Medical specialties, branches of medicine Books

Book SynopsisThe first book in a new series from the World Psychiatric Association, Schizophrenia: current science and clinical practice presents recent information on the diagnosis, neurobiological foundations, and management of schizophrenia. It evaluates the findings obtained with modern techniques like magnetic resonance imaging, genetics and network analyses. The book reviews the importance of neurocognitive functioning in schizophrenia and its predictive value for functional capacity. It covers the key areas of early recognition, prevention, rehabilitation and stigma. There is also a critical discussion of diagnostic classification and the revision of the two major international systems. Written by experts in the field who have a track record of being engaging authors, this book provides a rapid overview of the current state of the art in schizophrenia research and clinical management. It will be invaluable to all psychiatrists, psychologists, neuropharmacologists, researchers in pTrade Review“Professor Gaebel and contributing authors are to be congratulated for this outstanding text.” (Journal of Clinical Psychiatry, 6 June 2012) "Nonetheless, Schizophrenia: Current Science and Clinical Practice will be an asset to those who are seeking a current and sophisticated synthesis of the field, combined with stimulating discussions of some pivotal controversies in both research and treatment. Gaebel has assembled a distinguished group of contributors who are more than up to the task of grappling with the challenge of discerning the implications of cutting-edge research for clinical intervention." (PsycCRITIQUES, 11 January 2012) "I am not in a position to comment on most chapters, as I am not an expert in those fields, but all I can say is that I learnt a lot and that the book provided me with a good overview on different aspects of what we commonly call schizophrenia." (Acta Psychiatr Scandinavica, 2012) "The first chapter is an excellent and factual review of the diagnosis and classification systems that highlights the major validity issues. . .This new book is useful and current." (Doody's, 30 September 2011) "The book will be of interest to psychiatrists, psychologists, neuropharmacologists, researchers in psychiatry and psychopharmacology, and clinical and behavioral neuroscientists." (Book News, 1 August 2011) Table of ContentsList of Contributors. Preface. 1 Diagnosis and revision of the classification systems (Assen Jablensky). Introduction. Origin and evolution of the concept of schizophrenia. Kraepelin's 'clinical forms'. Bleuler's 'group of schizophrenias'. Leonhard's 'endogenous psychoses'. Classification of psychoses in French psychiatry. Other post-Kraepelinian and post-Bleulerian subtypes and dichotomies. The schizophrenia spectrum concept. Statistically derived clusters and symptom dimensions. Schizophrenia in ICD-10 and DSM-IV. Origins of the two classifications. Both DSM-IV and ICD-10 are descendants of the Kraepelinian nosology. Criteria for assessing the diagnostic classification of schizophrenia. Positive impact and unintended adverse effects. Clinical relevance and cognitive ease of use. Utility in research. Reliability. Concepts of validity. Predictive validity: course and outcome. Criterion validity: genetics. Aspects of culture. Reducing stigma. Revision of the classifications: prospects for schizophrenia. One classification or many? Critical issues in the revision process. Disease or a broad syndrome? 'Deconstructing' schizophrenia: categories or dimensions? Endophenotypes. The concept of utility. Conclusion. References. 2 Pathophysiology of schizophrenia (Peter Falkai, Andrea Schmitt and Tyrone D. Cannon). Introduction. Major findings and related pathophysiological hypotheses. Symptom domains and neurotransmitter hypotheses. From domains to disturbed neuronal networks. From networks to the cellular level. Hypothesis of disturbed synaptogenesis and neurogenesis. Effects of antipsychotics. Summary and conclusions. References. 3 Neurocognition, social cognition and functional outcome in schizophrenia (William P. Horan, Philippe-Olivier Harvey, Robert S. Kern and Michael F. Green). Introduction. Neurocognition in schizophrenia. Domains, measurement and magnitude of impairment. Neurocognition as a core deficit of schizophrenia. Associations with functional outcome. The NIMH-MATRICS initiative and current research directions. Social cognition. Domains, measurement and magnitude of impairment. Social cognition as a core feature of schizophrenia. Association with functional outcome. Current research directions. Relationships among neurocognition, social cognition and functional outcome. Distinctiveness of neurocognition and social cognition. Social cognition as a mediator. Future directions. References. 4 The genetics of schizophrenia (James T.R. Walters, Michael O'Donovan and Michael J. Owen). Introduction. Genetic epidemiology of schizophrenia. Family, twin and adoption studies of schizophrenia. Genetic epidemiology – informing diagnosis? Molecular genetics of schizophrenia. Linkage. Positional candidate studies. Functional candidate studies. Chromosomal abnormalities. Genome wide association studies. GWAS in schizophrenia. Copy number variation. The future of schizophrenia genetics. Schizophrenia genetics in the clinic? Conclusions. Acknowledgements. References. 5 Early recognition and prevention of schizophrenia (Patrick D. McGorry and Sherilyn Goldstone). The context for early recognition and prevention. The prodromal stage: definition and assessment. Treatment during the prodromal stage. The psychosis risk syndrome: a novel diagnostic entity? Ethical issues. Summary and conclusions. References. 6 Pharmacological treatment (Jonathan E. Sherin and Stephen R. Marder). Introduction. Current state of pharmacological treatment. Phases of schizophrenia. Acute phase treatment. Stabilization phase treatment. Maintenance phase treatment. Treatment resistant patients. Managing first episodes. Newer antipsychotics. Personalising drug treatment in schizophrenia. Cognition and negative symptoms as therapeutic targets. Glutamatergic targets. Dopamine targets. Cholinergic targets. Histamine targets. Summary. References. 7 Cognitive-behavioural interventions (Suzanne Jolley and Philippa Garety). Introduction. The development of cognitive behavioural approaches to schizophrenia-spectrum psychosis. Cognitive behavioural models of psychosis. Biopsychosocial vulnerability. Life events and schematic beliefs. The role of affect. The central role of appraisal. Reasoning biases. Anomalous experiences. The role of behaviour. Insight and illness appraisals. Cognitive behavioural therapy in schizophrenia. Psychotherapy in schizophrenia: more than unspecific learning? Combining psychotherapy and pharmacotherapy. Efficacy of cognitive behavioural therapy for psychosis (CBTp). Future developments. Conclusions. Acknowledgements. References. 8 Management, rehabilitation, stigma (Wulf Rossler). Introduction. Managing schizophrenia: integrative approaches. Burden for patients, families and communities. Gender issues. Mortality. Legal problems. Health care settings for schizophrenia patients: which setting is optimal? Psychiatric rehabilitation. The international classification of functioning, disability and health. Target population. Conceptual framework. Current approaches. Individual-centred rehabilitation. Cognitive behavioural therapy. Social skills training. Ecological approach to rehabilitation. Housing. Work. Participation in community life with full rights. The contribution of mental health professionals to stigma and discrimination. The role of the psychiatrist in the management and rehabilitation of schizophrenia patients. Outlook. References. Index.

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Book SynopsisBipolar Disorder Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant comorbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is both relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have Trade Review"...The textbook is also an ideal starting point for trainees and young investigators just beginning to explore these subjects. Biopolar Disorder: Clinical and Neurobiological Foundations, then, is a useful addition to the library of most clinicians and academic psychiatrists" (Journal of Clinical Psychiatry, 2011) "The book is a valuable guide to every psychiatrist. It contains a rich and wide range of information about bipolar disorder, step by step from criteria and definitions through biological changes to medical and psychotherapeutic treatment. The reader gets an overview over the newest findings which are presented in a very accessible way. It is definitely a book necessary for each modern psychiatrist!" (Acta Psychiatrica Scandinavica, 2011) "Contributors to 38 chapters offer international perspectives on the disorder's clinical and neurobiological foundations as defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases." (SciTech Book News, December 2010) Table of ContentsPreface. List of Contributors. 1 From Mania to Bipolar Disorder (David Healy). 2 Clinical Features and Subtypes of Bipolar Disorder (Fred K. Goodwin and D.Z. Lieberman). 3 The Long-Term Course and Clinical Management of Bipolar I and Bipolar II Disorders (Lewis L. Judd and Pamela J. Schettler). 4 Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders (Mark A. Frye and Giulio Perugi). 5 DSM-V Perspectives on Classification of Bipolar Disorder (Jan Fawcett). 6 Update on the Epidemiology of Bipolar Disorder (Kathleen R. Merikangas and Tracy L. Peters). 7 Suicide and Bipolar Disorder (Zoltan Rihmer and Jan Fawcett). 8 Neurocognition in Bipolar Disorder (Ivan J. Torres and Gin S. Malhi). 9 The Genius-Insanity Debate: Focus on Bipolarity, Temperament, Creativity and Leadership (Hagop S. Akiskal and Kareen K. Akiskal). 10 Economics of Bipolar Disorder (R. Sabes-Figuera, D. Razzouk and Paul E. McCrone). 11 An Introduction to the Neurobiology of Bipolar Illness Onset, Recurrence and Progression (Robert M. Post and Marcia Kauer-Sant.Anna). 12 Genetics of Bipolar Disorder (Falk W. Lohoff and Wade H. Berrettini). 13 Structural Brain Imaging in Bipolar Disorder (Paolo Brambilla and Jair C. Soares). 14 Functional Magnetic Resonance Imaging, Diffusion Tensor Imaging, and Magnetic Resonance Spectroscopy in Bipolar Disorder (In Kyoon Lyoo and Perry F. Renshaw). 15 Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow (John O. Brooks III, Po W. Wang and Terence A. Ketter). 16 Neurotransmitter Systems in Bipolar Disorder (Marina Nakic, John H. Krystal and Zubin Bhagwagar). 17 Molecular Biology of Bipolar Disorder (Ana Andreazza, Jun Feng Wang and Trevor Young). 18 Mitochondrial Dysfunction and Oxidative Stress (Tadafumi Kato, Flavio Kapczinski and Michael Berk). 19 Neuroendocrinology of Bipolar Illness (Timothy Dinan and Michael Bauer). 20 Circadian Rhythms and Sleep in Bipolar Disorder (Greg Murray and Allison Harvey). 21 Treatment Adherence in Bipolar Disorder (Jan Scott and Mary Jane Tacchi). 22 Acute Mania (Paul E. Keck, Jr, Susan L. McElroy and John M. Hawkins). 23 Pharmacological Treatment of Bipolar Depression (Allan H. Young and Charles B. Nemeroff). 24 Practical Pharmacological Maintenance Treatment of Bipolar Disorder (Alan C. Swann). 25 Rapid Cycling Bipolar Disorder: Phenomenology and Treatment (Joseph F. Goldberg and Michael Berk). 26 Management of Bipolar II Disorder (Gordon Parker and Terence A. Ketter). 27 Management of Comorbidity in Bipolar Disorder (Ihsan M. Salloum, Luca Pani and Tiffany Cooke). 28 Bipolar Disorder and Safety Monitoring for Clinicians: A Review of the Evidence and the Implications (Chris J. Bushe and Mauricio Tohen). 29 Somatic Treatments for Bipolar Disorder: ECT, VNS and TMS (Mark S. George). 30 Novel Therapeutic Strategies for Bipolar Disorder (Rodrigo Machado-Vieira, Husseini K. Manji and Carlos A. Zarate Jr). 31 Psychoeducation as a Core Element of Psychological Approaches for Bipolar Disorders (Francesc Colom and Lesley Berk). 32 Cognitive-Behavioural Therapy for Bipolar Disorder (Sagar V. Parikh and Jan Scott). 33 Interpersonal and Social Rhythm Therapy for Bipolar Disorder (Holly A. Swartz, Ellen Frank, Laura E. Zajac and David J. Kupfer). 34 Family Therapy Approaches to Bipolar Disorder (David J. Miklowitz). 35 Collaborative Care for Bipolar Disorder (Amy M. Kilbourne, David E. Goodrich and Mark S. Bauer). 36 Bipolar Disorder in Women (Benicio N. Frey, Karine A. Macritchie, Claudio N. Soares and Meir Steiner). 37 Phenomenology and Treatment of Bipolar I Disorder in Children: A Critical Review (Gabrielle A. Carlson and Elizabeth B. Weller). 38 Bipolar Disorder in the Elderly (Martha Sajatovic and Lars Vedel Kessing). Index.

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Book SynopsisThis book provides the contemporary, caring guidance you need to diagnose and manage seizures in a young patient. Beginning with an overview of the classification of seizure syndromes, the authors take a practical approach to a common but complex clinical challenge.Trade Review“In general, I think this book very sound. It would be an excellent introduction for neurology residents and a good review for general paediatric neurologists who feel a bit out of touch with current treatments for epilepsy.” (The Canadian Journal of Neurological Sciences, 1 September 2013) “This is an exceptional read, unlike others in the way it addresses the treatment of children with epilepsy, rather than just the treatment of epilepsy.” (Doody’s, 2 August 2013)Table of Contentsp>List of contributors xiii Preface xvii Section 1 Epidemiology and classification of childhood epilepsies 1 Section editor: Phillip L. Pearl 1 Epidemiology and common comorbidities of epilepsy in childhood 3 Jay Salpekar, Matthew Byrne, and Georgann Ferrone 1.1 Epidemiology 3 1.2 Incidence and prevalence 4 1.3 Gender and age 4 1.4 Classification 5 1.5 Febrile seizures 6 1.6 Etiology 6 1.7 Psychiatric comorbidity 7 1.8 Psychological and psychosocial stress related to chronic disease 7 1.9 Psychiatric symptoms related to medication side effects 8 1.10 Psychiatric comorbidity related to epilepsy pathophysiology 8 1.11 Attention-deficit/hyperactivity disorder (ADHD) 9 1.12 Anxiety 10 1.13 Depression 11 1.14 Intellectual and developmental disabilities (IDD) 12 1.15 Conclusion 12 References 13 2 Classification and definition of seizures and epilepsy syndromes in childhood 17 Susan E. Combs and Phillip L. Pearl 2.1 Introduction 17 2.2 Purpose and goals of definitions and classification 17 2.3 Systems of classification and definitions 18 2.4 Seizures 18 2.5 Generalized seizures 19 2.6 Focal seizures 22 2.7 Syndromes 23 2.8 Specific age-related epilepsy syndromes 25 2.9 Future directions 34 Acknowledgements 34 References 34 3 Initiating and withdrawing medical management 37 David T. Hsieh and Bhagwan Indur Moorjani 3.1 Initiating medical management 37 3.2 The chances of seizure recurrence after the first unprovoked seizure 39 3.3 Seizure recurrence 42 3.4 The possible adverse effects of seizure recurrence 42 3.5 The risks of initiating antiepileptic drug therapy 44 3.6 The benefits of initiating antiepileptic drug therapy 45 3.7 How to initiate treatment with antiepileptic drugs 45 3.8 Special circumstances 48 3.9 Summary: initiating medical management 48 3.10 Withdrawing medical management 49 3.11 The long-term prognosis of childhood-onset epilepsy 50 3.12 When to consider discontinuing antiepileptic drug therapy 51 3.13 Risk factors for seizure recurrence after discontinuation 51 3.14 The risks of discontinuing antiepileptic drug therapy 54 3.15 The benefits of discontinuing antiepileptic drug therapy 55 3.16 How to discontinue antiepileptic drugs 55 3.17 Special circumstances 55 3.18 Summary: withdrawing medical management 56 3.19 Disclaimer 57 References 57 4 Common genetic and neurocutaneous disorders in childhood epilepsy 59 Dewi Frances T. Depositario-Cabacar, William McClintock, and Tom Reehal 4.1 Idiopathic epilepsies 60 4.2 Symptomatic epilepsies 63 4.3 Epilepsy in common chromosomal abnormalities 63 4.4 Epilepsy in metabolic and mitochondrial disorders 65 4.5 Epilepsy in malformations of cortical development 66 4.6 Neurocutaneous disorders 67 4.7 Summary 70 References 70 Section 2 Diagnostic evaluation of childhood epilepsies 73 Section editor: David F. Clarke 5 Evaluating the child with seizures 75 Kristen Park and Susan Koh 5.1 Emergent diagnosis and management 76 5.2 Subsequent evaluation 79 5.3 Additional neurodiagnostic evaluation 84 References 87 6 The use of EEG in the diagnosis of childhood epilepsy 90 David F. Clarke 6.1 Technical aspects of the EEG 91 6.2 Methods used to increase EEG yield 91 6.3 When should an EEG be ordered? 92 6.4 EEG findings in epilepsy and epilepsy syndromes 93 6.5 Neonatal EEGs 94 6.6 The EEG in focal epilepsy 96 6.7 The EEG of generalized epilepsy 99 6.8 Specific disease-related epilepsy syndromes 104 6.9 Conclusion 105 References 105 7 Imaging of pediatric epilepsy 107 Asim F. Choudhri 7.1 Introduction 107 7.2 Imaging considerations 107 7.3 Congenital malformations 117 7.4 Neoplasms 124 7.5 Acquired/idiopathic abnormalities 126 References 127 8 Non-epileptic paroxysmal events of childhood 129 Sucheta M. Joshi 8.1 Introduction 129 8.2 Breath-holding spells 130 8.3 Parasomnias 131 8.4 Benign paroxysmal positional vertigo of childhood 133 8.5 Syncope 134 8.6 Paroxymal non-epileptic events (PNEs) with a psychiatric or behavioral basis 134 8.7 Hyperekplexia 136 8.8 Alternating hemiplegia of childhood 136 8.9 Movement disorders 137 8.10 Sandifer syndrome 138 8.11 Conclusion 138 References 139 Section 3 Principles of treatment 143 Section editor: James W. Wheless 9 Pharmacology of antiepileptic drugs 145 James W. Wheless 9.1 Pharmacokinetics 146 9.2 Pharmacogenomics 155 References 157 10 Therapeutic efficacy of antiepileptic drugs 159 James W. Wheless 10.1 Efficacy-based treatment guidelines 160 10.2 Antiepileptic drug selection based on specific pediatric epilepsy syndromes 164 10.3 Influence of comorbidities in children with epilepsy 171 10.4 Conclusions 172 References 172 11 Adverse effects of antiepileptic drugs 175 James W. Wheless 11.1 Introduction 175 11.2 Specific drugs 179 11.3 At-risk profiles and monitoring 189 References 191 12 Vagus nerve stimulation therapy and epilepsy surgery 193 Kate Van Poppel and James W. Wheless 12.1 Vagus nerve stimulation 195 12.2 Epilepsy surgery 203 12.3 Conclusions 215 References 215 13 Dietary therapies to treat epilepsy 219 James W. Wheless 13.1 History 220 13.2 Efficacy 221 13.3 Mechanism of action 228 13.4 Selection of candidates for the diet 232 13.5 Initiation and maintenance 234 13.6 Complications 236 13.7 The ketogenic diet in the twenty-first century 239 References 239 Resources 240 Websites 241 Section 4 Generalized seizures and generalized epilepsy syndromes 243 Section editor: Amy L. McGregor 14 Idiopathic generalized epilepsies 245 Amy L. McGregor 14.1 Clinical features 246 14.2 Natural history 248 14.3 Genetics 248 14.4 Treatment 248 14.5 Classification 249 14.6 Myoclonic epilepsy in infancy 249 14.7 Childhood absence epilepsy (CAE) 250 14.8 Juvenile absence epilepsy (JAE) 252 14.9 Juvenile myoclonic epilepsy (JME) 254 14.10 Epilepsy with generalized tonic-clonic seizures alone (IGE-GTCs) 256 14.11 Epilepsy with myoclonic absence 257 14.12 Epilepsy with myoclonic-atonic seizures/Doose syndrome 258 14.13 Febrile seizures plus (FS+) 259 14.14 Eyelid myoclonia with absences (EMA)/Jeavons syndrome 260 14.15 Summary 262 References 264 15 Cryptogenic and symptomatic generalized epilepsies: epilepsies with encephalopathy 267 Karen Keough 15.1 Neonatal-onset epilepsies with encephalopathy 268 15.2 Infantile-onset epilepsies with encephalopathy 270 15.3 Epilepsies with encephalopathy with onset later in infancy 275 15.4 Epilepsies with encephalopathy with onset after infancy 277 15.5 Continuous spike wave of sleep (CSWS) and Landau–Kleffner syndrome (LKS) 279 References 280 Section 5 Partial-onset seizures and localization-related epilepsy syndromes 283 Section editor: James W. Wheless 16 Idiopathic partial epilepsies 285 Freedom F. Perkins Jr 16.1 Benign infantile seizures 286 16.2 Benign childhood epilepsy with centrotemporal spikes 287 16.3 Childhood occipital epilepsy (Panayiotopoulos type) 289 16.4 Late-onset childhood occipital epilepsy (Gastaut type) 292 References 294 17 Cryptogenic and symptomatic partial epilepsies 296 Stephen Fulton 17.1 Etiology 296 17.2 Seizure phenomena 297 17.3 Temporal lobe epilepsy 297 17.4 Extratemporal epilepsy 303 17.5 Occipital lobe epilepsy 306 17.6 Parietal lobe epilepsy 307 17.7 Hypothalamic hamartoma 307 17.8 Other localizing and lateralizing signs 308 References 309 Section 6 Epilepsies relative to age, etiology, or duration 311 Section editor: Yu-Tze Ng 18 Neonatal seizures 313 Eric V. Hastriter 18.1 Significance of neonatal seizures 313 18.2 Pathophysiology of neonatal seizures 314 18.3 Classification and clinical features of neonatal seizures 316 18.4 Electrographic seizures 317 18.5 Monitoring and recording 317 18.6 Etiology of neonatal seizures 321 18.7 Metabolic causes for neonatal seizures 323 18.8 Inborn errors of metabolism 323 18.9 Treatment 327 18.10 Chronic postnatal epilepsy and the need for long-term treatment 328 18.11 Potential adverse effects of antiepileptic drugs on the immature CNS 329 18.12 Conclusion 329 References 330 19 Febrile seizures 333 Marie Francisca Grill 19.1 Introduction 333 19.2 Definition 333 19.3 Incidence and prevalence 334 19.4 Pathophysiology 334 19.5 Prognosis 334 19.6 Initial evaluation and management 335 19.7 Long-term management 338 19.8 Management in practice 341 19.9 Genetics 342 19.10 Parent counseling 343 19.11 Conclusion 344 References 344 20 Status epilepticus in childhood 346 Yu-Tze Ng and Rama Maganti 20.1 Definition 346 20.2 Epidemiology 349 20.3 Pathophysiology 349 20.4 Etiology 350 20.5 Diagnosis and investigations 351 20.6 EEG patterns in status epilepticus 352 20.7 Treatment 356 20.8 Prognosis 359 References 359 Index 365

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Book SynopsisThe focus of this book is on speech production and speech processing associated with cleft palate, covering phonetic (perceptual and instrumental), phonological and psycholinguistic perspectives, and including coverage of implications for literacy and education, as well as cross-linguistic differences. It draws together a group of international experts in the fields of cleft lip and palate and speech science to provide an up-to-date and in-depth account of the nature of speech production, and the processes and current evidence base of assessment and intervention for speech associated with cleft palate. The consequences of speech disorders associated with cleft on intelligibility and communicative participation are also covered. This book will provide a solid theoretical foundation and a valuable clinical resource for students of speech-language pathology, for practising speech-language pathologists, and for others interested in speech production in cleft palate, including researchers aTable of ContentsList of Contributors xi Preface xvii Part One Speech Production and Development 1 Sara Howard and Anette Lohmander 1 Physical Structure and Function and Speech Production Associated with Cleft Palate 5 Martin Atkinson and Sara Howard 1.1 Introduction 5 1.2 The Hard and Soft Palates and the Velopharynx 6 1.3 The Tonsils and Adenoids 9 1.4 The Larynx 11 1.5 The Jaws, Dentition and Occlusion 12 1.6 Symmetry: Structure and Function 15 1.7 The Tongue 16 1.8 The Lips 18 1.9 Summary: Compensations Across Systems 19 References 19 2 The Development of Speech in Children with Cleft Palate 23 Kathy L. Chapman and Elisabeth Willadsen 2.1 Overview 23 2.2 The Impact of Clefting on Speech Production 24 2.3 Variables Impacting Speech Development for Young Children with Cleft Palate 25 2.4 Speech Development: Birth to Age Five 26 2.5 Conclusion 35 References 36 3 The Influence of Related Conditions on Speech and Communication 41 Christina Persson and Lotta Sjögreen 3.1 Introduction 41 3.2 Conditions Related to Structural Etiologies 42 3.3 Conditions Related to Neurological Aetiology 47 3.4 Conditions Related to a Combination of Structural and Neurological Aetiology 49 3.5 Clinical Implications 50 References 50 4 Surgical Intervention and Speech Outcomes in Cleft Lip and Palate 55 Anette Lohmander 4.1 Introduction 55 4.2 Basics of Surgery on Cleft Palate 57 4.3 Basics of Outcomes 64 4.4 Speech Outcomes 65 4.5 Conclusion 69 Appendix 4.A Review of Evidence and Methodology in Studies of Speech Outcome in Individuals Born with Cleft Lip and Palate 70 References 82 5 Secondary Management and Speech Outcome 87 John E. Riski 5.1 Introduction 87 5.2 Secondary Surgical Management of Velopharyngeal Incompetence 88 5.3 Secondary Pharyngeal Flap 88 5.4 Posterior Pharyngeal Wall Augmentation by Muscle Transposition 91 5.5 Studies Comparing Treatments of VPI 94 5.6 Posterior Pharyngeal Wall Augmentation by Implants and Injections 95 5.7 Velarplasty 96 5.8 Other Considerations in Managing VPI 97 5.9 Complications Secondary to Pharyngoplasties 99 5.10 Conclusions 99 References 100 6 Cleft Palate Speech in the Majority World: Models of Intervention and Speech Outcomes in Diverse Cultural and Language Contexts 105 Debbie Sell, Roopa Nagarajan and Mary Wickenden 6.1 Introduction 105 6.2 Speech Outcomes in a Majority World Context 106 6.3 Different Models of Provision 109 6.4 Attitudes/Cultural Aspects 115 6.5 Conclusion 119 References 119 Part Two Speech Assessment and Intervention 123 Anette Lohmander and Sara Howard 7 Phonetic Transcription for Speech Related to Cleft Palate 127 Sara Howard 7.1 Introduction 127 7.2 What is Phonetic Transcription? 128 7.3 Why Transcribe? 129 7.4 What to Transcribe and How to Transcribe It 130 7.5 Features of Cleft Speech Production 131 7.6 Pitfalls of Transcription 134 7.7 Conclusion 138 Appendices 139 References 142 8 Instrumentation in the Analysis of the Structure and Function of the Velopharyngeal Mechanism 145 Debbie Sell and Valerie Pereira 8.1 Introduction 145 8.2 Visualization of the Velopharyngeal Mechanism 147 8.3 Multiview Videofluoroscopy 147 8.4 Nasendoscopy Procedure 151 8.5 Magnetic Resonance Imaging (MRI) 155 8.6 Variability in Practice 158 8.7 Future 162 References 162 9 Cross Linguistic Perspectives on Speech Assessment in Cleft Palate 167 Gunilla Henningsson and Elisabeth Willadsen 9.1 Introduction 167 9.2 Vulnerable Speech Sounds 168 9.3 Language Background of the Listener Assessing the Speech of Children with Cleft Palate 170 9.4 What Is Known about More Unfamiliar Languages? 173 9.5 Cross Linguistic Speech Samples 173 9.6 Influence on Assessment of Language Acquisition in the Young Child with Cleft Palate 176 9.7 Conclusion 177 References 177 10 Voice Assessment and Intervention 181 Lesley Cavalli 10.1 Introduction 181 10.2 Defining a Voice Disorder 181 10.3 Assessment 184 10.4 Instrumental Assessment 189 10.5 Vocal Handicap Measures 190 10.6 Treatment 191 10.7 Conclusion 195 References 196 11 Nasality – Assessment and Intervention 199 Triona Sweeney 11.1 Introduction 199 11.2 Perceptual Assessment of Nasality and Nasal Airflow Errors 205 11.3 Instrumental Assessment of Nasality and Nasal Airflow Errors 207 11.4 Interpreting Results 211 11.5 Intervention 214 11.6 Conclusion 216 Appendix 11.A Temple Street Scale of Nasality and Nasal Airflow Errors 217 References 217 12 Articulation – Instruments for Research and Clinical Practice 221 Fiona E. Gibbon and Alice Lee 12.1 Introduction 221 12.2 Electropalatography (EPG) 222 12.3 Imaging Techniques 228 12.4 Motion Tracking 233 12.5 Conclusion 235 Acknowledgement 235 References 235 13 Psycholinguistic Assessment and Intervention 239 Joy Stackhouse 13.1 Introduction 239 13.2 What is a Psycholinguistic Approach? 240 13.3 A Psycholinguistic Assessment Framework 242 13.4 Intervention from a Psycholinguistic Perspective 245 13.5 Literacy: Phonological Awareness and Spelling 250 13.6 Summary 254 References 255 14 Early Communication Assessment and Intervention 259 Nancy Scherer and Brenda Louw 14.1 Introduction 259 14.2 Assessment 260 14.3 Intervention 267 References 272 15 Phonological Approaches to Speech Difficulties Associated with Cleft Palate 275 Anne Harding-Bell and Sara Howard 15.1 Introduction 275 15.2 Variability, Variation and Compensation 277 15.3 Classification of Speech Difficulties Related to Cleft Palate 278 15.4 Phonological Assessment of Speech Data Related to Cleft Palate 278 15.5 Phonological Consequences of Speech Production Related to Cleft Palate 279 15.6 Intervention 283 15.7 Summary 287 References 288 16 Speech Intelligibility 293 Tara L. Whitehill, Carrie L. Gotzke and Megan Hodge 16.1 Introduction 293 16.2 Definition of Intelligibility and Related Concepts 294 16.3 Measurement Issues 294 16.4 Studies of Intelligibility in Speakers with Cleft Palate 296 16.5 Current and Future Developments 298 16.6 Conclusion 300 References 301 17 Communicative Participation 305 Christina Havstam and Anette Lohmander 17.1 Introduction 305 17.2 ICF 306 17.3 Communicative Participation 307 17.4 Conclusions and Clinical Implications 312 References 312 18 Evaluation and Evidence-Based Practice 317 Linda D. Vallino-Napoli 18.1 Introduction 317 18.2 Intervention for Speech Disorders 318 18.3 Evidence-Based Practice 319 18.4 The Systematic Review Process 323 18.5 Evidence Findings Establishing Therapy Effectiveness 325 18.6 Instrumentation – Visual Feedback 349 18.7 Surgery 350 18.8 Comments about Intervention Effectiveness 351 18.9 Intervention and the International Classification of Function (ICF) 352 18.10 Research Designs for Intervention Studies 352 18.11 Conclusions 352 Appendix 18.A Commonly Used Evidence Hierarchies for Intervention Studies 354 References 354 Index 359

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Book SynopsisTwo key challenges face mental health practitioners: making the correct psychiatric diagnosis and choosing the most appropriate treatment option. This book aims to help with both. Clinical Guide to the Diagnosis and Treatment of Mental Disorders - Second Edition combines clinically-relevant information about each of theDSM-IV-TR diagnoses with clear, detailed information on treatment options, giving full clinical management advice. Once again, the editors, both leading psychiatrists, have condensed the chapters on Disorders from Tasman et al's acclaimed two volume textbook of Psychiatry (now in its Third Edition), retaining only the content they deem particularly relevant to the clinician for ease of use. Each disorder is discussed under the headings of Diagnosis (including Assessment Issues, Comorbidity, Course, and Differential Diagnosis, giving diagnostic decision trees where relevant) and Treatment (listing all therapeutic options, giving practical advice fTrade Review"In my opinion, this book would be worth borrowing from the library in order to read specific chapters of interest; perhaps, the common mental health conditions or a rarity recently encountered in clinic." (Occupational Medicine, 8 March 2011) "The main addition to this edition is a useful introductory chapter on the psychiatric interview, with comments on "compiling the psychiatric database" (which seems to be what used to be called the patient's notes). I was also glad to see rather more mentions of evidence-supported psychological therapies in among the recommended drug treatments than in the previous edition." (Journal of Mental Health, August 2010)Table of ContentsPreface xxvii Chapter 1 The Psychiatric Interview 1 Chapter 2 Childhood Disorders: Intellectual Disability 17 Chapter 3 Childhood Disorders: Learning and Motor Skills Disorders 31 Chapter 4 Childhood Disorders: Communication Disorders 41 Chapter 5 Childhood Disorders: The Pervasive Developmental Disorders 49 Chapter 6 Childhood Disorders: Attention-Deficit and Disruptive Behavior Disorders 61 Chapter 7 Childhood Disorders: Feeding and Related Disorders of Infancy or Early Childhood 73 Chapter 8 Childhood Disorders: Tic Disorders 81 Chapter 9 Childhood Disorders: Elimination Disorders and Childhood Anxiety Disorders 87 Chapter 10 Stereotypic Movement Disorder and Reactive Attachment Disorder 99 Chapter 11 Delirium, Dementia, and Other Cognitive Disorders 105 Chapter 12 Mental Disorders Due to a General Medical Condition 131 Chapter 13 General Approaches to Substance and Polydrug Use Disorders 145 Chapter 14 Substance-Related Disorders: Alcohol 153 Chapter 15 Substance-Related Disorders: Amphetamine 167 Chapter 16 Substance-Related Disorders: Caffeine 173 Chapter 17 Substance-Related Disorders: Cannabis 181 Chapter 18 Substance-Related Disorders: Cocaine 185 Chapter 19 Substance-Related Disorders: Hallucinogens and MDMA 195 Chapter 20 Substance-Related Disorders: Inhalants 203 Chapter 21 Substance-Related Disorders: Nicotine 211Treatment 214 Chapter 22 Substance-Related Disorders: Opioids 221 Chapter 23 Substance-Related Disorders: Phencyclidine 231 Chapter 24 Substance-Related Disorders: Sedatives, Hypnotics, and Anxiolytics 235 Chapter 25 Schizophrenia and Other Psychoses 245 Chapter 26 Mood Disorders: Depressive Disorders 279 Chapter 27 Mood Disorders: Premenstrual Dysphoric Disorder 303 Chapter 28 Mood Disorders: Bipolar Disorder 309 Chapter 29 Anxiety Disorders: Panic Disorder With and Without Agoraphobia 323 Chapter 30 Anxiety Disorders: Social and Specific Phobias 331 Chapter 31 Anxiety Disorders: Obsessive–Compulsive Disorder 347 Chapter 32 Anxiety Disorders: Traumatic Stress Disorders 359 Chapter 33 Anxiety Disorders: Generalized Anxiety Disorder 373 Chapter 34 Somatoform Disorders 383 Chapter 35 Factitious Disorders 409 Chapter 36 Dissociative Disorders 417 Chapter 38 Eating Disorders 443 Chapter 39 Sleep and Sleep–Wake Disorders 453 Chapter 40 Impulse Control Disorders 475 Chapter 41 Adjustment Disorders 489 Chapter 42 Personality Disorders 493 Index 511

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Book SynopsisMental health concerns are the most serious and prevalent healthproblems among students in higher education. Increasingly effectivepsychopharmacological and psychotherapeutic treatments havefacilitated matriculation for students with histories of anxiety,mood, personality, eating and substance abuse disorders.Trade Review"Mental Health Care in the College Community is a beautifully organized resource that is encyclopedic in its scope and detail. It offers administrators the why and how-to of creating state-of-the-art services that include crisis intervention, triage, psychotherapy, medication consultation, testing, referral, outreach, working with parents, and training psychiatry residents and psychology and social work interns. The authors are attuned to the specific needs of the college environment, among the most pressing of which is timeliness." (Psychiatric Services, American Psychiatric Association, August 2011) "What makes the volume cohesive is the prominence given to the application of the community mental health and public health models to mental health promotion and care on college campuses." (Journal of the American Academy of Child and Adolescent Psychiatry, March 2012) "Kay and Schwartz’s text breaks new ground in the attempt to assemble a comprehensive, yet compact resource for college mental health clinicians and health services administrators. I expect that we will hear further from this cohort of clinical innovators" (Journal of Clinical Psychiatry, December 2011) "This book should be on the shelf of every clinician and administrator working in or with a college or university health clinic. Clinicians and trainees in departments of psychiatry, social work, psychology, and nursing would be well advised to read this book from cover to cover" (Michelle Riba, Psychiatry: Interpersonal Biological Processes October 2011) "I would encourage any individual working at the college or university level that comes into contact with students to read Mental Health Care in the College Community" (Synergy, NASPA Newsletter, February 2011) "I read this text with the same mantra running through my mind: “This book IS good for me, despite my reaction to its psychiatric lens.” Indeed, this book is very, very good. There is a tremendous amount of information culled from a variety of sources (bear in mind that articles in this field are published in many different journals), and this information is seasoned well with the authors' clinical and administrative experiences ... offers a smorgasbord of pertinent, informed, and thoughtful chapters on working in the college setting." (Journal of College Student Psychotherapy, 2011) "Mental Health Care in the College Community provides an enormous amount of valuable information on a number of diverse topics pertaining to the campus setting. Working with parents, different model of care, suicide prevention, training programs, and working with special populations are just a few..." (American Journal of Psychiatry, 2011) "This thorough review and discussion of intervention studies could be helpful to student affairs departments (e.g., residential living, judicial affairs) in making decisions about which approach best fits their campus." (PsycCRITIQUES, November 2010) "... Mental Health Care in the College Community is an excellent overview of the key aspects of college mental health services provision. It will be of great help to administrators as they evaluate their existing mental health services or plan for their improvement and expansion." (MIWatch.org, 2010) "I would like to thank you and Dr. Schwartz for your excellent work on your book Mental Health Care in the College Community. I am a psychologist who has held leadership roles in community mental health centers and hospitals for 20 years.... Finding your book was a godsend in quickly bringing me up to speed on the issues.... I look forward to joining the ranks of college counseling directors and furthering the development of this important field." (Gary Dunn, 2011) "Mental Health Care in the College Community will be of interest to counselling centre clinicians and also to postgraduate students as they work to understand how students' mental health impacts the university community" (Early Interventions in Psychiatry, 2011) "For readers unfamiliar with mental health care at higher education institutions, the book is an effective guide to better understanding how counselling services are provided in these settings. The book may also serve as a textbook in graduate counseling and higher education courses that examine the delivery of counselling services at various colleges and universities" (Community College Review, November 2011)Table of ContentsPreface. List of Contributors. 1 The Rising Prominence of College and University Mental Health Issues (Jerald Kay). 1.1 Introduction. 1.2 How prevalent are emotional disturbances and mental disorders? 1.3 Study limitations. 1.4 A developmental approach to college mental health. 1.5 Ethical and legal issues. 1.6 Conclusion. 2 History of College Counseling and Mental Health Services and Role of the Community Mental Health Model (Paul Barreira and Malorie Snider). 2.1 Introduction. 2.2 Early development of college and university counseling centers and mental hygiene programs: pre-1945. 2.3 Professionalism and response to increase in student enrolment. 2.4 Formalization of roles and attention to developmental issues and prevention. 2.5 Community Mental Health Movement. 2.6 An example of the early application of community mental health at colleges and universities: Dana Farnsworth. 2.7 Potential modern applications of the CHMmodel to educational settings. 2.8 Conclusion. References. 3 The Reporting Structure and Relationship of Mental Health Services with Health Services (Gregory T. Eells and Victor Schwartz). 3.1 Introduction. 3.2 Review of literature. 3.3 Administrative integration issues. 3.4 Clinical issues. 3.5 Recommendations. 3.6 Conclusion. 4 Components of an Effective College Mental Health Service (Gregory T. Eells and Robert A. Rando). 4.1 Introduction. 4.2 Leadership philosophy and staff morale. 4.3 Administrative issues. 4.4 Clinical services. 4.5 Working with outside community mental health resources. 4.6 Conclusion. Appendix A: Triage form (Adapted from Cornell University). 5 Essential Services in College Counseling (Richard J. Eichler and Victor Schwartz). 5.1 Introduction. 5.2 Access to care. 5.3 Clinical consultation, treatment planning and referral. 5.4 Personal counseling and brief psychotherapy. 5.5 Medication services. 5.6 Referring students for consultation. 5.7 Group therapy in college mental health services. 5.7.1 Types of groups. 5.8 Psychological testing and assessment. 5.9 Community outreach. 5.10 Concluding remarks. Appendix A: The relationship between predictive validity and base rate. 6 The Counseling Center Team (Paul Grayson). 6.1 Introduction. 6.2 The team. 6.3 Challenges to morale and teamwork. 6.4 The director’s responses. 7 Legal and Ethical Issues in College Mental Health (Karen Bower and Victor Schwartz). 7.1 Introduction. 7.2 Conceptual framework. 7.3 Legal framework. 7.4 Application. 7.5 Conclusion. 8 Working with the Campus Community (Lorraine D. Siggins). 8.1 Introduction. 8.2 Some developmental considerations. 8.3 The evolution of the college mental health service mission. 8.4 The college mental health service and the university community. 8.5 Outreach educational and consultative services to students. 8.6 Relationship of college mental health service to the faculty, university administration and deans of student life. 8.7 Confidentiality. 8.8 Conclusion. 8.9 Appendix A: A model “at risk/student support program” in a small residential campus. 9 Crisis and Crisis Intervention on College Campuses (Morton M. Silverman and Rachel Lipson Glick). 9.1 What is a crisis? 9.2 Crisis intervention. 9.3 Common crises and suggested responses. 9.4 When does a crisis become a psychiatric emergency? 9.5 Disasters and other crises that affect multiple students. 9.6 Working with campus leadership to prevent crisis and improve mental health. 9.7 Conclusion. 10 Working with Parents and Families of Young Adults (Kristine A. Girard). 10.1 Introduction. 10.2 Young adult development. 10.3 Generational effects. 10.4 The baby boomers. 10.5 Generation X. 10.6 The millennial generation. 10.7 Privacy standards in higher education. 10.8 Influence of case law on privacy. 10.9 Privacy meets generational attitudes. 10.10 Privacy in the transition from secondary schools to higher education. 10.11 The risk management team. 10.12 Health insurance. 10.13 Family therapy in the university health service. 10.14 Required medical withdrawal. 10.15 Behavioral problems in the residential community. 10.16 Mental health prevention. 10.17 Crisis management. 10.18 Conclusion. 11 Psychiatry Residency Training in College Mental Health Services (Jerald Kay and Victor Schwartz). 11.1 Introduction. 11.2 Benefits to services. 11.3 Benefits to trainees. 11.4 Benefits to training programs. 11.5 Characteristics of a rotation. 11.6 Centrality of supervision. 11.7 Didactic curriculum. 11.8 Developmental psychopathology. 11.9 Psychopharmacology. 11.10 The resident's clinical theoretical framework. 11.11 Increasing visibility of social media. 11.12 Fellowships in CMH. 11.13 Conclusion. Appendix A: Helpful hints for supervisors. Appendix B: PGY IV (Post Graduate Year Four) psychiatric resident rotation, student mental health rotations, Wright State University, University of Dayton. 12 Psychology and Social Work Training in University Mental Health (David A. Davar). 12.1 Introduction. 12.2 Administrative matters. 12.3 Ethical and legal considerations. 12.4 Recruitment and selection of trainees. 12.5 Running a successful training program. 12.6 From theory to college counseling practice: CAPS orientation for new trainees. 12.7 From theory to college counseling practice. 12.8 Experiential learning: trainee epistemology. 12.9 Organization of training. 12.10 Teaching the intake interview in the college setting. 12.11 Nurturing competency, addressing deficiency. 12.12 Recognizing and addressing deficiencies. 12.13 Social work and psychology therapists-in-training. 12.14 Conclusion. Appendix A: Sample syllabus for counseling center trainees. 13 Special Populations (Beverly J. Fauman and Marta J. Hopkinson). 13.1 Introduction. 13.2 Athletes. 13.3 International students. 13.4 Returning students. 13.5 Students with chronic illnesses. 13.6 Graduate students. 13.7 Transfer students. 13.8 Lesbian, gay, bisexual, transgendered and questioning students. 13.9 Veterans. 13.10 Victims of sexual assault. 13.11 Conclusion. 14 Using A Public Health Approach to Address Student Mental Health (Laurie Davidson and Joanna H. Locke). 14.1 Introduction. 14.2 A public health approach to campus mental health. 14.3 Building momentum and infrastructure. 14.4 Thinking and planning strategically. 14.5 Strategies for promoting mental health and preventing suicide among college students. 14.6 Conclusion. 15 Magnitude and Prevention of College Alcohol and Drug Misuse: US College Students Aged 18-24 (Ralph W. Hingson and Aaron M. White). 15.1 Introduction. 15.2 Methods: calculating changes in alcohol-related mortality. 15.3 Study results. 15.4 Discussion: estimates of the magnitude of college drinking problems. 15.5 Implications. 15.6 Interventions to reduce college drinking. 15.7 Conclusions. 16 Conducting Research in College and University Counseling Centers (Chris Brownson). 16.1 Introduction. 16.2 Types of research in university and college counseling centers. 16.3 Practical aspects of conducting research in counseling centers. 16.4 Future directions and conclusion. 17 International Perspectives: College Mental Health in the United Kingdom (Mark Phippen). 17.1 Introduction. 17.2 Setting the scene. 17.3 Support systems in UK universities - Student Services. 17.4 Student mental health - a growing issue. 17.5 The experience of international students in the United Kingdom. 17.6 Conclusion - where does this leave university counselling? References. Index.

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Book SynopsisBipolar Psychopharmacotherapy covers both pharmacotherapy and the role of psychotherapy, psychoeducation, and social approaches to provide a broad integrative philosophy of care for bipolar patients.Trade Review“This is an interesting, easy to read, and informative book that presents research treatment outcome data to support treatment direction and choices. Anything one needs to know about bipolar disorder is thoroughly covered. This is a book psychiatrists, psychologists, social workers, nurses, doctors of pharmacy, residents, students in medical training programs, patients, and their families may find helpful in understanding the complexities and available treatment choices and their limitations. With the continuing research, this update is justified, and a third edition will soon be needed to keep current.” (Doddy's, 20 April 2012) Table of ContentsList of Contributors. Preface to the Second Edition. Chapter 1 The scope of bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment: Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1 Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and better prophylactic agents about to oust lithium? 2.6 Combination treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical background. 3.2 Structure–activity relationships. 3.3 Pharmacodynamic properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate in treatment of bipolar disorder in children and adolescents. 3.12 Use in bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid with ADHD. 3.14 Bipolar disorder comorbid with borderline personality disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17 Adverse effects in combination therapy, compared with monotherapy. 3.18 Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological profile and clinical utility of lamotrigine in mood disorders (Marc L.M. van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina). 4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter 6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the clinical trial development of olanzapine. 6.3 Efficacy in the treatment of acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5 Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute tranquillization in mania. 7.3 Sedation is not required for antipsychotics to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania. 7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics. 7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in mania. 7.9 Recent comparative trials without placebo. 7.10 Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9 Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4 Risperidone long-acting injectable (LAI) in the maintenance treatment of bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz, Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology. 10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine. 10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder (Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N. Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance treatment of bipolar disorder. 11.8 Practical guidance on the use of ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10 Treatment of special populations. 11.11 Summary and conclusions. Chapter 12 Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1 Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4 Aripiprazole safety and tolerability. 12.5 Treatment of special populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology. 13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and mixed states. 13.5 Asenapine: Efficacy and tolerability during extension treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1 Introduction. 14.2 Rationale for complex combination therapy in bipolar illness. 14.3 Principles of building an effective therapeutic regimen. 14.4 Conclusions. Chapter 15 The role of antidepressants in bipolar disorder (Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants. 15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine, duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications. Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy, Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2 Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender differences in phenomenology. 16.4 Gender differences in course and outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8 Summary. Chapter 17 Pediatric bipolar disorder: The promise of psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1 Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5 Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I. Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar disorder in old age. 18.2 Management of bipolar disorder in the elderly. 18.3 Treatment of bipolar depression in older adults. 18.4 The future. Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1 What is a mixed state? 19.2 General considerations for treatment strategies in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20 Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F. Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2 Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4 Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion. Chapter 21 Novel therapeutic approaches for treating bipolar disorder (Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov, Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2 The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4 The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final remarks. Chapter 22 The pivotal role of psycho-education in the long-term treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1 Introduction. 22.2 On the need for psycho-education. 22.3 The five ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5 Early warning signs – detection. 22.6 Lifestyle regularity (and miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments. Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment according to phase and severity of illness. 23.2 Pretreatment evaluation and monitoring of pharmacotherapy. 23.3 Drug response and treatment setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar illness. Chapter 24 Pharmacological prevention of suicide in bipolar patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders. 24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K. Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder. 25.3 Principles of caring. 25.4 Special considerations for hypomanic and cyclothymic patients. 25.5 Conclusion. References. Index.

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Book SynopsisAcross all cultures parenting is the foundation of family life. It is the domain where adult mental health meets infant development. Beginning in pregnancy, parenting involves many conscious and unconscious processes which have recently been shown to affect a child's development significantly.Trade Review"..this offers a comprehensive, evidence-based, holistic perspective on a crucial time in infant and adult life which could easily be a key text for any mental health professional working in child and family or adult services." (Journal of Mental Health, 2011) "The authors of the various chapters present a very updated and thorough review of scientific knowledge, in a clear and easily readable manner. The book is indeed suited for adult or child mental health professionals who do not have a specific specialty in working with infants, and vice versa, for infant mental health professionals with less experience in working with older children and adults." (The Signal, 1 May 2011) "The authors of the various chapters present a very updated and thorough review of scientific knowledge, in a clear and easily readable manner. The book is indeed suited for adult or child mental health professionals who do not have a specific specialty in working with infants, and vice versa, for infant mental health professionals with less experience in working with older children and adults. In this manner it stimulates awareness and collaboration between clinicians who treat different family members of the newly born infant. Such a bridge will surely enhance well being and treatment success. It will also promote collaborations between researchers who study different aspects of behavior and development in different age groups - to the benefit of scientific knowledge and clinical practice." (World Association for Infant Mental Health Newsletter, May 2011)Table of ContentsForeword. List of contributors. I Introduction. I.1 A historical overview: infants, parents, and parenting from ancient times to nowadays. I.2 Definition of some major concepts. I.3 Structure of the book. I.4 References. SECTION 1 Parental Orientations Normal processes. 1 Mothers' and fathers' orientations: patterns of pregnancy, parenting and the bonding process (Joan Raphael-Leff). 1.1 Introduction. 1.2 Pregnancy and the 'placental paradigm'. 1.3 The model of maternal orientations. 1.4 Mothering. 1.5 Postnatal disturbances. 1.6 Contagious arousal. 1.7 Paternal orientations. 1.8 Conclusion. 2 The competent fetus (Sam Tyano and Miri Keren). 2.1 Introduction. 2.2 Continuity from intrauterine life to infancy. 2.3 The competent fetus and its receptive sensorial capacities. 2.4 Fetuses remember and therefore can learn . . . . 2.5 Fetuses can feel pain. 2.6 Fetal psychology: an emerging domain. 2.7 Conclusion: the fetus can no longer be thought as a 'witless tadpole'. Challenging pregnancies. 3 Single parenthood: its impact on parenting the infant (Sam Tyano and Miri Keren). 3.1 Introduction. 3.2 Single-parent families come in a variety of profiles. 3.3 Single parenthood as risk factor for parental mental health. 3.4 Risk factors for mental health problems among single mothers. 3.5 Single-father families versus single-mother families. 3.6 Single custodial parenthood. 3.7 Psychological characteristics of single mothers by choice. 3.8 A double-edge risk situation: being a single parent of an infant at risk. 3.9 Clinical implications. 3.10 Summary. 4 Surrogate mothers (Olga B.A. van den Akker). 4.1 Introduction. 4.2 Characteristics, motivations and experiences. 4.3 Attachment, bonding and pregnancy. 4.4 Relinquishing the baby and the social context. At-risk pregnancies. 5 The impact of stress in pregnancy on the fetus, the infant, and the child (Miri Keren). 5.1 Introduction. 5.2 Data from animal studies. 5.3 Human studies of the impact of maternal stress on offspring. 5.4 Discussion. 5.5 Conclusion: implications for social health policy. 6 Unintended pregnancies (Myriam Szejer). 6.1 Introduction. 6.2 The insistence of desire. 6.3 Abortion. 6.4 Rape, incest and denials of pregnancy. 6.5 Pregnancy and mental illness. 7 Clinical challenges of adolescent motherhood (George M. Tarabulsy, Annie Bernier, Simon Larose, Fanie Roy, Caroline Moisan and Claire Baudry). 7.1 Introduction. 7.2 Early challenges faced by young mothers. 7.3 Adolescent mother-infant interaction and the elaboration of attachment. 7.4 Intervention with adolescent mothers and their infants. 8 Psychopathological states in the pregnant mother (Carol Henshaw MD FRCPsych FHEA). 8.1 Introduction. 8.2 General guidelines. 9 When something goes wrong with the fetus: rights, wrongs and consequences (Julio Arboleda-Florez). 9.1 Reproduction and threats to the unborn. 9.2 The rights of the fetus and of the newborn. 9.3 Parental reactions. 9.4 The fate of persons with developmental disabilities. 10 Multiple fetuses pregnancy and other medical high-risk pregnancies (Micheline Garel, Elise Charlemaine and Sylvain Missonier). 10.1 Medical high-risk pregnancies: definition. 10.2 Psychological aspects of multiple pregnancies. 10.3 Pregnancy and HIV, a public health problem. Assessment of prenatal parenting. 11 Prenatal self-report questionnaires, scales and interviews (Massimo Ammaniti and Renata Tambelli). 11.1 Introduction. 11.2 Semi-structured interviews. 11.3 Self-report questionnaires and scales. 11.4 Inventories. 12 Observational tool: the prenatal Lausanne Trilogue Play (Elisabeth Fivaz-Depeursinge, France Frascarolo and Antoinette Corboz-Warnery). 12.1 Introduction. 12.2 The Lausanne Trilogue Play paradigm. 12.3 The prenatal LTP. 12.4 Discussion. Treatment of abnormal states during pregnancy. 13 Psychopharmacological treatments during pregnancy: risks and benefits for the mother and her infant (Martin St-Andre and Brigitte Martin). 13.1 Introduction. 13.2 Depression and anxiety during pregnancy. 13.3 Bipolar disorder. 13.4 Schizophrenia. 13.5 Post-partum psychosis. 14 Psychotherapeutic, psychosocial, individual and family interventions for abnormal states during pregnancy (Prabha S. Chandra, Geetha Desai and Veena A. Satyanarayana). 14.1 Introduction. 14.2 Maternal-fetal attachment disorders. 14.3 Anxiety disorders. 14.4 Eating disorders. 14.5 Depression. 14.6 Suicide. 14.7 Substance use. SECTION 2 Delivery and birth. 15 Perinatal loss: its immediate and long-term impact on parenting (Miri Keren). 15.1 Introduction. 15.2 Historical and cultural perspectives. 15.3 Psychological effects of perinatal death on mothers. 15.4 Psychological effects of perinatal death on fathers. 15.5 Impact of perinatal loss on the couple. 15.6 Impact of perinatal loss on the subsequent pregnancy. 15.7 Clinical implications. SECTION 3 Parenting of the infant during the first year of life Normal processes. 16 Transition to parenthood (Antoine Guedeney and Susana Tereno). 16.1 Introduction. 16.2 Pregnancy and emotional upheaval: risks and resiliency. 16.3 The psychological unfolding of pregnancy. 16.4 Psychopathology in pregnancy. 16.5 Prevention and early intervention. 16.6 CAPEDP-Attachment: a French project to promote parental skills and decrease disorganized attachment. 17 Role of parenting in the development of the infant's interpersonal abilities (Deborah Weatherston and Hiram E. Fitzgerald). 17.1 Introduction. 17.2 Transformative theoretical concepts of human relationships. 17.3 Infant mental health service structure. 18 Welcoming a stranger: cultural and social aspects of parenting (Nathalie Zajde and Catherine Grandsard). 18.1 Introduction. 18.2 Jimmy. 18.3 Ethnopsychiatry. 18.4 Ethnopsychiatric therapy sessions. 18.5 Treatment. 18.6 Psychotherapy and diplomacy. 18.7 The conflict between the two families. 18.8 Sorcery: from the Antilles to the Congo. 18.9 Pentecostal churches in the Congo. 18.10 Misunderstanding no. 1. 18.11 The Bakongo kinship and parenting system. 18.12 Misunderstanding no. 2. 18.13 To whom does the child belong? 18.14 Back to the treatment. 18.15 Identifying baby Jimmy. 18.16 Epilogue. 19 Filicide: parents who murder their child (Sam Tyano and John Cox). 19.1 Introduction. 19.2 Prevalence of filicide among Western societies. 19.3 Filicide and the child's age. 19.4 Filicide and parent's gender. 19.5 Parental motivations for committing filicide: at the psychiatric level. 19.6 Parental motivations for committing filicide: at the psychodynamic level. 19.7 Characteristics of the child at risk for filicide. 19.8 Clinical implications. Parental risk factors for parenthood. 20 Maternal postnatal mental disorder: how does it affect the young child? (John Cox and Joanne Barton). 20.1 Introduction. 20.2 Postnatal mental illness: immediate effect on parenting. 20.3 Mother-infant relationships. 20.4 Risk and resilience. 20.5 Infant outcome and child development. 20.6 Child mental health problems. 20.7 Child abuse and neglect. 20.8 Family aspects. 20.9 Considering the child in the management of maternal mental illness. 21 Psychopathological states in the father and their impact on parenting (Michael W. O'Hara and Sheehan D. Fisher). 21.1 Introduction. 21.2 Prevalence of psychiatric disorders in men. 21.3 Paternal psychopathology and child internalizing and externalizing problems. 21.4 How depressive symptoms may affect parenting. 21.5 Paternal psychopathology and parenting. 21.6 Summary. 21.7 Research agenda. 22 The impact of trauma on parents and infants (Joy D. Osofsky, Howard J. Osofsky and Erika L. Bocknek). 22.1 Introduction. 22.2 The problem of abuse and neglect. 22.3 Other trauma exposure in young children. 22.4 Lessons learned. 23 Substance problems: bridging the gap between infant and adult (Ilana Crome). 23.1 Introduction. 23.2 The prevention and policy framework. 23.3 Epidemiology: the magnitude of the problem. 23.4 Health and welfare: context and consequences. 23.5 Assessment and treatment: uniting families. 23.6 Specific interventions for pregnant substance misusers. 23.7 Pharmacological treatments for pregnant substance misusers. 23.8 Catalysing change by implementation of research: service models. Environmental risk factors for parenthood. 24 Foster parenthood (Yvon Gauthier). 24.1 Introduction. 24.2 Foster children symptomatology. 24.3 The use of attachment theory. 24.4 Foster children's special needs. 24.5 How to help foster parents to provide best care for the fostered child. 24.6 Kin vs. non-kin foster parents. 24.7 Visits to the biological parents. 24.8 Need for permanency. 25 Parenting the chronically ill infant (Barbara G. Melamed). 25.1 Introduction. 25.2 Asthma. 25.3 Congenital heart disease. 25.4 Cystic fibrosis. 25.5 Very low birth weight infants. 25.6 Conclusions and future studies. 26 Parenting an infant born of rape (Frances Thomson Salo). 26.1 Case vignette 1. 26.2 Case vignette 2. 26.3 Case vignette 3. 26.4 Introduction. 26.5 Context. 26.6 Outcomes of pregnancy. 26.7 Perinatal period. 26.8 Maternal representation of the infant. 26.9 Maternal attachment. 26.10 Infant attachment. 26.11 Representations of the father and disclosure to the infant. 26.12 Adoptive and foster parenting. 26.13 Siblings. 26.14 Being parented in ongoing difficulty. 26.15 Support and therapeutic intervention for the family. 26.16 The infant's view of their life. 27 Parenting an infant with a disability (Sheila Hollins, Stella Woodward and Kathryn Hollins). 27.1 Introduction. 27.2 Parental expectations. 27.3 Antenatal diagnosis. 27.4 Case vignette 1. 27.5 Case vignette 2. 27.6 Postnatal diagnosis. 27.7 Case vignette 3. 27.8 Case vignette 4. 27.9 Diagnostic uncertainty. 27.10 Parental responses. 27.11 Parent-infant relationship development. 27.12 Case vignette 5. 27.13 Case vignette 6. 27.14 Depression in parents of children with a disability. 27.15 Responses of family, friends and wider society. 27.16 Economic and social implications. 27.17 Positive implications. 27.18 Supporting parents. 28 Being a parent with a disability (Adil Akram and Sheila Hollins). 28.1 Being a disabled parent. 28.2 The UK context. 28.3 Parents with physical disability. 28.4 Parents with intellectual disability. 28.5 Parents with mental illness. 28.6 A recovery perspective on disabled parents with mental illness. 28.7 The social model of disability. 28.8 Cultural representations of parents with disabilities. 28.9 UK policy perspectives. 28.10 Solutions to support disabled adults as parents. 28.11 Involving disabled parents in research. 29 Parenthood: the impact of immigration (Olivier Taıeb, Thierry Baubet, Dalila Rezzoug and Marie Rose Moro). 29.1 Introduction. 29.2 The ingredients of parenthood. 29.3 Pregnancy and childbirth in exile. 29.4 The infant, a cultural being. 29.5 Conclusions: parents in exile. 29.6 References. 30 Parenting and poverty: a complex interaction (Mark Tomlinson). 30.1 Introduction. 30.2 Poverty. 30.3 Upstream and downstream factors. 30.4 Parenting and its determinants. 30.5 Parenting and poverty. 30.6 Maternal depression. 30.7 Poverty, parenting, depression and infant attachment. 30.8 Malnutrition and non-organic failure to thrive. Assessment of parenthood. 31 Assessment of parenting (Marc H. Bornstein and Magdalen Toole). 31.1 Introduction. 31.2 Self-report measures. 31.3 Reports by others. 31.4 Observational methods. 31.5 Experimental testing. 31.6 Parental influence. 32 Principles of effective co-parenting and its assessment in infancy and early childhood (James P. McHale and Elisabeth Fivaz-Depeursinge). 32.1 Introduction. 32.2 What is effective co-parenting? 32.3 Co-parenting as a triangular concept. 32.4 Co-parenting and division of labor. 32.5 Co-parenting and children's adjustment. 32.6 What do mental health professionals need to know? The essentials. 32.7 Instruments of choice: observational, interview and self-report survey data. 33 Legal assessment of parenting competency (Jean-Victor P. Wittenberg). 33.1 Introduction. 33.2 Definitions of maltreatment. 33.3 Assessment is an intervention. 33.4 Infants and toddlers are a special group. 33.5 Models of parenting capacity assessment. 33.6 Core competencies for professionals doing parenting capacity assessments with infants. Treatment of dysfunctional parenting. 34 Psychotropic drugs and lactation: to nurse or not to nurse (Zivanit Ergaz and Asher Ornoy). 34.1 Drug excretion into breast milk: general considerations. 34.2 Benzodiazepines. 34.3 Phenothiazines. 34.4 Butirophenones. 34.5 Atypical neuroleptics. 34.6 Antimanic drugs. 34.7 Anticonvulsants that are also mood-stabilizers. 34.8 Central nervous system stimulants. 34.9 Tricyclic antidepressants. 34.10 Tetracyclic antidepressants. 34.11 Selective serotonin reuptake inhibitors. 34.12 Serotonin and norepinephrine reuptake inhibitors. 34.13 Noradrenaline reuptake inhibitors. 35 Parent-infant psychotherapies and indications for inpatient versus outpatient treatments (Kaija Puura and Palvi Kaukonen). 35.1 Introduction. 35.2 Different forms of parent-infant psychotherapy. 35.3 Indications for inpatient versus outpatient treatment. 35.4 When parents reject treatment. Pathological parenting: from the infant's perspective. 36 The symptomatology of a dysfunctional parent-infant relationship (Campbell Paul). 36.1 Introduction. 36.2 'Good-enough' parenting. 36.3 Parenting in the context of mental illness. 36.4 Qualities of infant-parent interaction. 36.5 Assessing infant-parent interaction. 36.6 The infant response in the context of a dysfunctional relationship. 36.7 Implications for prevention and intervention. 36.9 Acknowledgements. Concluding chapter. 37 Mental health of parents and infant health and development in resource-constrained settings: evidence gaps and implications for facilitating 'good-enough parenting' in the twenty-first-century world (Jane Fisher, Atif Rahman, Meena Cabral de Mello, Prabha S. Chandra and Helen Herrman). 37.1 Introduction. 37.2 Social model of mental health. 37.3 Parenting and mothers' social position. 37.4 Human rights, mental health and child health and development. 37.5 Promotion of infant health and development and prevention of maternal mental health problems. 37.6 Preventing and ameliorating maternal mental health problems and potential benefits for infant health and development. 37.7 Addressing the social determinants of compromised early childhood development and maternal mental health problems. 37.8 Implications for facilitating 'good-enough parenting' in the communities of the twenty-first century. 37.9 Conclusion. 37.10 References 440 Index.

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Book SynopsisGenetic and Evolutionary Computation: Medical Applications provides an overview of the range of GEC techniques being applied to medicine and healthcare in a context that is relevant not only for existing GEC practitioners but also those from other disciplines, particularly health professionals. There is rapidly increasing interest in applying evolutionary computation to problems in medicine, but to date no text that introduces evolutionary computation in a medical context. By explaining the basic introductory theory, typical application areas and detailed implementation in one coherent volume, this book will appeal to a wide audience from software developers to medical scientists. Centred around a set of nine case studies on the application of GEC to different areas of medicine, the book offers an overview of applications of GEC to medicine, describes applications in which GEC is used to analyse medical images and data sets, derive advanced models, and suggest diagnoses and Table of ContentsAbout the Editors. List of Contributors. 1 Introduction. 2 Evolutionary Computation: A Brief Overview (Stefano Cagnoni and Leonardo Vanneschi). 2.1 Introduction. 2.2 Evolutionary Computation Paradigms. 2.2.1 Genetic Algorithms. 2.2.2 Evolution Strategies. 2.2.3 Evolutionary Programming. 2.2.4 Genetic Programming. 2.2.5 Other Evolutionary Techniques. 2.2.6 Theory of Evolutionary Algorithms. 2.3 Conclusions. 3 A Review of Medical Applications of Genetic and Evolutionary Computation (Stephen L. Smith). 3.1 Medical Imaging and Signal Processing. 3.1.1 Overview. 3.1.2 Image Segmentation. 3.1.3 Image Registration, Reconstruction and Correction. 3.1.4 Other Applications. 3.2 Data Mining Medical Data and Patient Records. 3.3 Clinical Expert Systems and Knowledge-based Systems. 3.4 Modelling and Simulation of Medical Processes. 3.5 Clinical Diagnosis and Therapy. 4 Applications of GEC in Medical Imaging. 4.1 Evolutionary Deformable Models for Medical Image Segmentation: A Genetic Algorithm Approach to Optimizing Learned, Intuitive, and Localized Medial-based Shape Deformation (Chris McIntosh and Ghassan Hamarneh). 4.1.1 Introduction. 4.1.1.1 Statistically Constrained Localized and Intuitive Deformations. 4.1.1.2 Genetic Algorithms. 4.1.2 Methods. 4.1.2.1 Population Representation. 4.1.2.2 Encoding the Weights for GAs. 4.1.2.3 Mutations and Crossovers. 4.1.2.4 Calculating the Fitness of Members of the GA Population. 4.1.3 Results. 4.1.4 Conclusions. 4.2 Feature Selection for the Classification of Microcalcifications in Digital Mammograms using Genetic Algorithms, Sequential Search and Class Separability (Santiago E. Conant-Pablos, Rolando R. Hernández-Cisneros, and Hugo Terashima-Marín). 4.2.1 Introduction. 4.2.2 Methodology. 4.2.2.1 Pre-processing. 4.2.2.2 Detection of Potential Microcalcifications (Signals). 4.2.2.3 Classification of Signals into Microcalcifications. 4.2.2.4 Detection of Microcalcification Clusters. 4.2.2.5 Classification of Microcalcification Clusters into Benign and Malignant. 4.2.3 Experiments and Results. 4.2.3.1 From Pre-processing to Signal Extraction. 4.2.3.2 Classification of Signals into Microcalcifications. 4.2.3.3 Microcalcification Clusters Detection and Classification. 4.2.4 Conclusions and Future Work. 4.3 Hybrid Detection of Features within the Retinal Fundus using a Genetic Algorithm (Vitoantonio Bevilacqua, Lucia Cariello, Simona Cambo, Domenico Daleno, and Giuseppe Mastronardi). 4.3.1 Introduction. 4.3.2 Acquisition and Processing of Retinal Fundus Images. 4.3.2.1 Retinal Image Acquisition. 4.3.2.2 Image Processing. 4.3.3 Previous Work. 4.3.4 Implementation. 4.3.4.1 Vasculature Extraction. 4.3.4.2 A Genetic Algorithm for Edge Extraction. 4.3.4.3 Skeletonization Process. 4.3.4.4 Experimental Results. 5 New Analysis of Medical Data Sets using GEC. 5.1 Analysis and Classification ofMammography Reports using Maximum Variation Sampling (Robert M. Patton, Barbara G. Beckerman, and Thomas E. Potok). 5.1.1 Introduction. 5.1.2 Background. 5.1.3 Related Works. 5.1.4 Maximum Variation Sampling. 5.1.5 Data. 5.1.6 Tests. 5.1.7 Results & Discussion. 5.1.8 Summary. 5.2 An Interactive Search for Rules in Medical Data using Multiobjective Evolutionary Algorithms (Daniela Zaharie, D. Lungeanu, and Flavia Zamfirache). 5.2.1 Medical Data Mining. 5.2.2 Measures for Evaluating the Rules Quality. 5.2.2.1 Accuracy Measures. 5.2.2.2 Comprehensibility Measures. 5.2.2.3 Interestingness Measures. 5.2.3 Evolutionary Approaches in Rules Mining. 5.2.4 An Interactive Multiobjective Evolutionary Algorithm for Rules Mining. 5.2.4.1 Rules Encoding. 5.2.4.2 Reproduction Operators. 5.2.4.3 Selection and Archiving. 5.2.4.4 User Guided Evolutionary Search. 5.2.5 Experiments in Medical Rules Mining. 5.2.5.1 Impact of User Interaction. 5.2.6 Conclusions. 5.3 Genetic Programming for Exploring Medical Data using Visual Spaces (Julio J. Valdés, Alan J. Barton, and Robert Orchard). 5.3.1 Introduction. 5.3.2 Visual Spaces. 5.3.2.1 Visual Space Realization. 5.3.2.2 Visual Space Taxonomy. 5.3.2.3 Visual Space Geometries. 5.3.2.4 Visual Space Interpretation Taxonomy. 5.3.2.5 Visual Space Characteristics Examination. 5.3.2.6 Visual Space Mapping Taxonomy. 5.3.2.7 Visual Space Mapping Computation. 5.3.3 Experimental Settings. 5.3.3.1 Implicit Classical Algorithm Settings. 5.3.3.2 Explicit GEP Algorithm Settings. 5.3.4 Medical Examples. 5.3.4.1 Data Space Examples. 5.3.4.2 Semantic Space Examples. 5.3.5 Future Directions. 6 Advanced Modelling, Diagnosis and Treatment using GEC. 6.1 Objective Assessment of Visuo-spatial Ability using Implicit Context Representation Cartesian Genetic Programming (Michael A. Lones and Stephen L. Smith). 6.1.1 Introduction. 6.1.2 Evaluation of Visuo-spatial Ability. 6.1.3 Implicit Context Representation CGP. 6.1.4 Methodology. 6.1.4.1 Data Collection. 6.1.4.2 Evaluation. 6.1.4.3 Parameter Settings. 6.1.5 Results. 6.1.6 Conclusions. 6.2 Towards an Alternative to Magnetic Resonance Imaging for Vocal Tract Shape Measurement using the Principles of Evolution (David M. Howard, Andy M. Tyrrell, and Crispin Cooper). 6.2.1 Introduction. 6.2.2 Oral Tract Shape Evolution. 6.2.3 Recording the Target Vowels. 6.2.4 Evolving Oral Tract Shapes. 6.2.5 Results. 6.2.5.1 Oral Tract Areas. 6.2.5.2 Spectral Comparisons. 6.2.6 Conclusions. 6.3 How Genetic Algorithms can Improve Pacemaker Efficiency (Laurent Dumas and Linda El Alaoui). 6.3.1 Introduction. 6.3.2 Modeling of the Electrical Activity of the Heart. 6.3.3 The Optimization Principles. 6.3.3.1 The Cost Function. 6.3.3.2 The Optimization Algorithm. 6.3.3.3 A New Genetic Algorithm with a Surrogate Model. 6.3.3.4 Results of AGA on Test Functions. 6.3.4 A Simplified Test Case for a Pacemaker Optimization. 6.3.4.1 Description of the Test Case. 6.3.4.2 Numerical Results. 6.3.5 Conclusion. 7 The Future for Genetic and Evolutionary Computation in Medicine: Opportunities, Challenges and Rewards. 7.1 Opportunities. 7.2 Challenges. 7.3 Rewards. 7.4 The Future for Genetic and Evolutionary Computation in Medicine. Appendix: Introductory Books and Useful Links. Index.

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Book SynopsisThe 'Recovery Movement' is an attempt to consider people with mental illnesses first and foremost as individuals. Governments and planning bodies have made commitments to develop mental health policy and services towards recovery as a treatment option.Trade Review"Overall, this book would be useful for students and practitioners who are familiar with the literature on recovery." (Mental Health Practice, 1 November 2011) "This is an important contribution from international leads, which offers the reader interested in recovery an awareness of its substantial ethical and political foundations and the need to sustain a civil rights perspective." (British Journal of Psychiatry, 2011) "Just as Tuke and the late 18th century reformers were bold in their vision of moral treatment, we need to be bold about recovery. Davidson et al. provide some of the conceptual and political framework for that vision, and it is these aspects of their book that will help practitioners build recovery focused mental health services." (Metapsychology, February 2011)"This book should be required reading for any young professional entering the mental health field. Education in the history of the development of applied psychology will often give the reader a self-satisfied glow. We know so much more now than in the days of insulin shock therapy, hydrotherapy, and psychoanalysis. The Roots of the Recovery Movement in Psychiatry: Lessons Learned drives home the point that we can learn as much from the successes of our predecessors as we can from their mistakes". (American Psychological Association, 17 November 2010) "This book is a wonderful contribution to the literature attempting to untangle the web of what recovery truly means to individuals and how care can continue to evolve to meet the fundamental rights of human beings with serious mental illnesses." (Psychiatric Rehabilitation Journal, Summer 2010)"However the book is not limited to the study of psychiatry- it illustrates how psychiatry has been influenced by other disciplines such as philosophy, sociology, psychology, political theory, and civil rights. This is the major strength of this book." (British Journal of Wellbeing, September 2010)Table of ContentsForeword Acknowledgements 1 Introduction 1.1 What is the recovery movement in psychiatry? 1.2 Rationale for the book 1.3 From traitement moral to moral treatment 1.4 Reciprocity in community-based care 1.5 The everyday and interpersonal context of recovery 1.6 Closing the hospital 1.7 The rights and responsibilities of citizenship 1.8 Agency as a basis for transformation 1.9 Why these figures and not others? 1.10 Conclusion 2 FromTraitement Moral to Moral Treatment 2.1 The birth of psychiatry as a medical speciality 2.2 Philippe Pinel and Jean-Baptise Pussin 2.3 Traitement moral 2.4 Pinel’s psychological interventions 2.5 The Retreat at York 2.6 Moral treatment or moral management? 2.7 From treatment to education 2.8 Re-shaping character 2.9 The demise of moral treatment 2.10 Summary of lessons learned 3 Reciprocity in Community-based Care 3.1 The advocacy of dorothea dix 3.2 The legacy of dorothea dix 3.3 Jane Addams’ community alternative 3.4 A series of unfortunate, but influential, events 3.5 The founding of the first american ‘settlement’ 3.6 Forty years at hull-house 3.7 Distilling the active ingredients 3.8 Interventions with individuals 3.9 Interventions with collectives 3.10 Applications to mental health 3.11 Summary of lessons learned 4 The Everyday and Interpersonal Context of Recovery 4.1 The birth of psychiatry as a community-based practice 4.2 Beyond the illness paradigm (by John Strauss, part 1) 4.3 Growing up inside meyer’s ‘common sense’ psychiatry (by John Strauss, part 2) 4.4 Subjectivity and the person (by John Strauss, part 3) 4.5 Blending science and art in a human science (by John Strauss, part 4) 4.6 From a psychiatry based in death to a psychiatry based in life 4.7 Problems in everyday living and their resolution 4.8 Opportunity and occupation 4.9 The interpersonal context of recovery 4.10 Summary of lessons learned 5 Closing the Hospital 5.1 The failure of the asylum 5.2 Erving Goffman and the presentation of self 5.3 The hospital as ‘total institution’ 5.4 Franco Basaglia and the Italian mental health reform movement 5.5 De-institutionalization the Italian way 5.6 Bracketing the illness 5.7 ‘Freedom is therapeutic’ 5.8 Avoiding the re-creation of the asylum in the community 5.9 Social inclusion 5.10 Summary of lessons learned 6 The Rights and Responsibilities of Citizenship 6.1 Recovery as a civil rights movement 6.2 The incomplete world of Martin Luther King, Jnr 6.3 Can rights be given? 6.4 Recovery delayed is recovery denied 6.5 Colour blindness and capitalism 6.6 The complete subject of Gilles Deleuze 6.7 Oedipus and anti-oedipus 6.8 Schizophrenic speech and Watergate 6.9 Community inclusion vs community integration 6.10 Summary of lessons learned 7 Agency as the Basis for Transformation 7.1 The need for a new conceptual framework 7.2 Beyond de-institutionalization and community tenure 7.3 Rights and recovery 7.4 The capabilities approach of Amartya Sen 7.5 Applying a capabilities approach to the work of transformation 7.6 Human agency and mediation: the work of Lev Vygotsky 7.7 Action theory, the zone of proximal development and scaffolding 7.8 Applying activity analysis: the case of fossilized behaviour 7.9 Applying activity analysis: using the zone of proximal development 7.10 Summary of lessons learned 8 Conclusion References Index

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Book SynopsisIn recent years, many factors have combined to change the operating environment of the international pharmaceutical industry leading to greater specialization and sophistication. This work deals with this topic.Table of ContentsList of Contributors. Preface. Preface to the First Edition. Acknowledgements. I: Background to Medicines Research and Development. Pharmaceutical Medicine—A Specialist Discipline (F. Gabbay). The Contribution of Academic Clinical Pharmacology to Medicine Research (C. George). A Career in Drug Discovery (D. Ellis). II: Careers in Pre-Clinical and Clinical Research. A Career in Clinical Pharmacology (R. Yates). Career Opportunities for Physicians in the Pharmaceutical Industry (B. Spilker). The Clinical Research Associate (G. Hayes). Clinical Trial Administrator and Study Site Co-ordinator—Key Roles in Clinical Research (N. Murgatroyd, et al.). Statisticians in the Pharmaceutical Industry (C. Hilton and T. Lewis). Careers in Data Management (S. Varley). Working in a Contract Research Organisation (J. Barrett). III: Careers in Sales and Marketing. A Career in Product Management (R. Carlisle). A Career in Medical Sales and Medical Sales Management (R. Carlisle). IV: General Careers with the Pharmaceutical Industry. The Role of the Pharmacist in Healthcare (D. Jordan). Careers for Nurses with the Pharmaceutical Industry (J. Kenkre). The Toxicologist in Pharmaceutical Medicine (G. Diggle). A Career in Clinical Quality Assurance (R. Hattemer-Apostel). A Career in Product Registration and Regulatory Affairs (P. Turmer). Careers in Drug Safety and Pharmacovigilance (P. Barnes). Careers in Medical Information (J. Taylor). Medical Writing as a Career (B. Mullinger). Career Opportunities in Medicines Regulation—The Medical Assessor (N. Baber). Pharmaceutical Law - A Growing Legal Specialty (I. Dodds-Smith) Industry Careers for Pharmacoeconomists (N. Bosanquet). Consultant in Pharmaceutical Medicine (B. Gennery). V: Career Progression. Landing that Job—Recruitment, CVs and Interviews (S. Ransom). Career Development in Pharmaceuticals (R. Stephens). Opportunities for Education and Training in the Pharmaceutical Industry (P. Stonier and G. Hayes). Useful Information. Index.

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Book SynopsisThis book is an archival reference for the evolving field of biomaterials and their applications in society, focusing on their composition, properties, characterization, chemistry and applications in bioenergy, chemicals, and novel materials and biomaterials.It has broad appeal due to the recent heightened awareness around bioenergy and biomass as potential replacements for petroleum feedstocks.The book is divided into three parts: cellulose-based biomaterials, chitin and chitosan biomaterials, and hemicelluloses and other polysaccharides. Each chapter addresses a separate biomaterial, discussing its chemical, physical, and biological attributes, and hones in on each compound''sintrinsic tunabilityfor numerous chemical transformations.In the current quest for a green economy and resources, this book will help inspire scientists towardsnovel sources for chemicals, materials, andenergy in the years to come.Table of ContentsForeword vii Preface ix Contributors xi 1 Recent Advances in Cellulose Chemistry 1 Thomas Heinze and Katrin Petzold-Welcke 2 Cellulosic Aerogels 51 Falk Liebner, Emmerich Haimer, Antje Potthast, and Thomas Rosenau 3 Nanocelluloses: Emerging Building Blocks for Renewable Materials 105 Youssef Habibi and Lucian A. Lucia 4 Interactions of Chitosan with Metals for Water Purification 127 Mohammed Rhazi, Abdelouhad Tolaimate, and Youssef Habibi 5 Recent Developments in Chitin and Chitosan Bio-Based Materials Used for Food Preservation 143 Véronique Coma 6 Chitin and Chitosan as Biomaterial Building Blocks 177 JoséF. Louvier-Hernández and Ram B. Gupta 7 Chitosan Derivatives for Bioadhesive/Hemostatic Applications: Chemical and Biological Aspects 199 Mai Yamazaki and Samuel M. Hudson 8 Chitin Nanofibers as Building Blocks for Advanced Materials 227 Youssef Habibi and Lucian A. Lucia 9 Electrical Conductivity and Polysaccharides 247 Axel Rußler and Thomas Rosenau 10 Polysaccharide-Based Porous Materials 271 Peter S. Shuttleworth, Avtar Matharu, and James H. Clark 11 Starch-Based Bionanocomposites: Processing and Properties 287 Visakh P. M., Aji P. Mathew, Kristiina Oksman, and Sabu Thomas 12 Starch-Based Sustainable Materials 307 Luc Avérous 13 The Potential of Xylans as Biomaterial Resources 331 Anna Ebringerova 14 Micro- and Nanoparticles from Hemicelluloses 367 Emmerich Haimer, Falk Liebner, Antje Potthast, and Thomas Rosenau 15 Nonxylan Hemicelluloses as a Source of Renewable Materials 387 David Plackett and Natanya Hansen Index 409

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Book Synopsis* The first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world s leading authorities in abdominal imaging, Richard C. Semelka MD.Table of ContentsList of Contributors, vii Preface, ix 1 The Cross-Sectional Anatomy of the Liver and Normal Variations1Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 2 The Cross-Sectional Imaging Techniques and Diagnostic Approach 15Ersan Altun and Richard C. Semelka 3 Safety of MRI and CT 63Ersan Altun and Richard C. Semelka 4 Cystic Diseases of the Liver 73Ersan Altun, Mohamed, El-Azzazi, Richard C. Semelka, and Miguel Ramalho 5 Benign Solid Liver Lesions 101Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 6 Liver Metastases 137Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Miguel Ramalho 7 Hepatocellular Carcinoma 161Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 8 Rare Primary and Secondary Tumors of the Liver 181Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 9 Cholangiocarcinoma 193Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Miguel Ramalho 10 Infectious Diseases of the Liver, 201Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 11 Chronic Hepatitis and Liver Cirrhosis 219Ersan Altun, Mohamed El-Azzazi, Richard C. Semelka, and Mamdoh AlObaidy 12 Hepatic Fat and Iron Deposition 241Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 13 Inflammatory Liver Diseases 255Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 14 Vascular Disorders of the Liver 267Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 15 Post-treatment Changes in the Liver 285Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka 16 Liver Trauma 301Ersan Altun, Mohamed El-Azzazi, and Richard C. Semelka Index 305

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Book SynopsisSets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient''s genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual''s genome affects those processes. The book''s eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literTable of ContentsPREFACE vii CONTRIBUTORS ix CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1 Marianne K. DeGorter and Richard B. Kim CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13 Liangfu Chen and Joseph W. Polli CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39 Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73 Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109 Toshihisa Ishikawa and Yoshihide Hayashizaki CHAPTER 6 OATP1A2, OAT1, AND OAT3 125 Rommel G. Tirona CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141 J¨org K¨onig and Martin F. Fromm CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171 Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini CHAPTER 9 MATE (SLC47) FAMILY 209 Atsushi Yonezawa and Ken-ichi Inui CHAPTER 10 PEPT (SLC15A) FAMILY 223 Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243 M´ýriam Molina-Arcas and Marc¸al Pastor-Anglada CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271 Ingolf Cascorbi CHAPTER 13 BSEP (ABCB11) 295 Bruno Stieger and Gerd A. Kullak-Ublick CHAPTER 14 BCRP (ABCG2) 311 Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345 Anne T. Nies CHAPTER 16 MRP4 (ABCC4) 365 Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz CHAPTER 17 MRP8 (ABCC11) 387 Yu Toyoda and Toshihisa Ishikawa CHAPTER 18 FUTURE PERSPECTIVES 401 Toshihisa Ishikawa and Joseph Ware INDEX 417

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Book SynopsisMaxillary sinus elevation, followed by placement of a wide variety of grafting materials, has been the generally accepted surgical protocol for the development of bone in the sinus cavity.Table of ContentsContributors vii Acknowledgments ix Introduction xi Chapter 1 Anatomy and Physiology of the Maxillary Sinus 1Harold A. DeHaven, Jr. Chapter 2 The Applications and Limitations of Conventional Radiographic Imaging Techniques 9Hua-Hong Chien and Curtis S.K. Chen Chapter 3 The Applications and Limitations of Advanced (3-Dimensional) Radiographic Imaging Techniques 31Chih-Jaan Tai, Dimitris N. Tatakis, and Hua-Hong Chien Chapter 4 Conventional Instruments Preparation and Preclinical Training of the Lateral Window Technique 57Daniel W.K. Kao Chapter 5 Clinical Procedures of the Lateral Window Technique 67Daniel W.K. Kao Chapter 6 Avoiding and Managing Complications for the Lateral Window Technique 79Paul A. Levi and Eduardo Marcuschamer Chapter 7 Advanced Techniques of the Lateral Window Technique 105Daniel W.K. Kao and Mana K. Nejadi Chapter 8 Basic Instruments and Materials of the Transalveolar Approach: Osteotome Technique 113Daniel W.K. Kao and Elana E. Walker Chapter 9 Clinical Procedures of the Transalveolar Osteotome Approach 117Daniel W.K. Kao Chapter 10 Postoperation Management of the Transalveolar Osteotome Approach 127Gail G. Childers Chapter 11 Advanced Techniques of the Transalveolar Approach 135Daniel W.K. Kao Chapter 12 Decision Tree for Maxillary Sinus Elevation Options 149David Minjoon Kim and Daniel Kuan-te Ho Chapter 13 Choices of Bone Graft Materials 157David Minjoon Kim and Daniel Kuan-te Ho Chapter 14 Review of Dental Implant Success and Survival Rates 165Wai S. Cheung Index 179

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Book SynopsisEdited by members of the American Society for Adolescent Psychiatry, this is a practical guide to the management of an adolescent drug use and addiction. It provides the knowledge and tools for successful prevention and intervention efforts in adolescents.Trade Review“In conclusion, this book provides a useful overview of the broad range of issues relevant to working with adolescent addiction. It will be particularly helpful for psychiatrists and other medical professionals who have little experience working with this population by way of alerting them to treatment related issues for consideration.” (Early Intervention in Psychiatry, 15 April 2014) “This is an important resource for those in the field of adolescent mental health. It is not overly weighted with medical terminology, and the authors have done an excellent job of providing information with the depth that clinicians will find useful without being so clinical that the other intended readers would be lost. They have done a thorough job of providing more than just cursory information on the presentation, diagnosis, and treatment of adolescents with substance abuse problems. Although the issue of substance abuse is multifaceted, with many physiological and environmental factors at play, the book does a commendable job of organizing and outlining the evaluation and treatment modalities of substance abuse in the adolescent population.” (Doody’s, 11 October 2013) “Nevertheless, this is the best compendium of evidence in the round in this field and an excellent reference book.” (Addiction, 1 September 2013) "The wealth of information is brought together by a consummate clinician who cares profoundly for the young people who have come to him – whether for court reports or treatment – and who is determined to make a difference. The clinical eye that chose the authors and edited the whole has provided just what politicians as well as clinical and criminal justice practitioners are so often calling for – an evidence base for appropriate action. It should be widely read by those practitioners but also influence policy and improve life prospects for many, many young people." (From the Foreword by Pamela J. Taylor and John Gunn, 2012)Table of ContentsList of Contributors xi Preface xv Foreword xvii THE SCOURGE OF ADOLESCENT ADDICTION 1 Edited by Richard Rosner 1 The Scourge of Addiction: What the Adolescent Psychiatrist Needs to Know 3 Richard Rosner 2 Adolescent Addictions in the United Kingdom 9 Tahira Akbar, Alex Baldacchino, and Ilana Crome ASSESSMENT OF THE SUBSTANCE-ABUSING ADOLESCENT 25 Edited by Robert Weinstock and Manuel Lopez-Leon 3 Clinical Assessment of Addiction in Adolescents 27 FarzinYaghmaie and Robert Weinstock 4 Emergency Room and Medical Evaluation 36 Christopher William Racine and Stephen Bates Billick 5 Psychological Assessment 48 Lauren Reba-Harrelson and Daniel A. Martell 6 Cultural Assessment 61 Karen B. Rosenbaum and Roxanne M. Lewin 7 Psychosocial Assessment of the Substance-Abusing Adolescent 68 Eve Maram 8 The Neurobiology of Adolescent Addiction 78 Michael Boucher and Preetpal Sandhu 9 Psychiatric Comorbidities in Adolescent Substance Use Disorders 88 Todd Zorick 10 Toxicology of Substances of Abuse 99 Eleanor Vo and Dean De Crisce RISK AND PREVENTION 123 Edited by Avram H. Mack 11 Prevention of Adolescent Psychoactive Substance Use 125 Maria E. McGee and Avram H. Mack 12 Developmental Risks for Substance Use in Adolescence: Age as Risk Factor 132 Manuel Lopez-Leon and Jesse A. Raley 13 Genetic Risk Factors for Substance Use During Adolescence 139 Hallie A. Lightdale 14 Familial and Other Social Risk Factors in Adolescent Substance Use 147 Michael Brendler 15 Externalizing Disorders 154 Yasmin Jilla 16 Internalizing Disorders Among Adolescents: A Risk for Subsequent Substance Use 161 Tiffany G. Townsend and Dionne Smith Coker-Appiah 17 Risk due to Medical, Neurological, and Neurodevelopmental Conditions 170 Malena Banks and Matthew Biel CLINICAL CONDITIONS 177 Edited by Charles Scott 18 Adolescent Alcohol Use 179 Karen Miotto, Andia Heydari, Molly Tartter, Ellen Chang, Patrick S. Thomas and Lara A. Ray 19 Stimulants 190 John W. Tsuang and Kathleen McKenna 20 Cannabis Use Disorders 202 Jan Copeland and John Howard 21 Hallucinogens and Related Compounds 213 Charles S. Grob and Marlene Dobkin de Rios 22 Opioids and Sedative-Hypnotics 223 Ann Bruner, Asad Bokhari, and Marc Fishman 23 Nicotine Use Disorders 237 Kevin M. Gray, Matthew J. Carpenter, and Himanshu P. Upadhyaya 24 Emerging Clinical Conditions 247 Christopher R. Thompson and Lauren Reba-Harrelson TREATMENT 265 Edited by Timothy W. Fong 25 Adolescent Substance Abuse Treatment Outcomes 267 Rachel Gonzales, Mary Lynn Brecht, and Richard A. Rawson 26 Translating Evidence-Based Therapies into Outpatient Practice 271 Ara Anspikian 27 Albert Ellis’ Rational Emotive Behavior Therapy 282 Richard Rosner 28 Relapse Prevention 289 Richard Rosner 29 Adolescent Intensive Outpatient Treatment 295 Tiffany Tsai 30 Adolescent Behaviors Out of Control: An Introduction to Adolescent Residential Treatment 301 Reef Karim 31 Adolescent Group Treatments: Twelve-Step and Beyond 306 Jeremy Martinez 32 Psychopharmacology for the Addicted Adolescent 311 Timothy W. Fong 33 What’s Old is New: Motivational Interviewing for Adolescents 321 Lois T. Flaherty SPECIAL ISSUES IN ADOLESCENT ADDICTION 327 Edited by Stephen Bates Billick and Dean De Crisce 34 Substance Abuse Impact on Adolescent Brain Development 329 Adam Raff 35 Neuropsychological Effects of Substance Abuse in Adolescents 340 Diane Scheiner, Ari Kalechstein, and Wilfred G. van Gorp 36 Trauma and Adolescent Addiction 350 Michal Kunz 37 Sexual Addiction and Hypersexual Behaviors in Adolescents 362 Dean De Crisce 38 Sexting, Cybersex, and Internet Use: the Relationship Between Adolescent Sexual Behavior and Electronic Technologies 377 Abigail M. Judge and Fabian M. Saleh 39 The Therapeutic Community for the Adolescent Substance Abuser 390 Gregory C. Bunt and Virginia A. Stanick 40 Treatment Issues for Youths with Substance Abuse in Juvenile Detention 405 Eraka Bath, Le Ondra Clark, and Julie Y. Low FORENSIC CONSIDERATIONS 417 Edited by Robert Lloyd Goldstein 41 Forensic Psychiatry for Adolescent Psychiatrists: An Introduction 419 Richard Rosner 42 Ethical Considerations in Adolescent Addiction 423 Robert Weinstock 43 Informed Consent, Parental Consent, and the Right to Refuse Treatment 430 Jack A. Gottschalk and Daniel P. Greenfield 44 Third Party Liability for Supplying Adolescents with Illegal Substances 438 Daniel P. Greenfield and Jack A. Gottschalk 45 Older Adolescents in Drug Court: Hammering the Revolving Door Shut 445 Laura A. Ward 46 Confidentiality and Informed Consent Issues in Treatment for Adolescent Substance Abuse 457 Robert Lloyd Goldstein 47 Saving Adolescents 464 Richard Rosner Index 471

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Book SynopsisWritten by leading experts in the field, Cardiovascular Diseases and Health in the Older Patient covers the epidemiology, pathophysiology and management of cardiovascular disease in the older patient.Trade Review“Because it specifically addresses cardiovascular disease in the elderly this is a useful addition to the literature.” (Doody's, 9 August 2013)Table of ContentsList of Contributors, vii Foreword, ix Introduction, xi 1 Epidemiology of Heart Disease, 1 Ahmed H. Abdelhafiz 2 Cardiac Ageing and Systemic Disorders, 29 David J. Stott and Terence J. Quinn 3 Hypertension, 44 Anthony S. Wierzbicki and Adie Viljoen 4 Lipid Management, 68 Adie Viljoen and Anthony S. Wierzbicki 5 Arrhythmias, 90 Abhay Bajpai and A. John Camm 6 Hypotension, 135 Suraj Alakkassery 7 Ischaemic Heart Disease, 152 Wilbert S. Aronow 8 Heart Failure, 172 Michael W. Rich 9 Cardiac Surgery, 202 Ulrich O. von Oppell and Adam Szafranek 10 Cardiac Rehabilitation, 234 Niccol`o Marchionni, Francesco Fattirolli, Francesco Orso, Marco Baccini, Lucio A. Rinaldi and Giulio Masotti 11 Acute Stroke Care and Management of Carotid Artery Stenosis, 261 David Doig and Martin M. Brown 12 Stroke Rehabilitation, 299 Lalit Kalra 13 Communication Disorders and Dysphagia, 329 Pamela M. Enderby 14 Peripheral Arterial Disease, 345 Leocadio Rodr´ýguez-Ma ˜ nas, Marta Castro Rodr´ýguez and Cristina Alonso Bouz´on 15 Venous Thromboembolism, 366 Gordon D.O. Lowe 16 Planning Cardiovascular Investigations and Management of Older People, 376 Jennifer K. Harrison, Terence J. Quinn and David J. Stott Index, 395

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Book SynopsisThis book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the emerging question of treating children who do not yet meet diagnostic criteria for psychosis, e.g, schizophrenia or bipolar disorder, but who are deemed to be at high risk. This is an active area of debate: such children are being treated in certain centers, while others reject this completely. The book addresses the antidepressant controversy, the placebo response and unique strategies for delineating this, and ways to optimize the differential between active medication and placebo. It reviews the impact of recent American Heart Association guidelines for monitoring children on stimulants and other psychotropics. It adheres closely to DSM-IV diagnostic criteria throughout. The book describes the use of newly approved drugs such as Lexapro for treatiTrade Review “Pharmacotherapy of Child and Adolescent Psychiatric Disorders is a book to have available on your desk, not just in your library. It provides ready access to the wealth of practical information and insight for the range of health and mental health professionals. It is highly recommended for trainees and anyone who is prescribing psychotropic medications to the pediatric population and young adults.” (Journal of Clinical Psychiatry, 7 July 2012) Table of ContentsList of Contributors, xv Foreword, xix Chapter 1 Historical Perspectives on Child and Adolescent Psychopharmacology, 1 Samuel Gershon References, 4 Chapter 2 Pharmacoepidemiology of Psychotropic Medications in Youth, 7 Daniel J. Safer & Julie Magno Zito Introduction, 7 Prevalence and trends for medications prescribed for ADHD, 8 Nonstimulant medications for ADHD, 11 Antidepressant medication, 11 Antipsychotic medication, 13 Alpha-agonists, 14 Anticonvulsant "mood stabilizers", 15 Concomitant psychotropic medication, 15 Preschool psychotropic medication use, 17 International patterns of psychotropic medication for youth, 17 Conclusion, 18 References, 18 Chapter 3 Off-Label Prescribing of Drugs in Child and Adolescent Psychiatry, 25 C. Lindsay DeVane Introduction, 25 Extent of off-label prescribing, 27 Need for psychoactive drug treatments for children and adolescents, 31 Legislation supporting pediatric drug development, 33 Recommendations to follow when considering off-label prescribing, 35 References, 36 Chapter 4 The Use of Generic Drugs in Pediatric Psychopharmacology, 39 Richard I. Shader & Christopher-Paul Milne What is a generic drug?, 39 Why are we discussing generic drugs?, 39 Basic requirements for generic drugs, 40 The status of regulations regarding generic drugs and children, 41 Abbreviated new drug application (ANDA) requirements, 42 Pediatric assessments of adult drugs (history up to current status), 43 Best Pharmaceuticals for Children Act, 44 Pediatric Research Equity Act, 45 Intersection of requirements for generics and pediatric assessment, 46 Future directions, 48 Concluding thoughts, 49 References, 49 Chapter 5 Psychoactive Drug Use in Children: Basic Concepts in Clinical Pharmacology, 51 David J. Edwards Introduction, 51 Basic concepts in pharmacokinetics, 52 Dosing considerations for psychoactive drugs in children, 55 Summary, 60 References, 60 Chapter 6 Psychostimulants, 65 Steven R. Pliszka Introduction, 65 Epidemiology of stimulant use, 66 Structure and biochemical mechanism of action, 66 Neuroimaging studies of stimulant effects, 67 Studies of short-term efficacy, 72 Studies of long-term efficacy, 76 Clinical use, 79 Common side-effects, 84 Cardiovascular safety issues, 86 Growth suppression, 88 Substance use and diversion, 88 Comparison with nonstimulant treatment, 89 Treatment of comorbidity, 92 Pharmacogenetics, 93 Conclusions, 94 References, 94 Chapter 7 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors for the Treatment of Child and Adolescent Psychiatric Disorders, 105 Charlotte M. Heleniak, Tejal Kaur, Kareem D. Ghalib & Moira A. Rynn Tricyclic antidepressants (TCAs), 105 Drug interactions, contraindications, 116 Monoamine oxidase inhibitors (MAOIs), 117 General summary, 122 References, 123 Chapter 8 Selective Serotonin Reuptake Inhibitors (SSRIs), 131 Dara Sakolsky & Boris Birmaher Pharmacokinetics, 131 Initiation and titration, 133 Indications and efficacy, 134 Adverse effects, 146 Withdrawal, 149 References, 149 Chapter 9 Novel (Atypical) Antidepressants, 155 Heidi R. Bruty, Graham J. Emslie & Paul Croarkin Novel (atypical) antidepressants, 155 General overview, 155 Bupropion, 157 Duloxetine, 162 Mirtazapine, 164 Trazodone, 166 Venlafaxine, 170 Desvenlafaxine, 173 Alternative treatments, 174 Summary, 175 References, 176 Chapter 10 Antipsychotic Agents, 181 Brieana M. Rowles, John L. Hertzer & Robert L. Findling Introduction, 181 Chemical properties, 182 Typical antipsychotics, 183 Atypical antipsychotics, 186 Ethical issues: treatment of at-risk populations, 212 Conclusions, 213 References, 213 Chapter 11 Lithium, 221 Garrett M. Sparks & David A. Axelson Introduction, 221 Pharmacology, 222 Potential mechanisms of action, 222 Evidence for the use of lithium in children and adolescents, 232 Dosing and drug monitoring, 239 Contraindications, precautions, and drug interactions, 242 Side-effects, 246 References, 250 Chapter 12 Anticonvulsants Used in Child and Adolescent Psychiatric Disorders, 261 Mani Pavuluri & Tushita Mayanil Introduction, 261 Divalproex sodium, 261 Carbamazepine, 271 Oxcarbazepine, 275 Lamotrigine, 279 Gabapentin, 284 Topiramate, 285 Conclusion, 288 References, 288 Chapter 13 Anxiolytics, 301 Barbara J. Coffey & Amanda L. Zwilling Chemical properties, 301 Indications, 305 Contraindications, 320 Adverse effects, 321 Overdose, 324 Abuse/dependence, 324 Drug interactions, 325 Available preparations and cost, 325 Initiation and maintenance of treatment, 325 Management of specific side-effects, 330 How to withdraw medication, 332 References, 332 Chapter 14 Adrenergic Agents in Child and Adolescent Psychiatry, 341 Lawrence David Scahill Clonidine and guanfacine, 341 Guanfacine, 349 Beta-blockers, 355 Acknowledgements, 361 References, 361 Chapter 15 Atypical Psychopharmacologic Strategies, 365 Jess Shatkin & Aron Janssen Opiate antagonists, 365 Memantine, 368 Riluzole, 369 Secretin, 371 Topiramate, 372 Herbal medications and dietary supplements, 373 Ginkgo (Ginkgo biloba), 375 Melatonin, 381 Omega-3 fatty acids, 383 St. John's wort (Hypericum perforatum), 384 Valerian (Valeriana officinalis), 387 Conclusion, 388 References, 389 Chapter 16 Psychopharmacology in Preschool Children, 399 Mini Tandon & Joan Luby Introduction, 399 Developmental considerations, 400 Rise in psychopharmacology use, 402 Psychotherapy before psychopharmacology, 403 When psychopharmacology may be considered as a first line: pragmatic considerations, 404 Psychopharmacology in preschool disorders: administration and monitoring, 404 Off-label prescribing: special considerations, 407 Use of psychotropics in specific disorders, 408 Summary, 415 References, 415 Chapter 17 Combination Pharmacotherapy for Psychiatric Disorders in Children and Adolescents, 421 Gagan Joshi & Anna M. Georgiopoulos Bipolar disorder, 422 Major depressive disorder, 429 Attention-deficit hyperactivity disorder, 431 Obsessive-compulsive disorder, 433 Tics and Tourette's syndrome, 434 Pervasive developmental disorders, 434 Conclusion, 434 References, 435 Index, 439

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Book SynopsisSuicide Risk Management: A Manual for Health Professionals is a short, clearly written book that provides practical guidance on how to manage the suicidal or potentially suicidal patient. Written by two expert teachers, the book has been used in courses for trainee psychiatrists and for health professionals throughout the world. Feedback from participants on these courses has informed revision of the new edition. This book is of interest for all mental health professionals who come into contact with patients who present with suicide potential, i.e. all mental health professionals, as well as general health professionals who are often the first point of contact for a suicidal patient. The book opens with a review of the epidemiology, risk factors and associated aspects of suicide. It then presents two assessment tools: The Tool for Assessment of Suicide Risk (TASR) provides instruction on how to use it appropriately in the clinic. The Suicide Risk Assessment Guide (SRAG) actsTrade Review"This manual is a scholarly and comprehensive approach to suicide. Chehil and Kutcher write in a clear, organized, and engaging style that encourages the reader of any level of experience to explore their own knowledge about suicide.I highly recommend this book to health professional." (Asian Journal of Psychiatry, 2013)Table of ContentsIntroduction, vii Objectives, ix 1 The Importance of Suicide Awareness and Assessment, 1 2 Understanding Suicide Risk, 13 3 Suicide Risk Assessment, 56 4 Putting It All Together: Tool for Assessment of Suicide Risk (TASR), 88 5 Special Topics in Understanding and Evaluating Suicide Risk, 94 6 Suicide Prevention, 110 7 Suicide Intervention, 115 8 Post-suicide Intervention: Caring for Survivors, 123 9 Care for the Carer: Death of a Patient by Suicide, 130 10 Clinical Vignettes for Group or Individual Study, 135 Appendix A Tool for Assessment of Suicide Risk (TASR), 140 Appendix B 6-ITEM Kutcher Adolescent Depression Scale: KADS, 142 Appendix C My Safety Plan, 144 Index, 147

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Book SynopsisService user involvement in mental health research poses specific challenges for both researchers and service users.Trade Review“Anyone involved or wanting to become involved in service user involvement in research would find plenty to inspire and challenge in this book.” (Nursing Times, 17 September 2012) "The emphasis in the handbook is of recovery and for research to be purposeful and useful in supporting this ... Reading this as a service user/carer, it gives optimism and hope as there are many good examples of personal stories and recovery – including recovery from schizophrenia which sends out a strong message." (MHRN newsletter, July 2011) "This engaging, helpful and well-informed handbook offers a comprehensive and thorough revievw of service user involvement in mental health research, covering issues ranging from values and collaboration to control and power." (Mental Health Practice, 1 June 2011) "The book may be of interest to those wanting to understand what user involvement can mean as well as those who have experienced it and want to extend their knowledge and research skills. Its scope means that chapters are necessarily brief but references are provided to follow up on interesting debates and topics." (British Journal of Psychiatry, December 2010) "My perspective, as a researcher who works with service users, is that this is a useful resource to dip in and out of for advice about practical issues that arise when working with service users, e.g. payment. The book clearly explains what needs to be considered in paying service users. I found this advice was not readily available elsewhere when I needed it." (The Bridge Newsletter, 2011) Table of ContentsForeword. Preface. About the Editors. About the Authors. Chapter 1 History, Context and Language (Jan Wallcraft and Mary Nettle). Chapter 2 Principles and Motives (Alison Faulkner). Chapter 3 Levels and Stages (Angela Sweeney and Louise Morgan). Chapter 4 Values (Bill (KWM) Fulford and Jan Wallcraft). Chapter 5 Roles (Jasna Russo and Peter Stastny). Chapter 6 Capacity-building (Kim Hopper and Alisa Lincoln). Chapter 7 Purposes and Goals (Larry Davidson, Priscilla Ridgway, Timothy Schmutte and Maria O'Connell). Chapter 8 Topics (Paulo Del vecchio and Crystal R. Blyler). Chapter 9 Methods (Jean Campbell). Chapter 10 Service Users as Paid Researchers (Jonathan Delman and Alisa Lincoln). Chapter 11 Consultation (Virginia Minogue). Chapter 12 Collaboration (Diana Rose). Chapter 13 Control (Peter Beresford). Chapter 14 Power (Paddy McGowan, Liam Mac Gabhann, Chris Stevenson and Jim Walsh). Chapter 15 Money (Sarah Hamilton). Chapter 16 Politics (Daniel B. Fisher). Chapter 17 Good Practice Guidance (Beate Schrank and Jan Wallcraft). Index.

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Book SynopsisThis book examines the critical issues in understanding and treating depression and suicidal behavior in late life. Chapters cover the biology, psychology, epidemiology, and sociology of depression and suicidal behavior in late life.Table of ContentsCRITICAL ISSUES IN CLINICAL SCIENCE. Epidemiology and Inferences Regarding the Etiology of Late-LifeSuicide (G. Kennedy, et al.). The Epidemiology of Late-Life Depression (G. Kennedy). Biological Commonalties Among Aging, Depression, and SuicidalBehavior (L. Schneider). Suicide Among Ethnic Elders (F. Baker). THERAPEUTIC APPROACHES. Clinical Measurement of Suicidality and Coping in Late Life: ATheory of Countervailing Forces (R. Plutchik, et al.). Psychotherapeutic Approaches to the Depressed and Suicidal OlderPerson and Family (J. Richman). Biological Treatment of Severe Late-Life Depression:Pharmacotherapy and Electroconvulsive Therapy (D. Hay & L.Hay). A Brief Antidepressant Prescribing Guide for the Generalist (G.Kennedy). TOWARD A MORE INFORMED PUBLIC POLICY. Death, Dying, and Assisted Suicide (R. Coomaraswamy). The Emerging Agenda for Prevention Through Research and PublicPolicy (G. Kennedy). Indexes.

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Book SynopsisFROM PLACEBO TO PANACEA With the latest generation of psychoactive drugs, has pharmacologyat last triumphed over mental illness? A close look at worldscientific literature would suggest otherwise. The sobering truthis that many claims about the efficacy of drug therapies foreverything from depression to schizophrenia have been exaggerated.What, then, accounts for the inflated confidence clinicians and thelay public alike often have in the new generation of wonderdrugs? Find out in From Placebo to Panacea. From Placebo to Panacea is not an indictment of drug therapy.Rather, it is a reasoned analysis of the efficacy of psychoactivedrugs as compared to other forms of treatment--backed by hardempirical data. Above all, it is meant to function as a therapist''sand patient''s guide to making more informed decisions whenconsidering treatment options. The book begins with an in-depth discussion of salient problemswith standard methods of measuring the usefulness of pTable of ContentsPartial table of contents: CONCEPTUAL ISSUES. The Curse of the Placebo: Fanciful Pursuit of a Pure BiologicalTherapy (S. Fisher & R. Greenberg). Treatment Implications of Psychiatric Comorbidity (M.Greenberg). Costly Compromises: A Critique of the Diagnostic and StatisticalManual of Mental Disorders (R. Carson). EFFICACIES OF PSYCHOACTIVE DRUGS FOR ADULTS. A Critique of the Use of Neuroleptic Drugs in Psychiatry (D.Cohen). A Focused Empirical Analysis of Treatments for Panic and Anxiety(W. Danton & D. Antonuccio). EFFICACIES OF PSYCHOACTIVE DRUGS FOR CHILDREN. Are We Justified in Treating Children with PsychoactiveDrugs? (R. Fisher & S. Fisher). Stimulant Pharmacotherapy for Attention- Deficit/HyperactivityDisorders: An Analysis of Progress, Problems, and Prospects (C.Whalen & B. Henker). OVERVIEW. What Are We to Conclude About Psychoactive Drugs?: Scanning theMajor Findings (S. Fisher & R. Greenberg). Indexes.

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Book SynopsisThis volume contains information on assessing, diagnosing and treatment planning for the range of psychiatric and psychologic problems children and adolescents may experience during their development. It includes in-depth coverage of these issues and also includes decision trees for some topics, which are brief flowcharts for practitioners to follow when assessing patients for suspected problems.Table of ContentsCLINICAL ASSESSMENT. Types and Goals of Clinical Assessment (M. Dulcan). Classification Systems and Nosology (T. Achenbach). Vulnerabilities, Risk Factors, Protective Factors, and Resilience (N. Grant). Communicating with Children (J. Demb & S. Harrison). Communicating with Adolescents (R. Hendren & B. Sarvet). Engaging Parents in Clinical Processes (S. Brown). Clinical Use of Interpreters (W. Arroyo). Experimental Concepts in Clinical Assessment (K. Wells). The Ethics of Consent and Confidentiality in Clinical Practice (G. Leong & S. Eth). DECISION TREES FOR A SAMPLING OF PRESENTING PROBLEMS. Disruptive Behavior (P. Tolan & M. Kruesi). Shyness and Fearfulness (R. Mattison). Unhappiness (J. Bemporad & S. Gabel). Difficulty with Academic Performance (L. Silver & R. Ostrander). Sleep Difficulty (M. Naylor). Appetite Disturbances: Anorexia and Hyperphagia (H. Steiner). Substance Abuse (S. Jaffe & J. Gould). Suicidal Behavior (C. Pfeffer). Bizarre, Odd, and Eccentric Behavior (P. Tanguay). Enuresis (G. Fritz & R. Rockney). Encopresis (R. Rockney & O. Hagino). School Refusal (R. Klein). Lying (E. Bleiberg & S. Atkinson). Stealing (E. Bleiberg & S. Atkinson). Temper Tantrums (S. Brown & H. Reid). Speech and Language Disorders (L. Zukerman & D. Cantwell). Language Delay (J. Fischel & G. Whitehurst). Accident-Proneness (M. Sokol & N. Gray). No Friends (A. Clarkin). Runaway Behavior (J. Sargent). Involuntary Movements (B. Peterson). INITIATING ASSESSMENT. The Initial Encounter (R. King). Assessment of Dangerousness (J. Jankowski). CLINICAL HISTORY. Psychiatric History (M. Dulcan). Genetic, Prenatal, and Delivery History (L. Lotspeich). Neonatal and Infancy History (K. Minde). Preschool History (K. Minde). History of School-Age Children (R. King). Puberty and Adolescence (C. Sylvester & S. Weissman). Temperament and Personality (R. Seifer). Speech, Language, and Communication (C. Baltaxe). Health History (H. Steiner). Nutrition Assessment (P. Novak & M. Baer). Assessment of Gender and Sexual Development in Children (S. Coates & S. Wolfe. Assessment of Sexual and Gender Development in Adolescents (S. Bradley). Assessment of Conscience Development (C. Keith). Assessment of Cognitive Processes (D. Siegel). Social Communication (P. Tanguay). Family History (A. Josephson & F. Moncher). Peer and Adult Relationships (A. Clarkin). Socioeconomic Factors (E. Messinger). Legal Factors (D. Cornell). Cultural and Religious Issues (P. Muehrer). Occupational Assessment (S. Haiman & S. Greene). Vocational Assessment (E. Lang). Educational Issues (R. Ostrander & L. Silver). Trauma History (L. Terr). Disabilities History (H. Sachs). CLINICAL OBSERVATION. Observation, Interview, and Mental Status Assessment (OIM): Parent(s) (L. Arnold & P. Jensen). Observation, Interview, and Mental Status Assessment (OIM): Infants and Preschool Children (K. Minde). Observation, Interview, and Mental Status Assessment (OIM): School-Aged Children (R. King). Observation, Interview, and Mental Status Assessment (OIM): Puberty, Adolescents, and Young Adults (S. Weissman & C. Sylvester). Observation, Interview, and Mental Status Assessment (OIM): Family Unit and Subunits (A. Josephson & F. Moncher). The Home Visit (E. Messinger). The School Visit (M. Gordon). Observation, Interview, and Mental Status Assessment (OIM): Unwilling or Resistant (M. Blotcky). Observation, Interview, and Mental Status Assessment (ODM): Culturally Different from Clincian (S. Silverman & J. McDermott). Observation, Interview, and Mental Status Assessment (OIM): Possibly Abused (S. Kaplan). Observation, Interview, and Mental Status Assessment (OIM): Possibly Substance Abusing (J. Gould & S. Jaffe). Observation, Interview, and Mental Status Assessment (OIM): Slow Learning (L. Silver & R. Ostrander). Observation, Interview, and Mental Status Assessment (OIM): Physically ILL (L. Cahen & M. Jellinek). Observation, Interview, and Mental Status Assessment (OIM): Traumatized (L. Terr). Observation, Interview, and Mental Status Assessment (OIM): Violent (E. Pittel). Observation, Interview, and Mental Status Assessment (OIM): Disabled (H. Sachs). Observation, Interview, and Mental Status Assessment (OIM): Competence to Testify (K. Saywitz). Observation, Interview, and Mental Status Assessment (OIM): Competence for Independent Decision Making (P. Ash, et al.). Observation, Interview, and Mental Status Assessment (OIM): Pregnant Adolescent and Teen Parent (L. Ware). Observation, Interview, and Mental Status Assessment (OIM): Adopted (A. Sorosky & B. Sorosky). Observation, Interview, and Mental Status Assessment (OIM): Single-Parent Homes (J. Larrieu & C. Zeanah). Observation, Interview, and Mental Status Assessment (OIM): Divorce (N. Kalter). Observation, Interview, and Mental Status Assessment (OIM): Homosexual (R. Pleak & D. Anderson). Observation, Interview, and Mental Status Assessment (OIM): Cult Involvement (L. West). Physical Examination (J. McConville & B. McConville). Neurological Examination (J. Bregman). Behavioral Assessment (D. Goldston & K. Kirkhart). Psychodynamic Assessment (D. Berland). Rating Scales (J. Goldman & J. Rodrigue). Psychological Testing (J. Rodrigue & J. Goldman). Structured Interviews (J. Young, et al.). Laboratory Testing (J. Levitt & J. McCracken). Genetic Studies (L. Lotspeich). Speech, Language, and Hearing (C. Baltaxe). Brian Imaging (M. Ernst & L. Hertz-Pannier). Electrophysicological Studies (S. Pliszka). Computers and Assessment (M. Huang & N. Alessi). CONCLUDING THE ASSESSMENT PROCESS. Clincial Formulation (B. Nurcombe). Clinical Decision Making (B. Nurcombe). Intervention Strategy Planning (B. Nurcombe). Interpretive Interview with Children and Adolescents and their Parent(s) (L. Arnold & P. Jensen). Report Preparation (B. Nurcombe). Epilogue: The Paths to the Bright Future of Clinical Child/Adolescent Psychiatry (CAP) (S. Harrison). Indexes.

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Book SynopsisThis volume contains an overview of the history of the field of child psychiatry and examines contemporary issues facing child and adolescent psychiatrists, including the roles that changing family dynamics, multi-culturalism, new technologies, play in children''s development, specialized applications such as forensic psychiatry; and insurance-related, ethical and administrative issues that affect child psychiatrists'' practices.Table of ContentsA BRIEF HISTORY OF CHILD MENTAL HEALTH IN THE UNITED STATES: THE PRECURSORS OF CHILD AND ADOLESCENT PSYCHIATRY (J. Noshpitz). THE IMPACT OF SOCIOCULTURAL EVENTS. THE SEXUAL REVOLUTION (P. Adams). FAMILIES AND YOUNG PEOPLE. The Changing American Family (C. Bergstrand). Mother-Only, Father-Only Families (J. Milner & P. Adams). Feminism and the Rearing of Children (N. Schrepf). OUT-OF-HOME CHILD CARE AND CHILD AND ADOLESCENT DEVELOPMENT. Foster Care (A. Rosenfeld & D. Pilowsky). Clinical Implications of Early Day Care (B. Siegel & A. Rosenfeld). Children and Adolescents in Institutions (L. Kiser). THE CONDUCT-DISORDERED DELINQUENT AND SOCIETY (C. Keith). RELIGION, PARENTING, AND THE MENTAL HELATH OF CHILDREN AND ADOLESCENTS (J. Swanson). AIDS IN CHILDREN AND ADOLESCENTS (E. Sperling). THE ROLE OF TECHNOLOGY IN THE REARING OF CHILDREN. The Impact of Television on Children and Adolescents (G. Henson). The Impact of Computers on Children (C. Holzer & C. Holzer). Space Exploration: Influence on Children and Adolescents (D. Anderson). The Impact of the Nuclear Threat on Children and Adolescents (H. Peck). Children and Reproductive Biotechnology: An Essay into the Unkown (N. Stotland & B. Harwood). WHAT DOES A MULTIETHNIC, PLURALISTIC SOCIETY MEAN FOR YOUTH? (E. Kendrick & P. Ruiz). PREVENTION AND RISK FACTORS. Risk and Protection Factors in Child and Adolescent Psychiatric Disorders (J. McDermott). Demographic and Epidemiologic Studies in Child and Adolescent Psychiatry (C. Holzer & C. Thomas). Parenting and the Development of Children (K. Minde & Regina Minde). Prevention in Child and Adolescent Psychiatry (M. Silverman). CONSULTATION AND CHILD AND ADOLESCENT PSYCHIATRY. The Process of Consultation in Child and Adolescent Psychiatry (L. Brown & G. Fritz). Pediatric Consultation Liaison (M. Jellinek & D. Herzog). School Consultation (I. Berkovitz). Principles of Child Forensic Psychiatry Consultations (D. Schetky). Clinical Consulatation to Mental Health Agencies and Practitioners (D. Gair). EMERGENCY ASSESSMENT AND INTERVENTION. Emergency Assessment (M. Benoit). Emergency Assessment and Treatment of the Child Who Has Witnessed Homicide or Violence (S. Eth). Emergency Assessment and Response to Child Physical and Sexual Abuse (S. Kaplan & E. Pinner). Emergency Assessment and Intervention with a Child or Adolescent Who Has Experienced a Catastrophe (S. Thaggard). Suicide Assessment in Child and Adolescent Emergency Psychiatry (M. Benoit). Violent and Homicidal Children and Adolescents: Emergency Assessment and Intervention (M. Alessi & M. Ghaziuddin). Psychiatric Emergency Evaluation and Inervention with Runaway and Homeless Youngsters (D. Inwood). Emergency Assessment and Treatment of the Anxious Child (D. Fisher & H. Koplewicz). The Emergency Assessment and Response to the Acutely Psychotic Child and Adolescent (J. Sison & L. Flaherty). The Emergency Assessment and Response to the Substance Abusive Child and Adolescent (M. Dell & S. Jaffe). FORENSIC CHILD AND ADOLESCENT PSYCHIATRY. The Rights of Children and Adolescents (J. Milner). The Child and the Law (D. Goyette & P. Schuler). The Child and Adolescent Psychiatrist and the Law (W. Bernet). Ethics in Child Psychiatry (S. Flick & W. Winslade). PROFESSIONAL ISSUES IN CHILD AND ADOLESCNET PSYCHIATRY. Health Insurance and Child/Adolescent Psychiatry (D. Pruitt & L. Kiser). Managed Care as Viewed from the Managed Behavioral Health Care Organization Perspective (I. Shaffer & M. Nelson). The Practice of Child and Adolescent Psychiatry in the Era of Managed Care (Practitioner Perspective (S. Villani). Training in Child and Adolescent Psychiatry (E. Beresin). Administration in Child Psychiatry (D. Pruitt). The Private Practice of Child Psychiatry (I. Fras). Child Psychiatry and Behavioral-Developmental Pediatrics (J. Heston). Research in Child Psychiatry (A. Apter). Indexes.

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Book SynopsisPrinciples of Psychopharmacology for Mental Health Professionals addresses the current "split" model of mental health care, in which physicians provide pharmaco-therapy while non-prescribing practitioners oversee other services such as psychotherapy.Trade Review"…a comprehensive, readily comprehensible resource for non-prescribing, non-physician mental health professionals…" (E-STREAMS, June 2007) "The authors clearly answer the 'what, why, how and when' of psychopharmacology for the nonprescribing clinician." (Doody's Health Services) "...an excellent first edition that pulls together helpful information for nonphysician mental health professionals who wish to learn more about psychiatric illnesses and pharmacologic treatment." (PsycCRITIQUES, December 6, 2006)Table of ContentsPreface. Faculty Disclosure. 1 INTRODUCTION AND OVERVIEW. Additional Reading. 2 BASICS OF PSYCHOPHARMACOLOGY. 2.1 Introduction. 2.3 Pathophysiology: Study of What Goes Wrong. 2.4 Pharmacology. 2.5 Putting It All Together. Additional Reading. 3 MOOD DISORDERS. 3.1 Introduction. 3.2 Major Depressive Disorder. 3.3 Dysthymic Disorder. 3.4 Bipolar Disorders. Additional Reading. 4 SCHIZOPHRENIA. 4.1 Brief Description and Diagnostic Criteria. 4.2 Prevalence and Risk Factors. 4.3 Presentation and Clinical Course. 4.4 Initial Evaluation and Differential Diagnosis. 4.5 History of Treatment. 4.6 Current Approach to Treatment. 4.7 Treatment Resistant Schizophrenia. Additional Reading. 5 ANXIETY DISORDERS. 5.1 Introduction. 5.2 Panic Disorder. 5.3 Generalized Anxiety Disorder. 5.4 Obsessive–Compulsive Disorder. 5.5 Social Anxiety Disorder (Social Phobia). 5.6 Post-Traumatic Stress Disorder. Additional Reading. 6 SUBSTANCE USE DISORDERS. 6.1 Introduction. 6.2 Brief Description and Diagnostic Criteria. 6.3 Prevalence and Risk Factors. 6.4 Presentation and Clinical Course. 6.5 Initial Evaluation and Differential Diagnosis. 6.6 History of Treatment. 6.7 Current Approaches to Treatment. 6.8 Alcohol Use Disorders. 6.9 Cocaine Use Disorders. 6.10 Nicotine Dependence. 6.11 Opiate Use Disorders. Additional Reading. 7 EATING DISORDERS. 7.1 Introduction. 7.2 Anorexia Nervosa. 7.3 Bulimia Nervosa. 7.4 Binge-Eating Disorder. Additional Reading. 8 ATTENTION DEFICIT–HYPERACTIVITY DISORDER. 8.1 Brief Description and Diagnostic Criteria. 8.2 Prevalence and Risk Factors. 8.3 Presentation and Clinical Course. 8.4 Initial Evaluation and Differential Diagnosis. 8.5 History of Pharmacological Treatment. 8.6 Current Approach to Treatment. Additional Reading. 9 SLEEP DISORDERS. 9.1 Introduction. 9.2 Insomnia. 9.3 Narcolepsy. Additional Reading. 10 ALZHEIMER’S DISEASE AND OTHER DEMENTIAS. 10.1 Brief Description and Diagnostic Criteria. 10.2 Prevalence and Risk Factors. 10.3 Presentation and Clinical Course. 10.4 Initial Evaluation and Differential Diagnosis. 10.5 History of Pharmacological Treatment. 10.6 Current Approach to Treatment. Additional Reading. 11 PERSONALITY DISORDERS. 11.1 Introduction. 11.2 Cluster A: Odd and Eccentric Personality Disorders. 11.3 Cluster B: Dramatic and Emotional Personality Disorders. 11.4 Cluster C: Anxious and Fearful Personality Disorders. Additional Reading. 12 TRAUMATIC BRAIN INJURY. 12.1 Introduction. 12.2 Approaches to Treatment. Additional Reading. 13 MANAGING SIDE EFFECTS. 13.1 Introduction. 13.2 Norepinephrine-Related Side Effects. 13.3 Dopamine-Related Side Effects. 13.4 Serotonin-Related Side Effects. 13.5 GABA-Related Side Effects. 13.6 Acetylcholine-Related Side Effects. 13.7 Histamine-Related Side Effects. Index.

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Book SynopsisA comprehensive survey of technological developments in Virtual Reality for use in a variety of medical procedures Medicine and the biological sciences have long relied on visualizations to illustrate the relationship between anatomic structure and biologic function. The new multidimensional imaging modalities are powerful counterparts to traditional forms of observation-surgery, postmortem examination, or extensive mental reconstruction. VR technologies have reached unimagined levels of sophistication and utility, giving physicians and students new avenues for planning and practicing surgery and diagnostics. The two volumes of Information Technologies in Medicine thoroughly explore the use of VR technology in three-dimensional visualization techniques, realistic surgical training prior to patient contact, and actual procedures in rehabilitation and treatment, including telemedicine and telesurgery. Editors Akay and Marsh have brought together all the availablTable of ContentsPREFACE. PART I: TREATMENT. 1. Neuro/Orthopedic Rehabilitation and Disability Solutions Using Virtual Reality Technology (Walter J. Greenleaf). 2. The Use of Virtual Reality Technology in the Treatment of Anxiety Disorders (Brenda K. Wiederhold and Mark D. Wiederhold). 3. Virtual Reality for Health Care (L. Beolchi and G. Riva). 4. Robot-Assisted Microsurgery Development at JPL (Hari Das, Tim Ohm, Curtis Boswell, Rob Steele, and Guillermo Rodriguez). 5. Virtual Reality and the Vestibular System: A Brief Review (Erik Viirre, Zsolt Lorant, Mark Draper, and Thomas A. Furness, III). PART II: TELEMEDICINE AND TELESURGERY. 6. Computer Imagery and Multimedia Techniques for Supporting Telemedicine Diagnoses (Qinglian Guo, Katsunobu Muroi, and Mieko Ohsuga). 7. Implementing a Picture-Achieving and Communication System (PACS) and Teleradiology System: Practical Issues and Considerations (Jihong Wang). 8. From Engineering to Surgery: The Harsh Realities of Virtual Reality (Robert John Stone). 9. Maxillofacial Virtual Surgery from 3-D CT Images (Alessandro Sarti, Roberto Gori, Alberto Bianchi, Claudio Marchetti, and Claudio Lamberti). INDEX.

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Book SynopsisThis comprehensive reference examines the biochemistry of neurotransmission, behavioral pharmacology and clinical aspects of psychiatric problems including depression, manic-depression, and mood disorders. Other chapters address the biological mechanisms and treatment of depression, anxiety, panic, obsessive-compulsive disorder, and addictions.Trade Review"This book is a must for the library of every medical school, basic medical science facility, and psychiatric hospital...useful for students, teachers, and practitioners." (American Journal of Psychiatry, March 2005) "…an ambitious volume, covering a broad swath of important recent research…will undoubtedly appeal to those with research interests in the neuroscientific aspects of psychiatry…" (Journal of the American Medical Association, Vol. 291, No. 17, May 5, 2004) "I would recommend this book as a highly current resource summarizing our knowledge concisely and accurately, pointing to future avenues with great optimism and mastery, and painting an overall very bright view of the team effort that has brought us to our current state." (Journal of Clinical Psychiatry, August 2004)Table of ContentsForeword. Preface. Contributors. Part I: FOUNDATIONAL CONCEPTS. 1. BIOLOGICAL PSYCHIATRY SKETCHED--PAST, PRESENT, AND FUTURE (Jaak Panksepp). 2. IMAGING HUMAN EMOTIONS AND AFFECTIVE FEELINGS: IMPLICATIONS FOR BIOLOGICAL PSYCHIATRY (Mario Liotti and Jaak Panksepp). 3. NEURAL SUBSTRATES OF CONSCIOUSNESS: IMPLICATIONS FOR CLINICAL PSYCHIATRY (Douglas F. Watt and David I. Pincus). 4. STRESS, SLEEP, AND SEXUALITY IN PSYCHIATRIC DISORDERS (Terrence Deak and Jaak Panksepp). 5. PSYCHOBIOLOGY OF PERSONALITY DISORDERS (Brian Knutson and Andreas Heinz). 6. FUNCTIONAL NEUROIMAGING IN PSYCHIATRY (Johannes Tauscher, Nikolas Klein, and Shitij Kapur). Part II: CORE PSYCHIATRIC CHALLENGES. 7. DEPRESSION: A NEUROPSYCHIATRIC PERSPECTIVE (Helen S. Mayberg). 8. TREATMENT OF MOOD DISORDERS (Pedro L. Delgado and Paul Zarkowski). 9. NEUROSCIENCE OF SCHIZOPHRENIA (Christine Pesold, Rosalinda C. Roberts, and Brian Kirkpatrick). 10. PHARMACOLOGICAL TREATMENT OF SCHIZOPHRENIA (Rajiv Tandon and Michael D. Jibson). 11. PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER (Bessel A. van der Kolk). 12. NATURE AND TREATMENT OF PANIC DISORDER (Fredric N. Busch and Barbara L. Milrod). 13. NATURE AND TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (Lisa A. Snider and Susan E. Swedo). 14. BIOLOGICAL BASIS OF CHILDHOOD NEUROPSYCHIATRIC DISORDERS (Bradley S. Peterson and Jaak Panksepp). 15. AGING AND DEMENTIA (Mark T. Wright, A. John McSweeny, and Amy Kieswetter). Part III: FUTURE PROSPECTS. 16. EMERGING NEUROSCIENCE OF FEAR AND ANXIETY: THERAPEUTIC PRACTICE AND CLINICAL IMPLICATIONS (Jaak Panksepp). 17. SOMATIC TREATMENTS IN PSYCHIATRY (Ziad Nahas, Jeffrey P. Lorberbaum, Frank A. Kozel, and Mark S. George). 18. PSYCHOANALYSIS AND PSYCHOPHARMACOLOGY: ART AND SCIENCE OF COMBINING PARADIGMS (Marcia Kaplan). 19. DEPTH PSYCHOLOGICAL CONSEQUENCES OF BRAIN DAMAGE (Oliver H. Turnbull and Mark Solms). 20. SOCIOPHYSIOLOGY AND EVOLUTIONARY ASPECTS OF PSYCHIATRY (Russell Gardner, Jr. and Daniel R. Wilson). 21. FUTURE OF NEUROPEPTIDES IN BIOLOGICAL PSYCHIATRY AND EMOTIONAL PSYCHOPHARMACOLOGY: GOALS AND STRATEGIES (Jaak Panksepp and Jaanus Harro). Appendix A: PHARMACODYNAMICS AND PHARMACOKINETICS (Jaanus Harro). Index.

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Book SynopsisProvides ethical guidelines much needed by the pharmaceutical industry. This book covers ethical issues involved in the testing and use of pharmaceuticals on humans, focusing on the issues surrounding the pharmaceutical industry and not medicine in general.Trade Review"...it will give the uninitiated a feel for the range of ethical isues..." (Mental Health Care, February 2003) "...a good introduction to the ethics surrounding pharmaceuticals..." (Pharmaceutical Physician, March 2003) "...the core question: should you read this book...definitely yes...the book stimulates our thinking and helps the reader to define and outline the many dilemmas in health care..." (Pharm World Sci, Vol. 25, No. 2, 2003)Table of ContentsList of Contributors. Preface. Foreword. 1. The Basis of Ethics (Jon Merrills). 2. Principles of Ethics Focusing on the Patient (Andrew Edgar). 3. Ethical Rationalism Applied to Pharmaceuticals (R.P. Dessing). 4. The Etihcs of the Drug Discovery and Development Process (Roger G. Bolton). 5. Informed Conset: Reconsideration of its Structure and Role in Medicine (Jan Payne). 6. Clinical Trials of Pharmaceuticals: Ethical Aspects (Olivier Chassany, Martin Duracinsky and Isabelle Mahé). 7. Can We Afford the Medicines We Need: An Ethical Dilemma? (Roger Walker). 8. Physician Choice or Patient Choice: Ethical Dilemmas in Science and Politics (Andrew Edgar). 9. The Economics of Drug-Related Morbidity and Mortality: Ethical Considerations (J. Lyle Bootman and Amy J. Grizzle). 10. Holistic Approach in Choice of Pharmaceutical Agents: Ethical Responsibilities (Sam Salek). 11. Ethical Values in the Treatment of Depression and Anxiety (John Lilja, Sam Larsson, David Hamilton and Mia Bauer). 12. Ethical Promotion and Advertising of Medicines: Where Do We Draw the Line? (Ivor Harrison). 13. Ethical Problems of Drug Categorization for Reimbursement (Chris Good). Index.

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Book SynopsisA comprehensive guide that integrates theory, research, and treatment guidelines for using state-of-the-art methods for treating both routine and challenging cases of panic disorder (with or without agoraphobia).Table of ContentsAbout the Author ix Foreword Richard J. McNally xi Preface xiii Part I Theoretical foundations and empirical findings Chapter 1 Panic attacks, panic disorder, and agoraphobia 1 Chapter 2 Comorbidity: panic disorder in context 20 Chapter 3 Cognitive models 37 Chapter 4 Feared sensations: what are their causes? 58 Chapter 5 Meta-analyses of treatment outcome 81 Chapter 6 Treatment outcome: a closer look 111 Chapter 7 Combining psychological treatments with drug therapies 155 Chapter 8 Predicting treatment outcome 178 Part II Clinical protocols and procedures Chapter 9 Assessment 217 Chapter 10 Developing a case formulation 261 Chapter 11 Cognitive-behaviour therapy: an overview 285 Chapter 12 Cognitive interventions 308 Chapter 13 Interoceptive and situational exposure 339 Chapter 14 Adjunctive cognitive-behavioural interventions 366 Chapter 15 Strategies for improving treatment adherence and preventing relapse 388 Chapter 16 Cognitive-behavioural protocols for special populations 401 Chapter 17 Other psychological treatments 427 References 443 Author Index 497 Subject Index 507

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Book SynopsisThis book presents a development of cognitive therapy based on clinical experience and evidence, which offers guidelines for innovative treatments of emotional disorders and conceptual arguments through the concept of metacognition for the future development of cognitive therapy.Trade Review"Helps to develop an understanding of the internal rules and processes that guide thinking, and the factors that lead individuals to become trapped in cycles of negative and distorted thought." (SciTech Book News Vol. 25, No. 2 June 2001) "...I think that all practioners and researchers in cognitive therapy will have something to gain from it... (Psychological Medicine, Vol.32 2002) "...Hats off to Dr Wells!..." (Cognitive Behaviour Therapy, Vol.31, No.3, 20002) "…I learned a lot by reading this book. I am sure that the book has a great deal to offer therapists…" (Cognitive Behaviour Therapy, Vol.31, No.4, 2002) "…I strongly encourage you to read or dip into sections of this book…a researcher’s and clinicians delight…" (British Journal of Clinical Psychology, March 2003)Table of ContentsList of Figures. List of Tables. About the Author. Preface. Acknowledgements. THEORETICAL PERSPECTIVES. Setting the Stage: Metacognition and Cognitive Therapy. The Self-Regulatory Executive Function (S-REF) Model. Metacognition and Emotional Disorder: Evidence for the S-REF Model. Emotional Processing, the S-REF and Trauma Therapy. S-REF, Schema Theory and Interactive Cognitive Subsystems (ICS). CLINICAL APPLICATIONS. Metacognitive Focused Therapy: Basic Constructs. Clinical Assessment of Metacognitions. Modifying Beliefs. New Pathways for Cognitive Restructuring: Attention Modifications (ATT and SAR). Treating Pathological Worry and Generalized Anxiety Disorder. Treating Obsessive-Compulsive Disorder. Concluding Remarks. Appendix I: Metacognitions Questionnaire (MCQ). Appendix II: Scoring Key for the MCQ. Appendix III: Anxious Thoughts Inventory (AnTI). Appendix IV: Scoring Key for the AnTI. Appendix V: Thought Control Questionnaire. Appendix VI: Generalized Anxiety Disorder Scale (GADS). References. Author Index. Subject Index.

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Book SynopsisThe clinical experience of cognitive therapies is adding to the understanding of emotional disorders. Based on clinical experience and evidence, this groundbreaking book represents a development of cognitive therapy through the concept of metacognition. It provides guidelines for innovative treatments of emotional disorders and goes on to offer conceptual arguments for the future development of cognitive therapy. Offers a new concept in cognitive therapy and guidelines for innovative treatment. Clinically grounded, based on a thorough understanding of cognitive therapies in practice. Written by a recognized authority and established author.Trade Review"...Hats off to Dr Wells!..." (Cognitive Behaviour Therapy, Vol.31, No.3, 20002) "…I strongly encourage you to read or dip into sections of this book…a researcher’s and clinicians delight…" (British Journal of Clinical Psychology, March 2003)Table of ContentsList of Figures. List of Tables. About the Author. Preface. Acknowledgements. PART I: THEORETICAL PERSPECTIVES. Setting the Stage: Metacognition and Cognitive Therapy. The Self-Regulatory Executive Function (S-REF) Model. Metacognition and Emotional Disorder: Evidence for the S-REF Model. Emotional Processing, the S-REF and Trauma Therapy. S-REF, Schema Theory and Interactive Cognitive Subsystems (ICS). PART II: CLINICAL APPLICATIONS. Metacognitive Focused Therapy: Basic Constructs. Clinical Assessment of Metacognitions. Modifying Beliefs. New Pathways for Cognitive Restructuring: Attention Modifications (ATT and SAR). Treating Pathological Worry and Generalized Anxiety Disorder. Treating Obsessive-Compulsive Disorder. Concluding Remarks. Appendix I: Metacognitions Questionnaire (MCQ). Appendix II: Scoring Key for the MCQ. Appendix III: Anxious Thoughts Inventory (AnTI). Appendix IV: Scoring Key for the AnTI. Appendix V: Thought Control Questionnaire. Appendix VI: Generalized Anxiety Disorder Scale (GADS). References. Author Index. Subject Index.

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Book SynopsisThis book provides an introduction to Stress Control Method, a psycho-educational, didactic approach to therapy for anxiety and stress which has been developed and used extensively by the author and his colleagues.Trade Review"...I enjoyed reading this well written and clinically useful book..." (Behaviour Research & Therapy, No.40, 2002)Table of ContentsTHE ARGUMENT FOR CHANGE. Treating Anxiety: Delving Beneath the Tip of the Iceberg. Treating Anxiety: The Gulf between Research Findings and Clinical Realities. Treating Anxiety: The Problems in Primary Care. ISSUES IN DEVISING AND SETTING-UP THE GROUP THERAPY. The 'Stress Control' Method. Setting up a Course. Developing Materials for the Course. Preparing for the Course. Running a Course. THE STRESS MANAGEMENT COURSE. Learning about Stress. Treating Somatic Anxiety. Treating Cognitive Anxiety. Treating Behavioural Anxiety. Treating Panic Attacks. Treating Insomnia. Treating Depression. Completing the Jigsaw. EVALUATION AND FUTURE DEVELOPMENTS. Research Evidence. References. Index.

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Book SynopsisThis title offers a unique general introduction to methods andclinical experience of CBT for a wide range of medical conditions,specifically focusing on chronic illness. A concise, accessibleclinical text which assumes basic knowledge of CBT using clinicalexamples and vignettes to illustrate assessment and therapy. ? Includes a range of typical and important medical conditions thatrequire long-term management ? Fills a gap in this growing area of professional work andtrainingTrade Review"…absolutely required reading…I highly recommend this timely book, without reservation…" (Jnl of Cognitive Psychotherapy, Winter 2002)Table of ContentsList of Figures. List of Tables. About the Author. Preface. Acknowledgements. PART I: GENERAL COMPONENTS OF CBT FOR CHRONIC MEDICALPROBLEMS. Introduction. Assessment. Formulation. Treatment Strategies. PART II: THE APPLICATION OF CBT TO SPECIFIC CHRONIC MEDICALPROBLEMS. Cancer. Chronic Pain. Diabetes. Dermatology. Surgical Problems. Cardiac Problems. PART III: PROFESSIONAL PRACTICE AND SERVICE DELIVERY. Professional Issues. Service Provision. PART IV: APPENDICES. Appendix 1: Illness Perception Questionnaire. Appendix 2: Cancer Behavior Inventory (Version 2.0). Appendix 3: Pain Stages of Change Questionnaire. References. Index.

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Book SynopsisThis text serves as a practical guide to the effective diagnosis and treatment of alcohol and drug addictive disorders. It offers clear, step-by-step recommendations on the selection and application of both pharmacological and psychosocial therapies.Table of ContentsPartial table of contents: ASSESSMENT AND DIAGNOSIS OF INTOXICATION AND WITHDRAWAL IN ADDICTIVE DISORDERS. Assessment and Diagnosis in Addictive Disorders (N. Miller, et al.). Intoxication and Withdrawal from Marijuana, LSD, and MDMA (M. Gold & N. Miller). Drug Testing (R. DuPont). PHARMACOLOGICAL TREATMENT OF INTOXICATION AND WITHDRAWAL. Treatment of Opiate Dependence (J. Piszczor & W. Weddington). TREATMENT IN SPECIFIC POPULATIONS. Treatment of Acute Emergencies (S. John). Treatment of Comorbid Surgical Disorders (R. Littrell & G. Hyde). Treatment of Addictive Disorders in Women (L. Miller). Treatment of Gambling, Eating, and Sex Addictions (J. Schneider & R. Irons). TREATMENT PRACTICES. Treatment Management for Acute and Continuing Care (D. Angres & M. Easton). Treatment Efficacy (N. Miller). SPECIAL TOPICS. Forensic and Ethical Issues (A. Daghestani). Index.

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Book SynopsisBuprenorphine: Combatting Drug Abuse with a Unique Opioid Editors: Alan Cowan and John W. Lewis Scientists involved in the study of opioid pharmacology and drug abuse have long included among their goals the development of effective analgesics with reduced potential for abuse and dependence, and the development of effective pharmacological agents for the treatment of opioid abuse and dependence. Buprenorphine appears to have made an important scientific and clinical contribution on both of these fronts. In this timely volume, international experts describe the unusual chemical and biological characteristics which make this agent unique, from the opiate receptor, through animal pharmacology, to clinical uses, culminating in a discussion of the use of buprenorphine as a medication in the treatment of opioid abuse. Buprenorphine holds great promise as a significant addition to the therapeutic menu available to drug abuse therapists. Buprenorphine: CombaTable of ContentsPartial table of contents: CHEMISTRY. Buprenorphine-Medicinal Chemistry (J. Lewis). PRECLINICAL PHARMACOLOGY. Update on the General Pharmacology of Buprenorphine (A. Cowan). ASSAY, METABOLISM, AND PHARMACOKINETICS. Analysis (R. Moore). CLINICAL PHARMACOLOGY AND EVALUATION. Buprenorphine in Psychiatric Disorders (D. Nutt, et al.). STUDIES RELATING TO TREATMENT OF SUBSTANCE ABUSE. Detoxification and Induction Onto Naltrexone (M. Rosen & T. Kosten). PERSPECTIVE. Buprenorphine: What Interests the National Institute on Drug Abuse? (D. Segal & C. Schuster). Index.

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Book SynopsisGenomics and Proteomics Engineering in Medicine and Biology highlights current applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding.Table of ContentsPreface. Contributors. 1. Qualitative Knowledge Models in Functional Genomics and Proteomics (Mor Peleg, Irene S. Gabashvili, and Russ B. Altman). 1.1. Introduction. 1.2. Methods and Tools. 1.3. Modeling Approach and Results. 1.4. Discussion. 1.5. Conclusion. References. 2. Interpreting Microarray Data and Related Applications Using Nonlinear System Identification (Michael Korenberg). 2.1. Introduction. 2.2. Background. 2.3. Parallel Cascade Identification. 2.4. Constructing Class Predictors. 2.5. Prediction Based on Gene Expression Profiling. 2.6. Comparing Different Predictors Over the Same Data Set. 2.7. Concluding Remarks. References. 3. Gene Regulation Bioinformatics of Microarray Data (Gert Thijs, Frank De Smet, Yves Moreau, Kathleen Marchal, and Bart De Moor). 3.1. Introduction. 3.2. Introduction to Transcriptional Regulation. 3.3. Measuring Gene Expression Profiles. 3.4. Preprocessing of Data. 3.5. Clustering of Gene Expression Profiles. 3.6. Cluster Validation. 3.7. Searching for Common Binding Sites of Coregulated Genes. 3.8. Inclusive: Online Integrated Analysis of Microarray Data. 3.9. Further Integrative Steps. 3.10. Conclusion. References. 4. Robust Methods for Microarray Analysis (George S. Davidson, Shawn Martin, Kevin W. Boyack, Brian N. Wylie, Juanita Martinez, Anthony Aragon, Margaret Werner-Washburne, Mo´nica Mosquera-Caro, and Cheryl Willman). 4.1. Introduction. 4.2. Microarray Experiments and Analysis Methods. 4.3. Unsupervised Methods. 4.4. Supervised Methods. 4.5. Conclusion. References. 5. In Silico Radiation Oncology: A Platform for Understanding Cancer Behavior and Optimizing Radiation Therapy Treatment (G. Stamatakos, D. Dionysiou, and N. Uzunoglu). 5.1. Philosophiae Tumoralis Principia Algorithmica: Algorithmic Principles of Simulating Cancer on Computer. 5.2. Brief Literature Review. 5.3. Paradigm of Four-Dimensional Simulation of Tumor Growth and Response to Radiation Therapy In Vivo. 5.4. Discussion. 5.5. Future Trends. References. 6. Genomewide Motif Identification Using a Dictionary Model (Chiara Sabatti and Kenneth Lange). 6.1. Introduction. 6.2. Unified Model. 6.3. Algorithms for Likelihood Evaluation. 6.4. Parameter Estimation via Minorization–Maximization Algorithm. 6.5. Examples. 6.6. Discussion and Conclusion. References. 7. Error Control Codes and the Genome (Elebeoba E. May). 7.1. Error Control and Communication: A Review. 7.3. Reverse Engineering the Genetic Error Control System. 7.4. Applications of Biological Coding Theory. References. 8. Complex Life Science Multidatabase Queries (Zina Ben Miled, Nianhua Li, Yue He, Malika Mahoui, and Omran Bukhres). 8.1. Introduction. 8.2. Architecture. 8.3. Query Execution Plans. 8.4. Related Work. 8.5. Future Trends. References. 9. Computational Analysis of Proteins (Dimitrios I. Fotiadis, Yorgos Goletsis, Christos Lampros, and Costas Papaloukas). 9.1. Introduction: Definitions. 9.2. Databases. 9.3. Sequence Motifs and Domains. 9.4. Sequence Alignment. 9.5. Modeling. 9.6. Classification and Prediction. 9.7. Natural Language Processing. 9.8. Future Trends. References. 10. Computational Analysis of Interactions Between Tumor and Tumor Suppressor Proteins (E. Pirogova, M. Akay, and I. Cosic). 10.1. Introduction. 10.2. Methodology: Resonant Recognition Model. 10.3. Results and Discussions. 10.4. Conclusion. References. Index. About the Editor.

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Book Synopsis* Presents complex material in an easy to understand progression of ideas. * Illustrates principles by example problems taken from physiology and medicine or design problems involving biomedical devices.Table of ContentsPreface xvi Guidance to Instructors xvii Methods for Solving Model Equations xix Acknowledgments xx About the Companion Website xxi Part I Introduction 1 1 Biological Structure and Function 3 1.1 Cell Energy Related to Whole-Body Function 4 1.2 Tissue and Organ Systems 8 1.3 Cell Structure and Energy Metabolism 16 2 Modeling Concepts for Biological Mass Transport 21 2.1 Representation of Biological Media 21 2.2 Mechanisms of Mass Transport 25 2.3 Formulation of Material Balances 30 2.4 Spatially Lumped and Distributed Models 32 References 39 Part II Thermodynamics of Biomedical Processes 41 3 Basics of Equilibrium Thermodynamics 43 3.1 Thermodynamic Systems and States 43 3.2 Heat, Work, and the First Law 44 3.3 Enthalpy and Heat Effects 45 3.4 Entropy and the Second Law 46 3.5 Gibbs Free Energy and Equilibrium 46 3.6 Properties of the Chemical Potential 51 References 53 4 Interfacial and Membrane Equilibria 54 4.1 Equilibrium Criterion 54 4.2 Interfacial Equilibria 56 4.3 Membrane Equilibria 62 4.4 Electrical Double Layer 71 References 75 5 Chemical Reaction Equilibrium 76 5.1 Equilibrium Criterion 76 5.2 Equilibrium Coefficients 78 5.3 Acid Dissociation 80 5.4 Ligand–Receptor Binding 83 5.5 Equilibrium Models of Blood Gas Content 90 References 101 Part III Fundamentals of Rate Processes 103 6 Nonequilibrium Thermodynamics and Transport Rates 105 6.1 Transport Velocities and Fluxes 105 6.2 Stefan–Maxwell Equation 109 6.3 Diffusion of Uncharged Substances 111 6.4 Diffusion of Electrolytes 116 6.5 Transport across Membranes 117 References 123 7 Mechanisms and Models of Diffusion 124 7.1 Transport Rates in Homogeneous Materials 125 7.2 Diffusion Coefficients in Gases 125 7.3 Diffusion Coefficients in Liquids 128 7.4 Transport in Porous Media Models of Tissue 134 7.5 Transport in Suspension Models of Tissue 144 References 151 8 Chemical Reaction Rates 152 8.1 General Kinetic Models 152 8.2 Basis of Reaction Rate Equations 154 8.3 Multi-Step Reactions 158 8.4 Ligand–Receptor Kinetics 161 8.5 Enzyme Kinetics 166 8.6 Urea Cycle as a Reaction Network 173 References 178 Part IV Transport Models in Fluids and Membranes 179 9 Unidirectional Transport 181 9.1 Unidirectional Transport Equations 181 9.2 Steady-State Diffusion 186 9.3 Diffusion with Parallel Convection 191 9.4 Diffusion with Chemical Reaction 194 9.5 Unsteady-State Diffusion 201 References 203 10 Membrane Transport I: Convection and Diffusion Processes 204 10.1 Ordinary Diffusion 204 10.2 Diffusion with Parallel Convection 211 10.3 Cell Membrane Channels 216 References 223 11 Membrane Transport II: Carrier-Mediated Processes 224 11.1 Facilitated Transport of a Single Substance 224 11.2 Cotransport of Two Substrates 227 11.3 Simulation of Tracer Experiments 230 11.4 Primary Active Transport 237 11.5 Electrical Effects on Ion Transport 242 References 244 12 Mass Transfer Coefficients and Chemical Separation Devices 245 12.1 Transport Through a Single Phase 245 12.2 Transport Through Multiple Phases 256 12.3 Design and Performance of Separation Devices 265 References 279 Part V Multidimensional Processes of Molecules and Cells 281 13 Fluid Mechanics I: Basic Concepts 283 13.2 Mechanical Properties and Rheology of Fluids 289 13.3 Model Formulation and Scaling of Fluid Flow 293 13.4 Steady Flow Through A Tube 299 References 306 14 Fluid Mechanics II: Complex Flows 307 14.1 Boundary Layer Flows 307 14.2 Creeping Flow Through a Leaky Tube 319 14.3 Periodic Flow Along a Tube 323 Reference 329 15 Mass Transport I: Basic Concepts and Nonreacting Systems 330 15.1 Three-Dimensional Mass Balances 330 15.2 Special Cases 332 15.3 One-Dimensional Transport Equations 334 15.4 Model Formulation and Scaling of Mass Transport 339 15.5 Diffusion and Convection in Nonreacting Systems 344 References 357 16 Mass Transport II: Chemical Reacting Systems 358 16.1 Single-Phase Processes 358 16.2 Multiphase Processes 368 16.3 Processes with Interfacial Reaction 380 References 387 17 Cell Population Dynamics 388 17.1 Cell Number Balances 388 17.2 Cell Transport and Fate Processes 389 17.3 Single Cell Population Dynamics 394 17.4 Multiple Cell Population Dynamics 399 Reference 409 Part VI Compartmental Modeling 411 18 Compartment Models I: Basic Concepts and Tracer Analysis 413 18.1 Compartmental Modeling Concepts 413 18.2 Multiple-Compartment Models 421 18.3 Nonideal Inputs and Moment Analysis 430 Reference 438 19 Compartment Models II: Analysis of Physiological Systems 439 19.1 Open-Loop Models 439 19.1.1 Multipool Model of Glucose Metabolism 439 19.2 Models with Feedback and Recirculation 452 References 466 Part VII Advanced Biomedical Applications 467 20 Therapies for Tissue and Organ Dysfunction 469 20.1 Dynamics of Urea Clearance in a Patient During Hemodialysis 469 20.2 Hemodialyzer Performance with Varying Filtration 474 20.3 Gas Exchange in an Intravascular Lung Device 480 20.4 Separation of Blood Components by Apheresis 486 20.5 Epidermal Regeneration in Tissue-Engineered Skin 490 References 497 21 Drug Release, Delivery, and Distribution 498 21.1 Drug Release From an Agglomerated Tablet 498 21.2 Drug Release From an Osmotic Pump Device 504 21.3 Intestinal Drug Transport 509 21.4 Drug Distribution in Ablated Tissues 515 21.5 Intracranial Drug Delivery and Distribution 520 21.6 Whole-Body Methotrexate Distribution 526 References 534 22 Diagnostics and Sensing 535 22.1 Chemical Monitoring of Tissue by Microdialysis 535 22.2 Dual-Electrode Measurement of Blood Flow and Oxygen 541 22.3 Detection of Ethanol in Blood from Exhaled Gas 546 22.4 Oxygen Uptake and Utilization in Exercising Muscle 552 22.5 Tracer Analysis with Pet Imaging 562 22.6 Cancer Cell Migration with Cell–Cell Interaction 569 References 576 Appendix A Units and Property Data 577 A.1 American National Standard for SI Units 577 A.2 Definitions of Concentration 579 A.3 Thermodynamic Properties 580 A.4 Transport Properties 583 References 586 Appendix B Representing Transport Processes in Complex Systems 587 B.1 Vector and Tensor Operations 587 B.2 Nonequilibrium Thermodynamics 592 B.3 Spatially Averaged Balances for Heterogeneous Tissue 596 B.4 Tables for Fluid Motion in Common Coordinate Systems 602 References 604 Appendix C Mathematical Methods 605 C.1 Dimensionless Forms and Scaling 605 C.2 Inversion of Square Matrices 608 C.3 Initial-value Problems 609 C.4 Laplace Transforms 613 C.5 Alternative Representation of a Point Source 614 C.6 Similarity Transform of a Partial Differential Equation 615 Nomenclature 619 Index 624

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Book SynopsisA complete overview of electromyography with contributions from pacesetters in the field In recent years, insights from the field of engineering have illuminated the vast potential of electromyography (EMG) in biomedical technology. Featuring contributions from key innovators working in the field today, Electromyography reveals the broad applications of EMG data in areas as diverse as neurology, ergonomics, exercise physiology, rehabilitation, movement analysis, biofeedback, and myoelectric control of prosthesis. Bridging the gap between engineering and physiology, this pioneering volume explains the essential concepts needed to detect, understand, process, and interpret EMG signals using non-invasive electrodes. Electromyography shows how engineering tools such as models and signal processing methods can greatly augment the insight provided by surface EMG signals. Topics covered include: Basic physiology and biophysics of EMG generation Trade Review"...the best single reference book currently available in the field…" (Annals of Biomedical Engineering, November 2005) "...the authors successfully reported...the unknown aspects of electromyography, in particular the non-invasive approaches to the neurophysiological monitoring of the central nervous system." (Doody's Health Services) Table of ContentsIntroduction. Contributors. 1 BASIC PHYSIOLOGY AND BIOPHYSICS OF EMG SIGNAL GENERATION (T. Moritani, D. Stegeman, R. Merletti). 1.1 Introduction. 1.2 Basic Physiology of Motor Control and Muscle Contraction. 1.3 Basic Electrophysiology of the Muscle Cell Membrane. References. 2 NEEDLE AND WIRE DETECTION TECHNIQUES (J. V. Trontelj, J. Jabre, M. Mihelin). 2.1 Anatomical and Physiological Background of Intramuscular Recording. 2.2 Recording Characteristics of Needle Electrodes. 2.3 Conventional Needle EMG. 2.4 Special Needle Recording Techniques. 2.5 Physical Characteristics of Needle EMG Signals. 2.6 Recording Equipment. References. 3 DECOMPOSITION OF INTRAMUSCULAR EMG SIGNALS (D. W. Stashuk, D. Farina, K. Søgaard). 3.1 Introduction. 3.2 Basic Steps for EMG Signal Decomposition. 3.3 Evaluation of Performance of EMG Signal Decomposition Algorithms. 3.4 Applications of Results of the Decomposition of an Intramuscular EMG Signal. 3.5 Conclusions. References. 4 BIOPHYSICS OF THE GENERATION OF EMG SIGNALS (D. Farina, R. Merletti, D. F. Stegeman). 4.1 Introduction. 4.2 EMG Signal Generation. 4.3 Crosstalk. 4.4 Relationships between Surface EMG Features and Developed Force. 4.5 Conclusions. References. 5 DETECTION AND CONDITIONING OF THE SURFACE EMG SIGNAL (R. Merletti, H. Hermens). 5.1 Introduction. 5.2 Electrodes: Their Transfer Function. 5.3 Electrodes: Their Impedance, Noise, and dc Voltages. 5.4 Electrode Configuration, Distance, Location. 5.5 EMG Front-End Amplifiers. 5.6 EMG Filters: Specifications. 5.7 Sampling and A/D Conversion. 5.8 European Recommendations on Electrodes and Electrode Locations. References. 6 SINGLE-CHANNEL TECHNIQUES FOR INFORMATION EXTRACTION FROM THE SURFACE EMG SIGNAL (E. A. Clancy, D. Farina, G. Filligoi). 6.1 Introduction. 6.2 Spectral Estimation of Deterministic Signals and Stochastic Processes. 6.3 Basic Surface EMG Signal Models. 6.4 Surface EMG Amplitude Estimation. 6.5 Extraction of Information in Frequency Domain from Surface EMG Signals. 6.6 Joint Analysis of EMG Spectrum and Amplitude (JASA). 6.7 Recurrence Quantification Analysis of Surface EMG Signals. 6.8 Conclusions. References. 7 MULTI-CHANNEL TECHNIQUES FOR INFORMATION EXTRACTION FROM THE SURFACE EMG (D. Farina, R. Merletti, C. Disselhorst-Klug). 7.1 Introduction. 7.2 Spatial Filtering. 7.3 Spatial Sampling. 7.4 Estimation of Muscle-Fiber Conduction Velocity. 7.5 Conclusions. References. 8 EMG MODELING AND SIMULATION (D. F. Stegeman, R. Merletti, H. J. Hermens). 8.1 Introduction. 8.2 Phenomenological Models of EMG. 8.3 Elements of Structure-Based SEMG Models. 8.4 Basic Assumptions. 8.5 Elementary Sources of Bioelectric Muscle Activity. 8.6 Fiber Membrane Activity Profiles, Their Generation, Propagation, and Extinction. 8.7 Structure of the Motor Unit. 8.8 Volume Conduction. 8.9 Modeling EMG Detection Systems. 8.10 Modeling Motor Unit Recruitment and Firing Behavior. 8.11 Inverse Modeling. 8.12 Modeling of Muscle Fatigue. 8.13 Other Applications of Modeling. 8.14 Conclusions. References. 9 MYOELECTRIC MANIFESTATIONS OF MUSCLE FATIGUE (R. Merletti, A. Rainoldi, D. Farina). 9.1 Introduction. 9.2 Definitions and Sites of Neuromuscular Fatigue. 9.3 Assessment of Muscle Fatigue. 9.4 How Fatigue Is Reflected in Surface EMG Variables. 9.5 Myoelectric Manifestations of Muscle Fatigue in Isometric Voluntary Contractions. 9.6 Fiber Typing and Myoelectric Manifestations of Muscle Fatigue. 9.7 Factors Affecting Surface EMG Variable. 9.8 Repeatability of Estimates of EMG Variables and Fatigue Indexes. 9.9 Conclusions. References. 10 ADVANCED SIGNAL PROCESSING TECHNIQUES (D. Zazula, S. Karlsson, C. Doncarli). 10.1 Introduction. 10.2 Theoretical Background. 10.3 Decomposition of EMG Signals. 10.4 Applications to Monitoring Myoelectric Manifestations of Muscle Fatigue. 10.5 Conclusions. Acknowledgment. References. 11 SURFACE MECHANOMYOGRAM (C. Orizio). 11.1 The Mechanomyogram (MMG): General Aspects during Stimulated and Voluntary Contraction. 11.2 Detection Techniques and Sensors Comparison. 11.3 Comparison between Different Detectors. 11.4 Simulation. 11.5 MMG Versus Force: Joint and Adjunct Information Content. 11.6 MMG Versus EMG: Joint and Adjunct Information Content. 11.7 Area of Application. References. 12 SURFACE EMG APPLICATIONS IN NEUROLOGY (M. J. Zwarts, D. F. Stegeman, J. G. van Dijk). 12.1 Introduction. 12.2 Central Nervous System Disorders and SEMG. 12.3 Compound Muscle Action Potential and Motor Nerve Conduction. 12.4 CMAP Generation. 12.5 Clinical Applications. 12.6 Pathological Fatigue. 12.7 New Avenues: High-Density Multichannel Recording. 12.8 Conclusion. References. 13 APPLICATIONS IN ERGONOMICS (G. M. Hägg, B. Melin, R. Kadefors). 13.1 Historic Perspective. 13.2 Basic Workload Concepts in Ergonomics. 13.3 Basic Surface EMG Signal Processing. 13.4 Load Estimation and SEMG Normalization and Calibration. 13.5 Amplitude Data Reduction over Time. 13.6 Electromyographic Signal Alterations Indicating Muscle Fatigue in Ergonomics. 13.7 SEMG Biofeedback in Ergonomics. 13.8 Surface EMG and Musculoskeletal Disorders. 13.9 Psychological Effects on EMG. References. 14 APPLICATIONS IN EXERCISE PHYSIOLOGY (F. Felici). 14.1 Introduction. 14.2 A Few “Tips and Tricks”. 14.3 Time and Frequency Domain Analysis of sEMG: What Are We Looking For? 14.4 Application of sEMG to the Study of Exercise. 14.5 Strength and Power Training. 14.6 Muscle Damage Studied by Means of sEMG. References. 15 APPLICATIONS IN MOVEMENT AND GAIT ANALYSIS (C. Frigo, R. Shiavi). 15.1 Relevance of Electromyography in Kinesiology. 15.2 Typical Acquisition Settings. 15.3 Study of Motor Control Strategies. 15.4 Investigation on the Mechanical Effect of Muscle Contraction. 15.5 Gait Analysis. 15.6 Identification of Pathophysiologic Factors. 15.7 Workload Assessment in Occupational Biomechanics. 15.8 Biofeedback. 15.9 The Linear Envelope. 15.10 Information Enhancement through Multifactorial Analysis. References. 16 APPLICATIONS IN REHABILITATION MEDICINE AND RELATED FIELDS (A. Rainoldi, R. Casale, P. Hodges, G. Jull). 16.1 Introduction. 16.2 Electromyography as a Tool in Back and Neck Pain. 16.3 EMG of the Pelvic Floor: A New Challenge in Neurological Rehabilitation. 16.4 Age-Related Effects on EMG Assessment of Muscle Physiology. 16.5 Surface EMG and Hypobaric Hipoxia. 16.6 Microgravity Effects on Neuromuscular System. References. 17 BIOFEEDBACK APPLICATIONS (J. R. Cram). 17.1 Introduction. 17.2 Biofeedback Application to Impairment Syndromes. 17.3 SEMG Biofeedback Techniques. 17.4 Summary. References. 18 CONTROL OF POWERED UPPER LIMB PROSTHESES (P. A. Parker, K. B. Englehart, B. S. Hudgins). 18.1 Introduction. 18.2 Myoelectric Signal as a Control Input. 18.3 Conventional Myoelectric Control. 18.4 Emerging MEC Strategies. 18.5 Summary. References. Index.

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Book SynopsisCancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.Trade Review“In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.” (ChemMedChem, 1 July 2013)Table of ContentsContributors. Preface. SECTION I: EPIGENETICS AND CELL CYCLE. 1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso). SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION. 2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano). 3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn). 4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli). SECTION III: EPIGENETICS AND GENE TRANSCRIPTION. 5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini-Kerth). 6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano). SECTION IV: EPIGENETICS AND CANCER. 7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell). 8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa). 9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota). 10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio). SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY. 11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano). 12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr). 13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano). 14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio). Index.

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