Neurology and clinical neurophysiology Books

Book SynopsisWritten for all health professionals working with people with dementia, Physical Comorbidities of Dementia describes the common physical conditions occurring in people with dementia. Many of these conditions are treatable and this book provides evidence-based recommendations on how to recognise and manage these conditions and improve quality of life.Trade Review'Any health professional working with PWD ought to have access to a copy of this useful little tome, and I think I will be a better doctor to my patients for having read it.' International PsychogeriatricsTable of ContentsAcknowledgements; Foreword; Preface; 1. Introduction; 2. Falls; 3. Delirium; 4. Epilepsy; 5. Weight loss and nutritional disorders; 6. Incontinence; 7. Sleep disorders; 8. Visual dysfunction; 9. Oral disease; 10. Frailty; Index.

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Book SynopsisThe Handbook of ECT covers all aspects of contemporary electroconvulsive therapy (ECT) practice. This concise yet informed text provides medical practitioners with both the theoretical background and practical knowledge to guide them in the practice of ECT. The text is filled with ''clinical pearls'' from an expert practitioner which will be of great use to both new and seasoned practitioners of ECT. Each chapter is comprehensively referenced with the latest ECT research and clinical literature. Topics covered include research on mechanisms of action, patient selection by diagnosis, pre-procedural medical and laboratory evaluation, patient preparation in the ECT suite, stimulus dosing strategies, ECT anesthesia, clinical decision making and continuation/maintenance treatment strategies. This book will be of particular value for practicing psychiatrists, psychiatric residents and medical students rotating in psychiatry.Table of ContentsPreface; Abbreviations; 1. Basic concepts of ECT; 2. Patient selection and preparation for ECT; 3. ECT technique; 4. ECT treatment course; 5. Common adverse effects; 6. The ECT service; 7. Special issues.

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Book SynopsisThis essential and concise clinical reference guide serves diverse clinicians and allied health professionals who prescribe antiepileptic drugs in contemporary clinical practice. Fully updated, it features chapters on newly-approved drug brivaracetam, updated paediatric prescribing, use in particular populations including women, the elderly, and patients with cognitive impairment, as well as sections on teratogenicity, pregnancy, and lactation. In full colour throughout, the guide provides comprehensive antiepileptic drug (AED) prescribing information, covering all thirty-five AEDs in alphabetical order. Each chapter features eight coloured sections including general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special population considerations, a summary overview, and suggested reading. Perfect for quick reference use, the guide is practical and essential for all AED drug prescribers including adult and paediatric neurologists, neurosurgeons, pTable of Contents1. Acetazolamide; 2. ACTH; 3. Brivaracetam; 4. Carbamazepine; 5. Clobazam; 6. Clonazepam; 7. Diazepam; 8. Eslicarbazepine; 9. Ethosuximide; 10. Felbamate; 11. Fosphenytoin; 12. Gabapentin; 13. Lacosamide; 14. Lamotrigine; 15. Levetiracetam; 16. Lorazepam; 17. Methsuximide; 18. Midazolam; 19. Oxcarbazepine; 20. Paraldehyde; 21. Perampanel; 22. Phenobarbital; 23. Phenytoin; 24. Piracetam; 25. Pregabalin; 26. Primidone; 27. Rufinamide; 28. Stiripentol; 29. Sulthiame; 30. Tiagabine; 31. Topiramate; 32. Valproate; 33. Vigabatrin; 34. Zonasimide.

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Book SynopsisFor neurodegenerative diseases such as Parkinson's and Alzheimer's there is no unifying biology, explaining why every attempt to cure them has failed. This book provides a blueprint for a new way of thinking, eliminating misleading diagnostic labels and enabling the development of effective therapies, one biological subtype at a time.Trade Review'This book attempts to incorporate overarching scientific themes with a detailed overview of pathophysiology and clinical features of Parkinson's disease. The chapters examine clinical features, subtypes and progression of the disease, ways of looking at the disease scientifically, a comparison to oncology, and a review of disease modifying treatments versus symptomatic treatment. The diagrams and tables are outstanding and the production values are excellent. The book, however, is limited by the attempt to tackle big concepts for a more lay public with very technical writing, an unimaginative look at theory and facts, and the distinctly different styles between the two authors.' Rohit Das, Doody's Book Review ServiceTable of ContentsPreface; Acknowledgements; 1. The shaky six and the 'second reality'; 2. Pieces of a puzzle?; 3. Disease 'redefinition': a tough pill to swallow; 4. Disease subtypes: the promise and the fallacy; 5. Protein paradox; 6. The fault in our models; 7. Biomarkers: the promise and the fallacy; 8. Lessons from oncology; 9. Symptomatic vs. disease-modifying therapies; 10. The hypothesis that refuses to die; 11. Our living dissonance; 12. The scientific and lay narratives; 13. Challenges viewed from afar; 14. The moonshot: population-based studies of aging; 15. Predictions for the 2020s and beyond; Epilogue. 'When will we have a cure for Parkinson's disease?”; Note added at press time; References; Index.

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Book SynopsisThe fourth edition of this popular Handbook provides the latest guidance on prescribing and administering electroconvulsive therapy (ECT). Leading researchers and practitioners review new research on ECT and related treatments, including their efficacy in children and adolescents, and in those with bipolar disorder and neurological conditions. With a focus on safe provision and minimisation of side effects, it provides the reader with practical, evidence-based advice. The book has been substantially revised: references have been updated throughout; related treatment modalities such as rTMS, tCDS and ketamine are covered in greater depth; and current administrative and legal framework guidelines are clearly outlined. An essential reference manual for consultant and trainee clinical psychiatrists, as well as ECT practitioners. This guide will benefit clinical teams looking after complex cases of depression, as well as those involved in the care of other people for whom ECT may be recommended.

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Book SynopsisTable of ContentsSection 1. Setting the Scene: The Spectrum of Spinal Injury 1. Causes of spinal injury: motor vehicle accidents and beyond 2. Global aspects of traumatic spinal injury 3. Economics of traumatic spinal injury 4. Spinal cord injury and the risk of dying Section 2. Cellular and Molecular Aspects 5. Spectrum of syndromes in spinal injury Central cord syndrome and beyond 6. Neuroinflammation in spinal cord injury 7. Spinal cord injury and cellular excitotoxicity 8. Cytokines and spinal cord injury 9. Cells and spinal cord injury: a focus on glial cells 10. Regenerative response of after spinal injury: propriospinal neurons and beyond 11. Astrocytes in spinal cord injury 12. Linking spinal cord injury and remodeling of the enteric neuromuscular compartment 13. Leukocyte gene expression and spinal cord injury 14. Angiotensin-(1-7) receptor Mas and spinal cord injury 15. Coenzyme Q10, Bax/Bcl2 and Spinal cord injury 16. Signalling pathways in spinal cord injury: a focus on ERK and AKT 17. Wnt signaling in spinal cord injury 18. Gene expression and spinal cord injury: a focus on the motor cortex 19. Glucose metabolism and gene expression in spinal cord injury 20. Receptors in spinal cord injury: a focus on glutamatergic and glycinergic receptors 21. Ion channel and receptors: gene expression and in spinal cord injury Section 3. Physiological and Metabolic Effects 22. Hormonal events and spinal cord injury: a focus on vasopressin and natriuretic peptide 23. Linking sensorimotor plasticity, the motor cortex and spinal cord injury 24. Spinal cord injury-induced spasticity 25. Effects of spinal cord injury: Cerebral perfusion and autonomic cerebrovascular control 26. Skeletal muscle atrophy in spinal cord injury 27. Bone mass and spinal cord injury: risk of fracture Section 4. Behavioural and Psychological Effects 28. PTSD and spinal injury 29. Health behaviors after spinal cord injury: alcohol use and beyond 30. Oxidative stress in spinal cord injury 31. Features of endoplasmic reticulum stress: applications to spinal cord injury 32. Health behaviors, people with spinal cord injury 33. Quality of life in cervical traumatic spinal cord injury 34. Empathy in spinal cord injury 35. Daily living measures in spinal cord injury

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Book SynopsisTable of ContentsSection 1. Setting the Scene: Introductory Chapters 1. Epidemiology of traumatic spinal injury 2. Subgroup analyses in spinal cord injury 3. Long-term mortality, traumatic cervical spine fracture 4. Spinal cord injury: the role of functional rehabilitation Section 2. Clinical Features of Spinal Cord Injury 5. Physical signs and symptoms of spinal cord injury 6. Psychological signs in spinal cord injury 7. Bowel and bladder control in spinal cord injury 8. Pressure injuries in spinal cord injury 9. Tetraplegia and paraplegia after cervical spinal cord injury Section 3. Diagnosis and Evaluation 10. The Canadian C-Spine Rule in emergencies 11. The American College of Radiology and criteria for suspected spine injuries 12. Biomarkers in spinal cord injury 13. Cardiovascular monitor ring and spinal cord injury: Blood pressure and beyond 14. Pain and its evaluation in spinal cord injury 15. Quality of life tools for spinal cord injury 16. Magnetic resonance imaging usage in spinal cord injury: in tracheostomy and beyond 17. Assessments in spinal cord injury: indices of neurological impairment Section 4. Treatments: Experimental and Clinical 18. Clinical management of acute spinal cord injury 19. Reducing the catastrophic spinal cord injuries in head impacts: helmet-mounted devices and beyond 20. Stem cells and chronic spinal cord injury: overview 21. Gene therapy in spinal cord injury 22. Spinal injury, brain-triggered electrical stimulation and visual feedback 23. Spinal cord stimulation to reduce pain 24. Short-term resistance training, muscles strength and in people with spinal cord injury 25. Treating sleep problems in spinal cord injury 26. Exercise programs in spinal cord injury 27. Drug delivery in spinal cord injury: Delivery of neuroprotective minocycline 28. Spinal cord, acrolein and usage in ischemic-reperfusion injury 29. Alpha 2delta ligands for pain relief in spinal cord injury 30. Cognitive behavioural therapy in spinal cord injury: pain and beyond Section 5. Rehabilitation in Spinal Cord Injury 31. Best practice in spinal cord injury (Spinal Cord Injury (SCI) ) rehabilitation 32. Depressive symptoms in rehabilitation, spinal cord injury 33. Rehabilitation and wheelchair users 34. Rehabilitation with activity-based therapy 35. Spinal cord injury rehabilitation and pressure injury

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Book SynopsisTable of ContentsSection 1. Setting the Scene: Introductory Chapters 1. Classification of traumatic brain injury 2. Traumatic Brain injury: what happens after 2-3 years 3. Traumatic Brain injury: what happens after 21 years 4. Recovery after traumatic brain injury in childhood: on line skill training for parents Section 2. Clinical Features of Traumatic Brain Injury 5. Features of neuroinflammation: what happens in traumatic brain injury 6. Cerebral blood flow and traumatic brain injury 7. Brain hemorrhages in traumatic brain injury 8. Pain, traumatic brain injury and consciousness 9. Vascular in traumatic brain injury 10. Loss of consciousness in traumatic brain injury 11. Amnesia and traumatic brain injury 12. Axonal injuries in traumatic brain injury 13. Regional damage: The orbitofrontal cortex in traumatic brain injury 14. Epilepsy and traumatic brain injury Section 3. Diagnosis and Evaluation 15. Using electroencephalography for classifications in traumatic brain injury 16. Concussion classification and traumatic brain injury 17. Using the Glasgow Coma Scale in traumatic brain injury 18. Biomarkers of adult traumatic brain injury 19. Brain swelling in traumatic brain injury 20. Electroencephalography and traumatic brain injury 21. White matter in traumatic brain injury 22. Web-based decision support system (DSS), and prediction of outcomes and traumatic brain injury 23. Use of three-dimensional time-of-flight (TOF) magnetic resonance angiography (MRA) traumatic brain injury 24. High-definition fiber tracking in traumatic brain injury 25. Use of diffusion tensor imaging in traumatic brain injury Section 4. Treatments: Experimental and Clinical 26. The Brain Trauma Foundation (BTF) guidelines 27. Healthy lifestyle programs for traumatic brain injury subjects 28. Hyperbaric oxygen therapy and traumatic brain injury 29. Bumetanide medication: depression and brain trauma 30. NLRP3 inflammasome inhibitors and usage in traumatic brain injury 31. Fever and management in traumatic brain injury 32. Mannitol usage in traumatic brain injury 33. Seizures after traumatic brain injury 34. Hypertonic saline usage and traumatic brain injury 35. Treating venous thromboembolism in traumatic brain injury 36. Critical care management of traumatic brain injury Section 5. Rehabilitation in traumatic brain injury 37. Guideline for traumatic brain injury rehabilitation in adults 38. Guideline for traumatic brain injury rehabilitation in children 39. Outcomes of extended rehabilitation programmes 40. Rehabilitation of cognition after traumatic brain injury 41. Sexuality and rehabilitation after traumatic brain injury

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Book SynopsisAuthor of the viral Medium piece, Poor and Traumatized at Harvard, Due Quach shares her Calm Clarity program to show readers how to deal with toxic stress and adversity.We often don't realize how much control we have over our thoughts, feelings, and actions--on some days, the most minor irritation can upset us, but on others, we are in our best form and can rise to challenges with grace. These fluctuations depend on the neural networks firing in our brains, and we have the power to consciously break hardwired thought patterns. Due Quach developed an intimate understanding of the brain during her personal journey of healing from post-traumatic stress disorder.     According to Quach, people function in three primary emotional states: Brain 1.0, Brain 2.0, and Brain 3.0. In Brain 1.0, people act out of fear and self-preservation. Brain 2.0 involves instant gratification and chasing short-term rewards at the expense of long-term well-being. Brain 3.0

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Book SynopsisAn argument that health is optimal responsiveness and is often best treated at the system level.Medical education centers on the venerable “no-fault” concept of homeostasis, whereby local mechanisms impose constancy by correcting errors, and the brain serves mainly for emergencies. Yet, it turns out that most parameters are not constant; moreover, despite the importance of local mechanisms, the brain is definitely in charge. In this book, the eminent neuroscientist Peter Sterling describes a broader concept: allostasis (coined by Sterling and Joseph Eyer in the 1980s), whereby the brain anticipates needs and efficiently mobilizes supplies to prevent errors.Allostasis evolved early, Sterling explains, to optimize energy efficiency, relying heavily on brain circuits that deliver a brief reward for each positive surprise. Modern life so reduces the opportunities for surprise that we are driven to seek it in consumption: bigger burgers, more opioi

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Book SynopsisA scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease.Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries.Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developme

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Book SynopsisHow do our brains store—and then conjure up—past experiences to make us who we are?Trade Review"[A] roving, riverine inquiry into memory, experience, the brain…O'Keane does not try to dazzle us with interpretations and cures, but dazzle she does with the science, the clarity with which she can conjure something as ordinary, as bafflingly complex and beautiful, as a memory forming in the brain." -- Parul Sehgal, The New York Times"These passages are vivid and immediate, and all the more affecting for the measured and unemphatic manner in which they are set down. If O’Keane is as fine a doctor as she is a prose stylist, her patients are fortunate indeed." -- John Banville, Guardian"[O'Keane's] unforgettable trip down memory’s many lanes leaves you with a marvelling awareness of what humans collectively share as memory makers and, at the same time, reminds us that each one of us is a singular translator of our world." -- London Observer"Rich, revelatory and, in the best way, unsettling." -- London Sunday Times"A comprehensive tour of the current state of knowledge about how memory operates in the brain." -- Elizabeth Landau, Undark"[O'Keane] delivers interesting observations on nearly every page…A welcome new voice in the literature of consciousness and neuroscience." -- Kirkus Reviews"O'Keane offers no shortage of intriguing insights and accounts…[A]n immersive and informative look at how memory works, and what happens when it doesn't." -- Publishers Weekly"Wonderful. I love the way Veronica O’Keane writes…difficult concepts made comprehensible with rich case studies. A must read for every counselor, psychotherapist, life coach and psychiatrist." -- Philippa Perry, author of The Book You Wish Your Parents Had Read"Veronica O’Keane distills what she has learned about people in her life as a psychiatrist and neuroscientist. The reader will appreciate Dr. O’Keane’s beautiful prose and her caring attitudes, and will effortlessly pick up knowledge about how the brain determines our behavior." -- Robin Murray, professor of psychiatric research, King’s College, London

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Book SynopsisThis book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.Table of ContentsPREFACE. CONTRIBUTORS. I MODELS, APPROACHES, AND CHALLENGES IN NEUROTOXICITY RESEARCH DURING DEVELOPMENT (Tucker A. Patterson). 1 APPROACHES AND MODELS FOR EVALUATING THE TOXIC EFFECTS OF ANESTHETICS IN THE DEVELOPING NERVOUS SYSTEM (William Slikker, Jr., Xuan Zhang, Fang Liu, Merle G. Paule, and Cheng Wang). 2 SYSTEMS BIOLOGY APPROACHES TO NEUROTOXICITY STUDIES DURING DEVELOPMENT (Tucker A. Patterson, Bradley J. Schnackenberg, William Slikker, Jr., and Cheng Wang). 3 BEHAVIORAL APPROACHES FOR ASSESSING NERVOUS SYSTEM FUNCTION DURING DEVELOPMENT IN ANIMAL MODELS (Merle G. Paule). 4 APPLICATIONS OF UNBIASED STEREOLOGY TO NEURODEVELOPMENTAL TOXICOLOGY (Peter R. Mouton). II EFFECTS OF ANESTHETICS AND THEIR POTENTIAL NEUROTOXICITY DURING DEVELOPMENT (Xuan Zhang and William Slikker, Jr.). 5 NEUROTOXIC EFFECTS OF ANESTHETICS AND POTENTIAL PROTECTIVE AGENTS (Xuan Zhang, Tucker A. Patterson, Merle G. Paule, William Slikker, Jr., and Cheng Wang). 6 PERINATAL RHESUS MONKEY MODELS AND ANESTHETIC-INDUCED NEURONAL CELL DEATH (William Slikker, Jr., Fang Liu, Xuan Zhang, Xiaoju Zou, Tucker A. Patterson, Merle G. Paule and Cheng Wang). 7 EFFECTS OF GASEOUS ANESTHETIC COMBINATIONS DURING DEVELOPMENT (Vesna Jevtovic-Todorovic). 8 PERINATAL ANESTHETIC ADMINISTRATION AND SHORT/ LONG-TERM BEHAVIORAL DEFICITS (Vesna Jevtovic-Todorovic). III THE DEVELOPMENTAL BASIS OF ADOLESCENT OR ADULT DISEASE (Jerrold J. Heindel). 9 DEVELOPMENTAL LEAD EXPOSURE, EPIGENTICS AND LATE ONSET ALZHEIMER'S DISEASE (Nasser H. Zawia and Md. Riyaz Basha). 10 DEVELOPMENTAL TRAJECTORIES OF AUTISM AND ENVIRONMENTAL EXPOSURES—WHAT WE KNOW AND WHERE WE NEED TO GO (Cindy P. Lawler and Alycia Halladay). 11 ACTIONS OF MANGANESE ON PUBERTAL DEVELOPMENT (W. Les Dees, Jill K. Hiney, and Vinod K. Srivastava). 12 EXPOSURE OF THE DEVELOPING BRAIN TO POLYCHLORINATED BIPHENYLS INFLUENCES THE SUSCEPTIBILITY OF THE ADULT BRAIN TO STRESS (Pamela J. Lein, Kyung Ho Kim, Robert F. Berman, and Isaac N. Pessah). 13 A NEURODEVELOPMENTAL ORIGIN FOR PAKINSON'S DISEASE: A LINK TO THE FETAL BASIS FOR ADULT DISEASE HYPOTHESIS (D. Urbach-Ross and M. Thiruchelvam). 14 GENETIC AND ENVIRONMENTAL FACTORS IN ATTENTION-DEFICIT HYPERACTIVITY DISORDER (Angela Baker, Michele M. Taylor, and Jason R. Richardson). IV RISK ASSESSMENT OF METHYL MERCURY AND ITS EFFECTS ON NEURODEVELOPMENT (Michael Aschner). 15 FISH NUTRIENTS AND METHYLMERCURY: A VIEW FROM THE LABORATORY (M. Christopher Newland). 16 NEURODEVELOPMENTAL EFFECTS OF MATERNAL NUTRITION STATUS AND EXPOSURE TO METHYL MERCURY FROM EATING FISH DURING PREGNANCY: EVIDENCE FROM THE SEYCHELLES CHILD DEVELOPMENT STUDY (Philip W. Davidson, J.J. Strain, Gary J. Myers, Conrad F. Shamlaye, Sally Thurston, Maxine P. Bonham, Emeir M. Duffy, Julie M.W. Wallace, Gene Watson, and Thomas W. Clarkson). 17 METHYLMERCURY NEUROTOXICOLOGY: FROM RARE POISONINGS TO SILENT PANDEMIC (Philippe Grandjean, Anna L. Choi, Pal Weihe, and Katsuyuki Murata). 18 OXIDATIVE STRESS AND METHYLMERCURY-INDUCED NEUROTOXICITY (Marcelo Farina, Joa ~o Batista Teixeira Rocha, and Michael Aschner). 19 LEARNING DEFICITS AND DEPRESSION-LIKE BEHAVIORS ASSOCIATED WITH DEVELOPMENTAL METHYLMERCURY EXPOSURES (Natalia Onishchenko and Sandra Ceccatelli). 20 METHYLMERCURY EFFECTS ON NEURAL DEVELOPMENTAL SIGNALING PATHWAYS (Matthew D. Rand). V AUTISM SPECTRUM DISORDERS (Isaac N. Pessah). 21 NEURODEVELOPMENTAL TOXICOLOGY AND AUTISM SPECTRUM DISORDERS (Robert F. Berman, Claire M. Koenig, Michael R. Hunsaker, Isaac N. Pessah, and Janine M. Lasalle). 22 REDOX IMBALANCE AND THE METABOLIC PATHOLOGY OF AUTISM (Richard C. Deth, Mostafa Waly, Christina Muratore, and Nathaniel Hodgson). 23 NEUROINFLAMMATION AND AUTISM (G. Jean Harry). 24AUTISM, PERIPHERAL IMMUNITY, AND POLYBROMINATED DIPHENYL ETHERS (Paula Goines, Paul Ashwood, and Judy Van de Water). 25 AN EMERGING GENE–ENVIRONMENT INTERACTION MODEL: AUTISM SPECTRUM DISORDER PHENOTYPES RESULTING FROM EXPOSURE TO ENVIRONMENTAL CONTAMINANTS DURING GESTATION (Darryl B. Hood, Daniel Campbell, and Pat Levitt). STRATEGIES AND PROGRESS IN EPILEPSY RESEARCH (Merle G. Paule). VI STRATEGIES AND PROGRESS IN EPILEPSY RESEARCH (Merle G. Paule). NEONATAL SEIZURES (Renee A. Shellhaas). 27 EXPERIMENTAL MODELS OF EPILEPTOGENESIS (Hana Kubova). 28 EFFECT OF SEIZURES ON THE DEVELOPING BRAIN: LESSONS FROM THE LABORATORY (Shaun Hussain and Raman Sankar). INDEX.

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Book SynopsisBipolar Disorder Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant comorbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is both relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have Trade Review"...The textbook is also an ideal starting point for trainees and young investigators just beginning to explore these subjects. Biopolar Disorder: Clinical and Neurobiological Foundations, then, is a useful addition to the library of most clinicians and academic psychiatrists" (Journal of Clinical Psychiatry, 2011) "The book is a valuable guide to every psychiatrist. It contains a rich and wide range of information about bipolar disorder, step by step from criteria and definitions through biological changes to medical and psychotherapeutic treatment. The reader gets an overview over the newest findings which are presented in a very accessible way. It is definitely a book necessary for each modern psychiatrist!" (Acta Psychiatrica Scandinavica, 2011) "Contributors to 38 chapters offer international perspectives on the disorder's clinical and neurobiological foundations as defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases." (SciTech Book News, December 2010) Table of ContentsPreface. List of Contributors. 1 From Mania to Bipolar Disorder (David Healy). 2 Clinical Features and Subtypes of Bipolar Disorder (Fred K. Goodwin and D.Z. Lieberman). 3 The Long-Term Course and Clinical Management of Bipolar I and Bipolar II Disorders (Lewis L. Judd and Pamela J. Schettler). 4 Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders (Mark A. Frye and Giulio Perugi). 5 DSM-V Perspectives on Classification of Bipolar Disorder (Jan Fawcett). 6 Update on the Epidemiology of Bipolar Disorder (Kathleen R. Merikangas and Tracy L. Peters). 7 Suicide and Bipolar Disorder (Zoltan Rihmer and Jan Fawcett). 8 Neurocognition in Bipolar Disorder (Ivan J. Torres and Gin S. Malhi). 9 The Genius-Insanity Debate: Focus on Bipolarity, Temperament, Creativity and Leadership (Hagop S. Akiskal and Kareen K. Akiskal). 10 Economics of Bipolar Disorder (R. Sabes-Figuera, D. Razzouk and Paul E. McCrone). 11 An Introduction to the Neurobiology of Bipolar Illness Onset, Recurrence and Progression (Robert M. Post and Marcia Kauer-Sant.Anna). 12 Genetics of Bipolar Disorder (Falk W. Lohoff and Wade H. Berrettini). 13 Structural Brain Imaging in Bipolar Disorder (Paolo Brambilla and Jair C. Soares). 14 Functional Magnetic Resonance Imaging, Diffusion Tensor Imaging, and Magnetic Resonance Spectroscopy in Bipolar Disorder (In Kyoon Lyoo and Perry F. Renshaw). 15 Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow (John O. Brooks III, Po W. Wang and Terence A. Ketter). 16 Neurotransmitter Systems in Bipolar Disorder (Marina Nakic, John H. Krystal and Zubin Bhagwagar). 17 Molecular Biology of Bipolar Disorder (Ana Andreazza, Jun Feng Wang and Trevor Young). 18 Mitochondrial Dysfunction and Oxidative Stress (Tadafumi Kato, Flavio Kapczinski and Michael Berk). 19 Neuroendocrinology of Bipolar Illness (Timothy Dinan and Michael Bauer). 20 Circadian Rhythms and Sleep in Bipolar Disorder (Greg Murray and Allison Harvey). 21 Treatment Adherence in Bipolar Disorder (Jan Scott and Mary Jane Tacchi). 22 Acute Mania (Paul E. Keck, Jr, Susan L. McElroy and John M. Hawkins). 23 Pharmacological Treatment of Bipolar Depression (Allan H. Young and Charles B. Nemeroff). 24 Practical Pharmacological Maintenance Treatment of Bipolar Disorder (Alan C. Swann). 25 Rapid Cycling Bipolar Disorder: Phenomenology and Treatment (Joseph F. Goldberg and Michael Berk). 26 Management of Bipolar II Disorder (Gordon Parker and Terence A. Ketter). 27 Management of Comorbidity in Bipolar Disorder (Ihsan M. Salloum, Luca Pani and Tiffany Cooke). 28 Bipolar Disorder and Safety Monitoring for Clinicians: A Review of the Evidence and the Implications (Chris J. Bushe and Mauricio Tohen). 29 Somatic Treatments for Bipolar Disorder: ECT, VNS and TMS (Mark S. George). 30 Novel Therapeutic Strategies for Bipolar Disorder (Rodrigo Machado-Vieira, Husseini K. Manji and Carlos A. Zarate Jr). 31 Psychoeducation as a Core Element of Psychological Approaches for Bipolar Disorders (Francesc Colom and Lesley Berk). 32 Cognitive-Behavioural Therapy for Bipolar Disorder (Sagar V. Parikh and Jan Scott). 33 Interpersonal and Social Rhythm Therapy for Bipolar Disorder (Holly A. Swartz, Ellen Frank, Laura E. Zajac and David J. Kupfer). 34 Family Therapy Approaches to Bipolar Disorder (David J. Miklowitz). 35 Collaborative Care for Bipolar Disorder (Amy M. Kilbourne, David E. Goodrich and Mark S. Bauer). 36 Bipolar Disorder in Women (Benicio N. Frey, Karine A. Macritchie, Claudio N. Soares and Meir Steiner). 37 Phenomenology and Treatment of Bipolar I Disorder in Children: A Critical Review (Gabrielle A. Carlson and Elizabeth B. Weller). 38 Bipolar Disorder in the Elderly (Martha Sajatovic and Lars Vedel Kessing). Index.

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Book SynopsisA breakthrough work in neuroscience—and an incisive corrective to a long history of damaging pseudoscience—that finally debunks the myth that there is a hardwired distinction between male and female brains We live in a gendered world, where we are ceaselessly bombarded by messages about sex and gender. On a daily basis, we face deeply ingrained beliefs that sex determines our skills and preferences, from toys and colors to career choice and salaries. But what does this constant gendering mean for our thoughts, decisions and behavior? And what does it mean for our brains?Drawing on her work as a professor of cognitive neuroimaging, Gina Rippon unpacks the stereotypes that surround us from our earliest moments and shows how these messages mold our ideas of ourselved and even shape our brains. By exploring new, cutting-edge neuroscience, Rippon urges us to move beyond a binary view of the brain and to see instead this complex organ as highly individ

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Book SynopsisA fascinating, darkly funny comeback story of learning to live with a broken mind after a near-fatal traumatic brain injury—from the acclaimed author of The Hike“Drew Magary has produced a remarkable account of his journey, one that is filled with terror, tenderness, beauty, and grace.”—David Grann, bestselling author of Killers of the Flower Moon Drew Magary, fan-favorite Defector and former Deadspin columnist, is known for his acerbic takes and his surprisingly nuanced chronicling of his own life. But in The Night the Lights Went Out, he finds himself far out of his depths. On the night of the 2018 Deadspin Awards, he suffered a mysterious fall that caused him to smash his head so hard on a cement floor that he cracked his skull in three places and suffered a catastrophic brain hemorrhage. For two weeks, he remained in a coma. The world was gone to him, and him to it. In his long recovery

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Book SynopsisAn essential primer based on a renowned new model of care that is comprehensive and research based, while honoring the uniqueness of every childAn estimated one in thirty-six children in the United States is diagnosed with autism. New research has shed light on the many factors that determine a child’s trajectory—but many parents are still navigating this complex terrain without a road map. Pediatric neurologist Dr. Suzanne Goh has spent decades working with autistic children, and in this practical and research-based guide she shares her renowned and revolutionary model of care: an innovative, whole-child approach that combines optimal medical treatment with the most effective strategies for advancing cognition, communication, and behavior.Demystifying a wide range of diagnostics and therapies and offering new insights into the neurological, biochemical, behavioral, and social factors that play a role in successful outcomes, the book is an essential resource for understanding all of autism—a strengths-based approach that helps parents design a comprehensive treatment plan. It is also a celebration of what each autistic person brings to the world—and how parents can best nurture the remarkable uniqueness of their child while setting them up for the future they envision.

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Book SynopsisCracking the Genome is the definitive, balanced account of how the code that holds the answer to the origin of life, the evolution of humanity, and the future of medicine was finally broken.Trade Review"For an up-to-the-minute account of one of the most dramatic periods in present-day science, Cracking the Genome is an essential read. Sunday Times A superb job... A tantalizing glimpse of the ethical perils and technological possibilities awaiting humanity. Los Angeles Times A rollicking good tale about an enduring intellectual monument. American Scientist The race is over, and Davies was there, all along, providing the running commentary-and there, too, at the finish line. In Cracking the Genome, he hands out the prizes. The Independent Davies has tracked one of the most important stories ever to unfold. Davies helps readers understand how the deciphering of our genetic code will revolutionize our lives while posing serious ethical dilemmas. Science News An impressive job of contextualizing the science within a political, economic, and social framework, creating a lively tale as accessible to non-specialists as it is to scientists. Publishers Weekly Investors and others looking for a quick primer on the science and business of biotechnology will find this a useful guide. Business Week In Davies' prose, this story of molecular biology and the Human Genome Project is as compelling as any Arthurian legend. In a fast-moving approachable style, Davies captures the uncovering of biology's Holy Grail, relying on his own expertise in genetics and interviews with key players such as Collins and Venter. -- Margaret R. McLean History and Philosophy of the Life Sciences 2004Table of ContentsPreface to The Johns Hopkins EditionIntroduction Chapter 1. Knights of the Double Helix: The Quest for Biology's Holy GrailChapter 2. Reading the Book of Life: A Quick Voyage around the Human GenomeChapter 3. The Eye of the TIGR: J. Craig Venter—Maverick SequencerChapter 4. Loading the Bases: Francis Collins and the DNA DetectivesChapter 5. The Circle of Life: Decoding the First Free-Living CreaturesChapter 6. Treasures of the Lost Worlds: The Keys to Human Disease from Tristan da Cunha to IcelandChapter 7. Prize Fight: The Creation of Celera GenomicsChapter 8. The Story of Us: The Secrets of Who We AreChapter 9. The Croesus Code: Passion, Personality, and ProfitChapter 10. The Eighth Day: Braving the New World of Designer GenesChapter 11. The Language of God: A Defining Moment in the History of the Human RaceChapter 12. Genomania!NotesAcknowledgments Index

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Book SynopsisThe paperback edition brings the discussion of treatment options and research thoroughly up to date.Trade ReviewThe beauty of Havemann's narrative stance is that it not only transcends the illness but surprises and captivates the reader... -- Abraham Verghese Los Angeles Times Book Review [Havemann] takes us on his journey from a physically robust, high achiever to his new world of medication dependence, compromise, and, eventually, an almost spiritual epiphany of acceptance and appreciation. This is not a typical treatise on an individual's life with disease. It is filled with useful facts about PD, including diagrams, and a glossary that will be a useful resource for patients... Although this book would seem of primary interest to patients and families affected by PD, physicians will find the book engaging, easy to read, and valuable. We learn much from our patients, and Havemann's book is no exception. -- Matthew B. Stern Neurology Brutally honest. Havemann intertwines his personal story with scientific and medical information. He brings a journalistic style to the tale and explains PD and its treatments in easy-to-understand language. His description of the progressive nature of the disease is poetic and haunting. -- Robert A. Hauser Journal of the American Medical Association Havemann has written a challenging mixture of dispassionate appraisal of the facts and vivid portrayal of his personal experiences adapting to living with the disorder. -- Stephen B. Dunnett Nature MedicineTable of ContentsForewordAcknowledgmentsIntroduction: As I Lay TremblingChapter 1. Denial and IgnoranceChapter 2. Myself Before Parkinson'sChapter 3. The Magnificent BrainChapter 4. Escaping AbroadChapter 5. The Darkest HourChapter 6. Today's DrugsChapter 7. Today's SurgeriesChapter 8. An Insidious BeastChapter 9. Keeping the Beast at BayChapter 10. Tomorrow's RemediesEpilogue: Light in the DarknessGlossaryNotesIndex

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Book SynopsisD., University of Southern CaliforniaTrade ReviewEffectively and skillfully integrates current basic and clinical research data related to the use of HT and provides guidelines for treatment and future research. -- April L. Carbone PsycCRITIQUES 2007 The Effects of Estrogen on Brain Function... is a nice collection of reviews from established experts in the estrogen field. These chapters provide a range of information from different levels of analysis that help to synthesize what is known about estrogen and the brain. -- Julie A. Dumas Sex Roles 2008Table of ContentsList of ContributorsIntroductionChapter 1. Preclinical Data Relating to Estrogen's Effects on Cognitive PerformanceChapter 2. The Short-Lived Effects of Hormone Therapy on Cognitive FunctionChapter 3. Clinical Data from Structural and Functional Brain Imaging on Estrogen's Effects in the Central Nervous SystemChapter 4. Clinical Data on Estrogen's Effects on MoodChapter 5. Preclinical Efforts to Develop Effective NeuroSERMs for the BrainChapter 6. Basic and Clinical Data on the Effects of SERMs on CognitionConclusionIndex

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Book SynopsisFor two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions-including fatal familial insomnia, kuru, scrapie, and mad cow disease-share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA-and the diseases they bring are now spreading around the wo

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Book SynopsisTHE INSPIRATION FOR THE NBC SERIES BRILLIANT MINDS • A Contemporary Classics hardcover edition of Dr. Sacks's most extraordinary book, in which the poet laureate of medicine” (The New York Times) recounts fascinating case histories of patients with neurological disorders.An influential landmark in the tradition of writing about the body and the brain, The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with perceptual and intellectual disorders: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; whose limbs seem alien to them; who lack some skills yet are gifted with uncanny artistic or mathematical talents.In Dr. Sacks’s splendid and sympathetic telling, his patients are deeply human and his tales are studies of struggles against incredible adversity. A great healer, Sacks never loses sight of medicine’s ultimate responsibility: “the suffering, afflicted, fighting human subject.”Everyman's Library pursues the highest production standards, printing on acid-free paper, with full-cloth cases with two-color foil stamping, decorative endpapers, silk ribbon markers, European-style half-round spines, and a full-color illustrated jacket. Contemporary Classics include an introduction, a select bibliography, and a chronology of the author's life and times.

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Book SynopsisIntroduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects.Table of ContentsList of contributors ix Foreword xiii Acknowledgements xv Notes on authors xvii Introduction 1 Section I: Neurobiology of pain: Recent advances 11 1 Anatomy of pain pathways 13 Andrew J. Todd 2 Spinal plasticity of the nociceptive system: The role of central sensitization in chronic pain states 35 Alban Latremolière 3 Symptoms and pathology in neuropathic pain 89 Matthew Thakur and Stephen B. McMahon 4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123 Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio 5 Genetics and epigenetics of pain 149 Franziska Denk and Stephen B. McMahon 6 The cannabinoid system and its role in nociception 169 Massimiliano Beltramo 7 EphB receptors and persistent pain 201 Isabella Gavazzi Section II: Pain in the brain 225 8 Brain imaging in experimental pain 227 Massieh Moayedi and Tim V. Salomons 9 Placebo effects in pain 249 Luana Colloca, Adam P. Horin and Damien Finniss 10 Psychology and pain 267 Lance M. McCracken Section III: Pain in the lifecycle and in nervous system disorders 281 11 Pain in neonates and infants 283 Fiona Moultrie, Sezgi Goksan, Ravi Poorun and Rebeccah Slater 12 How do people with autism spectrum disorders (ASD) experience pain? 295 Cecile Rattaz, Amandine Dubois and Amaria Baghdadli 13 Pain and depression: The janus factor of human suffering 317 Angela Iannitelli and Paola Tirassa 14 Pain in multiple sclerosis: From classification to treatment 345 Claudio Solaro and Michele Messmer 15 Pain perception in dementia 361 Miriam Kunz and Stefan Lautenbacher 16 The role of cognitive impairment in the placebo and nocebo effects 373 Martina Amanzio 17 An overview of pain in parkinson’s disease 387 Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri Appendix: Interviews with chronic pain patients 409 Index 000

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Book SynopsisA comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including AlzheimerTable of ContentsNotes on Contributors ix Introduction xxi Part I Models of Brain Disorders 1 1 A Computational Model of Dyslexics’ Perceptual Difficulties as Impaired Inference of Sound Statistics 3Sagi Jaffe-Dax, Ofri Raviv, Yonatan Loewenstein, and Merav Ahissar 2 Computational Approximations to Intellectual Disability in Down Syndrome 15Ángel E. Tovar, Ahmed A. Moustafa, and Natalia Arias-Trejo 3 Computational Psychiatry 29Robb B. Rutledge and Rick A. Adams 4 Computational Models of Post-traumatic Stress Disorder (PTSD) 43Milen L. Radell, Catherine E. Myers, Jony Sheynin, and Ahmed A. Moustafa 5 Reward Processing in Depression 57 The Computational ApproachChong Chen and Taiki Takahashi 6 Neurocomputational Models of Schizophrenia 73Ahmed A. Moustafa, B³a¿ej Misiak, and Dorota Frydecka 7 Oscillatory Dynamics of Brain Microcircuits 85 Modeling Perspectives and Neurological Disease ConsiderationsFrances K. Skinner and Alexandra Pierri Chatzikalymniou 8 Computational Models of Pharmacological and Immunological Treatment in Alzheimer’s Disease 99Vassilis Cutsuridis and Ahmed A. Moustafa 9 Modeling Deep Brain Stimulation for Parkinson’s Disease 109 Volume Conductor, Network, and Mean-Field ModelsMadeleine M. Lowery 10 The Development of Medications for Parkinson’s Disease Using Computational Modeling 125Mubashir Hassan and Ahmed A. Moustafa 11 Multiscale Computer Modeling of Epilepsy 139M. Sanjay, Samuel A. Neymotin, Srinivasa B. Krothapalli, and William W. Lytton Part II Neural Models of Behavioral Processes 151 12 Simple Models of Sensory Information Processing 153Danke Zhang, Malte J. Rasch, and Si Wu 13 Motion Detection 171An Artificial Recurrent Neural Network ApproachJeroen Joukes and Bart Krekelberg 14 Computation in the Olfactory System 185Christiane Linster 15 Computational Models of Olfaction in Fruit Flies 199Ankur Gupta, Faramarz Faghihi, and Ahmed A. Moustafa 16 Multisensory Integration 215 How the Brain Combines Information Across the SensesRyan L. Miller and Benjamin A. Rowland 17 Computational Models in Social Neuroscience 229Jin Hyun Cheong, Eshin Jolly, Sunhae Sul, and Luke J. Chang 18 Sleep is For the Brain 245 Contemporary Computational Approaches in the Study of Sleep and Memory and a Novel “Temporal Scaffolding” HypothesisItamar Lerner 19 Models of Neural Homeostasis 257Hazem Toutounji Part III Models of Brain Regions and Neurotransmitters 271 20 Striatum 273 Structure, Dynamics, and FunctionJyotika Bahuguna and Arvind Kumar 21 Amygdala Models 285Vinay Guntu, Feng Feng, Adel Alturki, Ajay Nair, Pranit Samarth, and Satish S. Nair 22 Cerebellum and its Disorders 303 A Review of Perspectives from Computational NeuroscienceShyam Diwakar and Ahmed A. Moustafa 23 Models of Dynamical Synapses and Cortical Development 321Radwa Khalil, Marie Z. Moftah, Marc Landry, and Ahmed A. Moustafa 24 Computational Models of Memory Formation in Healthy and Diseased Microcircuits of the Hippocampus 333Vassilis Cutsuridis 25 Episodic Memory and the Hippocampus 345Naoyuki Sato 26 How Do We Navigate Our Way to Places? 357 Developing a New Model to Study Place Field Formation in Hippocampus Including the Role of AstrocytesFariba Bahrami and Shiva Farashahi 27 Models of Neuromodulation 373Michael C. Avery and Jeffrey L. Krichmar 28 Neural Circuit Models of the Serotonergic System 389 From Microcircuits to CognitionPragathi Priyadharsini Balasubramani, V. Srinivasa Chakravarthy, KongFatt Wong-Lin, Da-Hui Wang, Jeremiah Y. Cohen, Kae Nakamura, and Ahmed A. Moustafa Part IV Neural Modeling Approaches 401 29 A Behavioral Framework for Information Representation in the Brain 403Frédéric Alexandre 30 Probing Human Brain Function with Artificial Neural Networks 413Umut Güçlü and Marcel van Gerven 31 Large-scale Computational Models of Ongoing Brain Activity 425Tristan T. Nakagawa, Mohit H. Adhikari, and Gustavo Deco 32 Optimizing Electrical Stimulation for Closed-loop Control of Neural Ensembles 439 A Review of Algorithms and ApplicationsSeif Eldawlatly 33 Complex Probabilistic Inference 453 From Cognition to Neural ComputationSamuel J. Gershman and Jeffrey M. Beck 34 A Flexible and Efficient Hierarchical Bayesian Approach to the Exploration of Individual Differences in Cognitive-model-based Neuroscience 467Alexander Ly, Udo Boehm, Andrew Heathcote, Brandon M. Turner, Birte Forstmann, Maarten Marsman, and Dora Matzke 35 Information Theory, Memory, Prediction, and Timing in Associative Learning 481Jason T. Wilkes and C. R. Gallistel 36 The Utility of Phase Models in Studying Neural Synchronization 493Youngmin Park, Stewart A. Heitmann, and G. Bard Ermentrout 37 Phase Oscillator Network Models of Brain Dynamics 505Carlo R. Laing 38 The Neuronal Signal and Its Models 519Igor Palmieri, Luiz H. A. Monteiro, and Maria D. Miranda 39 History Dependent Neuronal Activity Modeled with Fractional Order Dynamics 531Seth H. Weinberg and Fidel Santamaria Index 549

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Book SynopsisNeuroendocrinology with its well defined functions, inputs, and outputs, is one of the most fertile grounds for computational modeling in neuroscience. But modeling is often seen as something of a dark art.Table of ContentsList of Contributors, vii Series Preface, ix Preface, xi About the Companion Website, xv 1 Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability, 1David P. McCobb and Mary Lou Zeeman 2 Ion Channels and Electrical Activity in Pituitary Cells: A Modeling Perspective, 80Richard Bertram, Joël Tabak, and Stanko S. Stojilkovic 3 Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations, 111Arthur Sherman 4 A Mathematical Model of Gonadotropin-Releasing Hormone Neurons, 142James Sneyd, Wen Duan, and Allan Herbison 5 Modeling Spiking and Secretion in the Magnocellular Vasopressin Neuron, 166Duncan J. MacGregor and Gareth Leng 6 Modeling Endocrine Cell Network Topology, 206David J. Hodson, Francois Molino, and Patrice Mollard 7 Modeling the Milk-Ejection Reflex, 227Gareth Leng and Jianfeng Feng 8 Dynamics of the HPA Axis: A Systems Modeling Approach, 252John R. Terry, Jamie J. Walker, Francesca Spiga, and Stafford L. Lightman 9 Modeling the Dynamics of Gonadotropin-Releasing Hormone (GnRH) Secretion in the Course of an Ovarian Cycle, 284Frédérique Clément and Alexandre Vidal Glossary, 305 Index, 315

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Book Synopsis

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Book SynopsisHow do our brains store—and then conjure up—past experiences to make us who we are?Trade Review"[A] roving, riverine inquiry into memory, experience, the brain…O'Keane does not try to dazzle us with interpretations and cures, but dazzle she does with the science, the clarity with which she can conjure something as ordinary, as bafflingly complex and beautiful, as a memory forming in the brain." -- Parul Sehgal, The New York Times"These passages are vivid and immediate, and all the more affecting for the measured and unemphatic manner in which they are set down. If O’Keane is as fine a doctor as she is a prose stylist, her patients are fortunate indeed." -- John Banville, Guardian"[O'Keane's] unforgettable trip down memory’s many lanes leaves you with a marvelling awareness of what humans collectively share as memory makers and, at the same time, reminds us that each one of us is a singular translator of our world." -- London Observer"Rich, revelatory and, in the best way, unsettling." -- London Sunday Times"A comprehensive tour of the current state of knowledge about how memory operates in the brain." -- Elizabeth Landau, Undark"[O'Keane] delivers interesting observations on nearly every page…A welcome new voice in the literature of consciousness and neuroscience." -- Kirkus Reviews"O'Keane offers no shortage of intriguing insights and accounts…[A]n immersive and informative look at how memory works, and what happens when it doesn't." -- Publishers Weekly"Wonderful. I love the way Veronica O’Keane writes…difficult concepts made comprehensible with rich case studies. A must read for every counselor, psychotherapist, life coach and psychiatrist." -- Philippa Perry, author of The Book You Wish Your Parents Had Read"Veronica O’Keane distills what she has learned about people in her life as a psychiatrist and neuroscientist. The reader will appreciate Dr. O’Keane’s beautiful prose and her caring attitudes, and will effortlessly pick up knowledge about how the brain determines our behavior." -- Robin Murray, professor of psychiatric research, King’s College, London

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Book SynopsisEdited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: PrinciplTrade Review"This high quality book will be an excellent reference for both fellows and attending physicians who care for patients with leukemic disorders in either a community or academic setting . . . This book is a welcome resource for those entering the field as well as for long-time practitioners who want to stay up to date." (Doody's, 12 August 2011)Table of ContentsContributors. Preface. Part 1: Background and Diagnostic. 1. Stem Cell Biology in Normal and Malignant Hematopoiesis (Amer Zeidan and Meir Wetzler). 2. Epidemiology and Etiology of Leukemias (Andrew Fletcher, Annika Whittle and David Bowen). 3. Traditional Diagnostic Approaches (Hartmut Koeppen, Carlos E. Bueso-Ramos and Sergej N. Konoplev). 4. Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification (Maher Albitar). 5. Non-cytogenetic Markers and Their Impact on Prognosis (Eric Schafer and Donald Small). Part 2: Myelodysplastic syndromes (MDS). 6. Myelodysplastic Syndromes: Pathophysiology (Steven D. Gore and Erica Warlick). 7. Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment (Ulrich Germing). 8. Myelodysplastic Syndromes (William Stevenson and Guillermo Garcia-Manero). Part 3: Acute Myeloid Leukemia (AML). 9. Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia (Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, and Ulrike Bacher). 10. Induction Therapy of Acute Myeloid Leukemia (Martha Wadleigh and Daniel J. DeAngelo). 11. Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies (Keith W. Pratz and Judith E. Karp). 12. Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia (Gheath Alatrash and Marcos de Lima). Part 4: Acute Promyelocytic Leukemia (APL). 13. The Pathophysiology of Acute Promyelocytic Leukemia (Francesco Lo-Coco and Syed Khizer Hasan). 14. Acute Promyelocytic Leukemia (APL): Manifestations and Therapy (Sylvain Thépot, Lionel Ades, Pierre Fenaux). Part 5: Acute Lymphoblastic Leukemia (ALL). 15. Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification (Sandeep Gurbuxani and John Anastasi). 16. Induction Therapy in Adult Acute Lymphoblastic Leukemia (Xavier Thomas). 17. Salvage Therapy of Adult Acute Lymphoblastic Leukemia (Nicola Gökbuget and Dieter Hoelzer). 18. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Current Treatment Status and Perspectives (Olga Sala-Torra and Jerald P. Radich). 19. Acute Lymphoblastic Leukemia in Adolescents and Young Adults (Michael E. Rytting). 20. The Role of Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (Partow Kebriaei). Part 6: Chronic Myeloid Leukemia (CML). 21. Pathophysiology of Chronic Myeloid Leukemia (Agnes S. M. Yong and Junia V. Melo). 22. Therapy of Newly Diagnosed and Chronic Phase Chronic Myelogenous Leukemia (Andreas Hochhaus). 23. Therapy of Advanced Stage and Resistant Chronic Myeloid Leukemia (Devendra K. Hiwase and Timothy P. Hughes). Part 7: Chronic Lymphocytic Leukemia. 24. Chronic Lymphocytic Leukemia: Pathophysiology, Diagnosis and Manifestations, and Prognostic Markers (Thorsten Zenz, Hartmut Döhner, Stephan Stilgenbauer). 25. Therapy of Chronic Lymphocytic Leukemia – Frontline and Salvage (Valentin Goede, Barbara Eichhorst, and Michael Hallek). 26. The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia (Simon Hallam and John G. Gribben). 27. Special Situations: Management of Elderly Patients and CLL Transformation (Wei-Gang Tong and Alessandra Ferrajoli). Part 8: Other Leukemic Disorders. 28. Hairy Cell Leukemia (Farhad Ravandi). 29. Therapeutic Approaches to the Mature T-cell Lymphoproliferative Leukaemias (Nnenna Osuji and Claire Dearden). 30. Philadelphia Chromosome Negative Myeloproliferative Neoplasms (Ruben A. Mesa and Srdan Verstovsek). Part 9: General Treatment Principles and Clinical Developments. 31. Management of Emergencies in Leukemias (Olga Frankfurt). 32. Management of Infectious Complications in Patients with Leukemia (Marcio Nucci, Nair Bijay and Elias Anaissie). 33. Transfusion Support and Hematopoietic Growth Factors (Paolo Rebulla). 34. New Designs for Clinical Trials: AML as an Example (Elihu Estey). Index. The color plate section.

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Book SynopsisEvidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with Recommendations' based on strong evidence and Good Practice Points' where only weaker evidence is available. The Guidelines in this volume cover: Investigation Major neurological diseases Neuromuscular diseases Infections Neurological problems Sleep disordersTrade Review“Well written, easy to read, and highly educational, this book is a very nice addition to a neurologist's professional library.” (Doody’s, 2 November 2012) Table of ContentsIntroduction. Section 1 Investigations. 1 Routine cerebrospinal fluid (CSF) analysis. 2 Use of imaging in cerebrovascular disease. 3 Use of imaging in multiple sclerosis. 4 Neurophysiological tests and neuroimaging procedures in non-acute headache. 5 Use of anti-interferon beta antibody measurements in multiple sclerosis. 6 Use of antibody testing in nervous system disorders. 7 Use of skin biopsy in the diagnosis of small fibre neuropathy. 8 Assessment of neuropathic pain. Section 2 Major Neurological Diseases. 9 Ischaemic stroke and transient ischaemic attack. 10 Drug treatment of migraine. 11 Cluster headache and other trigemino-autonomic cephalgias. 12 Diagnosis and treatment of primary (idiopathic) dystonia. 13 Mild traumatic brain injury. 14 Early (uncomplicated) Parkinson's disease. 15 Late (complicated) Parkinson's disease. 16 Alzheimer's disease. Section 3 Neuromuscular Diseases. 17 Management of amyotrophic lateral sclerosis. 18 Post-polio syndrome. 19 Autoimmune neuromuscular transmission disorders. 20 Chronic infl ammatory demyelinating polyradiculoneuropathy. 21 Multifocal motor neuropathy. 22 Paraproteinaemic demyelinating neuropathies. 23 Limb girdle muscular dystrophies. Section 4 Infections. 24 Neurological complications of HIV infection. 25 Viral meningo-encephalitis. Section 5 Neurological Problems. 26 Treatment of neuropathic pain. 27 Acute relapses of multiple sclerosis. 28 Status epilepticus. 29 Alcohol-related seizures. 30 Brain metastases. 31 Paraneoplastic neurological syndromes. 32 Nystagmus and oscillopsia. 33 Orthostatic hypotension. 34 Cerebral venous and sinus thrombosis. 35 Cerebral vasculitis. 36 Neurological problems in liver transplantation. 37 Fatty acid mitochondrial disorders. Section 6 Sleep Disorders. 38 Management of narcolepsy in adults. 39 Sleep disorders in neurodegenerative disorders and stroke. Section 7 Rehabilitation. 40 Cognitive rehabilitation. Index.

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Book SynopsisAnd although McLay remains unsure why or how, his experiences hold out hope for those suffering from this devastating disorder.Trade ReviewHighly recommended for military and psychology holdings alike. Midwest Book Review Thoroughly recommended as a humane, insightful, and very readable book. -- Chris R. Brewin European Journal of Psychotraumatology Recommended to the general reader interested in the effects of war and the importance of finding new and better ways to treat those effects. Choice Accessible, informative and compelling. -- Taylor Poor National Alliance on Mental Illness Though useful for mental health professionals from different backgrounds (i.e. psychologists, social workers, psychiatrists, patient care technicians, etc.), this work is also intended for those who have experienced symptoms of PTSD or know someone who has... There are many books that discuss virtually every aspect of PTSD... few offer such a personal, frontline glimpse into the challenges mental health professionals face in providing accurate assessment and treatment services for military personnel. -- Steven T. Herron, MD Doody's Review ServiceTable of ContentsPrologue1. Why This Book Was Written2. What Is PTSD Anyway? Looking at the Problem before Iraq3. Every War Is Different, Every War Is the Same4. Mind and Brain5. The Forgotten War6. Treatment and Cure7. I Don't Believe in That Stuff: Arguments against the Existence of PTSD8. Some Birthday: Attempts to Prevent PTSD9. Iraq in Digital10. Women at War11. Memorial Day in Camp Fallujah12. It Just Might Work13. The State of the Science14. Therapy in Foxholes15. The War at Home16. Virtual Reality Faces the Real Thing17. Different Roads Home18. A Kind of Peace: What We Learned and What We Have Left to AccomplishAcknowledgmentsIndex

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Book SynopsisThe Intentional Brain is a marvelous and interdisciplinary look at the clinical interface between the mind and the brain.Trade ReviewIt reminded me exactly why I love psychiatry, for its complex history and ongoing scientific mystery. If you are feeling in need of a reminder of how far we have come, Trimble may provide just that inspiration. British Society for the History of MedicineTable of ContentsPreface1. Origins of the Romance2. The Middle Ages3. The Renaissance4. The Enlightenment5. Romanticism6. Late Romanticism7. Charcot's Joints8. The Division of the Hemispheres9. Fin de Siècle10. The Turn of the Screw11. The In-Between Years12. After the War13. Coda14. Neuropsychiatry, Then and NowAcknowledgmentsName IndexSubject Index

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Book SynopsisWiesman provides hope, help, and comfort to patients, families, and caregivers.Trade ReviewAn excellent book that I would recommend to my patients. Dr. Wiesman does a good job explaining difficult medical concepts in laymen's terms. Ahmet Hoke, MD, PhD, Professor of Neurology, Johns Hopkins University School of Medicine Very well written in simple language, this book covers many aspects of neuropathy that would be of use to any sufferer... This book would be a useful read to any person who has the need of personal insight to this condition, either as a sufferer or family member. Nursing TimesTable of ContentsPreface Chapter 1. What Is a Nerve? Chapter 2. What Is Neuropathy? Chapter 3. Symptoms of Neuropathy Chapter 4. Causes of Neuropathy Chapter 5. How Is Neuropathy Diagnosed? Chapter 6. Tests Chapter 7. Treatment of Neuropathy Chapter 8. Clinical Trials Chapter 9. Things that Feel Like Neuropathy but Are Something Else Chapter 10. Living with Neuropathy Glossary Acknowledgments References Resources Index

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Book SynopsisThis book explains how the brain interacts with the social worldand why stories matter. How do our brains enable us to tell and follow stories? And how do stories affect our minds? In Stories and the Brain, Paul B. Armstrong analyzes the cognitive processes involved in constructing and exchanging stories, exploring their role in the neurobiology of mental functioning. Armstrong argues that the ways in which stories order events in time, imitate actions, and relate our experiences to others' lives are correlated to cortical processes of temporal binding, the circuit between action and perception, and the mirroring operations underlying embodied intersubjectivity. He reveals how recent neuroscientific findings about how the brain workshow it assembles neuronal syntheses without a central controllerilluminate cognitive processes involving time, action, and self-other relations that are central to narrative. An extension of his previous book, How Literature Plays with the Brain, this nTrade ReviewStories and the Brain is a well-researched, engaging discussion on what narrative theory and neuroscience stand to gain from continued collaboration.—CerebrumTable of ContentsAcknowledgmentsPrologueChapter 1. Neuroscience and Narrative TheoryChapter 2. The Temporality of Narrative and the Decentered BrainChapter 3. Action, Embodied Cognition, and the As-If of Narrative FigurationChapter 4. Neuroscience and the Social Powers of NarrativeEpilogueNotesWorks CitedIndex

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Book SynopsisOverseen by distinguished neuropsychiatrist Dr. Richard Restak, Brainis both a practical owner’s manual and a complete guide to the brain’s development and function.

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisLong-term survival from traumatic brain injury is greatly increased if management guidelines are properly followed. This book provides practical guidance to neurologists throughout the patient journey from severe head injury, treatment in the Intensive Care Unit, through to discharge, rehabilitation, and recovery.Table of ContentsList of contributors vii Preface x Acknowledgments xii Part I: Introduction and imaging 1 The clinical problem of traumatic head injury 3 Ramon Diaz-Arrastia and Pieter E. Vos 2 Neuroimaging in traumatic brain injury 13 Pieter E. Vos Carlos Marquez de la Plata and Ramon Diaz-Arrastia Part II: Prehospital and ED care 3 Out-of-hospital management in traumatic brain injury 45 Peter R.G. Brink 4 Emergency department evaluation of mild traumatic brain injury 55 Noel S. Zuckerbraun C. Christopher King and Rachel P. Berger 5 In-hospital observation for mild traumatic brain injury 71 Pieter E. Vos and Dafin F. Muresanu Part III: In hospital 6 ICU care: surgical and medical management—indications for immediate surgery 89 Peter S. Amenta and Jack Jallo 7 ICU care: surgical and medical management—neurological monitoring and treatment 115 Luzius A. Steiner 8 ICU care: surgical and medical management—systemic treatment 134 Lori Shutter Part IV: Rehabilitation 9 Rehabilitation of cognitive deficits after traumatic brain injury 165 Philippe Azouvi and Claire Vallat-Azouvi Part V: Postacute care and community in reintegration 10 Epidemiology of traumatic brain injury 183 Ramon Diaz-Arrastia and Kimbra Kenney 11 Neuropsychiatric and behavioral sequelae 192 Kathleen F. Pagulayan and Jesse R. Fann 12 Follow-up and community integration of mild traumatic brain injury 211 Joukje van der Naalt and Joke M. Spikman Index 226

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Book Synopsis

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