Medicine / Healthcare: general issues / topics Books
John Wiley & Sons Inc Health Program Management
Book SynopsisLearn how to effectively plan, implement, and evaluate health programs Health Program Management: From Development Through Evaluation, Second Edition is a practical and useful introduction to the management of health programs. While providing an overview of the current best practices in management, the textbook goes beyond simple management techniques, teaching students how to develop, lead, and evaluate their programs to ensure quality outcomes. The focus is on the three core management concepts of strategy, design, and leadership, but time is also devoted to describing facilitative management activities integral to successful programs. Students will learn techniques for communication, decision-making, quality assurance, marketing, and program evaluation within the structure of the book''s program management model. Logically organized with a separate chapter for each activity, this resource provides a thorough, systematic overview of the effective development, implemTable of ContentsList of Figures, Tables, and Exhibits xi Preface xv Acknowledgments xxi The Author xxiii Chapter 1 The Work of Managers in Health Programs 1 Key Definitions 2 The Work of Program Managers in Terms of Core and Facilitative Activities 7 Core Activities in Program Management Work 7 Facilitative Activities in Program Management Work 12 Roles Played by Program Managers: The Mintzberg Model 17 Competencies That Underpin Program Management Work 20 Managing Health Programs Ethically 24 Managers and the Success of Programs 29 Appendix A: Example of a Health Program: The Global Health Program of The Bill and Melinda Gates Foundation 35 Appendix B: Example of a Health Project: The Mass General Care Management Project 37 Chapter 2 Developing/Strategizing the Future 39 Developing the Underlying Theory of a Program 40 Using Program Theory and Logic Models in Establishing and Maintaining Effective Stakeholder Relationships 42 Developing/Strategizing Activity 44 Situational Analysis: Determining a Program’s Current Situation 45 Reconsidering and Revising a Program’s Current Situation 54 Assessing and Controlling Performance to Achieve Desired Results 59 The Link between Developing/Strategizing and the Performance of Programs 66 Writing a Business Plan 67 Planning for Interventions Undertaken by Programs 69 Chapter 3 Designing For Effectiveness 81 Creating Organization Designs 82 Key Concepts in Formal Organization Design 83 Application of the Key Organization Design Concepts 99 Informal Aspects of Organization Designs 102 Designing Program Logic Models 107 The Staffing Process in Health Programs 109 Chapter 4 Leading to Accomplish Desired Results 119 Leading Defined 120 Influence and Leading; Interpersonal Power and Influence 121 Motivation as a Basis for Leading Effectively 123 The Ongoing Search to Understand Effective Leading 139 Toward an Integrative Approach to Effective Leading in Health Programs 151 Chapter 5 Making Good Management Decisions 161 Decision Making Defined 162 Involving Other Program Participants in Decision Making 163 Key Characteristics of Management Decisions and Decision Making in Programs 166 The Decision-Making Process 168 Chapter 6 Communicating for Understanding 203 Communicating: Key to Effective Stakeholder Relations 204 A Model of the Communication Process 208 Barriers to Communicating Effectively 211 Communicating within Programs 217 Communicating with External Stakeholders 222 Communicating When Something Goes Wrong 226 Chapter 7 Managing Quality—Totally 237 Quality Defined 239 Measuring Quality 241 Managing Quality 242 A Total Quality Approach to Managing Quality 243 Patient/Customer Focus 244 Continuous Improvement 245 Teamwork 254 Chapter 8 Commercial and Social Marketing 269 Commercial Marketing 270 Social Marketing 270 Commercial Marketing in Health Programs 271 The Five Ps of Commercial Marketing 276 Social Marketing in Health Programs 288 Conducting Social Marketing Initiatives in Health Programs 289 Ensuring the Success of Social Marketing Initiatives 294 Ethics Considerations in Commercial and Social Marketing Strategies 295 Appendix C: A Step-by-Step Social Marketing Process 303 Chapter 9 Evaluating 309 Program Evaluation Defined 310 What Do Program Managers Evaluate? 311 Program Theory and Logic Models 312 Types of Program Evaluations 316 The CDC Framework for Conducting Program Evaluations 318 Standards in the CDC Evaluation Framework 319 Steps in the CDC Evaluation Framework 320 Index 341
£999.99
John Wiley and Sons Ltd Alcohol Abuse and Liver Disease
Book SynopsisAlcoholics with liver disease represent some of the most challenging patients to treat. With a joint hepatology/psychiatry focus, leading experts offer practical, clinical guidance on how best to deliver first-class management and outstanding patient care. .Table of ContentsList of Contributors vii Preface xi 1 Epidemiology of alcohol use 1Ian Gilmore and William Gilmore 2 Epidemiology of alcohol]related liver disease 11Ed Britton and Martin Lombard 3 Alcoholism: diagnosis and natural history in the context of medical disease 23Thomas P. Beresford Narin Wongngamnit and Benjamin A. Temple 4 Alcohol and other substance misuse 35John B. Saunders 5 Risk factors for alcohol]related liver disease 47Stuart Kendrick and Chris Day 6 Mechanisms of alcohol toxicity 55Guruprasad P. Aithal and Jane I. Grove 7 Extrahepatic manifestations of alcohol excess 65Karl]Heinz Schulz Sandra van Eckert and Jens Reimer 8 Patterns of alcohol]associated liver damage 79Peter Hayes and Michael Williams 9 Cofactors and alcohol]related liver disease 87John G. O’Grady 10 Impact of alcohol and liver disease on prescribing 91Richard Parker and Amanda Smith 11 Psychiatric examination of liver transplant patients with alcohol use disorders 99Robert M. Weinrieb and Omair Abbasi 12 Abnormal liver tests in the context of alcohol excess 109James Ferguson 13 Biochemical determination of alcohol consumption 113Friedrich Martin Wurst Natasha Thon Wolfgang Weinmann Michel Yegles Jessica Wong and Ulrich W. Preuss 14 The role of histology 123Desley A.H. Neil 15 General assessment and management 135Patrizia Burra and Giacomo Germani 16 Brief alcohol interventions 147Stephanie Scott and Eileen Kaner 17 Alcohol withdrawal syndrome: diagnosis and treatment 155Julie Taub and Thomas P. Beresford 18 Psychosocial treatments of alcohol use disorders 165Terry D. Schneekloth 19 Pharmacologic interventions 175Renata Yang and Marian Fireman 20 Treatment of extrahepatic manifestations of alcohol abuse 187Joaquim Fernandez]Sola 21 Treatment of liver disease 197James Neuberger 22 Treatment of alcoholic hepatitis 203Mark Thursz and Stephen Atkinson 23 Liver transplantation in people with alcohol]related liver disease 215Santiago Tome and Michael R. Lucey 24 Future directions: the need for early identification and intervention for patients with excessive alcohol use 223Andrea DiMartini Shari Rogal and Stephen Potts Index 235
£82.76
John Wiley and Sons Ltd Pancreatitis
Book SynopsisPancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.Trade Review"Overall, this is an excellent book on all aspects of acute and chronic pancreatitis. It is concise yet comprehensive, written by well-known and well-published, credible authorities. It will be useful not just to the intended audience of gastroenterologists and GI surgeons, but also to all physicians involved in the care of patients with pancreatitis. Most books try to cover all aspects of this complex condition in a summary fashion, which is not possible. This book fills in the gaps by providing a focused, comprehensive review including latest evidence and guidelines. 5 Stars!" (Doody Enterprises July 2017)"This is a definitive and authoritative work that is quite manageable to read, understand and process.Because of that, a reader will return to it often, extending its benefits. Pancreatitis is challengingenough without having what this book provides. This excellent contribution has indeed refreshed andadvanced my own knowledge-base by performing this review. Even the most seasoned practitioner cangarner value in its pages, and again, return to it often" Charles M. Vollmer, Jr, MD, Professor of Surgery, University of Pennsylvania Perelman School of Medicine on behalf of HPB, Summer 2017Table of ContentsList of contributors, vii 1 Epidemiology and genetics of chronic pancreatitis, 1 2A Pathobiology of the acinar cell in acute pancreatitis, 10 2B Locoregional pathophysiology in acute pancreatitis: pancreas and intestine, 19 2C Pathophysiology of systemic inflammatory response syndrome and multiorgan dysfunction syndrome in acute pancreatitis, 29 3 Diagnosis, prediction, and classification, 38 4 Medical treatment, 47 5 Nutritional treatment in acute pancreatitis, 55 6 Gallstone pancreatitis: diagnosis and treatment, 64 7 Treatment of local complications, 75 8 Treatment of systemic complications and organ failure, 85 9 Specific treatment for acute pancreatitis, 91 10 Sequelae of acute pancreatitis, 101 11 History of chronic pancreatitis, 113 12A Epidemiology and pathophysiology: epidemiology and risk factors, 118 12B Epidemiology and pathophysiology: genetic insights into pathogenesis, 126 12C Pancreatic stellate cells: what do they tell us about chronic pancreatitis?, 143 12D Autoimmune pancreatitis: an update, 152 12E Etiology and pathophysiology: tropical pancreatitis, 161 12F Mechanisms and pathways of pain in chronic pancreatitis, 169 13A Imaging of chronic pancreatitis, 179 13B Endoscopic ultrasonography in chronic pancreatitis, 188 14A Pancreatic enzyme replacement therapy (PERT), 195 14B Nutritional treatment: antioxidant treatment, 205 14C Pancreatogenic diabetes: etiology, implications, and management, 211 14D Nutrition without a pancreas: how does the gut do it?, 225 15A Endoscopic management of chronic pancreatitis, 233 15B Shocking and fragmenting pancreatic ductal stones, 245 15C Endoscopic management: celiac plexus blockade, 249 16A A brief history of modern surgery for chronic pancreatitis, 256 16B Surgery for chronic pancreatitis: indications and timing of surgery, 261 16C Chronic pancreatitis: surgical strategy in complicated diseases, 265 16D Surgery for chronic pancreatitis: pancreatic duct drainage procedures, 273 16E Surgical management: resection and drainage procedures, 279 16F The role of pancreatoduodenectomy in the management of chronic pancreatitis, 286 17A Total pancreatectomy and islet cell autotransplantation: patient selection, 295 17B Total pancreatectomy and islet cell autotransplantation: the science of islet cell preservation, from pancreas to liver, 299 17C Total pancreatectomy and islet cell autotransplantation: long-term assessment of graft function, 308 Index, 321
£999.99
John Wiley and Sons Ltd Current Therapy in Endodontics
Book SynopsisDentistry has been undergoing enormous changes, and the field of endodontics has certainly been at the forefront. Recent advances in technology, materials, and equipment have changed the way endodontics is practiced today, thereby facilitating treatments with greater efficiency, precision, and success, ultimately leading to better outcomes.Table of ContentsList of figures, ix List of tables, xxiii Contributors, xxv Foreword, xxvii Preface, xxix Acknowledgements, xxxi 1 Diagnosis, 1Reza Farshey 2 Imaging technologies, 15Reza Farshey 3 Rotary instruments, 27Priyanka Jain 4 Determination of working length, 87Priyanka Jain 5 Root canal filling, 111Priyanka Jain, Mahantesh Yeli and Kakul Dhingra 6 Treatment planning of pulpless teeth, 141Faysal Succaria and Sami M. Chogle 7 Dental traumatic injuries, 153Zuhair Al Khatib and Edward Besner 8 Visualization in endodontics, 192Carla Cabral dos Santos Accioly Lins, Diógenes Ferreira Alves, and Angelo Barbosa de Resende9 Endodontic microsurgery, 202James D. Johnson, Kathleen McNally, Scott B. McClanahan, and Stephen P. Niemczyk 10 Lasers, 258Mohammed Alshahrani, Brian Beebe, and Sami M. Chogle 11 Dental pulp regeneration, 271Sahng G. Kim 12 Teledentistry, 281Mansi Jain Quiz answers, 289 Index, 291
£94.95
John Wiley and Sons Ltd Manual of STEMI Interventions
Book SynopsisBenefit from this concise yet comprehensive manual, designed to improve the practice and process of STEMI interventions Understand the varied pharmacological options available in managing STEMI patients, including newer anti-coagulants Improve your STEMI procedure technique through expert guidance, including stent choice, and other techniques such as trans radial proceduresProvides an overview of STEMI networks internationally and how to set up a STEMI programReviews future perspectives for STEMI and the role of telemedicine for STEMI proceduresTable of ContentsList of Contributors ix Preface xiii Part I Guidelines, Thrombolytic Therapy, Pharmacology 1 1 Compendium of STEMI Clinical Trials 3Juanita Gonzalez Arango MD, Miguel Vega Arango MD, Estefania Calle Botero MD, Isaac Yepes Moreno MD, Maria Botero Urrea MD, Alicia Henao Velasquez MD, Daniel Rodriguez MD, Daniela Parra Dunoyer MD, Maria Teresa Bedoya Reina MD, Sameer Mehta MD 2 European Society of Cardiology and American College of Cardiology STEMI Guidelines 35Estefania Oliveros MD, Sameer Mehta MD FACC, Alexandra Ferré MD, Tracy Zhang BS, Michael Schweitzer MD, Miguel Vega Arango MD, Juanita Gonzalez Arango MD, Maria Botero Urrea MD, Maria Teresa Bedoya Reina MD, Isaac Yepes MD 3 The Role of Thrombolytic Therapy in the Era of STEMI Interventions 55Nestor Mercado MD, Theodore L. Schreiber MD, Cindy L. Grines MD 4 Anticoagulants in STEMI Interventions 65Vincenzo Vizzi MD, Thomas W. Johnson BSc MBBS MD FRCP, Andreas Baumbach MD 5 New Oral and Intravenous Adenosine Diphosphate Blockers in STEMI Intervention 75James J. Ferguson III MD Part II The STEMI Procedure 105 6 The Role of Acute Circulatory Support in STEMI 107Yousef Bader MD, Navin K. Kapur MD 7 Thrombus Management for STEMI Interventions 119Sameer Mehta MD, Olga Reynbakh MD, Daniel Rodriguez MD, Tracy Zhang BS, Michael Schweitzer MD, Maria Teresa Bedoya Reina MD, Miguel Vega Arango MD, Juanita Gonzalez Arango MD, Maria Botero Urrea MD 8 Transradial Techniques to Improve STEMI Outcomes 145Tejas Patel MD DM FACC FESC FSCAI, Sanjay Shah MD DM, Samir Pancholy MD FACC FSCAI 9 Management of Cardiogenic Shock 159Holger Thiele MD, Suzanne de Waha MD 10 Present Role of Thrombectomy in STEMI Interventions 171Francesco Giannini MD, Azeem Latib MD, Antonio Colombo MD 11 Choice of Stent in STEMI Interventions 187Roopa Salwan MD 12 Illustrated STEMI Procedures I – Basic STEMI Skills 207Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD 13 Illustrated STEMI Procedures II – Basic STEMI Skills 223Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD 14 Illustrated STEMI Procedures III – Basic STEMI Skills 239Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD 15 Remote Ischemic Conditioning for Acute Myocardial Infarction 255Hans Erik Bøtker MD PhD FACC FESC, Gerd Heusch MD FACC FESC FRCP Part III The STEMI Process 273 16 Reducing Door‐to‐Balloon Times 275Michel Le May MD, Joshua PY Loh MD 17 Pre‐hospital Triage and Management 285Ivan Rokos MD 18 Creating Networks for Optimal STEMI Management 299David C. Lange MD, David M. Larson MD, David Hildebrandt RN, Timothy D. Henry MD 19 Pharmacoinvasive Management of STEMI 315Neeraj Bhalla MD Part IV Global STEMI Initiatives 325 20 Stent for Life: The European Perspective on STEMI Interventions 327Sasko Kedev MD PhD FESC FACC 21 Urban Combined Pharmacoinvasive Management of STEMI Patients as Antidote to Traffic in Large Metropolitan Cities 333David G. Iosseliani MD FACC FESC 22 Lessons from the Puerto Rico Infarction National Collaborative Experience Initiative 343Orlando Rodríguez‐Vilá MD MMS FACC FSCAI, Jose Escabi‐Mendoza MD FACC, Fernando Lapetina‐Irizarry MD FACC, Miguel A. Campos‐Esteve MD FACC 23 The STEMI Care Program in China 357Yan Zhang MD, Yong Huo MD 24 STEMI INDIA 363Thomas Alexander MD, Ajit S Mullasari MD 25 The Role of Telemedicine in STEMI Interventions 371Roberto Vieira Botelho MD PhD, Sameer Mehta MD FACC MBA, Julius Cezar Q. Ladeira DDS MSc, Francisco Fernandéz MBA, Márcio Sanches MD, Denis Fabiano de Souza RN, Wladimir Fernandes de Rezende MBA, Carlos Otávio Lara Pinheiro BSc 26 Innovative Telemedicine STEMI Protocols 379Sameer Mehta MD FACC MBA, Roberto Vieira Botelho MD PhD, Freddy Bojanini MD, Juan Corral MD, Marco Perin MD, María Teresa Bedoya Reina MD, Juliana Giraldo MD, Laura Álvarez MD, Cindy Manotas MD, Sebastián Moreno MD, Sergio Reyes MD, María Botero Urrea MD Part V Future Perspectives 395 27 STEMI Interventions, Beyond the Culprit Lesion 397Neil Ruparelia PhD MRCP, Antonio Colombo MD, Azeem Latib MD 28 Promising Technologies for STEMI Interventions 409Joshua PY Loh MD, HC Tan Index 421
£999.99
John Wiley and Sons Ltd Atlas of the Diabetic Foot
Book SynopsisThe revised and updated third edition of the essential guide to the diagnosis and treatment of the diabetic foot The revised third edition of the Atlas of the Diabetic Foot is an updated guide to the information needed for the prevention and treatment of diabetic foot problems with the aim of reducing amputations. In addition to offering the theoretical knowledge, the book is filled with more than 500 color photos from real-life cases. The cases explore a wide-variety of foot issues and the text includes information about differential diagnosis and treatment. The authorsnoted experts in the fielddescribe the epidemiology, pathophysiology and classification of diabetic foot ulcers. In addition, the book highlights the diagnosis of the main risk factors for the diabetic foot, namely diabetic neuropathy, peripheral arterial disease and the anatomic deformities of the lower extremities. The updated third edition, include 5 videos that clearly demonstrate the Table of ContentsPreface to the Third Edition vii Preface to the Second Edition ix Preface to the First Edition xi Acknowledgements xiii About the Companion Website xv 1 Introduction 1 2 Diabetic Neuropathy 11 3 Anatomic Risk Factors for Diabetic Foot Ulceration 23 4 Other Foot-Related Risk Factors 49 5 Skin and Systemic Diseases with Manifestations in the Feet 63 6 Neuropathic Ulcers 75 7 Peripheral Vascular Disease 91 8 Ischemic and Neuro-Ischemic Ulcers and Gangrene 107 9 Heel Ulcers 135 10 Charcot Foot 147 11 Infections 169 12 Methods of Prevention 197 13 Methods of Ulcer Healing 205 14 Amputations 229 Appendix 237 Index 239
£123.95
John Wiley & Sons Inc Applied Mathematics for the Analysis of
Book SynopsisFeatures a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB toolbox for the collection, visualization, and evaluation of experimental and real-life data Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and governmentsponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from realworld data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods Table of ContentsPreface xi Acknowledgements xiii About the Companion Website xv Introduction xvii 1 Data 1 1.1 Data Visualization 1 1.2 Data Transformations 3 1.3 Data Filtering 7 1.4 Data Clustering 17 1.5 Data Quality and Data Cleaning 25 References 28 2 Some Examples 29 2.1 Glucose–Insulin Interaction 30 2.2 Transition from HIV to AIDS 33 2.3 Real-Time Polymerase Chain Reaction 37 References 45 Further Reading 45 3 SEIR Models 47 3.1 Practical Applications of SEIR Models 50 References 88 Further Reading 90 4 Statistical Pattern Recognition and Classification 93 4.1 Measurements and Data Classes 94 4.2 Data Preparation Normalization and Weighting Matrix 98 4.3 Principal Components 104 4.4 Discriminant Analysis 107 4.5 Regularized Discriminant Analysis and Classification 112 4.6 Minimum Bayes Score Maximum Likelihood and Minimum Bayes Risk 116 4.7 The Confusion Matrix Receiver–Operator Characteristic Curves and Assessment Metrics 122 4.8 An Example 127 4.9 Nonlinear Methods 131 References 139 Further Reading 140 5 Biostatistics and Hypothesis Testing 141 5.1 Hypothesis Testing Framework 142 5.2 Test of Means 157 5.3 Tests of Proportions 179 5.4 Tests of Variances 212 5.5 Other Hypothesis Tests 232 References 268 Further Reading 270 6 Clustered Data and Analysis of Variance 271 6.1 Clustered Matched-Pair Data and Non-Inferiority 273 6.2 Clustered Data Assessment Metrics and Diagnostic Likelihood Ratios 278 6.3 Relative Diagnostic Likelihood Ratios 286 6.4 Analysis of Variance for Clustered Data 291 6.5 Examples for Anova 300 6.6 Bootstrapping and Confidence Intervals 314 References 316 Further Reading 316 Appendix: Mathematical Matters 317 Glossary of MATLAB Functions 335 Index 407
£102.55
John Wiley and Sons Ltd Journal of Prosthodontics on Complex Restorations
Book SynopsisJournal of Prosthodontics on Complex Restorations compiles 34 of the journal s best articles discussing complex restorative dental challenges, collecting notable works on the subject.Table of ContentsPreface Acknowledgments PART I- Management of Maxillofacial Defects Using CAD/CAM Technology 1. Comparative Accuracy of Facial Models Fabricated Using Traditional and 3D Imaging Techniques2. Innovative Approach for Interim Facial Prosthesis Using Digital Technology3. Updates on the Construction of an Eyeglass-Supported Nasal Prosthesis Using Computer-Aided Design and Rapid Prototyping Technology4. Ocular Defect Rehabilitation Using Photography and Digital Imaging: A Clinical Report PART II- Management of Tooth Wear5. Full-Mouth Rehabilitation of a Patient with Gastroesophageal Reflux Disease: A Clinical Report6. Rehabilitation of a Bulimic Patient Using Endosteal Implants7. Fixed Prosthodontic Rehabilitation in a Wear Patient with Fabry’s Disease8. Analyzing the Etiology of an Extremely Worn Dentition9. Full-Mouth Rehabilitation of a Patient with Severely Worn Dentition and Uneven Occlusal Plane: A Clinical Report10. Implant-Supported Prosthetic Rehabilitation of a Patient with Localized Severe Attrition: A Clinical Report 11. Restoration of the Occlusal Vertical Dimension with an Overlay Removable Partial Denture: A Clinical Report PART III- Management of Congenital Disorders 12. Full Mouth Rehabilitation of a Hypohidrotic Ectodermal Dysplasia Patient with Dental Implants: A Clinical Report13. Prosthetic Rehabilitation with Collapsible Hybrid Acrylic Resin and Permanent Silicone Soft Liner Complete Denture of a Patient with Scleroderma-Induced Microstomia14. Nasoalveolar Molding and Long-Term Postsurgical Esthetics for Unilateral Cleft Lip/Palate: 5-Year Follow-Up 15. Interdisciplinary Care for a Patient with Amelogenesis Imperfecta: A Clinical Report 16. Maxillary Rehabilitation Using a Removable Partial Denture with Attachments in a Cleft Lip and Palate Patient: A Clinical Report17. Treatment of a Patient with Cleidocranial Dysplasia Using a Single-Stage Implant Protocol 18. Full-Mouth Rehabilitation of an Edentulous Patient with Papillon-Lefèvre Syndrome Using Dental Implants: A Clinical Report PART IV- Management of Orthodontic/Prosthodontic Patients19. Aspects of Orthodontic-Prosthetic Rehabilitation of Dentofacial Anomalies 20. Orthodontic Treatment and Implant-Prosthetic Rehabilitation of a Partially Edentulous Patient21. Prosthetic Rehabilitation of a Cleidocranial Dysplasia Patient with Vertical Maxillofacial Deficiency: A Clinical Report22. Occlusal Rehabilitation of Pseudo-Class III Patient PART V- Management of Patients with Surgical and Prosthodontic Challenges23. Alveolar Distraction Osteogenesis of the Severely Atrophic Anterior Maxilla: Surgical and Prosthetic Challenges24. Rehabilitation of a Completely Edentulous Patient with Nonreducible Bilateral Anterior Dislocation of the Temporomandibular Joint: A Prosthodontic Challenge—Clinical Report25. Prosthodontic Rehabilitation of a Shotgun Injury: A Patient Report 26. Surgical and Prosthodontic Treatment of a Patient with Significant Trauma to the Middle and Lower Face Secondary to a Gunshot Wound: A Clinical Report 27. Treatment of Hemi-Mandibulectomy Defect with Implant-Supported Telescopic Removable Prosthesis. A Clinical Report PART VI- Management of Completely Edentulous Patients Using New Ceramic Material 28. The Use of Custom-Milled Zirconia Teeth to Address Tooth Abrasion in Complete Dentures: A Clinical Report29. Retrievable Metal Ceramic Implant-Supported Fixed Prostheses with Milled Titanium Frameworks and All-Ceramic Crowns: Retrospective Clinical Study with up to 10 Years of Follow-Up 30. Implant-Supported Fixed Dental Prostheses with CAD/CAM-Fabricated Porcelain Crown and Zirconia-Based Framework31. Full Zirconia Fixed Detachable Implant-Retained Restorations Manufactured from Monolithic Zirconia: Clinical Report after Two Years in Service32. Maxillary Full-Arch Immediately Loaded Implant-Supported Fixed Prosthesis Designed and Produced by Photogrammetry and Digital Printing: A Clinical Report33. Full-Arch, Implant-Supported Monolithic Zirconia Rehabilitations: Pilot Clinical Evaluation of Wear Against Natural or Composite Teeth34. Double Full-Arch Versus Single Full-Arch, Four Implant-Supported Rehabilitations: A Retrospective, 5-Year Cohort StudyIndex
£999.99
John Wiley and Sons Ltd Pediatric Cardiac Surgery
Book SynopsisTable of Contents1. Development of the Heart and Great Vessels Ram Kumar Subramanyan, Robert H. Anderson, Peter J. Gruber 2. Genetics of Congenital Heart Disease Peter J. Gruber 3. Fetal Cardiac Physiology and Fetal Cardiac Intervention Timothy S. Lancaster, Jacob R. Miller, and Pirooz Eghtesady 4. Preoperative Diagnostic Evaluation Barbara J. Deal, Amanda Hauck, Sabrina Tsao, Angira Patel, Simon Lee, and Doff B. McElhinney 5. Hybrid Procedures for Congenital Heart Disease Hakan Akintuerk, Dietmar Schranz, Norbert Voelkel 6. Anesthesia for the Patient with Congenital Heart Disease H. Jay Przybylo 7. Perioperative Care Mjaye L. Mazwi, Carl L. Backer, John M. Costello, and Constantine Mavroudis 8. Palliative Operations Carl L. Backer and Constantine Mavroudis 9. Management of Pediatric Cardiopulmonary Bypass Nicholas D. Andersen, James M. Meza, and Joseph W. Turek 10. Pediatric Myocardial Protection Sachin Talwar and Shiv Kumar Choudhary 11. Patent Arterial Duct Elizabeth H. Stephens, Paul Tannous, Carl L. Backer, and Constantine Mavroudis 12. Vascular Rings and Pulmonary Artery Sling Carl L. Backer, Cynthia K. Rigsby, and Constantine Mavroudis 13. Coarctation of the Aorta Carl L. Backer, Joseph A. Dearani, and Constantine Mavroudis 14. Interrupted Aortic Arch Dilip S. Nath and Richard A. Jonas 15. Atrial Septal Defect, Partial Anomalous Pulmonary Venous Connection, and Scimitar Syndrome Carl L. Backer, Paul Tannous, and Constantine Mavroudis 16. Ventricular Septal Defect Constantine Mavroudis, Carl L. Backer, and Robert H. Anderson 17. Atrioventricular Septal Defects Carl L. Backer and Constantine Mavroudis 18. Common Arterial Trunk Constantine Mavroudis and Carl L. Backer 19. Aortopulmonary Window and Aortic Origin of a Pulmonary Artery Stephanie Fuller and Robert H. Anderson 20. Isolated Right Ventricular Outflow Tract Obstruction Ali Dodge-Khatami and Christopher E. Greenleaf 21. Tetralogy of Fallot Ali Dodge-Khatami, Peter Chen, and Constantine Mavroudis 22. Tetralogy of Fallot with Pulmonary Atresia and Major Aortopulmonary Collaterals Matthew Liava'a and Yves d'Udekem 23. Ventricular to Pulmonary Artery Conduits John W. Brown and Jeremy L. Herrmann 24. Double-Outlet Right Ventricle Constantine Mavroudis, Carl L. Backer, and Robert H. Anderson 25. Transposition of the Great Arteries Constantine Mavroudis and Carl L. Backer 26. Congenitally Corrected Transposition of the Great Arteries Tom R. Karl and Jeffery P. Jacobs 27. The Functionally Univentricular Heart Peter Sassalos, Ming-Sing Si, Jennifer C. Romano, Edward L. Bove, and Richard G. Ohye 28. Fontan Conversion Constantine Mavroudis, Barbara J. Deal, and Carl L. Backer 29. Ebstein Malformation Kimberly A. Holst and Joseph A. Dearani 30. Left Ventricular Outflow Tract Obstruction William M. DeCampli and Kamal K. Pourmoghadam 31. Hypertrophic Cardiomyopathy William M. DeCampli and Kamal K. Pourmoghadam 32. Hypoplastic Left Heart Syndrome Chunsoo Park and James S. Tweddell 33. Aorto-Left Ventricular Tunnel Jeremy L. Herrmann and Stephanie Fuller 34. Congenital Anomalies of the Mitral Valve Perry S. Choi and Sitaram M. Emani 35. Total Anomalous Pulmonary Venous Connection Rachel D. Vanderlaan and Christopher A. Caldarone 36. Cor Triatriatum, Pulmonary Vein Stenosis, and Atresia of the Common Pulmonary Vein Constantine D. Mavroudis, Robert H. Anderson, and Constantine Mavroudis 37. Anomalous Systemic Venous Connections Henry L. Walters, III and Ralph E. Delius 38. Connective Tissue Disorders Charles D. Fraser III, Trevor Ellison, Duke E. Cameron, Luca A. Vricella 39. Coronary Artery Anomalies Constantine Mavroudis, Ali Dodge-Khatami, and Carl L. Backer 40. Cardiac Tumors Rudiger Lange and Thomas Gunther 41. Diseases of the Pericardium Elizabeth H. Stephens and Victor O. Morell 42. Surgical and Transcatheter Management of Arrhythmias Barbara J. Deal, MD and Constantine Mavroudis, MD 43. Pediatric Heart Transplantation Charles B. Huddleston and Andrew C. Fiore 44. Lung and Heart-Lung Transplantation Charles B. Huddleston and Andrew C. Fiore 45. Endocarditis in Patients with Congenital Heart Disease Peter D. Wearden and Constantine Mavroudis 46. Pediatric Mechanical Circulatory Support Michelle Ploutz, Angela Lorts, and David L.S. Morales 47. Adult Congenital Heart Disease Maria Drakopoulou, Konstantinos Dimopoulos, Stamatia Prapa, Darryl F. Shore, Stella Brili, and Michael Gatzoulis 48. Bioethics in Congenital Heart Surgery Constantine Mavroudis, Constantine D. Mavroudis, Thomas Cook, Catherine L. Mavroudis, Allison Siegel, and Alex Golden 49. Education in Congenital Cardiac Surgery Constantine D. Mavroudis, Constantine Mavroudis, Carl L. Backer, and Richard H. Feins
£180.45
John Wiley & Sons Inc Extracellular Targeting of Cell Signaling in
Book SynopsisInternational experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell suTable of ContentsList of Contributors xiii Preface xvii 1 Discovery and Function of the HGF/MET and the MSP/RON Kinase Signaling Pathways in Cancer 1Silvia Benvenuti, Melissa Milan and Paolo M. Comoglio 1.1 Introduction 1 1.2 MET Tyrosine Kinase Receptor and its Ligand HGF: Structure 1 1.2.1 The Invasive growth Program 2 1.2.2 MET Mediated Signaling 4 1.2.2.1 MET Down-regulation 7 1.2.3 Cross-talk between MET and Other Receptors 7 1.2.4 MET Activation in Human Cancers 9 1.2.4.1 MET, Hypoxia and Ionizing Radiations 10 1.2.4.2 MET Expression in Cancer Stem Cells: a Paradigm of Inherence 11 1.2.4.3 Oncogene Addiction and Oncogene Expedience 11 1.2.5 Targeting HGF/MET as a Therapeutic Approach in Human Cancer 12 1.2.5.1 HGF Antagonists 13 1.2.5.2 Tyrosine Kinase Inhibitors 15 1.2.5.3 Anti-MET Monoclonal Antibodies 17 1.2.5.4 Alternative MET Blocking Strategies 18 1.2.6 Primary and Secondary Resistance 18 1.2.6.1 MET Role in Resistance to Anticancer Agents 19 1.2.6.2 Mechanism of Resistance to MET Inhibitors 19 1.2.6.3 Combinatorial Therapeutic Strategies 20 1.3 RON Tyrosine Kinase Receptor and its Ligand MSP 21 1.3.1 Discovery and Structural Biology 21 1.3.2 RON Mediated Signaling 25 1.3.3 Cross-talk between RON and other Receptors 26 1.3.4 RON Activation in Human Cancers 26 1.4 Targeting MSP/RON as a Therapeutic Approach in Human Cancer 27 1.5 Concluding Remarks 28 2 The Role of HGF/MET and MSP/RON Signaling in Tumor Progression and Resistance to Anticancer Therapy 45Lidija Klampfer and Benjamin Yaw Owusu 2.1 Introduction 45 2.2 HGF/MET Signaling in Cancer 47 2.3 MSP/RON Signaling in Cancer 52 2.4 Cross-talk between MET and RON Signaling Pathways 53 2.5 HGF/MET and MSP/RON Signaling Elicit Resistance to Cancer Therapy 55 2.6 Conclusions and Perspectives 58 References 58 3 HGF Activator (HGFA) and its Inhibitors HAI-1 and HAI-2: Key Players in Tissue Repair and Cancer 69Hiroaki Kataoka and Takeshi Shimomura 3.1 Introduction 69 3.2 Discovery of HGFA 70 3.2.1 Tissue Injury-induced Activation of HGF 70 3.2.2 Identification of HGFA as a Serum Activator of pro-HGF 71 3.3 Synthesis of HGFA Zymogen in vivo 71 3.4 Molecular Structure of HGFA 72 3.4.1 The Gene Encoding pro-HGFA: HGFAC 72 3.4.2 ProHGFA Protein and its Activation 72 3.4.3 Structure Biology of HGFA 74 3.5 Substrates of HGFA in vivo 75 3.6 Regulation of HGFA Activity by Endogenous Inhibitors 76 3.6.1 HGF Activator Inhibitor-1 (HAI-1): a Cell Surface Regulator of HGFA Activity 76 3.6.2 HGF Activator Inhibitor-2 (HAI-2) 78 3.6.3 Protein C Inhibitor (PCI; SERPINA5) 78 3.7 Proposed Biological Functions of HGFA in vivo 78 3.8 Roles of HGFA in Cancer 80 3.8.1 Enhanced Activation of pro-HGF and pro-MSP in Cancer Tissues 80 3.8.2 Possible Roles of HGFA in Cancer Progression 80 3.9 Conclusions and Future Perspectives of HGFA Research in Cancer 82 References 83 4 Physiological Functions and Role of Matriptase in Cancer 91Fausto A. Varela, Thomas E. Hyland and Karin List 4.1 Introduction 91 4.2 Discovery of Matriptase 91 4.3 Biochemical and Functional Characteristics of Matriptase – Inhibitors, Substrates and Structure 92 4.3.1 Endogenous Polypeptide Matriptase Inhibitors 92 4.3.2 Matriptase Substrates 94 4.3.3 Matriptase Structure 95 4.4 Physiological and Pathophysiological Functions of Matriptase 96 4.4.1 Matriptase in Epidermal Development and Homeostasis 96 4.4.2 Matriptase in the Gastrointestinal Tract 97 4.4.3 Matriptase in Thymocytes and Salivary Glands 98 4.4.4 Matriptase in Placental/Embryonic Development 98 4.4.5 Matriptase in Neural Tube Closure 99 4.4.6 Pathways requiring Matriptase 99 4.4.7 Matriptase in Viral Infection 101 4.5 Role of Matriptase in Cancer 101 4.5.1 Studying Matriptase in Cultured Cancer Cells and Tumor Grafting Models 108 4.5.2 In vivo Cancer Studies using Genetic Models 111 4.5.2.1 Squamous Cell Carcinoma 111 4.5.2.2 Colitis-associated Colon Carcinogenesis 112 4.5.2.3 Breast Cancer 112 4.6 Conclusions 114 References 114 5 The Cell-Surface, Transmembrane Serine Protease Hepsin: Discovery, Function and Role in Cancer 125Denis Belitškin, Shishir Mani Pant, Topi Tervonen and Juha Klefström 5.1 Biology of Hepsin 125 5.1.1 Discovery of Hepsin 125 5.1.1.1 Cloning of Hepsin, HPN Gene 125 5.1.1.2 Assigning Hepsin to Type II Transmembrane Serine Protease Family 126 5.1.2 Hepsin Gene and Protein 126 5.1.2.1 Expression, Regulation and Structure 126 5.1.2.2 Hepsin Activation and Activity 130 5.1.3 Physiological Functions of Hepsin 131 5.1.3.1 Growth Factor Activation 131 5.1.3.2 Serine Protease Cascades 132 5.1.3.3 Cell Proliferation and Motility 132 5.1.3.4 Epithelial Integrity 133 5.1.3.5 Organ Development 135 5.2 Hepsin in Cancer 137 5.2.1 Gain of Oncogenic Function 137 5.2.1.1 Genetic Alterations 137 5.2.1.2 Altered Subcellular Localization 138 5.2.1.3 Oncogenic Hepsin Function in vivo 140 5.2.1.4 How HPN Promotes Cancer 141 5.2.2 Targeting Hepsin in Cancer 143 5.3 Future Prospects 144 5.3.1 Hepsin’s Role as Guardian of Epithelial Integrity 144 5.3.2 Cancer Disease Progression and Metastasis 145 5.3.2.1 Uncontrolled Proteolysis 145 6 Targeting HGF with Antibodies as an Anti-Cancer Therapeutic Strategy 155Dinuka M. De Silva, Arpita Roy and Donald P. Bottaro 6.1 Introduction 155 6.2 HGF Biology 156 6.2.1 HGF Gene Organization and mRNA Transcripts 156 6.2.2 HGF Protein Isoforms and Proteolytic Processing 156 6.2.2.1 HGF Isoforms 156 6.2.2.2 HGF Activation by Proteolytic Processing 159 6.2.3 Key HGF Interactions: Heparan Sulfate Proteoglycans and Met 160 6.2.3.1 Heparan Sulfate Proteoglycans 160 6.2.3.2 Met and Key Intracellular Effectors 161 6.2.4 Major Sites of HGF Expression: Tissues and Organs 162 6.2.5 HGF Function in Development and Adulthood 162 6.2.5.1 hgf or met altered Mice: Embryogenesis 163 6.2.5.2 hgf or met altered Mice: Late Development and Adulthood 163 6.3 HGF in Cancer 164 6.3.1 Lung Cancer 165 6.3.2 Hepatocellular Carcinoma 165 6.3.3 Genitourinary Malignancies 166 6.3.4 Breast Cancer 167 6.3.5 Colorectal and Gastric Carcinomas 167 6.3.6 Papillary Thyroid Carcinoma 168 6.3.7 Brain Tumors 168 6.3.8 Melanoma 169 6.3.9 Head and Neck Squamous Cell Carcinoma 169 6.3.10 Other Malignancies 169 6.4 Anti-HGF Monoclonal Antibodies as Anti-Cancer Therapeutic Candidates 170 6.4.1 Rilotumumab 170 6.4.2 Ficlatuzumab 174 6.4.3 TAK-701 175 6.5 Conclusions and Future Directions 176 Acknowledgements 177 References 177 7 MET and RON Receptor Tyrosine Kinases as Therapeutic Antibody Targets for Cancer 199Mark Wortinger, Jonathan Tetreault, Nick Loizos, and Ling Liu 7.1 MET as a Therapeutic Antibody Target for Cancer 199 7.2 Challenges in Developing MET Therapeutic Antibodies 200 7.3 Anti-MET Antibody Clinical Diagnostics 203 7.4 Anti-MET Antibodies in the Clinic 204 7.4.1 Onartuzumab – Roche 204 7.4.2 Emibetuzumab – Eli Lilly 206 7.4.3 ABT-700 – AbbVie 208 7.4.4 SAIT301 – Samsung 208 7.4.5 ARGX-111 – Argenx 209 7.4.6 Sym-015 – Symphogen 210 7.5 Additional anti-MET Antibodies 210 7.5.1 DN-30 – University of Turin Medical School 210 7.5.2 Other Preclinical Stage anti-MET Antibodies 210 7.6 Summary– anti-MET Antibodies 211 7.7 RON as a Therapeutic Antibody Target for Cancer 211 7.8 Conclusions and Future Outlook 216 References 216 8 Inhibitory Antibodies of the Proteases HGFA, Matriptase and Hepsin 229Daniel Kirchhofer, Charles Eigenbrot, and Robert A. Lazarus 8.1 Anti-Serine Protease Antibodies for Therapeutic Applications 229 8.2 Antibodies can Inhibit Trypsin-Fold Serine Proteases in Diverse Ways 230 8.2.1 Orthosteric Inhibition (Active Site Binding) 231 8.2.2 Allosteric Inhibition 231 8.2.3 Exosite Inhibition 231 8.2.4 Inhibition of Zymogen Activation 231 8.2.5 Cofactor Inhibition 231 8.2.6 Inactivation of Oligomeric Serine Proteases 232 8.2.7 Comparison of Abs with Natural Occurring Protein Modes of Inhibition 232 8.3 Introduction to Antibodies against HGFA, Matriptase and Hepsin 233 8.4 Inhibitory HGFA Antibodies 234 8.5 Inhibitory Matriptase Antibodies 238 8.6 Inhibitory Hepsin Antibodies 239 8.7 Conclusion 240 References 240 9 Inhibitors of the Growth-Factor Activating Proteases Matriptase, Hepsin and HGFA: Strategies for Rational Drug Design and Optimization 247James W. Janetka and Robert A. Galemmo, Jr 9.1 Introduction 247 9.1.1 Proteolytic Control of HGF/MET Oncogenic Signaling 247 9.1.2 Proteolytic Control of MSP/RON Kinase Signaling 248 9.1.3 The Identification of HGF and MSP Converting Enzyme Activity 249 9.2 Small Molecular Weight Inhibitors of HGFA, Matriptase and Hepsin 251 9.2.1 Mechanism-based Inhibitors derived from Substrate Sequences 251 9.2.2 Approved Drugs as Starting Points for Inhibitor Design 257 9.2.3 Retro-Engineering Inhibitors of Related Proteases 258 9.3 Improving Drug-like Properties of the Current Inhibitors: Lessons from the Oral Anti-Coagulants 264 9.4 Conclusion 269 References 270 10 Cyclic Peptide Serine Protease Inhibitors Based on the Natural Product SFTI-1 277Blake T. Riley, Olga Ilyichova, Jonathan M. Harris, David E. Hoke and Ashley M. Buckle 10.1 Introduction: Naturally Occurring Polypeptide Serine Protease Inhibitors 277 10.1.1 Serpins 277 10.1.2 Standard Mechanism Inhibitors 278 10.1.2.1 Kunitz Type 278 10.1.2.2 Kazal Type 278 10.1.2.3 Bowman–Birk Inhibitor (BBI) Family 278 10.2 Selective Inhibitors of Serine Proteases using the Sunflower Trypsin Inhibitor (SFTI-1) as a Scaffold for Rational Drug Design 279 10.2.1 Trypsin 279 10.2.2 Chymotrypsin, Neutrophil Elastase and Cathepsin G 286 10.2.3 Proteasome 286 10.2.4 Matriptase and other Type II Transmembrane Serine Proteases (TTSPs) 286 10.2.5 MASP-1 and MASP-2 286 10.2.6 Other KLKs (KLK5, 7, 14) 287 10.2.7 KLK4 287 10.3 Normal and Pathophysiological Functions of the Human Tissue Kallikrein (KLK)-related Serine Protease Family 288 10.3.1 Physiological Role for KLKs 288 10.3.2 KLKs and their Role in Prostate Cancer Pathogenesis 289 10.3.3 Kallikrein-related Peptidase 4 as a Point of Therapeutic Intervention 290 10.4 Inhibitors of KLK4 Serine Protease 291 10.4.1 Molecular Basis of KLK4 Inhibition by SFTI-1 291 10.4.2 Use of SFTI-1 as a Scaffold in Ligand Design and Optimization 292 10.4.3 Identification of an Optimal Tetrapeptide Substrate 292 10.4.4 SFTI-1FCQR is a Potent Selective Inhibitor of KLK4 293 10.4.4.1 Structural Basis for Potency and Selectivity of SFTI-1FCQR Derivative 293 10.5 Potential Therapeutic Applications and Challenges 294 10.6 Conclusions/Future Directions 297 References 297 11 Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug Discovery 307Marcin Poreba, Paulina Kasperkiewicz, Wioletta Rut and Marcin Drag 11.1 Introduction 307 11.2 Proteases Involved in Cancer 309 11.2.1 Metalloproteases 309 11.2.2 Serine Proteases 310 11.2.3 Cysteine Proteases 311 11.2.4 Aspartic Proteases 311 11.2.5 Threonine Proteases 312 11.2.6 Target Protease Substrates and Inhibitors 312 11.3 Identification and Optimization of Preferred Substrates 313 11.3.1 Positional Scanning of Substrate Combinatorial Libraries (PS-SCL) 313 11.3.2 Peptide Microarrays 318 11.3.3 Hybrid Combinatorial Substrate Library (HyCoSuL) 318 11.3.4 Counter Selection Substrate Library (CoSeSuL) 320 11.3.5 Combinatorial Substrate Synthesis for Aminopeptidase Screening 320 11.3.6 Internally Quenched Fluorescent (IQF) Substrates 321 11.3.7 Phage Display 322 11.3.8 Protease Substrates – Summary 325 11.4 Design of Covalent Inhibitors Based on Substrates 326 11.4.1 Background and General Characteristics of Inhibitors 326 11.4.2 Substrate-based Inhibitor Design and Discovery 327 11.4.3 PS-SCL Applied to Inhibitors other than Substrates 328 11.4.4 Inhibitors from Phage Display Screening and Directed Evolution of Proteins 331 11.5 Anticancer Drugs – How much Information do We Need? 334 11.6 Conclusions 336 Acknowledgements 337 References 337 12 Chemical Probes Targeting Proteases for Imaging and Diagnostics in Cancer 351Pedro Gonçalves and Steven H. L. Verhelst 12.1 Introduction 351 12.2 Chemical Probes for Proteases 352 12.2.1 Substrate-based Probes 352 12.2.2 Activity-based Probes (ABPs) 356 12.2.3 Photo-crosslinking probes 356 12.2.4 Non-Covalent Probes 358 12.3 Molecular Imaging of Cancer 358 12.3.1 Imaging Tumors with Substrate-based Probes 359 12.3.1.1 Preclinical Model Systems 359 12.3.1.2 Clinical Trials 361 12.3.2 Imaging Tumors with ABPs 362 12.3.2.1 Conventional and multimodal ABPs 362 12.3.2.2 Quenched ABPs 364 12.3.2.3 Towards Clinical Applications 365 12.3.3 Imaging Tumors with Affinity-based Reagents 366 12.3.3.1 Preclinical Models 366 12.3.3.2 Clinical Trials 367 12.4 Conclusions 369 Acknowledgements 370 References 371 13 Cancer Diagnostics of Protease Activity and Metastasis 377Timothy J. O’Brien and John Beard 13.1 Introduction 377 13.2 The Proteins Identified from Patient Tumor Profiling 386 13.2.1 Matriptase 386 13.2.2 Hepsin 387 13.2.3 KLK7 387 13.2.4 KLK6 388 13.2.5 KLK8 388 13.2.6 TMPRSS3 388 13.2.7 MMP-7 389 13.3 ELISA Assay Development 389 13.4 The Role of Markers for Cancer Surveillance and Tumor Monitoring (Early Detection) 390 13.5 Cell Signaling and the Cancer Cascade 399 13.6 Conclusions and Future Prospects 400 References 402 14 Roles of Pericellular Proteases in Tumor Angiogenesis: Therapeutic Implications 411Janice M. Kraniak, Raymond R. Mattingly and Bonnie F. Sloane 14.1 Introduction 411 14.2 Initiation of Angiogenesis 412 14.3 Mechanisms of New Blood Vessel Formation 413 14.3.1 Sprouting Angiogenesis 414 14.3.2 Intussesceptive or Non-sprouting Angiogenesis 415 14.3.3 Neovasculogenesis 415 14.3.4 Vascular Mimicry 416 14.4 Pericellular Proteases and Angiogenesis 417 14.4.1 Metalloproteinases: MMPs, ADAMs and ADAM-TS 418 14.4.1.1 MMPs 418 14.4.1.2 ADAMs and ADAM-TS 422 14.4.2 Serine Proteases 424 14.4.3 Cysteine Cathepsins 425 14.4.3.1 Cysteine Cathepsins in Angiogenesis 426 14.5 Novel Approaches for Targeting Tumor Angiogenesis 428 14.6 Summary 432 Acknowledgements 433 References 433 Index 447
£146.25
John Wiley and Sons Ltd Journal of Prosthodontics on Complete and
Book SynopsisThis book is a compilation of articles on complete dentures selected from the Journal of Prosthodontics with the intention of providing the reader with contemporary and relevant information on how the edentulous patient can be better served when fabricating complete dentures. Presents a curated list of the best peer-reviewed articles on complete and removable dentures from the pages of Journal of ProsthodonticsCovers a wide range of treatment scenarios involving fixed and partial denturesOffers a mix of clinical reports, research articles, and reviewsTable of ContentsPreface ix Part I Edentulism and Comorbidities 1 1 Evidence-Based Guidelines for the Care and Maintenance of Complete Dentures: A Publication of the American College of Prosthodontists 3 David Felton, Lyndon Cooper, Ibrahim Duqum, Glenn Minsley, Albert Guckes, Steven Haug, Patricia Meredith, Caryn Solie, David Avery, and Nancy Deal Chandler 2 Classification System for Complete Edentulism 18 Thomas J. McGarry, Arthur Nimmo, James F. Skiba, Robert H. Ahlstrom, Christopher R. Smith, and Jack H. Koumjian 3 Complete Edentulism and Comorbid Diseases: An Update 31 David A. Felton 4 Oral Cancer: A Prosthodontic Diagnosis 48 Michael A. Siegel, Michael A. Kahn, and Mitzi J. Palazzolo 5 The Current and Future Treatment of Edentulism 57 Lyndon F. Cooper 6 Impact of Different Prosthodontic Treatment Modalities on Nutritional Parameters of Elderly Patients 66 Kopal Goel, Saumyendra V. Singh, Pooran Chand, Jitendra Rao, Shuchi Tripathi, Lakshya Kumar, Abbas Ali Mahdi, and Kalpana Singh 7 Conventional Rehabilitation of Edentulous Patients: The Impact on Oral Health-Related Quality of Life and Patient Satisfaction 74 Janice S. Ellis, Nanita D. Pelekis, and J. Mark Thomason 8 Dentures are a Reservoir for Respiratory Pathogens 80 Lindsay E. O’Donnell, Karen Smith, Craig Williams, Chris J. Nile, David F. Lappin, David Bradshaw, Margaret Lambert, Douglas P. Robertson, Jeremy Bagg, Victoria Hannah, and Gordon Ramage Part II Oral Health, Biofilms, and Denture Stomatitis 87 9 Biofilms in the Edentulous Oral Cavity 89 Amit Sachdeo, Anne D. Haffajee, and Sigmund S. Socransky 10 Epidemiology and Etiology of Denture Stomatitis 99 Linda Gendreau and Zvi G. Loewy 11 Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth 112 Sandra Altarawneh, Sompop Bencharit, Luisito Mendoza, Alice Curran, David Barrow, Silvana Barros, John Preisser, Zvi G. Loewy, Linda Gendreau, and Steven Offenbacher 12 The Effect of a Denture Adhesive on the Colonization of Candida Species In Vivo 123 Eunghwan Kim, Carl F. Driscoll, and Glenn E. Minah 13 Effect of Chlorhexidine on Denture Biofilm Accumulation 128 Ingrid Machado de Andrade, Patricia C. Cruz, Cláudia H. Silva-Lovato, Raphael F. de Souza, Maria Cristina Monteiro Souza-Gugelmin, and Helena de Freitas Oliveira Paranhos 14 Evidence Regarding the Treatment of Denture Stomatitis 133 Alexandra Yarborough, Lyndon Cooper, Ibrahim Duqum, Gustavo Mendonça, Kathleen McGraw, and Lisa Stoner Part III Treatment Innovations 149 15 Fabricating Complete Dentures with CAD/CAM and RP Technologies 151 Mehmet Selim Bilgin, Ali Erdem, Osman Sami Aglarci, and Erhan Dilber 16 Part-Digitizing System of Impression and Interocclusal Record for Complete Denture Fabrication 156 Takashi Matsuda, Takaharu Goto, Kazutomo Yagi, Toshiya Kashiwabara, and Tetsuo Ichikawa 17 Enhancing Fracture and Wear Resistance of Dentures/Overdentures Utilizing Digital Technology: A Case Series Report 163 Ahmed Afify and Stephan Haney 18 Design of Complete Dentures by Adopting CAD Developed for Fixed Prostheses 171 Yanfeng Li, Weili Han, Jing Cao, Yuan Iv, Yue Zhang, Yishi Han, Yi Shen, Zheng Ma, and Huanyue Liu 19 Treatment of Edentulism: Optimizing Outcomes with Tissue Management and Impression Techniques 180 Thomas J. Salinas Part IV Functional Parameters and Assessment 191 20 The Position of the Occlusal Plane in Natural and Artificial Dentitions as Related to Other Craniofacial Planes 193 Firas A.M. Al Quran, Abdalla Hazza’a, and Nabeel Al Nahass 21 Predictors of Satisfaction with Dentures in a Cohort of Individuals Wearing Old Dentures: Functional Quality or Patient-Reported Measures? 199 Daiane Cerutti-Kopplin, Elham Emami, Juliana Balbinot Hilgert, Fernando Neves Hugo, Elken Rivaldo, and Dalva Maria Pereira Padilha 22 Analysis of Masticatory Cycle Efficiency in Complete Denture Wearers 206 Marcelo Coelho Goiato, Alício Rosalino Garcia, Daniela Micheline dos Santos, and Paulo Renato Junqueira Zuim 23 Short-Term Assessment of the OHIP-14 Scale on Denture Wearers Using Adhesives 211 Gregory Polyzois, Panagiotis Lagouvardos, Christos Partalis, Panagiotis Zoidis, and Hector Polyzois 24 Comparisons of Patient Satisfaction Levels with Complete Dentures of Different Occlusions: A Randomized Clinical Trial 220 Mohhamadjavad Shirani, Ramin Mosharraf, and Mohammadkazem Shirany 25 Factors Associated with Successful Denture Therapy 229 Roberta L. Diehl, Ulrich Foerster, Venita J. Sposetti, and Teresa A. Dolan Part V Esthetic Considerations 237 26 Perception of Esthetic Impact of Smile Line in Complete Denture Wearers by Different Age Groups 239 Matheus Melo Pithon, Leandro Pereira Alves, Matheus da Costa Prado, Rener Leal Oliveira, Matheus Souza Campos Costa, Raildo da Silva Coqueiro, João Milton Rocha Gusmão, and Rogério Lacerda Santos 27 Assessment of the Ability to Relate Anterior Tooth Form and Arrangement to Gender 245 Fernanda Ferreira Jassé, Josiane Vilhena Corrêa, Andréa Ferreira Santos da Cruz, Mauro José Pantoja Fontelles, Andiara Ribeiro Roberto, José Roberto Cury Saad, and Edson Alves de Campos 28 Guidelines for Maxillary Incisal Edge Position—A Pilot Study: The Key is the Canine 250 Carl E. Misch 29 Nasal Width as a Guide for the Selection of Maxillary Complete Denture Anterior Teeth in Four Racial Groups 255 Fabiana Mansur Varjão and Sergio Sualdini Nogueira 30 Qualitative and Quantitative Guides to the Selection and Arrangement of the Maxillary Anterior Teeth 261 Douglas A. Hock Index 267
£98.75
John Wiley and Sons Ltd Complications of PainRelieving Procedures
Book SynopsisA comprehensive exploration of potential complications arising from interventional pain therapies. In Complications of Pain-Relieving Procedures: An Illustrated Guide, a team of distinguished pain specialists delivers a straightforward, extensively illustrated, and step-by-step guide to managing complications arising out of pain-relieving procedures and interventions. The book offers essential assistance to physicians by combining a wide range of potential complications into a single, comprehensive resource suited to quick review in real time. It will help readers determine the clinical steps necessary to avoid long-term consequences for patients. This illustrated reference contains numerous images of the possible complications of specific procedures. Each chapter includes discussions of the anatomy of the target nerve, plexus or space, indications for the procedure, technical approaches with pictures, potential complications, and strategies for preventing compliTable of ContentsSection Editors xii List of Contributors xiii Foreword xx Gabor B. Racz Foreword xxii Ricardo Ruiz – Lopez Preface xxiv Acknowledgments xxvi Section 1: Basic Principles 1 1 The Importance of Studying Complications in Pain Medicine 3 Peter S. Staats and Serdar Erdine 2 History of Interventional Pain Procedures 8 Serdar Erdine and Peter S. Staats 3 Ethics of Interventional Pain Management 18 Serdar Erdine 4 Clinical Assessment of Patients to Decrease Risk 21 Vittorio Schweiger, Massimo Parolini, Alvise Martini, and Enrico Polati 5 Medical Legal Issues in Pain Management 27 Standiford Helm and Raymond McMahon 6 Complications of Opiate Therapy 32 Elie Sader, Steven Calvino, and Christopher Gharibo 7 Complications in the Pharmacologic Approach of Pain 38 Kris C.P. Vissers, Priodarshi Roychoudhury, and Lakshmi Koyyalagunta 8 Complications of Sedation in Painful Procedures 48 Ramsin Benyamin 9 Complications of Injectable Agents Used Intraoperatively 55 Karolina M. Szadek, Remko Liebregts, A. Long Liem, and Monique A.H. Steegers 10 Complications of Cryoneuroablation 63 Andrea Trescot 11 Complications of Radiofrequency Ablation Procedures 73 Anand Thakur C., Serdar Erdine, and Peter S. Staats 12 Infection Control 80 Liong Liem, Said Shofwan, Grady Janitra, and Sholahuddin Rhatomy 13 Radiation Safety for Interventional Pain Physicians 90 Vikram B. Patel 14 Bleeding Complications 97 Anthony H. Guarino and Neill Wright Section 2: Complications of Cranial Procedures 101 15 Complications of Percutaneous Trigeminal Ganglion Procedures 103 Serdar Erdine 16 Complications of Sphenopalatine Ganglion Block 114 Benjamin Ashworth and Miles Day 17 Complications of Percutaneous Block and Lesioning of the Glossopharyngeal Nerve 121 Serdar Erdine Section 3: Complications of Neck Procedures 127 18 Complications of Occipital Nerve Block and Radiofrequency Lesioning 129 Can Eyigor and Meltem Uyar 19 Complications of Cervical Epidural Steroid Injection 136 Ariana M. Nelson and Honorio T. Benzon 20 Complications of Cervical Facet Procedures 146 Jan van Zundert and Maarten van Eerd 21 Complications of Cervical Discography 152 Wenxi (Richard) Gao and Srdjan S. Nedeljković 22 Cervical Epidural Lysis of Adhesions 158 Gabor Bela Racz, Gabor J. Racz, Mohammad Javed Tariq, and Carl E. Noe 23 Complications of Stellate Ganglion Block (SGB) 167 Serdar Erdine and Peter S. Staats Section 4: Complications of Thoracic Procedures 179 24 Complications of Thoracic Interlaminar Steroid Injection 181 Mert Akbaş and Gözde Dağıstan 25 Complications of Cervical and Thoracic Transforaminal Epidural Block 188 Arun Bhaskar and Athmaja Thottungal 26 Complications of Thoracic Facet Blocks and Ablations 199 Robert Chow, Melanie G. Wood, and Milan P. Stojanovic 27 Complications of Thoracic Discography 206 Fabricio Assis, Joao Henrique Araujo, and Francisco Morato Dias Abreu 28 Complications of Thoracic Sympathetic Block 214 Fabricio Assis, Carlos Marcelo de Barros, Tainá Melo Vieira Motta Pereira, and Thalita Marqueze 29 Complications of Intercostal Blocks and Ablations 223 Charles Amaral de Oliveira, Thais Khouri Vanetti, and Karen Santos Braghiroli 30 Complications of Thoracic Procedures 227 Elaine Gomes Martins, Thiago Nouer Frederico, and André Mansano 31 Complications of Splanchnic and Celiac Plexus Block 236 Serdar Erdine Section 5: Complications of Lumbar Spine Procedures 247 32 Complications of Lumbar Interlaminar Steroid Injection 249 Mert Akbaş and Gözde Dağıstan 33 Complications of Lumbar Transforaminal Blocks 258 Jay Karri, Anuj Marathe, Rinoo Shah, and Scott Glaser 34 Complications of Lumbar Facet and Medial Branch Blocks and Ablations 267 Gözde Dağıstan and Mert Akbaş 35 Complications of Lumbar Sympathetic Block 274 E. Alp Yentür 36 Complications of Lumbar Provocation Discography 280 Ramsin Benyamin 37 Complications of Basivertebral Nerve Ablation 290 Ameer Ali, Melissa Lau, Michael DePalma, and Douglas Beall 38 Complications of Vertebroplasty and Kyphoplasty for Thoracic and Lumbar Procedures 298 Douglas P. Beall, Jordan E. Brasuell, Andrew W. Favre, Brooks M. Koenig, M. Ali Khan, Edward S. Yoon, Trevor R. Magee, Drake Stockard, Joseph D. Kinsinger, Saad A. Khan, William H. Eskew, and James R. Webb Section 6: Complications of Pelvic and Sacral Procedures 329 39 Complications of Caudal Epidural Lysis of Adhesions 331 Gabor Bela Racz, Gabor J. Racz, Mohammad Tariq, and Carl E. Noe 40 Complications of Epiduroscopic Procedures 339 Altan Şahin 41 Superior Hypogastric Plexus Block 351 Ricardo Plancarte Sánchez and Marcela Sámano García 42 Complications of Ganglion Impar Block 360 Ricardo Plancarte Sánchez, Angel Manuel Juárez Lemus, Berenice Carolina Hernández Porras, and María del Rocío Guillén Nuñez 43 Complications of Sacroiliac Joint Block and Ablation 369 Aaron P. Bloom and Clarence Shannon Section 7: Complications of Peripheral Blocks 377 44 Complications of Suprascapular Nerve Procedures 379 María Luz Padilla del Rey, Eleni Episkopou, and Agnes R. Stogicza 45 Complications of Genicular Nerve Blocks and Ablations 387 Kris Ferguson and Hemant Kalia 46 Complications of Lateral Obturator and Lateral Femoral Nerve Block and Radiofrequency Ablation for Hip Denervation 392 Leonardo Kapural and Taif Mukhdomi 47 Complications of Obturator Nerve Block 397 Kristof Racz, María Luz Padilla del Rey, and Agnes R. Stogicza 48 Complications of Lateral Femoral Cutaneous Nerve Procedures 405 Alan Berkman, María Luz Padilla del Rey, and Agnes R. Stogicza 49 Complications of Pudendal Nerve Procedures 412 María Luz Padilla del Rey, Alan Berkman, and Agnes R. Stogicza Section 8: Complications of Neuromodulation 421 50 Complications of Intrathecal Drug Delivery Systems and Drugs Used 423 Alyson M. Engle, Mark N. Malinowski, Jonathan M. Hagedorn, and Timothy R. Deer 51 Complications of Spinal Cord Stimulation 439 İbrahim Aşik and Ümit Akkemik 52 Complications of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Neuropathic Pain 449 Robert M. Levy 53 Complications of Peripheral and Field Stimulation 460 Priodarshi Roychoudhury and Peter Staats 54 Complications of Occipital and Trigeminal Nerve Stimulation 469 Konstantin V. Slavin Section 9: Complications of Procedures on Regenerative Medicine and Advanced Interventions 477 55 Complications in Regenerative Medicine 479 Ricardo Ruiz-Lopez, Yu Chuan Tsai, and Mattia Squarcia 56 Complications of Sacroplasty 493 Harold Cordner 57 Complications of Femoroplasty 501 Ricardo Plancarte, Berenice Carolina Hernández-Porras, Angel Juárez Lemus, and Erika C. Lopez Montes 58 Complications of Percutaneous Cordotomy 508 Ibrahim Yegül 59 Complications of Minimally Invasive Lumbar Decompression (MILD) 517 David W. Lee and Jason Pope 60 Complications of Interspinous Decompression 524 Sean li 61 Complications of Sacroiliac Joint Stabilization 529 Adam Rupp and Dawood Sayed 62 Complications of Intradiscal Therapeutic Procedures 537 Shrif Costandi and Nicholas Prayson 63 Complications of Trigger Point Injection 547 Yu Chuan Tsai and Ricardo Ruiz-Lopez 64 Complications of Percutaneous Spinal Lumbar Endoscopy (PELD) 555 Ricardo Ruiz-Lopez, Ovidiu Palea, and Teodor Cristea 65 Complications of Percutaneous Lumbar Extraforaminotomy 564 Sang Chul Lee, Ricardo Ruiz-Lopez, and Won-Joong Kim Index 574
£135.00
John Wiley & Sons Inc Understanding the Science and Practice of Public
Book SynopsisA civically minded approach to public health, perfect for students on any career path Understanding the Science and Practice of Public Health is an exciting new textbook designed specifically for introductory public health courses at the college level. In a world rapidly being challenged by climate change, starvation, water shortages, and epidemicsand in a nation plagued by obesity, diabetes, early onset cardiovascular disease, cancer, and gun violencethis book provides students with crucial information that they'll need to understand what's going on around them. Thematically, this book focuses on the viewpoint that We the People have the ultimate responsibility to collectively assure the conditions that allow people to successfully seek health and well-being. Public health is a public responsibility (a maxim often repeated in the book), and college and university students must be fully informed to optimally meet this vital civic obligation. Written to be accessible to students in any major, this unique text prepares students to participate in the daily actions needed (including advocacy and support of health-related regulations and policy) to become participants in public health practice, rather than passive recipients. Readers will: Get an accessible introduction to the most pressing public health issues of todayLearn how public health is promoted in society using real-world examplesBecome knowledgeable about public health so you can make informed decisions at the voting booth and in daily life Discover the practice of public health as it applies to pandemics, substance abuse, climate change, gun violence, and moreThe science and practice of public health depends on a well-informed and highly engaged population of civic-minded adults. This book will enable students' enthusiastic participation in savings lives and promoting healthno matter what career path they decide to pursue.Table of ContentsForeword vii Preface ix Chapter 1 The COVID-19 Pandemic: A Portrait of an Epidemic 1 Chapter 2 Changing Lives a “Million at a Time”: Public Health Is Very Different Than the Medical Profession 25 Chapter 3 The Evolution of Public Health Practice 45 Chapter 4 How Does Public Health Work? The Example of Tobacco Control 63 Chapter 5 America’s Obesity and Cardiovascular Disease Epidemics: Possible Public Health Solutions 83 Chapter 6 Preventing Diabetes: A Public Health Priority 105 Chapter 7 Averting Cancer Rather Than Waiting to Treat It 123 Chapter 8 Excessive Alcohol Use: How Can It Be Reduce data Population Level? 141 Chapter 9 Solving the U.S. Opioid Crisis: A Public Health Challenge 155 Chapter 10 HIV in the United States–What Else Can We Do? 173 Chapter 11 Preventing Gun Violence and Promoting Highway Safety: A Study of Stark Contrasts 195 Chapter 12 Climate Change: The Importance of Water 215 Chapter 13 Climate Change: Implications Regarding Food 233 Chapter 14 Over population and the Prevention of Unintended Pregnancy 255 Chapter 15 Emerging Diseases and the Need for Vaccine Research 271 Annotated Answers to Practice Questions 289 Epilogue 317
£71.25
Flatiron Books The Unseen Body
Book Synopsis
£22.39
Flatiron Books The Unseen Body
Book SynopsisA fascinating, lyrical book... Reisman''s experiences in other cultures bring a richness and depth to The Unseen Body. The way he thinks about the body and medicinethe rivers and tributaries, the flowing and unclogging, the top-down organization of the brainis extraordinary!Mary RoachIn this fascinating journey through the human body and across the globe, Dr. Reisman weaves together stories about our insides with a unique perspective on life, culture, and the natural world.Jonathan Reisman, M.D.a physician, adventure traveler and naturalistbrings readers on an odyssey navigating our insides like an explorer discovering a new world with The Unseen Body. With unique insight, Reisman shows us how understanding mountain watersheds helps to diagnose heart attacks, how the body is made mostly of mucus, not water, and how urine carries within it a tale of humanity's origins.Through his offbeat adventures in healthcare and travel, Reis
£16.14
McGraw-Hill Education Harrisons Principles of Internal Medicine
Book Synopsis MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithmsRecognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrisonâs Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.Essential for practice and education, the landmark 20th Edition features:<
£999.99
McGraw-Hill Education The New Fat Flush Cookbook
Book SynopsisThe cookbook that changed dieting as we know itâupdated with hundreds of great recipes based on the newly-revised Fat Flush protocolsFor the first time in 15 years, the New York Times bestseller The Fat Flush Plan has been completely updated to reflect the latest research and cutting-edge nutritional science. The New Fat Flush Cookbook perfectly complements the newly-revised program protocols. This valuable resource is packed with more than 200 brand-new Fat Flush recipes and snacks, many of which can be prepared in less than 20 minutes. Youâll discover great ideas for delicious, simple meals with wholesome ingredients and flavored with unique fat-burning and cleansing herbs and spices. Author Ann Gittleman covers all the latest dietary trends and science concerning higher fat diets (Paleo and Ketogenic), fasting/cleansing (green drinks), the microbiome, bile, hormonal fluctuations, gluten and grain avoidance, nutrient defici
£21.84
McGraw-Hill Education The New Fat Flush Journal and Shopping Guide
Book SynopsisFat Flush Has Never Been Easier with this Companion Journal!For more than two decades, The Fat Flush Plan has helped millions of people lose weight, detox, and improve their overall health and well-being. The NEW Fat Flush Journal and Shopping Guide compliments The NEW Fat Flush Plan perfectly, incorporating a new journal format, personal tracker, refreshed shopping guide, and gratitude lists. Here, youâll find the tools needed to track your meals, supplements, measurements, sleep patterns, and more. Use the journal to chart your progress and also identify unconscious physical or emotional roadblocks to your dieting goals. The up-to-date Fat Flush shopping list includes newly-approved foods and specific brands names that are also appropriate for vegan, vegetarian, paleo, gluten-free, and dairy-free diets. The New Fat Flush Journal and Shopping Guide includes:
£15.19
McGraw Hill Education Acquiring Medical Language
£162.93
McGraw-Hill Education Pharmacotherapy Principles and Practice Fifth
Book SynopsisThe unique orientation to pharmacotherapy found in the classic Pharmacotherapy: A Pathophysiologic Approach distilled to a tightly focused full-color resource Pharmacotherapy Principles & Practice, Fifth Edition uses a solid evidence-based approach to teach readers how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything readers need to gain an in-depth understanding of the underlying principles of the pharmacotherapy of diseaseâand their practical application. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice, and laboratory values are expressed as both conventional units and SI units. Importantly, all chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians widely recognized as authorities in their f
£152.94
McGraw-Hill Education U.S. Public Pension Handbook A Comprehensive
Book Synopsis The first comprehensive guide to mastering the roles and responsibilities of a public pension fiduciary in the U.S. In an ever-changing financial and political landscape, your job as a public pension fiduciary continues to get more difficult. Now, you have the help you need. U.S. Public Pension Handbook is the only one-stop resource that covers the various areas of public pension policy design, governance, investment management, infrastructure, accounting, and law. This comprehensive guide presents critical data, information, and insights in topic-specific, easy-to-understand waysâproviding the knowledge you need to elevate your expertise and overall contribution to your pension plan or system. U.S. Public Pension Handbook covers: âTodayâs domestic and global public pension marketplace â
£55.09
McGraw-Hill Education DeGowins Diagnostic Examination 11th Edition
Book SynopsisThe classic guide to the undifferentiated patientâenhanced by new cases A Doody's Core Title for 2024 & 2023! Technological advances have taken testing and imaging to remarkable new placesâyet establishing patient history and performing physical examinations are more important now than ever. This classic guide has been showing students and clinicians how to approach the diagnostic process thoughtfully and systematically for decadesâand this revised edition brings you completely up to date. Part physical examination primer, part differential diagnosis tool, DeGowin's Diagnostic Examination provides the information and insights you need to make accurate, evidence-based diagnostic hypotheses. Covering all physical exam techniques and procedures, this updated edition shows how to collect clinical findings gleaned from the physical examination and synthesize them into a differential diagnosis. â Covers the latest de
£58.49
McGraw-Hill Education FRICTIONâThe Untapped Force That Can Be Your Most
Book SynopsisNAMED A "BEST BUSINESS BOOK OF 2019" by strategy+business Annually, $4.6 trillion of merchandise is left in abandoned e-commerce shopping carts. Every year, the U.S. economy loses $3 trillion dollars in productivity due to excess bureaucracy. Red tape and over-complicated licenses have contributed to Chinaâs GDP exceeding Indiaâs by $82 trillion over the span of just three decades.If youâre a business leader, these statistics should give you nightmares. According to science-based marketing and business expert Roger Dooley, they illustrate the real and growing threat of âœfriction,â which he defines as the unnecessary expenditure of time, effort, or money in performing a task. In today's high-speed, customer-empowered world, the levels of swiftness and efficiency of business transactions will determine ultimate succeTable of ContentsIntroduction Prologue: Engine of Disruption 1 The Friction Evangelist 2 Retail Disruption—Nineteenth and Twentieth Centuries 3 Transportation Disruption 4 Digital Disruption 5 The Science of Friction 6 Decision Friction 7 Customer Experience and Friction 8 Technology Friction 9 Friction Within Your Business 10 A World of Friction 11 Bureaucrats and Red Tape Warriors 12 Taxes and Beyond 13 Habits and Productivity 14 Friction Design 15 Nonprofit Friction 16 Friction Everywhere Conclusion: Go Forth and Find Friction Appendix: The Persuasion Slide Acknowledgments Notes Index
£20.89
McGraw-Hill Education WorkbookAnthology for use with Harmony in Context
Book Synopsis
£131.04
McGraw-Hill Education Holes Essentials of Human Anatomy Physiology
Book SynopsisDesigned for the one-semester anatomy and physiology course, Hole's Essentials of Human Anatomy and Physiology assumes no prior science knowledge and supports core topics with clinical applications, making difficult concepts relevant to students pursuing careers in the allied health field. The Learn, Practice, and Access system is used throughout the text and digital content for immediate application. "Learning" outcomes begin the chapter and set the stage for what students will learn, "Practice" questions conclude each major section and help students recall the information theyâve consumed, and "Assess" end-of-chapter resources allow students to confirm their accurate recall of what they learned and practiced. The learn, practice, and assess system is highly effective in providing students with a solid understanding of the important concepts in anatomy and physiology.Table of ContentsUnit 1 Levels of Organization1 Introduction to Human Anatomy and Physiology2 Chemical Basis of Life3 Cells4 Cellular Metabolism5 TissuesUnit 2 Support and Movement6 Integumentary System7 Skeletal System8 Muscular SystemUnit 3 Integration and Coordination9 Nervous System10 The Senses11 Endocrine SystemUnit 4 Transport12 Blood13 Cardiovascular System14 Lymphatic System and ImmunityUnit 5 Absorption and Excretion15 Digestion and Nutrition16 Respiratory System17 Urinary System18 Water, Electrolyte, and Acid-Base BalanceUnit 6 The Human Life Cycle19 Reproductive Systems20 Pregnancy, Growth, Development, and Genetics
£999.99
McGraw-Hill Education Graber and Wilburs Family Medicine Examination
Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Master every facet of family medicine with this comprehensive, engaging, meticulously updated guide and enjoy doing it! This is the go-to resource for students and practitioners Whether youâre studying for the boards or USMLE or looking to boost your professional knowledge, Family Medicine Examination & Board Review delivers everything you need to move to the next level of your career. Packed with 350+ progressive cases and thousands of questions with right and wrong answers explained in detail, this matchless guide provides both the information and practice required for complete mastery of the subject. This new edition gets you fully up to date with critical information on a host of topicsâ
£85.49
McGraw-Hill Education CURRENT Medical Diagnosis and Treatment 2020
Book SynopsisThe #1 annually updated general medical text â delivering the diagnostic tools most relevant to daily practiceCURRENT Medical Diagnosis & Treatment is the most comprehensive, reliable, and timely reference available to answer common questions that arise in everyday clinical practice. Readers will find authoritative, evidence-based coverage of more than 1,000 diseases and disorders along with a concise, yet thorough synopsis of diagnosis and treatment. Written in a clear, easy-to-read style, this trusted classic covers all aspects of outpatient and inpatient care and includes discussion of new developments and breakthroughs in medicine. Presented in full colour, CMDT covers every aspect of general medicine, with an emphasis on prevention and cost-effective strategies.âMarket: Internal medicine practitioners (77,000), family physicians (74,000), internal medicine residents (23,000), family medicine residents (
£65.99
McGraw-Hill Education McGrawHills EMT Flashcards Second Edition
Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.324 succinct, detailed flashcards provide you need to ace the EMT certification exam and build your professional expertiseWith the convenience of portability and the comprehensiveness of a medical text, the new edition of McGraw-Hill's EMT Flashcards covers the essential concepts you need to masterâwhether youâre studying for certification or brushing up on your skills. Covering everything from medical/legal issues to patient assessment to airway management to treating serious injuries, the flashcards are organized into seven sections for focused study. Each durable color card features a question on one side and a detailed answer on the other, with icons that h
£29.56
McGraw-Hill Education Pretest Neurology 10th edition
Book SynopsisAce Your Clerkship and Shelf Exam!PreTest is a name you can trust for exam review. Neurology: PreTest is the perfect way to assess your knowledge for the neurology shelf exam and the USMLE Step 2 CK exam. Youâll find hundreds of Board questions and answers that address the clerkshipâs core competencies, along with detailed explanations of both correct and incorrect answers. All questions have been reviewed by students who completed their clerkships and passed the USMLE Step 2 CK examâand know what it takes to succeed. Hundreds of practice questions and answers, reflecting the content and terminology youâll see on your exams For common neurologic conditions, pathophysiologic explanations have been added, as well as diagnostic pearls and management strategies Fully updated to include the latest AAN treatment guidelines, neurologic therapeutics and neurologic electrodiagnostic and imaging techniques Detailed explanations fo
£44.74
McGraw-Hill Education CURRENT Medical Diagnosis and Treatment 2021
Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.The 60th anniversary edition of the most popular, relied-upon guide to internal medicine For 60 years, CURRENT Medical Diagnosis and Treatmentâthe flagship volume of the renowned Lange medical seriesâhas been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Covering the latest clinical developments in all facets of medicine and fully focused on bedside clinical issues, this new edition provides completely the latest guidelines, reference, drug prices, approved drugs, and evidence-based coverage of more than 1,000 diseases and disordersâall formatted to enable you to find the answers you need quickly and effortlessly. This landmark guide covers inpatient a
£64.59
McGraw-Hill Education Loose Leaf for Medical Language Accelerated
Book Synopsis
£105.12
McGraw-Hill Education Student Workbook for Medical Assisting
Book Synopsis
£94.50
McGraw-Hill Education Laboratory Manual by Wise for Saladins Anatomy
Book SynopsisTable of ContentsLABORATORY EXERCISES1 Introduction to Lab Science, Measurement, and Chemistry2 Organs, Systems, and Organization of the Body3 Microscopy4 Cell Structure and Function5 Tissues6 Integumentary System7 Introduction to the Skeletal System8 Axial Skeleton9 Appendicular Skeleton 10 Joints11 Axial Muscles 1: Muscles of the Head and Neck12 Axial Muscles 2: Muscles of the Trunk13 Appendicular Muscles 1: Muscles of the Upper Limb14 Appendicular Muscles 2: Muscles of the Lower Limb15 Muscle Physiology16 Nervous Tissue, the Spinal Cord, and Spinal Nerves17 The Brain and Cranial Nerves18 Nervous System Physiology—Stimuli and Reflexes19 Cutaneous Senses20 Taste and Smell21 Eye and Vision22 Ear, Hearing, and Equilibrium23 Endocrine System24 Blood25 Blood Tests and Typing26 Anatomy of the Heart27 Electrical Conductivity of the Heart28 Functions of the Heart29 Blood Vessels 1: Introduction to Blood Vessels and Blood Vessels of the Axial Region30 Blood Vessels 2: Vessels of the Appendicular Region31 Lymphatic System32 Blood Vessels and Blood Pressure33 Anatomy of the Respiratory System34 Respiratory Physiology35 Physiology of Exercise and Pulmonary Health36 Urinary System37 Urinalysis38 Anatomy of the Digestive System39 Digestive Physiology40 Male Reproductive System41 Female Reproductive System and Early Development
£166.83
McGraw-Hill Companies Loose Leaf for Acquiring Medical Language
Book Synopsis
£182.51
McGraw-Hill Education First Aid for the Psychiatry Clerkship Sixth
Book SynopsisThe best selling resource for the psychiatry clerkshipExcel on your rotation, impress on the wards, and score your highest on the shelf exams with this best-selling reference. This new edition of First Aid for the Psychiatry Clerkship has been updated with the latest clinical perspectives and research. Ask just about any student who has been through their psychiatry rotation and they will tell you that THIS was the resource they turned to. It not only aligns with national clerkship curricula, but also follows the shelf exam blueprint and is full of helpful mnemonics, ward tips, exam tips, and integrated mini-cases. The chapter âœHow to Succeed in the Psychiatry Clerkshipâ provides a solid foundation for setting new clerks up for success in their psychiatry rotation. The text highlights all of the important topics, presenting a clear, concise review of psychiatry with a strong clinical emphasis tha
£47.49
McGraw-Hill Education Lab Manual to accompany McKinleys Anatomy
Book SynopsisAnatomy & Physiology: An Integrative Approach Laboratory Manual, fourth edition, continues to serve as a resource for students both in and out of the lab, providing a âœhow-toâ guide for learning anatomy and physiology. The interactive pages within serve as a stand-alone manual, while also complementing the textbook, McKinley/OâLoughlin/Bidle: Anatomy Physiology: An Integrative Approach, fourth edition.Table of ContentsChapter 1 The Laboratory EnvironmentChapter 2 Orientation to the Human BodyChapter 3 The MicroscopeChapter 4 Cell Structure and Membrane TransportChapter 5 HistologyChapter 6 IntegumentChapter 7 The Skeletal System: Bone Structure and FunctionChapter 8 The Skeletal System: Axial SkeletonChapter 9 The Skeletal System: Appendicular SkeletonChapter 10 ArticulationsChapter 11 The Muscular System: Muscle Structure and FunctionChapter 12 The Muscular System: Axial MusclesChapter 13 The Muscular System: Appendicular MusclesChapter 14 Nervous TissuesChapter 15 The Brain and Cranial NervesChapter 16 The Spinal Cord, Spinal Nerves, and ReflexesChapter 17 The Autonomic Nervous SystemChapter 18 General and Special SensesChapter 19 The Endocrine SystemChapter 20 The Cardiovascular System: BloodChapter 21 The Cardiovascular System: The HeartChapter 22 The Cardiovascular System: Vessels and CirculationChapter 23 The Lymphatic System and ImmunityChapter 24 The Respiratory SystemChapter 25 The Urinary SystemChapter 26 The Digestive SystemChapter 27 The Reproductive System and Early DevelopmentChapter 28 Cat Dissection ExercisesChapter 29 Fetal Pig Dissection Exercises
£159.44
McGraw-Hill Education Laboratory Manual by Wise for Seeleys Anatomy and
Book Synopsis
£165.99
McGraw-Hill Education Pocket Guide for Medical Assisting Administrative
Book Synopsis
£47.45
OM Book Service Loose Leaf for You Code It
Book Synopsis
£113.14
McGraw-Hill Education CURRENT Medical Diagnosis and Treatment 2024
Book SynopsisThe #1 annually updated general medical textâpresents the most important diagnostic and treatment recommendations as well as the most useful new clinical developments in every field of adult medicine.For more than six decades, CURRENT Medical Diagnosis & Treatment has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Written by top experts in their fields, this unmatched guide is formatted in a way that enables readers to find the answers they need quickly and easily.CURRENT Medical Diagnosis & Treatment 2024 reflects the latest developments in medicine, guidelines, references, and more. Youâll find authoritative, evidence-based coverage of more than 1,000 diseases and disorders along with a concise, yet thorough synopsis of diagnosis and treatment. This trusted classic covers all aspects of outpatient and inpatient care and includes discussion of new
£76.94
McGraw-Hill Education Laboratory Manual by Wise for Saladins Anatomy
Book Synopsis
£166.93
McGraw-Hill Education Laboratory Manual to accompany Holes Essentials
Book SynopsisThis laboratory manual was prepared to supplement the textbook Holeâs Essentials of Human Anatomy and Physiology, Fourteenth Edition, by Dr. Charles Welsh and Cynthia Prentice-Craver. As in the textbook, the laboratory manual is designed for students with minimal backgrounds in the physical and biological sciences pursuing careers in professional health fields.The laboratory manual contains forty-nine laboratory exercises and reports closely integrated with the chapters of the textbook. The exercises are planned to illustrate and review the anatomical and physiological facts and principles presented in the textbook and to help students investigate some of these ideas in greater detail.Table of ContentsFundamentals of Human Anatomy and PhysiologyExercise 1Scientific Method and MeasurementsExercise 2Body Organization and TerminologyExercise 3Chemistry of LifeExercise 4Care and Use of the MicroscopeCellsExercise 5Cell Structure and FunctionExercise 6Movements Through MembranesExercise 7Cell CycleTissuesExercise 8Epithelial TissuesExercise 9Connective TissuesExercise 10Muscle and Nervous TissuesIntegumentary SystemExercise 11Integumentary SystemSkeletal SystemExercise 12Bone StructureExercise 13Organization of the SkeletonExercise 14SkullExercise 15Vertebral Column and Thoracic CageExercise 16Pectoral Girdle and Upper LimbExercise 17Pelvic Girdle and Lower LimbExercise 18Joint Structure and MovementsMuscular SystemExercise 19Skeletal Muscle Structure and FunctionExercise 20Muscles of the Head and Neck Exercise 21Muscles of the Chest, Shoulder, and Upper LimbExercise 22Muscles of the Abdominal Wall and Pelvic FloorExercise 23Muscles of the Hip and Lower LimbSurface AnatomyExercise 24Surface AnatomyNervous SystemExercise 25Nervous Tissue and NervesExercise 26Spinal Cord and Meninges Exercise 27Reflex Arc and ReflexesExercise 28Brain and Cranial NervesExercise 29Dissection of the Sheep BrainSpecial SensesExercise 30Ear and HearingExercise 31Eye StructureExercise 32Visual Tests and DemonstrationsEndocrine SystemExercise 33Endocrine Histology and Diabetic PhysiologyCardiovascular SystemExercise 34Blood Cells and Blood TypingExercise 35Heart StructureExercise 36Cardiac CycleExercise 37Blood Vessel Structure, Arteries, and VeinsExercise 38Pulse Rate and Blood PressureLymphatic SystemExercise 39Lymphatic SystemDigestive SystemExercise 40Digestive OrgansExercise 41Action of a Digestive EnzymeRespiratory SystemExercise 42Respiratory OrgansExercise 43Breathing and Respiratory VolumesUrinary SystemExercise 44Urinary OrgansExercise 45UrinalysisReproductive SystemExercise 46Male Reproductive SystemExercise 47Female Reproductive SystemExercise 48GeneticsSupplemental Laboratory Exercise Laboratory ExerciseBlood Testing
£143.99
McGraw-Hill Companies You Code It Abstracting Case Studies Practicum
Book Synopsis
£150.77
McGraw-Hill Companies Looseleaf for Child Development An Introduction
Book Synopsis
£91.35
McGraw-Hill Companies Loose Leaf for Medical Terminology Learning
Book Synopsis
£114.16
John Wiley & Sons Inc ABC of Pain
Book SynopsisChronic pain is a very common problem, impacting on many patients. Assessment and management can be challenging. The ABC of Pain focuses on the pain management issues often encountered in primary care.Table of ContentsContributors vii Preface ix 1 Epidemiology of Chronic Pain 1 Blair H Smith and Nicola Torrance 2 Pain Mechanisms 5 Carole Torsney and Susan Fleetwood-Walker 3 Evaluation of the Patient in Pain 11 Dennis C Turk and Kimberly S Swanson 4 Chronic Musculoskeletal Pain 16 Paul Dieppe 5 Management of Low Back Pain 20 James Campbell and Lesley A Colvin 6 Neuropathic Pain 25 Lesley A Colvin and Suzanne Carty 7 Visceral Pain 31 James Maybin and Michael G Serpell 8 Post-surgical Pain 37 Susan Nimmo and Lesley Dickson 9 Headache and Orofacial Pain 42 Anne MacGregor and Joanna M Zakrzewska 10 Cancer Pain 48 Marie Fallon 11 Treating Pain in Patients with Drug-dependence Problems 54 Jane C Ballantyne 12 Pain in Children 60 Suellen M Walker 13 Pain in Older Adults 65 Debra K Weiner 14 Pain in Pregnancy 69 George R Harrison 15 Psychological Aspects of Chronic Pain 73 David Gillanders 16 Interventional Procedures in Pain Management 79 Dominic Hegarty and Damian Murphy 17 The Role of Physiotherapy in Pain Management 86 Paul J Watson 18 The Role of Transcutaneous Electrical Nerve Stimulation (TENS) in Pain Management 91 Mark I Johnson 19 Complementary and Alternative Strategies 99 Margaret Cullen and Fiona MacPherson 20 Opioids in Chronic Non-malignant Pain 103 Eija Kalso Index 109
£34.95
John Wiley and Sons Ltd A Practical Approach to Cardiovascular Medicine
Book SynopsisWritten, reviewed, and edited in a collaborative effort by cardiology fellows and faculty of one of the most prestigious academic centers in the country, this concise volume gives cardiology fellows the book they have long needed.Trade Review“Practical and easily accessible at the time of decision making, the book relays important concepts through concise and to-the-point pearls and by utilizing algorithm charts and illustrations.” (Kingbook73's Medical Ebook and Video Collection, 15 October 2014) "This is a very good source of general information about current cardiovascular practice on a basic level. It is easy to read and follow with a special focus on contemporary guidelines and practices. What makes this book attractive is that it is easy to read." (Doody's, 27 January 2012) "An accurately titled short reference work, this book is leading out in seven sections of 29 chapters dealing with prevention, clinical aspects of a heart attack, heart failure, valvular disease and vascular disease, arrhythmias and sudden cardiac death, cardiovascular disease in special population and specialised testing and therapeutics." (British Journal of Cardiology, 2011)Table of ContentsContributors, viii List of Abbreviations, xi Foreword, xv Section I Preventive Cardiology. Chapter 1 Prevention of Cardiovascular Disease, 3 Maulik Shah and Reza Ardehali Chapter 2 Dyslipidemia, 11 Karim Sallam and Reza Ardehali Chapter 3 Hypertension, 21 Christopher Woods and Richard Lafayette Section II Coronary Artery Disease. Chapter 4 Stable Angina, 35 Joshua Lehrer and William F. Fearon Chapter 5 Unstable Angina and Non-ST Elevation Myocardial Infarction, 43 Joshua Lehrer and David P. Lee Chapter 6 ST-Elevation Myocardial Infarction, 53 Yen Tibayan Section III Heart Failure. Chapter 7 Care of the Cardiomyopathic Patient, 69 Nicholas J. Leeper, Reza Ardehali, and Michael Fowler Chapter 8 Pulmonary Hypertension and Right Heart Failure, 81 Matthew T. Wheeler and Roham T. Zamanian Chapter 9 Heart Transplantation, 94 Jesus Almendral, Robert Maranda, and Sharon Hunt Section IV Valvular and Vascular Disease. Chapter 10 Valvular Heart Disease, 119 Reza Ardehali and Ingela Schnittger Chapter 11 Diseases of the Aorta, 139 Michael Ho and David Liang Chapter 12 Peripheral Vascular Disease, 154 Andrew Wilson, Reza Ardehali, and John Cooke Section V Arrhythmias and Sudden Cardiac Death. Chapter 13 Atrial Fibrillation and Flutter, 165 Marco Perez and Amin Al-Ahmad Chapter 14 Supraventricular Tachycardia, 177 Marco Perez and Paul Zei Chapter 15 Ventricular Tachycardia, 194 Jeffrey Hsing and Henry Hsia Chapter 16 Bradycardia, 204 Jeffrey Hsing and Paul Wang Chapter 17 Syncope, 212 Farheen Shirazi and Karen Friday Section VI Cardiovascular Disease in Special Populations. Chapter 18 Congenital Heart Disease, 227 Patrick Yue Chapter 19 Cardiology Consultation and Management of Perioperative Complications, 239 Azar Mehdizadeh and Stanley G. Rockson Chapter 20 Management of Pre- and Post-Cardiac Surgery Patients, 248 Mohammad Haghdoost and Ramin Beygui Section VII Specialized Testing and Therapeutics. Chapter 21 Adult Advanced Cardiac Life Support, 263 Anurag Gupta and Amin Al-Ahmad Chapter 22 ECG Interpretation, 272 Marco Perez and Victor F. Froelicher Chapter 23 Transthoracic and Transesophageal Echocardiography, 283 Shahriar Heidary and Ingela Schnittger Chapter 24 Noninvasive Stress Testing, 293 Arvindh Kanagasundram and Victor F. Froelicher Chapter 25 Cardiac MRI and CT, 303 Chandra Katikireddy and Michael V. McConnell Chapter 26 Clinical Cardiac Hemodynamics, 326 Shirley Park and Euan Ashley Chapter 27 Percutaneous Interventions, 340 Aiden O'Loughlin and Alan Yeung Chapter 28 Pacemakers and ICD Troubleshooting, 360 Marco Perez and Paul Wang Chapter 29 Introduction to Electrophysiology Studies, 370 Ronald Lo and Henry Hsia Index, 381
£57.95
Johns Hopkins University Press Speaking Honestly with Sick and Dying Children
Book SynopsisNiethammer's compelling personal experiences combined with the latest research make this a compassionate and invaluable resource for physicians, nurses, social workers, teachers, parents-for all who care for sick and dying children and adolescents.Trade ReviewA valuable and enlightening educational experience. Niethammer writes with authority and insight. -- Andrew R. Barnosky JAMATable of ContentsForeword, by Christoph Schmeling-KludasForeword, by Ruprecht NitschkePrefaceAcknowledgments1. Introduction2. Children, Sickness, and Death3. Children in the Hospital4. Children and Doctors5. Death and Dying in the Everyday Lives of Children6. Physician Paternalism versus Patient Autonomy7. The "Precociously Mature" Child8. Healthy Children's Concepts of Death9. Sick Children's Concepts of Death10. Should We Tell Sick Children the Truth?11. Decisions at the End of LifeReferencesName Index
£28.72
