Neurology and clinical neurophysiology Books

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Book SynopsisAutism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.

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Book SynopsisProgressive myoclonus epilepsies are a group of rare genetic diseases. The onset generally occurs around puberty in otherwise healthy children. They all involve myoclonus and epilepsy but then differ depending on the different symptoms that are related. The outlook of these diseases is nearly always unfavourable and treatment only focuses on symptoms. Much planning will be needed to improve the quality of life for these children who will gradually become over time more and more severely disabled. Among these diseases, the most notable is Unverricht-Lundborg disease and Lafora disease, among others. However, the genetic mechanism of these diseases is simple and has been perfectly identified over time thanks to advancements in scientific discoveries. Hope lies in gene therapy, which in the near future will most likely be able to optimise treatment and even cure these children. This book addresses the situation by relying on clinicians descriptions, studies led by biologists on genetic variations and mutations and the work carried out daily by numerous scientists researching into treatment. By retracing the history of these diseases, from discovery and identification of mutated genes to the review of syndromes they encompass, this book marks the path we have travelled but also the distance we have yet to go.

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Book SynopsisThis report of the ILAE Child Neuropsychiatry Taskforce, Neuropsychobiology Commission, was published as an e-supplement in Epileptic Disorders (Volume 8, May 2016), educational journal of the International League Against Epilepsy. Psychiatric and behavioural problems are reported to occur in 35-50% of children with epilepsy. They affect the quality of the childrens and their families lives in a very challenging manner. The ad hoc Commissions and Taskforces of the International League Against Epilepsy are regularly following progress made in the field, also promoting a larger diffusion of existing knowledge and future research. The present report is a state-of-the-art critical review, putting together numerous data concerning topics such as epidemiology, pharmacotherapy, the effects of antiepileptic drugs and epilepsy surgery, the relationships between epilepsy and many psychiatric disorders. It also points out the specific areas in need of controlled trials, such as early diagnosis and management. This report was published as an e-supplement in Epileptic Disorders (Volume 8, May 2016), educational journal of the International League Against Epilepsy.

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Book SynopsisThis is not just a treatise upon insanity and its varied therapeutic measures, rather it is the outcome of various years of clinical experience of a dedicated medical practitioner, who has tried to explain the nature of the disease under consideration, its causes, its tendencies and its conclusions under favourable treatment. It shall became an aid to the medical students in the acquisition of knowledge, and to the busy practitioner in the care and cure of the sick.

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Book SynopsisA leading researcher in brain dysfunction and a Wall Street Journal science writer demonstrate that the human mind is an independent entity that can shape and control the physical brain.

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Book SynopsisDrs. Carrion and Weems present the first book to be published on the neuroscience of pediatric PTSD. Children who experience traumatic stress early in life are at risk of developing scholastic, social, emotional and cognitive difficulties. In this book the authors present a compelling story on how neuroscience findings explain the difficulties these children are challenged with.Table of ContentsPrologue Introduction Chapter 1: Executive Function Chapter 2: Memory Chapter 3: Emotion Processing Chapter 4: Dissociation Chapter 5: Sleep Chapter 6: Self-Injurious Behaviors Chapter 7: Comorbidity in Pediatric PTSD Chapter 8: Treatment Outcomes Chapter 9: Brain Function in Pediatric PTSD: Review and Implications

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Book SynopsisBrain Imaging: A Guide for Clinicians is designed to provide a foundation of information necessary for those wishing to integrate brain imaging into their practice, or to those who currently review brain scans but have minimal formal training in neuroimaging. The guide covers a range of topics important to those using brain imaging, such as the strengths and weaknesses of the many different techniques currently available, the factors that may influence the use of imaging data, common pitfalls or artifacts that may be misleading to the clinician, the most appropriate techniques to use given a specific clinical question or condition, how to interpret information presented on a brain image, and also how many pathological conditions appear on a variety of brain scanning techniques or sequences. This guide also provides detailed information regarding the identification of primary brain regions, anatomical structures, systems or pathways using both two-dimensional and three-dimensional imagiTrade ReviewThis well written and eminently readable book fills the gap between the student or practitioner with a rudimentary understanding of brain imaging techniques and the complex knowledge required by specialists. Rather than over simplify, the book focuses on what is necessary to understand these techniques in the context of clinical usefulness. ... This book provides the reader with the ability to understand the usefulness and limitations of brain imaging so that studies may be ordered appropriately with a clinical question in mind and not just as an indiscriminate screening tool. * H. Terry Hutchison, M.D., Ph.D., University of California, San Francisco - School of Medicine *Table of ContentsPreface ; Acknowledgments ; Introduction ; 1: THE CLINICAL APPLICATION OF BRAIN IMAGING ; Access to Brain Imaging ; Advantages of Using Brain Imaging in the Clinic ; Clues Regarding Extent of Injury ; Clues Regarding Type of Injury ; Clues to Location of Injury or Pathology ; Clues Regarding Prognosis and Expected Functional Outcome ; Clues Regarding Time Course for Recovery ; Concrete Information for Families ; Limitations: What Neuroimaging Often Does Not Provide the Clinician ; Brain imaging does not measure a patient's functioning ; Brain imaging may not provide information about electrochemical processes ; Brain imaging does not provide direct visualization of microscopic injury ; Brain scans often do not provide information regarding the etiology of damage ; Brain scans do not treat the patient ; Showing Damage on Brain Images May Not be Recommended ; What to Do When the Patient or Family Members Ask to See the Brain Scans ; What to Request When Writing Orders for Brain Imaging ; Radiologist Reports ; Anatomy versus Functioning ; 2: VIEWING AND INTERPRETING BRAIN SCANS ; Orientation and Image Plane ; Axial or Horizontal Orientation ; Axial Reformatting with Varying Slice Angles ; Coronal Orientation ; Sagittal Orientation ; When Right Is Left and Left Is Right ; Basic Clinical Interpretation ; Appearance of Brain Tissue on Different Types of Brain Scans ; Interpreting Findings on a Variety of Scans ; Use several image types or sequences when assessing for pathology ; Know what to look for, but also be conservative in your interpretation ; Symmetry as a Guide to Interpreting Brain Scans ; Evaluating Head Position in the Scanner ; Exercise caution when using symmetry as a guide ; Ventricular Dilation and Compression ; How much ventricular dilation can a person sustain without symptoms? ; Obstructive (Noncommunicating) Hydrocephalus ; Communicating Hydrocephalus ; Normal-Pressure Hydrocephalus ; (Hydrocephalus ex vacuo) ; Transependymal Edema ; Ventricular Asymmetry ; Steroid Use ; Guide to General Appearance of Different Tissues on Brain Images ; Developmental Changes Evident on Neuroimaging ; Myelination ; Temporal Eff ects on Appearance of Brain Scans ; Use caution when assessing atrophy ; Temporal Eff ects due to Progression of an Illness ; Know what the imaging should look like before viewing it ; Diagnostic Pitfalls of Neuroimaging ; Being too Focused or Not Focused Enough ; Missing What Is Missing ; Missing Pathology in the Neutral Gray ; Stop Searching After Finding an Obvious Abnormality ; Consider All Possible Causes for a Particular "Pathological" Appearance ; Pitfalls of Knowing the Neuropathology and Anatomy of the Injury ; Quality of Brain Imaging ; DICOM Viewers ; Comparing Scans Acquired on Different Occasions ; Presentation of Simultaneous Images ; 3: IMAGING-BASED NEUROANATOMY ; Primary Anatomical Landmarks ; Ventricles ; Meningeal Layers ; Dura and Dural Reflections (Folds) ; Dural Venous Sinuses ; Arachnoid Layer ; Pia Mater ; White-Matter Pathways ; Centrum Semiovale ; Corpus Callosum ; Cingulum ; Corona Radiata ; Internal Capsule ; Optic Tract and Radiations ; Basic Anatomical Areas of the Brain ; Forebrain ; Telencephalon ; Mesencephalon ; Midbrain ; Hindbrain ; Vascular System ; Internal Carotid and Vertebral Artery Distributions to the Cortex ; Circle of Willis ; Watershed Area ; Appendix 3-1 ; 4: BRAIN IMAGING TECHNIQUES ; Image Quality ; Spatial Resolution ; Contrast Resolution ; Noise ; What Type of Scan to Use? ; Types of Imaging ; Static Brain Imaging ; Ultrasound ; Computer Axial Tomography (CAT/CT) ; Angiography/Digital Subtraction Angiography (DSA) ; Magnetic Resonance Imaging (MRI) ; Hybrid Brain Imaging ; Diffusion-Weighted MRI (DWI) ; Diffusion Tensor Imaging-Fractional Anisotropy and Tractography ; Cerebral Perfusion-Weighted MRI (PWI) ; Magnetic Resonance Spectroscopy (MRS) ; Functional Brain Imaging ; Positron Emission Tomography (PET) ; Combined Positron Emission Tomography and CT (PET-CT) or MRI (PET-MRI) ; Single-Photon Emission Computed Tomography (SPECT) ; Functional Magnetic Resonance Imaging (fMRI) ; Magnetic Encephalopathy (MEG-MSI) ; General Concerns about Clinical Use of Functional Brain Imaging ; Benefits of Using Multiple Functional Imaging Techniques for Each Patient ; 5: NEUROIMAGING OF TRAUMATIC BRAIN INJURIES ; Focal Injury, Diffuse Injury, or a Combination? ; Post-Traumatic Hemorrhages ; Epidural Hemotoma/Hemorrhage (EDH) ; Subdural Hematoma/Hemorrhage (SDH) ; Examples of Subdural Hematomas/Hemorrhages ; Subarachnoid Hematoma/Hemorrhage ; Examples of Subarachnoid Hematomas/Hemorrhages ; Intraparenchymal Hemorrhages ; Petechial Hemorrhages ; Diff use Axonal Injury ; Hemorrhagic Contusions ; Contrecoup Injuries ; Common Locations for Hemorrhagic and Nonhemorrhagic Contusions ; Subcortical Hemorrhages ; Post-Traumatic Pneumocephalus ; Post-Traumatic Hypoxic Ischemic Encephalopathy ; Laminar Necrosis due to Hypoxic Ischemic Infarction ; Second-Impact Syndrome ; Intraventricular Hemorrhages ; Post-Traumatic Vasospasm ; Intracerebral Edema ; Midline Shift and Asymmetrical Compression the of Ventricles ; Loss of Gray-White Differentiation ; Blast Injuries ; Imaging Changes over Time Following SevereTraumatic Brain Injury ; Penetrating Injuries ; Penetration by Bone or Debris ; Gunshot Wounds ; Low-Velocity Penetrating Injuries ; High-Velocity Penetrating Injuries ; Shotgun Injuries ; Nonaccidental Trauma (NAT) ; Suspected Nonaccidental Trauma but Not Nonaccidental Trauma ; 6: NONTRAUMATIC BRAIN INJURIES ; Infections of the Brain ; Meningitis ; Encephalitis and Cerebritis ; Meningoencephalitis ; Abscess ; Empyema ; Stroke and Vascular Pathologies ; Imaging Nontraumatic Hemorrhagic Strokes-Cerebral Vascular Accident (CVA) ; Hemorrhagic Cavernomas ; Bleeding Disorders Resulting in Spontaneous Hemorrhage ; Nonhemorrhagic and Embolic Ischemic Strokes ; Blockage of Venous Flow ; Loss of Internal Carotid Flow Without Stroke-Related Symptoms ; Diffuse Hypoxic Encephalopathy ; Watershed Infarctions ; White-Matter Disorders ; Multiple Sclerosis (MS) ; Acute Disseminated Encephalomyalitis (ADEM) ; Toxic Damage to White Matter ; Neoplasm ; Diffuse, Infiltrating, and Nonenhancing Tumor ; Diffuse, Infiltrating, and Contrast-Enhancing Tumor ; Encapsulated Nonenhancing Cystic Tumor ; Encapsulated Contrast-Enhancing Tumor ; Hydrocephalus due to Tumor Growth ; Neurodevelopmental Disorders ; Cortical Dysplasia ; Agenesis of the Corpus Callosum (ACC) ; Polymicrogyria ; Anencephaly ; Holoprosencephaly ; Schizencephaly ; Multiple Neurodevelopmental Conditions ; Parasitic Disorders ; 7: BRAIN ATLAS ; Index ; Index of Clinical Examples

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Book SynopsisAlzheimer''s disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical nTrade ReviewA 'must-read,' very timely, comprehensive interdisciplinary overview illuminating the complexity of the dementia syndromes, particularly Vascular-Alzheimer spectrum disorders." -Sandra E. Black, Professor of Medicine (Neurology), Department of Medicine, Sunnybrook HSC and University of TorontoThis remarkable volume brings us the most current understanding on the undeniable role of vascular disease risk factors in both neurodegenerative and vascular dementias. Expert authors fittingly also focus on prodromal phases of the most common dementia types including mild cognitive impairment and vascular cognitive impairment. They highlight vascular disease that robustly influences relevant neuropsychological, neuroimaging as well as neuropathological substrates of dementia syndromes." -Raj Kalaria, Professor of Cerebrovascular Pathology (Neuropathology), Newcastle UniversityThere is an increasing realization that the most common neuropathology underlying dementia and MCI is the combination of plaques, tangles, as well as alterations due to vascular disease. In this important book Libon, Lamar, Swenson, and Heilman have assembled an impressive set of contributors to describe the mechanisms, markers, and treatment implications of combined AD and vascular pathology commonly present in dementia and MCI. This endeavor stands to advance our knowledge and shift current research and clinical paradigms that study neurodegenerative illness." -Glenn Smith, Chair of Psychology, University of FloridaIn this book, world-leaders in the area summarize current knowledge on the heterogeneity of Alzheimer's disease, vascular dementia, and mild cognitive impairment, and how these conditions are on a continuum and influence and shape the expression of each other. This book is a must for researchers, clinicians, and others interested in the heterogeneity and overlap of the most common forms of cognitive decline, and will be a standard reference for many years." -Ingmar Skoog, Professor, Institute of Neuroscience and Physiology and Director of the Centre for Ageing and Health, AgeCap, University of Gothenburg, SwedenTable of ContentsPreface Part 1: Epidemiology and Neuropsychology Chapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart Study Chapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum Dementia Chapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's Disease Chapter 4: Vascular Cognitive Impairment Chapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological Perspective Chapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling Techniques Chapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing Diseases Part 2: Neuroimaging Chapter 8: Cerebral small vessel disease and the risk of dementia and cognition decline Chapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuff Chapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular Dementia Part 3: Blood-Brain-Barrier and Cardiogenic Mechanisms Chapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's Disease Chapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's Disease Chapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment & Dementia Part 4: Neuropathological and Neurophysiological Mechanisms Chapter 14: Neuropathology of AD/ VaD Dementia Chapter 15: Potential of blood- and CSF-based biomarkers for AD diagnostics Chapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the Puzzle Part 5: Treatment and Intervention Chapter 17: Dementia and Elective Surgeries: Considerations for Neuropsychologists Chapter 18: Management of Mild Cognitive Impairment

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Book SynopsisManagement of Sleep Disorders in Psychiatry provides the most comprehensive and evidence-based review of the clinical management of DSM-V based sleep-wake disorders in patients with psychiatric disorders. This book is organized into three sections that focus on the basics of sleep medicine, clinical features and treatment of DSM-V sleep-wake disorders, and evidence-based management of sleep disorders commonly associated with a range of DSM-V based psychiatric disorders. The first section orients the reader to topics such as sleep physiology, neural mechanisms of wakefulness and sleep, circadian rhythms, effects of sleep on cognition, history taking in sleep medicine, and clinical application of technical procedures used in the field of sleep medicine. The second section adopts a unique perspective of using DSM-V classification of sleep-wake disorders to integrate the management of sleep disorders with mainstream clinical psychiatry. This section features a comprehensive chapter on pediatric sleep-wake disorders, a topic of interest to fellows and practicing clinicians specializing in child and adolescent psychiatry. The third section offers the most comprehensive review of comorbidity, shared pathophysiology, and clinical management of sleep disorders within the context of a wide range of DSM-V based psychiatric disorders. This section also highlights important topics such as delirium, neurocognitive disorders, effects of psychotropic medications on sleep, neurological disorders, pain disorders, forensic sleep medicine, and eating disorders. This clinically-oriented resource provides case vignettes and clinical pearls to illustrate the diagnosis and treatment of sleep disorders in the setting of a variety of psychiatric presentations. Additionally, each chapter includes a self-assessment section with multiple-choice questions that helps the reader solidify their clinical skills and prepare for the board and certification examinations for topics pertinent to sleep-wake disorders in psychiatry.Table of ContentsIntroduction to Sleep Medicine 1) Sleep Medicine and Psychiatry: The Inseparable Two 2) Sleep Architecture and Physiology 3) Neurobiology of Sleep and Wakefulness 4) Circadian rhythms 5) Sleep and Cognition 6) Office based Evaluation of Sleep Disordered Patients 7) Clinical Applications of Technical Procedures in Sleep Medicine Sleep-Wake Disorders 8) Insomnia disorder-Pathophysiology 9) Insomnia disorder- Pharmacological treatments 10) Insomnia disorder- Behavioral Treatments 11) Hypersomnolence disorders 12) Parasomnias 13) Circadian rhythm Sleep-Wake disorders 14) Sleep-Related Movement Disorders 15) Breathing-Related Sleep Disorders 16) Pediatric sleep-wake disorders Sleep and Psychiatric disorders 17) Depressive Disorders 18) Bipolar and Related Disorders 19) Anxiety Disorders 20) Trauma and Stressor-Related disorders: 21) Schizophrenia Spectrum and Other Psychotic disorders 22) Substance-Related and Addictive Disorders 23) Neurodevelopmental disorders 24) Delirium 25) Neurocognitive Disorders 26) Neuropsychiatric disorders 27) Pain Disorders 28) Psychotropic medications and Sleep 29) Forensic Sleep Medicine 30) Eating Disorders 31) Future of Sleep Medicine and Psychiatry

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Book SynopsisWidely acclaimed when it first published in 1981, this book has been brought up-to-date with this second edition. Topics covered include synaptic sources, electrode placement, choice of reference, volume conduction, power and coherence, projection of scalp potentials to dura surface, dynamic signatures of conscious experience, and neural networks immersed in global fields of synaptic action.Trade ReviewFrom reviews of the first edition:An exceptionally well-written book that will be a useful reference for researchers, clinicians, and educators alike. * Medical Physics *This volume fills an urgent need. It brings together the encephalographer and the physicist and enlightens both. It belongs on the bookshelf of anyone working in the broad and burgeoning field of neuroscience. Reginald G. Bickford is fully justified when he predicts in a brief foreword that the book will become a classic in the field. * Physics Today *Has considerable value in its presentation of clinical, theoretical, and speculative information regarding electrical potentials developed in the brain and their recording... a substantive addition to the library of the physician or scientist. * JAMA *Unique and important for a number of reasons, the most compelling of which is that for the first time a physicist with much practical experience with EEGs has set out to 'tell the whole EEG story'... a fine reference suitable as a textbook for a graduate level course on the EEG in a physiology or engineering department. Clinical neurologists specializing in epilepsy will find chapter six on EEG recording... and chapter seven on EEG analysis most valuable. The practical discussion on the choice of a reference electrode... is itself worth many times the price of the book. * Alan S. Gevins in Epilepsia *Table of ContentsAPPENDICES

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Book SynopsisWritten by a multi-disciplinary team of experts in neurobehaviour, this concise, well-illustrated book provides long-awaited normative data on clock drawing from ages 20 to 90 years.A practical guide to the quantitative assessment of clock drawing, it also takes a process-oriented approach to qualitative impairment. The authors discuss clock drawing as a neuropsychological test instrument and the rationale for selecting specific time settings, as well as the basis for using different clock conditions.The book contains numerous examples of clocks drawn by patients with cognitive impairment due to dementia, metabolic encephalopathy, traumatic brain injury, disconnection syndrome and focal brain lesions. Insight into changes in clock drawing ability that may represent the earliest markers of cognitive decline in dementia are also presented. This volume will be of interest to clinicians and researchers in neuropsychology, neurology, psychiatry, geriatric medicine, language therapy, and occTrade ReviewThis book is beautifully produced. It is full of excellent examples of clock drawings illustrating the points made in the text. The bibliography is complete and up-to-date. The book is reasonably priced and can be highly recommended to both clinicians and researchers interested in the elderly, and in patients with specific neurological disorders, focal brain lesions, and different forms of dementia. * Hans F. Reichenfeld, Journal of Psychiatry & Neuroscience, Vol. 20, No. 2 1995 *Table of ContentsIntroduction ; 1. Normative study ; 2. Dementia and related disorders ; 3. Well elderly in senior's residence ; 4. Focal brain damage

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Book SynopsisThis book provides the best available account of the life and contributions of Jean-Martin Charcot. It gives a fascinating picture of the man and his milieu, and clearly defines his role in establishing the new medical speciality of clinical neurology.Trade ReviewThe authors have achieved a detailed and balanced synthesis of many points of view derived from all available sources. * Marcus Jacobson, Nature, Vol 381, June 1996 *Table of Contents'n 1Education of a Physician 2: The Struggle for a Career in Paris Medicine 3: The Development of a Career in Neurology 4: Charcot's Major Neurological Interests 5: Charcot and the Artistry of Neurological Practice 6: Hysteria 7: Fame 8: Charcot's Private Life 9: Charcot's Death and Legacy

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Book SynopsisDetails a computational approach to studying the intricate workings of the human brain. Focusing on the brain's enigmatic ability to access quickly a massive store of accumulated information during reasoning processes, the author asks how such feats are possible.Trade ReviewThe book is written in a clear style, with a sufficient number of figures illustrating the algorithms. . .This new insight into complex problems of the brain, as well as the proposed methodology, makes the book highly readable and interesting. * Computing Reviews *The author shows that the proposed neuroidal model supports the cognitive activities he identifies. It provides a good structure to explore the functions of the mind still further. * IIEEE Spectrum *Although there are many books today dealing with a simple neuronal model based on the weighted sum principle, this one rises above these others in providing an explanation of cognitive functions. * Choice *Delivers what its title promises, and more: an engaging, broad, thorough, and often deep, development of undergraduate complex analysis and related areas (non-Euclidean geometry, harmonic functions, etc.) from a geometric point of view. The style is lucid, informal, reader-friendly, and rich with helpful images (e.g., the complex derivative as an "amplitwist"). A truly unusual and notably creative look at a classical subject. * American Mathematical Monthly *Table of Contents1. The Approach ; 2. Biological Constraints ; 3. Computational Laws ; 4. Cognitive Functions ; 5. The Neuroidal Model ; 6. Knowledge Representation ; 7. Unsupervised Memorization ; 8. Supervised Memorization ; 9. Supervised Inductive Learning ; 10. Correlational Learning ; 11. Objects and Relational Expressions ; 12. Systems Questions ; 13. Reasoning ; 14. More Detailed Neural Models ; 15. Afterword

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Book SynopsisNeurology abounds with eponyms. This book brings together 55 eponyms related to neurological examination, neuroanatomy and neurological diseases. For each it provides a short biography, a discussion of the original publication, and a discussion of the evolution and significance of the eponym.Trade Review"...a beautiful book describing the origin and clinical neurosciences...The editors' goal for this book was education and entertainment. They have succeeded quite admirably."--New England Journal of Medicine Noted in Nature "This book opens a valuable window on interesting people...Neurologists, neurosurgeons, neuroscientists, internists, and other generalists with an interest in the history of neurology would probably enjoy it."--JAMA2001 "The editors' goal for this book was education and entertainment. They have succeeded quite admirably."--New England Journal of MedicineAugust 2001 "...both educational and entertaining...By any account, this book is a success and can be warmly recommended."--Ian McDonald in BRAINTable of ContentsPART I STRUCTURES AND PROCESSES; PART II SYMPTOMS AND SIGNS; PART III REFLEXES AND OTHER TESTS; PART IV SYNDROMES; PART V DISEASES AND DEFECTS

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Book SynopsisStimulant drugs are widely used in the treatment of ADHD in children and adults, yet their mechanism of action have been poorly understood. This volume integrates advances in the basic and clinical neurosciences in order to shed light on this question.Trade Review"This book is an ambitious, even courageous, attempt to pull together evidence from the basic and clinical neurosciences that may ultimately help explain how stimulant drugs act to reduce the behavioral and cognitive symptoms associated with attention-deficit-hyperactivity disorder (ADHD)." --Contemporary Psychology "This book is an ambitious, even courageous, attempt to pull together evidence from the basic and clinical neurosciences that may ultimately help explain how stimulant drugs act to reduce the behavioral and cognitive symptoms associated with attention-deficit-hyperactivity disorder (ADHD)." --Contemporary Psychology "...a volume that will interest almost anyone who works with attention deficit hyperactivity disorder (ADHD) in either clinics or research programs"--The Journal of Nervous and Mental Disease "...a timely addition to the ever growing literature on the most controversial of pharmacotherapies for children and adolescents...most of the chapters are engaging....The clinical chapters by Mary Solanto(on the clinical features of ADHD), Laurence Greenhill(on the clinical effects of stimulant medication), and the final, challenging chapet by Solanto, Amy Arnsten, and Xavier Castellanos are outstanding."--The Lancet, 2001 "This slender volume is an excellent collection of reviews on ADHD in the context of modern psychopharmacology and neuroscience....The quality of all the chapters is consistently of a very high standard, each text a gem on its own. They are concisely written and densely packed with relevant information. The materials are accessible, despite being technical in nature...a superb set of essays....Overall, this is--and I believe will remain for some time--a benchmark publication, relevant to any clinician who prescribes ADHD psychopharmacological treatment, and to investigators in ADHD research from medical or neuroscience backgrounds alike."--Journal of Child Psychology and PsychiatryTable of ContentsPART I: PHENOMENOLOGY; PART II: BASIC NEUROSCIENCE; PART III: CLINICAL NEUROSCIENCE; PART IV: INTEGRATION

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Book SynopsisThis reference text provides an insightful and unified synthesis of cognitive neuroscience and behavioral neurology. The strong clinical emphasis and outstanding illustrations will provide neurologists, psychiatrists, neuropsychologists, and psychologists with a solid foundation to the major neurobehavioral syndromes. With backgrounds in behavioural neurology, functional imaging and cognitive neuroscience, the two authors are in an ideal position to cover the anatomy, genetics, physiology, and cognitive neuroscience underlying these disorders. Their emphasis on therapy makes the book a must read for anyone who cares for patients with cognitive and behavioural disorders.Trade Review. . . part of the highly regarded Contemporary Neurology Series, and it carries on the tradition of excellence neurologists have come to expect of these volumes . . . The writing style is concise, clear, readable. Clinical vignettes and example cases, drawn both from the authors' experience and the published literature, reinforce important concepts . . . Devinsky and D'Esposito have broken new ground with a fresh approach to the neurology of cognition and behavior . . . * Neurology *The latest in the "Contemporary Neurology Series", Neurology of Cognitive and Behavioural Disorders, is a comprehensive, authoritative, and practical tome for clinicians, as a stand-alone reference and as an entertaining way of using the time allocated for those outpatient no-shows . . . This book should appeal to a wide range of neuroscience subspecialists, and comes with a strong recommendation to clinical neurologists from this reviewer. * The Lancet Neurology *Table of Contents1. Neuroanatomy and Assessment of Cognitive-Behavioural Function ; 2. Functional Neuroimaging of Cognition ; 3. The Right Hemisphere, Interhemispheric Communication, and Consciousness ; 4. Attention and Attentional Disorders ; 5. Perception and Perceptual Disorders ; 6. Language, Aphasia, and Other Speech Disorders ; 7. Motor System and Behaviour ; 8. Memory and Memory Disorders ; 9. Executive Function and the Frontal Lobes ; 10. Emotion and the Limbic System ; 11. Therapy for Cognitive and Neurobehavioral Disorders

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Book SynopsisMost of what has been learned about how the brain mediates behaviour comes from experiments of nature where a stroke or other damage to the brain produces changes in a person''s behaviour. In Matter of Mind, one of the leading figures in behavioural and cognitive neurology uses patient vignettes and other examples from his rich professional life to show just how much knowledge about brain functions such as reading, writing, language, control of emotions, skilled movement, perception, attention, and motiviation has been gained from the study of patients with diseases of or damage to the brain. No knowledge of neurology or neuroscience is required to understand the book, which is intended for neurological patients and their families. It will also be of interest to professionals who study the brain or treat patients with brain damage including neuropsychologists, neurologists, neuroscientists, psychologists, speech pathologists, occupational and physical therapists, and their students andTrade ReviewFor those fascinated by neurobehavioural syndromes and how the disordered mind can be understood from intensive observation and experimental deduction . . . [this book] offers an important perspective . . . an adventurous romp through the modern history of behavioural neurology . . . fosters an appreciation for the intricacies and subtlety of brain-behaviour relationships. The information is presented in a way a layperson can understand, and a neurologist, young or mature, can relish. * Neurology Today *This is a book intended for general public readership. It is surely going to be enjoyed by readers with interest in how the brain works and, specifically, in the relationship between brain and mind, even if they do not have a specific knowledge in neurology. The book is timely, trying to fill up some of the remaining gaps in the ever-growing scientific study of behaviour, emotions, cognition, and other similar human brain mediated functions . . . It is well written in an easy-to-read conversational tone that makes the very complex mind matters understandable, and attractive, to the non-specialized reader. * Clinical Neurophysiology, 114 *Table of Contents1: Introduction 2: Language-Cognition Speech - Reading - Writing 3: Emotion Emotional Communication - Emotional Experience 4: Attention 5: Self-Awareness 6: Memory 7: Motor Skills 8: Sensory Perception 9: Conation-Intention

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Book SynopsisTells the story of how long-standing notions about the body as dominated by spirit-like humors were transformed into scientific descriptions of its solid tissues. This book shows how debates over investigative methods and models of body order influence biomedicine and the broader culture.Trade ReviewAdvance Praise for The Brain Takes Shape:Scholars often pay lip service to the important roles of theological and philosophical concepts in the making of modern science and medicine. Robert Martensen has taken the platitude seriously, and his book powerfully demonstrates how our modern beliefs about mind and body were first elaborated in the seventeenth century, when philosophy, theology and science were intertwined. The result is a cultural history of biomedicine at its very best. * W.F. Bynum, Wellcome Trust Centre for the History of Medicine, University College London *Table of ContentsSelected events and historical actors ; 1. Bodies, words, and images ; 2. Matter, spirit, and the heart ; 3. The human mind and "Gland H": Cartesian models of mind, brain, and nerves ; 4. When the brain came out of the skull ; 5. Body of witnesses ; 6. Toward a new physiology of human conduct ; 7. The transformation of Eve ; 8. Mind without brain: John Locke, Thomas Syndenham, and the constitutional body of the British enlightenment ; 9. On the persistence of the cerebral body and its alternatives

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Book SynopsisIt is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies os synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases.Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioural and gene-targeting methods. Leading experts in the best understood brain regions bring toTrade ReviewThis fifth edition of Shepherd's well-respected text is still worth having on the bookshelf . . . the regions covered are dealt with systematically and clearly. Each chapter has a similar structure, with sections on the neuronal elements present, their synaptic connections and basic circuits, their intrinsic membrane properties, synaptic actions and dendritic properties, and the functional properties of the circuits. This is all done clearly and thoroughly, packing a great deal of information into a small space . . . The synaptic organisation of the brain is a classic text, and still very much worth having and reading for anyone interested in the details of neuroscience. * Physiology News, Number 56 *Table of Contents1. Introduction to Synaptic Circuits ; 2. Membrane Properties and Neurotransmitter Actions ; 3. Spinal Cord: Ventral Horn ; 4. Cochlear Nucleus ; 5. Olfactory Bulb ; 6. Retina ; 7. Cerebellum ; 8. Thalamus ; 9. Basal Ganglia ; 10. Olfactory Cortex ; 11. Hippocampus ; 12. Neocortex

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Book SynopsisThe Vestibular System is an integrative look at the vestibular system and the neurobiology of balance.Trade ReviewCompelling and timely, this book offers a comprehensive and authoritative survey of current vestibular science... an outstanding reference that will likely find its way into the offices of basic scientists and clinicians alike... The authors have done a wonderful job of consolidating a broad body of current knowledge into a readable book. I highly recommend this to anyone seeking to refine their knowledge of the vestibular system. * Doody's Notes, June 2013 *Table of ContentsI. Introduction ; Chapter 1- The Vestibular System in Everyday Life ; 1.1 Overview of the vestibular system ; 1.2 Visual acuity and the vestibulo-ocular reflex ; 1.3 Air-righting reflex in the cat ; 1.4 Post-rotational reactions ; 1.5 Positional alcohol nystagmus (PAN) ; 1.6 Motion sickness ; 1.7 Vection illusions ; 1.8 The subjective visual vertical ; 1.9 Adaptive plasticity ; 1.10 Path finding and spatial orientation ; 1.11 Postural control ; 1.12 Summary ; 1.13 Selected readings ; II. Peripheral Vestibular System ; Chapter 2 - Structure of the Vestibular Labyrinth ; 2.1 Gross and microscopic anatomy ; 2.2 Fine structure of the sensory regions ; Hair cells ; Supporting cells ; Transitional regions ; 2.3 Regional variations in cellular architecture and afferent innervation ; Cristae ampullares ; Utricular macula ; Saccular macula ; 2.4 Efferent innervation ; 2.5 Summary ; 2.6 Selected readings ; Chapter 3- Hair Cell Transduction ; 3.1 Mechanoelectric transduction ; 3.2 Basolateral currents ; 3.3 Neurotransmitter release and presynaptic calcium ; channels ; Calcium channels ; Neurotransmitter release. ; 3.4 Postsynaptic mechanisms ; 3.5 Synaptic transmission involving type I hair cells ; 3.6 Spike encoding ; 3.7 Efferent neurotransmission ; 3.8 Summary ; 3.9 Selected readings ; Chapter 4- Physiology of the Vestibular Organs ; 4.1 General features of the vestibular organs ; Vestibular organs are inertial sensors ; Resting discharge ; Discharge regularity ; Information transmission ; 4.2 Semicircular canals ; Directional properties ; Macromechanics and the torsion-pendulum model ; Interspecies variations and canal dimensions ; Afferent response dynamics ; Variations in gain and phase ; Afferent morphology and physiology ; Dynamic range of afferent discharge ; 4.3 Otolith organs ; Directional properties ; Macromechanics and the otoconial membrane ; Afferent response dynamics ; Dynamic range of afferent discharge ; Variations in gain and phase ; Afferent morphology and physiology ; 4.4 Summary ; 4.5 Selected readings ; Chapter 5- The Efferent Vestibular System ; 5.1 Comparative anatomy of central efferent pathways ; 5.2 Responses of afferents to electrical stimulation of ; EVS ; Mammals. ; Non-mammals ; 5.3 Responses of efferents to natural stimulation ; 5.4 Efferent-mediated responses of afferents ; 5.5 Possible functions of efferents in mammals ; 5.6 Summary ; III. Central Vestibular System ; Chapter 6 - Neuroanatomy of Central Vestibular Pathways ; 6.1 Introduction ; 6.2 The vestibular nuclei: subdivisions and anatomical ; organization ; Medial vestibular nucleus (MVN) ; Lateral vestibular nucleus (LVN) ; Superior vestibular nucleus (SVN) ; Descending vestibular nucleus (DVN) ; y group ; Interstitial nucleus of the vestibular nerve (INT8) ; Associated cell groups (z, x, f, l,m) ; Projection and intrinsic neurons ; Connections with the ipsilateral vestibular nerve ; Commissural pathways ; 6.3 Vestibulo-ocular and optokinetic systems ; Semicircular canal projections to oculomotor neurons ; Otolith projections to oculomotor neurons ; Nucleus prepositus hypoglossi (NPH) ; Interstitial nucleus of Cajal (INC) ; Reticular formation ; Optokinetic pathways ; 6.4 Vestibulospinal systems ; Medial vestibulospinal tract (MVST) ; Lateral vestibulospinal tract (LVST) ; Vestibulo-ocular cervical pathways (VOC) ; Other vestibulospinal tracts ; Spinal projections to the vestibular nuclei ; 6.5 Vestibulocerebellar relations ; Basic circuitry ; Vestibular projections to the cerebellum ; Prepositus nucleus ; Projections from the deep cerebellar nuclei to the ; vestibular nuclei ; Projections from the cerebellar cortex to the vestibular ; nuclei ; Cerebellar cortical modules ; Lateral reticular nucleus ; Vestibulo-paramedian tract projections ; 6.6 Vestibulo-autonomic connections ; 6.7 Vestibular connections with the neocortex ; 6.8 Pathways involving the hippocampal formation ; 6.9 Summary ; 6.10 Selected readings ; 6.11 List of abbreviations ; Chapter 7 -Synaptic Mechanisms in the Vestibular Nuclei ; 7.1 Historical perspective ; 7.2 Basic circuitry of the vestibular nuclei ; Ipsilateral vestibular nerve inputs ; Commissural connections ; 7.3 Neurotransmitters in the vestibular nuclei ; Transmission between the vestibular nerve and secondary ; neurons ; Transmission within the vestibular nucleus ; Output pathways of the vestibular nuclei ; 7.4 Properties of individual neurons ; Resting discharge ; 7.5 Central projections of regular and irregular afferents ; Electrophysiological studies ; Functional ablation of irregular afferents ; 7.6 Convergence from separate vestibular organs ; Convergence from separate vestibular organs ; Canal-canal convergence ; Otolith-otolith convergence ; Spatio-temporal convergence ; Canal-otolith convergence ; Convergence from somatosensory receptors ; 7.7 Summary ; 7.8 Selected readings ; IV. Vestibulo-ocular and Vestibulopinal Mechanisms ; Chapter 8 - An Oculomotor Tutorial ; 8.1 Overview and classification of eye movement types ; 8.2 Ocular structure and functional implications ; The extraocular eye muscles. ; Mechanics of the oculomotor plant ; Oculomotor motoneuron discharge. ; Plant mechanics and premotor control. ; 8.3 Gaze Redirection ; Saccades ; Smooth pursuit ; Vergence ; 8.4 Gaze Stabilization ; Vestibulo-ocular reflexes. ; Optokinetic system. ; 8. 5 Interactions between eye and head movements ; 8.6 Summary ; 8.7 Selected readings ; Chapter 9 -Vestibulo-ocular Reflexes ; 9.1. Semicircular-canal related angular VOR (AVOR) ; General properties of the canal-related AVOR. ; AVOR during high frequency rotations. ; AVOR at low frequencies - velocity storage. ; AVOR-visual interactions: the optokinetic system. ; AVOR in three-dimensions. ; 9.2. Otolith-ocular reflexes ; Tilt VOR. ; Otolith influences on the AVOR during off-vertical axis ; rotations (OVAR). ; Otolith influences on the AVOR during canal/otolith ; conflict. ; Translational VOR (TVOR). ; Optic flow during translation. ; Visual mechanisms for short latency visual compensation ; during translation. ; Distinguishing tilts from translations. ; Differences between the AVOR and the TVOR. ; Functional differences: Foveal rather than full-field image ; stabilization. ; Dependence on viewing distance and eye position. ; Response latency and neural pathways. ; Comparative adaptation ; 9.3 Summary ; 9.4 Selected readings ; Chapter 10-The Vestibulospinal System and Postural Control ; 10.1. Reflexes versus multisensory strategies ; 10.2 Multisensory strategies ; 10.3. Vestibular reflexes: general considerations ; 10.4 Vestibulocollic reflexes ; The angular VCR. ; The linear VCR evoked by translation and tilts. ; The cervicocollic reflex ; 10.5. Control systems analysis of the head-neck plant. ; Head plant. ; Vestibulocollic reflex. ; The cervicocollic reflex ; Reflex interactions. ; Use of control systems models ; 10.6. Vestibulospinal and neck reflexes acting on the ; limbs ; Spatial and temporal properties of the reflexes. ; Afferent origin of the reflexes ; Neural substrate of the reflexes. ; Vestibulospinal actions on hindlimb motoneurons. ; Vestibulospinal actions on forelimb motoneurons. ; Tonic neck reflexes. ; 10.7 Summary ; 10.8 Selected readings ; V. Signal Processing in Alert Animals ; Chapter 11- Signal Processing in Vestibular Nuclei of Alert ; Animals During Natural Behaviors ; 11.1 Introduction ; 11.2 Classes of neurons in head-restrained, alert monkeys ; Position-vestibular-pause (PVP) neurons. ; Vestibular-only (VO) and vestibular-pause cells. ; Eye-head (EH) neurons. ; Burst-tonic (BT) neurons. ; 11.3 Dynamics of neuronal responses ; Frequency response during sinusoidal rotations ; Response linearity ; Velocity storage ; 11.4 Response to linear translations in alert ; head-restrained monkeys ; Distinguishing translational from tilt. ; 11.5 Interactions with the oculomotor pathways that control ; pursuit eye movements ; 11.6 Integration of inputs from vestibular and optokinetic ; pathways ; VN modulation during the OKR ; Optokinetic pathways to the VN. ; 11.7 Integration of vestibular and proprioceptive inputs ; 11.8 Differential processing of active versus passive head ; movements ; Neuronal responses during active versus passive head ; movement. ; Mechanisms for the differential processing of ; actively-generated versus passive head movement. ; 11.9 Vestibular processing depends on current gaze ; strategy. ; Vestibular processing during voluntary gaze shifts. ; Vestibular processing during visual tracking; VOR ; cancellation and eye-head pursuit. ; Vestibular processing during near versus far viewing. ; 11.10 Summary ; 11.11 Selected readings ; Chapter 12 - The Cerebellum and the Vestibular System ; 12. 1 Overview of signal processing in the cerebellum ; The basic cerebellar circuit ; Vestibular inputs are specific to localized regions of the ; cerebellum ; 12.2 Nodulus and Ventral Uvula ; Mossy fiber inputs. ; Climbing fiber inputs. ; Efferent connections. ; Neuronal responses ; Lesions and function. ; 12.3 Flocculus and ventral paraflocculus ; Mossy fiber inputs. ; Climbing fiber inputs ; Efferent projections of the flocculus. ; Differences between the flocculus and ventral ; paraflocculus ; Neuronal responses. ; Complex spikes: ; Simple spikes. ; Changes in neuronal responses following VOR learning ; Lesions and function ; Lesions studies emphasize the role of the flocculus in VOR ; Adaptation and motor learning ; 12.4 The Vermis of the Anterior and Posterior Lobes ; 12.5 The Deep Cerebellar Nuclei ; Fastigial Nucleus. ; Rostral fastigial nucleus ; Caudal fastigial nucleus ; The interposed nuclei. ; Dentate nuclei. ; 12.6 Summary ; 12.7 Selected Readings ; VI..Functional Considerations ; Chapter 13 - Learning and Compensation in the Vestibular ; System ; 13.1 Motor learning in the vestibulo-ocular reflex ; The adaptive capabilities of the VOR. ; Signal flow in the VOR network. ; Rules for the VOR and motor learning. ; Possible sites of motor learning: cerebellum versus brain ; stem ; Evidence for sites of learning and memory. ; Possible cellular mechanisms of synaptic plasticity ; Cerebellar mechanisms ; Brain stem mechanisms ; Consolidation of VOR motor memory ; Generalization: can learning be applied to new situations? ; 13.2. Compensation for vestibular damage ; Uninilateral labyrinthectomy ; Activity in the vestibular nuclei following ; labyrinthectomy ; Cellular mechanisms of compensation in the vestibular ; nuclei ; The role of the cerebellum in compensation ; 13.3 Summary ; 13.4 Selected readings ; Chapter 14-Cortical Representations of Vestibular ; Information ; 14.1. Introduction ; 14.2. Historical Perspective ; 14.3. Multiple representations of vestibular signals in the ; cerebral cortex. ; Visuomotor areas in frontal cortex. ; Extrastriate visual cortex (MSTd). ; Ventral intraparietal (VIP) area ; Parieto-insular vestibular cortex (PIVC), area 2v and area ; 3a ; 14.4. Ascending vestibular pathways through the thalamus ; 14.5 Descending cortical information affecting vestibular ; responsiveness in the vestibular nuclei ; 14.6. Vestibular influences in the head direction circuit of ; the limbic system ; 14.7 Summary ; 14.8 Selected readings ; Chapter 15-Reference Frames Used in the Coding Vestibular ; Information ; 15.1. Definitions of coordinate systems and reference ; frames ; 15.2. Head- versus body-centered reference frames: ; Vestibular/neck proprioceptive interactions ; 15.3. Head- versus eye-centered reference frames for ; self-motion perception: vestibular/visual interactions in ; extrastriate visual cortex ; 15.4. Head- versus world-centered reference frames: ; Canal/otolith convergence for inertial motion detection ; 15.5 Computational solution for the two ambiguities of peripheral ; vestibular sensors ; The rotation problem: allocentric coding of angular velocity ; The linear acceleration problem: evidence for segregation of ; tilt and translation ; Tilt-translation exceptions ; VII. Clinical Disorders ; Chapter 16- Clinical Manifestations of Vestibular ; Dysfunction ; 16.1 Prevalence and impact of vestibular disorders ; 16.2 Diagnosis of vestibular disorders ; 16.3 Planes of individual canals and direction of eye ; movements ; Benign paroxysmal positional vertigo ; Positional alcohol nystagmus ; Superior semicircular canal dehiscence syndrome ; 16.4 Recovery of the horizontal VOR after unilateral ; labyrinthectomy ; 16.5 Multisensory control of posture ; 16.6 Disorders of otolith function ; 16.7 Clinical tests of vestibular function ; Caloric test ; Rotational chair tests ; Quantitative evaluation of the VOR evoked by rapid head ; movements ; Vestibular-evoked myogenic potentials (VEMPs) ; 16.7 Future directions ; Hair-cell regeneration ; Vestibular prosthesis ; 16.8 Summary ; 16.9 Selected readings

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Book SynopsisFractured Minds introduces the reader to clinical neuropsychology through vivid case descriptions of adults who have suffered brain damage. At one level, this is a book about the courage, humour, and determination to triumph over illness and disability that many ordinary people demonstrate when coping with the extraordinary stress of a brain disorder. On another level, it is a well-referenced and up-to-date textbook that provides a holistic view of the practice of clinical neuropsychology. Included are reader-friendly descriptions and explanations of a wide range of neurological disorders and neuroscientific concepts.Two introductory chapters are followed by 17 chapters that each focus on a specific disorder and include research, clinical assessment, rehabilitation, and a detailed case study. Disorders range across the full spectrum from common ones such as traumatic brain injury and dementia, to rare disorders such as autopagnosia. Each of the 16 chapters retained from the first editiTrade Review"Although this book is very different than others in the field, its incorporation of the human element makes it stand out as a 'must have.' The second edition offers new chapters on multiple sclerosis, Parkinson's disease, and Huntington's disease, and improves previous chapters with new medical information and patient updates." --Doody's "Although this book is very different than others in the field, its incorporation of the human element makes it stand out as a 'must have.' The second edition offers new chapters on multiple sclerosis, Parkinson's disease, and Huntington's disease, and improves previous chapters with new medical information and patient updates." --Doody'sTable of Contents1. Introduction to clinical neuropsychology ; 2. The neuropsychological assessment ; 3. Marooned in the moment: H. M., A case of global America ; 4. Out of control: the consequences and treatment of epilepsy ; 5. The breakdown of language: case studies of aphasia ; 6. A body in the mind: a case of autopagnosia ; 7. Out of mind, out of sight: a case of hemineglect ; 8. Vision without knowledge: visual object agnosia and prosopagnosia ; 9. The impaired executive: a case of frontal-lobe dysfunction ; 10. Beating the odds: severe head injury and the importance of ongoing rehabilitation ; 11. The unseen injury: minor closed head injury ; 12. Explosions in the mind: a case of subarachnoid hemorrhage ; 13. Twenty years too late: organic solvent neurotoxicity ; 14. Tomorrow is another day: living with multiple sclerosis ; 15. Mind over matter: coping with Parkinson's Disease ; 16. Huntington's disease: a family challenged ; 17. Dementia: a family tragedy ; 18. Split brain, split mind? Case L. B. ; 19. A whole life with half a brain: Kate's story

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Book SynopsisFractured Minds introduces the reader to clinical neuropsychology through vivid case descriptions of adults who have suffered brain damage. At one level, this is a book about the courage, humour, and determination to triumph over illness and disability that many ordinary people demonstrate when coping with the extraordinary stress of a brain disorder. At another level, it is a well-referenced and up-to-date textbook that provides a holistic view of the practice of clinical neuropsychology. Included are reader-friendly descriptions and explanations of a wide range of neurological disorders and neuroscientific concepts.Two introductory chapters are followed by 17 chapters that each focus on a specific disorder and include research, clinical assessment, rehabilitation, and a detailed case study. Disorders range across the full spectrum from common ones such as traumatic brain injury and dementia, to rare disorder such as autotopagnosia. Each of the 16 chapters retained from the first editTrade Review"Although this book is very different than others in the field, its incorporation of the human element makes it stand out as a 'must have.' The second edition offers new chapters on multiple sclerosis, Parkinson's disease, and Huntington's disease, and improves previous chapters with new medical information and patient updates." --Doody's "Although this book is very different than others in the field, its incorporation of the human element makes it stand out as a 'must have.' The second edition offers new chapters on multiple sclerosis, Parkinson's disease, and Huntington's disease, and improves previous chapters with new medical information and patient updates." --Doody'sTable of Contents1. Introduction to clinical neuropsychology ; 2. The neuropsychological assessment ; 3. Marooned in the moment: H. M., a case of global amnesia ; 4. Out of control: the consequences and treatment of epilepsy ; 5. The breakdown of language: case studies of aphasia ; 6. A body in the mind: a case of autotopagnosia ; 7. Out of mind, out of sight: a case of hemineglect ; 8. Vision without knowledge: visual object agnosia and prosopagnosia ; 9. The impaired executive: a case of frontal-lobe dysfunction ; 10. Beating the odds: severe head injury and the importance of ongoing rehabilitation ; 11. The unseen injury: minor closed head injury ; 12. Explosion in the mind: a case of subarachnoid hemorrhage ; 13. Twenty tears too late: organic solvent neurotoxicity ; 14. Tomorrow is another day: living with Multiple Sclerosis ; 15. mind over matter: coping with Parkinson's disease ; 16. Huntington's disease: a family challenged ; 17. Dementia: a family tragedy ; 18. Split brain, split mind? Case L. B. ; 19. A whole life with half a brain: Kate's story

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Book SynopsisScientists'' understanding of two central problems in neuroscience, psychology, and philosophy has been greatly influenced by the work of David Hubel and Torsten Wiesel: What is it to see? This relates to the machinery that underlies visual perception, How do we acquire the brain''s mechanisms for vision? This is the nature-nurture question as to whether the nerve connections responsible for vision are innate or whether they develop through experience in the early life of an animal or human.This is a book about the collaboration between Hubel and Wiesel, which began in 1958, lasted until about 1982, and led to a Nobel Prize in 1981. It opens with short autobiographies of both men, describes the state of the field when they started, and tells about the beginnings of their collaboration. It emphasizes the importance of various mentors in their lives, especially Stephen W. Kuffler, who opened up the field by studying the cat retina in 1950, and founded the department of neurobiology at HaTrade Review...charming and interesting autobiographical essays. * Alva Noe, TLS *Extremely important * Alva Noe, TLS *All in all this is an excellent book and helps to set the work of Hubel and Wiesel in the context of real people doing real science. It also helps to connect the papers together in an appropriate set of sequences for those starting in the area - how it would have helped to have it around when I first started trying to teach visual physiology to medical students * Physiology News, No 61 *The entire book is an inspiration to read. The original papers and the additional chapters are beautifully written - which means that they are stylistically elegant, free from jargon and cliche and, above all, devoid of the current, vulgar, craze for acronyms and abbreviations and of other devices that serve to make science even more inaccessible . . . Neuroscience should rejoice that, during a mere 25 years, its world was enriched not only by a wealth of knowledge but also by new standards of evidence and elegance of methodology which have left a permanent imprint. * Brain, 128 *The book's glory is that the commentaries sandwiching each paper illuminate the workings of one of the most productive collaborations in the history of biology. Hubel and Wiesel describe the joy of mom-and-pop science where the collaborators do the work and weigh what to do next . . . the book brings their work all together - complete with the authors' retrospective evaluations of their work . . . a gem in the history of the field and a core resource. * Robert Wurtz in Science *. . . The entire book is an inspiration to read. The original papers and the additional chapters are beautifully written . . . Read today, some 50 years after the initial work was published, the papers still retain their freshness and their capacity to arouse wonder, not only at the way in which nature has elaborated such an impressive organ, but also at the tenacity and the powerful conceptual thinking that was behind their collected work . . . Neuroscience should rejoice that, during a mere 25 years, its world was enriched not only by a wealth of knowledge but also by new standards of evidence and elegance of methodology which have left a permanent imprint. * Semir Zeki in Brain *Advance praise for Brain and Visual Perception:For those who came of age admiring the scientific adventures of Hubel and Wiesel, this book is an opportunity to look back in wonder. For those who came after, it will be an inspiration. This is a marvel of a book, written in David Hubel's disarmingly engaging voice, a must have, a must read. * Antonio Damasio, Neuroscientist and author of Descartes' Error and Looking for Spinoza *David Hubel and Torsten Wiesel's book describes the wonderful period in neurophysiology when they worked on the early mammalian visual system. I found it fascinating reading. * Francis Crick, Nobel Laureate and author of The Astonishing Hypothesis and What Mad Pursuit *A rare opportunity to peek into the minds of two giants of twentieth century science. Each of their classic papers reads like a Sherlock Holmes novel, but the accompanying commentaries and autobiographies, packed with witty, whimsical asides and Hubelisms, bring out the human side of science - reminding us that great science is a judicious blend of intuition, imagination and sheer tenacity rather than a cold rational process of the kind one usually associates with Holmes. It's especially refreshing to see their low-tech approach in an era of high-tech 'big science' dominated by brain imaging and gee whiz neophrenology. * V S Ramachandran, BBC Reith Lecturer for 2003 and author of A Brief Tour of Human Consciousness *Hubel and Wiesel, as much as any other scientists, are responsible for our current view of the brain, its function, and how it is moulded by the environment. This book will provide students and established scientists alike insight into the roots of modern neuroscience, a view into one of the most productive collaborations in the field, and some of the best examples of scientific writing in the literature. * David Ferster, Professor of Neurobiology and Physiology, Northwestern University, USA *Beginning around 1960, David Hubel and Torsten Wiesel took the study of the brain and its development from the realm of philosophy to biology. These papers and the commentaries that accompany them put the reader inside the heads of the scientists who gave us our modern understanding of the cerebral cortex, often by asking the next logical question, but always with appreciation for the beauty of the system. * Michael P. Stryker, W.F. Ganong Professor of Physiology, University of California, San Francisco, USA *Table of ContentsPART I: INTRODUCTION AND BIOGRAPHIES; PART II: BACKGROUND TO OUR RESEARCH; PART III: NORMAL PHYSIOLOGY AND ANATOMY; PART IV: DEPRIVATION AND DEVELOPMENT; PART V: THREE REVIEWS

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Book SynopsisThe field of social cognitive neuroscience has captured the attention of many researchers during the past ten years. Much of the impetus for this new field came from the development of functional neuroimaging methods that made it possible to unobtrusively measure brain activation over time. Using these methods over the last 30 years has allowed psychologists to move from simple validation questions -- would flashing stimuli activate the visual cortex -- to those about the functional specialization of brain regions-- are there regions in the inferior temporal cortex dedicated to face processing-- to questions that, just a decade ago, would have been considered to be intractable at such a level of analysis. These so-called intractable questions are the focus of the chapters in this book, which introduces social cognitive neuroscience research addressing questions of fundamental importance to social psychology: How do we understand and represent other people? How do we represent social grTrade ReviewTodorov, Fiske and Prentice have assembled the leading figures of the nascent field of social neuroscience in a volume that is rich with ideas and the data to support them. Using data from brain lesions, EEG, and fMRI, the authors consider how brain systems are organized to support social behavior. The text considers brain systems involved in issues such as racism and dehumanized perception, the distinction between thinking about the self and about others, self-regulation and the symbolic processing of affect, emotional decision making, the components of trustworthiness in face perception, and the fate of the soul. This book is very accessible and will appeal to a broad audience that includes scientists within related fields of psychology and neuroscience, but also non-experts who are interested in how social behavior is organized in the brain. --Gregory McCarthy, Professor of Psychology, Yale University "Social Neuroscience has revolutionized how people think about social behavior. In a collection of compelling rigorous essays, the leading experts lay out the foundations of this exciting new field. This is the cutting edge of science." --Shelley E. Taylor, Distinguished Professor, Department of Psychology, University of California, Los Angeles "Social Neuroscience provides an up-to-date survey of key themes and findings, focusing on cognitive neuroscience studies in humans. Contributions from many of the major players in the field cover topics ranging from face perception, to stereotyping and bias, to regulation, decision-making and moral judgment. Especially valuable are brief synthetic commentaries at the end of each section. The volume will be an accessible introduction for upper-level undergraduates and graduate students, and a valuable reference source for all investigating human social cognition. Importantly, the contributions all convey the excitement of the field and point to future studies, fuel for motivating the next generation of young scientists in social neuroscience." --Ralph Adolphs, Professor of Psychology and Neuroscience, California Institute of Technology "Social Neuroscience: Toward Understanding the Underpinnings of the Social Mind is an informative and valuable resource for a diverse audience and various professional fields- including social psychology, neuroscience, anthropology, medicine, political science, economics, and philosophy- as well as for laymen with an ardent interest in biophilosophical inquiry." -- Sigmund Hough, PhD, ABPP, Assistant Professor, Psychiatry at Harvard Medical School; Maggi Budd, PhD, MPH, ABPP, Instructor in the Department of Psychiatry, Harvard Medical School; PsychCRITIQUESTable of ContentsIntroduction - A. Todorov, S. T. Fiske, and D. Prentice I. Understanding and representing other people 1. How has cognitive neuroscience contributed to social psychological theory? - Adrianna C. Jenkins & Jason P. Mitchell (Harvard University) 2. You, me, and my brain: Self and other representations in social cognitive neuroscience - Jamil Zaki and Kevin Ochsner (Columbia University) 3. Distributed processes for retrieval of person knowledge - M. Ida Gobbini (University of Bologna, Italy) 4. Evaluating faces on social dimensions - Alexander Todorov (Princeton University) 5. Commentary: Social neuroscience and the representation of others - James V. Haxby (Princeton University) II. Understanding and representing social groups 6. Perceiving social category information from faces: Using ERPs to study person perception - Tiffany A. Ito (University of Colorado, Boulder) 7. Multiple mechanisms for regulating of intergroup bias: Contributions from social neuroscience - David M. Amodio (New York University) 8. Perceiving humanity - Lasana T. Harris and Susan Fiske (Princeton University) 9. Commentary: Us versus them: The social neuroscience of perceiving outgroups - Nalini Ambady & Reginald Adams(Tufts University) III. Regulation of social behavior 10. Self-regulation and evaluative processing - Dominic J. Packer, Amanda Kesek (University of Toronto) & William A. Cunningham (The Ohio State University) 11. The neural basis of emotional decision-making - Jennifer S. Beer & Jamil P. Bhanji (University of California, Davis) 12. Social neuroscience of asymmetrical frontal cortical activity: Considering anger and approach motivation - Eddie Harmon-Jones & Cindy Harmon-Jones (Texas A&M University) 13. Why symbolic processing of affect can disrupt negative affect: Social cognitive and affective neuroscience investigations - Matthew D. Lieberman (University of California, Los Angeles) 14. Commentary: Emotion in social neuroscience - Liz Phelps (New York University) IV. Navigating social life 15. The social brain in interactive games - James Rilling (Emory University) 16. Social pain: Experiential, neurocognitive, and genetic correlates - Naomi I. Eisenberger (University of California, Los Angeles) 17. Could an aging brain contribute to subjective well-being?: The value added by a social neuroscience perspective - John T. Cacioppo, Gary G. Berntson, Antoine Bechara, Daniel Tranel, Hanna Damasio & Louise C. Hawkley 18. Social neuroscience and the soul's last stand - Joshua D. Greene (Harvard University) 19. Commentary: Building a social brain General commentary: Hanging with social neuroscientists - Marcia Johnson (Yale University) Index

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Book SynopsisThe 8th edition of Wolff''s Headache and Other Head Pain remains the definitive reference text in the field. Understanding of headache and its management has improved significantly in the 21st century. A new international headache classification has been adopted, knowledge of headache pathophysiology and genetics has advanced, and epidemiologic studies have burgeoned. We have greater insights into the diagnosis and treatment of the secondary headaches. New treatments are available for primary headache disorders, including migraine, cluster, and chronic daily headache, with ongoing clinical trials producing new therapies. This edition incorporates all of these new developments, with all chapters updated and many new contributors added.Trade Review...excellent value for money...a must for all those professing an interest in headache and worth dipping into by all neurologists seeing headache patients (i.e. all neurologists!). * ACNR *Table of ContentsI: GENERAL CONSIDERATIONS: CLASSIFICATION, EPIDEMIOLOGY AND MECHANISM; II: DIAGNOSIS AND TREATMENT OF PRIMARY HEADACHE DISORDERS AND THEIR COMPLICATIONS; III: DIAGNOSIS AND TREATMENT OF SECONDARY HEADACHE DISORDERS; IV: SPECIAL TOPICS

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Book SynopsisElkhonon Goldberg's groundbreaking The Executive Brain was a classic of scientific writing, revealing how the frontal lobes command the most human parts of the mind. Now he offers a completely new book, providing fresh, iconoclastic ideas about the relationship between the brain and the mind. In The New Executive Brain, Goldberg paints a sweeping panorama of cutting-edge thinking in cognitive neuroscience and neuropsychology, one that ranges far beyond the frontal lobes. Drawing on the latest discoveries, and developing complex scientific ideas and relating them to real life through many fascinating case studies and anecdotes, the author explores how the brain engages in complex decision-making; how it deals with novelty and ambiguity; and how it addresses moral choices. At every step, Goldberg challenges entrenched assumptions. For example, we know that the left hemisphere of the brain is the seat of language--but Goldberg argues that language may not be the central adaptation of tTrade ReviewIt is only nowthat we are beginning to get the full measure of complexity [of the living body], to see how nature and culture interact, and how brain and mind produce each other. There are a handful, a small handful, of remarkable books which address these central problems with great forcethose of Gerald Edelman and Antonio Damasio at once come to mindand to this select number, Elkhonon Goldbergs book, The Executive Brain, should surely be added. * Oliver Sacks, The New York Review of Books *Anyone who is interested in the workings of the brain, sciences last frontier, will enjoy reading The Executive Brain The authors use of personal narrative and compelling metaphors help to make even the most technical information accessible to the general audience. * Science Editor *Goldberg is a good example of someone who seems to have always thought out of the box in both his personal and professional life. He has thus written a fine accessible book on executive brain functions One does not have to completely agree with a position to be stimulated by it, and Goldbergs book is certainly stimulating. * Contemporary Psychology: APA Review of Books *An intriguing exploration of the most challenging topic in cognitive neuroscience, the executive function of the prefrontal cortex. * American Scientist *Table of ContentsTHE MANY FACES OF LEADERSHIP; THE EXECUTIVE LOBE; THE MICROSCOPIC VIEW; THE MACROSCOPIC VIEW; THE COMMAND POST AND ITS CONNECTIONS; SOUNDS AND PLAYERS; NOAH'S PREDICAMENT AND THE LANDSCAPES OF THE BRAIN; NEUROPAGANISM: MODULE MADNESS; COGNITIVE GRADIENTS AND COGNITIVE HIERARCHIES; A THING IS A THING; A WORD TO A THING; AUTONOMY AND CONTROL IN THE BRAIN; AGNOSIAS AND HEMISPHERES; EXECUTIVE DEFICIT AND HEMISPHERES; NOVELTY AND THE FRONTAL LOBES; WORKING MEMORY-OR WORKING WITH MEMORY?; FREEDOM OF CHOICE, AMBIGUITY, AND THE FRONTAL LOBES; NEUROEVERYTHING; THE NEUROPSYCHOLOGY OF INDIVIDUAL DIFFERENCES; MALE AND FEMALE COGNITIVE STYLES; FRONTAL LOBES, HEMISPHERES, AND COGNITIVE STYLES; COGNITIVE STYLES AND BRAIN WRITING; REBELS IN SMALL PROPORTION: HANDEDNESS AND NOVELTY SEEKING; EXECUTIVE TALENTS: THE S FACTOR AND THE THEORY OF MIND; THE FRAGILE FRONTAL LOBES; FRONTAL LOBE SYNDROMES; DRIVE AND NEWTONIAN BODIES: A DORSOLATERAL CASE STUDY; PLANS AND THE "MEMORIES OF THE FUTURE"; RIGIDITY OF MIND; MIND BLINDSPOT: ANOSOGNOSIA; ORBITOFRONTAL "PSEUDOPSYCHOPATHIC" SYNDROME AND THE LOSS OF SELF-CONTROL; SOCIAL MATURITY AND THE FRONTAL LOBES; BIOLOGICAL MATURATION AND SOCIAL MATURITY: A HISTORICAL PUZZLE; FRONTAL LOBE DAMAGE AND CRIMINAL BEHAVIOR; THE HAPLESS ROBBER; FRONTAL LOBE DAMAGE AND THE PUBLIC BLINDSPOT; THE FALLEN HORSEMAN: A CASE STUDY; SCHIZOPHRENIA: A CONNECTION THAT WAS NEVER MADE; HEAD TRAUMA: A BROKEN CONNECTION; ATTENTION DEFICIT/HYPERACTIVITY DISORDER: A FRAGILE CONNECTION; ADHD CONQUERED: HOW TOBY FROM DOWN UNDER RECLAIMED HIMSELF; JERKY TIES AND TICKY JOKES; THE CORTEX AND THE STRIATUM; "COGNOTROPIC" DRUGS; JOGGING THE BRAIN; HISTORY OF COGNITIVE REHABILITATION; BRAIN PLASTICITY AND COGNITIVE EXERCISE; COGNITIVE FITNESS: BEGINNING OF A TREND; BEGINNINGS OF A PROGRAM; AUTONOMY AND CONTROL IN THE BRAIN; AUTONOMY AND CONTROL IN SOCIETY; AUTONOMY AND CONTROL IN THE DIGITAL WORLD

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Book SynopsisEpilepsy in our Words features 68 personal accounts of seizure activity from people with epilepsy that illustrate the wide range of experiences associated with seizures and living with epilepsy. Many have had epilepsy for years, and their accounts are heartfelt and realistic. An introductory section explains epilepsy and different seizure types from a medical perspective. An index helps readers focus on particular symptoms and other specific aspects of seizures, such as seizure warnings and triggers.ABOUT THE SERIES: With the Brainstorms series, one of the world''s leading authorities on epilepsy, Dr Steven C. Schachter, has gathered together the personal testimonies of patients, family members, and caregivers to create a poignant and gripping series of books on this misunderstood and often devastating disorder.Table of ContentsForeword ; Foreword ; Foreword ; Preface ; Acknowledgements ; Overview of Epilepsy and Seizures ; Seizure Descriptions ; Living with Epilepsy ; Index

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Book SynopsisThis book reveals the wide range of emotions, challenges and triumphs experienced by those who work with epilepsy patients and their families. The book also records the profound, uplifting and often heartbreaking experiences of practitioners with seizures who have come to understand, firsthand, the perspective of patients with epilepsy.ABOUT THE SERIES: With the Brainstorms series, one of the world''s leading authorities on epilepsy, Dr Steven C. Schachter, has gathered together the personal testimonies of patients, family members, and caregivers to create a poignant and gripping series of books on this misunderstood and often devastating disorder.Table of ContentsForeword ; Foreword ; Preface ; Tribute to Kiffin Penry, MD ; Contributing Authors ; Descriptions by Providers ; Providers with Epilepsy ; Appendix: Story Authors ; Index

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Book SynopsisIf you suffer from Tourette Syndrome (TS), or any other chronic motor or vocal tic disorder, you know how difficult it can be to manage your symptoms. You may be taking medication or working with a medical doctor to control your tics. If you are seeking an alternative or adjunctive treatment, you may wish to try the scientifically proven behavior therapy program described in this workbook.

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