Medicine / Healthcare: general issues / topics Books
John Wiley and Sons Ltd How to Facilitate Lifestyle Change
Book SynopsisGroup work and patient education are vital aspects of improving health outcomes in all settings, by supporting patients and clients to manage their conditions, as well as to promote and support behaviour change for improved health. Concise, accessible, and easy-to-read, this new title in the popular How To series is designed to support nutritionists, dietitians, nurses and other healthcare professionals to facilitate healthy lifestyle change through group education. How to Facilitate Lifestyle Change covers the entire group education process, from initial planning, to delivery and evaluation. Topics include agreeing aims and objectives and structuring a session, to considering practical aspects such as setting, managing challenging group members and participant expectations, as well as evaluating and refining a session plan for future use. It also provides an overview of the key evidence base for group learning, relevant theories and models, peer support, and e-Table of ContentsForeword viii Preface x Acknowledgements xii Chapter 1: Introduction 1 Amanda Avery 1.1 Overview 1 1.2 The need for lifestyle change 1 1.3 Why group education? 8 1.4 What is the evidence for group education? 10 References 17 Chapter 2: Behaviour change 21 Kirsten Whitehead 2.1 Introduction 21 2.2 What is behaviour change? 21 2.3 Why is behaviour change so important for lifestyle change? 22 2.4 Behaviour change theory and models 22 2.5 Behaviour change interventions 25 2.6 Behaviour change techniques 26 References 41 Further reading 42 Chapter 3: What makes a good facilitator? 43 Amanda Avery 3.1 The good facilitator 44 3.2 Communication skills for a group facilitator 46 3.3 How do effective groups form? 54 3.4 How do different people behave in groups? 57 3.5 And finally… 61 References 61 Chapter 4: Planning and organization 62 Kirsten Whitehead 4.1 Introduction 62 4.2 What are the priorities for group education? 63 4.3 Needs assessment 64 4.4 Subject areas for group education 64 4.5 Target participants 65 4.6 Recruitment 65 4.7 Preparing for a group education session 67 4.8 How to deliver a training session 74 References 80 Further reading 81 Chapter 5: Delivering the session 82 Vanessa Halliday 5.1 Introduction 82 5.2 Starting the session 82 5.3 Educational activities 87 5.4 Ending a session 107 References 108 Further reading 108 Useful websites 108 Chapter 6: Resources 109 Vanessa Halliday 6.1 Introduction 109 6.2 Resources for inclusive education 110 6.3 Practical considerations when selecting which resources to use 110 6.4 Types of resources 112 6.5 General considerations when using resources 115 6.6 Case studies 119 References 123 Useful websites 123 Chapter 7: Evaluation 125 Kirsten Whitehead 7.1 Introduction 125 7.2 What is evaluation? 125 7.3 Why evaluate? 126 7.4 What to evaluate? 126 7.5 Who should evaluate? 134 7.6 How to evaluate: tools and methods 134 References 148 Further reading 149 Useful websites 149 Chapter 8: Managing group interaction and how to overcome challenges 150 Vanessa Halliday 8.1 Introduction 150 8.2 Facilitating group interaction 150 8.3 Cultural sensitivity in group education 152 8.4 How to manage discussion of sensitive subjects 153 8.5 Avoiding challenging situations 154 8.6 Working with group members that exhibit behaviours that you find challenging to manage 154 8.7 Answering questions and maintaining your credibility when challenged 157 8.8 Managing the use of mobile devices 159 8.9 Timekeeping 160 8.10 Getting people to attend 161 8.11 Group dynamics 162 8.12 Working with co‐facilitators 163 References 165 Further reading 165 Chapter 9: Personal development in group facilitation skills 166 Amanda Avery 9.1 Introduction 166 9.2 Reflection 167 9.3 Peer observation 167 9.3 Additional training needs 172 References 174 Index 175
£999.99
John Wiley & Sons Inc An Introduction to Intermediate and Advanced
Book SynopsisNtoumanis and Myers have done sport and exercise science researchers and students a tremendous service in producing An Introduction to Intermediate and Advanced Statistical Analyses for Sport and Exercise Scientists.Table of ContentsAbout the editors xiii List of contributors xv Foreword xix Preface xxi 1 Factorial ANOVA and MANOVA 1 General Introduction 1 Hypothesis Testing 2 Alpha Level 2 Assumptions 3 Further Considerations 4 Utility in Sport and Exercise Sciences 6 Treatment Conditions 6 Existing Conditions 6 Individual Characteristics 7 Recent Usage 7 The Substantive Example 7 Univariate: Factorial ANOVA 8 Univariate Assumptions 8 The Synergy 10 Factorial ANOVA Analysis Plan 10 Example of a Write]Up Compatible with the APA Publication Manual 11 Factorial MANOVA Analysis Plan 13 Example of a Write]Up Compatible with the APA Publication Manual 13 Summary 16 Acknowledgment 18 References 18 2 Repeated measures ANOVA and MANOVA 19 General Introduction 19 Between] versus Within]Subjects Variables 19 Hypothesis Testing 20 Assumptions 20 Further Considerations 21 Utility in Sport and Exercise Sciences 22 Multiple Treatment Conditions 23 Multiple Assessments 23 Longitudinal Studies 23 Recent Usage 24 The Substantive Example 24 Univariate: Repeated Measures ANOVA 24 Univariate Assumptions 25 Multivariate: Repeated Measures MANOVA 26 Multivariate Assumptions 26 The Synergy 27 Repeated Measures ANOVA Analysis Plan 27 Example of a Write]Up Compatible with the APA Publication Manual 29 Repeated Measures MANOVA Analysis Plan 29 Example of a Write]Up Compatible with the APA Publication Manual 31 Summary 32 Acknowledgment 34 References 34 3 Mediation and moderation via regression analysis 35 General Introduction 35 Utility of the Methods in Sport and Exercise Science 36 The Substantive Example 38 Mediation 38 The Synergy 38 Mediation 38 The Substantive Example 44 Moderation 44 The Synergy 45 Moderation 45 Summary 53 References 55 4 Item response theory and its applications in Kinesiology 57 General Introduction 57 What Is IRT? 59 Other Commonly Used IRT Models 60 Assumptions Related to IRT 62 Unidimensionality 62 Local Independence 62 Addressing Model]Data Fit 62 Inspecting Model Assumptions 63 Inspecting Expected Model Features 63 Inspecting Overall Model]Data Fit 64 Computer Simulation for Model]Data Fit Testing 64 Unique Features and Advantages of IRT 65 Estimation Invariance 65 Common Metric Scale 65 Item and Test Information 66 Test Relative Efficiency 68 Global “Reliability” Is no Longer a Concern 69 Item Bank and IRT]Based Test Construction 69 Parameter Estimation and Software 71 Utility of the Methodology in Kinesiology 71 IRT Limitations and Future Direction 72 Conclusion 73 References 74 5 Introduction to factor analysis and structural equation modeling 79 General Introduction 79 Utility of the Method in Sport and Exercise Science 80 Terminology and Methodology 83 Evaluating Model Fit 86 Interpreting Parameter Estimates 88 The Substantive Example 89 The Synergy 91 EFA: Establishing the Factor Structure 91 CFA: Testing the Measurement Models 93 Structural Equation Modeling: Adding the Regression Paths 96 Summary 98 References 99 6 Invariance testing across samples and time: Cohort]sequence analysis of perceived body composition 101 General Introduction to the Importance of Measurement Invariance 102 Cohort]Sequential Designs: Longitudinal Invariance across Samples and Time 106 Substantive Application: Physical Self]Concept 107 Methodology 111 The PSDQ Instrument 111 Statistical Analyses 111 Goodness of Fit 112 Results 113 Basic Cohort]Sequence Model: Four Cohort Groups and Four Waves 113 Cohort]Sequence Design of Multiple Indicators, Multiple Causes Models 115 Use of Model Constraint with Orthogonal Polynomial Contrasts to Evaluate Cohort Sequence and MIMIC Latent Means 116 Use of Latent Growth Curve Models to Evaluate Stability/Change over Time 119 LGC Results 123 Summary, Implications, and Further Directions 123 Methodological Implications, Limitations, and Further Directions 123 References 125 7 Cross]lagged structural equation modeling and latent growth modeling 131 General Introduction 131 A Theoretical Framework for the Study of Change 132 Utility of the Method in Sport and Exercise Science 132 Analysis of Change 132 The Substantive Example 134 Theoretical Background 134 The Data: Participants and Measurement 134 The Synergy 135 CLPM 135 CLPM Example 137 Latent Growth Modeling 140 LGM Example 141 Model 2a: Unconditional LGM 143 Model 2b: Conditional LGM 145 Model 2c: Unconditional LGM with TVCs 145 Model 3: Parallel Process LGM 146 Model 4: Second]Order LGM 148 Summary 150 References 151 8 Exploratory structural equation modeling and Bayesian estimation 155 General Introduction 155 Utility of the Methods in Sport and Exercise Science 156 The Substantive Example(s) 159 The Motivational Correlates of Mentally Tough Behavior 159 Developing Synergies through Statistical Modeling 161 ESEM 161 Bayesian Estimation 168 Summary 179 References 180 9 A gentle introduction to mixture modeling using physical fitness performance data 183 General Introduction 183 Utility of the Method in Sport and Exercise Science 186 The Substantive Example(s) 187 Class Enumeration in Mixture Models 188 The Estimation of Mixture Models 190 The Synergy 190 LPA of Grade 5 Students and Tests of Invariance across Gender Groups 190 Inclusion of Covariates in LPA Solutions 195 LTA 196 Mixture Regression Analyses of Grade 5 Students 198 Latent Basis Growth Mixture Analyses: Cardiovascular Fitness 202 Piecewise Growth Mixture Analyses: Physical Strength 203 Summary 204 Acknowledgments 205 References 206 10 Multilevel (structural equation) modeling 211 General Introduction 211 Multilevel Structural Equation Modeling 212 Utility of the Methodology in Sport and Exercise Science 214 The Substantive Examples 215 Coaching Competency–Collective Efficacy–Team Performance: 1–1–2 216 Action Planning Intervention–Physical Activity Action Plans–Physical Activity: 2–1–1 217 The Synergy 218 Coaching Competency–Collective Efficacy–Team Performance: 1–1–2 219 Action Planning Intervention–Physical Activity Action Plans–Physical Activity: 2–1–1 222 Summary 229 References 230 11 Application of meta]analysis in sport and exercise science 233 General Introduction 233 Stages of Meta]Analysis 233 Key Elements of Meta]Analysis 234 Goals of Meta]Analysis 236 Utility of the Methodology in Sport and Exercise Science 238 The Substantive Example 238 The Synergy 241 Univariate Meta]Analysis 241 Multivariate Meta]Analysis 245 Summary 249 Acknowledgment 251 References 251 12 Reliability and stability of variables/instruments used in sport science and sport medicine 255 Introduction 255 A. Assessment of Test–Retest Agreement Using Interval/Ratio Data 256 A Worked Example Using the Test–Retest Differences of the Biceps Skinfold Measurements 257 B. Utility of the Assessment of Test–Retest Stability Using Categorical/Likert]Type Data 260 The Substantive Example 261 Utility of the Test–Retest Stability Using Nonparametric Data 261 The Synergy 262 Utility of the Item by Item Approach to Test–Retest Stability 263 The Synergy 263 Summary 265 References 266 13 Sample size determination and power estimation in structural equation modeling 267 General Introduction 267 Power 268 Power Analysis in SEM 268 Utility of the Methodology in Sport and Exercise Science 269 Power Analysis Regarding Model]Data Fit: An Introduction 269 Power Analysis Regarding Focal Parameters: An Introduction 270 The Substantive Example 272 Bifactor Model in Sport and Exercise Science 272 Bifactor Model and the PETES 273 The Synergy 275 Power Analysis Regarding Model]Data Fit: A Demonstration 276 Power Analysis Regarding Focal Parameters: A Demonstration 278 Summary 281 References 282 Index 285
£61.70
John Wiley and Sons Ltd Management of Complex Cardiovascular Problems
Book SynopsisPatients with complex cardiovascular problems pose a special management challenge for both the specialist and the non-specialist. This book helps you approach difficult cases with the confidence to strategically map care, understand the risk profile of your patient, and make effective treatment decisions. Dependable and succinct content provides high yield information for the busy cardiologist Take home call outs, and critical thinking boxes provide candid advice on incorporating guidelines and evidence based medicine into your practice New convenient pocket-sized format New chapter addressing cardiovascular problems in women Discussion of high risk factors for and strategic care mapping encourage clinical focus Clinical pearls offer expert advice on topical issues Includes emerging trends and clinical trials keeping you up to date Table of ContentsList of Contributors, vii Foreword to the Third Edition, xvii Preface, xix Acknowledgements, xxi 1 Hyperlipidemia, 1Vien T. Truong, Kim N. Huynh, Tam Ngo, Sara Shah, Hau Van Tran, Chisalu Nchekwube, Nabeel Ali and Faisal Latif 2 Hypertension, 30Udho Thadani and Nguyen Duc Cong 3 Stable Coronary Artery Disease, 50Mohammed Haris Umer Usman, Lê Hoàg Dúc Toàn, Lê Th.i Ngo. c Trâm, Huynh Th.i Thu Truc, An Huynh and Aman Amanullah 4 Acute Coronary Syndrome, 86Udho Thadani, Quang Tuan Nguyen and Han Yaling 5 ST Segment Elevation Myocardial Infarction, 113Thach Nguyen, Xu Bo, Faisal Latif, Ho Thuong Dung, Duane Pinto, Pham Manh Hung, Michael Gibson and Runlin Gao 6 Heart Failure (Stages A, B and C), 141Dan Le, Trong Ha Le, Vo˜ Minh Vîe. t, Bao V. Ho, Tuan D. Nguyen, Khalid Numan Al Azza, Hau Van Tran and Gianluca Rigatelli 7 Acute Decompensated and Chronic Stage D Heart Failure, 169Patrick Campbell, Selim R. Krim, Thach Nguyen, Marvin Eng, Yidong Wei and Hau Van Tran and Hector Ventura 8 Atrial Fibrillation, 198Mihail Gabriel Chelu, Ali Oto, Tuan D. Nguyen, Phan Dinh Phong, Tung Mai, Tom Bump and Rajasekhar Nekkanti 9 Ventricular Tachycardia, 233Sorin Lazar, Bao V. Ho, Phillip Tran, Pham Nhu Hung, Thomas Bump and Evgeny Shlyakhto 10 Syncope, 266Christopher M. Bianco, Rajasekhar Nekkanti, Faisal Latif, Phan Nam Hung, Phillip Tran, Hy Tat An and Thach Nguyen 11 Aortic Stenosis, 299Rajiv Goswami, Phillip Tran, Nguyen Lan Hieu, Aravinda Nanjundappa and Neal Kleiman 12 Mitral Regurgitation, 329Deepak Joshi, Rajasekhar Nekkanti, Marvin H. Eng, Madhur Roberts, Ngoc Quang Nguyen, Xian Kai Li and Michael Rinaldi 13 Cardiovascular Problems in Elderly Patients, 364Daniel E. Forman and Nanette Wenger 14 Cardiovascular Problems in Women, 379Kahroba Jahan, Ainol Shareha Sarar, Nisa Arshad, Nguyen Phuc Nguyen, Amsa Arshad, Sajaj Agarwal, Thach Nguyen and Kwan Lee Index, 406
£999.99
John Wiley and Sons Ltd Understanding Masticatory Function in Unilateral
Book SynopsisUnilateral posterior crossbite is a problem often seen in orthodontic practice, and properly understanding chewing patterns will lead to the most effective treatment program. Drawing on their research and available literature, Drs.Trade Review"I would highly recommend this book to postgraduate students, specialists in orthodontics, pedodontics, and stomatognathic physiology, and general dentists. It can be a great reference for anyone treating a young patient whose teeth may be developing in a questionable position." (AJO-DO May 2017)Table of ContentsForeword vii Preface viii How to Use This Book x Acknowledgments xi Chapter 1 Introductory Explanation of Masticatory Function 1 1.1 Introduction 2 1.2 The study of masticatory function 6 1.3 The evolution of electrognathography and electromyography 10 1.4 From the 1980s to today 23 1.5 Ready to start 24 References 26 Chapter 2 Physiology of Mastication: The Chewing Pattern and Masticatory Function 28 2.1 Introduction 29 2.2 Features of masticatory function 29 2.3 Terminology 34 2.4 The chewing pattern 37 2.5 The chewing pattern as an indicator of masticatory function 43 References 58 Chapter 3 Physiology of Mastication: Neuromuscular Control of Masticatory Function 61 3.1 Importance of the motor activity 62 3.2 The nervous system 65 3.3 Receptors in the stomatognathic system 69 3.4 Reflex movements 76 3.5 Automatic movements 77 3.6 Motor control: feedback and feed-forward 81 3.7 Neuromuscular control 83 3.8 Coordination of masticatory muscles during mastication 87 3.9 Neuromuscular adjustment to load 91 References 94 Chapter 4 Alterations to Masticatory Function in Unilateral Crossbites 98 4.1 Introduction 99 4.2 Crossbite=neuromuscular syndrome 100 4.3 Unilateral posterior crossbite 107 4.4 Alteration to masticatory function in unilateral posterior crossbite 112 4.5 Anterior crossbite=neuromuscular syndrome 136 References 141 Chapter 5 Therapy with Function Generating Bite Appliance: Actions and Effects on Malocclusion and Masticatory Function 144 5.1 Orthognathodontic therapy aimed to restore physiological neuromuscular equilibrium to the stomatognathic system 145 5.2 Dental–alveolar–basal actions and effects of function generating bite appliances 149 5.3 Therapy timing and duration and caries-free management 181 5.4 Compliance 182 References 182 Chapter 6 Cases 185 6.1 Introduction 186 6.2 Case 1: Right unilateral posterior crossbite (3 years, 9 months) 186 6.3 Case 2: Right unilateral posterior crossbite (6 years, 4 months) 189 6.4 Case 3: Positional crossbite (7 years, 6 months) 193 6.5 Case 4: Left unilateral posterior crossbite (7 years, 11 months) 200 6.6 Case 5: Right unilateral posterior crossbite (10 years, 3 months) 205 6.7 Case 6: Anterior open bite and left unilateral posterior crossbite (7 years, 9 months) 209 6.8 Case 7: Anterior open bite and bilateral posterior crossbite (7 years, 8 months) 215 References 215 Appendix 225 Index 227
£117.85
John Wiley & Sons Inc Walking the Weight Off For Dummies
Book SynopsisGet up, get moving, and walk away the pounds If you're looking to lose weight and get fit, Walking the Weight Off For Dummies will show you just what to do to walk yourself to a whole new you.Table of ContentsIntroduction 1 Part I: Getting Started with Walking 5 Chapter 1: The Perfect Exercise: Walking 7 Chapter 2: The Health Benefits of Walking 27 Chapter 3: How Walking Sheds Pounds 47 Part II: Preparing and Fueling Your Body 61 Chapter 4: Hitting the Road 63 Chapter 5: Walking Workout Equipment and Preparation 79 Chapter 6: The Science of Walking 93 Chapter 7: Fueling Your Walking Workout 111 Chapter 8: Delicious and Healthy Recipes 127 Part III: Walking Workouts 145 Chapter 9: Creating the Best Walking Routine for You 147 Chapter 10: Walking Routines 157 Chapter 11: Taking Your Workout to the Next Level 191 Part IV: Walking Considerations for Any Condition 203 Chapter 12: Walking to Improve Diabetes 205 Chapter 13: Walking Away Heart Disease 217 Chapter 14: Walking Your Belly and Butt Off 227 Chapter 15: Walking During Pregnancy and Beyond 233 Chapter 16: Walking with Arthritis and Osteoporosis 253 Chapter 17: Overcoming Obstacles 267 Chapter 18: Maintaining Your Weight Loss 281 Part V: The Part of Tens 295 Chapter 19: Ten Ways to Maximize Your Walking Workout 297 Chapter 20: Ten Essential Tools for Any Walker 303 Index 309
£16.19
John Wiley & Sons Inc Toward a 21st Century Health System
Book SynopsisToward a 21st Century Health System is a collection of thoughtful analyses that explore a key element of the health care delivery system-physician group practices. Edited by policy experts Alain Enthoven and Laura Tollen, and written by a blue ribbon panel of health policy scholars and leaders including Stephen Shortell, Hal Luft, Donald Berwick, James Robinson, and Helen Darling, this resource addresses a variety of topics, including Organized delivery systems Quality of care in prepaid group practice versus other types of managed care The role of physician leadership and culture in group practice Prepaid group practice and the formation of national health policy This comprehensive resource also covers such topics as pharmacy benefit management, technology assessment, health services research, and employer purchasing of benefits all as they relate to prepaid group practice.Table of ContentsTables and Exhibits ix Acknowledgments xi The Contributors xiii Foreword xxiiiWilliam L. Roper Preface xxviiAlain C. Enthoven, Laura A. Tollen 1 Prepaid Groups and Organized Delivery Systems: Promise, Performance, and Potential 1Stephen M. Shortell and Julie Schmittdiel 2 Systems and Results: The Basis for Quality Care in Prepaid Group Practice 22Donald M. Berwick and Sachin H. Jain 3 The Clinical and Economic Performance of Prepaid Group Practice 45Kenneth H. Chuang, Harold S. Luft, and R. Adams Dudley 4 Prepaid Group Practice and Health Care Policy 61Jon B. Christianson and George Avery 5 Technology Assessment, Deployment, and Implementation in Prepaid Group Practice 85David M. Eddy 6 Managing the Pharmacy Benefit in Prepaid Group Practice 108William H. Campbell, Richard E. Johnson, and Sharon L. Levine 7 Prepaid Group Practice and Medical Workforce Policy 128Jonathan P. Weiner 8 Prepaid Group Practice and Health Care Research 156Raymond Fink and Merwyn R. Greenlick 9 Physician Leadership: “Group Responsibility” as Key to Accountability in Medicine 179Francis J. Crosson, Allan J. Weiland, and Robert A. Berenson 10 The Limits of Prepaid Group Practice 199James C. Robinson 11 The Relationship Between Prepaid Group Practice and the Employer Community 213Helen Darling 12 Open the Markets and Level the Playing Field 227Alain C. Enthoven Editors’ Introduction to the Epilogue 247 Epilogue: Prepaid Group Practice and Computerized Caregiver Support Tools 249George C. Halvorson Appendix: The Origins of Prepaid Group Practice in the United States 265Jon A. Stewart Index 275
£41.75
John Wiley & Sons Inc Paleo AllinOne For Dummies
Book SynopsisLive the Paleo lifestyle to get healthy and fit with natural foods Paleo All-In-One For Dummies is the powerhouse resource that includes all the information you''ll need to get started with the Paleo lifestyle or further refine your diet if you''re already a convert! With content from leading authorities on the Paleo lifestyle, this easy-to-read, all-in-one resource offers a complete overview of living the primal life to lose weight, improve athletic performance, get fit, and stay healthy. Use the tips from the book to change your diet to include healthy, natural foods, then jump into the companion workout videos to master the Paleo moves and techniques that are featured in the book. The Paleo movement is taking the scientific world by storm, with studies indicating that the diet lowers the risk of cardiovascular disease, encourages weight loss, controls acne, and leads to greater overall health and athletic performance. Discover an appealing, sustTable of ContentsIntroduction 1 Book I: Getting Started with Paleo 5 Chapter 1: Grasping the What and Why of Paleo 7 Chapter 2: Modern Foods and Your Inner Cave Man 33 Chapter 3: Preparing and Using Your Cave Kitchen 63 Chapter 4: Using Paleo Concepts in Your Fitness Routine 89 Chapter 5: Making Paleo Practical in a Modern World 113 Book II: Recipes for Every Occasion and Meal 137 Chapter 1: Crafting Paleo Breakfasts 139 Chapter 2: Packing Nutrition into Soups and Salads 157 Chapter 3: The Meat (and More) of the Matter: Paleo Main Dishes 189 Chapter 4: Paleo Life in the Slow (Cooker) Lane 209 Chapter 5: Vegetable Dishes That Satisfy 227 Chapter 6: Paleo for Kids: Recipes Your Littles Will Love 245 Book III: Paleo Extras: Snacks, Sauces, Spice Mixes, and Sweets 257 Chapter 1: Snacks That Fuel Your Body, Sugar Crash Not Included 259 Chapter 2: Spicing Up Paleo Cooking with Sauces, Dressings, and Salsas 275 Chapter 3: Mixing Rubs and Paleo Seasonings 295 Chapter 4: Satisfying Your Sweet Tooth 307 Book IV: Primal Power Moves for a Healthier Body 335 Chapter 1: Hinging and Squatting Your Butt and Legs to Primal Perfection 337 Chapter 2: Pushes and Pulls for a Strong, Solid Torso 363 Chapter 3: Carrying Heavy Things and Ab Exercises That Don’t Suck 387 Chapter 4: Primal Power Moves for Explosive Athleticism 411 Chapter 5: Beyond Strength Training and Cardio to Metabolic Conditioning 425 Chapter 6: Programs for Getting Started — and for Pushing Forward 447 Appendix 481 Index 485
£18.69
John Wiley & Sons Inc Paleo Desserts For Dummies
Book SynopsisMore than 125 simple and sweet recipes for Paleo-friendly desserts Following a Paleo Diet doesn't mean you have to give up your favorite desserts and treats. Paleo Desserts For Dummies offers up more than 125 tasty and delectable dessert recipes that you can enjoy while staying true to the Paleo lifestyle.Table of ContentsIntroduction 1 Part I: Reaping the Benefits of Paleo Desserts 5 Chapter 1: What is Paleo? 7 Chapter 2: The Paleo Kitchen Makeover 23 Chapter 3: The Nuts and Bolts of Paleo Dessert]Making 39 Part II: Guilt]Free Paleo Desserts — Time to Get in the Kitchen 59 Chapter 4: Brownies, Bars, and Fudge 61 Chapter 5: Classic Breads 83 Chapter 6: Cakes and Pies 93 Chapter 7: Decadent Chocolates and Truffles 121 Chapter 8: Cookies 143 Chapter 9: Ice Cream and Frozen Treats 169 Chapter 10: Muffins and Cupcakes 191 Chapter 11: Sauces, Fruit Spreads, and Nut Butters 215 Part III: Sweet Holiday Paleo Desserts 225 Chapter 12: Paleo Halloween 227 Chapter 13: Paleo Thanksgiving 233 Chapter 14: Paleo Christmas and Hanukkah 243 Part IV: Part of Tens 253 Chapter 15: Ten Tips for Making Paleo Desserts 255 Chapter 16: Ten Nutritious Paleo Food Substitutions 261 Index 267
£15.29
John Wiley and Sons Ltd Injectable Fillers
Book SynopsisIn the innovative field of cosmetic dermatology, the range of products and methods available to patients is expanding all the time. Prominent among these are facial fillers, which, when injected into and beneath the skin, help alleviate wrinkles and improve smoothness. However, the many fillers on offer have varying characteristics and effects, and practitioners must be properly trained in order to administer them safely and successfully. Injectable Fillers offers those performing these popular procedures an in-depth and far-reaching survey of current best practices, with a strong emphasis on safety. Covering everything from the science behind facial fillers to their appropriate means of application, the book places each product in context, demonstrating the pros and cons of the expanding range of hyaluronic acids and calcium hydroxylapatite microspheres, and exploring injectable submental fat reduction with sodium deoxycholate. This second edition broadens the scope Table of ContentsList of Contributors vii Foreword ix About the Companion Website xi 1 Injection Anatomy: Avoiding the Disastrous Complication 1Arthur Swift, Claudio DeLorenzi, and Krishnan M. Kapoor 2 The Mathematics of Facial Beauty 29Arthur Swift and B. Kent Remington 3 The Temple and Forehead 63Tatjana Pavicic, Ardalan Minokadeh and Sebastian Cotofana 4 The Eyebrow Revisited 77B. Kent Remington and Arthur Swift 5 Periorbital Rejuvenation 93Arthur Swift and Herve Raspaldo 6 The Midface and Cheeks 119Jeanette M. Black, Ardalan Minokadeh and Derek H. Jones 7 Injection Rhinoplasty – Aesthetic Considerations and the Anatomical Basis for Safe Injection Techniques 131Woffles T.L. Wu 8 The Lips 149Shannon Humphrey 9 The Mandible, Jawline, and Chin 165Amir Moradi and Jeff Watson 10 Submental Contouring 175Frederick C. Beddingfield III, Jeanette M. Black, Paul F. Lizzul, and Ardalan Minokadeh 11 Avoidance and Management of Complications 191Katie Beleznay and Derek H. Jones Index 207
£92.66
John Wiley & Sons Inc Reinventing Public Health
Book SynopsisReinventing Public Health offers guidance for translating the growing body of research on the fundamental social, economic, and ecological determinants of health into innovative programs and policies to improve the health of populations.Table of ContentsFigures, Tables, and Exhibits vii Foreword xi Preface xv Acknowledgments xix The Editor xxiii The Contributors xxv 1 Analytic Framework 1Lu Ann Aday 2 Fundamental Determinants of Population Health 35Kathryn M. Cardarelli, Janet S. de Moor, M. David Low, Barbara J. Low 3 Sustainable Development 65Sondip K. Mathur, Carl S. Hacker, Lu Ann Aday 4 Human Development 106Barbara J. Low, M. David Low, Kathryn M. Cardarelli, Janet S. de Moor 5 Economic Development 183Luisa Franzini, J. Michael Swint, Yuki Murakami, Rafia S. Rasu 6 Community Development and Public Health 237Cynthia Warrick, Dan Culica, Beth E. Quill, William D. Spears, Rachel Westheimer Vojvodic 7 Toward a Healthy (Re)Public 285Lu Ann Aday, Beth E. Quill, Hardy D. Loe Jr., Charles E. Begley Name Index 333 Subject Index 000
£62.65
John Wiley and Sons Ltd Inflammatory Bowel Diseases
Book SynopsisInflammatory Bowel Diseases: A Clinician s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases.Trade Review“This is a valuable book that everybody taking care of IBD patients should have. It is very concise but at the same time very complete” Henrique Fernandez, MD, FACP, Parkview Medical Center on behalf of Doody’sTable of ContentsPreface ix Section I Pathogenesis and Clinical Features 1 1 Epidemiology and Pathogenesis 3 Clinical Take Home Messages 3 Epidemiology 3 Pathogenesis 6 Genetics 6 Microbiome 8 Environmental Triggers 9 Case Studies and Multiple Choice Questions 12 References 13 Answers to Questions 15 2 Clinical Features and Diagnosis of Crohn’s Disease 17 Clinical Take Home Messages 17 Clinical Features 19 Disease Course and Natural History 20 Diagnosis 21 History and Physical Examination 21 Laboratory Investigations 22 Serologic Markers 23 Endoscopy 23 Histology 25 Imaging Studies 25 Case Studies and Multiple Choice Questions 27 References 28 Answers to Questions 31 3 Clinical Features and Diagnosis of Ulcerative Colitis 33 Clinical Take Home Messages 33 Clinical Features 34 Disease Course and Natural History 35 Diagnosis 35 History and Physical Examination 36 Laboratory Investigations 36 Serologic Markers 37 Endoscopy 37 Histology 39 Imaging Studies 40 Differential Diagnosis (UC and CD) 40 Case Studies and Multiple Choice Questions 44 References 45 Answers to Questions 47 4 Extraintestinal Manifestations of Inflammatory Bowel Diseases 49 Clinical Take Home Messages 49 Arthritis and Arthropathy 50 Metabolic Bone Disease 51 Cutaneous Manifestations 52 Hepatobiliary Manifestations 53 Ophthalmologic Manifestations 55 Renal Complications 55 Thromboembolic and Cardiovascular Complications 56 Case Studies and Multiple Choice Questions 57 References 58 Answers to Questions 61 Section II Therapeutic Agents 63 5 Aminosalicylates 65 Clinical Take Home Messages 65 Efficacy in Ulcerative Colitis 66 Efficacy in Crohn’s Disease 68 Safety 68 Multiple Choice Questions 70 References 71 Answers to Questions 73 6 Corticosteroids 75 Clinical Take Home Messages 75 Efficacy in Ulcerative Colitis 76 Efficacy in Crohn’s Disease 77 Safety 78 Case Studies and Multiple Choice Questions 80 References 81 Answers to Questions 83 7 Immunomodulators 85 Clinical Take Home Messages 85 Thiopurines 85 Efficacy in Ulcerative Colitis 87 Efficacy in Crohn’s Disease 88 Safety 89 Methotrexate 90 Efficacy in Ulcerative Colitis 90 Efficacy in Crohn’s Disease 91 Safety 91 Calcineurin Inhibitors 91 Efficacy in Ulcerative Colitis 91 Efficacy in Crohn’s Disease 93 Case Studies and Multiple Choice Questions 94 References 95 Answers to Questions 99 8 Biologic Therapies 101 Clinical Take Home Messages 101 Infliximab 102 Efficacy in Ulcerative Colitis 102 Efficacy in Crohn’s Disease 105 Safety 108 Adalimumab 110 Efficacy in Ulcerative Colitis 110 Efficacy in Crohn’s Disease 111 Certolizumab Pegol 112 Efficacy in Crohn’s Disease 113 Newer Therapies 115 Case Studies and Multiple Choice Questions 116 References 117 Answers to Questions 121 9 Antibiotics 123 Clinical Take Home Messages 123 Efficacy in Ulcerative Colitis 123 Efficacy in Crohn’s Disease 124 Other Microbial Modification Methods – Probiotics and Fecal Microbiota Transplantation 125 Multiple Choice Questions 126 References 127 Answers to Questions 129 Section III Management 131 10 Medical Management of Ulcerative Colitis 133 Clinical Take Home Messages 133 Assessment of Extent, Activity, and Severity 133 Limited Colitis – Proctitis, Proctosigmoiditis, and Left‐sided Colitis 135 Pancolitis 136 Mild to Moderate Disease 137 Moderate to Severe Disease 138 Severe Disease 140 Case Studies and Multiple Choice Questions 142 References 144 Answers to Questions 146 11 Medical Management of Crohn’s Disease 149 Clinical Take Home Messages 149 Mild to Moderate Disease 150 Moderate to Severe Disease 151 Case Studies and Multiple Choice Questions 154 References 156 Answers to Questions 157 12 Surgical Management of Inflammatory Bowel Diseases 159 Clinical Take Home Messages 159 Surgery for Ulcerative Colitis 159 Pouch‐related Complications in Ulcerative Colitis 161 Surgery for Crohn’s Disease 163 Prophylaxis for Prevention of Postoperative Recurrence in Crohn’s Disease 164 Case Studies and Multiple Choice Questions 167 References 168 Recommended Reading 169 Answers to Questions 170 13 Complications of Inflammatory Bowel Diseases 171 Clinical Take Home Messages 171 Complications of Ulcerative Colitis 172 Toxic Megacolon and Perforation 172 Colonic Strictures 173 Clostridium difficile and Cytomegalovirus Colitis 173 Colorectal Dysplasia and Cancer 174 Magnitude and Risk Factors 174 Surveillance for Dysplasia and Cancer 175 Management of Dysplasia 175 Chemoprevention 176 Complications of Crohn’s Disease 176 Fibrostenosis and Strictures 176 Abscesses 177 Fistulizing Crohn’s Disease 178 Small‐bowel Cancer 181 Case Studies and Multiple Choice Questions 182 References 184 Answers to Questions 187 Section IV Special Considerations 189 14 Nutrition in Inflammatory Bowel Diseases 191 Clinical Take Home Messages 191 Malnutrition and Micronutrient Deficiencies 191 Dietary Therapies for Inflammatory Bowel Diseases 193 Case Studies and Multiple Choice Questions 194 References 195 Answers to Questions 197 15 Pregnancy, Conception, and Childbirth 199 Clinical Take Home Messages 199 Fertility 199 Effect of Pregnancy on Disease 200 Effect of Disease on Pregnancy 200 Maternal Medication Use During Pregnancy 201 Paternal Medication Use 203 Inheritance 203 Case Studies and Multiple Choice Questions 204 References 205 Answers to Questions 207 16 Inflammatory Bowel Disease During Childhood and Adolescence 209 Clinical Take Home Messages 209 Epidemiology and Clinical Features 209 Treatment of Pediatric Inflammatory Bowel Disease 210 Very Early‐onset Inflammatory Bowel Disease 211 Transition of Care in Pediatric Crohn’s Disease 211 Case Studies and Multiple Choice Questions 213 References 214 Answers to Questions 216 Index 217
£87.26
John Wiley and Sons Ltd The CSA Exam
Book SynopsisFirst Prize in Primary health carein the 2017 BMA Medical Book Awards Written by a team of practising GPs and CSA examiners, in collaboration with the recent CSA Role-Player Lead responsible for training and quality-assuring the work of the simulated patients in the exam, The CSA Exam: Maximizing your Success is a key resource for trainees and their trainers, in preparing for this component of the MRCGP assessment. Designed to help readers prepare and master the knowledge, skills, and attitudes needed to pass, it focuses on what is truly expected by examiners and demystifies all aspects of the exam.Giving insight into how candidates and trainers can maximize their potential, The CSA Exam: Maximizing your Success includes:Essential Learning Points, and Hints and Tips on Getting Started', The Consultation' and On the Day'Advice on applying an ethical approach to consultations and dealing with possible areas of concernA variety of Table of ContentsAbout the companion website vii About the authors ix Acknowledgements xi Foreword xiii PART ONE Introduction 3 Chapter 1 Maximizing your potential in the CSA 5 Chapter 2 What you can learn from the ‘patients’ 16 Chapter 3 What to expect in the CSA 28 Chapter 4 Dealing with challenging situations 48 Chapter 5 Creating and role-playing your own CSA-type case 59 Chapter 6 Maximizing your potential with feedback from examiners 65 Chapter 7 Strategies for candidate concerns with the CSA 80 Chapter 8 Learning points 88 PART TWO A ‘PALETTE‘ OF 16 CSA-TYPE CASES AND 6 ETHICAL CASES Introduction to the sample cases 101 Case 1 Alan Arterton 105 Case 2 Jane Smith re Isabel Chalk 113 Case 3 Jason Brown 120 Case 4 Ian Marsden 127 Case 5 Gavin South 135 Case 6 Louise Bradley 142 Case 7 Jenny Stanley 149 Case 8 Harry Evans 156 Case 9 Shona Baker 163 Case 10 Amelia Kowalski 170 Case 11 Thomas Smith 177 Case 12 Debbie Wells 184 Case 13 Ashia Pollock 191 Case 14 Olu Wa-Simba 198 Case 15 Nilesh Patel 205 Case 16 Stephanie Caldwell 212 Index 219
£36.96
John Wiley and Sons Ltd Digital Planning and Custom Orthodontic Treatment
Book SynopsisDigital Planning and Custom Orthodontic Treatment offers a thorough overview of digital treatment planning as it relates to custom orthodontic treatment.Table of ContentsList of Contributors vii Preface xi Acknowledgments xv 1 Documentation of the Dentition 1K. Hero Breuning 2 Documentation of the Face 9K. Hero Breuning 3 DynamicMotion Capture of the Mandible 15Shushu He and Chung H. Kau 4 Analysis of Digital Dental Documentation 27K. Hero Breuning and Chung H. Kau 5 Orthodontic Treatment Planning 31K. Hero Breuning and Chung H. Kau 6 CustomAppliance Design 41K. Hero Breuning 7 CustomAppliance Fabrication and Transfer 47K. Hero Breuning 8 Monitoring of Tooth Movement 55Philippe Salah and K. Hero Breuning 9 CustomRetention after Orthodontic Treatment 65K. Hero Breuning 10 The Invisalign System 69Orhan Tuncay 11 Custom Lingual Appliances 81Neil Warshawsky, Thomas W. Örtendahl, Chung H. Kau and K. Hero Breuning Appendix 115 Index 117
£93.57
John Wiley and Sons Ltd How to Teach Using Simulation in Healthcare
Book SynopsisHow to Teach Using Simulation in Healthcare provides an ideal introduction and easy-to-use guide to simulation in medical education.Trade Review"It utilises an undeniable wealth of knowledge from the authors, leading to a book which is well written and informative, covering a diverse range of subjects" – Journal of Perioperative PracticeTable of ContentsList of Figures vii List of Tables ix About the Authors xi Preface xv Chapter 1: Introduction 1 Chapter 2: Simulation‐based medical education (SBME): some specifics 3 Chapter 3: Simulation in (medical) education: some background 13 Chapter 4: Equipment in SBME: more than just a mannikin? 27 Chapter 5: Physical and psychological realism 37 Chapter 6: Simulation mapping and scenario design 45 Chapter 7: Running a simulation session: some practicalities 55 Chapter 8: Formative assessment and feedback 65 Chapter 9: Summative assessment 73 Chapter 10: Human factors, ergonomics and non‐technical skills 83 Chapter 11: Five case examples 97 Chapter 12: Using new technology to enhance learning 119 Chapter 13: Commissioning a simulation centre 139 Chapter 14: Training for simulation faculty 151 Chapter 15: Conclusions and next steps 157 Chapter 16: Annotated bibliography 159 Index 163
£35.10
John Wiley and Sons Ltd Clinical Cases in Dental Hygiene
Book SynopsisClinical Cases in Dental Hygiene is an indispensable resource to understanding both the theory and practice of dental hygiene, illustrated by real-life cases in a clinically relevant format. Offers a unique case-based format that supports problem-based learningPromotes independent learning through self-assessment and critical thinkingIncludes a wealth of relevant cases for understanding dental procedures and management of patientsCovers all essential topics within the scope of dental hygieneTable of ContentsList of Contributors . xi Preface xv Chapter 1 Patient Examination 1 Case 1 Examination and Documentation 2 Stefania Moglia Willis Case 2 Head and Neck Examination 9Stefania Moglia Willis Case 3 Radiographic Exam 15Aaron E. Yancoskie Case 4 Occlusal Examination 21Stefania Moglia Willis Case 5 Gingival Examination 29Aaron E. Yancoskie Case 6 Periodontal Exam 36Aaron E. Yancoskie Chapter 2 Dental Hygiene Diagnosis 43 Case 1 Plaque‐Induced Gingivitis 44Holly S. Harper Case 2 Non‐Plaque‐Induced Gingivitis 49Holly S. Harper Case 3 Drug‐Induced Gingivitis 54Holly S. Harper Case 4 Chronic Periodontitis 60Holly S. Harper Case 5 Aggressive Periodontics 65Holly S. Harper Case 6 Local Contributing Factors 70Holly S. Harper Chapter 3 Planning and Managing Dental Hygiene Care 75 Case 1 Infection Control 76Shirley S. Birenz and Cynthia J. Howard Case 2 Emergency Situations and Provision of Appropriate Care 82Shirley S. Birenz and Cynthia J. Howard Case 3 Individualized Patient Care 88Shirley S. Birenz and Cynthia J. Howard Case 4 Nutritional Counseling 94Shirley S. Birenz and Cynthia J. Howard Case 5 Dental Hygiene Treatment Strategies 101Shirley S. Birenz and Cynthia J. Howard Chapter 4 Nonsurgical Periodontal Procedures 109Case 1 Periodontal Debridement (Hand, Ultrasonic, Sonic Instrumentation) 110Judith Kreismann and Marija L. CahoonCase 2 Reassessment and Maintenance 116Judith Kreismann and Marija L. Cahoon Case 3 Oral Hygiene Instruction with Limited Dexterity 122Judith Kreismann and Marija L. Cahoon Chapter 5 Pharmacology 127 Case 1 Pain and Anxiety Control: Analgesics 128Ronald J. Lehane Case 2 Pain and Anxiety Control: Topical and Local Anesthetics 133Ronald J. Lehane Case 3 Pain and Anxiety Control: Nitrous Oxide 138Ronald J. Lehane Case 4 Topical Drug Delivery (Local Drug Delivery, Oral Rinses, and Irrigation) 143Ronald J. Lehane Case 5 Systemic Antibiotics and Enzyme Suppression Therapy 149Ronald J. Lehane Chapter 6 Surgical Periodontal Procedures 155 Case 1 Surgical Support Services 156Edgard S. El Chaar and Stephanie E. Cruz Case 2 Implant Procedures and Maintenance 161Edgard S. El Chaar and Stephanie E. Cruz Chapter 7 Preventive Therapies 167 Case 1 Plaque Removal; Individualized Patient Education 168Kellie R. Kennedy Case 2 Fluoride – Systemic and Topical 176Mark S. Wolff Case 3 Pit and Fissure Sealants 180Mark S. Wolff Chapter 8 Introduction to Biomaterials 187 Case 1 Biomaterials: Dental Implants and Peri‐implantitis 189Lorilei Kirby Case 2 Polishing Restored and Natural Teeth 194Lorilei Kirby Case 3 Alginate Impressions 200Lorilei Kirby Case 4 Dentinal Hypersensitivity 207Kim Attanasi Chapter 9 Management of Special Needs Patients 213 Case 1 Older Adult 214Rosemary D. Hays, Eva M. Lupovici, and Sarah Yoon Kang Case 2 Psychiatric Disability 220Rosemary D. Hays, Eva M. Lupovici, and Sarah Yoon Kang Case 3 Abuse 224Rosemary D. Hays, Eva M. Lupovici, and Sarah Yoon Kang Case 4 Substance‐Related Disorder 231Rosemary D. Hays, Eva M. Lupovici, and Sarah Yoon Kang Chapter 10 Management of Medically Complex Patients 237 Case 1 Patient with Diabetes 238Debra Ferraiolo Case 2 Patient with Asthma 244Miriam R. Robbins Case 3 Patient with Hypertension 248Silvia Spivakovsky Case 4 Patient Taking Antithrombotic Drugs – Valve Replacement 252Analia Veitz‐Keenan Case 5 Patient with Kidney Disease 258Joan A. Phelan Chapter 11 Professional Responsibility 263 Case 1 Ethical Principles – Informed Consent 264Winnie Furnari Case 2 Regulatory Compliance 271Winnie Furnari Case 3 Patient and Professional Communication 276Winnie Furnari Chapter 12 Community and Oral Health Promotion 283 Case 1 Participating in Community Programs 284Lisa B. Stefanou and Dianne L. Sefo Case 2 Promoting Health and Preventing Disease within Groups 290Lisa B. Stefanou and Dianne L. Sefo Index 297
£71.96
John Wiley & Sons Inc Alzheimers Dementia For Dummies
Book SynopsisYour sensitive, authoritative guide to Alzheimer's and dementia If a loved one has recently been diagnosed with dementia or Alzheimer's disease, it's only natural to feel fraught with fear and uncertainty about what lies ahead. Fortunately, you don't have to do it alone.Table of ContentsIntroduction 1 Part 1: Getting Started with Alzheimer’s and Dementia 5 Chapter 1: An Overview of Dementia and Alzheimer’s Disease 7 Chapter 2: Spotting the Symptoms 17 Chapter 3: Considering Causes and Risk Factors 39 Chapter 4: Distinguishing Dementia and Alzheimer’s Disease from Other Medical Conditions 61 Part 2: Helping a Loved One Manage the Illness 71 Chapter 5: Receiving a Diagnosis 73 Chapter 6: Looking at the Tests Used to Diagnose Alzheimer’s Disease 95 Chapter 7: Understanding the Stages of Dementia and Alzheimer’s Disease 111 Chapter 8: Eyeing Medical Treatments 125 Chapter 9: Considering Nonmedical Treatments 139 Part 3: Providing Care for Your Loved One 163 Chapter 10: Managing Your Loved One’s Care and Day-to-Day Life 165 Chapter 11: Making Medical Decisions 205 Chapter 12: Addressing Legal Issues 217 Chapter 13: Working through Financial Issues on Behalf of Your Loved One 243 Chapter 14: Choosing Ongoing Care for Your Loved One 265 Chapter 15: Easing the Transition to New Surroundings 295 Part 4: Respite Care for the Caregiver 307 Chapter 16: Coping While Caregiving 309 Chapter 17: Finding Support 339 Chapter 18: Knowing What to Do If the Person with Dementia Goes into the Hospital 349 Chapter 19: Keeping Up with Work and Family as a Caregiver 355 Chapter 20: Helping When You’re Not the Primary Caregiver 367 Part 5: The Part of Tens 377 Chapter 21: Ten Tips for Dealing with Dementia 379 Chapter 22: Ten Tips for Caregivers, Friends, and Families 387 Chapter 23: Busting Ten Myths about Dementia and Alzheimer’s Disease 395 Appendix: Resources for Caregivers 401 Index 407
£18.69
John Wiley and Sons Ltd The Electrocardiogram in Emergency and Acute Care
Book SynopsisThe Electrocardiogram in Emergency and Acute Care Clear, practical guidance in mastering ECG interpretation in the critically ill patient The Electrocardiogram in Emergency and Acute Care contains clear, practical guidance on mastering both single-lead and 12 lead ECGs, covering the full range of complexities and including a section on differential diagnosis of more common ECGs, with over 200 tracings from which to learn and self-test. The editors place an emphasis on readability and accessibility, with clearly written chapters and excellent illustrations that serve as a primary source of information for students, trainees, and practicing emergency physicians in all areas. In The Electrocardiogram in Emergency and Acute Care, readers can expect to find detailed information on topics such as: Clinical applications, impact, and interpretation of the electrocardiogram, plus variants of the normal, lead misplacement, and electrocardiographic artifact encountered in clinical practiceCardiacTable of ContentsEditors and Contributors x Foreword xii Preface xiv Section I The ECG in Clinical Care 1 1 Clinical Applications of the Electrocardiogram 3 George Glass x 2 Clinical Impact of the Electrocardiogram (ECG) 10 Robert C. Schutt, William J. Brady, Korin B. Hudson, and Steven H. Mitchell 3 Interpretation of the Electrocardiogram – Single- , Multi- , and 12- Lead Analysis 15 Robert C. Reiser, Robert C. Schutt, Korin B. Hudson, and William J. Brady 4 Variants of the Normal, Lead Misplacement, and Electrocardiographic Artifact Encountered in Clinical Practice 21 Robert C. Reiser, Robert C. Schutt, Korin B. Hudson, and William J. Brady Section II Cardiac Rhythms and Cardiac Dysrhythmias 27 5 Cardiac Rhythms with Normal Rates 29 Korin B. Hudson and William J. Brady 6 Narrow QRS Complex Tachycardia 33 Courtney B. Saunders and Jeffrey D. Ferguson 7 Wide QRS Complex Tachycardia 41 Michael Levy and Francis X. Nolan, Jr † 8 Bradycardia 48 Korin B. Hudson, J. Aidan Boswick, and William J. Brady 9 Atrioventricular Conduction Block 54 Steven H. Mitchell, Korin B. Hudson, and William J. Brady 10 Intraventricular Conduction Block: Bundle Branch Block and Other Conduction Abnormalities 59Steven H. Mitchell, Richard B. Utarnachitt, and William J. Brady 11 Atrial and Ventricular Ectopic Beats 67 Jeffrey D. Ferguson, Michael Levy, J. Aidan Boswick, and William J. Brady Section III Acute Coronary Syndrome and the 12- Lead ECG 73 12 Ischemic Heart Disease: Anatomic and Physiologic Considerations 75 Peter Pollak, Peter Monteleone, Kelly Williamson, David Carlberg, and William J. Brady 13 Electrocardiographic Findings in Acute Coronary Syndrome 82 Peter Monteleone, Peter Pollak, David Carlberg, and William J. Brady Section IV Special Populations, High- Risk Presentation Scenarios, and Advanced Electrocardiographic Techniques 101 14 The Electrocardiogram in the Pediatric Patient 103 Robert Rutherford, Robin Naples, and William J. Brady 15 The Electrocardiogram in the Poisoned Patient 111 Steven H. Mitchell, Christopher P. Holstege, and William J. Brady 16 The Electrocardiogram in Hyperkalemia 119 Steven H. Mitchell and William J. Brady 17 Life- Threatening Electrocardiographic Patterns 125 Steven H. Mitchell, Richard B. Utarnachitt, and William J. Brady 18 The Electrocardiogram in Patients with Implanted Devices 130 Amita Sudhir and William J. Brady 19 Electrocardiographic Tools in Clinical Care 136 Robin Naples, Alvin Wang, and William J. Brady 20 Wolff–Parkinson–White Syndrome 143 William J. Brady 21 Cardiac Arrest Rhythms 147 Amita Sudhir and William J. Brady Section V Electrocardiographic Differential Diagnosis of Common ECG Presentations 153 22 Electrocardiographic Differential Diagnosis of Narrow Complex Tachycardia 155 Megan Starling and William J. Brady 23 Electrocardiographic Differential Diagnosis of Wide Complex Tachycardia 161 Amita Sudhir and William J. Brady 24 Electrocardiographic Differential Diagnosis of Bradyarrhythmia 170 Megan Starling and William J. Brady 25 Electrocardiographic Differential Diagnosis of ST Segment Elevation 175 Megan Starling and William J. Brady 26 Electrocardiographic Differential Diagnosis of ST Segment Depression 184 Amita Sudhir and William J. Brady 27 Electrocardiographic Differential Diagnosis of T Wave Abnormalities: The Prominent T Wave and T Wave Inversions 191 Amita Sudhir and William J. Brady Index 200
£33.24
John Wiley and Sons Ltd Endovascular Interventions
Book SynopsisA practical resource covering both elective and emergency procedures for the practicing vascular and endovascular clinician This book provides medical professionals (vascular surgeons, interventional cardiologists, interventional radiologists, endovascular neurologists, vascular medicine specialists) with a reference guide to the most common and accepted approach to endovascular management of peripheral vascular disease. It also addresses urgent interventions in the acute setting of the various vascular beds, and covers emerging areas such as stroke intervention and endovascular treatment of pulmonary embolism and vascular trauma. Edited by a multidisciplinary team, Endovascular Interventions offers in-depth coverage of the field in seven parts: Overview; Supra-Aortic Intervention in High Risk Patients: Innominate, Subclavian, Carotid, Vertebral and Intracranial Interventions; Interventions of the Aorta; Renal and Mesenteric Interventions; Lower Extremity Interventions; Venous DiseaTable of ContentsList of Contributors vii 1 Vascular Biology 1Cristina Sanina, Olga L. Bockeria, Karlo A. Wiley and Jonathan E. Feig 2 Non-Invasive Testing in Peripheral Arterial Disease 17Ian Del Conde and James F. Benenati 3 Carotid and Innominate Artery Stenting for High-Risk Patients 25Reid Ravin, Shivani Kumar and Peter Faries 4 Subclavian Artery Stenosis: When and How to Intervene 37Parham Parto and Tyrone J. Collins 5 Vertebral Artery Occlusive Disease 45Mark H.Wholey and Jason M. Andrus 6 Stroke Interventions 53Italo Linfante 7 Endovascular Management of Thoracoabdominal Aneurysms 61William E. Beckerman and James F. McKinsey 8 Abdominal Aortic Aneurysms: Catheter-Based Interventions 77Sean P. Wengerter, Kurt R. Wengerter and Michael L. Marin 9 Aortic Dissection: Urgent Endovascular Treatment 99Ratna C. Singh and Evan C. Lipsitz 10 Management of Acute Aortic Syndrome 111Rajesh Malik, Michael Siah and Edward Y.Woo 11 Severe Renal Artery Stenosis:When and How to Intervene 121Jose D. Tafur and Christopher J.White 12 Mesenteric Ischemia: Chronic and Acute Management 135Vincent Gallo, Kevin “Chaim” Herman and John H. Rundback 13 Catheter-Based Management of Peripheral AVMs 143Allan M. Conway, Alfio Carroccio and Robert J. Rosen 14 Aortoiliac Interventions 15Subhash Banerjee, Houman Khalili and Mehdi Shishehbor 15 Femoropopliteal Interventions in the Claudicant Patient 167Pedro A. Villablanca, Cristina Sanina, Pedro R. Cox-Alomar, Prakash Krishnan and Jose M.Wiley 16 Tibial and Pedal Plantar Interventions in Patients with Critical Limb Ischemia 183Anand Prasad and Haley Hughston 17 The Diagnosis, Evaluation and Contemporary Management of Acute Limb Ischemia 207Michael N. Young and Douglas E. Drachman 18 Pedal Reconstruction in Critical Limb Ischemia 221Amjad AlMahameed and Craig Walker 19 Access Site Complications 227Miguel Alvarez Villela, Fernando D. Pastor and Robert T. Pyo 20 Acute Deep Vein Thrombosis 243Ian Del Conde and James F. Benenati 21 Chronic Venous Disorders 251Brett J. Carroll, Duane S. Pinto and Cristina Sanina 22 Endovascular Treatment of Pulmonary Embolism 267Ian Del Conde and Barry T. Katzen 23 Inferior Vena Cava Filters 275Merrill H. Stewart and James S. Jenkins 24 Endovascular Treatment for Vascular Trauma 291Hallie E. Baer-Bositis, Georges M. Haidar, Taylor D. Hicks and Mark G. Davies Index 307
£98.96
John Wiley and Sons Ltd EvidenceBased Orthodontics
Book SynopsisEvidence-Based Orthodontics, Second Edition retains important elements of the First Edition, with several new sections to improve its use as a quick and comprehensive reference. New updated edition of a landmark text that surveys the principles and practice of evidence-based orthodontics Offers practical strategies for professionals to incorporate EBO in their daily practices Presents brief summaries of the best evidence for a wide range of clinical topics Incorporates information from over 400 systematic reviews, listed by topic Table of ContentsList of Contributors vii Foreword xi 1 Evidence‐Based Orthodontics – Its Evolution and Clinical Application 1Katherine W. L. Vig 2 Clinical Research Design 11Robert J. Weyant 3 Electronic Searching for Clinical Trials Information 25Anne Littlewood 4 Making Sense of Randomized Clinical Trials and Systematic Reviews 37Kevin O’Brien 5 Understanding and Improving our Evidence 49Padhraig Fleming, Greg J. Huang, and Nikolaos Pandis 6 Factors Influencing Facial Shape 69Stephen Richmond, Caryl Wilson-Nagrani, Alexei Zhurov, Damian Farnell, Jennifer Galloway,Azrul Safuan Mohd Ali, Pertti Pirttiniemi, and Visnja Katic Summaries of Selected Systematic Reviews 83 Summaries Contents 85 Preface to Summaries 91 Summaries 92 Additional References 205 Systematic Reviews in Orthodontics 209 Index 261
£71.96
John Wiley and Sons Ltd Atlas of Orthodontic Case Reviews
Book SynopsisAtlas of Orthodontic Case Reviews offers a comprehensive resource to the treatment of orthodontic malocclusions with a case-based approach.Table of ContentsPreface xiiixv Acknowledgments 1 Interceptive (Mixed Dentition): Case 1 1 Interview Data1 Clinical Examination1 Dentition 2 Right Buccal View 2 Left Buccal View 2 Maxillary Arch 2 Mandibular Arch 2 Function 3 Diagnosisand Treatment Plan 3 Treatment Objectives 5 Treatment Options 5 FirstActive Appointment with Quad-Helix in Place 6 Secondto Fourth Active Appointments 7 Six Months after Initial Placement of the Appliance 8 Commentary 9 Review Questions 10 Suggested References10 2 Interceptive (Mixed Dentition): Case 2 11 Interview Data 11 Clinical Examination 11 Dentition 12 Right Buccal View 12 Left Buccal View 12 Maxillary Arch 13 Mandibular Arch 13 Function 13 Diagnosisand Treatment Plan 14 Treatment Objectives15 Treatment Options15 FirstActive Appointment 16 SecondActive Appointment 17 ThirdActive Appointment 17 FourthActive Appointment 18 FifthActive Appointment 18 Phase ICompleted 19 Commentary 21 Review Questions 21 Suggested References 21 Phase I Treatment: Class III Skeletal and Class I Dental with Posterior and Anterior Crossbites 23 3 Interview Data 23 Clinical Examination 23 Dentition 24 Right Buccal View 24 Left Buccal View 24 Maxillary Arch 25 Mandibular Arch 25 Function25 Diagnosisand Treatment Plan 26 Treatment Objectives 27 Treatment Options 27 FirstActive Appointment 28 SecondActive Appointment 29 ThirdActive Appointment 30 FourthActive Appointment 31 FifthActive Appointment 32 SixthActive Appointment 32 Seventhand Eighth Active Appointments 33 Ninthand 10th Active Appointments 34 EleventhActive Appointment 35 TwelfthActive Appointment 36 Thirteenth Appointment36 Commentary39 Review Questions 40 Suggested References 40 4 Class I Skeletal and Class I Dental with Blocked-Out Maxillary Canine: Non-Extraction 41 Interview Data 41 Clinical Examination 41 Dentition 42 Right Buccal View 42 Left Buccal View 42 Maxillary Arch 43 Mandibular Arch 43 Function43 Diagnosisand Treatment Plan 44 Treatment Objectives 45 Treatment Options 45 FirstActive Appointment 46 SecondActive Appointment 47 Thirdto Fifth Active Appointments 48 Sixth Appointment 49 Commentary 53 Review Questions 53 Suggested References 53 5 Class I Skeletal and Class I Dental with a Deep Bite 55 Interview Data 55 Clinical Examination 55 Dentition 56 Right Buccal View 56 Left Buccal View 56 Maxillary Arch 57 Mandibular Arch 57 Function57 Treatment Objectives 59 Treatment Options 59 Firstand Second Active Appointments 60 ThirdActive Appointment 61 FourthActive appointment 62 FifthActive Appointment 63 SixthActive Appointment 64 SeventhActive Appointment 66 Eighthand Ninth Active Appointments 67 TenthActive Appointment 68 Eleventhand 12th Active Appointments 69 ThirteenthActive Appointment 69 FourteenthActive Appointment 70 Fifteenth Appointment71 Commentary74 Review Questions 74 Suggested References 74 6 Class I Skeletal and Class I Dental with Asymmetry: Non-Extraction 75 Interview Data 75 Clinical Examination 75 Dentition 76 Right Buccal View 76 Left Buccal View 76 Maxillary Arch 77 Mandibular Arch 77 Function77 Diagnosisand Treatment Plan 78 Treatment Objectives 79 Treatment Options 79 FirstActive Appointment 80 SecondActive Appointment 81 ThirdActive Appointment 82 FourthActive Appointment 83 FifthActive Appointment 84 Sixthand Seventh Active Appointments 85 EighthActive Appointment 85 Ninth Appointment86 Commentary90 Review Questions 90 Suggested References 90 7 Class II Skeletal and Class II Dental: Extraction of Maxillary First Premolars 91 Interview Data91 Clinical Examination91 Dentition 92 Right Buccal View 92 Left Buccal View 92 Maxillary Arch 93 Mandibular Arch 93 Function 93 Diagnosisand Treatment Plan 94 Treatment Objectives 95 Treatment Options 96 FirstActive Appointment 96 SecondActive Appointment 98 ThirdActive Appointment 99 FourthActive Appointment 100 FifthActive Appointment 101 Sixthand Seventh Active Appointments 102 EighthActive Appointment 103 Ninthand 10th Active Appointments 104 Eleventhand 12th Active Appointments 105 ThirteenthAppointment (Debond and Retainer Delivery) 105 Commentary108 Review Questions 108 Suggested References108 8 Class II Skeletal and Class II Dental: Non-Compliant 109 Interview Data109 Clinical Examination109 Dentition 110 Right Buccal View 110 Left Buccal View 110 Maxillary Arch 111 Mandibular Arch 111 Function111 Diagnosisand Treatment Plan 112 Treatment Objectives113 Treatment Options113 FirstActive Appointment 114 Secondand Third Active Appointments 115 Fourthand Fifth Active Appointments 116 SixthActive Appointment 117 Seventhand Eighth Active Appointments 118 Ninthto 12th Active Appointments 119 Thirteenth Appointment 120 FourteenthActive Appointment 122 Fifteenth Appointment122 Commentary125 Review Questions 126 Suggested References 126 9 Skeletal Class II and Dental Class II Division 1 Subdivision: Four Premolar Extractions 127 Interview Data 127 Clinical Examination127 Dentition 128 Right Buccal View 128 Left Buccal View 128 Maxillary Arch 129 Mandibular Arch 129 Function 129 Diagnosisand Treatment Plan 130 Treatment Objectives 131 Treatment Options 131 FirstActive Appointment 131 SecondActive Appointment 133 ThirdActive Appointment 134 Fourthand Fifth Active Appointments 135 SixthActive Appointment 136 SeventhActive Appointment 137 EighthActive Appointment 137 NinthActive Appointment 138 TenthActive Appointment 139 EleventhActive Appointment 140 TwelfthActive Appointment 141 ThirteenthActive Appointment 142 FourteenthActive Appointment 142 Fifteenthto 17th Active Appointments 143 Eighteenth Appointment 143 Commentary 145 Review Questions 147 Suggested References 147 10 Class III Skeletal Tendency and Class I Dental: Four Premolar Extractions 149 Interview Data 149 Clinical Examination 149 Dentition 150 Right Buccal View 150 Left Buccal View 150 Maxillary Arch 151 Mandibular Arch 151 Function 151 Diagnosisand Treatment Plan 152 Treatment Objectives 153 Treatment Options 153 Passive Appointments 153 FirstActive Appointment 154 SecondActive Appointment 155 ThirdActive Appointment 156 FourthActive Appointment 157 FifthActive Appointment 158 Sixthto Eighth Active Appointments 159 NinthActive Appointment 160 Tenthto 11th Active Appointments 161 Twelfthto 13th Active Appointments 162 FourteenthActive Appointment 163 FifteenthActive Appointment 163 Commentary 167 Review Questions 167 Suggested References 167 11 Class III Skeletal and Class III Dental: Non-Extraction and Non-Surgical 169 Interview Data 169 Clinical Examination 169 Dentition 170 Right Buccal View 170 Left Buccal View 170 Maxillary Arch 171 Mandibular Arch 171 Function 171 Diagnosisand Treatment Plan 172 Treatment Objectives 173 Treatment Options 173 FirstActive Appointment with Full Appliances Placed 174 SecondActive Appointment 175 ThirdActive Appointment 176 FourthActive Appointment 177 FifthActive Appointment 178 SixthActive Appointment 179 SeventhActive Appointment 179 Eighthand Ninth Active Appointments 180 Commentary183 Review Questions 183 Suggested References183 12 Class III Skeletal and Class III Dental: Non-Extraction 185 Interview Data 185 Clinical Examination 185 Dentition 186 Right Buccal View 186 Left Buccal View 186 Maxillary Arch 187 Mandibular Arch 187 Function187 Diagnosisand Treatment Plan 188 Treatment Objectives189 Treatment Options189 FirstActive Appointment 190 SecondActive Appointment 191 ThirdActive Appointment 192 FourthActive Appointment 193 FifthActive Appointment 194 SixthActive Appointment 195 Seventhto Eighth Active Appointments 196 NinthActive Appointment 196 TenthActive Appointment 197 Tenth Appointment 198 Commentary 201 Review Questions 201 Suggested Reference 201 13 Class III Skeletal Pattern and Class II Dental: Non-Extraction 203 Interview Data 203 Clinical Examination 203 Dentition 204 Right Buccal View 204 Left Buccal View 204 Maxillary Arch 205 Mandibular Arch 205 Function 205 Diagnosisand Treatment Plan 206 Treatment Objectives 207 Treatment Options 207 FirstActive Appointment 207 SecondActive Appointment 208 Thirdto Fourth Active Appointment 209 FifthActive Appointment 210 SixthActive Appointment 211 SeventhActive Appointment 212 EighthActive Appointment 213 Ninth Appointment 213 Commentary 216 Review Questions 217 Suggested References 217 14 Class III Skeletal and Class I Dental: Four Premolar Extractions 219 Interview Data 219 Clinical Examination 219 Dentition 220 Right Buccal View 220 Left Buccal View 220 Maxillary Arch 221 Mandibular Arch 221 Function 221 Diagnosisand Treatment Plan 222 Treatment Objectives 223 Treatment Options 223 FirstActive Appointment 223 SecondActive Appointment 224 ThirdActive Appointment 225 FourthActive Appointment 226 FifthActive Appointment 227 SixthActive Appointment 228 SeventhActive Appointment 229 EighthActive Appointment 230 NinthActive Appointment 231 TenthActive Appointment 232 Eleventhto 12th Active Appointments 233 ThirteenthActive Appointment 234 FourteenthActive Appointment 235 Fifteenth Appointment236 Commentary239 Review Questions 239 Suggested References 239 15 Class III Surgical 241 Interview Data241 Clinical Examination241 Dentition 242 Right Buccal View 242 Left Buccal View 242 Maxillary Arch 243 Mandibular Arch 243 Function 243 Diagnosisand Treatment Plan 244 Treatment Objectives 244 Treatment Options 245 FirstActive Appointment 247 Secondand Third Active Appointments 248 FourthActive Appointment 248 Fifthand Sixth Active Appointments 248 SeventhActive Appointment 250 EighthActive Appointment 250 FirstPost-Surgical Appointment 251 SecondPost-Surgical Appointment 253 ThirdPost-Surgical Appointment 253 Commentary 256 Review Questions 256 Suggested References 256 Index 257
£102.55
John Wiley and Sons Ltd Statistics at Square Two
Book SynopsisSTATISTICS AT SQUARE TWO An easy-to-follow exploration of intermediate statistical techniques used in medical research In the newly revised third edition of Statistics at Square Two: Understanding Modern Statistical Applications in Medicine, a team of distinguished statisticians delivers an accessible and intuitive discussion of advanced statistical methods for readers and users of scientific medical literature. This will allow readers to engage critically with modern research as the authors explain the correct interpretation of results in the medical literature. The book includes two brand new chapters covering meta-analysis and time-series analysis as well as new references to the many checklists that have appeared in recent years to enable better reporting of contemporary research. Most examples have been updated as well, and each chapter contains practice exercises and answers. Readers will also find sample code (in R) for many of the analyses, in addition toTable of ContentsPreface xi 1 Models, Tests and Data 1 1.1 Types of Data 1 1.2 Confounding, Mediation and Effect Modification 2 1.3 Causal Inference 3 1.4 Statistical Models 5 1.5 Results of Fitting Models 6 1.6 Significance Tests 7 1.7 Confidence Intervals 8 1.8 Statistical Tests Using Models 8 1.9 Many Variables 9 1.10 Model Fitting and Analysis: Exploratory and Confirmatory Analyses 10 1.11 Computer-intensive Methods 11 1.12 Missing Values 11 1.13 Bayesian Methods 12 1.14 Causal Modelling 12 1.15 Reporting Statistical Results in the Medical Literature 14 1.16 Reading Statistics in the Medical Literature 14 2 Multiple Linear Regression 17 2.1 The Model 17 2.2 Uses of Multiple Regression 18 2.3 Two Independent Variables 18 2.3.1 One Continuous and One Binary Independent Variable 19 2.3.2 Two Continuous Independent Variables 22 2.3.3 Categorical Independent Variables 22 2.4 Interpreting a Computer Output 23 2.4.1 One Continuous Variable 24 2.4.2 One Continuous Variable and One Binary Independent Variable 25 2.4.3 One Continuous Variable and One Binary Independent Variable with Their Interaction 26 2.4.4 Two Independent Variables: Both Continuous 27 2.4.5 Categorical Independent Variables 29 2.5 Examples in the Medical Literature 31 2.5.1 Analysis of Covariance: One Binary and One Continuous Independent Variable 31 2.5.2 Two Continuous Independent Variables 32 2.6 Assumptions Underlying the Models 32 2.7 Model Sensitivity 33 2.7.1 Residuals, Leverage and Influence 33 2.7.2 Computer Analysis: Model Checking and Sensitivity 34 2.8 Stepwise Regression 35 2.9 Reporting the Results of a Multiple Regression 36 2.10 Reading about the Results of a Multiple Regression 36 2.11 Frequently Asked Questions 37 2.12 Exercises: Reading the Literature 38 3 Multiple Logistic Regression 41 3.1 Quick Revision 41 3.2 The Model 42 3.2.1 Categorical Covariates 44 3.3 Model Checking 44 3.3.1 Lack of Fit 45 3.3.2 “Extra-binomial” Variation or “Over Dispersion” 45 3.3.3 The Logistic Transform is Inappropriate 46 3.4 Uses of Logistic Regression 46 3.5 Interpreting a Computer Output 47 3.5.1 One Binary Independent Variable 47 3.5.2 Two Binary Independent Variables 51 3.5.3 Two Continuous Independent Variables 53 3.6 Examples in the Medical Literature 54 3.6.1 Comment 55 3.7 Case-control Studies 56 3.8 Interpreting Computer Output: Unmatched Case-control Study 56 3.9 Matched Case-control Studies 58 3.10 Interpreting Computer Output: Matched Case-control Study 58 3.11 Example of Conditional Logistic Regression in the Medical Literature 60 3.11.1 Comment 60 3.12 Alternatives to Logistic Regression 61 3.13 Reporting the Results of Logistic Regression 61 3.14 Reading about the Results of Logistic Regression 61 3.15 Frequently Asked Questions 62 3.16 Exercise 62 4 Survival Analysis 65 4.1 Introduction 65 4.2 The Model 66 4.3 Uses of Cox Regression 68 4.4 Interpreting a Computer Output 68 4.5 Interpretation of the Model 70 4.6 Generalisations of the Model 70 4.6.1 Stratified Models 70 4.6.2 Time Dependent Covariates 71 4.6.3 Parametric Survival Models 71 4.6.4 Competing Risks 71 4.7 Model Checking 72 4.8 Reporting the Results of a Survival Analysis 73 4.9 Reading about the Results of a Survival Analysis 74 4.10 Example in the Medical Literature 74 4.10.1 Comment 75 4.11 Frequently Asked Questions 76 4.12 Exercises 77 5 Random Effects Models 79 5.1 Introduction 79 5.2 Models for Random Effects 80 5.3 Random vs Fixed Effects 81 5.4 Use of Random Effects Models 81 5.4.1 Cluster Randomised Trials 81 5.4.2 Repeated Measures 82 5.4.3 Sample Surveys 83 5.4.4 Multi-centre Trials 83 5.5 Ordinary Least Squares at the Group Level 84 5.6 Interpreting a Computer Output 85 5.6.1 Different Methods of Analysis 85 5.6.2 Likelihood and gee 85 5.6.3 Interpreting Computer Output 86 5.7 Model Checking 89 5.8 Reporting the Results of Random Effects Analysis 89 5.9 Reading about the Results of Random Effects Analysis 90 5.10 Examples of Random Effects Models in the Medical Literature 90 5.10.1 Cluster Trials 90 5.10.2 Repeated Measures 91 5.10.3 Comment 91 5.10.4 Clustering in a Cohort Study 91 5.10.5 Comment 91 5.11 Frequently Asked Questions 91 5.12 Exercises 92 6 Poisson and Ordinal Regression 95 6.1 Poisson Regression 95 6.2 The Poisson Model 95 6.3 Interpreting a Computer Output: Poisson Regression 96 6.4 Model Checking for Poisson Regression 97 6.5 Extensions to Poisson Regression 99 6.6 Poisson Regression Used to Estimate Relative Risks from a 2 × 2 Table 99 6.7 Poisson Regression in the Medical Literature 100 6.8 Ordinal Regression 100 6.9 Interpreting a Computer Output: Ordinal Regression 101 6.10 Model Checking for Ordinal Regression 103 6.11 Ordinal Regression in the Medical Literature 104 6.12 Reporting the Results of Poisson or Ordinal Regression 104 6.13 Reading about the Results of Poisson or Ordinal Regression 104 6.14 Frequently Asked Question 105 6.15 Exercises 105 7 Meta-analysis 107 7.1 Introduction 107 7.2 Models for Meta-analysis 108 7.3 Missing Values 111 7.4 Displaying the Results of a Meta-analysis 111 7.5 Interpreting a Computer Output 113 7.6 Examples from the Medical Literature 114 7.6.1 Example of a Meta-analysis of Clinical Trials 114 7.6.2 Example of a Meta-analysis of Case-control Studies 115 7.7 Reporting the Results of a Meta-analysis 115 7.8 Reading about the Results of a Meta-analysis 116 7.9 Frequently Asked Questions 116 7.10 Exercise 118 8 Time Series Regression 121 8.1 Introduction 121 8.2 The Model 122 8.3 Estimation Using Correlated Residuals 122 8.4 Interpreting a Computer Output: Time Series Regression 123 8.5 Example of Time Series Regression in the Medical Literature 124 8.6 Reporting the Results of Time Series Regression 125 8.7 Reading about the Results of Time Series Regression 125 8.8 Frequently Asked Questions 125 8.9 Exercise 126 Appendix 1 Exponentials and Logarithms 129 Appendix 2 Maximum Likelihood and Significance Tests 133 A2. 1 Binomial Models and Likelihood 133 A. 2 The Poisson Model 135 A2. 3 The Normal Model 135 A2. 4 Hypothesis Testing: the Likelihood Ratio Test 137 A2. 5 The Wald Test 138 A2. 6 The Score Test 138 A2. 7 Which Method to Choose? 139 A2. 8 Confidence Intervals 139 A2. 9 Deviance Residuals for Binary Data 140 A2. 10 Example: Derivation of the Deviances and Deviance Residuals Given in Table 3.3 140 A2.10.1 Grouped Data 140 A2.10.2 Ungrouped Data 140 Appendix 3 Bootstrapping and Variance Robust Standard Errors 143 A3.1 The Bootstrap 143 A3.2 Example of the Bootstrap 144 A3.3 Interpreting a Computer Output: The Bootstrap 145 A3.3.1 Two-sample T-test with Unequal Variances 145 A3.4 The Bootstrap in the Medical Literature 145 A3.5 Robust or Sandwich Estimate SEs 146 A3.6 Interpreting a Computer Output: Robust SEs for Unequal Variances 147 A3.7 Other Uses of Robust Regression 149 A3.8 Reporting the Bootstrap and Robust SEs in the Literature 149 A3.9 Frequently Asked Question 150 Appendix 4 Bayesian Methods 151 A4.1 Bayes’ Theorem 151 A4.2 Uses of Bayesian Methods 152 A4.3 Computing in Bayes 153 A4.4 Reading and Reporting Bayesian Methods in the Literature 154 A4.5 Reading about the Results of Bayesian Methods in the Medical Literature 154 Appendix 5 R codes 157 A5. 1 R Code for Chapter 2 157 A5. 3 R Code for Chapter 3 163 A5. 4 R Code for Chapter 4 166 A. 5 R Code for Chapter 5 168 A5. 6 R Code for Chapter 6 170 A5. 7 R Code for Chapter 7 171 A5. 8 R Code for Chapter 8 173 A5. 9 R Code for Appendix 1 173 A5. 10 R Code for Appendix 2 174 A5. 11 R Code for Appendix 3 175 Answers to Exercises 179 Glossary 185 Index 191
£28.49
John Wiley and Sons Ltd Platelet Rich Fibrin in Regenerative Dentistry
Book SynopsisThe first book devoted exclusively to the subject, Platelet Rich Fibrin in Regenerative Dentistry offers comprehensive, evidence-based coverage of the biological basis and clinical applications of PRF in dentistry. Co-edited by a leading researcher in tissue regeneration and the inventor of the PRF technique, it brings together original contributions from expert international researchers and clinicians. Chapters cover the biological foundation of PRF before addressing specific uses of the technology within clinical dentistry. Topics describe the use of PRF in many dental applications, including extraction socket management, sinus lifting procedures, root coverage, periodontal regeneration, soft tissue healing around implants,guided bone regeneration, and facial esthetics. The text is supplemented with color photographs and explanatory illustrations throughout. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical IndicationTable of ContentsContributorsForeword Preface Chapter 1: Platelet Rich Fibrin: A 2nd generation platelet concentrateJoseph Choukroun, Richard J MironChapter 2: Biological Components of Platelet Rich Fibrin: Growth Factor Release and Cellular Activity Masako Fujioka-Kobayashi, Richard J MironChapter 3: Introducing the Low-Speed Centrifugation Concept Joseph Choukroun, Shahram GhanaatiChapter 4: Uses of Platelet Rich Fibrin in Regenerative Dentistry: an Overview Richard J Miron, Giovanni Zucchelli, Joseph ChoukrounChapter 5: Use of Platelet Rich Fibrin for the Management of Extraction Sockets: Biological Basis and Clinical Relevance Richard J Miron, Jonathan de ToitChapter 6: Maxillary Sinus Floor Elevation in the Atrophic Posterior Maxillae: Anatomy, Principles, Techniques, Outcomes and Complications Alberto Monje, Hom-Lay Wang, Richard J MironChapter 7: Maxillary Sinus Floor Elevation Procedures with Platelet Rich Fibrin: Indications and Clinical Recommendations Richard J Miron, Michael A Pikos, Hom-Lay Wang Chapter 8: Use of Platelet Rich Fibrin for the treatment of muco-gingival recessions: Novel Improvements in Plastic Esthetic Surgery utilizing The Fibrin Assisted Soft Tissue Promotion (FASTP) Technique Alexandre-Amir Aalam, Alina Krivitsky AalamChapter 9: Use of Platelet Rich Fibrin for Periodontal Regeneration/Repair of Intrabony and Furcation Defects Richard J Miron, Brian L Mealey, Hom-Lay WangChapter 10: Platelet Rich Fibrin as an Adjunct to Implant Dentistry Howard GluckmanChapter 11: Guided Bone Regeneration with Platelet Rich Fibrin Richard J Miron, Michael A Pikos, Yufeng Zhang, Tobias FretwurstChapter 12: Modern Approach to Full Arch Immediate Loading: The Simonpieri Technique with PRF and i-PRF Alain SimonpieriChapter 13: Use of Platelet Rich Fibrin in Facial Esthetics and Rejuvenation Cleopatra NacopoulosChapter 14: Use of Platelet Rich Fibrin in Other Areas of Medicine Richard J Miron, Joseph ChoukrounChapter 15: Future Research with Platelet Rich Fibrin Richard J Miron, Joseph Choukroun
£98.96
John Wiley and Sons Ltd Morson and Dawsons Gastrointestinal Pathology
Book Synopsis
£194.36
John Wiley and Sons Ltd Endodontic Materials in Clinical Practice
Book SynopsisEndodontic Materials in Clinical Practice Endodontic Materials in Clinical Practice delivers a much-needed comprehensive and clinically oriented reference to the materials used in endodontic practice. It provides complete details on the properties of the materials required for specific techniques in order to help in the selection of the appropriate materials and improve patient outcomes. Comprehensive in scope and filled with helpful illustrations, the book covers endodontic materials used from the pulp to the root-end. In addition, the text considers the location and technique for each of the materials presented. Designed to be a practical and accessible reference, the book is organised by specific clinical procedure. Presents an illustrated guide to all materials used in endodontic practiceFocuses on the clinical application for each materialExplains why specific materials are usedIncludes information on how to select the correct materialConsiders locations and techniques in makiTable of ContentsList of Contributors xi 1 Introduction: Materials Chemistry as a Means to an End(o) – The Invisible Foundation 1Brian W. Darvell 1.1 Introduction 1 1.2 The Substrate 2 1.3 Nomenclatural Hype: ‘Bioactivity’, ‘Bioceramics’ 3 1.4 Chemical Interactions and Irrigation 6 1.5 Terminology 9 1.6 Classification of HSCs 11 1.7 Conclusion 12 References 13 2 Pulp Capping Materials for the Maintenance of Pulp Vitality 15Phillip L. Tomson and Henry F. Duncan 2.1 Introduction 16 2.2 Maintaining Pulp Vitality 16 2.2.1 Why Maintain the Pulp? 16 2.2.2 Pulpal Irritants 16 2.2.3 Pulpal Healing After Exposure 17 2.2.4 Classifications of Pulpitis and Assessing the Inflammatory State of the Pulp 18 2.2.5 Is Pulpal Exposure a Negative Prognostic Factor? 19 2.2.6 Soft Tissue Factors Related to the Tooth 19 2.3 Clinical Procedures for Maintaining Pulp Vitality 21 2.3.1 Managing the Unexposed Pulp 21 2.3.2 Tooth Preparation to Avoid Exposure 21 2.3.3 Managing the Exposed Pulp 21 2.3.3.1 Direct Pulp Capping 22 2.3.3.2 Partial Pulpotomy 22 2.3.3.3 Full Pulpotomy 22 2.3.3.4 Pulpectomy 23 2.3.4 Immature Roots 24 2.4 Materials Used in Vital Pulp Treatment 25 2.4.1 The Role of the Material 25 2.4.2 Calcium Hydroxide 25 2.4.3 Resin-Based Adhesives 27 2.4.4 Hydraulic Calcium Silicate Cements 27 2.4.5 Resin-Based Hydraulic Calcium Silicate Cements 29 2.4.6 Glass Ionomer Cements 30 2.4.7 Experimental Agents Used in Vital Pulp Treatment 31 2.4.8 Tooth Restoration After VPT 32 2.5 Clinical Outcome and Practicalities 32 2.5.1 Vital Pulp Treatment Outcome 32 2.5.2 Discolouration 32 2.5.3 Setting Time and Handling 33 2.6 Conclusion 33 References 34 3 Treatment of Immature Teeth with Pulp Necrosis 47Paul Cooper, Henry F. Duncan, Matthias Widbiller, and Kerstin M. Galler 3.1 Introduction 48 3.2 Apexification and Root-End Closure 49 3.3 Revitalization 50 3.3.1 Indications 50 3.3.2 Procedure 51 3.3.3 Outcome 51 3.3.4 Limitations 52 3.4 Material Requirements 52 3.4.1 Materials and Applications 52 3.4.2 Biological Requirements 54 3.4.2.1 Bioactivity 54 3.4.2.2 Reaction with Tissue Fluids 54 3.4.2.3 Release of Dentine Matrix Proteins 55 3.4.2.4 Blood Clot 55 3.4.3 Mechanical Requirements 55 3.4.3.1 Impact on Microhardness 55 3.4.3.2 Discolouration 56 3.5 Healing Process and Cellular Responses 57 3.5.1 Biological Aspects 57 3.5.2 Mineralization 60 3.6 Future Directions: Tissue Engineering Approaches 62 3.6.1 Principles of Tissue Engineering 62 3.6.2 Dentine Matrix Proteins and Epigenetic Influences 63 3.6.2.1 Dentine Matrix Components 63 3.6.2.2 Growth Factors and Molecular Modulators 63 3.6.2.3 Epigenetic Influences 64 3.6.3 Cell-Based and Cell-Free Dental Pulp Tissue Engineering 65 3.6.4 Clinical Approaches and Future Perspectives 66 3.7 Conclusion 66 References 66 4 Endodontic Instruments and Canal Preparation Techniques 81Laurence Jordan, Francois Bronnec, and Pierre Machtou 4.1 Classification and Components of Endodontic Instruments 82 4.1.1 Brief History 82 4.1.2 Alloys 84 4.1.2.1 Carbon Steel versus Stainless Steel 84 4.1.2.2 Nickel–Titanium 84 4.1.3 Manufacture and Standardization 85 4.1.3.1 Standardization of Stainless-Steel Instruments 85 4.1.3.2 Design of Endodontic Instruments: Terms and Definitions 86 4.1.3.3 Physical Properties of Endodontic Instruments: Terms and Definitions 90 4.1.4 Cleaning and Shaping Instruments 90 4.1.4.1 Group 1: Instruments for Hand Use (K-Files, H-Files, Barbed Broaches, Rasps) 90 4.1.4.2 Group 2: Engine-Driven Latch-Type Instruments 94 4.1.4.3 Group 3: Engine-Driven NiTi Rotary Instruments 94 4.1.4.4 Group 4: Engine-Driven Instruments that Adapt Themselves to the Root Canal Anatomy 98 4.1.4.5 Group 5: Engine-Driven Reciprocating Instruments 99 4.1.4.6 Group 6: Sonic and Ultrasonic Instruments 99 4.2 Properties of NiTi Alloys and Improvements by Thermomechanical Treatments 101 4.2.1 Martensitic Transformation 101 4.2.2 Pseudoelastic Properties 102 4.2.3 Transformation Temperatures 104 4.2.4 Manufacturing Processes 105 4.2.5 Flexibility 109 4.2.6 Clinical Implications 112 4.3 Concepts in Root Canal Shaping 112 4.3.1 Instrument Motions 113 4.3.2 Canal Management Strategies 114 4.4 Conclusion 124 References 125 5 Irrigating Solutions, Devices, and Techniques 133Christos Boutsioukis and Maria Teresa Arias-Moliz 5.1 Introduction 134 5.2 Irrigating Solutions 134 5.2.1 Sodium Hypochlorite 134 5.2.2 Chlorhexidine 136 5.2.3 Ethylenediamine Tetraacetic Acid 136 5.2.4 Citric Acid 137 5.2.5 Etidronic Acid 138 5.2.6 Maleic Acid 138 5.2.7 Ozonated Water 138 5.2.8 Electrochemically Activated Water 139 5.2.9 Saline 139 5.2.10 Mixtures of Irrigating Solutions 139 5.2.10.1 BioPure MTAD 140 5.2.10.2 Tetraclean 140 5.2.10.3 QMix 141 5.2.11 Suggested Irrigation Protocol 141 5.3 Irrigation Techniques 141 5.3.1 Irrigant Delivery Techniques 142 5.3.1.1 Syringe Irrigation 142 5.3.1.2 Negative-Pressure Irrigation 147 5.3.1.3 Combined Positive- and Negative-Pressure Irrigation 149 5.3.2 Irrigant Activation and Agitation Techniques 149 5.3.2.1 Ultrasonic Activation 149 5.3.2.2 Sonic Agitation 152 5.3.2.3 Laser Activation 154 5.3.2.4 Manual Dynamic Agitation 156 5.3.3 Combinations of Techniques 156 5.3.3.1 Continuous Irrigant Delivery and Ultrasonic Activation 156 5.3.3.2 Continuous Irrigant Delivery and Multisonic Activation 157 5.4 Final Remarks 158 References 159 6 Root Canal Filling Materials and Techniques 181Bun San Chong and Nicholas Chandler 6.1 Introduction 182 6.2 Root Canal Obturation Materials 182 6.2.1 Sealers 182 6.2.1.1 Zinc Oxide-Eugenol Sealers 183 6.2.1.2 Calcium Hydroxide Sealers 184 6.2.1.3 Glass Ionomer Sealers 185 6.2.1.4 Resin Sealers 186 6.2.1.5 Silicone Sealers 187 6.2.1.6 HCSC Sealers 187 6.2.1.7 Other Sealer Types 190 6.2.2 Core Materials 190 6.2.2.1 Silver Points 190 6.2.2.2 Acrylic Points 191 6.2.2.3 Gutta-Percha 191 6.3 Root Filling Techniques 193 6.3.1 Cold Gutta-Percha Condensation Techniques 194 6.3.1.1 Lateral Condensation 194 6.3.1.2 Single-Cone Obturation 195 6.3.2 Heat-Softened Gutta-Percha Techniques 196 6.3.2.1 Intracanal Heating Techniques 197 6.3.2.2 Extracanal Heating Techniques 198 6.3.3 Thermomechanical Compaction 199 6.3.3.1 Vibration and Heat 199 6.3.3.2 Rotating Condenser 199 6.3.4 Other Obturation Techniques 200 6.3.4.1 Pastes 200 6.3.4.2 HCSCs 201 6.3.4.3 Monoblocks 202 6.3.4.4 Hydrophilic Polymers 202 6.4 Orifice Barrier Materials and Tooth Restoration 203 6.5 Retreatment 203 6.6 Conclusion 205 References 205 7 Root-End Filling and Perforation Repair Materials and Techniques 219Josette Camilleri and Christof Pertl 7.1 Introduction 219 7.2 The Surgical Environment 220 7.3 Materials for Endodontic Surgery 224 7.3.1 Conventional Materials 224 7.3.1.1 Zinc Oxide-Eugenol Cements 225 7.3.1.2 Glass Ionomer Cements 228 7.3.1.3 Filled Resin and Dentine Bonding Systems 231 7.3.1.4 Other Materials and Techniques 233 7.3.2 Hydraulic Cements 233 7.3.2.1 Portland Cement-Based Hydraulic Cements: Types 1–3 234 7.3.2.2 Tricalcium Silicate Cement-Based Hydraulic Cements: Types 4 and 5 245 7.4 Conclusion 248 Acknowledgements 248 References 248 8 Materials and Clinical Techniques for Endodontic Therapy of Deciduous Teeth 263Nastaran Meschi, Mostafa EzEldeen, Gertrude Van Gorp, and Paul Lambrechts 8.1 Introduction 263 8.2 The Primary Dentine–Pulp Complex 264 8.3 Pulp Treatments in Deciduous Teeth 264 8.3.1 Vital Pulp Therapy 264 8.3.1.1 Incomplete Caries Removal 264 8.3.1.2 Complete Caries Removal 266 8.3.1.3 Restorative Materials for VPT of Deciduous Teeth 267 8.3.2 Pulpectomy 275 8.3.2.1 Technique 275 8.3.2.2 Restorative Materials 278 8.4 Conclusion 280 References 280 9 Adhesion to Intraradicular and Coronal Dentine: Possibilities and Challenges 289Mutlu Özcan, Claudia Angela Maziero Volpato, and Luiz Fernando D’Altoé 9.1 Introduction 289 9.2 Adhesion to Human Dentine 290 9.3 Adhesion to Root Dentine in Vital Teeth 292 9.4 Pulp Protection Materials and Their Effect on Adhesion to Dentine 293 9.5 Adhesion to Root Dentine in Nonvital Teeth 294 9.6 Conclusion 298 References 298 Index 305
£116.96
John Wiley and Sons Ltd Chronic Total Occlusions
Book SynopsisUnderstand and remedy chronic total occlusions with the third edition of this comprehensive guide Chronic Total Occlusions offers the most comprehensive overview of chronic total occlusions (CTO) on the market, authored by two internationally recognized physician educators. It covers both the diagnostic modalities and treatment methods required to tailor a treatment program to individual cardiological patients with the greatest possible chance of success. Thorough and informed by the latest research and field data, the third edition of this guide is an indispensable resource for interventional cardiologists. In Chronic Total Occlusions: A Guide to Recanalization, Third Edition, readers will also find: Full-color images to guide diagnosis of CTOsExpert tips and tricks for key procedures involved in treating challenging casesClinical case studies illustrating specific scenarios and frequently encountered complications Chronic Total Occlusions: A Guide to Recanalization, Third Edition is Table of ContentsList of Contributors vii Foreword x Preface xii Part I Pathology, Indications, and Review of Clinical Trials 1 The Pathobiology of CTO 3 Gabby Elbaz-Greener & Bradley H. Strauss 2 Pathology of Chronic Total Occlusions: Implications for Revascularization 10 Takao Konishi, Ji Eun Park, Diljon S. Chahal & Aloke V. Finn 3 Indications and Guidelines of PCI for CTO 19 Ilan Merdler, Gabriel Maluenda & Ron Waksman Part II Imaging 4 CT Angiography: Application in Chronic Total Occlusions 29 Hidehiko Hara, John R. Lesser, Nicholas Burke & Robert S. Schwartz 5 IVUS-Guided Recanalization of CTO 35 Etsuo Tsuchikane 6 Optical Coherence Tomography to Guide the Treatment of Chronic Total Occlusions 39 Francesca Maria Di Muro, Giulia Nardi, Niccolò Ciardetti, Selcuk Kucukseymen, Alessio Mattesini & Carlo Di Mario Part III Wires Technology 7 New Coronary Guidewire Technology in Chronic Total Occlusion Percutaneous CoronaryInterventions 49 Salman Allana & Emmanouil S. Brilakis 8 Tornus Catheter 64 Hideaki Kaneda 9 Microcatheters: Characteristics and Use 69 John D. Hung & James C. Spratt Part IV Wires Technique 10 CTO Wires: Engineering 101 and Principles of Wire Manipulation 83 Rahul Kurup & Luiz Fernando Ybarra 11 Use of Two Wires in the Treatment of CTO 101 Thierry Lefèvre & Thomas Hovasse 12 Parallel-Wire Techniques 109 Sudhir Rathore & Takahiko Suzuki 13 Transradial Approach for CTO Lesions 115 Yutaka Tanaka & Shigeru Saito 14 Subintimal Angioplasty in Coronary CTO 121 Negar Salehi, Philippe Généreux & George D. Dangas 15 Antegrade Dissection and Re-Entry Techniques 129 Anbukarasi Maran, Carson Keck & Matthew C. Evans 16 3D Wiring Methods in CTO PCI 135 Atsunori Okamura 17 Antegrade Fenestration and Re-Entry: An Alternative Approach to Antegrade Dissection and Re-Entry 156 Lorenzo Azzalini & Mauro Carlino 18 Retrograde CTO PCI: Step by Step 166 Michael Megaly & Ashish Pershad 19 Retrograde CTO Intervention via Vein Grafts 172 Pavan Reddy & Nelson L. Bernardo 20 Tips and Tricks of the CART and Reverse CART Technique 177 Arber Kodra, Chad Kliger, Apurva Patel, Craig Basman, Tak Kwan & Michael Kim 21 Debulking of CTO 181 Etsuo Tsuchikane 22 Laser Revascularization in Coronary CTO 186 On Topaz 23 How to Handle Subintimal Dissections 203 Pratik B. Sandesara & William J. Nicholson 24 CTO: How to Minimize Contrast-Associated Acute Kidney Injury 218 Luis Gruberg 25 Mechanical Support for CTO 232 Khaldoon Alaswad, Asaad Nakhle, Ankur Gupta, Katherine J. Kunkel & Mir Babar Basir 26 Stent Grafts to Seal Coronary Perforation 246 Jasleen Tiwana & Kathleen E. Kearney 27 Complications During Retrograde Approach for CTO 250 Yutaka Tanaka & Shigeru Saito Part V Interesting Cases 28 Interesting Cases I–V 257 Yutaka Tanaka & Shigeru Saito Index 263
£117.00
John Wiley and Sons Ltd Successful Training in Gastrointestinal Endoscopy
Book SynopsisTable of ContentsList of Contributors, viii Foreword, xii Preface, xiii Acknowledgments, xv About the Companion Website, xvi Part I The Evolution of Basic Principles and Practice, 1 1 Training in Endoscopy: A Historical Background, 3Jonathan Cohen and David A. Greenwald 2 How Endoscopy is Learned: Deconstructing Skill Sets, 20Kevin A. Waschke, Catharine M. Walsh, and Gerald M. Fried 3 Training to Become a High‐Quality Endoscopist: Mastering the Nonprocedural Aspects, 27Sahar Ghassemi and Douglas O. Faigel 4 Training the Endoscopic Trainer, 33Catharine M. Walsh and Kevin A. Waschke Part II Training in the Major Endoscopic Procedures, 43 5 Esophagogastroduodenoscopy (EGD), 45Susan Y. Quan, Lauren B. Gerson, Thomas E. Kowalski, and Shai Friedland 6 Colonoscopy, 57Robert E. Sedlack 7 Endoscopic Ultrasound, 88Thomas J. Savides and Frank G. Gress 8 ERCP, 99Brian S. Lim, Joseph Leung, and Wei‐Chih Liao 9 Capsule Endoscopy, 113Mindy W. Lee and Felice Schnoll‐Sussman 10 Deep Enteroscopy, 125Jorge D. Machicado, Jonathan M. Buscaglia, and Patrick I. Okolo 11 Cholangioscopy and Pancreatoscopy, 133Amrita Sethi and Raj J. Shah 12 Principles of Electrosurgery, 143David L. Carr‐Locke and John Day 13 Training in the Use of Fluoroscopy for Gastrointestinal Endoscopy, 153Douglas G. Adler and Gandhi Lanke 14 Training in Pediatric Endoscopy, 164Michael A. Manfredi and Jenifer R. Lightdale Part III Training in Specific Techniques, 177 15 Contrast‐Enhanced Endoscopy: Chromo and Optical Contrast Techniques, 179Anna M. Buchner, Prateek Sharma, and Michael B. Wallace 16 Training in GI Hemostasis, 195Dennis M. Jensen 17 Luminal Dilation Techniques (Strictures, Achalasia, Anastomotic, IBD), 215Yi Jia, Syed M. Abbas Fehmi, and Michael L. Kochman 18 Management of Foreign Body Ingestion and Esophageal Food Bolus Obstruction, 224Michael S. Green, Wendell K. Clarkston, and Sreenivasa S. Jonnalagadda 19 Endoscopic Mucosal Resection, Submucosal Dissection, and Full Thickness Resection Techniques, 233Juergen Hochberger, Edris Wedi, Peter Koehler, SongSa Dammer, and Thomas Brunk 20 Mucosal Ablation Techniques, 273Fariha H. Ramay, Bruce D. Greenwald, Virender K. Sharma, and John A. Dumot 21 Complicated Polypectomy, 284Neal Shahidi, Michael J. Bourke, Yasushi Sano, and Jerome D. Waye 22 Training and Credentialing in Natural Orifice Transluminal Endoscopic Surgery (NOTES), 303David J. Desilets 23 Training in Bariatric Endoscopy, 306Diogo Turiani Hourneaux de Moura, Pichamol Jirapinyo, and Christopher C. Thompson 24 Repair of Mucosal Defects: A Primer on Endoscopic Closure of Gastrointestinal Perforations, 323Sergey V. Kantsevoy and Gottumukkala S. Raju 25 Esophageal, Gastroduodenal, and Colorectal Stenting, 331Peter D. Siersema 26 ERCP Management of Complicated Stone Disease of the Bile Duct and Pancreas, 343Nithin Karanth, Ashley A. Vareedayah, Jonathan Cohen, and Gregory B. Haber 27 ERCP Management of Malignancy: Tissue Sampling, Metal Stent Placement, and Ampullectomy, 356Douglas A. Howell 28 Sphincter of Oddi Manometry, 366Mark A. Gromski, Stuart Sherman, Glen A. Lehman, and Evan L. Fogel 29 Training for Pseudocyst Management, 375Todd H. Baron 30 Enteral Access Techniques: Percutaneous Endoscopic Gastrostomy and Jejunostomy, 384Lauren K. Schwartz and James A. DiSario 31 Training in GI Upper Motility Techniques, 395Anthony Lembo and Raxitkumar Patel 32 Training in the Endoscopic Management of Anorectal Disorders, 410Waqar Qureshi 33 The Endoscopic Management of Immediate Complications of Therapeutic Endoscopy, 417David A. Greenwald and Martin L. Freeman Part IV Challenges for the Future, 423 34 Assessing Manpower Needs in Gastroenterology and Digestive Endoscopy: Lessons from the Past and Implications for the Future of Endoscopic Training, 425Mihir S. Wagh and Alan Barkun 35 International Opportunities for Obtaining Endoscopy Training, 434Mostafa Ibrahim, Fabian Emura, Amerah Taleb, Noran Roshdy, Ryan Law, and Todd H. Baron 36 Virtual Tools for Training: The Spectrum of Apps and Virtual Aids for Learning GastrointestinalEndoscopy, 440Gene Ma, Alejandra Domínguez, Roque Saenz, and Sarah McGill 37 Providing Resources and Opportunities for Retraining for Practicing Endoscopists, 443John Petrini and Klaus Mergener 38 Evolving Role of GI Societies and Industry in Training Endoscopists to Perform New Techniques: Supporting the Process and Setting the Standards, 449John A. Martin and Christopher J. Gostout 39 The Importance of Skills Assessment and Recording Personal Outcomes in the Future of Training, 460Peter B. Cotton, Sachin Wani, Roland M. Valori, and Jonathan Cohen Index, 470
£146.25
John Wiley & Sons Inc Cannabis For Dummies
Book SynopsisMake informed decisions about the benefits of using cannabis Pot is hotfor good reason. To date, 30 states have legalized medical marijuana to the tune of nearly $11B in consumer spending. Whether it's to help alleviate symptoms of an illness or for adults to use recreationally, more people every day are turning to marijuana. Cannabis For Dummies presents the science behind the use of this amazingly therapeutic plant. Inside, you'll find the hands-on knowledge and education you need to make an informeddecisionabout your cannabis purchase, as a patient and a consumer. Decide for yourself if marijuana is right for youManage aches and painsGain insight on the effects and possible symptom relief Enjoy both sweet and savory ediblesNavigate the legal requirements If you're curious about cannabis, everything you need to discover its many benefits is a page away! Table of ContentsIntroduction 1 About This Book 1 Foolish Assumptions 2 Icons Used in This Book 3 Beyond the Book 4 Where to Go from Here 4 Part 1: Getting Started with Cannabis 5 Chapter 1: Taking the Nickel Tour 7 Exploring the Basics of Marijuana Consumption 8 Considering medical use 8 Looking into adult recreational use 10 Acknowledging the potential drawbacks 10 Knowing What Makes Cannabis So Special 11 Recognizing the Diversity of Cannabis Strains 13 Buying Cannabis 14 Knowing where and where not to get it 14 Understanding what you’re buying 15 Avoiding rip-offs 16 Exploring Different Consumption Methods 16 Smoking or vaping 16 Edibles 17 Tinctures 17 Topical or transdermal applications 18 Getting Up to Speed on Cannabis Laws 18 Being a Safe and Responsible User 19 Grasping the Basics of Cannabis Production 20 Growing cannabis 20 Harvesting and curing cannabis 21 Creating cannabis, extracts, concentrates and infused products 22 Making Money in the Cannabis Industry 22 Recognizing the challenges 23 Getting a job in the industry 23 Starting your own cannabis business 24 Exploring ancillary business 25 Investing in the industry 25 Chapter 2: Brushing Up on Cannabis Anatomy and Chemistry 27 Getting to Know the Plant from Top to Bottom 27 Examining the structure of the two primary strains 28 Checking out the buds and flowers 28 Taking a peek at the seeds 29 Combing through the trichomes 30 Considering the lesser parts of the plant 31 Taking a Crash Course in Cannabinoid Chemistry 32 Assessing factors impacting individual effects 32 Exploring the endocannabinoid system 33 Getting high with tetrahydrocannabinol (THC) 35 Feeling better with cannabidiol (CBD) without getting high 37 Reaping the sedative effects of cannabinol (CBN) 37 Exploring the potential health benefits of cannabigerol (CBG) 37 Discovering the potential health benefits of cannabigerol (CBG) 38 Using terpenes to anticipate effects 38 Exploring Cannabis Concentrates and Extracts 39 Concentrates 39 Extracts 40 Products made from concentrates and extracts 42 Chapter 3: Steering Clear of Legal Trouble 45 Knowing the Laws: Federal, State, Local and International 46 Keeping abreast of U.S federal law and enforcement 46 Getting up to speed on state laws 48 Considering local laws too 51 Knowing your employer’s rules 52 Researching international laws 52 Knowing Your Limits 54 Age limits 54 Purchase limits 55 Grow limits 55 Dosing limits 56 Driving limits 56 Consumption locations 56 Your own personal consumption limits 57 Avoiding Encounters with Law Enforcement 59 Responding Appropriately in Encounters with Law Enforcement 60 Taking Responsibility as a Parent 61 Chapter 4: Tackling Cannabis Politics and Culture 63 Checking the Nation’s Pulse 64 Acknowledging the drivers of change 64 Recognizing differences in attitudes about medical and recreational use 65 Keeping pace with evolving attitudes 66 Debunking Misconceptions of Cannabis and Users 66 Examining Activism 67 Tuning in to Cannabis Culture 69 Part 2: Buying, Storing, and Using Cannabis 71 Chapter 5: Buying and Storing Cannabis 73 Evaluating Your Vendor Options: Where to Buy 74 Buying from a dispensary 74 Buying cannabis online or over the phone 75 Checking out cannabis “gifting” businesses 77 Steering clear of the black market 77 Making Two Key Decisions 78 Getting Quality Product 79 Buy from a reputable dispensary and be willing to pay more 79 Check for third party testing 79 Stick with trusted strains and brands 80 Read the label 80 Inspect the goods 81 Avoiding Common Cannabis Scams 83 Storing Your Cannabis 84 Chapter 6: Choosing and Visiting a Cannabis Dispensary 85 Choosing a Cannabis Dispensary 86 Comparing medical and recreational dispensaries 86 Finding a reliable and legal place to shop 89 Comparing purchase/delivery/pickup options 92 Visiting a Cannabis Dispensary 95 Knowing what to expect 95 Sizing up the budtender 97 Getting a Medical Marijuana Card 98 Chapter 7: Consuming Cannabis 101 Going Old School: Smoking or Vaping 102 Smoking cannabis 102 Vaping cannabis 110 Dabbing 112 Eating and Drinking Cannabis: Edibles 115 Using Topical and Transdermal Products 117 Using Cannabis Tinctures or Pills 118 Taking Pharmaceutical Preparations 119 Chapter 8: Using Cannabis Safely and Responsibly 121 Recognizing the Health and Safety Risks 122 Checking out undesirable transitory effects 122 Looking ahead to potential long-term complications 123 Making Dosing Decisions 124 Defining your desired experience 125 Considering the chemical composition of products 125 Comparing methods of consumption 129 Accounting for other medications or substances used 130 Examining your body’s biochemistry 131 Considering the environment or setting and your mood or mind-set 132 Keeping Safety in Mind 132 Using cannabis in moderation 133 Making rational decisions 133 Committing to no impaired driving 133 Dealing with Overconsumption 134 Distinguishing overconsumption from overdose 134 Avoiding overconsumption 135 Responding to overconsumption 135 Considering Underage Development 136 Part 3: Reaping the Potential Benefits of Medical Marijuana 139 Chapter 9: Using Marijuana for Medicinal Purposes 141 Understanding the Current and Ongoing Status of Medical Marijuana 142 Choosing Medical Marijuana Products 143 Seeking Symptom Relief for Specific Conditions 145 Acne 146 Addiction 146 Alzheimer’s 147 Amyotrophic lateral sclerosis (ALS) 148 Anxiety 149 Appetite loss 149 Arthritis 150 Asthma 151 Attention deficit hyperactivity disorder (ADHD) 151 Autism spectrum disorders 151 Autoimmune disorders 152 Bipolar disorder 153 Cachexia (Wasting) 153 Cancer 154 Cannabinoid hyperemesis syndrome (CHS) 155 Celiac disease and gluten sensitivity 155 Depression 156 Diabetes 157 Eating disorders 158 Epilepsy 158 Fibromyalgia 159 Gastroesophageal reflux disease (GERD) 159 Glaucoma 160 Hepatitis C 161 HIV/AIDS 161 Huntington’s disease 162 Inflammation 162 Insomnia 163 Irritable bowel syndrome (IBS) 163 Lupus 164 Menopause 165 Migraines and headaches 166 Multiple sclerosis (MS) 166 Nausea and vomiting 167 Pain 167 Parkinson’s disease 168 Post-traumatic stress disorder (PTSD) 168 Restless legs syndrome 169 Schizophrenia/psychosis 170 Sexual dysfunction 170 Skin conditions 171 Sports medicine 172 Tourette syndrome 172 Ulcerative colitis and Crohn’s disease 173 Accounting for Potential Adverse Side Effects 174 Chapter 10: Using Pot for Pets 175 Recognizing the Potential Benefits of Cannabis Treatment 176 Consulting Your Veterinarian First 177 Treating Specific Conditions in Pets 178 Anxiety 178 Appetite loss 178 Cancer 179 Digestion issues 180 Epilepsy/seizures 180 Nausea/vomiting 181 Pain 181 Palliative care 181 Tumors 181 Noting the Potential Adverse Effects of Cannabis on Pets 182 Administering Cannabis to Pets 182 Deciding on a way to administer it 183 Choosing an initial dose 183 Monitoring your pet’s reaction 184 Adjusting the dose 184 Preventing and responding to overconsumption 185 Obtaining Commercial Cannabinoid Products 185 Preparing Your Own Concoctions 186 Part 4: Grasping the Basics of Cannabis Cultivation, Post-Harvest, and Production 187 Chapter 11: Growing Cannabis 189 Wrapping Your Brain Around the Cannabis Growth Cycle 190 Choosing a Cultivation Method 191 Indoor 191 Outdoor 192 Hydroponics 193 Soil 193 Creating a Grow Room for Indoor Cultivation 194 Tackling the initial setup 194 Simulating the desired climate 195 Focusing on air flow 195 Setting up grow lights 198 Deciding on a watering/fertilizing system 201 Using a hydroponics system 202 Keeping your grow room impeccably clean 204 Preparing for Outdoor Cultivation 204 Choosing a site 204 Hardening off your plants 207 Supporting and protecting your plants 207 Prepping Your Soil or Other Grow Medium 208 Planting Seeds or Cuttings 209 Acquiring seeds or cuttings 209 Germinating seeds 211 Planting seedlings 212 Cloning plants 212 Transplanting 214 Keeping Your Plants Healthy 214 Ensuring proper temperature, humidity, and lighting 214 Watering and fertilizing your plants 215 Checking and adjusting the pH 216 Battling common pests 216 Preventing and treating common diseases 217 Pruning your plants 218 Training your plants to maximize yield 218 Prepping Plants for Harvest 221 Stop spraying the foliage 221 Flush your grow medium 222 Cultivating Cannabis in an Industrial Setting: Special Considerations 222 Considering space locations and rules 222 Considering the use of pesticides and nutrients 223 Handling green waste 223 Arranging third party testing 223 Tracking plants from seed to sale 224 Chapter 12: Harvesting and Post-Harvest 225 Deciding When to Harvest: Timing is Everything! 226 Keeping an eye on the trichomes 226 Observing the pistils and stigmas 227 Tracking leaf senescence 228 Find out the strain’s expected time-to-harvest 228 Harvesting Your Plants 228 Weighing and Calculating Your Yield (Dry/Wet Weights) 229 Determining the plant’s wet weight 229 Weighing after bucking or shucking and maybe rough trimming 230 Weighing green waste and wet bud 231 Drying, Curing, and Trimming Flower Post-Harvest 232 Drying your plant or buds 232 Curing dried cannabis 236 Trimming bud 238 Storing your buds 239 Packaging for commercial use 239 Chapter 13: Making Concentrates and Marijuana Infused Products (MIPs) 241 Grasping Concentrate Basics 242 Exploring Different Extraction Methods 242 Non-solvent extraction methods 243 Solvent extraction methods 244 Creating Your Own Concentrates 247 Making kief (dry sift) 247 Making dry sift hash 248 Making bubble hash 248 Making dry ice hash 250 Making rosin 252 Making charas 253 Make your own cannabis butter 253 Make your own tincture 256 Cooking Up Edibles 257 Preparing Tinctures, Lotions, and More 258 Part 5: Getting Down to Business 259 Chapter 14: Starting Your Own Cannabis Business 261 Working with a Federal Schedule I Drug 262 Choosing a Business Type 263 Grower 264 Retailer 264 Manufacturer of infused products (MIP) 265 Processed product brand 267 Profiting from cannabis with an ancillary business 268 Addressing Common Challenges 268 Dealing with money issues 269 Adhering to state and local laws 272 Applying for licenses in other states 276 Staffing for Success 278 Filling key positions 279 Providing the necessary training 281 Getting your people certified: Badging 282 Setting Up Shop 282 Choosing a facility 282 Establishing your supply chain 283 Tackling transportation issues 283 Acquiring the necessary equipment 284 Creating a website/blog 286 Building your point of sale (POS) system 287 Maintaining a Positive Public Image 287 Attending community hearings 288 Handling public affairs 288 Communicating with the press 288 Catering to the customer 289 Chapter 15: Finding Work in the Cannabis Industry 291 Scoping Out Job Opportunities 292 Grow master or grower 292 Cultivation technician 292 Trimmer 293 Joint roller 293 Cure associate 293 Nutrient chemist 293 Extractor 294 Quality assurance manager 294 Dispensary manager 294 Budtender/sales associate 295 Dispensary receptionist or cashier 295 Packager 296 Edibles chef 296 Courier/delivery driver 296 Buyer 297 Sales representatives 297 Compliance manager 298 Communications director 298 Human resources (HR) manager 299 Trainers 299 Public affairs administrator 300 Laboratory worker 300 Security manager or officer 300 Accountant 301 Marketing manager or team members 301 Facilities manager 301 Technology manager 302 Exploring Jobs in Ancillary Industries and Professions 302 Finding Employers 303 Improving Your Odds of Getting Hired 304 Brush up on cannabis culture and law 304 Attend industry events 305 Get your cannabis badge or state clearance 305 Become a cannabis activist 306 Chapter 16: Investing in Cannabis 307 Sizing Up Current and Future Investment Opportunities 308 Considering the current market 308 Exploring publicly traded stock on the Canadian market 310 Looking ahead to the future market 312 Performing Your Due Diligence 312 Seeking Private Investment Opportunities 313 Considering Investments in Ancillary Businesses 314 Investing in Cannabis Real Estate 314 Part 6: The Part of Tens 317 Chapter 17: Ten Tips for Growing More and Better Weed 319 Choose the Right Strain 319 Choose Top-Quality Seeds 321 Use High-Quality Soil 321 Upsize Your Containers 321 Maximize Bud Production with Topping, Training, and Scrogging 322 Use the Right Nutrients in the Right Amounts at the Right Times 323 Get the Lighting Right 323 Ensure Proper Ventilation and Circulation 324 Be Patient Near Harvest Time 325 Dry and Cure Your Weed Properly 325 Chapter 18: Ten Tips to Enhance Your Cannabis Experience 327 Choose Top-Quality Products 327 Experiment with Different Strains 328 Try Different Consumption Methods 328 Try Hash and Other Concentrates 329 Set the Mood 329 Chill Your Bong 330 Boost Your High with Certain Foods 330 Exercise Regularly 331 Break the Monotony 331 Take a Tolerance Break 331 Chapter 19: Ten Tips for Buying Cannabis 333 Choose the Right Dispensary for You 333 Find a Knowledgeable and Helpful Budtender 334 Describe the Specific Effect You Desire 335 Buy Legal Cannabis 335 Visually Inspect the Product 336 Smell It 336 “Feel” It 337 Taste It 337 Ask About the Cultivation Method 338 Compare Prices 338 Appendix: Cannabis Recipes 339 Index 361
£18.69
John Wiley and Sons Ltd Clinical Pancreatology for Practising
Book SynopsisClinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines.A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development ofTable of ContentsContributors xxxiii Foreword xlvi Preface xlvii Dedication xlviii Section I Acute Pancreatitis 1 1 Acute Pancreatitis: An Overview 3Jodie A. Barkin and Jamie S. Barkin 2 How to Deal with the Etiological Diagnosis of Acute Pancreatitis in Clinical Practice? 17Soumya Jagannath and Pramod Kumar Garg 3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice 25David X. Jin, Peter A. Banks, and Julia McNabb-Baltar 4 Early Prediction of Severity in Acute Pancreatitis: What can be Done in Clinical Practice? 31Peter J. Lee and Georgios I. Papachristou 5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 40Elham Afghani, Mahya Faghih, and Vikesh K. Singh 6 Role of MRI in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 47Fatih Akisik 7 Treatment of Acute Pancreatitis in The Emergency Room: What Should be Done During the First Hours of Disease? 53Thiruvengadam Muniraj and Santhi Swaroop Vege 8 Acute Pancreatitis: A Practical Guideline for the Monitoring and Treatment of Systemic Complications 59Enrique de Madaria and Felix Zubia-Olaskoaga 9 Guidelines for the Treatment of Pain in Acute Pancreatitis 66László Czakó 10 Nutrition in the Acute Phase of Pancreatitis: Why, When, How and How Long? 72Angela Pham and Chris E. Forsmark 11 Oral Refeeding in Acute Pancreatitis: When and How Should it be Restarted? 78José Lariño-Noia and Daniel de la Iglesia-García 12 Pharmacological Therapy for Acute Pancreatitis: Any Light at the End of the Tunnel? 83Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, and Robert Sutton 13 Indication and Optimal Timing of ERCP in Acute Pancreatitis 95Theodor Voiosu, Ivo Boškoski, and Guido Costamagna 14 How to Deal with Infected Pancreatic Necrosis? 100J. Enrique Domínguez-Muñoz 15 Minimally Invasive Surgical Necrosectomy in Clinical Practice: Indications, Technical Issues, and Optimal Timing 105Patricia Sánchez-Velázquez, Fernando Burdío, and Ignasi Poves† 16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical Issues and Optimal Timing 113Jodie A. Barkin and Andres Gelrud 17 Management of Acute Pancreatic Pseudocyst: When to Observe, When and How to Drain? 120Muhammad F. Dawwas and Kofi W. Oppong 18 The Disconnected Main Pancreatic Duct Syndrome: How to Proceed in Clinical Practice? 126Mario Peláez-Luna, Andrea Soriano-Ríos, and Luis Uscanga-Dominguez 19 Vasculature Complications in Pancreatitis: How to Deal with Them? 132Daniel G. McCall and Timothy B. Gardner 20 Acute Relapsing Pancreatitis: What can be Done to Prevent Relapses? 141Jorge D. Machicado and Dhiraj Yadav 21 Diagnosis and Therapeutic Approach to Pancreatic Exocrine Insufficiency after Acute Pancreatitis 151Hester C. Timmerhuis, Christa J. Sperna Weiland, and Hjalmar C. van Santvoort 22 Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes: How to Deal with It? 158Giuseppe Vanella, Paolo Giorgio Arcidiacono, and Gabriele Capurso Section II Chronic Pancreatitis 169 23 Definition and Etiology of Chronic Pancreatitis: What is Relevant for Clinical Practice? 171David C. Whitcomb 24 Epidemiology of Chronic Pancreatitis: An Infrequent Disease or an Infrequently Diagnosed Disease? 180Philippe Lévy and Vinciane Rebours 25 Alcoholic Chronic Pancreatitis and the Impact of Alcohol and Smoking Cessation in Chronic Pancreatitis 185Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte 26 What is Relevant on Genetics in Chronic Pancreatitis for Clinical Practice? What Genes and When to Evaluate Them? 193Jonas Rosendahl 27 Pancreas Divisum and Other Potential Obstructive Causes of Chronic Pancreatitis: When and How to Treat Them? 198Matthew J. DiMagno and Erik-Jan Wamsteker 28 What to do in Clinical Practice Before Defining a Chronic Pancreatitis as Idiopathic? A Practical Protocol 208Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch 29 Computed Tomography for the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 218Roberto García-Figueiras, Sandra Baleato-González, and Gonzalo Tardáguila de la Fuente 30 Role of MRI and MRCP in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 227Jordan K. Swensson and Temel Tirkes 31 Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 233Julio Iglesias-Garcia 32 Endoscopic Pancreatic Function Test for the Functional Diagnosis of Chronic Pancreatitis: Indications and Practical Protocol 243Luis F. Lara and Darwin L. Conwell 33 Role of Pancreatic Function Tests for the Diagnosis of Chronic Pancreatitis: Which Tests and How Should they be Performed in Clinical Practice? 250J. Enrique Domínguez-Muñoz 34 Follow-up of Patients with Chronic Pancreatitis in Clinical Practice: How and What for? 255Antonio Mendoza-Ladd, Luis F. Lara, and Darwin L. Conwell 35 Quality of Life in Chronic Pancreatitis 265Colin D. Johnson 36 Medical Treatment of Pain in Chronic Pancreatitis: Guidelines for Clinical Practice 273Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen, and Søren Schou Olesen 37 Endoscopic Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing, and Technical Aspects 283Pauline M. C. Stassen, Pieter J. F. de Jonge, Jan-Werner Poley, Djuna L. Cahen, and Marco .J. Bruno 38 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Chronic Pancreatitis: A Practical Protocol 292J. Enrique Domínguez-Muñoz 39 Surgical Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing and Technical Approaches 301Benjamin P.T. Loveday and John A. Windsor 40 Management of Chronic Pancreatic Pseudocyst: When to Observe, When and How to Drain? 314Shyam Varadarajulu 41 Vascular Complications in Chronic Pancreatitis 322Anil K. Agarwal, Raja Kalayarasan, and Amit Javed 42 Surgical Therapy of Local Complications of Chronic Pancreatitis: Indications, Technical Approaches, and Optimal Timing 333Ricardo Arvizu Castillo, Elena Muñoz-Forner, and Luis Sabater 43 Endoscopic Treatment of Complications of Chronic Pancreatitis other than Pseudocyst 342Jahangeer Basha, Rupjyoti Talukdar, and D. Nageshwar Reddy Section III Autoimmune Pancreatitis 347 44 Autoimmune Pancreatitis: Definition, Clinical Presentation, and Classification 349Miroslav Vujasinovic and J. -Matthias Löhr 45 Diagnosis of Autoimmune Pancreatitis: A Protocol for Clinical Practice 356Nicolò de Pretis, Antonio Amodio, and Luca Frulloni 46 Treatment and Follow-up of Autoimmune Pancreatitis in Clinical Practice 360Sushil Kumar Garg and Suresh T. Chari Section IV Cystic Fibrosis (CFTR)-associated Pancreatic Disease 369 47 CFTR-associated Pancreatic Disease: Genotype–Phenotype Correlations and Impact of CFTR-modifying Therapy 371Aimee Joy Wiseman and Chee Y. Ooi 48 Nutritional Therapy, Pancreatic Exocrine Insufficiency, and Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis: a Protocol for Clinical Practice 379Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, and Asim Maqbool Section V Pancreatic Cancer 389 49 Epidemiological Impact of Pancreatic Cancer 391Patrick Maisonneuve 50 Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts are Clinically Relevant? 404Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, and Helmut Friess 51 New-onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible? 409Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, and Stephen J. Pandol 52 Pancreatic Cancer Screening: Target Populations, Methods, and Protocols for Clinical Practice 418Christopher Paiji, Anne Marie Lennon, and Elham Afghani 53 Clinical Usefulness of Biological Markers in Pancreatic Cancer 425David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, and Julia Mayerle 54 Staging Classification and Stratification of Pancreatic Cancer for Clinical Practice 433Akhil Chawla and Andrew J. Aguirre 55 Imaging Diagnosis and Staging of Pancreatic Cancer: Which Methods are Essential and What Information Should they Provide? 443Megan H. Lee and Elliot K. Fishman 56 The Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis and Assessment of Resectability of Pancreatic Cancer 449Marc. Giovannini 57 EUS-Guided FNA/FNB for Pancreatic Solid Lesions: When is it Indicated and What is the Optimal Technical Approach? 460Mihai Rimbaș, Gianenrico Rizzatti, and Alberto Larghi 58 Surgical Treatment of Resectable Pancreatic Cancer: What is the Optimal Strategy? 472Jan G. D’Haese, Bernhard W. Renz, and Jens Werner 59 Complications After Pancreatic Surgery: How to Deal with Them? 477Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi 60 Neoadjuvant Treatment of Pancreatic Cancer: When and How? 488Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, and John P. Neoptolemos 61 Adjuvant Therapy in Pancreatic Cancer: Options, Safety, and Outcomes 501Jean-Luc Van Laethem 62 Management of Pain in Pancreatic Cancer: An Algorithm for Clinical Routine 506J. Enrique Domínguez-Muñoz 63 EUS-guided Celiac Plexus Neurolysis for Pain in Pancreatic Cancer: When and How? 514Jonathan M. Wyse and Anand V. Sahai 64 The Role of Endoscopy in the Management of Unresectable Pancreatic Cancer 520Jaimin P. Amin, Ajaypal Singh, and Irving Waxman 65 Chemotherapy for Nonresectable Pancreatic Cancer 530Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, and Alfredo Carrato 66 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Pancreatic Cancer 538Sarah Powell-Brett and Keith J. Roberts 67 Nutrition and Pancreatic Cancer 548Mary Phillips and Oonagh Griffin 68 Present and Future of Local Therapies for Unresectable Pancreatic Cancer 555Sabrina Gloria Giulia Testoni, Gemma Rossi, Livia Archibugi, and Paolo Giorgio Arcidiacono 69 New Pharmacological Approaches for Pancreatic Cancer Therapy: A Light at the End of the Tunnel? 564Vineet K. Gupta, Sulagna Banerjee, and Ashok K. Saluja Section VI Cystic Tumors of the Pancreas 573 70 Histological Classification of Pancreatic Cystic Neoplasms 575Giuseppe Zamboni and Anna Pesci 71 Role of Endoscopic Ultrasound and Endoscopic Ultrasound-associated Techniques in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Tumors 584María-Victoria Alvarez-Sánchez and Bertrand Napoléon 72 The Role of Multidetector CT, MRI and MRCP in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Neoplasms 593Megan H. Lee and Elliot K. Fishman 73 Intraductal Papillary Mucinous Neoplasm: When to Observe, When to Operate, and Optimal Surgical Approach 599Zhi Ven Fong and Carlos Fernandez-del Castillo 74 Cystic Tumors Other than IPMN: When to Observe, When to Operate, and Optimal Surgical Approach 608John W. Kunstman, and James J. Farrell 75 Pancreatic Cystic Tumors: any Role for Local Therapies? 624Julio Iglesias-Garcia Section VII Neuroendocrine and Other Tumors of the Pancreas 631 76 Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors: How to Deal with them in Clinical Practice? 633Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi 77 Other less Frequent Pancreatic Tumors: What Should be Known about Clinical Features, Diagnosis and Treatment? 641Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano, and Tommaso Grottola Section VIII Functional Alterations of the Pancreas in Other Clinical Situations 651 78 Diagnosis and Therapy of Exocrine Pancreatic Insufficiency after Gastric and Pancreatic Surgery 653Raffaele Pezzilli 79 Pancreatic Exocrine Insufficiency in Type 1 and Type 2 Diabetes Mellitus: Lessons from Pancreatologists toDiabetologists 662Philip D. Hardt 80 Diabetes Mellitus Related to Diseases of the Exocrine Pancreas (Pancreatogenic Diabetes): Diagnosis and Treatment 668David A. Bradley and Phil A. Hart Index 679
£197.96
John Wiley and Sons Ltd Basic Guide to Orthodontic Dental Nursing
Book SynopsisAn updated second edition of the essential reference for any dental nurse undertaking the NEBDN qualification in Orthodontic Dental Nursing The revised second edition of Basic Guide to Orthodontic Dental Nursing is a comprehensive guide that offers an introduction for students seeking to develop their knowledge and understanding of this core area of clinical practice. Written in a clear and accessible format, it covers key subjects such as tooth eruption patterns, removable and fixed appliances, de-bonding and retention. It also contains information on care prior to treatment including the requirements for a first appointment and a helpful guide on maintaining motivation particularly for young patients and their parents. Presents essential information on orthodontic dental nursing Is written for trainee dental nurses undertaking the National Examining Board for Dental Nurses (NEBDN) qualification in Orthodontic Dental Nursing Trade Review'This book is a nice introduction to orthodontic nursing for any dental nurse who may work with a dentist with an interest in orthodontics or perhaps assisting an orthodontic therapist'.BDJ Team 7, 6 (2020)Table of ContentsForeword to Second Edition ix How to use this book xi Acknowledgements xiii 1 Definition of orthodontics and factors influencing orthodontic treatment 1 2 The first appointment 13 3 Occlusal indices 35 4 Motivation 45 5 Leaflets 53 6 Oral hygiene 59 7 Removable appliances 71 8 Transpalatal arches, lingual arches and quad helix 85 9 Rapid maxillary expansion 93 10 Headgear 101 11 Functional appliances 109 12 Temporary anchorage devices and magnets 119 13 Fixed appliances: what they do and what is used 127 14 Fixed appliances: direct bonding 161 15 Fixed appliances: indirect bonding and lingual orthodontics 177 16 Ectopic canines 187 17 Debonding 197 18 Retention and retainers 203 19 Aligners 215 20 Multi-disciplinary orthodontics 225 21 Adult orthodontics 241 22 Mandibular advancement devices 249 23 Study models and digital storage of records 259 24 Descriptions and photographs of the most commonly used instruments and auxiliaries 267 25 Certificate in Orthodontic Nursing, extended duties and ongoing training 295 26 Orthodontic therapists 305 27 The Orthodontic National Group for Dental Nurses and Therapists 311 Useful contacts 315 Glossary 319 Index 327
£46.50
John Wiley and Sons Ltd Health Communication Theory
Book SynopsisTable of Contents Part I: Perspectives on the Field of Health Communication Ch. 1: Basics of Health Communication Theory Teresa Thompson and James D. Robinson Ch. 2: Segmenting Priority Audiences Employing Individual Difference Variables to Improve Health Promotion Efforts Brian Quick, Tobias Reynolds-Tylus, Salah H. Al-Ghaithi, and Michael Mackert Ch. 3: When Theory and Methods Intertwine Jill Yamasaki Part II: Perspectives on Dyads and Groups Ch. 4: Interpersonal Health Communication Theories Maria Brann, Jennifer Bute, Maureen Keeley, Sandra Petronio, Rachyl Pines, and Bernadette Watson Ch. 5: Families Interacting in the Health Care Context Maureen Keeley and Hannah Jones Ch. 6: Theoretical Frameworks of Provider-Patient Interaction Peter J. Schulz and Shaohai Jiang Part III: Perspectives on Influence Processes Ch. 7: Information-Processing and Cognitive Theories Monique Mitchell Turner, Youjin Jang, and Shawn Turner Ch. 8: Theories of Affective Impact Robin Nabi Ch. 9: Theories of Behavior Marco Yzer and Rebekah Nagler Ch. 10: Theories of Message Effects James Robinson, Yan Tian, and Jeanine Warisse-Turner Part IV: Perspectives on Organisations and Society Ch. 11: Social Psychological Influences on Health Communication: An Examination of Four Theories Yanqin Liu and Anthony Roberto Ch. 12: Theories of Public Relations Arunima Krishna Ch. 13: Theories of Uncertainty Austin S. Babrow, Marianne S. Matthias, Sarah M. Parsloe, and Anne M. Stone Ch. 14: Cultural Theories of Health Communication Evelyn Ho and Barbara Sharf Ch. 15: Effects of Digital Media Technology on Health Communication Shyam Sundar and Maria D. Molinar Part V: Perspectives on the Future Ch. 16: Directions in Health Communication Theory Dannielle Kelley and Brian Southwell
£39.85
John Wiley and Sons Ltd Essential Guide to Acute Care
Book SynopsisWhat you really need to know, but no-one told you. The best-selling Essential Guide to Acute Care contains everything you need to know about acute care that you can''t find in a standard textbook. The third edition has been extensively revised and updated, presenting new oxygen guidelines, updated evidence and practice around sepsis, fluid balance and volume resuscitation, acute kidney injury, perioperative care, and much more. The third edition retains the accessible style and comprehensive coverage that has made Essential Guide to Acute Care essential reading for those who look after acutely ill adults. Throughout the book, ''mini-tutorials'' expand on the latest thinking or controversies, and there are practical case histories to reinforce learning at the end of each chapter. The chapters are designed to be read by individuals or used for teaching material in tutorials. This new edition of Essential Guide to Acute Care: Table of ContentsReviews of the Second Edition vii Introduction ix Acknowledgements xi Foreword to the Second Edition xiii Units Used in This Book xv List of Abbreviations xvii 1 Patients at Risk 1 2 Oxygen Therapy 13 3 Acid–Base Balance 35 4 Respiratory Failure 49 5 Fluid Balance and Volume Resuscitation 77 6 Sepsis 101 7 Acute Kidney Injury 129 8 Brain Injury 149 9 Optimising Patients Before Surgery 167 10 Pain Control and Sedation 193 Index 205
£36.05
John Wiley & Sons Inc Skin Microbiome Handbook
Book SynopsisThe book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome andTable of ContentsPreface xvii Part 1: Healthy Skin Microbiome and Oral-Skin Interactions 1 1 The Microbiome of Healthy Skin 3Samantha Samaras and Michael Hoptroff 1.1 Introduction 3 1.1.1 Retrospective 3 1.1.2 Next Generation Sequencing 6 1.2 The Skin Microbiome in Health 7 1.2.1 Composition 7 1.2.2 Diversity 10 1.2.3 Uniqueness 13 1.3 Healthy Skin is the Foundation of a Balanced Skin Microbiome 14 1.3.1 Physical Aspects of Skin Impacting the Microbiome 14 1.3.2 Biochemical and Defensive Aspects of Skin Impacting the Microbiome 16 1.3.2.1 The Acid Mantle 16 1.3.2.2 Antimicrobial Lipids (AMLs) 16 1.3.2.3 Antimicrobial Peptides (AMPs) 17 1.3.3 Nutritional and Microenvironmental Aspects of Skin Impacting the Microbiome 18 1.3.3.1 Amino Acids 18 1.3.3.2 Sebaceous Lipids 19 1.3.3.3 Organic Acids and Other Materials 19 1.4 A Balanced Skin Microbiome Supports the Normal Functioning of Healthy Skin 20 1.4.1 Pathogen Exclusion 20 1.4.2 Contribution to Skin pH 20 1.4.3 Microbial Contribution to Skin Barrier Integrity 21 1.5 Conclusion 22 Acknowledgments 23 References 23 2 The Gut Microbiome-Skin Axis: Impact on Skin and Systemic Health 33David Drake 2.1 Introduction 34 2.2 The Gut-Skin Microbiome Axis 35 2.3 The Gut-Skin Microbiome Axis: Principle Pathways 35 2.4 Dysbiosis of the Gut Microbiome and Skin Dyshomeostasis 37 2.4.1 Acne Vulgaris 38 2.4.2 Atopic Dermatitis 39 2.5 Summary and Future Directions 39 References 40 3 The Skin and Oral Microbiome: An Examination of Overlap and Potential Interactions between Microbiome Communities 45Sandra Buerger 3.1 Introduction 45 3.1.1 Focus of the Chapter 45 3.1.2 Definition of Skin Microbiome 47 3.1.3 Definition of Oral Microbiome 48 3.2 Characterization of the Microbiome 48 3.2.1 Variability and Stability of Skin and Oral Microbiome 48 3.2.2 Microbial Community 49 3.2.2.1 Permeant Mutualistic or Commensal Microbes 49 3.2.2.2 Non-Pathogenic Transient Microbes 50 3.2.2.3 Pathogenic Microbes 50 3.3 The Core Skin and Oral Microbiomes 51 3.3.1 Taxonomic Methodology 51 3.3.2 Subgroups of the Microbiome 52 3.3.2.1 Bacteriome 52 3.3.2.2 Mycobiome (and Other Eukaryotic Microbial Members) 52 3.3.2.3 Virome 53 3.4 Interactions Between Skin and Oral Microbiomes 54 3.4.1 Potential for Interactions 54 3.4.2 Quorum Sensing 54 3.4.3 Immune System Development 54 3.4.4 Future Directions 55 3.5 Conclusion 55 Acknowledgments 56 References 56 Part 2: Skin Microbiome Observational Research 59 4 Skin Microbiome Alterations in Skin Diseases 61Travis Whitfill, Gilles R. Dubé and Julia Oh 4.1 Introduction and Background 61 4.2 Interactions Between Microbes and Host 62 4.3 Summary of Known Associations Between Skin Dysbioses and Skin Diseases 64 4.3.1 The Role of S. Aureus in Skin Disease 64 4.3.2 Atopic Dermatitis 64 4.3.3 Acne Vulgaris 66 4.3.4 Psoriasis 67 4.4 Skin Dysbioses in Skin Health 68 4.5 Other Skin Conditions 68 4.6 Therapeutic Approaches to Dysbiosis-Associated Skin Diseases 69 4.6.1 Traditional Methods of Treating Dysbiosis-Associated Skin Diseases 69 4.6.1.1 Atopic Dermatitis 69 4.6.1.2 Acne Vulgaris 69 4.6.2 Emerging Therapeutic Approaches to Treating Dysbiosis-Associated Skin Diseases 70 4.7 Conclusion and Future Directions 71 Acknowledgements 71 References 71 5 The Axillary Microbiome and its Relationship with Underarm Odor 79Alexander Gordon James 5.1 Introduction 80 5.2 Composition of the Axillary Microbiome 86 5.3 16-Androstene Steroids and Axillary Malodour 95 5.4 The Axillary Microbiome, VFAs and Malodour 96 5.5 The Axillary Microbiome, Thioalcohols and Malodour 100 5.6 Perturbation of the Axillary Microbiome 108 5.7 Human Genetics – Influence on Malodour and the Axillary Microbiome 112 5.8 Conclusions and Future Perspectives 115 Acknowledgements 122 References 122 6 Infant Skin Microbiome 131Georgios N. Stamatas 6.1 Introduction 131 6.2 Infant Skin Maturation 132 6.3 Infant Immune System Maturation 133 6.4 Infant Skin Microbiome Dynamics 134 6.5 Mother-Infant Microbial Transmission 137 6.6 Conclusion 138 References 139 Part 3: Skin Microbiome in Disequilibrium and Disease 143 7 Microbiome of Compromised Skin 145Sara Farahmand 7.1 Atopic Dermatitis 146 7.2 Psoriasis 148 7.2.1 Diversity 149 7.2.2 Microbiome Composition 151 7.3 Acne 152 7.4 Rosacea 153 7.5 Seborrheic Dermatitis and Dandruff 155 7.6 Exposome, Skin Barrier, and Skin Microbiome 157 7.6.1 Skin Irritation and Microbiome 157 7.6.2 Diaper Dermatitis 157 7.6.3 Occupational Hand Dermatitis 158 7.6.4 Allergic Contact Dermatitis (ACD) and Skin Microbiome 159 7.7 Conclusion 160 References 163 8 Human Cutaneous Ectoparasites: A Brief Overview and Potential Therapeutic Role for Demodex 171Stephen L. Strobel 8.1 Introduction 171 8.2 Chiggers (Trombiculidae) 172 8.3 Bedbugs (Cimex lectularius and Hemipterus) 173 8.4 Lice 173 8.5 Scabies (Sarcoptes scabiei) 174 8.6 Demodex 175 8.7 The Association Between Demodex, Rosacea and Blepharitis 176 8.8 Hypothesis 177 8.9 Demodex Folliculorum as a Drug Delivery Agent for Early Skin Cancer 177 8.10 Limitations 179 8.11 Conclusion 180 8.12 Future Considerations 181 References 182 9 Dysbiosis of the Skin Microbiome in Atopic Dermatitis 185Joyce Cheng and Tissa Hata 9.1 Introduction 185 9.2 The Healthy Skin Microbiome 186 9.3 The Skin Microbiome in Atopic Dermatitis 187 9.4 Microbiome-Targeted Treatment Strategies 195 9.5 Conclusion 196 References 196 10 The Skin Microbiome of Inverse Psoriasis 203Jennifer Chung, Bruce E. Strober and George M. Weinstock 10.1 Introduction 204 10.2 Methods 205 10.2.1 Subject Population 205 10.2.2 Patient Diagnosis and Characteristics of Populations 206 10.2.3 Specimen Collection 206 10.2.4 Sample DNA Extraction and Sequencing 207 10.2.5 Downstream Sequence Processing and Analysis 207 10.3 Results 208 10.3.1 Cohort Metadata 208 10.3.2 Sequencing Information 208 10.3.3 The Skin Microbiome of Intertriginous Lesion and Non-Lesional Sites on Inverse Psoriasis Subjects 208 10.3.3.1 Psoriasis Lesional Status is Associated with Relative Abundance and Presence of Specific Species 208 10.3.3.2 Psoriatic Lesions Trend to Decrease Taxonomic Diversity 210 10.3.3.3 Psoriatic Lesions are Characterized by Greater Intragroup Variability 212 10.3.4 Inverse Psoriasis vs. Plaque Psoriasis vs. Healthy (All Non-Lesion Sites) 212 10.4 Conclusions & Future Plans 212 Acknowledgements 213 References 214 Part 4: Skin’s Innate Immunity 217 11 Effects of Endogenous Lipids on the Skin Microbiome 219Carol L. Fischer and Philip W. Wertz 11.1 Introduction 219 11.2 Sebaceous Lipids -- Source of Fatty Acids 221 11.3 Stratum Corneum Lipids – Source of Long-Chain Bases 223 11.4 Antimicrobial Activity of Fatty Acids 226 11.5 Antimicrobial Activity of Long-Chain Bases 230 11.6 Conclusion 231 References 231 12 Innate Immunity in Epidermis 237Miroslav Blumenberg 12.1 Introduction 237 12.2 Skin Acts as an Anatomical Physical and Chemical Barrier to Infectious Agents 238 12.3 Epidermal Cells Recognize Conserved Features of Pathogens, as well as the Indicators of Tissue Damage 239 12.4 Defensive Antimicrobial Proteins AMPs 240 12.5 Cytokines, Specific Signals that Activate Inflammation and Further Cellular Protective Mechanisms 242 12.6 Specialized White Blood Cells Identify and Remove Pathogens 243 12.7 Complement System 246 12.8 Innate Immune System Activates the Adaptive Immune System 246 12.9 Antiviral Defenses 247 12.10 Innate Immunity Memory? 247 12.11 Cutaneous Microbiome: A Newly Surfaced Contributor to Innate Immunity 248 12.12 Conclusion 251 12.13 Future Perspectives 252 References 254 Part 5: Testing and Study Design 261 13 Next Generation Sequencing Reveals the Skin Microbiome 263Niamh B O’Hara 13.1 Introduction 263 13.2 Current Approaches to Test the Microbiome 265 13.3 The Genomics Revolution and Metagenomics 266 13.4 Metagenomics and the Skin Microbiome 267 13.5 Our Work at Biotia 268 13.6 Challenges and Solutions in Metagenomics 269 13.7 The Microbial World is our Oyster 272 13.8 The Future of Metagenomics 273 Acknowledgements 273 References 274 14 Three-Dimensional Human Skin Models to Investigate Skin Innate and Immune-Mediated Responses to Microorganisms 277Marisa Meloni and Silvia Balzaretti 14.1 State-of-the-Art and Limits of Skin Microbiota Research 277 14.2 Mechanism-Based Approach to Study Host Response to Associated Microbiome: 3D Skin Models 279 14.3 Understanding S. epidermidis and S. aureus Behavior and Role on Reconstructed Human Epidermis (RHE) 281 14.4 Immuno-Competent Atopic Dermatitis Model 284 14.5 Conclusion and Future Perspectives 286 References 286 15 Cutibacterium acnes (formerly Propionibacterium acnes) In-Vivo Reduction Assay: A Pre-Clinical Pharmacodynamic Assay for Evaluating Antimicrobial/Antibiotic Agents in Development for Acne Treatment 289Stuart R. Lessin and James J. Leyden 15.1 Acne Pathogenesis and the Role of Cutibacterium acnes (formerly Propionibacterium acnes) 290 15.1.1 Introduction 290 15.1.2 Pathogenesis 290 15.1.3 The Role of C. acnes and its Microbiome 290 15.2 Current Therapies and Regulatory Approval 293 15.3 In-Vivo C. acnes Reduction Assay 294 15.4 Correlations of C. acnes Reduction and Clinical Efficacy 297 15.5 Conclusion 300 References 300 Part 6: Regulatory and Legal Aspects for Skin Microbiome Related Products 303 16 Intellectual Property Tools for Protecting, Developing and Growing a Skin Microbiome Brand 305Jeffrey K. Mills 16.1 Introduction 305 16.2 The Tools of Intellectual Property 306 16.2.1 Patents 306 16.2.2 Trademarks 307 16.2.3 Copyrights 308 16.2.4 Trade Secrets/Know-How 309 16.3 Building an Intellectual Property Portfolio for a Skin Microbiome Brand 310 16.3.1 Patents to Define “The Fence” 310 16.3.1.1 Patents “As Sticks” – Enforcement of Infringement 313 16.3.1.2 Patents “As Financial Boosts” – Licensing and Other Agreements 314 16.3.2 Trademarks to Establish Brand Recognition 315 16.3.3 Copyrights to Maintain Information 317 16.3.4 Trade Secrets/Know-How to Keep A Competitive Edge 318 16.4 Conclusion 320 17 Regulatory Aspects of Probiotics and Other Microbial Products Intended for Skin Care: The European Approach 321Atte von Wright 17.1 Introduction 322 17.2 The Governing Bodies and Decision-Making in the EU 322 17.2.1 The Legal Instruments of the EU 323 17.3 Probiotic Foods and the European Regulations 324 17.3.1 The Safety Assessment of Microorganisms by EFSA, The QPS Concept 324 17.3.1.1 The Safety Assessment of Non-QPS Microorganisms 327 17.3.2 The Case of GMMs 328 17.3.3 Microorganisms as Novel Foods 329 17.3.4 Human Probiotics and Functional Claims 329 17.4 Probiotic Skin Care Products as Pharmaceuticals 330 17.4.1 The Authorization Procedure for Medicines 331 17.4.1.1 The Centralized Procedure 332 17.4.1.2 National Authorizations and Authorizations by Mutual Recognition or Decentralized Procedures 333 17.4.2 Bacteria as Medical Devices 334 17.5 Probiotics in Cosmetics 335 17.5.1 Safety Aspects 336 17.5.1.1 Microorganisms on Skin – Problems of Safety Evaluation 337 17.5.2 The Permissible Cosmetic Claims in the EU 338 17.6 Conclusions 338 References 340 Legal Acts and Guidance Documents 340 18 Regulation of Probiotic and Other Live Biologic Products: The United States Approach 343Ronie M. Schmelz 18.1 Introduction 343 18.1.1 U.S. Legislative Landscape 344 18.1.2 Foods 345 18.1.2.1 Permissible Food Claims 350 18.1.2.2 Additional Regulatory Considerations 354 18.1.3 Dietary Supplements 355 18.1.3.1 Permissible Dietary Supplement Claims 357 18.1.3.2 Additional Regulatory Considerations 359 18.1.4 Drugs 360 18.1.4.1 Drug Approval Process 361 18.1.4.2 Additional Regulatory Considerations 364 18.1.5 Cosmetics 364 18.2 Summary of Product Categorization and Regulatory Requirements 365 18.3 Resources 369 18.4 Endnotes 369 19 A Future Research Perspective Is There a Connection Between Sun Exposure, Microbiome and Skin Cancer? 377Nava Dayan 19.1 Introduction 378 19.2 Ultraviolet Light (UV) – The Skin Microbiome and Cancer 378 19.3 Conclusion 386 Acknowledgment 386 References 387 Glossary 389 Index 399
£161.06
John Wiley and Sons Ltd The Handbook of Language and Speech Disorders
Book SynopsisAn authoritative overview of language and speech disorders, featuring new and updated chapters written by leading specialists from across the field The Handbook of Speech and Language Disorders, Second Edition, provides timely and authoritative coverage of current issues, foundational principles, and new research directions within the study of communication disorders. Building upon the reputation of the landmark first edition, this volume offers an exceptionally broad and in-depth survey of the field, presenting original chapters by internationally recognized specialists that examine an array of language, speech, and cognitive disorders and discuss the most crucial aspects of this evolving discipline while providing practical information on analytical methods and assessment. Now in its second edition, the Handbook features extensively revised and refocused content throughout, reflecting the latest advances in the field. Original and updated chapters exploTrade Review“This kind of volume, one that brings together knowledge from different specialists and perspectives, is not just necessary but essential in order to develop a better understanding of the disorders and to improve the treatments and their positive outcomes.” – LINGUIST List 33.1511, April 2022Table of ContentsList of Figures vii Notes on Contributors ix Introduction 1Jack S. Damico, Nicole Müller, and Martin J. Ball Part I Foundations 5 1 Labeling as a Sociocultural Process in Communicative Disorders 7Jack S. Damico, Nicole Müller, and Martin J. Ball 2 Diversity Considerations in Speech and Language Disorders: A Focus on Training 33Elena Babatsouli 3 Hearing Loss and Cochlear Implants 53David Jackson Morris and Daan Van de Velde 4 Intelligibility Impairment 81Katherine C. Hustad and Stephanie A. Borrie 5 Genetic Syndromes and Communication Disorders 95Vesna Stojanovik 6 Principles of Assessment and Intervention 110Bonnie Brinton, Martin Fujiki, and Robert Brinton Fujiki Part II Language Disorders 129 7 Autism Spectrum Disorders 131Patricia A. Prelock 8 Language Acquisition and Language Delay 152Paul Fletcher 9 Developmental Language Disorder 171Sandra L. Gillam, Sarai Holbrook, and Alan G. Kamhi 10 Pragmatic Impairment 192Louise Cummings 11 Learning Disabilities 209Christine Brennan 12 Literacy and Literacy Impairments 237Holly Damico, Jack S. Damico, and Ryan Nelson 13 Language and Literacy in the Context of Early Life Adversity 266Pamela Snow, Suze Leitão, and Natalie Kippin 14 Aphasia 286Chris Code Part III Speech Disorders 311 15 Children with Speech Sound Disorders 313Susan Rvachew 16 Dysarthria 334Ingo Hertrich, Hermann Ackermann, and Wolfram Ziegler 17 Apraxia of Speech 368Adam Jacks and Katarina L. Haley 18 Augmentative and Alternative Communication: An Introduction 391Kathryn D. R. Drager, Erinn H. Finke, and Elizabeth C. Serpentine 19 Fluency and Fluency Disorders 414John A. Tetnowski, Kathleen Scaler Scott, and Brittany Falcon Rutland 20 Describing, Assessing, and Treating Voice Disorders 445Richard J. Morris and Archie B. Harmon 21 Speech Disorders Related to Cleft Palate and Velopharyngeal Dysfunction 468Debbie Sell, Valerie Pereira, Yvonne Wren, and Jane Russell 22 Speech Disorders Related to Head and Neck Cancer: Laryngectomy, Glossectomy, and Velopharyngeal and Maxillofacial Defects 495Tim Bressmann Part IV Cognitive and Intellectual Disorders 529 23 ADHD and Communication Disorders 531Carol Westby and Silvana M. R. Watson 24 Communication Deficits Associated with Right Hemisphere Brain Damage 571Margaret Lehman Blake 25 Traumatic Brain Injury 590Karen Lê and Jennifer Mozeiko 26 Dementia 613Nicole Müller and Zaneta Mok Author Index 643 Subject Index 666
£127.76
John Wiley and Sons Ltd Physiology of Human Reproduction
Book SynopsisPhysiology of Human Reproduction provides students with a concise and accessible overview of more than 200 vital concepts, from the basic physiology of the male and the nonpregnant female, to fertilization, embryonic and fetal growth, labor, lactation, and more. Presented in a readable style, key terms are highlighted throughout the main text to enable students to quickly find a concept and read the appropriate information. Whether reading the book from cover to cover, or using a focused approach to learn about specific concepts, readers will find this textbook to be an invaluable tool for increasing their understanding of human reproduction. An essential companion for standard Anatomy and Physiology courses, this student-friendly textbook: Covers physiology of the male, the physiology of the nonpregnant female, pregnancy and lactation, and age-related changes such as menopause Discusses pregnancy, birth control, and the reproductive system in chiTable of ContentsAcknowledgement ix Key Concepts and Terms xi Introduction 1 1 The Adult Male 3 1.1 Three Basic Requirements for Fertility in the Male 3 1.2 Endocrinology of the Male Reproductive System 4 1.3 Physiological Actions of Testosterone and Related Androgens 8 1.4 Spermatogenesis and Spermiogenesis 11 1.5 Production of Seminal Plasma 15 1.6 Testicular Thermoregulation; Varicocoele 16 1.7 Penile Erection 18 1.8 Cellular Mechanism of PDE-5 Inhibitors in Treating Erectile Dysfunction 20 1.9 Emission and Ejaculation 21 1.10 Infertility 22 2 The Nonpregnant Adult Female 25 2.1 The Menstrual Cycle: A Perspective 25 2.2 Oogenesis 26 2.3 Folliculogenesis 28 2.4 Follicular Production of Sex Steroid Hormones 31 2.5 Recruitment of the Dominant Follicle 32 2.6 Transition from the Follicular to the Ovulatory Phase: The LH Surge 33 2.7 The Luteal Phase 35 2.8 Corresponding Uterine Phases: Menstrual, Proliferative, Secretory 36 2.9 Estrogen 39 2.10 Progesterone 40 2.11 Putting It Together 41 3 Pregnancy, Parturition, Lactation 45 3.1 Fertilization and Early Embryogenesis 45 3.2 Implantation 51 3.3 Multiple Births 53 3.4 Placentation 54 3.5 The Endocrinology of Pregnancy 59 3.6 Prenatal Testing for Fetal Aneuplody and Other Maternal and Fetal Conditions 61 3.7 Maternal Adaptations During Pregnancy 63 3.8 Embryonic and Fetal Growth 65 3.9 Labor and Parturition 65 3.10 Lactation and Breastfeeding 68 3.11 Long-Term Health Effects of Pregnancy on Mother and Child 71 4 The Human Sexual Response 73 4.1 Desire Phase 73 4.2 Excitement Phase 74 4.3 Plateau Phase 75 4.4 Orgasmic Phase 75 4.5 Resolution Phase 77 5 Age-Related Changes in the Reproductive System 79 5.1 Childhood and Adolescence 79 5.2 Puberty 81 5.3 The Aging Male and Female 81 Appendix A: Detailed Anatomy of the Male and Female Reproductive Systems 83 Index 87
£31.30
John Wiley & Sons Inc Microbial Interactions at Nanobiotechnology
Book SynopsisMICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.Table of ContentsPreface xi List of Contributors xiii 1 Shape- and Size-Dependent Antibacterial Activity of Nanomaterials 1Senthilguru Kulanthaivel and Prashant Mishra 1.1 Introduction 1 1.2 Synthesis of Nanomaterials 3 1.3 Classification of NMs 4 1.3.1 Classification Based on Dimensions 5 1.3.1.1 Zero-Dimensional NMs 5 1.3.1.2 One-Dimensional NMs 6 1.3.1.3 Two-Dimensional NMs 6 1.3.1.4 Three-Dimensional NMs 6 1.3.2 Classification Based on Chemical Compositions 7 1.3.2.1 Carbon-Based NMs 7 1.3.2.2 Organic-Based NMs 7 1.3.2.3 Inorganic-Based NMs 8 1.3.3 Classification Based on Origin 9 1.4 Application of NMs 9 1.4.1 Advanced Application of NMs as Antimicrobial Agents 9 1.5 Bacterial Resistance to Antibiotics 10 1.5.1 Mechanism of Antibiotic Resistance 10 1.5.1.1 Antibiotics Modification 11 1.5.1.2 Antibiotic Efflux 12 1.5.1.3 Target Modification or Bypass or Protection 12 1.6 Microbial Resistance: Role of NMs 12 1.6.1 Overcoming the Existing Antibiotic Resistance Mechanisms 13 1.6.1.1 Combating Microbes Using Multiple Mechanisms Simultaneously 13 1.6.1.2 Acting as Good Carriers of Antibiotics 13 1.7 Antibacterial Application of NMs 15 1.7.1 Nanometals 16 1.7.2 Metal Oxides 17 1.7.3 Carbonaceous NMs 18 1.7.4 Cationic Polymer NMs 19 1.8 Interaction of NMs with Bacteria 19 1.9 Antibacterial Mechanism of NMs 20 1.10 Factors Affecting the Antibacterial Activity of NMs 22 1.10.1 Size 22 1.10.2 Shape 23 1.10.3 Zeta Potential 24 1.10.4 Roughness 24 1.10.5 Synthesis Methods and Stabilizing Agents 25 1.10.6 Environmental Conditions 26 1.11 Influence of Size on the Antibacterial Activity and Mechanism of Action of Nanomaterials 27 1.12 Influence of Shape on the Antibacterial Activity and Mechanism of Action of Nanomaterials 30 1.13 Effects of Functionalization on the Antimicrobial Property of Nanomaterials 34 1.14 Conclusion and Future Perspectives 35 Questions and Answers 36 References 38 2 Size- and Shape-Selective Synthesis of DNA-Based Nanomaterials and Their Application in Surface-Enhanced Raman Scattering 53K. Karthick and Subrata Kundu 2.1 Introduction 53 2.2 Mechanism of Surface-Enhanced Raman Scattering (SERS) 55 2.2.1 Significance of Nano-Bio Interfaces and Role of DNA in Enhancing SERS Activity 56 2.3 Size- and Shape-Selective Synthesis of Metal NPs with DNA for SERS Studies 57 2.3.1 Metal NP Assemblies on DNA Using Photochemical Route for SERS Studies 58 2.3.2 Metal NP Assemblies on DNA Using Chemical Reduction Process as Aquasol for SERS Studies 69 2.3.3 Metal NP Assemblies on DNA Using Chemical Reduction as Organosol for SERS Studies 77 2.3.4 Metal NP Assemblies on DNA Prepared Using Microwave Heating for SERS Studies 79 2.3.5 Conclusions and Outcomes of DNA-Based Metal Nanostructures for SERS Studies 83 Take Home Message 85 Questions and Answers 85 References 86 Academic Profile 90 3 Surface Modification Strategies to Control the Nanomaterial–Microbe Interplay 93T. K. Vasudha, R. Akhil, W. Aadinath, and Vignesh Muthuvijayan 3.1 Introduction 93 3.2 Factors Influencing NM–Microbe Cross talk 96 3.2.1 Surface Features of Microbes 96 3.2.2 Physicochemical Properties of NMs 97 3.3 Surface Functionalization 100 3.3.1 Techniques Used for Surface Functionalization 101 3.3.1.1 Self-Assembled Monolayers 102 3.3.1.2 Layer-by-Layer Technique 102 3.3.2 Surface Functionalization Strategies 103 3.3.2.1 Physicochemical Modifications 103 3.3.2.2 Biofunctionalization 105 3.4 Characterization of NM–Microbe Interactions 106 3.4.1 Microbe Parameters 107 3.4.2 NM Parameters 108 3.5 Toxicity of the Surface-Modified NMs 109 3.6 Challenges and Future Perspectives 110 Questions and Answers 111 Take Home Message 112 References 112 4 Surface Functionalization of Nanoparticles for Stability in Biological Systems 129Srishti Agarwal and D. Sakthi Kumar 4.1 Introduction 129 4.2 Major Processes Affecting NP Stability in Biological Media 130 4.2.1 Aggregation 130 4.2.2 Nanoparticle Design and Properties 131 4.2.3 Hydrophobicity/Hydrophilicity Effects 133 4.2.4 Effect of Protein Corona 134 4.2.4.1 Effect of Protein Corona on Active Targeting 134 4.2.5 External Factors 135 4.3 Measures to Enhance NP Stability in Biological Systems 135 4.3.1 Stabilization Against Aggregation 135 4.3.2 Ligand Exchange 136 4.3.3 Coating with Additional Layers 136 4.3.3.1 Silica Coating 137 4.3.3.2 PEG Coating 138 4.3.3.3 Lipid Bilayer Coating 141 4.3.3.4 Zwitterionic Coating 141 4.3.3.5 Protein Coating 143 4.3.3.6 Aptamer Coating 144 4.3.4 Subsiding the Nonspecific Protein Interaction 146 4.3.5 Nanoparticle Design 146 4.3.5.1 Particle Functionalization 147 4.3.6 Influence of NM Physicochemical Properties on Microbe–NM Interaction 149 4.4 Conclusion and Future Perspectives 151 4.5 Summary 152 Questions and Answers 152 References 153 5 Molecular Mechanisms Behind Nano-Cancer Therapeutics 167Surya Prakash Singh and Aravind Kumar Rengan 5.1 Nanotechnology at Nano–Bio Interfaces 167 5.2 Armory of Nanomedicine at Nano–Bio Interfaces 168 5.3 Nanoparticle Edge in Modulating Biological Process 170 5.4 Intracellular Uptake and Trafficking of Nanoparticle 173 5.5 Challenges in Clinical Applications 176 5.6 Conclusion 177 Take Home Message 177 Questions and Answers 178 References 179 6 Protein Nanoparticle Interactions and Factors Influencing These Interactions 187R. Mala and R. Keerthana 6.1 Introduction 187 6.2 Types and Biomedical Application of Nanoparticles 188 6.3 Methods and Mechanisms of Nanomaterials Synthesis 189 6.4 Routes of Entry of Nanoparticles into Biological System 190 6.5 Rationale for Studying Nanoparticles–Protein Interactions 191 6.6 Formation of Protein Corona 191 6.6.1 Structure and Composition of Corona 191 6.6.2 Kinetics of Formation of Nanoparticles–Corona 193 6.7 Nanoparticles-Induced Structural Changes in Proteins 195 6.7.1 Reversible 195 6.7.2 Irreversible 195 6.8 Factors Influencing Corona Formation 196 6.8.1 Properties of Nanoparticles 196 6.8.1.1 Size 196 6.8.1.2 Shape 198 6.8.1.3 Charge 198 6.8.1.4 Surface Functionalization 198 6.8.1.5 Surface Reactivity 199 6.8.1.6 Solubility 199 6.8.2 Properties of Protein 199 6.8.3 Effect of Surrounding Environment 201 6.8.3.1 Effect of Media Composition on Corona Formation 201 6.8.3.2 Effect of Temperature 201 6.8.3.3 Static In Vitro Model Vs. Dynamic In Vivo System 201 6.9 Interaction of Nanoparticles with Cells and Their Uptake 202 6.10 Pleiotrophic Effect of Nanoparticles 204 6.11 Analytical Methods to Study Nanoparticles–Protein Interaction 204 6.11.1 Spectral Properties 204 6.11.1.1 UV–Vis Spectroscopy 204 6.11.1.2 FTIR 205 6.11.1.3 Raman Spectroscopy 205 6.11.1.4 Fluorescence Spectroscopy 206 6.11.2 Surface Plasmon Resonance 208 6.11.3 Cellular Uptake of Nanoparticles–Protein 208 6.11.3.1 Flow Cytometry 208 6.11.3.2 Confocal Microscopy 208 6.11.4 Binding Affinity 209 6.11.4.1 Differential Scanning Calorimetry and Isothermal Calorimetry 209 6.11.4.2 Isothermal Titration Calorimetry 209 Questions and Answers 209 References 210 7 Interaction Effects of Nanoparticles with Microorganisms Employed in the Remediation of Nitrogen-Rich Wastewater 225Parmita Chawley and Sheeja Jagadevan 7.1 Introduction 225 7.2 Bacterial Nitrification Process 227 7.2.1 Effect of NPs on Functional Gene Abundance and Transcriptional Response 227 7.2.2 Effect of NPs on Enzyme Activity 229 7.2.3 Effect on Cellular Morphology 230 7.3 Effect of NPs on Denitrifying Bacteria 231 7.3.1 Effect on Functional Gene Abundance and Transcriptional Response 232 7.3.2 Enzymatic Response 234 7.4 Impact of Nanoparticles on Nitrogen Removal 236 7.5 Conclusion 236 Take Home Message 236 Questions and Answers 237 References 238 8 Silver-Based Nanoparticles for Antibacterial Activity: Recent Development and Mechanistic Approaches 245Arpita Roy, Papia Basuthakur, Shagufta Haque, and Chitta Ranjan Patra 8.1 Introduction 245 8.2 Historical Background of Silver 246 8.3 Synthesis Procedures of Silver Nanoparticles 247 8.3.1 Chemical Synthesis 247 8.3.2 Physical Methods 249 8.3.3 Biological Methods 249 8.4 Biological Application of Silver Nanoparticles 251 8.5 Bacterial Infection and Antibiotic Resistance 251 8.6 Nanosilver for Antibacterial Therapy 254 8.6.1 Metallic Silver Nanoparticles 254 8.6.2 Biosynthesized Silver Nanoparticles 254 8.6.3 Silver Nanocomposites 257 8.6.4 Silver Nanoscaffolds 260 8.7 Influence of Size and Shape of Silver Nanoparticles as Antibacterial Agents 260 8.8 Nanosilver and Its Mechanism of Action for Antibacterial Therapy 261 8.9 Application of Silver Nanoparticle in Commercial Products 266 8.9.1 Silver Nanoparticles in Wound Dressing Materials and Devices 266 8.9.2 Silver Nanoparticles in Soaps and Detergents 268 8.9.3 Silver Nanoparticles in Fabrics 269 8.9.4 Silver Nanoparticles in Cosmetics 271 8.9.5 Silver Nanoparticles in Food Packaging 271 8.9.6 Silver Nanoparticles in Paints 273 8.10 Toxicity of Silver Nanoparticles 273 8.11 Future Prospective and Challenges 275 8.12 Conclusion 276 Take Home Message 276 Questions and Answers 277 Abbreviation 278 References 280 9 Microbial Gold Nanoparticles and Their Biomedical Applications 303Dindyal Mandal, Rohit Kumar Singh, Uday Suryakant Maharana, Bijayananda Panigrahi, and Sourav Mishra 9.1 Introduction 303 9.2 Microbial Gold Nanoparticles Synthesis 304 9.2.1 Bacteria-Mediated Gold Nanoparticles 306 9.2.2 Algae-Mediated Gold Nanoparticles 308 9.2.3 Fungi-Mediated Gold Nanoparticles 311 9.2.4 Yeast-Mediated Gold Nanoparticles 315 9.2.5 Mechanism Involved in Microbial Nanoparticles Synthesis 315 9.3 Applications of Microbial Gold Nanoparticles 317 9.3.1 Biosensing 317 9.3.2 Antibacterial Activity of Au NPs 318 9.3.3 Anticancer Activity of Microbial Gold Nanoparticles 321 9.4 Conclusion 322 Take Home Message 323 Questions and Answers 323 References 325 10 Nano-Bio Interactions and Their Practical Implications in Agriculture 337Achintya N. Bezbaruah and Ann-Marie Fortuna 10.1 Introduction 337 10.1.1 Agriculturally Beneficial Soil Microorganisms 339 10.2 Engineered Nanomaterials and Agriculture 340 10.2.1 Pathways for ENM to Soil 340 10.2.2 Fate of ENMs in Soil 340 10.2.3 Chemical Interactions of ENM in Soil 343 10.2.4 Mechanisms Controlling Heteroaggregation 344 10.2.5 Mobility of Colloids and ENMs in Soil 344 10.2.6 Nanoagriculture 345 10.2.7 Nanopesticides 348 10.2.8 ENMs and Agriculturally Beneficial Microorganisms 349 10.3 Summary 352 References 353 11 Biogeochemical Interactions of Bioreduced Uranium Nanoparticles 359S. Sevinç Şengör and Rajesh K. Sani 11.1 Introduction 359 11.2 Coupled Biogeochemical Mechanisms and Interactions of U in the Subsurface 361 11.3 Biogenic Uraninite Precipitation and Its Nanoparticulate Forms 367 11.4 Re-oxidation and Stability of Bioreduced Uranium 371 11.5 Summary and Conclusions 373 Questions and Answers 374 References 376 12 Characterization and Quantification of Mobile Bioreduced Uranium Phases 383S. Sevinç Şengör and Rajesh K. Sani 12.1 Introduction 383 12.2 Characterization of Biogenic U(IV) 384 12.3 Quantification of Mobile Bioreduced U(IV) Nanoparticles 386 12.4 Summary and Conclusions 388 Questions and Answers 389 References 391 Index 395
£146.66
John Wiley and Sons Ltd Temporomandibular Disorders
Book SynopsisA valuable resource on how to diagnose and treat temporomandibular disorders (TMD) The newly and thoroughly revised 2nd Edition of Temporomandibular Disorders: A Problem-Based Approach delivers a systematic and logical approach to diagnosing and treating temporomandibular disorders. Using a case-based approach to assist readers with understanding and retention, the book discusses the practical realities of managing patients and promoting effective treatment of temporomandibular disorders. Containing full colour clinical images and diagrams throughout, the chapters include practical guides on how to make splints and samples of patient information sheets which can be used as templates. Readers will get access to topics such as: The clinical aspects of anatomy, function, pathology, and classification Differential diagnosis of temporomandibular joint problems Clicking joint problems and the use of preliminary investigation in diTable of ContentsPreface to the Second Edition ix Acknowledgements xi About the Companion Website xiii 1 About the Book 1 About temporomandibular disorders: what is a ‘TMD’? 1 About the book 2 Chapter 2: Clinical aspects of anatomy, function, pathology, and classification 3 Chapter 3: Articulatory system examination 3 Chapter 4: I’ve got ‘TMJ’ 3 Chapter 5: I’ve got a clicking joint 3 Chapter 6: I’ve got a locking joint 3 Chapter 7: I’ve got a grating joint 3 Chapter 8: You’ve changed my bite 4 Chapter 9: I’ve got pain in my face 4 Chapter 10: I’ve got a dislocated jaw 4 Chapter 11: My teeth are worn 4 Chapter 12: I’ve got a headache 4 Chapter 13: I’ve got whiplash 4 Chapter 14: What’s of use to me in practice? 5 Chapter 15: You and the lawyer 5 Chapter 16: The referral letter 5 Chapter 17: How to make a splint 5 Chapter 18: Bruxism: Current knowledge of aetiology and management 5 Chapter 19: Splint therapy for the management of TMD patients: An evidence-based approach 5 Chapter 20: Patient information 6 Appendix I: Flowcharts 6 Appendix II: Glossary of terms 6 Appendix III: Short answer questions 6 2 Clinical Aspects of Anatomy, Function, Pathology, and Classification 7 The joint anatomy, histology, structure, capsule, synovial membrane, and fluid, ligaments 7 The intra-articular disc (meniscus) 11 The bones of the temporomandibular joint 15 Mandibular (jaw/masticatory) muscles 16 Classification and Pathology 25 Diagnoses of TMDs 29 Further Reading 31 3 Articulatory System Examination 32 Examination of the temporomandibular joints 32 Mandibular (masticatory) muscle tenderness 39 Further Reading 50 4 I’ve Got ‘TMJ’! 52 History 52 Examination 53 Special tests 55 Differential diagnosis 55 Management 56 5 I’ve Got a Clicking Joint 64 History 64 Examination 65 Other special tests 67 Treatment 74 The patient journey 79 6 I’ve Got a Locking Joint 82 History 82 Examination 1 83 Diagnosis 85 Treatment 86 TMJ locking 88 Conclusion 90 7 I’ve Got a Grating Joint 91 Examination 91 Diagnosis 92 Treatment 92 Final treatment plan 95 8 You’ve Changed My Bite 101 History 101 Examination 104 Treatment 104 Discussion 106 Conclusion 111 Further Reading 112 9 I’ve Got Pain in My Face 114 History 114 Examination 115 Differential diagnosis 116 Treatment 121 Questions to ask patients regarding pain in general 122 Further Reading 123 10 I’ve Got a Dislocated Jaw 125 Examination 126 Likely diagnoses 126 Management 127 11 My Teeth Are Worn 132 History 132 Examination 133 Diagnosis 135 Treatment 135 Important considerations in tooth surface loss 136 Further reading 147 12 I’ve Got a Headache 148 Examination 149 Radiographs 149 Articulatory system exam 150 Likely diagnosis 151 Management 153 Patient journey 154 Further Reading 155 13 I’ve Got Whiplash 156 Examination 157 Record-keeping 158 Are TMD and whiplash related? 159 Likely diagnosis 161 Management 161 14 What’s of Use to Me in Practice? 164 Counselling and reassurance 165 Drug therapy 165 Physiotherapy 166 Splint therapy 168 Mouth prop 171 Occlusal adjustments 171 Does orthodontic treatment cause TMD? 175 Restorative treatment, the dentist, and TMD 176 The use of a facebow and semi-adjustable articulators 177 Radiographs 178 Further referral 178 15 You and the Lawyer 182 Case scenario 1: note and record-keeping 182 Case scenario 2: a medical report request 185 Case scenario 3: a disgruntled patient 188 Further Reading 191 16 The Referral Letter 192 Details 192 History 192 Request 194 Further Reading 194 17 How to Make a Splint 195 How do you make a stabilisation splint? 195 Fitting a stabilisation splint 205 How do you make an anterior repositioning splint? 211 Bite registration 213 Further reading 217 18 Bruxism: Current Knowledge of Aetiology and Management 218 Aetiology of bruxism 218 Definition of bruxism 219 Bruxism and TMD 220 Why bruxism (parafunction) is potentially damaging? 221 How much evidence about the efficacy of botulinum toxins on bruxism? 221 How can bruxism be managed? 222 Further reading 223 19 Splint Therapy for the Management of TMD Patients: An Evidence-Based Discussion 224 Stabilisation splint (SS) 225 Anterior repositioning splint (ARPS) 228 Mandibular advancement/snoring appliances 231 20 Patient Information 235 Stabilisation splint 235 Anterior repositioning splint 236 Use and care of occlusal bite splint 236 General advice for patients with a TMD 238 Exercise programme for patients with TMD 239 Appendix I Flowcharts 241 Appendix II Glossary of Terms 253 Further Reading 274 Appendix III Short Answer Questions 275 Index 277
£73.76
John Wiley and Sons Ltd Emergency Medicine Simulation Workbook
Book SynopsisEmergency Medicine Simulation Workbook provides medical educators with clear and systematic guidance on incorporating medical simulation into their curriculum. Now in its second edition, this invaluable workbook helps those tasked with training emergency physicians, nurses, and technicians deliver the highest quality training and achieve optimal results. Chapters written by a team of expert authors explain how to use advanced simulation technology to realistically portray clinical scenarios without any risk to real patients. Fully annotated cases cover key topics including cardiovascular, thoracic and respiratory emergencies, trauma, toxicologic and infectious emergencies, and more. Throughout the text, practical tips and tricks accompany case images and patient data to help educators easily deploy simulation-based learning and tailor their curriculum for novice and advanced students alike. This workbook also: Helps medical educators train students in diverse sTable of ContentsContributors, vii Abbreviations, x About the Companion Website, xiii Introduction, 1 1 Abdominal/Gastroenterology Emergencies, 3Michele Callahan 2 Cardiovascular Emergencies, 43Mark J. Bullard and Catherine M. Wares 3 Cutaneous Emergencies, 74Daa’iyah R. Cooper and Afrah A. Ali 4 Environmental Emergencies, 109Moira Davenport and Brittany N. Muller 5 Hematologic and Oncologic Emergencies, 132Ashley Pickering and Sarah B. Dubbs 6 Immune System Emergencies, 163Ashley C. Crimmins 7 Systemic Infectious Emergencies, 191Donald T. Ellis, II 8 Nontraumatic Musculoskeletal Emergencies, 229Andrew Ortega and Nur-Ain Nadir 9 Obstetric/Gynecologic Emergencies, 259Catherine M. Wares and Mark J. Bullard 10 Nervous System Emergencies, 289Danya Khoujah and Wan-Tsu W. Chang 11 Psychobehavioral Emergencies, 337Afrah A. Ali and Danya Khoujah 12 Renal and Urogenital Emergencies, 371Rupal Jain, Diane Kuhn, and Sarah B. Dubbs 13 Thoracic and Respiratory Emergencies, 404Michael Billet 14 Toxicologic Emergencies, 430Charles Lei, Jeffrey N. Heimiller, and Joseph R. Sikon 15 Traumatic Emergencies, 466Charles Lei, Jeffrey N. Heimiller, and Joseph R. Sikon Index, 504
£52.20
John Wiley and Sons Ltd Liver Transplantation
Book SynopsisExplore this practicaland step-by-step guide to managing liver transplant patients from leading internationalcliniciansin Hepatology The newly revised Second Edition ofLiver Transplantation: Clinical Assessment and Managementdeliversexpert clinical guidance on best practices in managing the care of liver transplant patients.Authors are all experts in theirfield and cover a world-wide perspective.Organizedin an accessible, stepwise fashion and packed with text featuressuch askey points, the book covers all critical areasof each stage oftheliver transplantjourney, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient,learn the principles of the procedure and thelong termmanagement of the transplant recipient.Liver Transplantationprovidesthe entire hepatology and surgical team the information required for a sound understaTable of ContentsList of Contributors x Foreword to the Second Edition xx Foreword to the First Edition xxi Preface xxii Abbreviations xxiii Part 1 When to Refer a Patient for Liver Transplantation 1 1 Overview on Organ Donation and Liver Transplantation 3Michael Ronan Lucey 2 Predicting Outcomes and Use and Abuse of Prognostic Models 11Moira B. Hilscher and Patrick S. Kamath Part 2 Selection, Assessment, and Management on the List 19 3 Assessment of the Potential Transplant Recipient 21Michael L. Volk 4 Frailty and the Potential Liver Transplant Candidate 27Matthew J. Armstrong and Jennifer C. Lai 5 Alcohol Use (excluding Alcohol-Related Liver Disease), Tobacco, Marijuana, and Illicit Drugs 33John P. Rice 6 The Role of the Psychiatric Consultant in the Selection, Assessment, and Management of Liver Transplant Patients 39Robert M. Weinrieb and Arpita Goswami-Banerjee 7 When Liver Transplant Patients Do Not Adhere to Therapeutic Plans 48Kerry Webb and Rowena Jones 8 Liver Transplant Assessment for Young People: Addressing the Needs of Young People with Liver Disease 55Marianne Samyn and Jemma Marie Day 9 Assessment and Management of the Patient with Hepatitis C 64Emma L. Hathorn and David J. Mutimer 10 Management of Hepatitis B Virus Infection Pre Transplantation 68Bruno Roche and Didier Samuel 11 Transplantation for the Management of Malignancy 74Adiba I. Azad, Julie K. Heimbach, and Gregory J. Gores 12 Assessment and Management of the Liver Transplant Candidate with Acute-on-Chronic Liver Failure 82Giovanni Perricone and Rajiv Jalan 13 Assessment and Management of the Transplant Candidate with Alcohol-Associated Liver Disease 96Stéphanie Faure, Magdalena Meszaros, Lucy Meunier, Hélène Donnadieu-Rigole, and Georges-Philippe Pageaux 14 Non-alcoholic Fatty Liver Disease as an Indication for Liver Transplantation 104Paul Horn and Philip N. Newsome 15 Consent 109Christopher J.E. Watson 16 Prehabilitation and General Management 116Matthew J. Armstrong and Felicity R. Williams 17 Removal of Patients from the Liver Transplant Waiting List 123John O’Grady 18 Palliative Care and Liver Transplantation 126Mina Rakoski and Puneeta Tandon Part 3 Transplantation for Acute Liver Failure 135 19 Assessment of the Patient with Acute Liver Failure 137Ashley Barnabas and John O’Grady 20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation 143Robert J. Fontana Part 4 Donation and Allocation 153 21 Ethical and Legal Aspects of Organ Donation 155Jessica Mellinger 22 Liver Allocation, Including Principles of Organ Allocation 161Parita Patel and Michael Charlton 23 Living Donor Liver Transplant in Children 168Adebowale A. Adeyemi, Elizabeth B. Rand, and Kim M. Olthoff 24 Living Liver Donation in Adults 180Mohamed Rela and Ashwin Rammohan 25 Deceased Liver Donors: Standard and Expanded Criteria 190Shareef Syed and Sandy Feng 26 Donor-Transmitted Disease 203James Neuberger 27 Liver Donation and Preservation 209Navneet Tiwari and Hynek Mergental 28 Liver Retrieval and Preservation 223Carlo D.L. Ceresa, Brian R. Davidson, Peter J. Friend, and Rutger J. Ploeg 29 Alternatives to Whole Graft Liver Transplantation 236Paolo Muiesan, Alessandro Parente, and Hector Vilca-Melendez 30 Surgical Aspects of Deceased Donor Transplantation 252Amit Nair, K.V. Narayanan Menon, Cristiano Quintini, and Charles Miller Part 5 Care of the Liver Transplant Recipient 265 31 Outcomes after Liver Transplantation 267James Neuberger 32 Outpatient Follow-Up of Liver Transplant Recipients 276Amardeep Khanna and James Ferguson 33 Medication Adherence 285Maureen Whitsett and Josh Levitsky 34 Transitional Care 299Fiona Thompson 35 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests 303Joanna A. Leithead 36 The Immune System in Liver Transplantation: Rejection versus Tolerance 317Palak J. Trivedi and Nick D. Jones 37 Immunosuppressive Medications: Liver Transplantation 334Tim Mitchell and Gerry MacQuillan 38 Immunosuppression in Liver Transplantation 344Nicholas Lim and John R. Lake 39 Patterns of Liver Allograft Rejection 353Geoffrey W. McCaughan, Ken Liu, Avik Majumdar, Patrick Bertolino, David G. Bowen, and Simone I. Strasser 40 De Novo Autoimmune Hepatitis 360James Neuberger 41 Managing Rejection 364Neil Halliday and Douglas Thorburn 42 Withdrawal of Immunosuppression after Liver Transplantation 386Luca Toti, Tommaso Maria Manzia, Francesca Blasi, and Giuseppe Tisone 43 Liver Transplant Pathology 393Owen L. Cain and Stefan G. Hübscher 44 Care of the Liver Transplant Recipient: Management of Renal Function 403Andres F. Carrion and Paul Martin 45 Managing Cardiovascular Risk in the Liver Transplant Recipient 409Manhal Izzy and Kymberly D. Watt 46 Bone Disease in Liver Transplantation 418John Ayuk 47 Diagnosis and Management of Recurrent Autoimmune Liver Disease 424Fernanda Q. Onofrio, Nazia Selzner, and Gideon M. Hirschfield 48 NAFLD and NASH in the Patient after Liver Transplantation 438Paul Horn and Philip N. Newsome 49 Recurrent Metabolic Diseases 445James Neuberger 50 Treatment of Hepatitis C in the Transplant Setting 449Jeffrey Kahn and Norah A. Terrault 51 Management of Hepatitis B Virus Infection Post Transplantation 458Bruno Roche and Didier Samuel 52 Antimicrobial Prophylaxis Following Liver Transplantation 469Michael J. Williams and Peter C. Hayes 53 Cytomegalovirus and the Liver Transplant Recipient 475James Ferguson 54 Post-Liver Transplant Infections 481Miruna David and Ahmed Elsharkawy 55 De Novo Malignancies after Liver Transplantation 493Simone I. Strasser, Ken Liu, Avik Majumdar, and Geoffrey W. McCaughan 56 Post-Transplant Lymphoproliferative Disorders 500Jose Ignacio Herrero 57 Quality of Life and Employment after Liver Transplantation 507Santiago Tome, Esteban Otero, and Michael Ronan Lucey 58 Sexual Function, Fertility, and Pregnancy in Liver Disease and after Liver Transplantation 514Patrizia Burra, Salvatore Stefano Sciarrone, and Patrizio Bo 59 Common Drug Interactions 519Amanda Smith 60 Immunization and Liver Transplantation 525Jessica Hause and Erin Spengler Postscript 529James Neuberger Index 531
£118.76
John Wiley and Sons Ltd Questions and Answers in Oral Health Education
Book SynopsisTable of ContentsAcknowledgements ix About the Authors x Introduction xi How to use Question and Answers in Oral Health Education xii About the Companion Website xiv Roles and Responsibilities xv General Dental Council xxxvii Revision 1 Revision 1: Acronyms and Abbreviations 2 Revision 2: Methods of Retaining Information 5 Revision 3: Caries 7 Revision 4: Fluoride 11 Revision 5: Visual Aids 17 Revision 6 Muscles of Mastication 24 Revision 7: Oral Conditions 25 Revision 8: Oral Hygiene Aids 32 Revision 9: Plaque 37 Revision 10: Sugars 43 Revision 11: Toothbrushing Techniques 48 1 Oral Health Messages 50 2 Eruption 56 3 Anatomy and the Oral Mucosa 61 4 Saliva 69 5 Periodontal Disease and Plaque 75 6 Caries 82 7 Sugar 88 8 Tooth Surface Loss 94 9 Visual Aids 100 10 Aims and Objectives 104 11 Lesson Preparation and Communication 110 12 Socio-Economic Classification, Class, and Socialisation 119 13 Fluoride and Fissure Sealants 124 14 Oral Conditions and Oral Cancers 130 15 Legislation and GDC Standards 135 16 Screening, Surveys, Indices, Epidemiology, Prevalence, and Incidence 140 17 General Health 144 18 Medical Emergencies 154
£31.30
John Wiley and Sons Ltd The Peripheral TCell Lymphomas
Book SynopsisTHE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group's unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classTable of ContentsContributors xix About the Companion Website xxiii Part I Biological Basis of the Peripheral T-cell Lymphomas 1 1 The Fundamentals of T-cell Lymphocyte Biology 3Claudio Tripodo and Stefano A. Pileri Introduction 3 General View of the Differentiation and Function of T Lymphocytes 3 The T-cell System as a Frame for Peripheral T-cell Lymphoma: Taking Plasticity into Account 5 Must Reads 7 References 7 2 Mechanisms of T-cell Lymphomagenesis 9François Lemonnier, Philippe Gaulard and Laurence de Leval Introduction 9 Oncogenic Events in the Transformation of T or Natural Killer Cells 9 Genetic Lesions 9 Deregulated Pathways in Peripheral T-cell Lymphoma Oncogenesis (Figure 2.1, Table 2.1) 10 Signaling Pathways 13 Cell-cycle Control 14 Immune Surveillance 14 Role of the Microenvironment in Peripheral T-cell Lymphoma 15 The Model of Angio-immunoblastic T-cell Lymphoma and T Follicular Helper-derived Peripheral T-cell Lymphoma 15 Specific Microenvironment Components Present in Other Primary Cutaneous T-cell Lymphoma Entities 16 Underlying Factors Favoring the Tumor Transformation 18 Viruses 18 Chronic Antigenic Stimulation 19 Other Factors 19 Cell of Origin (Table 2.1) 20 Conclusion 22 Must Reads 22 References 22 3 Epigenetics of T-cell Lymphoma 27H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen A. O’Connor and Sean Harrop Introduction 27 Epigenetic Pathways Altered in T-cell Lymphoma 27 Epigenetic Changes Within Specific T-cell Lymphoma Subtypes 31 Peripheral T-cell Lymphoma Not Otherwise Specified 32 Angioimmunoblastic T-cell Lymphoma and Peripheral T-cell Lymphoma with T Follicular Helper Phenotype 32 Anaplastic Large-cell Lymphoma 33 Adult T-cell Leukemia/Lymphoma 33 Intestinal T-cell Lymphoma 34 Hepatosplenic T-cell Lymphomas 34 Extranodal Natural Killer/T-cell Lymphoma 34 Mycosis Fungoides and Sézary Syndrome 35 Established and Emerging Drugs Targeting the T-cell Lymphoma Epigenome 35 DNA Methyltransferase Inhibitors 35 Isocitrate Dehydrogenase Inhibitors 36 EZH2 Inhibitors 37 BET Inhibitors 38 Protein Arginine Methyltransferases Inhibitors 38 Combination Therapies Involving Epigenetic Targeting Agents 38 Future Directions 38 Must Reads 39 References 39 4 Animal Models of T-cell Lymphoma 47Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe and Mamiko Sakata-Yanagimoto Introduction 47 Angioimmunoblastic T-cell Lymphoma 50 The ROQUIN Mouse Model 50 The Mouse Models Recapitulating Human Angioimmunoblastic T-cell Lymphoma Genomic Features 50 Tet2 Gene Trap Mice 50 G17V RHOA Mouse Model 50 PDX Models of Angioimmunoblastic T-cell Lymphoma 51 Anaplastic Large T-cell Lymphoma 51 Viral and Chimeric Models 51 Transgenic Models 51 CRISPR-Based Models 52 PDX Models of Anaplastic Large-Cell Lymphomas 52 Human T-cell Lymphotropic Virus Type 1 Adult T-cell Leukemia/Lymphoma 52 Mice Expressing HTLV-1 Viral Proteins 52 PDX Models of Adult T-cell Leukemia/Lymphoma 52 Cutaneous T-cell Lymphoma 53 Enteropathy-associated T-cell Lymphoma 53 Conclusion 53 Must Reads 53 References 54 Part II Epidemiology and Classification of the PTCL 57 5 Geographic Distribution of the Peripheral T-cell Lymphomas 59Global Epidemiology Amulya Yellala, Avyakta Kallam and James O. Armitage Historical Perspective 59 Epidemiology 60 Peripheral T-cell Lymphoma, Not Otherwise Specified 60 Angioimmunoblastic T-cell Lymphoma 61 Anaplastic Large-cell Lymphoma 61 Adult T-cell Lymphoma/Leukemia (HTLV Associated) 62 Extranodal NK/T-cell Lymphomas 62 T-cell Prolymphocytic Leukemia 62 Large Granular Lymphocytic Leukemia 62 Primary Cutaneous Gamma/Delta PTCL 63 Enteropathy Associated T-cell Lymphomas and Monomorphic Epitheliotropic Intestinal T-cell lymphoma 63 Hepatosplenic T-cell Lymphoma 63 The Cutaneous T-cell Lymphomas 63 Conclusion 63 Must Reads 64 References 64 6 Classification of the Peripheral T-cell Lymphomas 69Neval Ozkaya and Elaine S. Jaffe Introduction 69 Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T follicular Helper Cell Origin 69 Angioimmunoblastic T-cell Lymphoma 70 Follicular T-cell Lymphoma 71 Nodal Peripheral T-cell Lymphoma with T-follicular Helper Phenotype 71 Peripheral T-cell Lymphoma Not Otherwise Specified 71 Anaplastic Large-cell Lymphomas 72 Anaplastic Large-cell Lymphoma, ALK-Positive 72 Anaplastic Large-cell Lymphoma, ALK-Negative 72 Breast Implant-associated Anaplastic Large-cell Lymphoma (Provisional) 73 Adult T-cell Leukemia/Lymphoma 74 Intestinal T-cell Lymphomas 74 Enteropathy-associated T-Cell Lymphoma 75 Monomorphic Epitheliotropic Intestinal T-cell Lymphoma 76 Intestinal T-cell ymphoma, Not Otherwise Specified 76 Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract (Provisional) 77 NK-Cell Enteropathy 78 Hepatosplenic T-cell Lymphoma 78 Mycosis Fungoides 78 Sézary Syndrome 79 Primary Cutaneous CD30-positive T-cell Lymphoproliferative Disorders 79 Lymphomatoid Papulosis 79 Primary Cutaneous Anaplastic Large-cell Lymphoma 80 Subcutaneous Panniculitis-like T-cell Lymphoma 80 Primary Cutaneous Gamma–Delta T-cell Lymphoma 80 Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma (Provisional) 81 Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder (Provisional) 81 Primary Cutaneous Acral CD8+ T-cell Lymphoma (Provisional) 82 Large Granular Lymphocytic Leukemia 82 T-cell Large Granular Lymphocytic Leukemia 82 Chronic Lymphoproliferative Disorder of NK Cells (Provisional) 82 T-cell Prolymphocytic Leukemia 82 NK-cell Lymphomas 83 Extranodal NK/T-cell Lymphoma, Nasal Type 83 Aggressive NK-cell Leukemia 83 EBV-positive T-cell and NK-cell Lymphoproliferative Diseases of Childhood 83 Must Reads 84 References 84 7 Molecular Classification of the Peripheral T-cell Lymphomas 91Tyler A. Herek and Javeed Iqbal Introduction 91 T-cell Development and Activation: An Overview 92 T-cell Receptor Signaling 92 Derivation of Diagnostic Signatures for Molecular Classification of Peripheral T-cell Lymphomas 95 Angioimmunoblastic T-cell Lymphoma and Other T Follicular Helper-derived Malignancies 95 Recurrent Genetic Features 96 Anaplastic Large-cell Lymphomas 96 Recurrent Genetic Features 96 Adult T-cell Leukemia/Lymphoma 97 Recurrent Genetic Features 97 Peripheral T-cell Lymphoma Not Otherwise Specified 97 Recurrent Genetic Features in Two Novel Subgroups 98 Hepatosplenic T-cell Lymphoma 98 Recurrent Genetic Features 98 Extranodal natural killer/T-cell Lymphoma 98 Recurrent Genetic Features 99 Cutaneous T-cell Lymphomas 99 Conclusion 99 Must Reads 99 References 99 Part III Discrete Clinical Subtypes of PTCL (Unique Epidemiology, Therapy and Management) 105 8 Peripheral T-cell Lymphoma Not Otherwise Specified 107N. Nora Bennani and Stephen M. Ansell Introduction 107 Epidemiology, Risk Factors, and Clinical Characteristics 107 Basic Principles of Disease Biology 108 Prognostic Tools 109 Frontline Therapy 110 Management of Relapsed or Refractory Disease 111 Future Directions 112 Must Reads 112 References 112 9 Angioimmunoblastic T-cell Lymphoma 115Jehan Dupuis and Franck Morschhauser Introduction 115 Clinical and Biological Presentation 115 Epidemiology and Risk Factors, Disease Incidence and Prevalence 117 Basic Principles of Disease Biology 118 TET2 Mutations 119 IDH2 Mutations 120 DNMT3A Mutations 120 Rho A Mutations 121 CD28 Alterations 121 Other Mutations Affecting the T-cell Lymphoma Pathway 121 Management of Disease in the Front Line 122 Management of Relapsed or Refractory Disease 122 Conventional Chemotherapy Agents 123 Bendamustine 123 Pralatrexate 123 Romidepsin 124 Belinostat 124 Newer Targeted Therapy Approaches 125 Future Directions 125 Must Reads 126 References 126 10 The Spectrum of Anaplastic Large-cell Lymphoma 129Jianping Kong and Andrew L. Feldman Introduction 129 Epidemiology and Risk Factors 129 Disease Incidence and Prevalence 131 Basic Principles of Disease Biology 133 Management of Disease in the Front Line 134 Management of the Relapsed or Refractory Patient 137 Future Directions 138 Acknowledgement 140 Must Reads 140 References 140 11 Human T-cell Lymphotropic Virus Type 1 Positive Adult T-cell Leukemia/Lymphoma 145Wataru Munakata and Kensei Tobinai Epidemiology and Disease Incidence 145 Basic Principles of Disease Biology 145 CCR4 and Adult T-cell Leukemia/Lymphoma 146 Clinical Features of Adult T-cell Leukemia/Lymphoma 146 Prognosis and Prognostic Index of ATLL 147 Front-line Management of Aggressive Adult T-cell Leukemia/Lymphoma 149 Chemotherapy and Hematopoietic Stem-cell Transplantation 149 Mogamulizumab with Dose-intensified Chemotherapy 150 Interferon alpha and Antiretroviral Agents 151 Chemotherapy in Transplant-ineligible Patients with Aggressive Adult T-cell Leukemia/Lymphoma 151 Front-line Management of Indolent ATLL 152 Management of Relapsed or Refractory Patients 152 Mogamulizumab Monotherapy 152 Lenalidomide Monotherapy 153 Other Treatments for Relapsed or Refractory Adult T-cell Leukemia/Lymphoma 153 Future Directions 154 Must Reads 154 References 154 12 Natural Killer/T-cell Lymphomas 159Seok Jin Kim, Ritsuro Suzuki, Arnaud Jaccard, Soon Thye Lim and Wong Seog Kim Introduction 159 Epidemiology and Risk Factors 161 Disease Incidence and Prevalence 161 Basic Principles of Disease Biology 161 Genetic Susceptibility to NK/T-Cell Lymphoma 161 Molecular Pathogenesis 162 JAK–STAT and Associated Pathways 162 Nuclear Factor Kappa B and Other Deregulated Pathways 163 The Programmed Cell Death 1/Programmed Death Ligand 1 Pathway 163 Management of Newly Diagnosed Treatment-naïve Patients 163 Diagnosis and Initial Assessment 164 Monitoring the Response 165 Treatment Strategies 165 Localized Disease 165 Disseminated Disease 167 Consolidation Treatment with Hematopoietic Stem-cell Transplantation 167 Management of Relapsed or Refractory Disease 167 Treatment of Localized Nasal Relapse 167 Treatment of a Systemic Relapse 167 Novel Agents for Relapsed or Refractory ENKTL 168 Future Directions 168 Must Reads 168 References 169 13 T-Prolymphocytic Leukemia 175Dima El-Sharkawi and Claire Dearden Introduction 175 Incidence 175 Clinical Features 175 Laboratory Findings 175 Treatment 176 Stem-cell Transplantation 178 Treatment for Relapsed/Refractory Disease 178 Future Directions 178 Must Reads 179 References 179 14 Large Granular Lymphocyte Leukemia 183Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith and Thomas P. Loughran, Jr Introduction 183 Epidemiology and Risk Factors 183 Prevalence of Concomitant Disorders 184 Autoimmune Diseases 184 Hematological Disorders 184 Basic Principles of Disease Biology 185 Biology 185 STAT3 Dysregulation 185 STAT3 and Common Cytopenias 186 JAK–STAT Pathway 187 Other Mutated and Dysregulated Pathways 187 Chronic Activation and Large Granular Lymphocyte Clonal Malignancy 188 STAT3 and Clonality 188 Antigenic Stimulation 188 Immune System Dysregulation 189 Cytotoxic Killer Cells and Autoimmunity 189 Humoral Abnormalities 189 Abnormal Bone Marrow 190 Neutropenia and Rheumatoid Arthritis 190 Spleen Pathology 191 Management of Disease in the Front Line 191 Diagnosis 191 Prognosis 191 Current Treatments 192 Indications for Treatment 192 Evaluation of Treatment Response 192 Therapeutic Approach 192 Canonical Immunosuppressive Treatments 192 Non-canonical Immunosuppressive Treatments 193 Supportive Therapy 194 Summary of Therapeutic Recommendations 194 Management of Relapsed or Refractory Disease 194 Future Directions 194 JAK–STAT Pathway Targeting 194 Natural Compounds 196 Other Candidate Agents 196 Funding 196 Disclosures 197 Must Reads 197 References 197 15 Gamma–Delta T-cell Lymphomas 203Francine Foss, Aadil Ahmed and Mina Xu Introduction 203 Epidemiology and Risk Factors 203 Biology of Primary Cutaneous Gamma–Delta T-cell Lymphoma 204 Management of Disease in the Front Line 206 Management of Relapsed/Refractory Disease 208 Must Reads 209 References 209 16 Enteropathy-Associated and Monomorphic Epitheliotropic Intestinal T-cell Lymphomas 211Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave and Govind Bhagat Introduction 211 Enteropathy-associated T-cell Lymphoma 211 Epidemiology and Risk Factors 211 Disease Incidence and Prevalence 212 Basic Principles of Disease Biology 212 Morphology and Immunophenotype 212 Molecular and Genetic Alterations 212 Management of Patients in the Front Line 213 Management of the Relapsed or Refractory Patient 214 Future Directions 214 Refractory Celiac Disease 214 Disease Definition, Risk Factors, Incidence, and Prevalence 214 Basic Principles of Disease Biology 214 Morphology and Immunophenotype 214 Molecular and Genetic Alterations 215 Management of Patients in the Front-Line 216 Management of the Relapsed or Refractory Patient 216 Future Directions 216 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma 216 Disease Risk Factors, Incidence, and Prevalence 216 Basic Principles of Disease Biology 216 Morphology and Immunophenotype 216 Molecular and Genetic Alterations 218 Management of Disease in the Front Line 218 Management of Relapsed or Refractory Disease 218 Future Directions 218 Must Reads 218 References 219 17 Hepatosplenic T-cell Lymphomas 225Robert N. Stuver, Mwanasha Merrill and Salvia Jain Epidemiology and Disease Incidence 225 Basic Principles of Disease Biology 227 Clinical Features 227 Management of Disease in the Front Line 228 Management of the Relapsed or Refractory Disease 229 Splenectomy 230 Future Directions 230 Funding 231 Must Reads 231 References 231 18 Cutaneous T-cell Lymphoma 235Alejandro A. Gru, Bethanie Rooke, Kevin Molloy and Julia Scarisbrick Introduction 35 Epidemiology and Risk Factors 236 Basic Principles of Disease Biology 237 Clinical, Pathologic, and Immunophenotypic Findings 240 Management of Front-Line Mycosis Fungoides/Sézary Syndrome 247 Early-stage Disease (Stages IA–IIA) 248 Late-stage Disease (Stage IIB–IVA2) 250 Stage IIB (Tumor-stage Disease) 250 Stage III–IVA1 Disease (Erythrodermic Disease and Sézary) 250 Stage IVA2–IVB Disease 250 Management of Relapsed or Refractory Disease with Mycosis Fungoides/Sézary Syndrome 250 Early-stage Disease (Stage IA–IIA) 250 Late-stage Disease (IIB–IVA2) 251 Stage IIB (Tumor-stage Disease) 251 Stage III–IVA1 (Erythrodermic Disease) 251 Stage IVA2–IVB Disease 252 Front-Line Management of Non-mycosis Fungoides Cutaneous T-cell Lymphomas 252 Management of Relapsed or Refractory Non-mycosis Fungoides Cutaneous T-cell Lymphomas 252 Future Directions 252 Must Reads 253 References 253 19 Other Rare Subtypes of Peripheral T-cell Lymphoma 259Pier Paolo Piccaluga Introduction 259 Chronic Lymphoproliferative Disorders of Natural Killer Cells 259 Epidemiology and Risk Factors 259 Disease Incidence and Prevalence 259 Basic Principles of Disease Biology 260 Management of Front-line Disease 260 Epstein–Barr Virus-associated T-cell and NK-cell Lymphoproliferative Disorders of Childhood 260 Systemic Epstein–Barr Virus-positive T-cell Lymphoma of Childhood 260 Epidemiology and Risk Factors 260 Basic Principles of Disease Biology 260 Management of Front-Line Disease 261 Chronic Active Epstein–Barr Virus Infection of T- and NK-cell Type, Systemic Form 261 Epidemiology and Risk Factors 261 Basic Principles of Disease Biology 261 Management of Front-Line Disease 262 Chronic Active Epstein–Barr Virus Infection of T- and NK-cell Type, Cutaneous Form 264 Hydroa Vacciniforme-like Lymphoproliferative Disorder 264 Basic Principles of Disease Biology 264 Management of Disease in the Front Line 264 Severe Mosquito Bite Allergy 265 Epidemiology and Risk Factors 265 Basic Principles of Disease Biology 265 Management of Disease in the Front-Line 265 Future Directions 265 Must Reads 265 References 266 Part IV Treatment of the PTCL 269 20 Standard Front-line Therapies 271Raphael Koch and Lorenz Truempe Introduction 271 Initial Workup and Risk Stratification 271 Front-line Therapy 274 Front-line Treatment Approaches for Common Subtypes 274 Systemic Anaplastic Large-cell Lymphomas 276 Breast Implant-associated Anaplastic Large-cell Lymphomas 277 Enteropathy-associated T-cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-cell Lymphoma 277 Hepatosplenic T-cell Lymphoma 278 Extranodal natural killer/T-cell Lymphoma, Nasal Type 279 T-cell Prolymphocytic Leukemia 280 Adult T-Cell Leukemia/Lymphoma 280 Must Reads 281 References 281 21 Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab Vedotin 287Helen Ma and Owen A. O’Connor Introduction 287 Challenges in Developing New Drugs in Peripheral T-cell Lymphomas 288 Drugs Approved by the US Food and Drug Administration with an Indication in Relapsed/Refractory Peripheral T-cell Lymphoma 288 Pralatrexate 289 Pharmacology 289 Early-phase Data 289 Pivotal Data 289 Recent Developments 291 Histone Deacetylase Inhibitors (Including Romidepsin and Belinostat) 291 Pharmacology 291 Early Phase Data 292 Pivotal Data 292 Recent Developments 293 Drugs Approved by the US Food and Drug Administration But Without An Indication in Relapsed/Refractory Peripheral T-cell Lymphoma 294 Etoposide 294 Pharmacology 294 Clinical Experiences in Peripheral T-cell Lymphoma 294 Summary 294 Bortezomib 294 Pharmacology 294 Clinical Experiences in Peripheral T-cell Lymphoma 296 Recent Developments 296 Bendamustine 296 Pharmacology 296 Clinical Experience in Peripheral T-cell Lymphoma 296 Recent Developments 296 Gemcitabine 296 Pharmacology 296 Clinical Data 297 Recent Developments 297 Drugs Approved by International Regulatory Agencies, Not Including the United States, that Carry an Indication in Relapsed/Refractory Peripheral T-cell Lymphoma 297 Chidamide 297 Pharmacology 297 Early Phase Data 297 Pivotal Data 297 Recent Developments 297 Forodesine 297 Pharmacology 297 Early Phase Data 297 Pivotal Data 298 Recent Developments 298 Considerations in the Selection of Therapy 298 Treatment Goals 298 Aggressive Versus Indolent Disease 299 Transplant Eligible or Ineligible 299 Suitability for Chemotherapy 299 Conclusion 299 Must Reads 299 References 300 22 The Role of Autologous Stem-cell Transplantation in Peripheral T-cell Lymphomas 305Juan Alejandro Ospina-Idárraga, Rolando Humberto Martinez-Cordero, Leonardo José Enciso-Olivera and Henry Idrobo-Quintero Introduction 305 Autologous Stem-cell Transplantation in First Complete Remission 306 Autologous Stem-cell Transplantation in Relapsed/Refractory Disease 307 Interpretation of Available Literature 307 Identifying the Most Relevant Determinants for Survival among Patients with Peripheral T-cell Lymphoma Undergoing Autologous Stem-cell Transplantation 308 Status of Response Prior to Autologous Stem-cell Transplantation 309 Risk of Stage 310 Number of Prior Therapies and Refractory Disease 311 Autologous Stem-cell Transplantation on Specific Subtypes of Peripheral T-cell Lymphoma 311 Peripheral T-cell Lymphomas Not Otherwise Specified 311 Angioimmunoblastic T Cell Lymphoma 312 Anaplastic T Large-cell Lymphoma 312 Extranodal Natural Killer/T-cell Lymphoma, Nasal Type 313 The Role of Autologous Stem-cell Transplantation in Cutaneous T-cell Lymphomas 314 Must Reads 314 References 315 23 Allogeneic Stem-cell Transplantation 319Anna Dodero and Paolo Corradini Introduction 319 Allogeneic Stem-cell Transplantation for Relapsed and Refractory Disease (Focus on Nodal Hystotypes) 320 Allogeneic Stem-cell Transplantation as Consolidation of First Remission 322 Allogeneic Stem-cell Transplantation in Specific Subtypes 322 Cutaneous T-cell Lymphomas 322 Hepatosplenic T-cell Lymphomas 324 Extranodal Natural Killer/T-cell Lymphomas, Nasal Type 324 Adult T-cell Leukemia/Lymphoma 324 Future Directions 325 Must Reads 325 References 325 24 Emerging Immunotherapy Approaches in Peripheral T-cell Lymphomas 329Barbara Pro and Andrei Shustov Introduction 329 Monoclonal Antibody Therapy 329 Alemtuzumab 330 Mogamulizumab 330 Immunoconjugate-Based Therapy for Peripheral T-Cell Lymphoma 331 Brentuximab Vedotin 332 Cell-Mediated or Cellular Immunotherapy in Peripheral T-Cell Lymphoma 333 PD1–PD-L1 Checkpoint Inhibition 334 AFM13 – Targeted Natural Killer Cell Immunotherapy Facilitator 335 TTI-621 – Targeted Macrophage Immunotherapy Facilitator 335 4-1BB – Enabled Adoptive Therapy of Epstein–Barr Virus-Positive Malignancies 335 IPH4102 (Anti-KIR3DL2 Monoclonal Antibody) 336 Chimeric Antigen Receptor T-cell Therapy for Peripheral T-cell Lymphoma 336 Challenges and Future Directions 336 Must Reads 337 References 338 25 Emerging New Small Molecules in Peripheral T-cell Lymphomas 343Alessandro Broccoli and Pier Luigi Zinzani Introduction 343 Demethylating Agents 344 Janus-associated Kinase–Signal Transducers and Activators of Transcription and Spleen Tyrosine Kinase Inhibitors 345 Phosphatidylinositol 3-Kinase Inhibitors 345 Miscellaneous 347 Pro-apoptotic Small Molecules 347 Farnesyltransferase Inhibitors 347 Aurora Kinase Inhibitors 347 Conclusion 348 Must Reads 348 References 348 Part V Future Directions 351 26 The Value and Relevance of T-cell Lymphoma Registries 353Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok and Massimo Federico Introduction 353 Population-based Cancer Registries 353 Retrospective Studies 355 T-cell Lymphoma Registries 360 T-cell Project 1.0 360 COMPLETE 363 T-cell Project 2.0 363 Future Directions 364 Disclosures 364 Must Reads 364 References 365 27 Innovative Chemotherapy-free Approaches for the Treatment of Peripheral T-Cell Lymphoma 367Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto and Francesca Montanari Introduction 367 Targeting the Peripheral T-cell Lymphoma Epigenome 369 Romidepsin Plus Pralatrexate 370 Preclinical Rationale 370 Clinical Experience 370 Romidepsin Plus 5-Azacytidine 371 Preclinical Rationale 371 Clinical Experience 371 Romidepsin Plus Duvelisib 372 Preclinical Rationale 372 Clinical Experience 372 Romidepsin Plus Lenalidomide 373 Preclinical Rationale 373 Clinical Experience 373 Panobinostat and Bortezomib 373 Preclinical Rationale 373 Clinical Experience 374 A Glance at the Future: Building on the Active Doublets 374 Must Reads 375 References 375 28 Global Collaborations 379Dejan Radjeski, Eliza Hawke, Owen A. O’Connor, Pier Luigi Zinzani, Won Seog Kim and Enrica Marchi Introduction 379 The Global T-cell Lymphoma Consortium 380 The Mission 380 Structure 380 Organizational Features 380 Submission of Trial Concepts 381 Budget Negotiations 382 Institutional Review Board 383 Publications 383 Conclusion 384 Index 385
£148.45
John Wiley and Sons Ltd Discovering Precision Health
Book SynopsisTable of ContentsAbout the Authors ix Acknowledgments xi Introduction The Power of Precision Health 1 Chapter 1 The State of U.S. Health and Health Care Delivery 15 Chapter 2 There’s More to “Health” Than Health Care 33 Chapter 3 The Innovation and Disruption Powering Progress in Health 43 Chapter 4 Fundamental, Discovery‐Focused Research: The Foundation of Biomedical Breakthroughs 111 Chapter 5 Peering into the Future: Leveraging The Powers of Prediction to Help Prevent Illness 147 Chapter 6 Prevention as a Pathway to Health and Wellness 177 Chapter 7 Curing Disease with More Precise Medical Therapies 207 Conclusion Achieving Precision Health: The Opportunities—and Challenges—Ahead 237 Notes 243 Index 259
£28.76
John Wiley and Sons Ltd Genetic Disorders and the Fetus Diagnosis
Book SynopsisTable of ContentsPreface ix Acknowledgments xiii Contributors xv 1 Genetic Counseling: Preconception, Prenatal, and Perinatal 1Aubrey Milunsky and Jeff M Milunsky 2 PreimplantationGenetic Testing 102Anver Kuliev and Svetlana Rechitsky 3 Amniotic Fluid Constituents, Cell Culture, andNeural TubeDefects 140Daniel L Van Dyke and Aubrey Milunsky 4 Molecular Aspects of PlacentalDevelopment 197Wendy P Robinson and Deborah E McFadden 5 FetalOrigins of AdultHealth andDisease .214Michael G Ross and Mina Desai 6 Maternal SerumScreening for Chromosomal Abnormalities andNeural TubeDefects 240Howard Cuckle 7 Noninvasive Screening for AneuploidyUsing Cell-Free PlacentalDNA 301Lorraine Dugoff 8 Noninvasive Prenatal Diagnosis and Screening for Monogenic Disorders Using Cell-Free DNA 318Ignatia B Van den Veyver, Natalie Chandler and Lyn S Chitty 9 Amniocentesis, ChorionicVillus Sampling, and Fetal Blood Sampling .346Anthony O Odibo 10 PrenatalDiagnosis ofNeural TubeDefects 375Aubrey Milunsky 11 Prenatal Diagnosis of Chromosomal Abnormalities through Chorionic Villus Sampling and Amniocentesis 404Peter A Benn 12 PrenatalDiagnosis of Sex Chromosome Abnormalities 499Jeff M Milunsky 13 PrenatalDiagnosis of Chromosomal Abnormalities: FromKaryotype toMicroarray 547Brynn Levy 14 MolecularGenetics and PrenatalDiagnosis 572Jeff M Milunsky 15 PrenatalDiagnosis of Cystic Fibrosis 611Wayne W Grody 16 PrenatalDiagnosis and the Spectrumof Involvement fromFragile XMutations 629Randi J Hagerman and Paul J Hagerman 17 PrenatalDiagnosis of FetalMalformations byUltrasound .647Liesbeth van Leeuwen, Malou A Lugthart and Eva Pajkrt 18 Prenatal Diagnosis and Management of Abnormal Fetal Development in theThird Trimester of Pregnancy 701Roland Axt-Fliedner and AlineWolter 19 PrenatalDiagnosis by FetalMagnetic Resonance Imaging .760Nadine Girard and Kathia Chaumoitre 20 PrenatalDiagnosis of SkeletalDysplasias and Connective TissueDisorders 783Andrea Superti-Furga and Sheila Unger 21 PrenatalDiagnosis ofDisorders of CarbohydrateMetabolism 803Deeksha Sarihyan Bali, Stephanie L Austin and Priya S Kishnani 22 Disorders ofMetabolismof Amino Acids and Related Compounds 831Andrea Gropman, Georgianne Arnold and Jerry Vockley 23 The Mucopolysaccharidoses: Prenatal Diagnosis, Neonatal Screening and Emerging Therapies 868Lorne A Clarke 24 Prenatal Diagnosis of the Peroxisomal and Mitochondrial Fatty Acid Oxidation Deficiencies 890Ronald J.A.Wanders and Hans R.Waterham 25 PrenatalDiagnosis ofDisorders of LipidMetabolism 910James E Davison, Steven E Humphries, Bryan G.Winchester and Sara E Mole 26 PrenatalDiagnosis of Primary ImmunodeficiencyDiseases 982Jennifer M Puck 27 PrenatalDiagnosis of theHemoglobinopathies 1002John M Old and Jan Traeger-Synodinos 28 PrenatalDiagnosis of InheritedDisorders of Folate and CobalaminMetabolism .1035David S Rosenblatt andDavidWatkins 29 Fetal Surgery .1050Michael A Belfort and Alireza A Shamshirsaz 30 In Utero StemCell Transplantation, Enzyme Replacement, andGeneTherapy 1105Tippi C MacKenzie andMarisa E Schwab 31 MaternalGeneticDisordersThat Affect FetalHealth 1120Karin J Blakemore 32 Pregnancy Termination forGeneticDisorders: Indications and Complications 1158Lee P Shulman 33 Providing Supportive Psychosocial Care to Parents after Perinatal Loss 1179Marianne H Hutti 34 PrenatalDiagnosis of Fetal Infection 1197Marianne Leruez-Ville, Valentine Faure-Bardon and Yves G Ville 35 Medicolegal Aspects of PrenatalDiagnosis 1236EllenWright Clayton 36 Prenatal and PreimplantationDiagnosis: International Policy Perspectives 1250Minh Thu Minh Nguyen and Bartha Maria Knoppers 37 Ethical Issues in theDiagnosis andManagement ofGeneticDisorders in the Fetus 1267Frank A Chervenak and Laurence B McCullough Index 1294
£217.76
John Wiley & Sons Inc Applied Population Health Approaches for Asian
Book SynopsisAn insightful text exploring health disparities in Asian American populations In the newly revised Second Edition of Applied Population Health Approaches for Asian American Communities, a team of distinguished public health experts delivers a groundbreaking resource providing an in-depth examination of the soical, political, economic, and cultural forces shaping Asian American health today. Integrating up-to-date applied public health research for assessing health interventions and programs relevant to Asian American communities and other groups that have been historically marginalized, this book highlights the different frameworks, research designs, and other methodological considerations for reaching Asian American and other ethnic communities. In the latest edition of the book, readers will find contextual explorations of the Asian American population in the United States, as well as discussions of the measurement of health and risk across the lifespan in Asian American groupsTable of ContentsFigures and Tables viii Foreword: You Don’t Count If You Are Not Counted xMarjorie Kagawa-Singer The Editors xii The Contributors xiv Acknowledgments xxvii About the Companion Website xxviii Part One: Context One: The Asian American Population In The United States 3Winston Tseng, Lan N. Ðoàn Two: Health Framework For Understanding The Health And Health Disparities Of Asian American Populations 33Chau Trinh-Shevrin, Rachel Sacks, Simona C. Kwon, Matthew Lee, Deborah K. Min, Nadia S. Islam Three: The Health Of Asian American Communities 47Simona C. Kwon, Chau Trinh-Shevrin, Yousra Yusuf, Deborah K. Min, Rachel Sacks Part Two: Measures Four: Overview Of Methodologies Used To Generate Meaningful Data For Asian American Populations 69Riti Shimkhada, Ninez A. Ponce Five: Developing Research Interventions In Asian American Settings 85Shahmir H. Ali, Nadia S. Islam Part Three: Approaches Six: Integrating Systems Science With Community-Partnered Research To Serve Asian American Communities 109Stella S. Yi, Matthew Lee, Yan Li, Rienna G. Russo, Sara S. Metcalf Seven: Participatory Dissemination And Implementation Research In Community Settings 121Matthew Lee, Simona C. Kwon Eight: Community Engagement And Community-Based Participatory Research Approaches 133Perla Chebli, Simona C. Kwon Nine: Clinical-Community Linkage Strategies 151Hae-Ra Han Ten: Multilevel And Multisector Approaches To Health 163Marguerite J. Ro, Nadine L. Chan Part Four: Underrepresented Groups Eleven: Aging, Older Adults 179Tina R. Sadarangani, Sarah M. Miner, Larissa R. Burka Twelve: Multiple Marginalization Among Asian American Populations 191Sahnah Lim, John J. Chin, Christina Y. Lee Part Five: Policy Thirteen: Federal Landscape For Health Research 205Lan N. Ðoàn, Chandak Ghosh, Kathy Ko Chin, Juliet K. Choi Afterword: Where to Next? 227Shobha Srinivasan, Rina Das Appendix: Case Studies Case 1: Reach Far: Culturally Adapted, Evidence-Based Hypertension Control Programs Among Asian Americans In New York And New Jersey 231Deborah K. Min Case 2: An Integrative Data Approach To Study Lung Cancer Among Aa And Nh/Pi Females 237Scarlett Lin Gomez, Iona Cheng, Mindy C. DeRouen Case 3: Using Data To Define And Explore Health Status In Asian American Ethnic Enclaves In New York City 241Sungwoo Lim, Liza King Case 4: The Dream Initiative: An Iterative Approach To Addressing South Asian Health Needs In New York City 245Sadia Mohaimin, Jennifer Zanowiak, Shahmir H. Ali, Shinu Mammen, MD Taher, Gulnahar Alam, MD Jalal Uddin, Sidra Zafar, Sabiha Sultana, Nadia S. Islam Case 5: Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias 255Jennifer A. Wong Case 6: Manhattan Detention Center 261Yi-Ling Tan Case 7: Forging Partnerships 263Lan N. Ðoàn, Stella S. Yi, Jennifer A. Wong, Matthew K. Chin, Simona C. Kwon Case 8: Hope Clinic: Houston’s Medical Home For Asian Americans 269Andrea Caracostis Case 9: The Chinatown-International District Of Seattle/King County 273Marguerite J. Ro, Nadine L. Chan Case 10: Path For Women: Improving Access To Breast And Cervical Cancer Screening For Thai Women In Los Angeles 277Mary Anne Foo Case 11: Partnering With Older Adult Refugees For Better Home Health Care Delivery 281Tina R. Sadarangani, Sarah M. Miner, Larissa R. Burka Case 12: India Home 285Selvia Sikder, Shaaranya Pillai Case 13: Asian Immigrant Women Engaging In Sex Work In Massage Parlors 289John J. Chin, Lois M. Takahashi Index 293
£63.00
John Wiley & Sons Inc DNA Origami
Book SynopsisDNA ORIGAMI Discover the impact and multidisciplinary applications of this subfield of DNA nanotechnology DNA origami refers to the technique of assembling single-stranded DNA template molecules into target two- and three-dimensional shapes at the nanoscale. This is accomplished by annealing templates with hundreds of DNA strands and then binding them through the specific base-pairing of complementary bases. The inherent properties of these DNA moleculesmolecular recognition, self-assembly, programmability, and structural predictabilityhas given rise to intriguing applications from drug delivery systems to uses in circuitry in plasmonic devices. The first book to examine this important subfield, DNA Origami brings together leading experts from all fields to explain the current state and future directions of this cutting-edge avenue of study. The book begins by providing a detailed examination of structural design and assembly systems and their applicatioTable of ContentsList of Contributors xiii Preface xvii 1 DNA Origami Technology: Achievements in the Initial 10 Years 1 Masayuki Endo 1.1 Introduction 1 1.1.1 DNA Nanotechnology Before the Emergence of DNA Origami 3 1.2 Two- Dimensional DNA Origami 3 1.3 Programmed Arrangement of Multiple DNA Origami Components 6 1.4 Three- Dimensional DNA Origami Structures 9 1.5 Modification and Functionalization of 2D DNA Origami Structures 11 1.5.1 Selective Placement of Functional Nanomaterials 11 1.5.2 Selective Placement of Functional Molecules and Proteins via Ligands 13 1.5.3 Distance- Controlled Enzyme Reactions and Photoreactions 13 1.6 Single- Molecule Detection and Sensing using DNA Origami Structures 14 1.6.1 Single- Molecule RNA Detection 14 1.6.2 Single- Molecule Detection of Chemical Reactions 14 1.6.3 Single- Molecule Detection using Mechanical DNA Origami 14 1.6.4 Single- Molecule Sensing using Mechanical DNA Origami 14 1.7 Application to Single Biomolecule AFM Imaging 16 1.7.1 High- Speed AFM- Based Observation of Biomolecules 16 1.7.2 Visualization of DNA Structural Changes in the DNA Nanospace 18 1.7.3 Visualization of the Reaction Events of Enzymes and Proteins in the DNA Nanospace 18 1.8 Single- Molecule Fluorescence Studies 19 1.8.1 Nanoscopic Ruler for Single- Molecule Imaging 19 1.8.2 Kinetics of Binding and Unbinding Events and DNA- PAINT 21 1.8.3 DNA Barcode Imaged by DNA- PAINT 21 1.9 DNA Molecular Machines 22 1.9.1 DNA Assembly Line Constructed on the DNA Origami 22 1.9.2 DNA Spider System Constructed on the DNA Origami 22 1.9.3 DNA Motor System Constructed on the DNA Origami 24 1.10 Selective Incorporation of Nanomaterials and the Applications 24 1.10.1 DNA Origami Plasmonic Structure with Chirality 24 1.10.2 Surface- Enhanced Fluorescence by Gold Nanoparticles and DNA Origami Structure 26 1.10.3 Placement of DNA Origami onto a Fabricated Solid Surface 26 1.11 Dynamic DNA Origami Structures Responsive to External Stimuli 27 1.11.1 DNA Origami Structures Responsive to External Stimuli 27 1.11.2 Stimuli- Responsive DNA Origami Plasmonic Structures 27 1.11.3 Photo- Controlled DNA Origami Plasmonic Structures 27 1.12 Conjugation of DNA Origami to Lipid 29 1.12.1 DNA Origami Channel with Gating 29 1.12.2 DNA Origami Templated Synthesis of Liposomes 29 1.13 DNA Origami for Biological Applications 29 1.13.1 Introduction of DNA Origami into Cells and Functional Expression 29 1.13.2 Drug Release Using the Properties Characteristic for DNA Origami 31 1.13.3 DNA Origami Structures Coated with Lipids and Polymers 32 1.13.4 Nanorobot with Dynamic Mechanism 32 1.13.5 Nanorobot Targeting Tumor In Vivo 32 1.14 Conclusions 33 References 34 2 Wireframe DNA Origami and Its Application as Tools for Molecular Force Generation 41 Marco Lolaico and Björn Högberg 2.1 Introduction 41 2.2 Pre- Origami Wireframe DNA Nanostructures 42 2.3 Hierarchical DNA Origami Wireframe 43 2.4 Entire DNA Origami Design 45 2.5 DNA Origami Wireframe as Tools for Molecular Force Application 50 2.5.1 Introduction 50 2.5.2 Results and Discussion 51 2.6 Conclusions 54 2.6.1 Materials and Methods 54 References 55 3 Capturing Structural Switching and Self- Assembly Events Using High- Speed Atomic Force Microscopy 59 Yuki Suzuki 3.1 Introduction 59 3.2 DNA Origami Nanomachines 60 3.3 Ion- Responsive Mechanical DNA Origami Devices 60 3.4 Photoresponsive Devices 62 3.5 Two- Dimensional Self- Assembly Processes 64 3.6 Sequential Self- Assembly 66 3.7 Photostimulated Assembly and Disassembly 67 3.8 Conclusions and Perspectives 69 References 69 4 Advancement of Computer- Aided Design Software and Simulation Tools for Nucleic Acid Nanostructures and DNA Origami 75 Ibuki Kawamata 4.1 Introduction 75 4.2 General- Purpose Software 76 4.3 Software for Designing Small DNA Nanostructures 78 4.4 Software for Designing DNA Origami 81 4.5 Software for Designing RNA Nanostructures 84 4.6 Software for Designing Base Sequence 84 4.7 Software for Simulating Nucleic Acid Nanostructures 85 4.8 Summary and Future Perspective 86 References 87 5 Dynamic and Mechanical Applications of DNA Nanostructures in Biophysics 101 Melika Shahhosseini, Anjelica Kucinic, Peter Beshay, Wolfgang Pfeifer, and Carlos Castro 5.1 Introduction 101 5.1.1 What Makes DNA a Good Material for Dynamic Applications 101 5.1.2 Rupture Forces 103 5.2 Applications 105 5.2.1 Force Spectroscopy 105 5.2.1.1 Utilizing the Stiffness of DNA for Force Spectroscopy 105 5.2.1.2 Applications that Utilize Rupture Forces 107 5.2.2 DNA Devices that Probe and Control DNA–DNA Interactions 108 5.2.2.1 Detection 108 5.2.2.2 Modulation 111 5.2.3 DNA Devices that Respond to Biomolecules 111 5.2.4 DNA Devices to Study Biological Molecular Motors 116 5.2.5 DNA Walkers 116 5.2.6 DNA Computing 119 5.3 Tools for Quantifying DNA Devices and their Functions 120 5.4 Modeling and Analysis 123 5.5 Conclusion 124 References 124 6 Plasmonic Nanostructures Assembled by DNA Origami 135 Sergio Kogikoski, Jr, Anushree Dutta, and Ilko Bald 6.1 Introduction 135 6.2 Optical Properties of the DNA Origami- Based Plasmonic Nanostructures 135 6.3 Nanoparticle Functionalization with DNA 138 6.4 DNA Origami- Based Plasmonic Assemblies 140 6.5 Surface- Enhanced Raman Scattering (SERS) and Other Plasmonic Effects 143 6.6 Conclusion 152 Acknowledgments 152 References 152 7 Assembly of Nanoparticle Superlattices Using DNA Origami as a Template 155 Sofia Julin, Petteri Piskunen, Mauri A. Kostiainen, and Veikko Linko 7.1 Introduction 155 7.2 Gold Nanoparticles 156 7.2.1 Oligonucleotide- Modified AuNPs 156 7.2.2 Cationic AuNPs 158 7.3 Formation of DNA Origami- Assisted Superlattices 158 7.3.1 Superlattices Formed by Oligonucleotide- Functionalized AuNPs 159 7.3.2 Superlattice Formed by Cationic AuNPs 160 7.4 Characterization of Assemblies 160 7.4.1 Electron Microscopy 161 7.4.2 Small- Angle X- ray Scattering 161 7.5 Conclusions and Future Perspectives 162 Acknowledgments 164 References 164 8 Mechanics of DNA Origami Nanoassemblies 167 Deepak Karna, Jiahao Ji, and Hanbin Mao 8.1 Introduction 167 8.2 Analytical Tools to Investigate Mechanical Properties of Nanoassemblies 168 8.2.1 Optical Tweezers 168 8.2.2 Magnetic Tweezers 169 8.2.3 Atomic Force Microscopy (AFM) 169 8.3 Mechanical Strength of DNA Origami Structures 171 8.4 Applications of Origami Nanostructures by Exploiting their Mechanical Strength 173 8.5 Mechanochemical Properties of DNA Origami 175 8.6 Conclusions 177 References 177 9 3D DNA Origami as Single- Molecule Biophysical Tools for Dissecting Molecular Motor Functions 181 Mitsuhiro Iwaki 9.1 Introduction 181 9.2 DNA Origami Nanospring 181 9.2.1 Design of DNA Origami Nanospring 181 9.2.2 Nanospring Mechanical Properties 182 9.2.3 Application to a Myosin VI Processive Motor 183 9.3 DNA Origami Thick Filament Mimicking Muscle Structure 187 9.3.1 Mystery of Muscle Contraction 187 9.3.2 Design of a DNA Origami- Based Thick Filament 188 9.3.3 High- speed AFM Observation of Force Generation by Myosin 189 9.3.4 High- Speed Darkfield Imaging of Force Generation by Myosin 189 9.4 Perspective 193 References 193 10 Switchable DNA Origami Nanostructures and Their Applications 197 Jianbang Wang, Michael P. O’Hagan, Verena Wulf, and Itamar Willner 10.1 Introduction 197 10.2 Switchable Machines Constructed from DNA Origami Scaffolds 198 10.2.1 Chemical Triggers for Origami Scaffolds 198 10.2.1.1 Triggering Origami Devices with Strand Displacement Reactions 198 10.2.1.2 Triggering Origami with Ion Concentration 200 10.2.1.3 Triggering Origami with Molecular Species 202 10.2.2 Physical Triggers for Origami Scaffolds 204 10.2.2.1 Triggering Origami with Temperature 204 10.2.2.2 Triggering Origami with Electric Fields 206 10.2.2.3 Triggering Origami with Magnetic Fields 206 10.2.2.4 Triggering Origami with Light 208 10.3 DNA Origami Scaffolds for Defined Mechanical Operations 210 10.3.1 Origami Scaffolds that Dictate the Motility of Elements 212 10.3.2 Engineering Mechanical Functions of Origami Tiles 218 10.4 Switchable Interconnected 2D Origami Assemblies 218 10.5 Dynamic Triggered Switching of Origami for Controlled Release 223 10.6 Switchable Plasmonic Phenomena with DNA Origami Scaffolds 227 10.7 Origami- Guided Organization of Nanoparticles and Proteins 234 10.8 Conclusions and Perspectives 238 References 239 11 The Effect of DNA Boundaries on Enzymatic Reactions 241 Richard Kosinski and Barbara Saccà 11.1 Introduction 241 11.2 DNA- Scaffolded Single Enzymes 242 11.3 DNA- Scaffolded Enzyme Cascades 247 11.4 On the Proximity Model and Other Hypotheses 250 11.5 Conclusions 254 Acknowledgments 256 References 256 12 The Methods to Assemble Functional Proteins on DNA Scaffold and their Applications 261 Eiji Nakata, Shiwei Zhang, Huyen Dinh, Peng Lin, and Takashi Morii 12.1 Introduction 261 12.2 Overview of the Methods for Arranging Proteins on DNA Scaffolds 262 12.2.1 Reversible Conjugation between Protein and DNA 263 12.2.1.1 Biotin- Avidin 264 12.2.1.2 Antibody- Antigen 264 12.2.1.3 Ni- NTA- Hexahistidine 266 12.2.1.4 Aptamers 266 12.2.1.5 Apo- Protein Reconstitution by the Prosthetic Group 266 12.2.2 Irreversible Conjugation between Protein and DNA 266 12.2.2.1 Chemical Crosslinking of Protein and DNA via Cross- Linker 267 12.2.2.2 Crosslinking of Genetically Fused Protein with Chemically Modified DNA 267 12.2.2.3 Covalent Conjugation of Genetically Modified Proteins to Unmodified DNA 269 12.2.2.4 Applications of the Enzyme Assembled DNA Scaffolds 269 12.3 DNA- Binding Adaptor for Assembling Proteins on DNA Scaffold and its Application 270 12.3.1 DNA- Binding Adaptor for Reversible Assembly of Proteins via Noncovalent Interactions 270 12.3.2 Modular Adaptors for Covalent Conjugation of Genetically Modified Proteins to Chemically Modified DNA 272 12.3.3 Application of DNA- Binding Adaptors for Assembling Proteins on DNA Scaffolds 275 12.3.3.1 Assembling Protein of Interest on DNA Scaffold in Cell 275 12.3.3.2 Enzymatic Reaction System on a DNA Scaffold 275 12.4 Summary 278 References 278 13 DNA Origami for Synthetic Biology: An Integrated Gene Logic- Chip 281 Hisashi Tadakuma 13.1 Introduction 281 13.2 Biomolecule Integration on DNA Nanostructure 281 13.2.1 Nature Uses “Reaction Field” to Overcome the Cross- Talk Problem 281 13.2.2 Synthetic Biology Approach 282 13.2.3 DNA–Protein Complex 282 13.2.4 Enzymatic Reaction on DNA Origami for Low- Molecular- Weight Substrate 284 13.3 Gene Expression Control Using DNA Nanostructure 285 13.3.1 Enzymatic Reaction on DNA Origami for High- Molecular- Weight Substrate 285 13.3.2 Resolving Synthetic Biology Limitation by DNA Origami- Based Nano- Chip 286 13.3.3 Unique Characters of the Nano- Chip 288 13.3.4 Limitation of the Nano- Chip 292 13.4 Summary and Perspective 292 Acknowledgments 293 References 293 14 DNA Origami for Molecular Robotics 297 Akinori Kuzuya 14.1 DNA Origami as a Stage for DNA Walkers and Robotic Arms 297 14.2 Nanomechanical DNA Origami 298 14.3 DNA Origami Used in Combination with Molecular Motors 300 14.4 Future Perspective 301 References 303 15 DNA origami Nanotechnology for the Visualization, Analysis, and Control of Molecular Events with Nanoscale Precision 305 Xiwen Xing and Masayuki Endo 15.1 Introduction 305 15.2 Designing of DNA Origami Frames for the Direct Observation of DNA Conformational Changes 308 15.3 Direct Observation of DNA Structural Changes in the DNA Origami Frame 308 15.3.1 G- Quadruplex Formation and Disruption 308 15.3.2 G- Quadruplex Formation by the Assembly of Four DNA Strands 309 15.3.3 Light- Induced Hybridization and Dehybridization of the Photoswitchable DNA Strands 309 15.3.4 Direct Observation of B–Z Transition in the Equilibrium State 312 15.3.5 Topological Control of G- Quadruplex and I- Motif Formation in the dsDNA 314 15.4 Direct Observation and Regulation of Enzyme Reactions in the DNA Origami Frame 315 15.4.1 Direct Observation and Regulation of Cre- Mediated DNA Recombination in the DNA Origami Frame 315 15.4.2 Holiday- Junction Resolution Mediated by DNA Resolvase 317 15.4.3 DNA Oxidation in the DNA Demethylation Process Mediated by TET Enzyme 317 15.4.4 Searching and Recognition of Target Sites by using Photoresponsive Transcription Factor GAL 4 319 15.5 Direct Observation of a Mobile DNA Nanomachine using DNA Origami 321 15.5.1 A DNA Linear Motor System Created on a DNA Origami System 321 15.5.2 Single- Molecule Operation of DNA Motor by using Programmed Instructions 321 15.5.3 Photo- Controlled DNA Motor System Constructed on DNA Origami 324 15.5.4 Photo- Controlled DNA Rotator System Constructed on DNA Origami 324 15.6 Limitations of AFM Imaging and Comparison with other Imaging Techniques 326 15.7 Conclusions and Perspectives 326 References 327 16 Stability and Stabilization of DNA Nanostructures in Biomedical Applications 333 Soumya Chandrasekhar, Praneetha Sundar Prakash, and Thorsten- Lars Schmidt 16.1 Threats for DNA Nanostructures 333 16.1.1 Errors from Nanostructure Synthesis 334 16.1.1.1 Missing Strands 334 16.1.1.2 Oligonucleotide Synthesis Errors 335 16.1.2 Denaturation of DNA Duplexes 336 16.1.2.1 Melting 336 16.1.2.2 The Role of Cations 336 16.1.2.3 Influence of pH on Duplex Stability 337 16.1.3 Backbone Cleavage 337 16.1.3.1 Acid- Induced Depurination 337 16.1.3.2 Base- Induced Cleavage of RNA 338 16.1.3.3 Enzymatic Digest 338 16.1.4 Chemical Damage at the Nucleobases 339 16.1.4.1 Ultraviolet Radiation 339 16.1.4.2 Radiative and Oxidative DNA Damage 340 16.1.4.3 Deamination 340 16.1.5 DNA Structures for Biological Applications 341 16.1.5.1 Bioimaging 341 16.1.5.2 Biosensing 341 16.1.5.3 Computing 341 16.1.5.4 Single- Molecule Biophysics and Mechanobiology 343 16.1.5.5 Drug Delivery and Gene Therapy 343 16.1.6 In vitro and In vivo Degradation and Clearance of DNA Structures 343 16.1.6.1 Common in vitro and in vivo Stability Assays 344 16.1.6.2 Degradation of DN in in vitro and in vivo 344 16.1.6.3 Low Mg2+ Conditions 346 16.1.6.4 Presence of Nucleases 346 16.1.6.5 Cellular Uptake and Clearance of DNs 347 16.1.6.6 Immune Response 348 16.2 Strategies to Protect DNA Origami Structures 349 16.2.1 Stabilization by Design 349 16.2.2 Stabilization by Covalent Strategies 351 16.2.2.1 Enzymatic Ligation 351 16.2.2.2 Chemical Crosslinking 352 16.2.2.3 Photo Crosslinking 354 16.2.2.4 Base Analogues and Backbone Modification 356 16.2.3 Stabilization by Non- Covalent Strategies and Additives 356 16.2.3.1 Inorganic Materials 356 16.2.3.2 Proteins 358 16.2.3.3 Polymer, Peptides, and Polycation Coatings 358 References 362 17 DNA Nanostructures for Cancer Diagnosis and Therapy 379 Zhe Li and Yonggang Ke 17.1 Introduction 379 17.2 DNA Nanostructure- Based Diagnostics 380 17.2.1 Nucleic Acid Detection 380 17.2.2 Protein and Exosome Detection 382 17.2.3 Tumor Cell Detection 384 17.2.4 Imaging 385 17.3 DNA Nanostructure- Based Drug Delivery 386 17.3.1 Small Molecules 386 17.3.1.1 Doxorubicin 386 17.3.1.2 Platinum- Based Drugs 387 17.3.2 Biologics 389 17.3.2.1 CpG 389 17.3.2.2 RNA 390 17.3.2.3 Protein 392 17.3.3 Inorganic Nanoparticles 393 17.4 Challenges and Prospects 394 17.4.1 Stability 394 17.4.1.1 Nucleases 395 17.4.1.2 Mg2+ 395 17.4.1.3 Shape and Superstructure of DNA Nanostructures 396 17.4.2 Drug Loading Efficiency 396 17.4.3 Drug releasing efficiency 397 17.4.4 Cell Internalization 398 References 400 Index 411
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John Wiley & Sons Inc Keto Desserts for Dummies
Book SynopsisFrom the bestselling authors of Keto DietForDummies Keto Desserts for Dummiesdebunks the rumorthat you needto give up your favorite sweet treats when you go keto.Rami and Vicky Abrams provide in-depth detailson how to maintain the popular low-carb, low-sugar diet whilestillenjoying delicious desserts and treats. Created by the founders of the wildly popular Tasteaholics.com,along with the Total Keto Diet App, KetoDessertsForDummies explainshow to swap outstandard bakingingredients, including sugar, flour, and milk,for keto-friendly ones. You'll maintain theflavor of your favorite desserts while making them compatible with theketodiet. This handy guideshowsyou how to: Make delicious desserts while sticking to the keto regimenChoose keto-friendly versions of your favorite desserts so you don't ruin your daily macrosIncorporate keto-approved desserts into your overall keto meal plans Keto DessertsForDummiesincludesmore than 150easy-to-follow andtastyrecipes sure to make your taste buds light up. All the recipes are designed to besimpleand easy to follow,ensuring that anyone can make them, evenpeople new to the keto program.
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John Wiley and Sons Ltd Clinical Pain Management
Book SynopsisClinical Pain Management Pain has many dimensions; biological, psychological and social. All of these warrant attention in clinical management and research. Despite advances in pain management and understanding, chronic pain in particular continues to be a major health concern. Many challenging problems persist in our efforts to understand and manage chronic pain. This revised and updated second edition of Clinical Pain Management: A Practical Guide draws attention to the challenges that exist for people living with chronic pain conditions, for the clinician trying to provide effective management of the patient's pain, for the scientist seeking to unravel the mechanisms underlying pain, and for society as a whole. This book offers the opportunity for clinicians to improve their knowledge about pain and apply that knowledge for the benefit of their patients. This second edition has built upon the first edition, which was distinctive in its integration of the clinical, psychosocial and basic science topics related to the different types of pain and their management. With up-to-date information throughout the 44 chapters of this second edition, this book provides a valuable resource about pain from a variety of perspectives. Clinical Pain Management: A Practical Guide, Second Edition, will be particularly valuable not only for clinicians to help them assist with their patients experiencing an acute pain or suffering from chronic pain, but also for scientists who wish to gain more insights into these pain conditions and their underlying processes.Table of ContentsForeword/ preface Foreword to first edition Part 1: Basic Understanding of Pain Medicine 1 The challenge of pain: a multidimensional phenomenon 2 Epidemiology and economics of recurrent and chronic non-cancer pain 3 Basic mechanisms and pathophysiology 4 Psychosocial Aspects of Pain 5 Identification of risk and protective factors in the transition from acute to chronic post-surgical pain 6 Placebo/nocebo: a two-sided coin in the clinician’s hand 7 Knowledge transfer to patients experiencing pain and poor sleep and sleep disorder Part 2: Assessment of Pain 8 Clinical assessment in adult patients 9 Measurement and assessment of pain in pediatric patients 10 Laboratory investigations, imaging, and neurological assessment in pain management 11 Psychological assessment of persons with chronic pain Part 3: Management 12 Introduction to management 13 Managing chronic pain in primary care 14 Medical nutrition therapy for chronic pain management 15 Physical therapy and rehabilitation Part 4: Pharmacotherapy 16 Antidepressant analgesics in the management of chronic pain 17 Anticonvulsants in the management of chronic pain 18 Opioids 19 Topical analgesics 20 Cannabinoids and other agents 21 Combined pharmacotherapy for chronic pain management Part 5: Interventional 22 Diagnostic and therapeutic blocks 23 Neuromodulation therapy 24 Neurosurgical management of pain Part 6: Psychological 25 Pain self-management: theory and process for clinicians 26 Psychological interventions: a focus on cognitive behavioral therapy 27 Pain catastrophizing and fear of movement: detection and intervention Part 7: Complementary Therapies 28 Complementary and integrative health approaches for pain relief Part 8: Specific Clinical States 29 Low Back Pain 30 Fibromyalgia syndrome and myofascial pain syndromes 31 Clinical pain management in the rheumatic diseases 32 Headache 33 Orofacial Pain 34 Visceral Pain 35 Pelvic and Urogenital Pain 36 Neuropathic Pain 37 Complex Regional Pain Syndrome 38 Cancer Pain 39 Pain and Addiction Part 9: Special Populations 40 Pain in older adults: a brief clinical 41 Pain in Children 42 Pain in individuals with intellectual disabilities 43 Pain and Psychiatric Illness 44 Basic principles in acute and perioperative pain in patients with opiod tolerance Subject index
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John Wiley and Sons Ltd Demystifying Research for Medical and Healthcare
Book SynopsisDEMYSTIFYING RESEARCH FOR MEDICAL & HEALTHCARE STUDENTS All healthcare students need to understand research methods to be able to understand research articles and to actively engage in research where necessary. Most clinical programs include research training within their courses, and many students are required to undertake an assessed research projectboth at undergraduate and postgraduate levels. Breaking down the jargon barriers of research methods, and designed for those new to the world of research, Demystifying Research is a straightforward and highly accessible guide to fundamental research methods, approaches, and skills. This student-friendly resource describes quantitative and qualitative research approaches, mixed research methods, research ethics and governance, research skills and more. Step-by-step, students learn to appraise research in scholarly articles, design a project, and conduct research in the lab, in clinical practice, and other real-life situations. Technical jaTable of ContentsPreface vi About the Companion Website viii 1 Introduction: What is ‘Research’? 1 2 Experimental Quantitative Approaches: Laboratory Experiments 14 3 Experimental Quantitative Approaches: Real- Life (Field) Experiments 27 4 Experimental Quantitative Approaches: Non- randomised Clinical Trials 39 5 Experimental Quantitative Approaches: Randomised Control Trials 48 6 Observational Quantitative Approaches: Cohort Studies 66 7 Observational Quantitative Approaches: Case- Control Studies 80 8 Observational Quantitative Approaches: Cross- Sectional Studies (Surveys) 87 9 Observational Quantitative Approaches: Cross- Sectional Studies – Other Types of Study 100 10 Qualitative Ethnographic Approaches: Using Participant Observation 108 11 Qualitative Ethnographic Approaches: Using Interviews and Focus Groups 124 12 Qualitative Ethnographic Approaches: Autoethnography 144 13 Qualitative Approaches: Phenomenology 157 14 Qualitative Approaches: Grounded Theory 175 15 Mixed Methods: Case Study Methods 186 16 Mixed Methods: Policy Analysis 200 17 Mixed Methods: Multi- Stage Studies 216 18 Research Ethics and Governance: The Need for Regulation 223 19 Research Ethics and Governance: Regulations, Approvals, and Permissions 237 Appendices 258 Appendix A: Research Skills Obtaining Informed Consent 258 Appendix B: Research Skills Searching the Literature 268 Appendix C: Research Skills Laboratory Safety 276 Appendix D: Research Skills Interviewing 281 Appendix E: Research Skills Focus Groups 294 Appendix F: Research Skills Analysing Qualitative Data 303 Appendix G: Research Skills Writing Research Reports 314 Postscript 320 Index 321
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John Wiley and Sons Ltd A Companion to Medical Anthropology
Book SynopsisThe fully revised new edition of the defining reference work in the field of medical anthropology A Companion to Medical Anthropology, Second Edition provides the most complete account of the key issues and debates in this dynamic, rapidly growing field. Bringing together contributions by leading international authorities in medical anthropology, this comprehensive reference work presents critical assessments and interpretations of a wide range of topical themes, including global and environmental health, political violence and war, poverty, malnutrition, substance abuse, reproductive health, and infectious diseases. Throughout the text, readers explore the global, historical, and political factors that continue to influence how health and illness are experienced and understood. The second edition is fully updated to reflect current controversies and significant new developments in the anthropology of health and related fields. More than twenty new and revised articles address research areas including war and health, illicit drug abuse, climate change and health, colonialism and modern biomedicine, activist-led research, syndemics, ethnomedicines, biocommunicability, COVID-19, and many others. Highlighting the impact medical anthropologists have on global health care policy and practice, A Companion to Medical Anthropology, Second Edition: Features specially commissioned articles by medical anthropologists working in communities worldwideDiscusses future trends and emerging research areas in the fieldDescribes biocultural approaches to health and illness and research design and methods in applied medical anthropology Addresses topics including chronic diseases, rising levels of inequality, war and health, migration and health, nutritional health, self-medication, and end of life care Part of the acclaimed Wiley Blackwell Companions to Anthropology series, A Companion to Medical Anthropology, Second Edition, remains an indispensable resource for medical anthropologists, as well as an excellent textbook for courses in medical anthropology, ethnomedicine, global health care, and medical policy.Table of ContentsNotes on Contributors ix Introduction 1 Part I: Theories, Applications, and Methods 7 1 Re/Inventing Medical Anthropology: Definitional Struggles and Key Debates (Or: Answering the Cri Du Coeur) 9Elisa J. Sobo 2 Critical Biocultural Approaches to Health and Illness 26Thomas L. Leatherman and Alan H. Goodman 3 Applied Medical Anthropology: Praxis, Pragmatics, Politics, and Promises 49Robert T. Trotter, II 4 Research Design and Methods in Medical Anthropology 67Clarence C. Gravlee Part II: Contexts and Conditions 93 5 Culture and the Stress Process 95William W. Dressler 6 Global Health 109Craig R. Janes, Jennifer A. Liu, and Kitty K. Corbett 7 Syndemics in Global Health 126Merrill Singer and Emily Mendenhall 8 The Ecology of Health and Disease 145Patricia K. Townsend 9 The Medical Anthropology of Water and Sanitation 160E. Christian Wells and Linda M. Whiteford 10 Medical Anthropology of Political Violence and War 180Barbara Rylko-Bauer 11 Medical Anthropology at the End of Life 198Ron Barrett Part III: Health and Behavior 213 12 The Anthropology of Reproduction 215Elise Andaya and Mounia El Kotni 13 Anthropological Approaches to Migration and Health 230Heide Castañeda 14 Current Approaches to Nutritional Health in Medical Anthropology 245Deven Gray, David Himmelgreen, Nancy Romero-Daza, and Charlotte Noble 15 Cancers’ Multiplicities: Anthropologies of Interventions and Care 260Lenore Manderson 16 Anthropology and the Study of Illicit Drug Use 275J. Bryan Page 17 Revisiting Generation Rx: Emerging Trends in Pharmaceutical Enhancement, Lifestyle Regulation, Self-Medication, and Recreational Drug Use 295Gilbert Quintero and Mark Nichter Part IV: Healthwork: Care, Treatment, and Communication 315 18 Ethnomedicines: Traditions of Medical Knowledge 317Marsha B. Quinlan 19 Medical Pluralism: An Evolving and Contested Concept in Medical Anthropology 342Hans A. Baer 20 Biotechnologies of Care 358Ruth Fitzgerald and Julie Park 21 Medicine: Colonial, Postcolonial, or Decolonial? 373César Ernesto Abadía-Barrero 22 The Politics of Communicability 388Charles L. Briggs Part V: The Road Ahead 407 23 When Workers’ Health is Public Health: The Structural Complicity of State Public Health Policies on Covid-19 Spread in Meat-Processing Plants and Minority Communities 409Sandy Smith-Nonini 24 Climate Change and Health: Anthropology and Beyond 429Merrill Singer, Eleanor Shoreman-Ouimet, and Ashley L. Graham Index 442
£134.06
