Medical research Books

Book Synopsis'The author gives an excellent overview and explores how children have been seen as objects and subjects in research as well as increasingly as participants and more recently still as researchers.'- International Journal of Research and Method in Education'This book is especially beneficial in terms of its breadth of discussion on the legal, ethical and moral issues of conducting research with children and young people alongside the key methodological challenges that students and practitioners are faced when conducting this type of research' - Research Policy and PlanningDoing Research with Children and Young People introduces researchers to the key considerations involved in working with children and young people. The book highlights issues which arise at different stages in the process and which all researchers need to take account of as they plan and carry out a study. These include: ethicalTable of ContentsDoing Research with Children and Young People - Vicky Lewis An Introduction PART ONE: SETTING THE CONTEXT Situating Empirical Research - Sandy Fraser Images of Childhood - Mary Kellett, Chris Robinson and Rachel Burr The Legal Context - Judith Masson Paradigms and Philosophy - Sandy Fraser and Chris Robinson PART TWO: RESEARCH RELATIONS Power - Chris Robinson and Mary Kellett Ethics - Priscilla Alderson Involving Children and Young People as Researchers - Adele Jones Gender - Rob Pattman and Mary Jane Kehily PART THREE: DIVERSITY Early Childhood - Ann Langston et al Middle Childhood - Mary Kellett and Sharon Ding Young People - Alan France Disability - Vicky Lewis and Mary Kellett Participatory Action Research in the Majority World - Olga Nieuwenhuys Race and Ethnicity - Mani Maniam et al PART FOUR: RELEVANCE, EVALUATION AND DISSEMINATION Health and Social Care - Helen Roberts Education - Ann Edwards Childhood Studies - Jim McKechnie and Sandy Hobbs

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Book SynopsisEconomists advocate regulation and tailored incentives to stimulate improvement activities. Such activities should be adopted if their benefits outweigh their costs. This title is also available as Open Access on Cambridge Core.Table of Contents1. Introduction; 2. The Economic Approach to Healthcare Improvement; 3. Stimulating Healthcare Improvement; 4. Evaluating Healthcare Improvement Activities; 5. Critiques of the Approach; 6. Further Research; 7. Conclusions; 8. Further Reading; Contributors; References.

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Book SynopsisMicrosystems are the building blocks of the healthcare system. They are the small functional frontline units that provide most healthcare to most people, be it a clinic or a ward. The microsystem improvement approach engages teams at the frontline of care with patients and families in a structured process to improve the quality of care and outcomes. This Element offers an overview of the theory of the microsystems, mesosystems, and team coaching improvement approaches, using case studies to demonstrate how the approaches have been used in practice. A critique of the emerging evidence base and the strengths and limitations of the approach is given. This title is also available as open access on Cambridge Core.

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Book SynopsisThe use of medicinal plants in herbal and modern medicine has gained popularity over the last few decades due to consumers taking more natural approaches to medicine. Aquatic medicinal plants are rich in bioactive compounds and demonstrate various commercial, nutraceutical, and biological applications. Aquatic Medicinal Plants offers the reader a wealth of information on uses of bioactive components of these plants, along with crucial references, and explains their traditional uses, phytochemistry, and pharmacological properties.Features Provides information on aquatic and semiaquatic medicinal plants and their uses globally. Discusses phytochemical components with the known active constituents and their pharmaceutical applications. This volume in the Exploring Medicinal Plants series is appropriate for scientists, experts, and consultants associated with the exploration of aquatic medicinal plant usage.  This book is an essenTable of ContentsMedicinal Importance of Nelumbo nucifera. Traditional Uses, Important Phytochemical, and Therapeutic Profile of Persicaria hydropiper. Ethnobotanical, Phytochemistry, and Pharmacological Activity of Marsilea minuta. Traditional Uses, Phytochemistry, and Pharmacological Properties of Hedychium coronarium. Pharmacognostical Phytochemical, and Ethnomedicinal Properties of Enhydra fluctuans. Medicinal Uses and Pharmacological Properties of Acorus calamus. Medicinal properties of Rotula aquatic. Traditional Uses and Pharmacological Profile of Sphaeranthus indicus. Phytochemistry and Medicinal Uses of Pistia stratiotes. Biological Activity and Medicinal Uses of Arundo donax. Sagittaria sagittifolia. Phytochemistry and Pharmaceutical Application of Laurencia obtuse: A Red Seaweed. Phytochemical and Therapeutic Properties of Didemnum genus. Brown Algae (Phaeophyta) Source of Different Phytochemical and their Medicinal Application. Phytochemistry and Bioactivity of Green Algae (Chlorophyta). Chemical Composition and Biological Activity of Red Algae (Rhodophyta).

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisThis second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible,Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- SpeciTable of Contents1. Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease David A. Dunn and Carl A. Pinkert 2. Mitochondrial Transplantation for Ischemia Reperfusion Injury Ilias P. Doulamis and James D. McCully 3. Quantitatively Controlled Intercellular Mitochondrial Transfer by Cell Fusion-Based Method Using a Microfluidic Device Ken-Ichi Wada, Kazuo Hosokawa, Yoshihiro Ito, and Mizuo Maeda 4. Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable Into Human Mitochondria Ilya Dovydenko, Mariya Meschaninova, Anne-Marie Heckel, Ivan Tarassov, Alya Venyaminova, and Nina Entelis 5. Drug Discovery Assay to Identify Modulators of the Mitochondrial Ca2+ Uniporter Daniela M. Arduino, Valerie Goh, Dejana Mokranjac, and Fabiana Perocchi 6. Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller 7. Electron Attachment to Isolated Molecules as a Probe To Understand Mitochondrial Reductive Processes Stanislav A. Pshenichnyuk and Alberto Modelli 8. Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation Matthias Hecker, Natascha Sommer, and Konstantin Mayer 9. Assessment of the Effects of Drugs on Mitochondrial Respiration Jana Hroudová and Zdeněk Fišar 10. The Ndufs4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging Anthony S. Grillo, Alessandro Bitto, and Matt Kaeberlein 11. Suborganellar Localisation of Mitochondrial Proteins and Transcripts in Human Cells Anna Smirnova, Ludovic Richert, Alexandre Smirnov, Yves Mély, and Ivan Tarassov 12. In vivo Assessment of Mitochondrial Oxygen Consumption Floor A. Harms and Egbert G. Mik 13. Update of Mitochondrial Network Analysis by Imaging: Proof of Technique in Schizophrenia Yekaterina Yatchenko and Dorit Ben-Shachar 14. Heterologous Inferential Analysis (HIA) and other Emerging Concepts In Understanding Mitochondrial Variation in Pathogenesis: There is no More Low Hanging Fruit Antón Vila-Sanjurjo, Paul M. Smith, and Joanna L. Elson 15. Accurate Measurement of Cellular and Cell-Free Circulating Mitochondrial DNA Content from Human Blood Samples Using Real Time Quantitative PCR Hannah Rosa and Afshan Malik 16. Measurement of Mitochondrial Respiration in Platelets Zdeněk Fišar and Jana Hroudová 17. Isolation and Electron Microscopic Analysis of Liver Cancer Cell Mitochondria Yaschar Kabiri, Carola Eberhagen, Sabine Schmitt, Percy A. Knolle, and Hans Zischka 18. Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells Madhavee Thumiah-Mootoo, Tina Podinic, and Mireille Khacho 19. Single Cell Approaches for Studying the Role of Mitochondrial DNA in Neurodegenerative Disease Laura J. Bailey, Joanna L. Elson, and Ilse S. Pienaar 20. A New Method for Sequencing the Mitochondrial Genome by Using Long Read Technology Sophie Dhorne-Pollet, Nicolas Pollet, and Eric Barrey 21. Mitochondrial DNA as a Sensitive Biomarker of UV-induced Cellular Damage in Human Skin Amy Bowman and Mark A. Birch-Machin 22. Isolation of Mitochondria-associated ER Membranes (MAMs), Synaptic MAMs and Glycosphingolipid Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells Ida Annunziata, Jason Andrew Weesner, and Alessandra d’Azzo 23. Mitochondrial Diagnostics: A Discovery-Based Biochemical Platform for Phenotyping Human Peripheral Blood Cell Mitochondria Margaret A. M. Nelson and Kelsey H. Fisher-Wellman 24. Bioenergetic Profiling Of Human Pluripotent Stem Cells Gizem Inak-Girrbach, Marie-Thérèse Henke, and Alessandro Prigione 25. Integrative Methods for Studying Cardiac Energetics Philippe Diolez, Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Laurent Arsac, Pierre Jais, Michel Haissaguerre, and Pierre dos Santos 26. Isolation of Mitochondria from Retinal Pigment Epithelial Cell Cultures and an Application Of High Resolution Respirometric Assay (XFe96 Seahorse assay) Masaaki Ishii, Gyda Beeson, Craig Beeson, and Bärbel Rohrer 27. The Isolation and Deep Sequencing of Mitochondrial DNA Alexander G. Bury, Fiona M. Robertson, Angela Pyle, Brendan A. I. Payne, and Gavin Hudson 28. Ultrastructure of the Mitochondria-Associated Membranes in Human Tumor Specimens Gabriel Arismendi-Morillo

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Book SynopsisA practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective.Table of ContentsPreface xiii List of Abbreviations xxi About the Companion Website xxv 1 Introduction to Evidence Synthesis 1 1.1 Introduction 1 1.2 Why Indirect Comparisons and Network Meta-Analysis? 2 1.3 Some Simple Methods 4 1.4 An Example of a Network Meta-Analysis 6 1.5 Assumptions Made by Indirect Comparisons and Network Meta-Analysis 9 1.6 Which Trials to Include in a Network 12 1.6.1 The Need for a Unique Set of Trials 12 1.7 The Definition of Treatments and Outcomes: Network Connectivity 14 1.7.1 Lumping and Splitting 14 1.7.2 Relationships Between Multiple Outcomes 15 1.7.3 How Large Should a Network Be? 15 1.8 Summary 16 1.9 Exercises 16 2 The Core Model 19 2.1 Bayesian Meta-Analysis 19 2.2 Development of the Core Models 20 2.2.1 Worked Example: Meta-Analysis of Binomial Data 21 2.2.1.1 Model Specification: Two Treatments 21 2.2.1.2 WinBUGS Implementation: Two Treatments 25 2.2.2 Extension to Indirect Comparisons and Network Meta-Analysis 32 2.2.2.1 Incorporating Multi-Arm Trials 35 2.2.3 Worked Example: Network Meta-Analysis 36 2.2.3.1 WinBUGS Implementation 37 2.3 Technical Issues in Network Meta-Analysis 50 2.3.1 Choice of Reference Treatment 50 2.3.2 Choice of Prior Distributions 51 2.3.3 Choice of Scale 53 2.3.4 Connected Networks 54 2.4 Advantages of a Bayesian Approach 55 2.5 Summary of Key Points and Further Reading 56 2.6 Exercises 57 3 Model Fit, Model Comparison and Outlier Detection 59 3.1 Introduction 59 3.2 Assessing Model Fit 60 3.2.1 Deviance 60 3.2.2 Residual Deviance 61 3.2.3 Zero Counts* 62 3.2.4 Worked Example: Full Thrombolytic Treatments Network 62 3.2.4.1 Posterior Mean Deviance, D̅model 62 3.2.4.2 Posterior Mean Residual Deviance, D̅res 64 3.3 Model Comparison 66 3.3.1 Effective Number of Parameters, pD 68 3.3.2 Deviance Information Criterion (DIC) 69 3.3.2.1 *Leverage Plots 70 3.3.3 Worked Example: Full Thrombolytic Treatments Network 70 3.4 Outlier Detection in Network Meta-Analysis 75 3.4.1 Outlier Detection in Pairwise Meta-Analysis 75 3.4.2 Predictive Cross-Validation for Network Meta-Analysis 79 3.4.3 Note on Multi-Arm Trials 85 3.4.4 WinBUGS Code: Predictive Cross-Validation for Network Meta-Analysis 86 3.5 Summary and Further Reading 89 3.6 Exercises 90 4 Generalised Linear Models 93 4.1 A Unified Framework for Evidence Synthesis 93 4.2 The Generic Network Meta-Analysis Models 94 4.3 Univariate Arm-Based Likelihoods 99 4.3.1 Rate Data: Poisson Likelihood and Log Link 99 4.3.1.1 WinBUGS Implementation 100 4.3.1.2 Example: Dietary Fat 101 4.3.1.3 Results: Dietary Fat 104 4.3.2 Rate Data: Binomial Likelihood and Cloglog Link 105 4.3.2.1 WinBUGS Implementation 107 4.3.2.2 Example: Diabetes 109 4.3.2.3 Results: Diabetes 112 4.3.3 Continuous Data: Normal Likelihood and Identity Link 114 4.3.3.1 Before/After Studies: Change from Baseline Measures 115 4.3.3.2 Standardised Mean Differences 115 4.3.3.3 WinBUGS Implementation 116 4.3.3.4 Example: Parkinson’s 117 4.3.3.5 Results: Parkinson’s 119 4.4 Contrast-Based Likelihoods 120 4.4.1 Continuous Data: Treatment Differences 121 4.4.1.1 Multi-Arm Trials with Treatment Differences (Trial-Based Summaries) 122 4.4.1.2 *WinBUGS Implementation 123 4.4.1.3 Example: Parkinson’s (Treatment Differences as Data) 125 4.4.1.4 Results: Parkinson’s (Treatment Differences as Data) 127 4.5 *Multinomial Likelihoods 127 4.5.1 Ordered Categorical Data: Multinomial Likelihood and Probit Link 128 4.5.1.1 WinBUGS Implementation 132 4.5.1.2 Example: Psoriasis 133 4.5.1.3 Results: Psoriasis 137 4.5.2 Competing Risks: Multinomial Likelihood and Log Link 138 4.5.2.1 WinBUGS Implementation 140 4.5.2.2 Example: Schizophrenia 141 4.5.2.3 Results: Schizophrenia 143 4.6 *Shared Parameter Models 146 4.6.1 Example: Parkinson’s (Mixed Treatment Difference and Arm-Level Data) 147 4.6.2 Results: Parkinson’s (Mixed Treatment Difference and Arm-Level Data) 148 4.7 Choice of Prior Distributions 149 4.8 Zero Cells 149 4.9 Summary of Key Points and Further Reading 150 4.10 Exercises 151 5 Network Meta-Analysis Within Cost-Effectiveness Analysis 155 5.1 Introduction 155 5.2 Sources of Evidence for Relative Treatment Effects and the Baseline Model 156 5.3 The Baseline Model 158 5.3.1 Estimating the Baseline Model in WinBUGS 158 5.3.2 Alternative Computation Methods for the Baseline Model 162 5.3.3 *Arm-Based Meta-Analytic Models 162 5.3.4 Baseline Models with Covariates 164 5.3.4.1 Using Aggregate Data 164 5.3.4.2 Risk Equations for the Baseline Model Basedon Individual Patient Data 165 5.4 The Natural History Model 165 5.5 Model Validation and Calibration Through Multi-Parameter Synthesis 167 5.6 Generating the Outputs Required for Cost-Effectiveness Analysis 169 5.6.1 Generating a CEA 169 5.6.2 Heterogeneity in the Context of Decision-Making 170 5.7 Strategies to Implement Cost-Effectiveness Analyses 173 5.7.1 Bayesian Posterior Simulation: One-Stage Approach 174 5.7.2 Bayesian Posterior Simulation: Two-Stage Approach 174 5.7.3 Multiple Software Platforms and Automation of Network Meta-Analysis 175 5.8 Summary and Further Reading 177 5.9 Exercises 178 6 Adverse Events and Other Sparse Outcome Data 179 6.1 Introduction 179 6.2 Challenges Regarding the Analysis of Sparse Data in Pairwise and Network Meta-Analysis 180 6.2.1 Network Structure and Connectivity 182 6.2.2 Assessing Convergence and Model Fit 182 6.3 Strategies to Improve the Robustness of Estimation of Effects from Sparse Data in Network Meta-Analysis 183 6.3.1 Specifying Informative Prior Distributions for Response in Trial Reference Groups 183 6.3.2 Specifying an Informative Prior Distribution for the Between Study Variance Parameters 184 6.3.3 Specifying Reference Group Responses as Exchangeable with Random Effects 184 6.3.4 Situational Modelling Extensions 185 6.3.5 Specification of Informative Prior Distributions Versus Use of Continuity Corrections 186 6.4 Summary and Further Reading 186 6.5 Exercises 187 7 Checking for Inconsistency 189 7.1 Introduction 189 7.2 Network Structure 190 7.2.1 Inconsistency Degrees of Freedom 191 7.2.2 Defining Inconsistency in the Presence of Multi-Arm Trials 192 7.3 Loop Specific Tests for Inconsistency 195 7.3.1 Networks with Independent Tests for Inconsistency 195 7.3.1.1 Bucher Method for Single Loops of Evidence 195 7.3.1.2 Example: HIV 196 7.3.1.3 Extension of Bucher Method to Networks with Multiple Loops: Enuresis Example 197 7.3.1.4 Obtaining the ‘Direct’ Estimates of Inconsistency 199 7.3.2 Methods for General Networks 200 7.3.2.1 Repeat Application of the Bucher Method 201 7.3.2.2 A Back-Calculation Method 202 7.3.2.3 *Variance Measures of Inconsistency 202 7.3.2.4 *Node-Splitting 203 7.4 A Global Test for Loop Inconsistency 205 7.4.1 Inconsistency Model with Unrelated Mean Relative Effects 206 7.4.2 Example: Full Thrombolytic Treatments Network 210 7.4.2.1 Adjusted Standard Errors for Multi-Arm Trials 214 7.4.3 Example: Parkinson’s 215 7.4.4 Example: Diabetes 218 7.5 Response to Inconsistency 219 7.6 The Relationship between Heterogeneity and Inconsistency 221 7.7 Summary and Further Reading 223 7.8 Exercises 225 8 Meta-Regression for Relative Treatment Effects 227 8.1 Introduction 227 8.2 Basic Concepts 229 8.2.1 Types of Covariate 229 8.3 Heterogeneity, Meta-Regression and Predictive Distributions 232 8.3.1 Worked Example: BCG Vaccine 233 8.3.2 Implications of Heterogeneity in Decision Making 236 8.4 Meta-Regression Models for Network Meta-Analysis 238 8.4.1 Baseline Risk 241 8.4.2 WinBUGS Implementation 242 8.4.3 Meta-Regression with a Continuous Covariate 245 8.4.3.1 BCG Vaccine Example: Pairwise Meta-Regression with a Continuous Covariate 245 8.4.3.2 Certolizumab Example: Network Meta-Regression with Continuous Covariate 247 8.4.3.3 Certolizumab Example: Network Meta-Regression on Baseline Risk 252 8.4.4 Subgroup Effects 255 8.4.4.1 Statins Example: Pairwise Meta-Analysis with Subgroups 256 8.5 Individual Patient Data in Meta-Regression 257 8.6 Models with Treatment-Level Covariates 261 8.6.1 Accounting for Dose 261 8.6.2 Class Effects Models 263 8.6.3 Treatment Combination Models 264 8.7 Implications of Meta-Regression for Decision Making 266 8.8 Summary and Further Reading 268 8.9 Exercises 269 9 Bias Adjustment Methods 273 9.1 Introduction 273 9.2 Adjustment for Bias Based on Meta-Epidemiological Data 275 9.3 Estimation and Adjustment for Bias in Networks of Trials 278 9.3.1 Worked Example: Fluoride Therapies for the Prevention of Caries in Children 279 9.3.2 Extensions 285 9.3.3 Novel Agent Effects 286 9.3.4 Small-Study Effects 287 9.3.5 Industry Sponsor Effects 287 9.3.6 Accounting for Missing Data 288 9.4 Elicitation of Internal and External Bias Distributions from Experts 289 9.5 Summary and Further Reading 290 9.6 Exercises 291 10 *Network Meta-Analysis of Survival Outcomes 293 10.1 Introduction 293 10.2 Time-to-Event Data 294 10.2.1 Individual Patient Data 294 10.2.2 Reported Summary Data 295 10.2.3 Kaplan–Meier Estimate of the Survival Function 295 10.3 Parametric Survival Functions 296 10.4 The Relative Treatment Effect 298 10.5 Network Meta-Analysis of a Single Effect Measure per Study 300 10.5.1 Proportion Alive, Median Survival and Hazard Ratio as Reported Treatment Effects 300 10.5.2 Network Meta-Analysis of Parametric Survival Curves: Single Treatment Effect 300 10.5.3 Shared Parameter Models 301 10.5.4 Limitations 302 10.6 Network Meta-Analysis with Multivariate Treatment Effects 302 10.6.1 Multidimensional Network Meta-Analysis Model 302 10.6.1.1 Weibull 302 10.6.1.2 Gompertz 303 10.6.1.3 Log-Logistic and Log-Normal 303 10.6.1.4 Fractional Polynomial 304 10.6.1.5 Splines 304 10.6.2 Evaluation of Consistency 304 10.6.3 Meta-Regression 305 10.7 Data and Likelihood 305 10.7.1 Likelihood with Individual Patient Data 305 10.7.2 Discrete or Piecewise Constant Hazards as Approximate Likelihood 306 10.7.3 Conditional Survival Probabilities as Approximate Likelihood 307 10.7.4 Reconstructing Kaplan–Meier Data 307 10.7.5 Constructing Interval Data 308 10.8 Model Choice 308 10.9 Presentation of Results 309 10.10 Illustrative Example 310 10.11 Network Meta-Analysis of Survival Outcomes for Cost-Effectiveness Evaluations 319 10.12 Summary and Further Reading 320 10.13 Exercises 322 11 *Multiple Outcomes 323 11.1 Introduction 323 11.2 Multivariate Random Effects Meta-Analysis 324 11.3 Multinomial Likelihoods and Extensions of Univariate Methods 327 11.4 Chains of Evidence 328 11.4.1 A Decision Tree Structure: Coronary Patency 328 11.4.2 Chain of Evidence with Relative Risks: Neonatal Early Onset Group B Strep 330 11.5 Follow-Up to Multiple Time Points: Gastro-Esophageal Reflux Disease 332 11.6 Multiple Outcomes Reported in Different Ways: Influenza 335 11.7 Simultaneous Mapping and Synthesis 337 11.8 Related Outcomes Reported in Different Ways: Advanced Breast Cancer 342 11.9 Repeat Observations for Continuous Outcomes: Fractional Polynomials 344 11.10 Synthesis for Markov Models 345 11.11 Summary and Further Reading 347 11.12 Exercises 349 12 Validity of Network Meta-Analysis 351 12.1 Introduction 351 12.2 What Are the Assumptions of Network Meta-Analysis? 352 12.2.1 Exchangeability 352 12.2.2 Other Terminologies and Their Relation to Exchangeability 353 12.3 Direct and Indirect Comparisons: Some Thought Experiments 355 12.3.1 Direct Comparisons 356 12.3.2 Indirect Comparisons 359 12.3.3 Under What Conditions Is Evidence Synthesis Likely to Be Valid? 362 12.4 Empirical Studies of the Consistency Assumption 363 12.5 Quality of Evidence Versus Reliability of Recommendation 365 12.5.1 Theoretical Treatment of Validity of Network Meta-Analysis 365 12.5.2 GRADE Assessment of Quality of Evidence from a Network Meta-Analyses 366 12.5.3 Reliability of Recommendations Versus Quality of Evidence: The Role of Sensitivity Analysis 368 12.6 Summary and Further Reading 369 12.7 Exercises 373 Solutions to Exercises 375 Appendices 401 References 409 Index 447

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Book SynopsisWhy write a book on the tourniquet? The tourniquet is used routinely in op- ating theatres throughout the world, but as far as I know there is no single book that surveys the considerable literature that has accumulated.Trade ReviewFrom the reviews of the first edition: "The use of tourniquet in orthopaedic surgery is a universal practice that is accepted with little question. Leslie Klenerman has had a life-long interest in the tourniquet and has conducted a considerable amount of research on its use and misuse. … He has produced a succinct summary of the physiology and application of the tourniquet … . a very readable account that must be read by all who may require use of this instrument." (Frank Horan, Journal of Bone and Joint Surgery, Vol. 86-B, 2004) "The tourniquet is used daily in orthopaedic practice, and a lot of questions do not have a clear answer … . This little book covers the history, science and practical use of the tourniquet. … Complications, which often have medicolegal implication, are well described. This excellent book finds a place in all orthopaedic departments." (M. De Smedt, Acta Orthopaedica Belgica, Vol. 70 (6), 2004) "This is the first manual entirely devoted to the effects and potential complications of tourniquet use in surgery and anesthesia. It summarizes the scientific work published on the subject … . This original and very clearly presented little manual of 100 pages is of major interest for all tourniquet users, orthopaedic surgeons, anesthetists, and operating-theatre staff. It may also help experts, lawyers and attorneys, since medicolegal procedures can follow the onset of complications related to the use of tourniquets." (Claude Karger, European Journal of Orthopaedic Surgery & Traumatology, Vol. 14 (4), 2004)Table of ContentsHistorical Background.- Effect of a Tourniquet on the Limb and the Systemic Circulation.- Ischaemia-Reperfusion Syndrome.- Exsanguination of the Limb.- Complications.- The Tourniquet Used for Anaesthesia.- Technology and Practice.

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Book SynopsisDevelop the strong reasoning skills you'll need for competent and caring practice with An Introduction to Theory and Reasoning in Nursing. This proven book will help you understand theory, what it is, how it supports nurses and their practice and how you can use it to answer clinical questions and care for patients more effectively. -See theorists and their theories come to life with Theorist boxes that contain a brief synopsis of the theorist's life and a photo of the theorist (when available). -Access an alternative to nursing process care plans with a new research-validated reasoning model, the Clinical Reasoning Plan (CRP) that uses actual nursing case studies. -Increase your understanding of how theory and reasoning is used in clinical practice through Nursing Story boxes . -Clarify your understanding of individual support theories and nursing theories through Summaries that identify phenomenon, internal concepts or variables, propositions, external variables, and assumptions. -In

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Book SynopsisIn recent years, owing to the fast development of a variety of sequencing technologies in the post human genome project era, sequencing analysis of a group of target genes, entire protein coding regions of the human genome, and the whole human genome has become a reality.Table of ContentsPart I: Overview.- History of DNA Sequencing Technologies.- Clinical Molecular Diagnostic Techniques: A Brief Review.- Part II: The Technologies and Bioinformatics.- Methods of Gene Enrichment and Massively Parallel Sequencing Technologies.- Sequence Alignment, Analysis, and Bioinformatics Pipelines.- Protein Structural Based Analysis for Variant Interpretation of Missense Variants at the Genomics Era: Using MNGIE Disease as an Example.- Algorithms and Guidelines for Interpretation of DNA Variants.- Part III: Application to Clinical Diagnostics.- NGS-based Clinical Diagnosis of Genetically Heterogeneous Disorders.- Molecular Diagnosis of Congenital Disorders of Glycosylation (CDG).- NGS Improves the Diagnosis of X-Linked Intellectual Disability (XLID).- NGS Analysis of Heterogeneous Retinitis Pigmentosa.- Next Generation Sequencing of the Whole Mitochondrial Genome.- Application of Next-Generation Sequencing of Nuclear Genes for Mitochondrial Disorders.- ​Noninvasive Prenatal Diagnosis Using Next Generation Sequencing.- Part IV: Compliance with CAP/CLIA Regulations.- Guidelines and Approaches to Compliance with Regulatory and Clinical Standards: Quality Control Procedures and Quality Assurance.- Validation of NGS-based Test and Implementation of Quality Control Procedures.- Frequently Asked Questions about the Clinical Utility of Next Generation Sequencing in Molecular Diagnosis of Human Genetic Diseases.- Index.

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Book SynopsisThis book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention.Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-tTable of ContentsChapter 1 Histopathology and Pathogenesis of Vascular Tumors and MalformationsSara Szabo and Paula E. NorthChapter 2 Vascular OvergrowthKelly J. Duffy, Michael E. Kelly and David BickChapter 3 Vasculogenesis and AngiogenesisChang Zoon Chun, Rashmi Sood, and Ramani RamchandranChapter 4 The Genetic Basis and Molecular Diagnosis of Vascular Tumors and Developmental MalformationsMonte S. Willis and Tara SanderChapter 5 Clinical Management and Treatment of Vascular TumorsKristin E. Holland and Beth A. Drolet

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Book SynopsisThe taking in and use of food and other nourishing material by the body. Nutrition is a 3-part process. First, food or drink is consumed. Second, the body breaks down the food or drink into nutrients. Third, the nutrients travel through the bloodstream to different parts of the body where they are used as ''fuel'' and for many other purposes. To give the body proper nutrition, a person has to eat and drink enough of the foods that contain key nutrients. This book examines new research in this field which is belatedly receiving the proper attention.

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Book SynopsisPrinciples of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology.Written from the physician-scientist's perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field.KEY FEATURES: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable eBook

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Book SynopsisThis book sets out the unique and paradoxical position biomedical science finds itself in, in the early 21st (superscript st) century. Science has never been stronger in shaping the world we live in; progress in medical science during most of the last century has helped to transform health care and prolong our lives; almost daily advances in biological science promise hope for the future and yet medical science has been in serious decline for the past three decades.Biomedical Science in the 21st (superscript st) Century: Sunset or New Dawn? sets out the recent decline in the context of medical science's stunning past successes. Professor Sheridan discusses the failure to translate new discoveries in biological science into medical advances; the dramatic decline in research productivity in the pharmaceutical industry in the context of falling numbers of clinical scientists; the disruption of medical science during prolonged and repeated reforms of health care delivery; changing social and political attitudes towards health care and science; the loss of trust in big pharmaceutical companies and recent revelations of fraud in science. The book deals with the creative nature of original science, how it is driven by curiosity and self-motivation and how these can be stifled by pettifogging managerialism.The book presents a vision of what medical science can deliver during the coming half century and what is needed to overcome the present challenges. It questions the assumptions that big is best in the organisation of science and suggests a new model for drug development based on a restoration of trust and a more constructive relationship between regulators and industry.Table of ContentsThe Rise and Fall of Medical Science in the 20th Century; Advances in Medicine: How Are They Made?; The Impact of the Changing Social, Political and Economic Environment on Medical Science; Fraud in Biomedical Science; The Decline of Biomedical Science Despite Unprecedented Technological Advances: A 21st Century Paradox; Changes in Medical Professionalism in the 21st Century and Their Impact on Medical Science; The Global Demographic Challenge: The Role of Medical Science; Biomedical Science in Modern Economies: Innovation and Health; The Centrality of Medical Science in the 21st Century: Protecting Health and Meeting Future Economic Challenges.

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Book SynopsisHow do we know whether a particular treatment really works? How reliable is the evidence? And how do we ensure that research into medical treatments best meets the needs of patients? These are just a few of the questions addressed in a lively and informative way in Testing Treatments. Brimming with vivid examples, Testing Treatments will inspire both patients and professionals. Building on the success of the first edition, Testing Treatments has now been extensively revised and updated. The Second Edition includes a thought-provoking chapter on screening, explaining why early diagnosis is not always better. Other new chapters explore how over-regulation of research can work against the best interests of patients, and how robust evidence from research can be drawn together to shape the practice of healthcare in ways that allow treatment decisions to be reached jointly by patients and clinicians. Testing Treatments urges everyone to get involved in improving current research and future treatment, and outlines practical steps that patients and doctors can take together.

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Book SynopsisThis book introduces the fundamentals of biobanking and guides through the practical planning thereof, with a special focus on the situation in low- and middle-income countries. On the example of the setup of a Ukrainian biobank the book discusses the main steps and aspects of successful biorepository implementation and management. Topics covered include collection, storage and shipping of samples, establishment of an IT system, development of a sustainability plan, and project and risk management. Furthermore, the importance of the formation of international biobanking societies such as the Ukraine Association of Biobanks is highlighted, and their main objectives and tasks are discussed.The book addresses life science and business professionals as well as national authorities who are interested in biobanking in general and in setting up a biobank in particular. Table of Contents1. Introduction1.1. Literature Review1.1.1. Definition of biobanks1.1.2. Problems and the destitution for principle1.2 Scientific relevance of biobanks. Examples of biobanks1.2.1. Types of biobanks1.3. Ethical and legal principles1.4. Biobank management model and sustainability plan 1.4.1. SWOT analysis1.4.2. The mission1.5. Concepts specific for developing countries2. Methods2.1. Questionnaire: Survey development and content, participant selection2.2. Interviews: market analysis2.3. Team meetings: Development and implementation3. Results and summary of findings3.1. Step I: Ethics and law in the Ukraine Biobank3.1.1. Ethical regulations3.1.2. Access Policy3.2. Step II: Collection and Management of Samples3.2.1. Clarification of Conditions of Shipment of Samples3.2.2. Clinical Collection3.3. Step III: Risk Management and Biobanking3.4. Step IV: Quality Management and Quality Control. Quality Control Samples and SOP`s3.4.1. Quality Control Samples and SOP3.5. Step V: Governance and Stakeholder analysis3.6. Biobanking IT system3.6.1. Data base structure3.6.2. Web application3.7. Ukraine Biobank management model and sustainability plan3.7.1. Ukraine Biobank management model3.7.2. Sustainability plan and Project management3.8. Established Biobank in Ukraine Association3.9. Development and Progress of Ukraine’s Biobank Network3.10. The way to standardization3.11. Sample Access Policy3.12. Science and Innovation of Ukraine Association of Biobank4. Discussion5. Conclusion 6. List of figures7. References8. Internet Sources

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Book SynopsisCancer screening is a prominent strategy in cancer control in the United States, yet the ability to correctly interpret cancer screening data eludes many researchers, clinicians, and policy makers. This open access primer rectifies that situation by teaching readers, in simple language and with straightforward examples, why and how the population-level cancer burden changes when screening is implemented, and how we assess whether that change is of benefit. This book provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics. Concise, accessible, and focused, Assessment of Cancer Screening: A Primer is best suited to those with education or experience in clinical research or public health in the United States - no previous knowledge of cancer screening assessment is necessary. This is the first text dedicated to cancer screening theory and methodology to be published in 20 years.Table of ContentsFoundations.- Behind the scenes.- Performance measures.- Population measures: definitions.- Population measures: cancer screening’s impact.- Experimental research designs.- Observational research designs.- Cancer prevention screening.- Additional considerations.- Closing thoughts

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Book SynopsisThis is an open access book. In honor of his 75th birthday, we reflect on the impact of the pioneering work of Alan Grodzinsky and his laboratory. This volume includes in-depth discussions of tissue electromechanics, mechanobiology and biomechanics, and matrix biology in addition to the latest advancements in understanding the pathogenesis, progression and treatment of osteoarthritis. Unique to this volume, we overview decades of groundbreaking research that set the stage for the latest efforts in the field, highlighting the legacy of one researcher and their trainees.Table of ContentsPreface (Brianne K. Connizzo, Lin Han, Robert L. Sah).- Scientific Impact.- Chapter 1. Aggrecan and Hyaluronan: The infamous Cartilage Polyelectrolytes- Then and Now (Anna Plaas, Meghan Moran, John Sandy, Vincent Hascall).- Chapter 2. Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior (Byumsu Ki, Lawrence J. Bonassar).- Chapter 3. Multiscale In Silico Modeling of Cartilage Injuries (Rami K. Korhonen, Atte S.A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, and Petri Tanska).- Chapter 4. In Vitro Models and Proteomics in Osteoarthritis Research (Martin Rydén, Patrik Önnerfjord).- Chapter 5. Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration (Chao Wang, Elizabeth R. Kahle, Lin Han).- Chapter 6. Computational Modelling for Managing Pathways to Cartilage Failure (Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang).- Chapter 7. Gene Delivery to Chondrocytes (Christopher V. Nagelli, Christopher H. Evans, Rodolfo E. De la Vega).- Chapter 8. Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies (Bodo Kurz, Melanie L Hart, Bernd Rolauffs).- Chapter 9. Hip Osteoarthritis: Bench to Bedside Perspective (Young-Jo Kim).- Chapter 10. Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair (Stephen B. Trippel).- Personal Tributes.- Index.

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Book SynopsisThe aim of these lecture notes is to give an introduction to several mathematical models and methods that can be used to describe the behaviour of living systems. This emerging field of application intrinsically requires the handling of phenomena occurring at different spatial scales and hence the use of multiscale methods.Modelling and simulating the mechanisms that cells use to move, self-organise and develop in tissues is not only fundamental to an understanding of embryonic development, but is also relevant in tissue engineering and in other environmental and industrial processes involving the growth and homeostasis of biological systems. Growth and organization processes are also important in many tissue degeneration and regeneration processes, such as tumour growth, tissue vascularization, heart and muscle functionality, and cardio-vascular diseases.Table of ContentsPreface.- Cell-based, continuum and hybrid models of tissue dynamics.- The Diffusion Limit of Transport Equations in Biology.- Mathematical Models of the Interaction of Cells and Cell Aggregates with the Extracellular Matrix.- Mathematical modeling of morphogenesis in living materials.- Multiscale computational modelling and analysis of cancer invasion.

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Book SynopsisThis book discusses in detail various serological tests that are used to identify medical conditions and diseases, from a general overview of each test to the equipment and steps needed to carry them out. The book is aimed specifically at immunology students and professionals who may occasionally need to use these tests, and thus lack training and experience in performing them. The book provides a brief overview of the immune system, including antibodies, antigens, and their interactions. The bulk of the book is comprised of 16 chapters that each explain different serological tests. These chapters start with a general introduction of the test or disease being detected, followed by the test principle, reagents required for the test, procedures and steps to perform the test, and, finally, result interpretation. Both test principles and result interpretation segments include illustrations to aid comprehension. In addition, the book also enables the reader to distinguish between positive and negative results in serological testing.Table of ContentsForeword.- Preface.- Acknowledgements.- Introduction to the Immune System.- Antibody and antigen interaction.- Precipitation and Agglutination Reactions.- Rapid Plasma Reagin (RPR) Test.- Treponema pallidum heamagglutination (TPHA) Test.- Stained Brucella suspensions.- Rheumatoid Factor (RF).- Suspension Anti-streptolysin-O (ASO/ASL) Test.- C-Reactive Protein (CRP) Latex Agglutination Test.- Complement fixation Test (CFT).- Radioimmunoassay (RIA).- Enzyme-immunoassay (EIAs) and Enzyme-linked immunosorbent (ELISA).- Pregnancy Test.- Radial immunodiffusion (RID).- Immunofixation electrophoresis (IFE).- Immunofluorescence assay (IF).

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Table of ContentsIntroductory Remarks.- Methodology and Physiology Chairmen: G.V.R. Born and K. Breddin.- The Platelet as an Inflammatory Cell.- Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders.- The Mathematical Analysis of the Human Platelet Aggregation Mechanism and Its Clinical Application.- Quantitative Valuation of Platelet Aggregation Curves through the Calculation of a Numerical Index.- The Polyunsaturated Fatty Acids in Human Platelets: Effects of Diet and Possible Functional Significance.- Enhanced Platelet Aggregation as a Risk Factor for Progress and Complications of Vascular Disease. New Findings with a Platelet Aggregation Test (PAT III) and on the Dependence of Different Aggregation Tests on Morphologic Platelet Changes.- Pathogenesis Chairmen: M. Anthony, T. Abe, E.J. Acheson, J.S. Meyer, J. Marshall, K.J. Zülch.- Thrombosis and Embolism as a Cause of Ischemic Cerebrovascular Disturbances. Analysis from a Series of 1000 Patients.- Platelet Adhesiveness and Cerebral Vascular Disease Revisited.- The Significance of Platelet Aggregation in Amaurosis Fugax.- Mechanisms of Platelet 5-Hydroxytryptamine Release in Migraine.- Experimental observations on Platelet Emboli in Focal Brain Ischemia.- Observations on Platelet Aggregability in the Acute Phase of Untreated Strokes.- Microembolism in the Nervous System.- Influence of Plasma Components in the Development of Conditions of Increased Platelet Aggregation Found in a Number of Vascular Diseases.- Mechanism Associated with Platelet Adhesiveness in Cerebrovascular Disease.- Regional Intravascular Coagulation and Microthrombosis in Traumatic Brain Lacerations in Man.- Platelet Aggregation in Cerebrovascular Patients.- In Vivo Effect of Cyclic AMP and Related Drugs on Platelet Function.- Platelet Hyperreactivity and Decreased Survival in Chronic Cerebrovascular Patients. Chronic Defibrination Syndrome?.- Arterial Hypertension and Platelet Aggregation in the Patho-Pathogenesis of Cerebrovascular Diseases.- Smoking, Cerebrovascular Diseases and Platelet Functions.- Contribution of Platelet Aggregation and Serotonin Release to Progressive Cerebral Infarction.- Effect of Agents which Modify Platelet Aggregation and/or Coagulation on Experimental Platelet Embolism and Intravascular Coagulation.- Platelet Abnormalities in Cerebrovascular Diseases.- Inhibition of Platelet Aggregation by Synthetic Organic Acids: Quantitative Relationships Between Chemical Structures and Biological Activities.- Some Observations of Platelet Changes in Atherosclerosis and Some Observations in the Platelet Alterations Before and After Antiaggregant Drugs in Normal and Atherosclerotics.- Pharmacology and Clinical Pharmacology Chairmen: C.A. Bouvier, W.S. Fields, O.N. Ulutin, A. Rascol.- Inhibition of Platelet Thrombus Formation by Pharmacological Agents.- A Long-Term Clinical Trial with Antiplatelet Agents in Cerebrovascular Ischemia: Biological and Methodological Aspects.- Effect of Aspirin and Dipyridamole on Platelet Function and on Neurologic Evaluation of Patients Affected by Stroke or Transient Ischemic Attacks.- The Pharmacologic Control of the Enhanced Platelet Aggregation in Preventive Neurology.- Aspirin in Cerebral Ischemia.- The Canadian Cooperative Studies of the Effect of Platelet-Suppressing Drugs in Transient Cerebral Ischemic Attacks.- On the Relationships Between the Activation of the Complement System and the Platelet Aggregation.- Discussion and Concluding Remarks.- Chairmen’s Considerations.- Concluding Remarks.

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Book SynopsisThe common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a ‘cure’ for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of experts from epidemiologists to virologists and pharmacologists to look at recent advances in our knowledge of the common cold. In some respects the book is unique, as it focuses on the common cold, a syndrome so familiar to the layperson but one that receives little attention from the scientist and clinician. The common cold can be viewed from many different aspects as illustrated in Figure 1. The core knowledge for understanding the common cold must first come from virology and this is discussed in several chapters of the book. There have been major advances in this field because of the use of new methods of detecting viruses such as polymerase chain reaction techniques that have greatly aided our understanding of the epidemiology of viruses associated with common cold.Trade ReviewFrom the reviews: “This is an interesting and comprehensive monograph on the syndrome familiar to us all as ‘the common cold’. … the editors have generally avoided repetition and many of the chapters are data-rich, with good overviews of the epidemiology and treatments, many of which are refreshingly up-to-date. … The book also contains a wealth of useful background information on the economic and societal impact of the common cold, and is recommended for institutional purchase.” (David J. Evans, Microbiology Today, August, 2010)Table of ContentsA short history of the common cold.- Mechanisms of symptoms of common cold and flu.- Common respiratory infections diagnosed in general practice.- Epidemiology.- The role of viruses in the etiology and pathogenesis of common cold.- Etiology of the common cold: Modulating factors.- Host defenses.- Transmission of colds.- Interventions to prevent transmission of the common cold.- Antivirals for the common cold.- Antibiotic use for common cold.- Over the counter medicines for colds.- Vitamins and minerals.- Herbal, traditional and alternative remedies.

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Book SynopsisList of Contributors ix PART 1 CURRENT CONCEPTS OF HEALTH AND HEALTH CARE 1 A European overview of the health care scene KS Johansen 3 Is there a European concept of health and health care? 2 JGW Wittkiimper 7 3 The effects of health and safety legislation on the practice of clinical laboratory science A Berlin, AE Bennett and WJ Hunter 19 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery JG Lines and N Sanders 33 PART 2 THE CLINICAL LABORATORY IN THE CHANGING SCENE OF HEALTH CARE 5 The clinical laboratory in the changing scene of health care as seen by a professional society member M Roth 41 6 The clinical laboratory in the changing scene of health care as seen by an industry member JE Barclay 45 7 The clinical laboratory in the changing scene of health care as seen by a health agency member R Netter 55 8 The clinical laboratory in the changing scene of health care as seen in the USA R Nadeau 59 v CONTENTS PART 3 WOULD THE VALUE OF CLINICAL LABORATORY SCIENCE BE INCREASED BY FURTHER WRITTEN AND MATERIAL STANDARDS? 9 Would the value of clinical laboratory science be increased by further written and material standards in histology? J Rygaard 67 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology? OAN Husain 73 11 Would the value of clinical laboratory science beTable of Contents1 Current Concepts of Health and Health Care.- 1 A European overview of the health care scene.- 2 Is there a European concept of health and health care?.- 3 The effects of health and safety legislation on the practice of clinical laboratory science.- 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery.- 2 The Clinical Laboratory in the Changing Scene of Health Care.- 5 The clinical laboratory in the changing scene of health care as seen by a professional society member.- 6 The clinical laboratory in the changing scene of health care as seen by an industry member.- 7 The clinical laboratory in the changing scene of health care as seen by a health agency member.- 8 The clinical laboratory in the changing scene of health care as seen in the USA.- 3 Would The Value Of Clinical Laboratory Science be Increased by Further Written and Material Standards?.- 9 Would the value of clinical laboratory science be increased by further written and material standards in histology?.- 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology?.- 11 Would the value of clinical laboratory science be increased by further written and material standards in microbiology?.- 12 Would the value of clinical laboratory science be increased by further written and material standards in immunology?.- 13 Would the value of clinical laboratory science be increased by further written and material standards in haematology?.- 14 Would the value of clinical laboratory science be increased by further written and material standards in clinical chemistry?.- 15 Would the value of clinical laboratory science be increased by further written and material standards in toxicology?.- 4 Future Eccls Involvement.- 16 Future ECCLS involvement as seen by industry.- 17 Future ECCLS involvement as seen by health agencies.- 18 Future ECCLS involvement as seen by professional societies.

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Book SynopsisThis book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.Table of ContentsPart I Principles of Clinical Molecular DiagnosticsChapter 1 Molecules of Diseases and Their Detection Methods Chapter 2 Assay Performance Evaluation Chapter 3 Establishment of Biological Reference Interval Chapter 4 Ethics: Informed Consent, Patient Privacy Chapter 5 Bioinformatics Chapter 6 Report and Consultation Chapter 7 Factors Associated with Variation Chapter 8 Quality Control and Quality Assurance Chapter 9 Precision Medicine Part 2 Molecular Biomarkers and Signals from Diseased Functional Organ Chapter 10 Molecules in Body Systems Chapter 11 Molecules in Signal Pathways Chapter 12 Endocrine and Metabolism Chapter 13 Immune System Chapter 14 Lipoproteins Chapter 15 Transport and Carrier Proteins Chapter 16 Coagulation and Fibrinolysis Chapter 17 Cardiovascular System Chapter 18 Pregnancy Chapter 19 Urine Chapter 20 Bone Chapter 21 Cancer Chapter 22 Translation Research of Novel Biomarker Part 3 Advanced Molecular Diagnostic Techniques Chapter 23 Next-generation Sequencing (NGS) Chapter 24 Digital PCR Chapter 25 Biosensor Chapter 26 Microfluidic Chip Chapter 27 Liquid Biopsy Chapter 28 Molecular Targeted Imaging Chapter 29 Fluorescence in Situ Hybridization Chapter 30 Circulating DNA Quantification Chapter 31 DNA Methylation Detection Techniques Part 4 Disease Presentation and Clinical Laboratory Procedures Chapter 32 Immunological Disorders Chapter 33 Liver Diseases Chapter 34 Pancreatic Diseases Chapter 35 Digestive Tract Disease Chapter 36 Kidney Diseases Chapter 37 Cardiovascular Disease Chapter 38 Lung Disease Chapter 39 Blood Disorders Chapter 40 Endocrine and Metabolic Diseases Chapter 41 Neurological Disease Chapter 42 Reproductive Organ Cancer Chapter 43 Reproductive Organ Cancer Chapter 44 Transplant Matching Chapter 45 Paternity Test

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Book SynopsisContaining helpful summaries and checklists throughout and based on Mazur's thirty years of research experience, this accessible and informative guide will give all IRB members the tools they need to protect human lives and facilitate the research process.Trade ReviewA well-written and informative narrative of the inner workings of IRBs. It is a must-read for those who are (or will be) members of an IRB and for those who need to submit a proposal. -- Maura Pilotti, Ph.D. Metapsychology 2007 An indispensable guide for both experienced and inexperienced IRB members... I would recommend it to any IRB member. Doody's Review Service 2007 Mazur's book provides IRB members with essential questions they should ask when reviewing proposed and ongoing studies. -- Karen J. Maschke New England Journal of Medicine 2007 The book contains an interesting perspective and a wealth of knowledge. It contains quite a lot of information for any single audience, but those who serve on IRBs can benefit greatly from reading and referring to Mazur's work. -- Alice Z. Frohna JAMA 2007 College-level holdings strong in medical and research issues or medical ethics will want this review. Midwest Book Review 2007 There is much to like about Evaluating the Science and Ethics of Research on Humans; its depth and sophistication... Not just Mazur's experience but the overall evolution of research administration is reflected in this volume. -- Kenneth A. DeVille Journal of Legal Medicine 2007 Every IRB member must read this book so that the participants of clinical trials benefit from it. -- Sanjay A. Pai Indian Journal of Medical Ethics 2008 The author applies extensive experience to illustrate the depth of ethical reflection that research proposals can generate and provides guidance on how reflection can be directed to decision making... Checklists in the text and appendices afford IRB members and officers the comfort of knowing that little, if anything, has been overlooked in discharging ethics review. -- Bernard M. Dickens, PhD Annals of Internal Medicine 2008 The analysis of a study's risk-benefit ratio is especially good. U.S. Dept. of Energy, Office of Biological and Environmental Research 2007 Contains helpful summaries and checklists throughout based on the author's thirty years of research experience. Issues in Law and Medicine 2008Table of ContentsPrefaceIntroduction: What Can the New IRB Member Expect?Part I: The IRB, Its Work, and Its Challenges1. What Is an IRB, and What Does It Do?2. Basic Terms and Concepts Used in IRB Work3. What Is Risk?Part II: The Scientific Protocol and the Informed Consent Form4. Prescreening of Proposals5. The Scientific Protocol6. The Informed Consent Form7. Recruitment, Selection, and Compensation of Study Participants8. Research involving Questionnaires and Surveys9. Protection of Participants' Privacy in Research Dataand SpecimensPart III: The Continuing Work of the IRB10. The Ethical Issues of Informed Consent11. Continuing Review, Communication, and Feedback12. Where Are IRBs Making Mistakes, and How Can We Minimize Mistakes?13. Strategies for Managing the IRB Workload and Supporting IRB Decision Making14. Decision-Making Capacity and Accountability in ResearchSummary: The IRB's Key RoleAppendix 1: A Check List for Reviewing a Scientific ProtocolAppendix 2: A Check List for Reviewing an Informed Consent FormNotesWebsite References for Cited DocumentsIndex

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Book SynopsisMenopause affects 51% of the population. Yet despite increased awareness in recent years, so much of the menopause remains a mystery. Here, Dr Louise Newson, the UK's leading menopause specialist, breaks remaining taboos with the definitive guide to menopause. The Definitive Guide to the Perimenopause and Menopause starts with the key facts about hormones, their importance and their effects on our bodies, before delving into family histories and their effects on menopause, the essential guide to HRT, our libidos, our mental and physical health, how menopause affects our careers and relationships and so much more. Dr Louise Newson covers five key elements: 1. The essentials: must-know information that is evidence-based and accessible. 2. Exclusive research and findings from Dr Newson's non-profit Newson Health Research and Education and Balance community. 3. Common questions women want to know answered. 4. Real stories: Women share their own mTrade ReviewLouise is a voice you can really trust. I've learnt so much from her and now you can too. -- Holly WilloughbyDr Louise is a miracle worker -- Lorraine KellyLouise Newson is wonderful... a real expert in her field. -- Joe WicksDr Louise Newson is a fantastic authority on the menopause who has helped 100,000s of women through her clinics, digital products and books. Her tireless campaigning and expertly crafted content helps women around the world to better understand the menopause, make evidence based decisions and take control of their health. I recommend her work to all of my patients and colleagues. -- Dr Rupy Aujla, MBBS, BSc, MRCGP founder of "The Doctor's Kitchen"The medic who kickstarted the menopause revolution. -- Lorraine Candy, Journalist * The Sunday Times *Louise has brought the conversion about the menopause to the foreground much to the relief of lots of women and is championing adequate availability of adequate hormone replacement as well as advocating healthy lifestyle -- Miss Claire Mellon, Consultant Obstetrician and GynaecologistDr Louise Newson is an experienced GP and one of a few top UK experts on the menopause who has helped hundreds of thousands of women through her clinic, app and websites. This book should help many more! -- Professor Tim SpectorIt is impossible to overstate the pioneering role Dr Louise Newson has played in bringing menopause education to public awareness. I found this impassioned and comprehensive book so instructive. Readers are incredibly lucky to get the benefit of her decades of expertise. -- Tamsen Fadal, Journalist, Menopause Advocate, Podcaster

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Book SynopsisThis book demonstrates how qualitative methods can be used to address research issues pertinent to mental health practice and psychotherapy. With contributions from leading researchers, the book examines how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to approach ethical issues.Trade Review“In a field that at times feels dominated by obfuscating jargon and a cult-like zeal, the editors have produced an accessible, illuminating text that will be of great value to those wishing to gain an introduction to this essential and developing area of mental health research.” (The British Journal of Psychiatry, 1 May 2012) "David Harper and Andrew Thompson’s book Qualitative Research Methods in Mental Health and Psychotherapy provides a reference for students and practitioners who are using qualitative research to explore topics related to mental health. The book provides a rich and comprehensive text, with contributions from specialized authors on a number of key themes and research methods relevant to qualitative research. Despite being specifically aimed at those researching mental health issues, this text would be useful for any student or practitioner who wishes to get to grips with ‘big q research’..." (Feminism and Psychology, 2013) “Since receiving this book for review, I have found myself repeatedly recommending it to fellow doctoral researchers from a range of professional backgrounds, at all stages of candidature. I do so because, in my opinion, this book addresses, in an accessible, clear, yet thorough manner, the issues which all students and practitioner-researchers face in aspiring to produce high quality, creative, qualitative research in mental health and psychotherapy.” (QMiP Bulletin Issue 15, Spring 2013) Table of ContentsAbout the Contributors. Acknowledgements. PART I Getting Started. 1 Introduction (Andrew R. Thompson and David Harper). 2 Identifying and Synthesizing Qualitative Literature (Rachel L. Shaw). 3 Ethical Issues in Qualitative Mental Health Research (Andrew R. Thompson and Eleni Chambers). 4 Participation and Service User Involvement (Alison Faulkner). 5 Qualitative Data Collection: Asking the Right Questions (Hannah Frith and Kate Gleeson). 6 Qualitative Methods for Studying Psychotherapy Change Processes (Robert Elliott). 7 Choosing a Qualitative Research Method (David Harper). PART II Methods. 8 Interpretative Phenomenological Analysis in Mental Health and Psychotherapy Research (Michael Larkin and Andrew R. Thompson). 9 Existentialist-Informed Hermeneutic Phenomenology (Carla Willig and Abigail Billin). 10 Grounded Theory Methods for Mental Health Practitioners (Alison Tweed and Kathy Charmaz). 11 Discourse Analysis (Eugenie Georgaca and Evrinomy Avdi). 12 Narrative Psychology (Michael Murray and Sally Sargeant). 13 Ethnomethodology/Conversation Analysis (Mark Rapley). 14 Q Methodological Research in Mental Health and Psychotherapy (Wendy Stainton Rogers and Phillip O. Dyson). 15 Thematic Analysis (Helene Joffe). PART III Establishing Good Quality Qualitative Research in Mental Health. 16 In Pursuit of Quality (Liz Spencer and Jane Ritchie). 17 Emerging Issues and Future Directions (David Harper and Andrew R. Thompson). Index.

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Book SynopsisHypotheses are fundamental to all sciences, including medicine. They play a critical role in motivating the development of science, since interesting and important hypotheses foster the diversity and debate upon which the scientific process depends. It is necessary to learn and understand how to assess a process, realise and discuss details and consequently launch a hypothesis. This book offers a number of novel, non-mainstream hypotheses in various states of development from authors with relevant expertise and experience.

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Book SynopsisSarcoidosis is a multisystem granulomatous disease of unknown etiology. It can occur at all ages, with the incidence peaking at 20 to 40 years. This book reviews the epidemiology, etiology, pathology, clinical manifestations, diagnosis and management strategies of sarcoidosis, while highlighting recent studies that have provided new insights into this unique and debilitating disease. The authors also specifically point out the urological manifestations of sarcoidosis to avoid misdiagnoses and to provide early intervention.

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Book SynopsisTrade Review...the book has much to commend it to qualifying practitioners, their tutors and practice educators.—The British Journal of Social Work...[the authors] offer credible practice-researchable examples from social work, nursing, physical therapy, education, and other practice contexts and the application of multiple methods to answer questions that emanate from those fields of practice. How do they know all this stuff?—Journal of Social WorkTable of ContentsPreface1. An Introduction to Practitioner Research2. Orientation3. Focusing4. Planning5. Data Collection6. Analysis and Conclusion7. Design and Innovation8. Documentation and PresentationAppendix. Using SourcesIndex

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Book SynopsisWhat if everything you know about salt is wrong? A leading cardiovascular research scientist explains how this vital crystal got a negative reputation, and shows how to lower blood pressure and experience weight loss using salt. The Salt Fix is essential reading for everyone on the keto diet!   We’ve all heard the recommendation: eat no more than a teaspoon of salt a day for a healthy heart. Health-conscious Americans have hewn to the conventional wisdom that your salt shaker can put you on the fast track to a heart attack, and have suffered through bland but “heart-healthy” dinners as a result.    What if the low-salt dogma is wrong?    Dr. James DiNicolantonio has reviewed more than five hundred publications to unravel the impact of salt on blood pressure and heart disease. He’s reached a startling conclusion: The vast majority of us don’t need t

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Book SynopsisMolecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences.Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the reader up to date with specific topics in cancer research, how the topics give rise to development of new informatics and statistics tools, and how the tools can be applied. The focus of the book is to give the reader an understanding of keyTable of ContentsPREFACE ; 1. Association Studies ; 2. Methods for DNA Copy Number Derivations ; 3. Methods for Derivation of LOH and Allelic Copy Numbers Using SNP Arrays ; 4. Bioinformatics of gene expression and copy number data integration ; 5. Analysis of DNA Methylation in Cancer ; 6. Pathway Analysis: Pathway Signatures and Classification ; 7. Two Methods for Comparing Genomic Data Across Independent Studies in Cancer Research: Meta-analysis and Oncomine Concepts Map ; 8. Bioinformatic Approaches to the Analysis of Alternative Splicing Variants in Cancer Biology ; INDEX

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