. The Neuropathology of Traumatic Brain Injury David Hilton; 3. Experimental Models of Traumatic Brain Injury Ciaran S. Hill and Hiren C. Patel; 4. Clinical Assessment of the Head Injured Patient Amr H. Mohamed, Peter C. Whitfield and Deva S. Jeyaretna; 5. Neuroimaging in Trauma Won Hyung A. Ryu, Jonathan Coles and Clare N. Gallagher; 6. Scoring Systems for Trauma and Head Injury Antoinette Edwards, Fiona Lecky and Laura White; 7. Early Phase Care of Patients with Mild and Minor Head Injury Anthony Kehoe; 8. Early Phase Care of Patients with Moderate and Severe Head Injury Mark Wilson; 9. Interhosptial Transfer or Brain Injured Patients Thomas Price, Gareth Allen and Robbie Thorpe; 10. Principles of Head Injury Intensive Care Management Martin Smith; 11. Intracranial Pressure Monitoring in Head Injury Adam J Wells, Peter Smielewski, Rikin A. Trivedi and Peter J. Hutchinson; 12. Multimodality Monitoring in Head Injury Tamara Tajsic, Andrew Gvozdanovic, Ivan Timofeev and Peter J. Hutchinson; 13. Therapeutic Options in Neurocritical Care: Optimising Brain Physiology Chiara Robba and Rowan Burnstein; 14. Therapeutic Options in Critical Care – Beyond the Brain Matthew J. C. Thomas and Richard Protheroe; 15. Brain Stem Death and Organ Donation Mark Sair and Martin B. Walker; 16. Anaesthesia for Emergency Neurosurgery Nicola Pilkington and W Hiu Lam; 17. Surgical Issues in the Management of Head-Injured Patients Jane Halliday, Peter C Whitfield and Puneet Plaha; 18. Craniofacial Trauma: Injury Patterns and Management Kathrin J. Whitehouse and Paul McArdle; 19. Cranioplasty after Head Injury Stephen Honeybul; 20. Neurosurgical Complications of Head Injury Ellie Edlmann and Peter C Whitfield; 21. Paediatric Head Injury Management Greg James; 22. Assessment of Capacity and Cognition Maggie Whyte and Fiona Summers; 23. Families: Effective Communication and Facilitating Adjustment Fiona Summers, Helen Gooday, Maggie Whyte and Camilla Herbert; 24. Principles of Rehabilitation Jonathan J. Evans; 25. MDT and Rehabilitation of Head Injury Judith Fewings, Ann-Marie Pringle, Thérèse Lebedis and Maggie Whyte; 26. Neuropsychological Rehabilitation Jonathon J. Evans, Ceri Trevethan, Jackie Hamilton, Bruce Downey, Lindsey Beedie and Emma Hepburn; 27. Assistive Technology and Rehabilitation Brian O'Neill, Catherine Best and Matt Jamieson; 28. Outcomes and Prognosis Helen M. K. Gooday; 29. Medicolegal Aspects of Traumatic Brain and Cervical Spine Injury Peter C. Whitfield and Peter J. Hutchinson.

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Book SynopsisThis book describes the changes in the brain and in cognitive functions that occur with aging in the absence of a neurological, psychiatric, or medical disease. It discusses aging-related changes in many brain functions, including memory, language, sensory perception, motor function, creativity, attention, executive functions, emotions and mood. The neural mechanisms that may account for specific aging-related changes in cognition, perception and behavior are explored, as well as the means by which aging-related cognitive decrements can be managed and possibly ameliorated. Consequently, this book will be of value to clinicians, including neurologists, psychiatrists, geriatricians, primary care physicians, psychologists and speech-language pathologists. In addition, researchers and graduate students who want to learn about the aging brain will find this an indispensable guide.Table of ContentsList of contributors; 1. Introduction Kenneth M. Heilman and Stephen E. Nadeau; 2. Pathology of the aging brain Anthony T. Yachnis; 3. Cellular and molecular mechanisms for age related cognitive decline Jolie D. Barter and Thomas C. Foster; 4. Neuroimaging of the aging brain Ronald. A. Cohen, Eric Porges and Joseph M. Gullat; 5. Changes in visuospatial, visuoperceptual, and navigational ability in aging Gabrielle A. Hromas and Russell M. Bauer; 6. Chemosensory function during neurologically healthy aging Jennifer J. Stamps; 7. Memory changes in the aging brain Glenn J. Larabee; 8. Aging-related alterations in language Stephen E. Nadeau; 9. Changes in emotions and mood with aging Erin Trifilio, John Williamson and Kenneth M. Heilman; 10. Aging and attention Ian H. Robertson and Paul M. Dockree; 11. Changes in motor programming with aging Kenneth M. Heilman; 12. Alterations in executive functions with aging Donald T. Stuss and Fergus I. M. Craik; 13. Brain aging and creativity Ira S. Fischler and Kenneth M. Heilman; 14. Attractor network dynamics, transmitters, and the memory and cognitive changes in aging Edmund T. Rolls; 15. Mechanisms of aging-related cognitive decline Stephen E. Nadeau; 16. The influence of physical exercise on cognitive aging Jamie C. Peven, Chelsea M. Stillman and Kirk I. Erickson; 17. Pharmacological cosmetic neurology Erin C. Conrad and Anjan Chatterjee; 18. Cognitive rehabilitation in healthy aging Nicole D. Anderson and Gordon Winocur; 19. Preventing cognitive decline and dementia Yat-Fung Shea and Steven T. DeKosky.

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Book SynopsisOver 90% of the brain is concerned with higher cortical functions, yet understanding of syndromes, functions, and measurements remains unchartered. This valuable handbook illuminates brain function, natural environment and human function, by delving into the interdisciplinary study. Multifaceted in its perspective, this book demonstrates bi-directionality of information exchange between disciplines. This book weaves around key case reports, series, control studies and cohort studies from cognitive neurology registries, to present the most current, practical research. Gaining appreciation for the fundamental formation and assembly of the supervisory area of the brain will inform an understanding of conditions and behavior for neuroscience professionals, clinical brain scientists and medical students in neuroscience, worldwide. Authored by a leading expert in cognitive neurology, this book guides the reader through the evolutionary, or neuro-archeological, aspects of how the frontal lobeTable of ContentsIntroduction; 1. Progressively larger brains evolved ever since the vertebrate-invertebrate divide; 2. The profound increase in primate gray matter growth; 3. Exponential white matter growth and major fiber tract systems assembly; 4. Cellular and molecular changes; 5. The core frontal systems; 6. Major software upgrading, enhanced working memory (EWM): assembled in Southern Africa during a time of extreme environmental hardship; 7. Unravelling of these networks in neurological conditions – nature's reductionism; 8. Most neurological diseases present as networktopathies with significant diaschisis or remote disconnection phenomena; 9. An exquisitely sensitive prefrontal cortex evolved that is vulnerable to the vicissitudes of daily rhythms; 10. Implications for treatment and management: a network based approach; 11. Sense of self disorders; 12. Implications for you and society.

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Book SynopsisInherited metabolic movement disorders are a significant and rapidly evolving field of study, linking two subspecialty areas of childhood-onset movement disorders and inborn errors of metabolism. Increasing the chance of early recognition of inherited metabolic movement disorders can have significant therapeutic implications for patients. Containing information on new disorders of post-translational modification and autophagy and their identification and treatment, there is thorough coverage of disorders of amino acids, energy metabolism, and lysosomal storage, amongst others. This key resource explores future directions in the field including next-generation genetic sequencing and novel therapeutic approaches such as deep brain stimulation. Supplementary videos are available on Cambridge Core, accessible via the code printed inside the cover. This essential text bridges the gap in communication between experts in genetic-metabolic medicine and movement disorder neurology. With an emphasis on treatable conditions that should not be missed, this volume guides you through various disorders from a clinical, biochemical and genetic perspective.

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Book SynopsisSchizophrenia and other psychoses are common disorders of later life. This book provides a state-of-the-art overview of these disorders, merging relevant scientific knowledge with everyday clinical practice, ensuring that the book will be of great use to researchers, clinicians, and policymakers.Trade Review'This book is a unique compendium of the major studies of aging and schizophrenia. In this way, it provides an essential resource for current understanding of the issues involved. The effort itself involves an important and often neglected area of the mental health field. The book covers the two crucial general areas, the nature of the problem of schizophrenia in later life, and the variety of programs possible for its treatment. … This broad-reaching review reminds care-givers, clinicians, researchers, and community activists of the diversity of 'treatments' that need to be considered and evaluated for more intelligent approaches to care.' John Strauss, Yale University, ConnecticutTable of ContentsPart I. Epidemiology, Historical background, Illness Phenomenology, and Diagnostic Issues: 1. Epidemiology of psychotic disorders: methodological issues and empirical findings Robert Sigström and Deborah Gustafson; 2. Epidemiology of schizophrenia: patterns of care for older adults with schizophrenia Donna McAlpine and Ellen McCreedy; 3. Assessment and diagnosis of psychotic symptoms in older adults Michael Reinhardt, Dina Ghoneim, Tessa Murante, Eric Nelson, Paulina Vargas and Shifra Mincer; 4. A comparison of early and late-onset schizophrenia Dina Ghoneim; Part II. Biological, Neurocognitive, and Medical Aspects: 5. Biological changes in older persons with schizophrenia Michael Centorino and Susan Schultz; 6. Cognitive functioning in older adults with schizophrenia Tarek Rajji; 7. Medical issues in older persons with schizophrenia Frank Copeli and Carl I. Cohen; Part III. Outcome and Course: 8. Assessing outcomes in schizophrenia in later life Carl I. Cohen; 9. Positive psychiatry for schizophrenia and other psychotic disorders Graham Eglit, Barton W. Palmer and Dilip V. Jeste; Part IV. Social Functioning and Mood: 10. Social functioning among older community-dwelling persons with schizophrenia Paul D. Meesters; 11. Depression and suicidality in older adults with schizophrenia John Kasckow and Aninditha Vengassery; 12. Community treatment needs Paul D. Meesters; 13. Treatment of schizophrenia and psychoses in older adults: psychopharmacological approaches Subramoniam Madhusoodanan; 14. Model programs and interventions for older adults with schizophrenia Stephen J. Bartels, Peter R. DiMilia and Heather Leutwyler; 15. Changing caregiver needs with increasing age of people with schizophrenia Harriet P. Lefley and Brian R. Ghezelaiagh; 16. Personal accounts of living with schizophrenia across a lifetime: coping strategies and subjective perspectives Tova Band-Winterstein, Hila Avieli and Peli Mushkin; 17. The care of older adults with schizophrenia in developing countries Rujvi Kamat and Samir T. Mukherjee; Part V. Health Policy and Research: Future Directions: 18. Schizophrenia in later life: public policy issues in the United States Michael B. Friedman, Lisa Furst, Paul S. Nestadt, Kimberly A. Williams and Lina Rodriguez; 19. Epilogue: controversies, conjectures, and future directions Carl I. Cohen and Paul D. Meesters.

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Book SynopsisLarge intracranial lesions are among the most complex and dangerous lesions encountered by neurosurgeons, and a single neurosurgical approach often does not provide a large or safe enough corridor for effective treatment. A combined approach to these surgeries, incorporating open, endoscopic, vascular and keyhole techniques can be more successful. This comprehensive text describes in detail how to select the most appropriate approaches, as well as how to avoid any complications that may arise. High quality videos of the techniques described are available through an online version on Cambridge Core, accessible via the code printed on the inside of the cover. With over 150 colour images supporting the text, this is a definitive reference for anyone involved in intracranial tumor or vascular surgery.

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Book SynopsisStroke is the second leading cause of death and major cause of long-term disability, directly impacting the quality of life, worldwide. Strokes with more rare, and unknown causes unfortunately receive little to no attention due to the heterogeneity of disorders and a poor understanding of clinical features. There are considerable variations in the etiology of this rare sub-category of stroke; requiring heightened clinical awareness for recognition, evaluation and treatment. This book provides up-to-date guidance, through case reports concisely summarised by global leaders in the field describing the diagnosis and treatment of rare causes of stroke, from vasculitis, hypercoagulable states, hereditary and genetic factors, cardioembolism, vasculopathies, venous occlusive conditions to bone disorders. Offering practical advice and algorithms, this book aids the clinician in establishing an accurate diagnosis through detailed evaluation of such patients, leading to an early diagnosis improvTrade Review'… a worthy companion to doctors both inside and outside neurology.' Brendan Huang, Doody's ReviewsTable of Contents1. Inflammatory conditions; 1.1.Isolated vasculitis of the central nervous system; 1.2. Primary systemic vasculitis; 1.2.a. Giant cell vasculitis; 1.2.a.1. Temporal arteritis; 1.2.a.2. Takayasu arteritis; 1.2.b. Necrotising Vasculitis; 1.2.b.1. Polyarteritis Nodosa(PAN); 1.2.b.2. Churg strauss syndrome; 1.2.c. Granulomatosis vasculitis; 1.2.c.1. Wegener granulomatosis; 1.2.c.2. Lymphomatoid granulomatosis; 1.2.d. Vasculitis with prominent eye movement; 1.2.d.1. Susac syndrome; 1.2.d.2. Vogt koyanagi harada disease; 1.2.d.3. Easles disease; 1.2.d.4. Cogan disease; 1.3. Vasculitis secondary to systemic disease; 1.3.a. Systemic lupus erythematosis; 1.3.b. Behçet's disease; 1.3.c. Syögren syndrome; 1.3.d. Sarcoidosis; 1.3.e. Inflammatory bowel disease; 1.3.f. Cerebral amyloid angiopathy related; 2. Infectious and postinfectious vasculitis; 2.1. Meningovascular syphilis; 2.2.Neuroborelliosis; 2.3. Tuberculosis meningitis; 2.4. Bacterial meningitis; 2.5. Neurocysticercosis; 2.6. VZV related: CMV and herpes infections; 2.7. HIV infection; 2.8. Chagas disease; 3. Hypercoagulable causes of stroke; 3.1. Antiphospholipid antibody syndrome; 3.2. Hyperhomocysteinemia; 3.3. Hyperviscosity syndrome; 3.4. Disseminated intravascular coagulopathy and moschkowitz syndrome; 3.5. Henoch schönlein purpura; 3.6. Cancer associated stroke; 4. Drug related stroke; 4.1. Medication related stroke; 4.2. Illicit drug related stroke; 5. Hereditary and genetic causes of stroke; 5.1. Genetic collagen disorders; 5.1.a. Ehlerdanlos syndrome; 5.1.b. Marfan syndrome; 5.1.d. Neurofibromatosis; 5.2. Genetic small vessel disease; 5.2.a. Cerebral autosomal dominant /recessive arteriopathy with subcortical infarcts and leukoencephalopathy-CADASIL and CARASIL; 5.2.b.Retinal vasculopathy with cerebral leukoencephalopathy with systemic manifestations (RVCL-S); 5.3. Genetic metabolic diseases; 5.3.a. Fabry disease; 5.3.b. Mitokondrial diseases; 5.3.c. Menkes disease; 5.3.d. Tangier disease; 5.3.e. Organic acid disorders; 6. Rare causes of cardioembolism; 6.1. Paradoxal embolism: Patent foramen ovale; 6.2. Infective Endocarditis; 7. Vasospastic conditions and other vasculopathies; 7.1. Reversible cerebral vasoconstriction syndrome; 7.2. Eclampsia and stroke during pregnancy and postpartum; 7.3. Migraine and migraine like conditions; 8. Other non-inflammatory vasculopathies; 8.1. Moyamoya disease; 8.2. Cerebral amyloid angiopathy; 8.3. Dolicoectasia and fusiform aneurysms; 8.4. Carotid artery dissection; 9.Venous occlusive conditions; 9.1. Cerebral venous thrombosis; 10.1. Bone disorders and stroke; 10.2. Eagle syndrome.

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Book SynopsisCovering the spectrum of cognitive decline in aging using illustrative cases, from mild impairment to dementia, this set of case studies offers a wide-ranging guide for trainees and clinicians. This second volume includes updated research diagnostic criteria and details of new imaging technology, including novel biomarkers such as PET amyloid and tau, to inform readers in clinical practice. Each case includes a clinical history, examination findings and special investigations, followed by diagnosis and discussion, to encourage clinical reasoning, integrative thinking, and problem-solving skills. To reinforce diagnostic skills, the cases include careful analysis of individual presenting patterns and up-to-date information on diagnostic classification and tools. The reader will be able to distinguish patients who need reassurance, closer follow-up or immediate referral to specialized services. With an international authorship, this book is for trainees and clinicians in neurology, psychiTable of Contents1. A young missionary with problems for quoting the Bible; 2. Care planning and decision making through the stages of dementia; 3. What is typical and atypical in dementia?; 4. Elderly man repeating questions about upcoming appointments; 5. A devoted wife with an atypical finding; 6. A challenging thesis; 7. A 59 year-old dysexecutive clerk; 8. FTD – behavioral variant frontotemporal dementia; 9. A 59 year-old man with weakness and personality changes; 10. A woman with progressive episodic memory loss and personality change; 11. A man with progressive memory loss and a strong family history of progressive dementia; 12. Long day's journey into night: when the pre-symptomatic phase evolves into manifest disease; 13. Right temporal variant frontotemporal dementia; 14. I'm having trouble working with my spreadsheets; 15. Speechless at first sight; 16. De novo artistic talent in a patient with progressive speech problems; 17. From stuttering to mutism: speech and language deterioration in neurodegenerative disease; 18. Primary progressive aphasia: logopenic progressive aphasia; 19. Alexia without agraphia in a patient with pathologically identified Pick's disease; 20. A meaningless world; 21. Obsessive mandala drawing in semantic dementia; 22. Forced into retirement; 23. Who are these people in my living room?; 24. This case of Parkinsonism that never had a good response to Levodopa; 25. Common complaints: rare pathology; 26. Tremor, hallucinations and cognitive decline; 27. Acute behavioral changes with cognitive impairment; 28. Vascular cognitive impairment; 29. Rapidly progressive behavioral changes and cognitive symptoms in a 29-year-old woman; 30. Hashimoto's encephalopathy as treatable dementia; 31. Hydrocephalus and CSF-related dementia; 32. Something very wrong happened very fast; 33. Siblings with a fatal cause of rapidly progressive dementia; 34. Young women with bipolar disorder history.

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Book SynopsisYour brain is shrinking. Does it matter?How Much Brain Do We Really Need? challenges us to think differently about the brain. Rather than just concentrating on the many wonderful things it can do, this entertaining insight into the complexities and contradictions of the human brain asks whether in fact we can live satisfactorily without some of it.The bad news is that our brains start to shrink from our mid-thirties. But the good news is that we still seem to generally muddle along and our brain is able to adapt in extraordinary ways when things going wrong.Alexis Willett and Jennifer Barnett shed light on what the human brain can do - in both optimal and suboptimal conditions - and consider what it can manage without. Through fascinating facts and figures, case studies and hypothetical scenarios, expert interviews and scientific principles, they take us on a journey from the ancient mists of time to the far reaches of the future, via different

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Book SynopsisThis book provides readers with the latest developments in neuroscience research. Chapter One discusses the development of neurochemical characteristics of sensory neurons. Chapter Two reviews current knowledge regarding Mavridis'' area (MA) and its role as a modern stereotactic microanatomic guide for nucleus accumbens (NA) deep brain stimulation (DBS). Chapter Three describes the molecular mechanisms in response to exposure of the central nervous system (CNS) cells to the Ca2+ ionophores to increase the levels of intracellular free Ca2+ and consequently oxidative stress, and it also describes the roles of activation of the Ca2+-dependent proteases and intracellular pathways leading to induction of programmed cell death. Chapter Four reviews clinical features, epidemiology, genetics, physiopathology, management and advanced research on Frontotemporal Dementia and Frontotemporal Lobar Degeneration (FTLD). Chapter Five explores different terpenes and their role in signaling pathway modulating the progression of Alzheimer Disease. Chapter Six discusses the capability of and limitations in PET imaging research on non-human primates for translation to humans for brain aging research as well as therapeutic drug development for neurodegenerative diseases. Chapter Seven studies the imaging markers and prognostic significance of intracerebral hemorrhages (ICH). Chapter Eight reviews clinical practices and surgical intervention for ICH.

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Book SynopsisThe human brain deals, at every instant, with a huge amount of visual stimuli. Besides that, the problem of treating all this information becomes even more complex if we consider that each component of a given stimuli needs to be compared to a set of known signals stored in memory. In Chapter One a numerical solution of Hodgkin Huxley equations is presented to describe the behavior of a neuron and the solution is illustrated by a graphical chart interface to finely tune the behavior of the neuron visually programmed in Java. Chapter Two explores the connection between visual attention algorithms and the recognition of objects by computers in digital images. Chapter Three reviews research and provides original data asserting that bias in legal judgment persists despite the inclusion of visual evidence partly because decision-makers perceptions of visual evidence may be swayed by subjective factors. The preference for a product is usually influenced by the visual appearance of the product image. Chapter Four proposes a new content-based approach, denominated CBAS, that combines textual attributes, visual features and visual attention to compose the products profile. Chapter Five uses electroencephalography (EEG) to investigate the brain activations of visual attention in production designers and analyse the differences between higher creativity (HC) and lower creativity (LC) designers.

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Book SynopsisThis book provides readers with the latest developments in neurosciences research. Chapter One reports on how neural network learning is possible in patients who are not conscious including patients in the vegetative state. Chapter Two is written for educational therapists who are working with ASD cases and the aim is twofold. Firstly, it is to raise the awareness among educational therapists on current neuroscientific studies on the autistic brain and its ASCs (and hence, ASD). Secondly, it is to inform how the findings from these neuroimaging studies can be translated into praxiological implications in autism treatment plan design for educational therapists. Chapter Three studies the postoperative cognitive dysfunction (POCD) in patients after cardiac surgeries along with extensive review of the literature in this field. At least three types of POCD may be outlined, and therefore tests sensitive to each type of POCD should be included into test batteries. Chapter Four discusses the common types of brachial plexus injuries, local anatomy, exam findings, classification systems for injury severity, diagnostic tests and management. Chapter Five integrates the results of prior publications and describes additional findings and further implications providing indications that these intra- and intermuscular sequencing patterns are referenced to the cross-system relevance of efficient movement coordination in general, interlocking the whole range from intersegmental motor interactions down to the functional structures within specific muscles, as one functional entity. Chapter Six reports on strabismus which is the most frequent ocular surgery performed in childhood and requires anaesthesia that provides akinesia, analgesia, and sometimes ocular hypotonia, to adjust sutures. Chapter Seven studies the poster dorsal medial amygdala (MePD) which is involved in the display of reproductive behaviour in both male and female rats. Further studies demonstrated that it also integrates a subcortical social behaviour network with additional, but selective modulatory roles.

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Book SynopsisThis book provides readers with the latest developments in neurosciences research. Chapter One summarized the progress of this area over the past two decades by showing that inflammatory mediators (ligands in a positive feedback loop and/or other inflammatory mediators through receptor cross-talk) released from inflamed or injured tissues increase cell surface trafficking of nociceptive receptors in primary sensory neurons and dorsal horn neurons. The aim of Chapter Two is to discuss and detail well-established stress animal models, discussing their validity to mimic human neuropsychiatric disorders (i.e. depression, anxiety and cognitive deficiency). Chapter Three discusses post-dural puncture headache (PPH) which is the most common major complication following neuraxial anaesthesia and usually happens in obstetrics. Chapter Four reviews the known pharmacological mechanisms of action of first- and second-generation synthetic cathinones in the central nervous system in comparison to those of cocaine and amphetamines. These studies of the efficacy of Cognitive Behaviour Therapy in adults with ADHD are reviewed in Chapter Five. As reported in Chapter Six, adult hippocampal neurogenesis is mediated by many factors and plays an important role in several diseases, such as Alzheimer disease, stroke, depression and epilepsy. In Chapter Seven, cognitive maps characteristics and the brain systems involved in spatial navigation of cognitive maps are the main focus. Chapter Eight reports on the improvement of human cognition and its precision due to technological advancement within the field of neuroscience. Chapter Nine demonstrates that low concentrations of N-acyl dopamines (below 1 am) stimulate cell proliferation, intermediate ones (1-20 gm.) induce differentiation, and higher ones lead to apoptosis.

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Book SynopsisIn chapter one, Zhenggang Xiong and Liqiong Liu discuss their perception of the genetic alterations of gliomas and the biomarkers that can be used for classification, individualised treatment, and predicting prognosis of gliomas. Next, Norma Angélica Moy-López, Nadia Yanet Cortés-Álvarez, César Rubén Vuelvas-Olmos, María Fernanda Pinto-González, Jorge Guzmán-Muñiz, Jorge Luis Collás-Aguilar and Oscar P. Gonzalez-Perez concentrate on the effect of exposure to maternal HFD and obesity on offspring neurodevelopment in chapter two. In chapter three, Alan J. Pearce abridges current studies engaging techniques such as electroencephalography (EEG), magnetoencephalography (MEG), and transcranial magnetic stimulation (TMS). Pierce addresses the advantages of using these techniques and how these techniques can be employed. In chapter four, Rocio Gomez-Herreros, Isabel Melguizo-Moya, M. Esther Sanchez-Garcia, and M. Asuncion Navarro-Puerto review dementia with Lewy bodies together with the diagnostic approach. Isabel Melguizo-Moya, M. Asunción Navarro-Puerto, Rocío Gómez-Herreros, and M. Esther Sánchez-García discuss late-onset systemic lupus erythematosus and the importance of an altered therapeutic approach in chapter five. After, brain mapping, intra-operative advanced cortical and subcortical mapping, and mapping stimulation protocols currently in use in the Department of Neurosurgery and Neuro-oncology at Kings College Hospital are presented by Christian Brogna, MD, PhD, Noemia Pereira, Eduardo C. Ribas, MD, PhD, Holly Jones, Francesco Vergani, MD, PhD, Sanjeev Bassi, Keyoumars Ashkan, and Ranjeev Bhangoo. In chapter seven, María de la Luz Arenas-Sordo, MD, PhD, Carlos P. Viñals-Labañino, MD, Laura L. Flores-García, MD, and Elsa Alvarado Solorio, MD present findings from a study group at the Pediatric Rehabilitation Department of the Instituto Nacional de Rehabilitacion. Moving on, chapter eight by M. Esther Sanchez-Garcia, M. Asuncion Navarro-Puerto, Isabel Melguizo-Moya, and Rocio Gomez-Herreros discusses Primary Sjögren''s syndrome (pSS) and the neurological complications that may arise from it. Synji De Paula Mulatiere, M Eugenia Gutiérrez Marco, Carmen Moret-Tatay, and M José Beneyto Arrojo wrap up the book with a discussion of the concept of resilience in chapter nine.

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Book Synopsis

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Book Synopsis

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Book SynopsisMultiple Sclerosis is one of the most common neurological disorders leading to disability. Many cases of Multiple Sclerosis are diagnosed late especially in young patients because providers are not considering it early in their assessment and differential diagnosis. This book will provide an additional resource to health care providers working with children and adolescents to facilitate increased awareness and earlier diagnosis and treatment.

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