Medical research Books

Book SynopsisJetzt kommt Bewegung in die Biochemie!Die ganze Welt der Biochemie und Pathobiochemie in 74 überschaubaren Kapiteln und über 1000 Abbildungen erklärt – da bleibt keine Frage offen.Und mehr noch, damit Sie die komplexen Vorgänge in Stoffwechsel, Signaltransduktion und Molekularbiologie schneller verstehen, sind mit der kostenlosen MoreMediaApp fast 400, teils vertonte Videos direkt aus dem Buch abrufbar – einfach das Bild mit dem Smartphone oder Tablet scannen und schon werden Citratzyklus, DNA-Replikation und Co. lebendig! So lässt sich auch später in der Klinik schnell etwas wiederholen – Film ab und das biochemische Hintergrundwissen ist aufgefrischt.Außerdem bietet die Biochemie und Pathobiochemie: 74 überschaubare Kapitel für einen guten Überblick Auflistung der Schwerpunkte am Kapitelanfang Einen Roten Faden, der kleine Abschnitte kurz zusammenfasst Zusammenfassungen am Kapitelende Tafelteil mit den wichtigsten Strukturformeln zum Nachschlagen Wie wichtig das Wissen über Moleküle, Mechanismen und Signalwege für das Verständnis pathologischer Vorgänge ist, wird anhand zahlreicher spezieller Abschnitte oder eigener Kapitel zur Pathobiochemie herausgestellt. Schließlich geben spannende Exkurse und Hintergrundinfos einen Blick über den Tellerrand oder weiter in die Tiefe.Biochemie ausführlich und animiert – Ihr Begleiter durchs ganze Studium!Table of ContentsI Grundlagen der Biochemie und Molekulären Zellbiologie: Ohne Wasser kein Leben.- Vom Molekül zum Organismus.- Kohlenhydrate, Lipide, Aminosäuren und Nucleotide - Bausteine des Lebens,mitTafelteil.- Thermodynamik und Bioenergetik.- Proteine - Struktur und Funktion.- Proteine – Analytische Untersuchungsmethoden, Synthese und Isolierung.- Enzyme - Molekulare und funktionelle Grundlagen der Biokatalyse.- Regulation der Enzymaktivität.- Enzyme in Analytik, Diagnoste und Therapie.- Nucleinsäuren - Struktur und Funktion.- Biokatalyse.- Zellorganellen und Vesikeltransport. Cytoskelett.-II Zellulärer Metabolismus: Glucose – Schlüsselmolekül des Kohlenhydratstoffwechsels.- Mechanismen der Glucosehomöostase.- Zucker - Bausteine von Glycoproteinen und Heteroglycanen.- Pathobiochemie des Kohlenhydratstoffwechsels.- Der Citratzyklus – Abbau von Acetyl-CoA zu CO2 und H2O.- Mitochondrien – Organellen der ATP-Gewinnung.- Oxidoreduktasen und reaktive Sauerstoffspezies.- Lipogenese und Lipolyse - Bildung und Verwertung der Fettspeicher.- Stoffwechsel von Phosphoglyceriden und Sphingolipiden.- Stoffwechsel von Cholesterin.- Lipoproteine - Transportformen der Lipide im Blut.- Pathobiochemie des Lipidstoffwechsels.- Prinzipien von Aminosäurestoffwechsel und Stickstoffumsatz.- Funktioneller Aminosäurestoffwechsel.- Pathobiochemie des Aminosäurestoffwechsels.- Purinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pyrimidinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pathobiochemie des Purin- und Pyrimidinstoffwechsels.- Porphyrine - Synthese und Abbau.- III Zelluläre Kommunikation: Prinzipien zellulärer Kommunikation.- Mediatoren.- Rezeptoren und ihre Signaltransduktion.- Insulin - das wichtigste anabole Hormon.- Glucagon und Katecholamine - Gegenspieler des Insulins.- Integration und hormonelle Regulation des Energiestoffwechsels.- Hormone des Hypothalamus und der Hypophyse.- Steroidhormone – Produkte von Nebennierenrinde und Keimdrüsen.- Schilddrüsenhormone – Zentrale Regulatoren von Entwicklung, Wachstum, Grundumsatz, Stoffwechsel und Zelldifferenzierung.- Wachstumshormon und Prolactin.- IV Molekularbiologie: Zellzyklus – Koordination der Zellteilung.- Replikation –Die Verdopplung der DNA.- DNA-Mutationen und ihre Reparatur.- Transkription und Prozessierung von RNA.- Regulation der Transkription – Aktivierung und Inaktivierung der Genexpression.-Translation – Synthese von Proteinen.- Proteine - Transport, Modifikation und Faltung.- Proteine – Mechanismen ihres Abbaus.- Der programmierte Zelltod - Apotose, Nektrotose, Ferroptose und Pyroptose.- Prinzipien der zellulären Tumorgenese und –progression.- Das Tumorstroma.- Gentechnik.- Gentechnik in höheren Organismen – Transgene Tiere und Gentherapie.- V Funktionelle Biochemie der Organe: Energiebilanz und Ernährungszustand.- Makronährstoffe und ihre Bedeutung.- Fettlösliche Vitamine.- Wasserlösliche Vitamine.- Spurenelemente.- Gastrointestinaltrakt.-Leber - Zentrales Stoffwechselorgan.- Quergestreifte Muskulatur.- Die glatte Muskulatur.- Niere – Ausscheidung von Wasser und Elektrolyten.- Niere – Der Säure-Basen- und Mineralhaushalt.- Blut – Zelluläre Bestandteile und Blutplasma.- Blut – Hämatopoese und Erythrocyten.- Blut – Thrombocyten und Leukocyten.- Immunologie.- Extrazelluläre Matrix - Struktur und Funktion.- Knorpel- und Knochengewebe.- Haut.- Nervensystem.- Anhang.

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Book SynopsisIn diesem Buch sind Lehrbeispiele gesammelt, die Dozierenden wertvolle Anregungen für ihre eigene Lehre liefern: Es werden Ideen für einzelne Übungen, Unterrichtseinheiten, Prüfungen oder ganze Kurse vorgestellt. Die benötigten Materialien sind für die Nutzer online frei verfügbar, um die Anwendung zu vereinfachen. Alle Beiträge dieses Buches wurden 2020 für den Preis für das beste Health-Data-Science-Lehrmaterial eingereicht, der von der Arbeitsgruppe Lehre und Didaktik der Biometrie der Deutschen Region der Internationalen Biometrischen Gesellschaft und der GMDS ausgeschrieben wurde. So entstand ein breiter Querschnitt an Beiträgen für lebendige Lehre in Biometrie, Epidemiologie, Public Health und ähnlichen Gebieten. Das Buch knüpft damit an die beiden Bände Zeig mir Biostatistik! und Zeig mir mehr Biostatistik! an, denen ähnliche Ausschreibungen vorausgingen. Die Herausgeber unterrichten Biometrie als Haupt- oder Nebenfach an verschiedenen Universitäten bzw. Hochschulen. Es verbindet sie das gemeinsame Ziel, den Austausch von Ideen und ausgereiftem Unterrichtsmaterial im Bereich Health Data Science zu fördern.Table of ContentsStatistischer Humor im Unterricht.- Personalisierte Medizin live erleben.- Herr Herbinger hat ein Herzproblem.- Der richtige Mix macht’s.- Ein (didaktischer) Werkzeugkasten für ein effektives R Training.- Biostatistik trifft auf OMICS.- Methoden zur Abwechslung, Auflockerung und Aktivierung in der (Biometrie-)Lehre.- Spielerisch Daten reinigen.- Flipped Classroom mit SAS on Demand.- P-Wert im Geldbeutel?.- Biomathe kann begeistern!.- Einsatz von Audience Response Systemen in der Lehre.

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Book SynopsisThe focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book.This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.Table of ContentsForeword.- Introduction.- Part I: Chemical Biology and Drug Development.- Chemical Biology - a Holistic Science.- Drug Development.- From Genomics to Chemical Biology.- Part II: DNA.- DNA - blueprint of proteins.- Genomic Variation.- Gene Therapy and Genome Editing.- Part III: RNA.- RNA - information and function carrier.- RNA Interference in Drug Development.- Part IV: Proteins.- Peptides & proteins.- Proteins as drug targets.- Chemical genomics - From target protein to drug.- From target protein to macromolecular drug - Biologics.- Chemical proteomics: From drug to target protein.- Chemical genetics: validation of drug target by elucidation of signaling pathway.- Chemical biology - Addressing new drug targets.

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Book SynopsisThe common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a ‘cure’ for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of experts from epidemiologists to virologists and pharmacologists to look at recent advances in our knowledge of the common cold. In some respects the book is unique, as it focuses on the common cold, a syndrome so familiar to the layperson but one that receives little attention from the scientist and clinician. The common cold can be viewed from many different aspects as illustrated in Figure 1. The core knowledge for understanding the common cold must first come from virology and this is discussed in several chapters of the book. There have been major advances in this field because of the use of new methods of detecting viruses such as polymerase chain reaction techniques that have greatly aided our understanding of the epidemiology of viruses associated with common cold.Trade ReviewFrom the reviews: “This is an interesting and comprehensive monograph on the syndrome familiar to us all as ‘the common cold’. … the editors have generally avoided repetition and many of the chapters are data-rich, with good overviews of the epidemiology and treatments, many of which are refreshingly up-to-date. … The book also contains a wealth of useful background information on the economic and societal impact of the common cold, and is recommended for institutional purchase.” (David J. Evans, Microbiology Today, August, 2010)Table of ContentsA short history of the common cold.- Mechanisms of symptoms of common cold and flu.- Common respiratory infections diagnosed in general practice.- Epidemiology.- The role of viruses in the etiology and pathogenesis of common cold.- Etiology of the common cold: Modulating factors.- Host defenses.- Transmission of colds.- Interventions to prevent transmission of the common cold.- Antivirals for the common cold.- Antibiotic use for common cold.- Over the counter medicines for colds.- Vitamins and minerals.- Herbal, traditional and alternative remedies.

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Book SynopsisVorwort.- 1 Einführung.- 2 Likelihood.- 3 Frequentistische Eigenschaften der Likelihood.- 4 Likelihood-Inferenz bei vektoriellem Parameter.- 5 Bayer-Inferenz.- 6 Modellwahl.- 7 Numerische Methoden zur Bayes-Inferenz.- 8 Prognose.- A Ergänzungen aus der Stochastik.- B Ergänzungen aus der linearen Algebra und Analysis.- C Ergänzungen aus der Numerik.- Literaturverzeichnis.- Index.

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Book SynopsisWhen new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a stronger urge to do more for these mysterious and hidden mini-organs that are directly or indirectly involved in the pathogenesis of all forms of diabetes that affects ?250 million people in the world. After I launched the Islet (landesbioscience. com/journals/islets) and founded the Islet Society (isletso- ety. org), there was a momentum that could be utilized to create something equally meaningful i. e. this book. The idea cracked in September 2008. Starting September 19, 2008, I contacted an estimated 90% of the authors who published anything on the islets during 2007–2008 and who could be traced from the internet.Trade Review"It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!"Matthias von Herrath, MDProfessor and Director, Center for Type 1 Diabetes ResearchLa Jolla Institute for Allergy and Immunology, La Jolla CA, USA "This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge". Martha Pavlakis, MDAssociate Professor of Medicine, Harvard Medical SchoolMedical Director, Kidney and Pancreas TransplantationBeth Israel Deaconess Medical CenterBoston, MA, USA "The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely". Fred Levine, M.D., Ph.D.Professor, Burnham Institute for Medical ResearchDirector, Sanford Children's Health Research CenterLa Jolla, CA, USA "The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource".Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical SchoolMinneapolis, MN, USA "This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites".Prof. Pellegrino MasielloDept. of Experimental Pathology,University of Pisa,Pisa, Italy "The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes".Alvin C. Powers, M.D.Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and BiophysicsDirector, Vanderbilt Diabetes CenterVanderbilt UniversityNashville, TN USA "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research"Marc Prentki, PhDProfessor of Nutrition and BiochemistryCanada Research Chair in Diabetes and MetabolismMDRC DirectorMontreal, QCCanada Table of ContentsCHAPTER 1 : Microscopic anatomy of the human islet of Langerhans - Peter In't Veld and Miriam Marichal CHAPTER 2 : The comparative anatomy of islets - Scott Heller CHAPTER 3: Approaches for imaging of islets: recent advances and future prospects - Ulf Ahlgren and Martin Gotthardt CHAPTER 4: Islet-cell Development - Anabel Rojas, Adrian Khoo, Juan R. Tejedo, Francisco J. Bedoya, Bernat Soria and Franz Martín CHAPTER 5: High fat programming of b-cell failure - Marlon. E. Cerf CHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghan CHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina Düfer CHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter Proks CHAPTER 9: Role of mitochondria in b-cell function and dysfunction - Pierre Maechler, Ning Li, Marina Casimir, Laurène Vetterli, Francesca Frigerio, Thierry Brun CHAPTER 10: Basement membrane in pancreatic islet function - Martin Kragl and Eckhard Lammert CHAPTER 11: Calcium signaling in the islets - Md. Shahidul Islam CHAPTER 12: Electrical bursting, calcium oscillations, and synchronization of pancreatic islets - Richard Bertram, Arthur Sherman, and Leslie S. Satin CHAPTER 13: Cyclic AMP signaling in pancreatic islets - Brian Furman, Wee Kiat Ong, and Nigel Pyne CHAPTER 14: Exocytosis in islet b-cells - Haruo Kasai, Hiroyasu Hatakeyama, Mitsuyo Ohno and Noriko Takahashi CHAPTER 15: The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function - Po Sing Leung CHAPTER 16: Proteomics and islets research - Meftun Ahmed CHAPTER 17: Wnt signaling in pancreatic islets - Zhengyu Liu and Joel F. Habener CHAPTER 18: Molecular pathways underlying the pathogenesis of pancreatic a-cell dysfunction - Dan Kawamori,Hannah J. Welters, and Rohit N. Kulkarni CHAPTER 19: Mechanisms of pancreatic b-cell apoptosis in diabetes and its therapies - James D. Johnson, Dan S. Luciani CHAPTER 20: b-cell function in obese-hyperglycaemic mice [ob/ob mice] - Per Lindström CHAPTER 21: Islet structure and function in the GK rat - B. Portha, G. Lacraz, A. Chavey, F. Figeac, M. Fradet, C. Tourrel-Cuzin, F. Homo-Delarche, M-H. Giroix, D. Bailbé, MN. Gangnerau, J. Movassat CHAPTER 22: The b-cell in human type 2 diabetes - Piero Marchetti, Roberto Lupi, Silvia Del Guerra, Marco Bugliani, Lorella Marselli and Ugo Boggi CHAPTER 23: Clinical approaches to preserve b-cell function in diabetes - Bernardo L. Wajchenberg CHAPTER 24: Immunology of b-cell destruction - Daria La Torre, and Åke Lenmark CHAPTER 25: Toll-like receptors and type 1 diabetes - Danny Zipris CHAPTER 26: Prevention of b-cell destruction in autoimmune diabetes: current approaches and future prospects - Saikiran K Sedimbi and Carani B Sanjeevi CHAPTER 27: In vivo regeneration of insulin-producing b-cell - Hee-Sook Jun CHAPTER 28: Customized cell-based treatment options to combat autoimmunity and restore b-cell function in Type I diabetes mellitus: current protocols and future perspectives - Fred Fändrich and Hendrik Ungefroren CHAPTER 29: The progammable cell of monocytic origin (PCMO): A potential adult stem/progenitor cell source for the generation of islet cells - Hendrik Ungefroren and Fred Fändrich CHAPTER 30: Islet isolation for clinical transplantation - Tatsuya Kin CHAPTER 31: Human islet autotransplantation: the trail thus far and the highway ahead - Martin Hermann, Raimund Margreiter and Paul Hengster CHAPTER 32: Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes - Lorenzo Piemonti, Luca G. Guidotti,

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Book SynopsisList of Contributors ix PART 1 CURRENT CONCEPTS OF HEALTH AND HEALTH CARE 1 A European overview of the health care scene KS Johansen 3 Is there a European concept of health and health care? 2 JGW Wittkiimper 7 3 The effects of health and safety legislation on the practice of clinical laboratory science A Berlin, AE Bennett and WJ Hunter 19 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery JG Lines and N Sanders 33 PART 2 THE CLINICAL LABORATORY IN THE CHANGING SCENE OF HEALTH CARE 5 The clinical laboratory in the changing scene of health care as seen by a professional society member M Roth 41 6 The clinical laboratory in the changing scene of health care as seen by an industry member JE Barclay 45 7 The clinical laboratory in the changing scene of health care as seen by a health agency member R Netter 55 8 The clinical laboratory in the changing scene of health care as seen in the USA R Nadeau 59 v CONTENTS PART 3 WOULD THE VALUE OF CLINICAL LABORATORY SCIENCE BE INCREASED BY FURTHER WRITTEN AND MATERIAL STANDARDS? 9 Would the value of clinical laboratory science be increased by further written and material standards in histology? J Rygaard 67 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology? OAN Husain 73 11 Would the value of clinical laboratory science beTable of Contents1 Current Concepts of Health and Health Care.- 1 A European overview of the health care scene.- 2 Is there a European concept of health and health care?.- 3 The effects of health and safety legislation on the practice of clinical laboratory science.- 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery.- 2 The Clinical Laboratory in the Changing Scene of Health Care.- 5 The clinical laboratory in the changing scene of health care as seen by a professional society member.- 6 The clinical laboratory in the changing scene of health care as seen by an industry member.- 7 The clinical laboratory in the changing scene of health care as seen by a health agency member.- 8 The clinical laboratory in the changing scene of health care as seen in the USA.- 3 Would The Value Of Clinical Laboratory Science be Increased by Further Written and Material Standards?.- 9 Would the value of clinical laboratory science be increased by further written and material standards in histology?.- 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology?.- 11 Would the value of clinical laboratory science be increased by further written and material standards in microbiology?.- 12 Would the value of clinical laboratory science be increased by further written and material standards in immunology?.- 13 Would the value of clinical laboratory science be increased by further written and material standards in haematology?.- 14 Would the value of clinical laboratory science be increased by further written and material standards in clinical chemistry?.- 15 Would the value of clinical laboratory science be increased by further written and material standards in toxicology?.- 4 Future Eccls Involvement.- 16 Future ECCLS involvement as seen by industry.- 17 Future ECCLS involvement as seen by health agencies.- 18 Future ECCLS involvement as seen by professional societies.

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Book SynopsisThis proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.Table of ContentsTECHNIQUES FOR BIOMARKER DEVELOPMENT.- Chapter 1. Reducing Uncertainties In Live Monitoring Of Radiation In Wildlife; T. Cresswell.- Chapter 2. Synchrotron Light Facilities And Applications In Life Sciences; V.M. Tsakanov.- Chapter 3. Elemental Imaging In Biology Using Synchrotron X-Ray Fluorescence Microscopy; K. Brown.-LOW-DOSE EFFECT MECHANISMS.- Chapter 4. Modelling Direct And Indirect Effects Of Radiation: Experimental, Clinical And Environmental Implications; S.C. Brueningk, G.P. Powathil.- Chapter 5. Immune Networks In The Context Of Low Dose Ionizing Radiation; D. Schaue et al.- Chapter 6. Learning From Nato Biomarker Research For Humans; A. Giovannetti et al.- BIOMARKERS FOR RISK EVALUATION.- Chapter 7. Exosomes As Radiation Biomarkers; K.K. Jella.- Chapter 8. Monitoring Very Low Dose Radiation Damage In Dna Using “Field-Friendly” Biomarkers; K. Rothkamm, S. Burdak-Rothkamm.- Chapter 9. The Development Of Bio-Assays Based On Non-Targeted Effects Of Radiation; A Potential Worm-Hole Into Ecosystem Level Biomarkers; C. Mothersill. BIOMARKERS IN WILDLIFE.- Chapter 10. Birds As Bioindicators Of Radioactive Contamination And Its Effects; A. Bonisoli-Alquati.- Chapter 11. Amphibians In Field Radioecology: A Review And Perspective; G. Orizaola.- Chapter 12. Measuring Adaptive Responses Following Chronic And Low Dose Exposure In Amphibians; M. Audette-Stuart et al.- Chapter 13. Are There Ecosystem-Relevant Endpoints For Measuring Radiation Impacts?; C. Bradshaw.-Chapter 14. Biomarkers And Ecological Indicators For Environmental Radioactivity In Invertebrates; K. Raines et al.- BIOMARKER USE AND RESPONSES.- Chapter 15. Biomarkers Of Radiation And Risk Assessment By Ionizing Radiation, Countermeasures For Radiation Protection Of Environment, Workers And Public; L. Qafmolla.- Chapter 16. Application Of The International System Of Radiation Protection In Fit-For-Purpose Assessment Of Impacts; T.L. Yankovich.- Chapter 17. Practicalities Of Mainstreaming Biomarker Use – A Canadian Perspective; S. Mihok, M. McKee.- Index.

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Book SynopsisThe term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.Table of ContentsWhat is epigenomics?.- Methods and applications of epigenomics.- The structure of chromatin.- DNA methylation.- The histone code.- Chromatin modifiers.- Chromatin remodelers and organizers.- Embryogenesis and cellular differentiation.- Population epigenomics and aging.- Cancer epigenomics.- Neuroepigenetics.- Epigenomics of immune function.- Nutritional epigenomics.

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Book SynopsisThis book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been demonstrated, and possible medical applications identified. Numerous clinical projects have now been undertaken, yielding startling results. Despite this, molecular hydrogen medicine remains underappreciated among the medical community at large. The author aims to rectify this situation by fairly but critically evaluating the potential clinical benefits based on the latest scientific research. In addition, the observed physiological effects of hydrogen gas are considered within the broad context of the evolution of life on earth, offering new perspectives and helping to place molecular hydrogen medicine legitimately within the framework of life sciences. Written in an accessible manner, the book will be of value to students, researchers, clinicians, and the general public. Table of ContentsPart I What is Molecular Hydrogen Medicine?.- Chapter 1 The power of hydrogen molecules uncovered.- Chapter 2 Development of Molecular Hydrogen Medicine.- Chapter 3 From the front-line of research – Interviews.- Chapter 4 Physiological effects of the hydrogen molecule.- Chapter 5 Some fundamental properties of hydrogen and water.- Chapter 6 Functions of heavy water in living organisms.- Chapter 7 The future of Molecular Hydrogen Medicine.- Part II Tracing the History of Life and Hydrogen.- Chapter 8 The genesis of life in the world of hydrogen, Eons ago- Chapter 9 Drastic changes of living organisms in the oxygen age.- Chapter 10 Since the appearance of humans.

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Book SynopsisThis book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.Table of ContentsChapter 1. Cancer of the Skin:Type and Etiology.- Chapter 2. Therapeutic intervention in skin cancer: Future prospects.- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer.- Chapter 4. The Epidemiology of Skin Cancer Worldwide.- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer.- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer.- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy.- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era.- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy.- Chapter 10. Biomedical engineering in cancer diagnosis and therapy.- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology.- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy.- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-

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Book SynopsisThis book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.Table of ContentsChapter 1_Genomic Classification of Human Pathogens. –Chapter 2_Metagenomics of Human Microbiome. –Chapter 3_Genomic Landscape of Novel Coronavirus (2019-Ncov) Towards Better Diagnosis and Efficient Antiviral Therapies. –Chapter 4_Deciphering the Role of Epigenetic Reprogramming In Host-Pathogen Interactions. –Chapter 5_Applications of Next Generation Sequencing In Infectious Pathogens. –Chapter 6_Bioinformatics Applications in Human Pathogens. –Chapter 7_ Non-Coding RNA Profiling: Potential Application in Infectious Diseases. –Chapter 8_ Microarrays: A Road Map to Uncover Host Pathogen Interactions. –Chapter 9_RNA Sequencing as Strategy to Understand Pathogenesis. –Chapter 10_ Non-Coding RNA as Drug Target against Infectious Diseases. –Chapter 11_ Emerging Transcriptional Approach for Identification of Drug Targets in Human Pathogens. –Chapter 12_ Proteogenomics Applications in Human Pathogens.–Chapter 13_Proteomic Strategies for Understanding Host Pathogen Interactions.–Chapter 14_Antimicrobial and Therapeutic Peptides. –Chapter 15_ Structural Proteomics Guided Design of Antimicrobial Drugs and Vaccines. –Chapter 16_Mechanism of Action of Antimicrobial Agents against Clinically Important Pathogens: A Proteomic Approach. –Chapter 17_Application of Lipidomics in Understanding Host Pathogen Interaction. –Chapter 18_Metabolomics: Advances and Applications In Human Pathogens. –Chapter 19_Host-Pathogen Interactions: Nature Inspired Sialic Acid Based Biointerface Materials. –Chapter 20_Nanoparticles as Therapeutic Nanocargos Affecting Epigenome of Microbial Biofilms. –Chapter 21_Challenges and Prospects in Omics Approach to Pathogens

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Book SynopsisThis book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.Table of ContentsChapter 1_Biosensing: Material, methods and principle of detection.- Chapter 2_Biosensing applications in the development of medical devices.- Chapter 3_Theranostics: basic principles.- Chapter 4_Material and technique advancements in the development of theranostic products.- Chapter 5_Medical device development strategies.- Chapter 6_Research aspects for the development of medical devices.- Chapter 7_Biosensor-based commercialized point-of-care devices.- Chapter 8_Medical devices in clinical set up.- Chapter 9_Clinical validation of medical devices.- Chapter 10_Regulatory steps involved in the validation of medical devices.- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies.- Chapter 12_Opportunities and challenges in medical device development.- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic.

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Book SynopsisThis book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.Table of Contents1 Initial response at crime scenes and prioritization of efforts.- 2 Crime scene processing: documentation and evaluation.- 3 Crime Scene Searching: An Exploration of Forensic Evidence.- 4 Collection, Preservation and Packaging: Forensic Evidence Management.- 5 Paint, Soil and Glass Evidences: A Silent Witnesses.- 6 Questioned Document Examination: A Prevalent Dispute.- 7 Medicolegal Examination: A Guide to the Criminal Investigation System.- 8 Examination of Tampered Voice.

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Book SynopsisThis is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research. Table of ContentsPart 1 Introduction 1 Academic Medicine and the Social Determinants of Health Part 2 Background 2 Why should we publish papers? 3 Overcoming the initial barriers to publication and the role of mentors? 4 When should we start doing research and publishing papers? 5 Does research improve patient care? 6 The status of biomedical research in some developing countries? Part 3 How to plan a study? 7 How to think of a research question? 8 What are the types of study design? 9 How to calculate an adequate sample size? 10 Understanding medical biostatistics 11 Applying biostatistics in medical research 12 Writing the research proposal: the art and the science 13 Ethics in research Part 4 How to write an original research paper? 14 Who should be an Author? 15 How to write an Abstract? 16 How to choose a Title? 17 How to write the Introduction to a scientific paper? 18 How to do a Review of the Literature? 19 How to write Material(Patients) and Methods? 20 How to write Results? 21 How to write the Discussion ? 22 How to Cite other papers and add References? 23 How to add Illustrations? 24 How to check for Plagiarism? 25 How to improve language and syntax in medical writing? Part 5 How to write other journal articles? 26 How to write an Editorial 27 How to write a Letter to the Editor? 28 How to write a Case Report 29 Systematic, Scoping and Narrative Reviews Part 6 After the paper is written 30 To which journal should you submit your article 31 Publication algorithm 32 How to do a Peer Review? 33 How to handle Rejection? 34 Bibliometrics Part 7 What else you should know about publication? 35 Is medical publishing lucrative? 36 How to start a New Medical Journal? Part 8 How to project your work further? 37 How to present a Poster in a conference 38 How to give an Oral presentation? Part 9 Education, planning and execution 39 Bedside teaching in Developing Countries 40 E-learning in the developing world 41 Develop learning objectives and evaluations- Multiple choice questions/ Objective Structured Practical Examination 42 How to prepare a lecture? 43 The Why and How of Problem based learning 44 How to conduct a Journal Club? Part 10 Other topics 45 Medical records 46 Clinical Audit 47 Clinical Drug Trials 48 Ethics in Genetic Testing

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Book SynopsisThe second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.Table of Contents Application of clinical genomics in diagnosis and disease treatment Exosomes as novel biomarkers of disease Membrane Lipids: Implication for Diseases and Membrane Trafficking Human natural killer cells and their cytotoxic capacity Molecular genomic approaches for diagnosing and managing tuberculosis Exploring the origin of cancer with stem cell biology Therapeutic potential of skin stem cells in vitiligo Clinical applications of cancer stem cells Immuno therapeutic approaches for cancer treatment Future of uro-oncology Prostate Cancer: Circadian Gene Regulated Malignancy Role of adenosine pathway in cancer Immune modulation and VEGF Modulating tumour microenvironment in the treatment of cancer The endosymbiont role of mitochondria in cancer progression and therapy Interplay of cancer associated fibroblasts and tumour associated macrophages in metastasis Chimeric antigen receptor therapy : A cutting edge therapy for multiple myeloma The future therapies for heart failure Futuristic experimental studies on heart failure and ischemic heart diseases AGE-PAGE Stress in the pathophysiology of atherosclerosis and its treatment Genetics of Left Ventricular Dysfunction in Coronary Artery Disease Gene editing in liver disease Interrupting crystal to calculus conversion : The future of renal stone research Preclinical models of intimal hyperplastic and restenosis for the development of novel therapies Nanoparticles in counteracting multidrug resistant bacterial Rapid eye movement sleep and dream sleep

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Book SynopsisThe book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.Table of Contentsa. Advances in Microbial Fermentation and Fermented Food product for Health b. Application of Computational Intelligence Techniques for in Prebiotics, Probiotics, and Nutraceuticals. c. Advances in Genetic Engineering technologies leading to the development of Prebiotics, Probiotics, and Nutraceuticals. d.The Commercial Perspective of Prebiotics, Probiotics, and Nutraceuticals components. e. Innovative technologies linked with the Prebiotics, Probiotics and associated elements. f. Benefits of Probiotics components and effects in immunological purposes. g. Emerging prospects and challenges of Probiotics and Prebiotics to human health. h. Wild edible plants the rich source of Nutraceuticals i. Probiotics Microbes and Biomedical Applications j. Marine Probiotics and Prebiotics for therapeutic application k. Recent Trends in Natural Medicines and Nutraceuticals Research l. Prospective of Probiotic, Prebiotic and Synbiotic for sustainable development of aquaculture

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Book SynopsisThis book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.Table of ContentsChapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.

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Book SynopsisThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.Table of ContentsChapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.- Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.- Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.- Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.- Chapter 15. Liver on a chip.- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.- Chapter 20. Lungs on a chip.- Chapter 21. Brain on a chip.- Chapter 22. Skin on a chip.- Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.- Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.

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Book SynopsisThis book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it.

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Book SynopsisThis book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.Table of Contents Understanding schizophrenia: introductory aspect of the mental disorder from various perspectives Genetic mutations and Alternative splicing in schizophrenia Understanding the Chemical Interactions in the Brain of Schizophrenia Patients A diagnostic perspective of schizophrenia: from past to present Is it schizophrenia or not? - Different Biological characterization A neurobiological aspect of schizophrenia and the relationship between neurological disorders: depression, anxiety, epilepsy Clinical treatment available for schizophrenia Insights into the neuro-pharmacological treatment of schizophrenia: past, present, and future Managing Schizophrenia – A Challenge for Physicians Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia Alternative Therapies used in Schizophrenia Different phases of schizophrenia patients: from the psychological perspective Stigmatizing Attitudes Towards Patients with Schizophrenia Among Medical Professionals and General Population Rehabilitation of Schizophrenia-Practical Interventions Consumption of Cannabis: A risk factor or a therapeutic agent for patients with Schizophrenia Medical Imaging and Schizophrenia: A Study on State-of-art Applications Schizophrenia and its Effect on Marital Satisfaction The mortality rate in schizophrenia

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Book SynopsisThis book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​Table of ContentsChapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity.- Chapter 2. Computation tools for prediction and analysis of genomic islands.- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study.- Chapter 4. Microbial genomic island discovery, visualization and analysis.- Chapter 5. Genomic islands in bacterial genome evolution and speciation.- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field.- Chapter 7. Genomic islands in nutritional fitness and adaptation.- Chapter 8. Genomic islands involved in iron uptake.- Chapter 9. Genomic islands in uropathogeneic E. coli.- Chapter 10. Genomic islands in Helicobacter species.- Chapter 11. Genomic islands in Staphylococcus.- Chapter 12. Genomic islands in Pseudomonas species.- Chapter 13. Genomic islands in Klebsiella pneumonia.- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae.- Chapter 15. Genomic islands in marine bacteria.- Chapter 16. Challenges in Eventing Horizontal Gene Transfer.- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands. ​

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Book SynopsisChapter 1. Factors beyond science in the development of urine biomarkers.- Chapter 2. Human Urine proteome a powerful source for clinical research.- Chapter 3. Comparison of Urinary Proteomes Among Three Animal Models.- Chapter 4. Urimem, a membrane that preserves urine for largescale biomarker study.- Chapter 5. Posttranslation Modifications of Human Urine.- Chapter 6. Application of Peptide Level and Posttranslational Modifications to Integrative Analyses in Proteomics.- Chapter 7. BiomarkerExtractor a deep learning-based model for text mining of urine biomarkers.- Chapter 8. Why are there proteins in urine.- Chapter 9. Changes in the urine proteome in an acute hypoxic rat model.- Chapter 10. Analysis of the active alterations in the urinary proteome of rats during the immunization process.- Chapter 11.Urine Glucose Levels Are Disordered Before Blood Glucose Level Increase Was Observed in Zucker Diabetic Fatty Rats.- Chapter 12. Comparison of urine proteomes from tumor-bearing mice with those from tumor-resected mice.- Chapter 13. Progress in the application of urine proteomics in cancer biomarker discovery.- Chapter 14. Urine proteome application in neurodegenerative diseases biomarker discovery.- Chapter 15. Urinary Proteome Biomarker Discovery in Autism.- Chapter 16. Progress of urinary proteome research in respiratory diseases.- Chapter 17. Changes of urinary proteome in acute and chronic pulmonary inflammation.- Chapter 18. Changes of urinary proteome in global cerebral ischemia-reperfusion injury.- Chapter 19. Urinary complement factor D is increased in primary malignant hypertension.- Chapter 20. The application of urinary proteomics in early detection of digestive diseases.- Chapter 21. Application of urine proteome in biomarker discovery for cardiovascular diseases.- Chapter 22. Comparison of urinary proteomes among three rat models of abdominal infection bacteria.- Chapter 23. Serial Changes of Urinary Proteome in Animal Models of Renal Diseases.- Chapter 24. Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury.- Chapter 25. Using one–to–many urine proteome comparisons to provide clues for fever of unknown origin.- Chapter 26. Exploring the overall effects of two traditional Chinese medicines on the body by urinary proteome.- Chapter 27. Effects of extrinsic factors on the urinary proteome.- Chapter 28. Take a deep breath.- Chapter 29. Tears: Potential Window for Monitoring Systemic Conditions.- Chapter 30. Changes of urine protiens in the rat e-cigarette model.- Chapter 31. Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT).

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Book SynopsisThe book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clinical trial design to acquire substantial evidence of efficacy and safety for candidate drugs in the target patient population. New and evolving topics such as artificial intelligence, machine and deep learning, drug repurposing approaches, and bioinformatics, are incorporated into the text as these features are becoming integrated into drug research and development. Additionally, it covers publication strategies, including literature search, manuscript preparation, data presentation, relevant discussion, editorial processes, elements of peer review, and bibliometrics. Finally, the book addresses grantsmanship, key strategies for building effective networks, mentorships, maintaining research integrity, and forging career advancement opportunities, including entrepreneurship.Table of ContentsPlease refer to the attachments tab.

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Book SynopsisThe book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular. Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.Table of ContentsChapter 1. Editorial: Biosystems.- 2. Potential of Biotechnology in cancer management.- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics.- 4. Applications of Nanomaterials in Medicine: Current status and future scope.- 5. Biomedical Applications of Nanofluids in Drug Delivery.

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Book SynopsisThis book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists in both clinical and basic medical research field. In this second edition of the book, five existing chapters have been updated. Five new chapters have been added to reflect the lasted developments in the related field of research.Table of ContentsChapter 1 Assessment of Itch and Pain in Animal Models and Human Subjects.- Chapter 2 Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse.- Chapter 3 Modulation of C-nociceptive Activities by Inputs from Myelinated Fibers.- Chapter 4 Pathophysiologic basis of the treatment of spontaneous pain.- Chapter 5 Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?.- Chapter 6 T cell and subsets in neuropathic pain.- Chapter 7 Astrocyte and microglia in chronic postsurgical pain.- Chapter 8 Dorsal spinal modulation of neuraxial opioids induced pruritus.- Chapter 9 Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch.- Chapter 10 Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.- Chapter 11 Pain Modulation and the Transition from Acute to Chronic Pain.- Chapter 12 Integrated, Team-Based Chronic Pain Management: Bridges from Theory and Research to High Quality Patient Care.- Chapter 13 Research progress of long-acting analgesics for the treatment of chronic pain.- Chapter 14 Update in the Treatment of Neuropathic Pain.- Chapter 15 Mechanisms of peripheral sensitization in neuropathic pain.

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Book SynopsisThis book reviews the etiology of major zoonotic diseases, their impact on human health, and control mechanisms for better management. It also examines factors influencing transmission, diagnosis, treatment, management, and prevention of zoonotic diseases caused by different human pathogens, including bacteria, viruses, fungi, protozoans, and parasites. It also introduces zoonoses with a wildlife reservoir and discusses different transmission modes, and factors that influence the epidemiology of zoonoses. It further discusses the holistic strategies for the cost-effective prevention and control of these zoonoses. Towards the end, the book also discusses infections that have spread from non-human primates to humans and strategies to improve disease control and elimination. This book is very useful for students, academicians, and researchers of veterinary sciences, veterinary medicine, and, veterinary public health.Table of Contents ) Chapter 1- ZOONOSES • Definition • Classification • Origin, emergence and re-emergence of zoonoses • Evolution of methods of managing/controlling zoonoses 2) Chapter 2-VIRAL ZOONOSES A) Human to human transmission (1-129) 1. Ebola 2. Marburg 3. SARS -1 4. MERS 5. SARS-2 6. Dengue 7. Chikungunya 8. Zika 9. Yellow Fever B) TRANSITION -TO ZOONOTIC VIRUSES 10. Influenza viruses- some basics a. Evolution- antigenic shift, host switching b. The Hong Kong (H5N1) virus 1997 c. Avian influenza d.H7N9 e. H1N1 f. H3N2 11. Nipah Chapter 3- Mosquito borne viruses 1. Japanese Encephalitis 2. St. Louis encephalitis 3. EEE 4. WEE 5. Australian Encephalitis 6. Ross River 7. WN-Kunjin 8. California, La Crosse 9. Rift Valley Fever 10. West Nile 11. O’ Nyong Nyong 12. Colorado Tick fever 13. Powassan virus 14. Kyasanur Forest Disease 15. Crimean Congo Haemorrhagic Fever VIRAL ZOONOSES (1-72) 1. Hanta 2. Rabies 3. RVF Chapter 4- BACTERIAL ZOONOSES 1. Anthrax 2. Anaplasmosis: A phagocytophilum 3. Bartonellosis • Bacillary angiomatosis (BA): B. henselae and B. quintana • Cat scratch fever/disease (CSF/CSD): B. henselae, B. clarridgeiae • Oroya Fever or Carrion’s disease: B. bacilliforms • Trench fever: B. quintana 4. Ehrlichiosis: E.chaffeensis; E. ewingii; E. canis, Neorickettsia sennetsu and recently described Panola mountain Ehrlichia species genetically closely related to E. ruminantium 5. Borreliosis 6. Lyme Disease: B. burgdorferi sensu lato 7. Southern Tick-Associated Rash Illness (STARI) or Masters’ disease: B. lonestari 8. Louse borne relapsing fever: B. recurrentis 9. Tularemia: Francisella tularensis 10. Q fever 11. Leptospirosis 12. Glanders 13. Mycobacteriosis -Part 1 Classical tuberculosis 14. Mycobacteriosis - Part 2 Zoonotic mycobacteriosis 15. Plague 16. Brucellosis Chapter 5- CHLAMYDIAL AND RICKETTSIAL ZOONOSES 1. Rocky Mountain Spotted fever 2. Indian tick typhus 3. African tick typhus 4. Scrub typhus-O. tsutsugamushi 5. Murine (Epidemic) typhus 6. Rickettsial pox – R. akari Chapter 6- MYCOTIC ZOONOSES Introduction Mycotoxicosis Aspergillosis Blastomycosis Candidiasis Coccidioidomycosis Cryptococcosis Dermatomycosis Histoplasmosis Mucoromycosis Rhinosporidiosis Sporotrichosis Chapter 7-Parasitic zoonoses Epidemiology of parasitic zoonoses A) PROTOZOAL ZOONOSES Trypanosomiasis Amoebiasis Babesiosis Chagas ’ disease Cryptosporidiosis Giardiasisis Leishmaniasis- Cutaneous & Visceral Sarcocystosis Toxoplasmosis B) HELMINTHIC ZOONOSES 1. Trematodiases Epidemiology of fish borne trematodiasis Clonorchiasis Dicroceliasis Echinostoma Fascioliasis Gastrodiscoidiasis Intestinal flukes- Fasciolopsis buski Heterophyiasis Opisthorchiasis Paragonimiasis-Lung fluke 2. Cestodiases Coenurosis Cysticercosis Diphyllobothriasis Dipylidiasis Dipylinum caninum Hydatidosis Taeniasis Rallietina spp. Sparagonosis Hymenolpiasis 3. Nematodiases Fish-borne nematodiasis Ancylostomiasis Anisakiasis Angiostrogylosis Capillariasis Dracunculiasis Gnathostomiasis Larva Migrans Schistosomiasis Trichinellosis Trichostrongylus Toxocariasis Chapter 9- Ectoparasites Louse borne diseases Tick paralysis Zoonotic ectoparasites Chapter 10-Wildlife as Reservoir of Zoonoses • Introduction • Opportunities of contact and transmission • Preventive measures • Preventing wildlife originated zoonoses Chapter 11-Non-human primates as reservoir Chapter 12-Rodents as Reservoir Chapter 13-Bat- natural reservoir of zoonotic viruses Chapter 14-Vectors as carrier of zoonoses ​

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