Description
Book SynopsisThe Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.
Table of ContentsList of Contributors xi
Introduction xvii
Sharon Rounds and Norbert Voelkel
Section I: Normal Pulmonary Endothelium. Structure, Function, Cell Biology 1
1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 3
Margaret A. Schwarz and Ondine B. Cleaver
2: Anatomy of the Pulmonary Endothelium 25
Radu V. Stan
3: Cadherins and Connexins in Pulmonary Endothelial Function 33
Kaushik Parthasarathi and Sadiqa K. Quadri
4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 51
Katie L. Grinnell and Elizabeth O. Harrington
5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 73
Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta
6: Pulmonary Endothelium and Nitric Oxide 89
Yunchao Su and Edward R. Block
7: Pulmonary Endothelial Cell Surface Metabolic Functions 105
Usamah S. Kayyali and Barry L. Fanburg
8: Cell Biology of Lung Endothelial Permeability 113
Guochang Hu and Richard D. Minshall
9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 129
Donna L. Cioffi, Songwei Wu and Troy Stevens
10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 143
Rosana Souza Rodrigues and Guy A. Zimmerman
11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 167
Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid
12: Pulmonary Endothelium and Vasomotor Control 185
Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta
13: Pulmonary Endothelial Progenitor Cells 203
Bernard Thébaud and Mervin C. Yoder
14: Bronchial Vasculature: The Other Pulmonary Circulation 217
Elizabeth Wagner
15: Mapping Protein Expression on Pulmonary Vascular Endothelium 229
Kerri A. Massey and Jan E. Schnitzer
Section II: Mechanisms and Consequences of Pulmonary Endothelial Cell Injury 241
16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 243
Qing Lu and Sharon Rounds
17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 261
Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher
18: Hypoxia and the Pulmonary Endothelium 287
Matthew Jankowich, Gaurav Choudhary and Sharon Rounds
19: Viral Infection and Pulmonary Endothelial Cells 303
Norbert F. Voelkel
20: Effects of Pressure and Flow on the Pulmonary Endothelium 309
Wolfgang M. Kuebler
21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 337
Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia
22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 355
Vladimir R. Muzykantov
Section III: Pulmonary Endothelium In Disease 379
23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 381
Yuansheng Gao and J. Usha Raj
24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 399
Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia
25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 417
Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel
26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease 437
Norbert F. Voelkel and Ramesh Natarajan
27: Pulmonary Endothelium and Pulmonary Hypertension 449
Rubin M. Tuder and Serpil C. Erzurum
28: Collagen Vascular Diseases and Pulmonary Endothelium 461
Pradeep R. Rai and Carlyne D. Cool
29: Pulmonary Endothelium in Thromboembolism 471
Irene M. Lang
30: Pulmonary Endothelium and Malignancies 485
Abu-Bakr Al-Mehdi
Epilogue
Norbert F. Voelkel
Index 495
