Immunology Books

Book SynopsisTable of ContentsSection 1: Immunologic Basis of Autoimmunity 1. Prelude: Historical introduction to autoimmunity and autoimmune disease 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 3. General Features of Autoimmune Diseases 4. Antigen Presentation, Dendritic Cells, and Autoimmunity 5. T cells and their subsets 6. Role of Th1 Th2 Th17 Cells in Autoimmunity 7. Tolerance and Autoimmunity: T Cells 8. Regulatory T Cells 9. B Cells and Autoimmunity 10. Immunological memory T cells 11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens 13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 14. Functional Effects of Autoantibodies 15. Cytokine Chemokines 16. Signaling Pathways in T and B Lymphocytes 17. HLA Genetics and Autoimmunity 18. Non HLA Genetics 19. AIRE related Autoimmunity 20. Immune Deficiencies and Autoimmunity 21. Infections and Autoimmunity 22. Noninfectious Environmental Agents and Autoimmunity 23. Sex, Pregnancy and Autoimmunity 24. Animal Models of Autoimmune Disease Section 2: Multisystem Diseases 25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma 27. Antiphospholipid Syndrome 28. Sjogren Syndrome 29. Rheumatoid Arthritis 30. Spondyloarthritis and Chronic Idiopathic Arthropathies 31. Myositis 32. Thyroid Disease 33. Type 1 Diabetes 34. Adrenalitis 35. Polyendocrine Syndromes 36. Gastritis and Pernicious Anemia 37. Hypophysitis 38. Hemolytic Anemia 39. Thrombocytopenic Purpura 40. Neutropenia 41. Aplastic Anemia 42. Clotting Disorders 43. Multiple Sclerosis 44. Peripheral Neuropathy 45. Myasthenia Gravis 46. Ocular Disease 47. Inner Ear Disease 48. Celiac Disease 49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease 50. Chronic Hepatitis 51. Primary Billiary Cirrhosis 52. Primary Sclerosing Cholangitis 53. Pancreatitis 54. Bullous Skin Diseases: Pemphigus and Pemphigoid 55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria 56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 57. Orchitis and Male Infertility 58. Oophoritis 59. Rheumatic Heart Disease 60. Myocarditis and Dilated Cardiomyopathy 61. Necrotizing Arteritis and Small Vessel Vasculitis 62. Large and Medium Vessel Vasculitides 63. Autoimmune Disorders of the Lung 64. Paraneoplastic Diseases 65. Antibody-Associated Neurological Diseases 66. Autoinflammatory and other Related Diseases Section 3: Diagnosis, Prevention, and Therapy 67. Autoantibody Assays, Testing, and Standardization 68. Prediction of Autoimmune Disease 69. Emerging Therapies for Autoimmune Diseases 70. Postlude

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Book SynopsisTable of Contents1. Cardiovascular pathology: guide to practice and training L. MAXIMILIAN BUJA, BIHONG ZHAO, ANA SEGURA, LAURA LELENWA, MICHELLE MCDONALD AND KATARZYNA MICHAUD 2. Anatomic considerations and examination of cardiovascular specimens (excluding devices) J.J. MALESZEWSKI, C.K. LAI, VIDHYA NAIR AND JOHN P. VEINOT 3. Age-related cardiovascular changes and diseases ATSUKO SEKI AND MICHAEL C. FISHBEIN 4. Fundamental principles in cardiovascular genetics MICHAEL A. SEIDMAN AND RICHARD NEAL MITCHELL 5. Pathophysiology of heart failure and an overview of therapies M.J. RANEK, J.M. BERTHIAUME, J.A. KIRK, R.C. LYON, F. SHEIKH, B.C. JENSEN, B.D. HOIT, J. BUTANY, M. TOLEND, V. RAO AND MONTE S. WILLIS 6. Congenital heart disease: pathology, natural history, and interventions GIULIA OTTAVIANI AND L. MAXIMILIAN BUJA 7. Vascular pathobiology atherosclerosis and large vessel disease QUINN A. BONAFIGLIA, MICHELLE BENDECK AND AVRUM I. GOTLIEB 8. Diseases of small and medium-sized blood vessels JAMES R. STONE 9. Aneurysms of the aorta: ascending, thoracic, and abdominal and their management RENU VIRMANI, YU SATO, ATSUSHI SAKAMOTO, MARIA E. ROMERO AND JAGDISH BUTANY 10. Myocardial ischemia and its complications GREGORY A. FISHBEIN, MICHAEL C. FISHBEIN, JESSICAWANG AND L. MAXIMILIAN BUJA 11. Pathology of sudden death, cardiac arrhythmias, and conduction system GAETANO THIENE, S. RIZZO AND C. BASSO 12. Toxins and the heart RYAN P. LAU AND MICHAEL C. FISHBEIN 13. Myocarditis MICHAEL A. SEIDMAN AND BRUCE MCMANUS 14. Cardiomyopathies GIULIA D’AMATI AND C. GIORDANO 15. The pericardium and its diseases SUSAN M. ARMSTRONG, P. THAVENDIRANATHAN AND J. BUTANY 16. Valvular heart disease PRADEEP VAIDEESWAR, JAGDISH BUTANY AND SARANYA SINGARAVEL 17. Cardiac valve replacement and related interventions J. BUTANY AND F.J. SCHOEN 18. The pathology of cardiovascular interventions and devices for coronary artery disease, vascular disease, heart failure, and arrhythmias L. MAXIMILIAN BUJA AND FRED J. SCHOEN 19. Tumors of the cardiovascular system, heart, and blood vessels MARIA E. ROMERO, YU SATO, MASAYUKI MORI AND RENU VIRMANI 20. Pathology of cardiac transplantation E. RENE RODRIGUEZ, CELESTE SANTOS-MARTINS AND CARMELA D. TAN 21. Basic pathobiology of cell-based therapies and cardiac regenerative medicine L. MAXIMILIAN BUJA AND RICHARD N. MITCHELL 22. Forensic aspects of cardiovascular pathology BARBARA SAMPSONA, J. HAMMERS AND MICHELLE STRAMA

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Book SynopsisTrade ReviewDoody's Core Titles® 2022 "This book covers diagnosis and management of allergic diseases with emphasis on new therapies. Primary care providers and other specialists who care for allergic patients will find this collection a valuable reference book." ©Doody's Review Service, 2022, Massoud Mahmoudi, DO, PhD (University of California San Francisco)Table of ContentsTentative: 1 Introduction to Mechanisms of Allergic Disease 2 Origins of Allergic Disease 3 Epidemiology of Allergic Disease 4 Indoor and Outdoor Allergens and Pollutants 5 Principles of Allergy Diagnosis 6 Allergen-Specific Immunotherapy 7 Asthma 8 Allergic Rhinitis and Conjunctivitis 9 Drug Allergy 10 Urticaria and Angioedema Without Wheals 11 Atopic Dermatitis and Allergic Contact Dermatitis 12 Food Allergy and Gastrointestinal Syndromes 13 Anaphalaxis 14 Occupational Allergy 15 Insect Allergy

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Book SynopsisTable of Contents1. Introduction Part 1: Mechanisms of Autoimmunity induction by infectious agents and vaccination 2. Molecular Mimicry and Autoimmunity 3. Epitope Spreading in Autoimmune Diseases 4. The immune neuroendocrine system, infections, and rheumatic diseases 5. CD5-Expressing B-1 Cells and Infection 6. Lymphocytes and Infection in Autoimmune Diseases 7. Endothelial Cell Autoreactivity and Infection 8. Microbiota and Autoimmunity 9. Infection, Autoimmunity, and Vitamin D 10. Seasonality and Autoimmunity 11. The Protective Role of Helminths in Autoimmunity 12. Vaccination and Autoimmunity 13. BCG Vaccination 14. Opportunistic Infections and Autoimmune Diseases 15. Can Antibiotics Cure Autoimmune Diseases? Part 2: Viruses and Autoimmunity 16. Anti-Viral Therapy, Epstein–Barr Virus, Autoimmunity, and Chaos (The Butterfly Effect) 17. Roles for Cytomegalovirus in Infection, Inflammation, and Autoimmunity 18. Hepatitis C and Mixed Cryoglobulinemia: An Update 19. HIV Spectrum and Autoimmune Diseases 20. Parvovirus Infection and Its Association with Autoimmune Diseases 21. Human T-lymphotropic Virus Type 1 and Rheumatic Diseases: A Link Between Infection and Autoimmunity 22. Sjögren’s Syndrome: Role of Viruses and Viral-Like Sequences 23. Viral Infection and Heart Disease: Autoimmune Mechanisms 24. Celiac Disease and Rotavirus Infection 25. Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity Part 3: Bacteria and Autoimmunity 26. Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease 27. Helicobacter pylori Infection and Gastric Autoimmunity: Coincidence or a Cause and Effect Relationship? 28. Multiple Sclerosis and Creutzfeldt–Jakob Disease are Autoimmune Diseases Probably Caused by Exposure to the Nasal Microbe Acinetobacter 29. Infection and Autoimmunity in Antibiotic-Refractory Lyme Arthritis 30. Streptococcus Pneumoniae and Autoimmunity: A Systematic Review of the Literature: How Pneumococcal Infection Might Be Related to Rheumatic Diseases 31. Mycobacteria and Autoimmunity 32. Mycobacterium avium Subspecies Paratuberculosis and Human Disease: Bridging Infection and Autoimmunity 33. Leprosy and Autoimmunity Part 4: Parasites and autoimmunity 34. Parasitic Infection and Autoimmunity 35. Toxoplasma and Autoimmunity 36. Malaria and Systemic Lupus Erythematosus: Complex Interactions and Reciprocal Influences Part 5: Autoimmune diseases and infections 37. Anti-Saccharomyces cerevisiae Antibodies Autoimmune Diseases 38. The Infectious Origin of the Anti-Phospholipid Syndrome 39. Infections and Systemic Lupus Erythematosus 40. Infections and Idiopathic Inflammatory Myopathies 41. Rheumatoid Arthritis and Infections: More Than an Association? 42. Infection and Systemic Sclerosis 43. Infection and Spondyloarthropathies 44. Infection and Behçet Disease 45. Vasculitides and Hepatitis C Infection 46. The Role of Infection in Inflammatory Bowel Disease: Initiation, Exacerbation and Protection 47. Post-Infectious Arthritis and Reactive Arthritis 48. Infection and Autoimmune Liver Diseases 49. The Role of infection in Immune-mediated Thrombocytopenia 50. Viral Infections and Type 1 Diabetes 51. Infection and Autoimmune Thyroid Diseases 52. Pemphigus and Infection 53. Infections and Autoimmune Renal Diseases 54. Infections Associated with Retinal Autoimmunity 55. Oral Infections and Autoimmune Diseases 56. infection and Guillain–Barré Syndrome 57. Acute Disseminated Encephalomyelitis Part 6: COVID-19 and autoimmunity SARS-CoV-2 (COVID-19) and Autoimmunity 58. COVID-19 and autoimmunity 59. COVID-19 and autoantibodies 60. COVID-19 and vasculitis 61. COVID-19 vaccines and autoimmunity

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Book SynopsisAn introductory overview of the immunology of cancer including therapeutic approaches, this book will be an invaluable source for clinicians, researchers and students of immunology and molecular biology.Table of ContentsIntroduction. Immune Recognition of Cancer-Tumor Antigens. Processing and Presentation of Antigen for the Activation of Lymphocytes. Cellular Recognition of Tumors by T and NK Cells. Humoral Recognition of Cancer. Immunotherapy of Cancer. Tumor Evasion of Immune System.

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Book SynopsisRecent progress in fundamental tumor immunology has led to immunotherapy trials in patients with solid tumors and hematological malignancies. In the past, immunotherapy approaches were primarily based on enhancement of tumor immunity with cytokines and adjuvant therapy, without knowledge of relevant tumor antigens. The discovery of tumor antigens capable of eliciting immune responses has now resulted in the development of antigen-specific immunotherapy strategies. Vaccination with defined peptide epitopes, purified proteins, cell components, and whole cells expressing defined tumor antigens provides an opportunity to measure antigen-specific immune responses in vaccinated patients, and to correlate immunity with clinical outcome.Tumor Antigens Recognized by T Cells and Antibodies provides a comprehensive overview of the molecular nature of tumor antigens that can be recognized by antibodies, helper T lymphocytes and cytotoxic T lymphocytes. Novel strategies to enhance ineffectiTable of ContentsTumor Antigens Recognized by Antibodies. Human Tumor Antigens Recognized by Antibodies (SEREX). Antibodies to Tumor Oncoproteins in Cancer Patients. Antibody and CTL Responses to the NY-ESO Antigen. Tumor Antigens Recognized by CD4+ T Cells (predominantly TH1). Melanoma Antigens Recognized by CD4+ T Cells. Mouse Models in the Recognition of Tumor Antigens. Antigens of the MAGE Family Recognized by CD4+ T Cells. Tumor antigens Recognized by CD8 T Cells. Melanoma Antigens Recognized by CD8 T Cells. Squamous Cells and Adeno Cancer Antigens Recognized by T Cells. Heat/Shock Proteins and Tumor Antigens. The Wilms Tumor Antigens as CTL Target. Ex vivo and in situ Tetramer Analysis of CTL Responses to Tumors. Altered Peptide Ligands of Tumor T Cell Epitopes: Implications for More Effective Vaccine Therapy in Human Neoplasia.

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Book SynopsisCase Studies in Allergic Disorders is designed for undergraduate and graduate students in immunology, medical students, and resident physicians. It describes the basic cellular and molecular mechanisms involved in the pathogenesis of commonly occurring allergic diseases and introduces the rationale for targeted treatment of allergy. Replicating the successful approach of Case Studies in Immunology, the book presents mechanisms of hypersensitivity through a selection of clinical cases that reinforce and extend the basic science. The cases are largely drawn from the records of Children's Hospital Boston. Linking the discussion of pathogenesis to actual clinical presentation establishes important connections between the bench and bedside. The book can be used as either a stand-alone text or asa companion to Janeway's Immunobiology and The Immune System.Trade Review"...Clear, concise, insightful, and useful....[Case Studies in Allergic Disorders] is a genuinely stimulating read for the immunology enthusiast." -- Yale Journal of Biology and Medicine"The authors have succeeded in developing a volume that is useful for teaching immunologic concepts of allergic disease to undergraduate and graduate students, interns, and residents. Overall, Oettgen and Geha have done an admirable job constructing a case-based textbook that will be useful to a diverse audience." --The Quarterly Review of Biology "...Clear, concise, insightful, and useful....[Case Studies in Allergic Disorders] is a genuinely stimulating read for the immunology enthusiast." -- Yale Journal of Biology and Medicine"The authors have succeeded in developing a volume that is useful for teaching immunologic concepts of allergic disease to undergraduate and graduate students, interns, and residents. Overall, Oettgen and Geha have done an admirable job constructing a case-based textbook that will be useful to a diverse audience." --The Quarterly Review of BiologyTable of Contents1. Acute Systemic Anaphylaxis 2. Allergic Asthma 3. Allergic Rhinitis4. Allergic Diseases of the Eye 5. Atopic Dermatitis 6. Contact Sensitivity to Poison Ivy 7. Transfusion Reaction 8. Drug-induced Serum Sickness 9. Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked Disease (IPEX) 10. Hereditary Angioedema11. Urticaria 12. Food Allergy 13. Eosinophilic Esophagitis 14. Allergic Bronchopulmonary Aspergillosis 15. Hypersensitivity Pneumonitis and Occupational Lung Disease 16. Venom Hypersensitivity17. Hypereosinophilic Syndrome 18. Churg-Strauss Syndrome19. Aspirin-Exacerbated Respiratory Disease (AERD) 20. Mastocytosis

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Book SynopsisThis text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and allergic diseases,and offers unparalleled research from nearly 60 international contributors.Table of ContentsThe cells of the pulmonary immune response: overview of the pulmonary immune response, Laurent P. Nicod; antigen-presenting cells, Henk C. Hoogsteden, Hamida Hammad, and Bart N. Lambrecht; CD4 T lymphocytes in allergic asthma, Mark Larche and A.B. Kay; B-Cell differentiation and IgE synthesis, Hamida Hammad and Bart N. Lambrecht; immune functions of mast cells and basophils, Sarbjit S. Saini; immune functions of human eosinophils, Paul J. Coffer, Patricia M. R.E. Silva, Marco A. Martins, and Leo Koenderman; immune functions of airway epithelium, Sundeep S. Salvi and Stephen T. Holgate. Regulation processes in the pulmonary immune response: tolerance to inhaled antigen, Elizabeth R. Jarman, Gerard F. Hoyne and Jonathan R. Lamb; sensitization to inhaled allergen, Susan L. Prescott; polarization of T-helper cells, Martien L. Kapsenberg, Eddy A. Wierenga, Pawel Kalinski and Esther C. De Jong; CD28 and B7 superfamily members - costimulation and regulation of T-cell function, Anthony J. Coyle, Stephen Manning, and Jose-Carlos Gutierrez-Ramos; control of lymphocyte trafficking through the lung, Reinhard Pabst and Thomas Tschernig; neuroimmune interactions in the pathogenesis of allergic asthma, Armin Braun, Wolfgang A. Nockher, and Harald Renz. Integrated immunology of airway inflammation: immunopathology of atopic and nonatopic asthma, Marc Humbert, Sun Ying, and Douglas S. Robinson; immunology of eosinophilic airway inflammation - what the animal models teach us, Bart N. Lambrecht, Leonie S. Van Rijt, and Harmjan Kuipers; regulation of cellular traffic in the asthmatic lung, Clare M. Lloyd and Jose-Carlos Gutierrez-Ramos; cytokine regulation of bronchial hyperresponsiveness, Johan C. Kips and Romain A. Pauwels; immunological functions of inflammatory mediators, Domenico Spina, Clive Page, Anthony P. Sampson, and Zuzana Diamant; virally induced eosinophilic airway inflammation, Wieslawa Olszewska and Peter J.M. Openshaw; airway remodelling as the outcome of a chronic immu

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Book SynopsisA cross between a dictionary and an encyclopedia, Desk Reference for Hematology, Second Edition presents a concise yet thorough examination of hematology and its relationship with other systems and disorders. The 1500 alphabetically listed articles provide quick and easy access to expert information, the 150 tables put precise data at your fingertips, and the 100 figures are a visual tool that clarify the text. The book also includes 500 references on state-of-the-art guidelines and recent developments.See whatâs new in the Second Edition: Revised articles emphasizing genetics, physiology, pathological mechanisms Updated coverage of treatments for leukemia, lymphoma, coagulation, and thrombotic disorders Hundreds of completely new articles, new illustrations, and new explanatory diagrams as well as revised tables Completely revised, this edition covers hematopoiesis, red blood cells, granulocytes, lymphocytes, platelets and hemostasis where the respective physiology is described anemias, leukemias, lymphomas, auto-immune disorders, hemorrhagic disorders, and thrombosis where etiology, pathogenesis, diagnosis and treatment is described. The book includes coverage of blood groups and the practice of blood component therapy. The editor pays particular attention to recent developments in hematological molecular genetics and leukemogenesis. The information is cross-referenced with words highlighted in bold face within an article to indicate that further information on the subject is available under the emboldened heading. A separate table provides common abbreviations used widely throughout the text. Carefully designed for ease of use, the book provides speedy access to authoritative information on the scientific basis of blood disorders and their treatment.Table of ContentsContents are listed alphabetically by subject.

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Book SynopsisHandbook of Animal Models in Transplantation Research is a new surgical handbook that provides detailed information concerning the transplantation of a variety of tissues in experimental animals. The text provides a practical guide for experienced investigators to develop new surgical transplantation models for application in a laboratory setting. Each chapter gives consistent descriptions of the anatomical considerations, the surgical model, and potential applications of the procedure. The organ systems covered include the heart and/or lung, liver, small bowel, kidneys, and bone marrow. The species selected for representation of each experimental model is based upon the usefulness and frequency of the model for studies in transplantation research. This book is important for all experimental surgeons, transplantation biologists, and students of surgical research.Trade Review"This book is an excellent reference for anyone interested in transplant research...a good investment." -Susan Harper, SYNAPSE, 28(4), December 1995Table of ContentsIntroduction (L. Makowka, D.V. Cramer, and L. Podesta). Kidney Transplantation: Renal Transplantation in the Rat (M.H. Sayegh and E.L. Milford). Renal Transplantation in the Rabbit (W. Lopatin, H. Noguchi, and L. Makowka). Kidney Transplantation in Yucatan Miniature Swine (T. Howard, C.A. Cosenza, D.V. Cramer, and L. Makowka). Liver Transplantation: Liver Transplantation in Mice (S. Qian and J.J. Fung). Orthotopic Rat Liver Transplantation (M. Knoop, R. Steffen, D.V. Cramer, and L. Makowka). Liver Transplantation in the Dog (C.E. Broelsch, L. Stevens, and J.B. Piper). Liver Transplantation in the Pig (D. Kahn and R. Hickman). Liver Transplantation in Primates (O. Imventarza, H.L.R. Rilo, A. Oks, J.J. Fung, and T.E. Starzl). Transplantation of Hepatocytes (A.A. Demetriou, J. Rozga, and A.D. Moscioni). Pancreas Transplantation: Whole Pancreas Transplantation in the Rat (M.J. Orloff and M.S. Orloff). Isolation of Pancreatic Islets for Transplantation Studies (C. Ricordi). Heart Transplantation: Heterotopic Heart Transplantation in Rodents (F.A. Chapman, D.V. Cramer, and L. Makowka). Heart, Lung, and Heart-Lung Transplantation in the Dog and the Pig (R. Saito and P. Waters). Heart Transplantation in Primates (D.K.C. Cooper, Y. Ye, and M. Niekrasz). Small Bowel and Multivisceral: Multivisceral Transplantation in the Rat (N. Murase and T.E. Starzl). Intestinal Transplantation in the Rat (D.R. Grant, R. Zhong, and R. Black). Multivisceral Transplantation in the Pig (L. Podesta, D.V. Cramer, and L. Makowka). Bone Marrow and Graft-Versus-Host Disease: Bone Marrow Transplantation and Graft-Versus-Host Disease in Mice (R. Korngold). Bone Marrow Transplantation in Dogs (H.J. Deeg and R. Storb). Bone Marrow Transplantation in the Pig (D.H. Sachs, P. Guzzetta, C.V. Smith, K. Nakajima, and A. Mixon). Xenotransplantation: The Use of Xenografts in Experimental Transplantation (D.V. Cramer and L. Makowka). Immunosuppressive Agents: The Use of Immunosuppressive Agents in Animal Models

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Book SynopsisAfter a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature.Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the readeTrade Review"… written by a number of prime experts in the field. … highly recommended to readers who are interested in the pharmacology of adenosine receptors." – Christa E. Muller, PharmaCenter Bonn, Germany in ChemMedChem, 3, 2008Table of ContentsIntroduction. Adenosine Receptor Pharmacology. Regulation of Macrophage Function by Adenosine Receptor Engagement. Anti-inflammatory Effects of Inosine. Regulation of Adenosine Receptor Expression in Inflammation. A2a Adenosine Receptors in Ischemia. Adenosine, Toll-like Receptors, and Angiogenesis. Adenosine Signaling and Lung Fibrosis. Adenosine and Endothelial Cell Function. Regulation of Peripheral Inflammation by Spinal Adenosine. Adenosine, Hypoxia, and Immunity. Adenosine Regulation of Dendritic Cell Function. A2b Receptors in Intestinal Epithelial Cells. Adenosine Receptors in Multiple Sclerosis. Adenosine Receptors in Infectious Disease. Adenosine, Tumors, and Immunity. Adenosine in Atherosclerosis. Adenosine in Neuroimmunomodulation.

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Book SynopsisThe Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained.The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduatTable of ContentsIdentification, Anaesthesia, and Euthanasia. Collection of Peripheral Blood Samples. Removal of Organs. Preparation of Cell Suspensions. Assessment of Cell Viability. Cell Cryopreservation. Oxidative Burst Assay Using Flow Cytometry. Cell Cytotoxicity. Lymphoblastic Transformation. Determination of Antibody-Producing Cells to a Specific Antigen. Mixed Lymphocyte Reaction (MLR). Intracellular Levels of Calcium Assay Using Flow Cytometry. Phenotyping of Blood Mononuclear Cells. Evaluation of Intracellular Level of Thiols. Apoptosis.OTIsAtlas of Immunology, Julius M. Cruse and Robert E. Lewis, University of Mississippi Medical Center, Jackson, Catalog no. 9489, January 1998, c. 350 pp., 7x10, ISBN: 0-8493-489-9, $69.95Illustrated Dictionary of Immunology, Julius M. Cruse and Robert E. Lewis, Jr., University of Mississippi, Jackson, Catalog no. 4557, 1995, 352 pp., 8.5x11, ISBN: 0-8493-4557-X, $75.00Handbook of Human Immunology, Mary S. Leffell, Noel R. Rose, and Albert D. Donnenberg, Catalog no. 134, April 1997, 656 pp., 6x9, ISBN: 0-8493-0134-3, $99.95

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Book SynopsisAcute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. For each test, applicable U.S. and international guidelines are also presented, and the formulation and selection of vehicles, dosages, and test animals are addressed.

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Book SynopsisThe Medicine on the Move series provides fully flexible access to subjects across the curriculum in a unique combination of print and mobile formats ideal for the busy medical student and junior doctor. No matter what your learning style, whether you are studying a subject for the first time or revisiting it during exam preparation, Medicine on the Move will give you the support you need.This innovative print and app package will help you to connect with the topics of microbiology and infectious diseases, to learn, understand, and enjoy them, and to cement your knowledge in preparation for exams and future clinical practice.By using this resource in print or as an app, you really will experience the opportunity to learn medicine on the move.Table of ContentsMicrobiology: Bacteria. Viruses. Fungi. Protozoa. Helminths. Antibiotics. Infectious Diseases: Respiratory infections. Gastrointestinal infections. Cardiovascular infections. Haematological infections and human immunodeficiency virus. Genitourinary infections. Nervous system infections. Skin infections. Bone and joint infections. Congenital, neonatal and childhood infections. History taking, septic screen and monitoring tests. Notifiable diseases. Self Assessment: Microbiology. Infectious diseases

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Book SynopsisThese procedures have, in turn, resulted in molecular probes that allow more definitive evaluation of the host response to its virus and to the tumor cell with which the virus or its precursors are associated.Table of Contents1 Comparative Immunology of Carcinogenesis by DNA Viruses.- I. Introduction.- II. Properties of Oncogenic DNA Viruses.- III. Oncogenic Potential of DNA Viruses in Vivo.- A. Papovaviruses.- B. Adenoviruses.- C. Herpesviruses.- IV. Oncogenic Potential of Defective Genomes.- A. Oncogenicity of Defective Viruses Produced by Exogenous Treatment.- B. Oncogenic Potential of Naturally Occurring Defective Genomes.- V. Neoplastic Transformation in Vitro by DNA Viruses.- A. Papovaviruses.- B. Adenoviruses.- C. Herpesviruses.- VI. Role of Virus Genome in Cell Transformation.- VII. Antigens Associated with DNA-Virus-Transformed Cells.- A. Intracellular Antigens.- B. Antigens Associated with the Surface of DNA-Virus-Transformed Cells.- VIII. Genetic Origin of DNA-Virus-Specified Antigens.- A. Origin of Intracellular Antigens.- B. Origin of Cell-Surface Antigens.- IX. Immune Response of the Host to DNA-Tumor-Virus-Induced Antigens.- A. Papovaviruses (SV40 and Polyoma).- B. Other Papovaviruses and Adenoviruses.- C. Herpesviruses.- X. Role of DNA-Virus-Induced Antigens in Neoplasia.- XI. Conclusions.- XII. References.- 2 Immunity to Leukemia, Lymphoma, and Fibrosarcoma in Cats: A Case for Immunosurveillance.- I. Introduction.- II. Immunosurveillance Hypothesis.- III. Feline Oncornaviruses.- IV. Feline Oncornavirus-Associated Cell Membrane Antigen.- V. Laboratory-Induced and Naturally Occurring Tumors of Cats.- A. Horizontal Transmission.- B. Immunosuppressive Potential of FeLV.- VI. Immune Response to Laboratory-Induced Tumors.- VII. Immune Response to Naturally Occurring Leukemia and Lymphoma.- VIII. Summary and Conclusions.- IX. References.- 3 Intracellular and Systemic Regulation of Biologically Distinguishable Endogenous Type C RNA Viruses of Mouse Cells.- I. Introduction.- II. Evidence for Three Classes of Biologically Distinguishable Endogenous Mouse Type C Viruses.- III. Differential Activation of Endogenous Viruses.- IV. A Gene Affecting Expression of Class I Virus.- V. A Gene Influencing the Magnitude of Release of Class III Endogenous Virus.- VI. Susceptibility to Exogenous Infection of Mouse Cells by Xenotropic Virus.- VII. High-Titered Neutralizing Activity Directed Against Xenotropic Virus in Normal Mouse Sera.- VIII. Activation of Type C Viruses from Lymphoid Cells Following Antigenic Stimulation.- IX. Biological Functions of Endogenous Type C Viruses.- X. References.- 4 Mammalian C-Type Oncornaviruses: Relationships between Viral Structural and Cell-Surface Antigens and Their Possible Significance in Immunological Defense Mechanisms.- I. Introduction.- II. Morphology of Mammalian C-Type Viruses.- III. Isolation and Physicochemical Characterization of Structural Polypeptides of Murine and Feline Viruses.- IV. Antigenic and Other Biological Properties of the Structural Polypeptides.- A. FLV.- B. FeLV.- V. Localization of the Virion Proteins and Glycoproteins in the Particle Structure.- VI. Viral Structural Antigens on the Cell Surface.- VII. Autogenous Immunity in Mice to Viral Structural Antigens.- VIII. Immunogenic Potency of Isolated Viral Proteins and Glycoproteins.- IX. Seroimmunotherapy of C-Type Virus Infections.- X. Concluding Remarks.- XI. References.- 5 Natural Immunity to Endogenous Oncornaviruses in Mice.- I. Introduction.- II. Widespread Occurrence of Natural Antibodies to MuLV.- III. Characterization of the Immune Response.- IV. Virus Specificity.- V. Autogenous Humoral Response to Virus-Induced Cell-Surface Antigens.- VI. Discussion.- VII. References.- 6 Biological and Structural Pleomorphism of the Oncornavirus Envelope Glycoprotein, gp70.- I. Introduction.- II. MuLV gp70 Is a Surface Component of Virus Particles.- III. MuLV gp70 Is a Surface Component of Infected Cells.- IV. MuLV gp70 Is a Component of the Surface of MuLV-Induced Lymphomas.- V. MuLV gp70 May Be Expressed in Normal Cells.- VI. Host Functions and Viral Genes.- VII. References.- 7 Autoimmunity, Oncornaviruses, and Lymphomagenesis.- I. Introduction.- II. Immunological Activation of C-Type Viruses.- A. Skin Graft Rejection Reactions.- B. Graft-Versus-Host Reactions.- III. Virus-Induced Autoimmunity and Lymphomagenesis.- IV. Discussion.- V. Summary.- VI. References.- 8 Natural Immunity to Murine Mammary Tumor Viruses.- I. Historical Review.- II. Immunofluorescence Studies on the Presence of Antibodies to MTV in Mouse Sera.- III. References.- 9 Immunogenicity and MuMTV-like Antigenicity of Human Breast Cancer Tissues.- I. Introduction.- II. Immunogenicity of Human Breast Cancer.- III. Immunological Measurements.- A. Autologous Breast Cancer Tissue.- B. Cross-Reactivity against MuMTV and Immunogenic Breast Cancer.- IV. Physicochemical Measurements.- A. SDS PAGE.- B. Native Proteins PAGE.- C. Molecular Hybridization.- V. Comments.- VI. References.- 10 Clinical Implications of Immunity to Oncogenic Viruses.- I. Introduction.- II. Etiology.- III. Prevention.- IV. Immunodiagnosis.- V. Therapy.- VI. Summary and Conclusions.- VII. References.

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Book SynopsisThe 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation.Table of ContentsSession I: Antibody V Genes.- The Formation of Antibody Variable Region Genes.- Discussion.- Session II: Antibody C Genes.- Organization and Reorganization of Constant Region Genes of Immunoglobulin Heavy Chains: Genetic Basis for Class Switching.- Discussion.- Session III: MHC Genes.- Molecular Analysis of MHC Antigens.- Discussion.- Session IV: MHC Antigens and T Cell Function.- Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigen.- Discussion.- Session V: Induction and Effector Functions of T Cells.- Induction and Effector Function of T Cells.- Discussion.- Session VI: T Cell Regulation.- T-Cell Growth Factor, A Lymphocytotropic Hormone.- Discussion.- Session VII: B Cell Differentiation.- Stimulation of a B Cell Subset by Anti-Immunoglobulin and T Cell-Derived Regulatory Molecules.- Discussion.- Session VIII: B Cell Regulation I.- The Degree of Clonal Elimination in Immunological Tolerance and Regulation of Heavy Chain Class.- Discussion.- Session IX: B Cell Regulation II.- Factors Determining Virgin and Postantigenic Repertoires of B Cell Population and Its Subsets.- Discussion.- Session X: Immune Networks.- Is the Network Theory Tautologic?.- Discussion.- List of Participants.

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Book SynopsisWits Guts Grit is inspired by the many questions acclaimed science writer and mother Jena Pincott explored about the natural forces that shape children’s minds and health. What if we identify the microbes that support stress resilience and find ways to expose our kids to them? What if we reintroduce the mineral magnesium, deficient in almost every child’s diet? Would it reduce anxiety and increase bounce back, as the science now suggests? What if memory and learning could improve measurably after eating certain foods—such as blueberries—high in plant chemicals called flavonols, or after certain forms of exercise? These and many more questions led Pincott to simple, all-natural “biohacks”—experiments inspired by current research and theory—complete with instructions on how to undertake them to help your own children strengthen their wits, guts, and grit. Explaining the science and her own experimentation with her two gung-ho daughters in a lively, accessible way, Pincott shows parents how the underlying ingredients of the traits we all want for our kids—resilience, focus, perseverance, working memory, and more—may be all around us in the natural world, ready to be harnessed.Trade Review"The brilliant Jena Pincott has done it again with Wits Guts Grit . A must read for every parent, teacher, psychologist, social worker, pediatrician and childcare provider. Five Stars." Louann Brizendine MD, neuropsychiatrist and author of the New York Times bestsellers The Female Brain and The Male Brain"If you are the kind of parent who reads the latest studies on resilience and achievement and wonder how they might really apply to your own kids, Jena Pincott's Wits Guts Grit is the book for you. Pincott breaks down the science in an entertaining and accessible wayand then offers a series of remarkable step-by-step "biohacks," or at-home experiments, to show parents how they can use the very world around them to help guide their kids grow into the most resilient, focused, and thoughtful version of themselves." Kayt Sukel, author of The Art of Risk: The New Science of Courage, Caution & Chance and This is Your Brain on Sex"Jena Pincott is a science writer who doesn't just ask questions and search for answers, she also applies the best of what she learns in her life. This book is the result of an evident passion for sharing her applied knowledge, and it will no doubt influence many lives for the better. It's a fantastic example of what I call 'science-help' in its truest form." David DiSalvo, author of What Makes Your Brain Happy and Why You Should Do the Opposite" Wits Guts Grit will be a sought-after addition for any public library parenting collection." Booklist"Accessibly informative, with thoughtful and thought-provoking observational commentary, Wits Guts Grit: All-Natural Biohacks for Raising Smart, Resilient Kids is fully and unreservedly recommended for both community and academic library Parenting instructional reference collections and supplemental studies lists." Midwest Book Review

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Book SynopsisLearn how to strengthen your immune system, for life. Our immune system is our body’s fortress — without it, we would be vulnerable to all sorts of infections and diseases. Yet misinformation about how to boost the immune system is everywhere. In Immune, Dr Servaas Bingé breaks through those myths, translating the latest scientific findings on immunity into clear advice with which you can optimise your lifestyle. Using no-nonsense language with a touch of humour and lots of creative thinking, Bingé takes us on a fascinating journey through our immune system. He explains how we become ill and how best to protect against it, providing superb guidance for the most important thing you can do — stay healthy.

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Book SynopsisPreface.- 1. From Genetics to Epigenetics: The Steps of a Path.- 2. Molecular basis of epigenetic mechanisms.- 3. Epigenetics and Endocrine Disruptors.- 4. New insights into the fetal programming hypothesis of the linkage between neurodevelopmental disorders and impaired neurogenesis.- 5. The Placenta and the development of human health.- 6. Epigenetics and cancer.- 7. Epigenetics in Autoimmune Diseases.- 8. Epigenetics and Systemic Vasculitis.- 9. Epigenetics and Allergic Diseases.- 10. The Role of Epigenetics in Autoinflammatory Diseases.- 11. Epigenetics and immune-mediated diseases.- 12. Epigenetics and Inherited Metabolic Disorders.- 13. Epigenetics and Psychiatric Diseases.- 14. The metabolomics revolution toward personalized medicine: the case of gestational diabetes.- 15. Epigenetics and Microbiome.- Index.

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Book SynopsisDer Band aus der Reihe „Module Innere Medizin“ ermöglicht Lernenden den Blick aufs Ganze. Systematisch stellen die Autoren das gesamte Organsystem Lunge und Atemwege dar: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Wegen seiner Praxisnähe eignet sich der Band nicht nur für Studierende, sondern auch für Ärzte in der pneumologischen Aus- und Weiterbildung.Trade Review“... Das Buch lohnt sich vor allem für den klinischen Abschnitt. Der Text ist gut verständlich geschrieben udn wird ergänzt durch zahlreiche anatomische Zeichnungen, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigsten Erkrankungen gut zusammen.” (in: AirMediPlus, Heft 4, 2015)“... Es ist kurz und praktisch zusammengefasst und man kann sich in kurzer Zeit einen guten Überblick verschaffen. ... Diagnostische Methoden werden sehr gut beschrieben und auch mit vielen Bildern verständlich gemacht. Die in Farbe hervorgehobenen Kästchen mit wichtigen Informationen sind sehr hilfreich und nicht zu häufig. Alles in allem wird man mit diesem Kurzlehrbuch gut für den Klinikalltag vorbereitet und kann damit auch die dazugehörigen Prüfungen bewältigen ...” (in: Fachschaft Medizin LMU München, fachschaft-medizin.de, Dezember 2015)“ ... ist das Buch wirklich sehr übersichtlich gegliedert und angenehm zu lesen ... Als Basic-Lehrbuch ist dieses Werk wirklich toll um sich kurz und bündig in das gesamte Spektrum der Pneumologie einzulesen und gut vorbereitet in die Famulatur oder ins KPJ zu starten ...” (Bösch, Dennis, in: Medizinische Universität Innsbruck, skalpell.at, 11. März 2015)"... sehr übersichtlich gegliedert und angenehm zu lesen. ... Als Basic-Lehrbuch ist dieses Werk wirklich toll um sich kurz und bündig in das gesamte Spektrum der Pneumologie einzulesen ..." (Katharina Greber, in: Der Medicus, Heft 1, 2015)“… gibt es viele anatomische Zeichnungen, die z.B. bei der Auskultation die Punkte zeigen, auf denen das Stethoskop aufgelegt werden sollte, um optimal abhören zu können. Also gibt es viele Röntgen- und CT-Bilder, welche schließlich zur Basisdiagnostik von Lungenerkrankungen gehören (neben der Anamnese und körperlichen Untersuchung) ...“ (in: Fachschaft Medizin Münster, fsmed-muenster.de, 2. Januar 2015)“... Das Buch ist laut Vorwort speziell für Medizinstudenten und junge Assistenten in Weiterbildung verfasst, jedoch auch Kollegen in Weiterbildung zu verschiedenen Facharzt- oder Spezialtiteln und erfahrene Fachärzte dürfen sich jederzeit eines Repetitoriums erfreuen, denn auch das kann das Buch bieten. ... Mit zahlreichen Tabellen, Graphiken und Abbildungen aus der Klinik wird man durch das Buch geführt. ... Der Lehrtext lässt sich flüssig lesen und ist verständlich nachzuvollziehen ...“ (Veronika Gebhardt, in: webcritics.de, 15. Januar 2015)“... übersichtlich gegliedert, mit Grafiken, Tabellen und Infoboxen ansprechend gestaltet und schön illustriert. ... Das Buch vermittelt zunächst alle grundlegenden Informationen zur Anatomie und Physiologie der Lunge, um diese wieder in Erinnerung zu rufen. ... Ätiologie und Pathophysiologie erklärt werden und zu denen jeweils die Diagnostik – gut illustriert - und die Therapie vorgestellt werden. ... als tolles Lehrbuch, das dieses Thema vor allem gut verständlich und sehr übersichtlich vermittelt ...“ (in: Veasyte, Wintersemester/2014-2015, S. 60 f.) “... Der Text ist gut verständlich geschrieben und wird ergänzt durch zahlreiche anatomische Zeichnungen,Schemata, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigesten Erkrankungen gut zusammen. Wichtige Inhalte sind nochmal in farbigen Abschnitten zusammengefasst oder in Tabellen wiedergegeben ...“ (in: FiMM Fachschaftsinitiative Medizin Mannheim FiMM-online.de, September 2014)“... Das Buch lohnt sich vor allem für den klinischen Abschnitt ... Der Text ist gut verständlich geschreiben[sic] und wird ergänzt durch zahlreiche anatomische Zeichnungen, Röntgen- und CT-Bilder und ähnlichen. Die Gliederung ist klar und fasst die wichtigesten Erkrankungen gut zusammen. ...wer schonmal unterwegs lernt (in Zug oder Stadtpark) und nicht immer das dicke Standardwerk Innere Medizin mit sich schleppen möchte, für den ist dieses Buch eine gute Alternative.“ (JohannaBS, in: Amazon.de, 15. September 2014)Table of Contents1. Anatomie und Physiologie der Lunge und Atemwege.- 2. Pneumologische Diagnostik.- 3. Epidemiologie pneumologischer Ekrankungen - Prävalenz, Risikofaktoren und Prävention.- 4. Obstruktive Atemwegs- und Lungenerkrankungen.- 5. Infektiöse Atemwegs- und Lungenerkrankungen.- 6. Diffuse Lungenparenchymerkrankungen.- 7. Lungengefäßerkrankungen.- 8.Lungen- und Bronchialtumoren.- 9. Pleuraerkrankungen.- 10. Atmungsstörungen und Atemregulationsstörungen.- 11. Tabakentwöhnung.

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Book SynopsisDieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.Table of ContentsA. Allgemeiner Teil.- I. Vorschriften, Anleitungen usw. über das Arbeiten und den Verkehr mit Krankheitserregern.- Bekanntmachung des Reichskanzlers, betr. Vorschriften über Krankheitserreger vom 21. 11. 1917 und 17. 12. 1921.- Verfügung des Reichspostministeriums betr. Postversand von Urinproben.- Anweisung des Bundesrats zur Bekämpfung der Cholera vom 9. 12. 1915.- Ratschläge des Kais. Gesundheitsamtes für Ärzte bei Typhus und Ruhr.- Anweisung für die tierärztliche Feststellung der Tuberkulose. Ausführung der bakteriol. Untersuchung. (Ausführungsvorschriften des Bundesrats zum V.S.G. vom 7. 12. 1911.- Vorschriften für die Nachprüfung des amtstierärztlichen Gutachtens bei Milzbrand, Rauschbrand, Wild- und Rinderseuche (Anlage zum preuß. Ausführungsges. zum V.S.G.).- Anweisung für den biologischen Pferdefleischnachweis mittels der Präzipitation (Anlage a zum deutschen Reichsfleischbeschaugesetze vom 3. 6. 1900).- Anleitung für die Ausführung der Wassermannschen Reaktion.- II. Entnahme und Verpackung von Untersuchungsmaterial.- 1. Blut.- 2. Eiter.- 3. Sputum.- 4. Rachen- und Nasensekret und Belag.- 5. Exsudate und Transsudate.- 6. Fäzes.- 7. Harn.- 8. Fleisch für die bakteriologische Fleischbeschau.- 9. Milch.- 10. Wasser.- III. Regeln für bakteriologische Arbeiten.- IV. Das bakteriologische Laboratorium.- 1. Der Arbeitsraum und Arbeitsplatz Laboratorium, Mobiliar, Arbeitstisch, Waseerzu- und -abfluß, Heiz- und Leuchtgas, elektrischer Strom usw., Abfälle..- 2. Das Mikroskop Ankauf, Mikroskop, Dunkelfeld, Mikroskopieren, Mikrometer.- 3. Sonstige Gebrauchsgegenstände für mikroskopische Arbeiten.- Objektträger, Deckgläser, Reinigung derselben, Pinzetten, Färbegestell, Platinnadel, Schätzung von Bakterienmengen, Scheren, Messer, Spatel, Präparatenkästen, Reagenzgläser, Flaschen usw., Meßkolben usw., Pipetten usw., Wagen, Zentrifugen, Luftpumpen..- 4. Sonstige Gebrauchsgegenstände für kulturelle Arbeiten.- Trocken- und Dampfsterilisatoren, sowie deren Einsätze, Petrischalen und sonstige Kulturgefäße, Brutschränke mit Wärmereglern, Kühlanlagen, Bakterienfiltration, Schüttelapparate, Trockenapparate..- 5. Sonstige Gebrauchsgegenstände für Tierversuche.- Versuchstiere, Vorrats- und Zuchtkäfige, Fütterung und Haltung, Züchtung und Ankauf, Operationshalter und -brett, Injektionsspritzen und Infusionsapparat, Inhalations- und Zerstäubungs-apparate, Sektionsbretter und -Instrumente..- B. Bakteriologischer Teil.- I. Die mikroskopische Untersuchung.- 1. Entnahme und Versand von Untersuchungsmaterial.- 2. Anreicherungsverfahren; Ausschleudern, Absetzen, Ausschütteln, Niederschlagen; Homogenisieren, Tuberkelbazillenanreicherung im Sputum, Verfahren mit Ammoniak nach Hammerl, mit Wasserstoffsuperoxyd nach Sachs-Mücke, Doppelmethode nach Ellermann und Erlandsen, Antiforminverfahren nach Uhlenhuth und Xylander, Modifikation von Hundeshagen, Schulte, Distaso, Loeffler; Ligroinverfahren nach Lange und Nitzsche, Abänderung nach Bernhardt, Niederschlagsmethode nach Ditthorn, Schultz, Fejér und Arpad. Mastixemulsionsverfahren nach Pfeiffer und Robitschek; Homogenisierung des Lungenauswurfs vom Rind, des Uterusausflusses vom Rind, der Milch, der Fäzes, tierischer Gewebe und des Blutes; Anreicherungsverfahren nach Hilgermann und Zitek; Anreicherung von Protozoen, Parasiteneiern und Milben.- 3. Das ungefärbte Präparat.- a) Das Deckglaspräparat.- b) Der hängende Tropfen.- c) Das einfache Bewegungspräparat.- d) Untersuchung im Dunkelfeld.- 4. Das gefärbte Deckglas- und Objektträgerpräparat.- a) Herstellung des Ausstriches und dicker Blutstropfen.- b) Trocknen und Fixieren.- c) Auflösung der Blutkörperchen, Fetttröpfchen und Granula.- d) Färben.- e) Entfärben.- f) Auflegen.- 5. Das Schnittpräparat.- a) Das Härten, Fixieren.- ?) Die Gefriermethode.- ?) Die Fixation; Härtung in Alkohol, Formalin, Sublimat, Müllerscher Flüssigkeit, Flemmingscher Lösung, Schnellhärtung nach Henke, Lubarsch, Scholz.- b) Die Entkalkung.- c) Die Paraffin- und Zelloidineinbettung.- d) Das Schneiden.- e) Das Färben des Schnitts.- 6. Die Färbeverfahren.- a) Farben. Anilinfarben, basische, saure und Neutralfarben, Färbeprozeß, Beizen usw.- b) Farblösungen, Beizen, Fixationsmittel usw.- Anhang: Härtungs-, Konservierungsflüssigkeiten usw.- c) Färbeverfahren für Ausstriche und Schnitte; Übersicht.- A. Universalmethoden, vorwiegend für Schnitte.- Nach Loeffler, mit Gentianaviolett, nach Kühne mit Karbolmethylenblau, nach Saathoff-Pappenheim mit Methylgrünpyronin, nach Nicolle mit Karbolthionin oder Methylenblau und Tannin, nach Pfeiffer mit Karbolfuchsin, Burrisches Tuscheverfahren, vitale Färbung..- B. Verfahren zur isolierten und Kontrastfärbung von Bakterien und Blutparasiten.- Orcein-Methylenblaufärbung nach Zieler, mit polychromem Methylenblau nach Fränkel, Doppelfärbung nach Manson, Romanowsky, Laveran, Methylenblau-Eosinfärbung für Ausstriche, mit eosinsaurem Methylenblau nach May- Grünwald, nach Ziemann, Verfahren nach Giemsa, Neißer, Sommerfeld, Pick — Jakobsohn, Malachitgrünfärbung nach Loeffler, Doppelfärbung nach Apel, Eosin — Azurfärbung nach Goodall, mit Fuchsin- und Patentblau nach Frosch, für Nekrosebazillen nach Jensen und Ernst, mit Kadmium-Methylenblau nach Quensel..- C. Gramsche Verfahren.- Gramsche Verfahren für Ausstriche und Schnitte, Abänderungen von Weigert — Kühne, mit Pikrinsäuremethyl — violett nach Claudius, mit Anilinwasser-Safranin nach Babes..- D. Kapselfärbung.- Nach Johne, Olt, Klett, Friedländer, Ribbert, Hoffmann, Boni, Tuscheverfahren nach Gins, v. Riemsdijk, für Schnittpräparate nach Friedländer..- E. Sporenfärbung.- Nach Koch, Hauser, Möller, Klein, Aujesky, Loeffler, Bunge, Waldmann, Weitzmann usw..- F. Geißelfärbung.- Nach Ficker, Loeffler, Zettnow, Peppier, Tribondeau, Fichet und Dubreuil, Bunge, Casares- Gil..- G. Färbung von Tuberkelbazillen und anderen säurefesten Bakterien.- I. Für Ausstrichpräparate. Übersicht über die Leistungsfähigkeit der gebräuchlichsten Verfahren; Verfahren nach Ziehl — Neelsen, Günther; gesetzliche Vorschriften, Verfahren nach Ehrlich, Hüllen- und Pikrinmethode nach Spengler, Verfahren nach Jötten-Haarmann, Bender, Kerssenboom, Schädel, Kayser, Ulrichs, Konrich, Schulte — Tigges, Herman, Kronberger, Czaplewski, Fränkel — Gabbet, Much, Weiß, mit Fettfarbstoffen, Leuchtbildverfahren nach Hoffmann und Koshverfahren nach Preis..- II. Für Schnittpräparate Verfahren nach Koch-Ehrlich, Schmorl, Baumgarten (für Leprabazillen)..- H. Färbung der Spirochäten.- Nachweis im Dunkelfeld, Verfahren nach Shamine, Ölze, Silberstein, Osmium-Giemsa-Tanninverfahren nach Hoff mann, Schnellfärbung mit Giemsalösung nach Hoffmann, Tuscheverfahren nach Burri, Silberimprägnation nach Fontana — Schneemann, Verfahren nach Becker, Schaudinn-Hoffmann, Oppenheim-Sachs, Levaditi — Hoffmann, Giemsa — Schmorl, Eisenalaunhämatoxylinfärbung nach Heidenhain, Verfahren nach Ruppert..- I. Färbung der Negrischen Körperchen Verfahren nach Lentz, Bohne, van Gieson..- K. Färbung von Protozoen.- Verfahren nach Nöller, Riegel, Oehler..- L. Kernfärbung.- Färbeverfahren mit Hämalaun, Bismarckbraun und Hämatoxylin nach Heidenhain..- M. Färberische Differenzierung von Bakterien.- Verfahren von Bezssonof..- N. Darstellung der Guarnierischen Körperchen.- II. Die Untersuchung in der Kultur.- 1. Die Sterilisierung.- Ausglühen, Trocken-, Dampf- und diskontinuierliche Sterilisation, chemische Sterilisation..- 2. Die Nährbodenbereitung.- a) Fertige Nährböden.- Gebrauchsfertige Nährböden, Trocken- und Ragitnährböden.- b) Herstellen der Nährböden.- ?) Das Wasser.- ?) Das Fleischwasser, Fleischextraktlösungen und Ersatzstoffe.- Harn, Knochengallerte, Hefewasser, Hefepepton usw., Abkochung von Blut, Molken und Nährsalzlösungen..- ?) Das Pepton.- Selbstbereitung von Pepton durch Pepsin- und Trypsinver-dauung, Hottingers und Knorrs Verdauungsbrühe, Nährstoff Heyden, Nutrose, Tropon, Nutroseersatz..- ?) Beurteilung der Ersatzpräparate für Fleischwasser und Pepton.- ?) Kochsalz.- ?) Sonstige Zusätze.- c) Reaktion, Neutralisieren und Alkalisieren der Nährböden.- Lackmus, Phenolphthalein, Wasserstoff ionenkonzentration, Komparator, optimale H-Ionenkonzentrationen für die einzelnen Bakterien..- d) Filtration und Klären der Nährböden.- e) Abfüllen und Aufbewahren der Nährböden.- Eingetrocknete und gebrauchte Nährböden wieder verwendungsfähig zu machen, Sterilisierung..- 3. Die Nährböden.- Übersicht über die besprochenen Nährböden..- a) Einfache Bouillon-, Gelatine- und Agarnährböden usw.- Nährbouillon, Hottingers Fleischbrühe, Knorrs Verdauungsbrühe, Flüssige Hefenährböden, Nährgelatine, Nähragar, Heyden-Agar, Ersatzmittel für Gelatine und Agar, besondere Zusätze zu Bouillon, Gelatine und Agar: Glyzerin, Zuckerarten usw..- b) Animalische Nährböden und Nährbodenzusätze.- 1. Nährböden mit Blut bzw. Blutfarbstoff.- 2. Blutserumnährböden, zusammengesetzte Serumnährböden und Serumersatz.- 3. Gekochte Fleisch- und Organscheiben.- 4. Sonstige animalische Nährböden und Nährbodenzusätze.- Galle, Ei, Milch..- c) Vegetabilische Nährböden und Nährbodenzusätze.- 1. Pilznährböden.- 2. Kartoffelnährböden.- 3. Sonstige vegetabilische Nährböden.- d) Besondere Nährböden für Typhus-, Paratyphus-, Koli- und Ruhrbazillen.- e) Besondere Nährböden für Choleravibrionen.- f) Besondere Nährböden für Diphtheriebazillen.- g) Besondere Nährböden für Tuberkel bazillen.- h) Besondere Nährböden für Gono-, Meningokokken usw.- i) Besondere Nährböden für Influenzabazillen.- k) Besondere Nährböden zur Unterdrückung von Proteus.- 1) Besondere Nährböden für azidophile Bakterien.- m) Besondere Nährböden für Eumyzeten.- n) Besondere Nährböden für Knöllchenbakterien.- o) Besondere Nährböden für Amöben.- 4. Die Züchtung der Mikroorganismen.- ?) Die Strichkultur.- ?) Die Stichkultur.- ?) Die Plattenkultur (das Kochsche Plattenverfahren).- Rollkultur usw., Ersatz durch fraktionierte Aussaat..- ?) Die Bestimmung der Keimmenge.- 1. Keimbestimmung durch das Plattenverfahren.- 2. Keimbestimmung durch das Zählkammerverfahren.- Anhang: Keimbestimmung in Vakzinen.- ?) Burrisches Tuscheverfahren, Einzell- oder Einkeimkultur.- ?) Die Hefereinzucht.- ?) Die Schüttelkultur.- ?) Die Bouillontropfenkultur.- ?) Die Anaerobenzüchtung.- a) Anaerobenzüchtung unter Beschränkung des Luftzutritts.- b) Anaerobenzüchtung nach der Buchnerschen Pyrogallol-Methode.- ?) Reagenzglaskultur.- ?) Plattenkultur.- ?) Kultur im hängenden Tropfen.- c) Anaerobenzüchtung unter Ersatz der Luft durch Wasserstoff.- d) Anaerobenzüchtung unter Zugabe tierischen Gewebes.- ?) Die Züchtung des Abortusbazillus Bang.- ?) Die Kultur in vivo.- ?) Das Fortzüchten der Bakterien.- ?) Die Konservierung von Sammlungs-Kulturen.- 5. Die Anreicherung der Bakterien zwecks Züchtung.- Im Harn, Wasser, Fleisch usw..- 6. Die Verfahren zur Feststellung von Lebensäußerungen der Bakterien, soweit sie zur Differentialdiagnose Verwendung finden.- ?) Sauerstoffbedürfnis.- ?) Schwefelwasserstoffprobe.- ?) Gas- und Gärprobe.- ?) Säure- und Baseprobe.- ?) Reduktions- und Oxydationsprobe.- ?) Indolprobe.- ?) Skatolprobe.- ?) Hämolysinprobe.- ?) Proteinochromprobe.- ?) Giftprobe.- ?) Farbstoffbildung.- ?) Lichtentwicklung.- ?) Resistenzprüfung.- ?) Enzymprobe.- ?) Sporenbildung der Hefen.- 7. Prüfung der Wirksamkeit chemischer Desinfektionsmittel.- A. Feststellung des entwicklungshemmenden (antiseptischen) Wertes.- B. Bestimmung des keimtötenden (desinfizierenden) Wertes.- a) Allgemeines.- b) Methodik.- 1. Das Seidenfadenverfahren nach Koch.- 2. Das Granatverfahren nach Krönig und Paul.- 3. Das Batistverfahren nach Hailer.- 4. Das Suspensionsverfahren nach Hueppe und v. Esmarch.- 5. Das Agarverfahren nach Bechhold und Ehrlich.- 6. Das Aufschwemmungsverfahren nach Bechhold und Ehrlich, sowie Reiter und Arndt.- 7. Die Rideal-Walkersche Methode.- 8. Die Lancet-Methode.- 9 The hygienic laboratory Phenolcoefficient method.- Die Berechnung der Wirksamkeit eines Desinfektionsmittels nach Phleps.- III. Der Tierversuch.- 1. Die Infektion.- Fesselung der Tiere, Narkose und Anästhesie, Enthaarung..- a) Die subkutane Impfung.- b) Die intramuskuläre Impfung.- c) Die intraperitoneale Impfung.- d) Die Impfung in die Blutbahn.- e) Die intrakutane Impfung.- f) Die perkutane Impfung.- g) Die intraokuläre Impfung.- h) Die intrastomachale und intraenterale Impfung.- i) Die intraviskale Impfung.- k) Die intraartikuläre Impfung.- l) Die subdurale Impfung.- m) Die intrapulmonäre Impfung.- n) Die intrapleurale Impfung.- 2. Die Behandlung der geimpften Tiere.- Blutabnahme, Tötung..- Virulenzsteigerung.- 3. Die Sektion.- IV. Besondere Untersuchungsmethoden für den Nachweis und die Unterscheidung der wichtigsten pathogenen und einiger anderer Mikroorganismen.- Fast sämtliche pathogenen und die wichtigsten saprophytischen Mikroorganismen in alphabetischer Reihenfolge..- C. Serologischer Teil.- I. Allgemeines.- Gewinnung und Konservierung der Seren, Blutkörperchen usw.- Überblick über die serologischen Verfahren.- II. Die Agglutination.- Bakterienaufschwemmung.- Serumdosen.- Orientierende Agglutinationsprobe.- Hauptversuch.- Schnellagglutination.- Klinische Verwendung der Agglutination.- Normalagglutinine.- Widalsche Probe (Typhus-Agglutination).- Absättigungsversuch nach Castellani.- Weil-Felixsche Reaktion bei Fleckfieber.- Agglutination beim infektiösen Verfohlen.- Agglutination (Agglomeration) von Trypanosomen.- Agglutination von Amöben.- Säureagglutination nach Michaelis.- III. Die Präzipitation.- Gewinnung von Präzipitations-Antigen und präzipitierenden Seren.- Titerbestimmung.- Spezifitätsbestimmung.- Bestimmung des Ursprungs von Blut (nach Uhlenhuth).- Biologischer Nachweis des Ursprungs von Fleisch, Fett und Milch.- Klinische Verwendung der Präzipitation.- Postmortale Verwendung der Präzipitation.- IV. Die Komplementbindung (Bordet-Gengousche Methode).- Rote Blutkörperchen S..- hämolytisches Serum S..- Komplement S..- Antigen S..- Antiserum S. 405..- Komplementbindung zum forensischen Blutnachweis.- Komplementbindung zum Nachweis des Ursprungs von Fleisch, anderen Nahrungs- und Genußmitteln.- Komplementbindung zur klinischen Diagnostik.- Wassermannsche Reaktion.- Abänderungen der Wassermannschen Reaktion.- Kälteverfahren nach Jacobsthal.- V. Die Konglutination und Hämagglutination (K-H-Reaktion.).- VI. Die Ausflockungsreaktion nach Sachs-Georgi.- VII. Ambozeptorbindungsreaktion nach Sachs- Georgi zum Nachweis von Fleischarten.- VIII. Die Lipoidbindungsreaktion nach Meinicke.- M. R. und D. M. bei Syphilis.- M. R. zur Eiweißdifferenzierung (Nachweis des Ursprungs von Blut, Fleisch usw.).- Die Meinickesche Reaktion bei Rotz.- Die Meinicksche Reaktion bei Beschälseuche.- Die Meinicksche Reaktion bei Lungenseuche.- IX. Die Trübungs- und Flockungsreaktion nach Dold.- X. Einige weitere Ausflockungsreaktionen bei Syphilis.- Nach Porges und Meier.- Nach Elias, Neubauer, Porges und Salomon.- Nach Herman und Perutz.- XI. Der Pfeiffersche und Metschnikoffsche Versuch.- XII. Das bakterizide Plattenverfahren.- XIII. Die Bestimmung des opsonischen Index.- XIV. Die Auswertung der Bakteriotropine.- XV. Der Nachweis von Diphtherietoxin im Patientenblut.- XVI. Der Nachweis von Antistaphylolysin.- XVII. Die Anaphylaxic.- XVIII. Die Allergie.- A. Die thermische Tuberkulinprobe.- B. Die Augenprobe (Konjunktival- oder Ophthalmoreaktion).- C. Die Reaktionen der äußeren Haut.- D. Kehllappenreaktion beim Geflügel.- XIX. Die Meiostagminreaktion.- XX. Die Antitrypsinreaktion.- XXI. Die Aggressine.- XXII. Die optische Methode und das Dialysierverfahren nach Abderhalden.- Anhang: Bezugsquellen von Reagenzien usw.- Druckfehlerverzeichnis und Ergänzungen.

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Book SynopsisRecent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus). This is the first book describing this emerging technology, which is receiving increasing attention for application in many different fields and biological systems - from human gene therapy to plant biotechnology.Table of Contents1. Intracellular and Intercellular Immunization.- 2. Current Methods for Genotypic and Phenotypic Knock-Outs in Mammalian Cells.- 3. Recombinant Antibodies for Ectopic Expression.- 4. Assembly and Folding of Antibodies in Natural and Artificial Environments.- 5. Protein Sequence Motifs Involved in Intracellular Trafficking.- 6. Intercellular Immunization.- 7. Intracellular Immunization.- 8. Gene Therapy and Research Applications of Intrabodies for Human Infectious Diseases.- 9. Plantibodies: Immunomodulation and Immunotherapeutic Potential.- 10. From Phage Libraries to Intracellular Immunization.- 11. Perspectives and Conclusions.

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Book SynopsisDrug resistance is a growing problem in today's society. Successful drugs are constantly being developed but there is always the risk that a small percent of the drug's target will be immune. These survivors can then lead to a new population, resistant to the action of this drug. New drugs are continuously under development to combat this problem, but these can, in turn, lead to new resistant populations. This problem is universal whether the target is to destroy a deadly virus, or an insect which is ravaging crop production. Development of new drugs is difficult and time consuming so it is of crucial importance that we understand the processes behind drug resistance. "Molecular Genetics of Drug Resistance" forms a vital and timely review of the genetic processes behind drug resistance. Starting with an overview of the area, each chapter focuses on a particular target with important sections on drug resistance in malaria and in cancer. Each chapter has been written by an acknowledged expert in the field and the careful work of the editors has ensured a consistent approach and presentation. Table of ContentsNatural selection and drug resistance; drug and pesticide resistance in fungi; viral drug resistance; herbicide resistance; drug resistance in insects; the mechanisms of drug action and resistance in malaria; multidrug resistance in mammalian cells mediated by members of the ATP-binding cassette superfamily; drug resistance in cancer chemotherapy; oxidative stress responses in mammalian cells; modulation and circumvention of drug resistance.

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Book SynopsisThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Trade Review"This outstanding volume represents a review of the various effects of biopharmaceuticals and nanomedicines on the immune system: immunotherapy, vaccines, and drug delivery; challenges and overcoming translational barriers stemming from immunotoxicity; strategies to designing more immunologically friendly formulations." —África González-Fernández, PhD, MD, Professor of Immunology and President of the Spanish Society of Immunology, University of Vigo, Spain "For those who are specialists, and for those interested in a broader understanding of biologics and nanomedicines, this is a superb book, with internationally accomplished contributors. It serves both as a reference and as a practical guide to the newest advances in these important fields. Highly recommended!"—Carl R. Alving, MD, Emeritus Senior Scientist, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA "A skillfully produced book that addresses an often-missed topic: immune aspects of biologicals and nanoscale therapeutics, with an emphasis on clinical relevance and applications." —Rajiv R. Mohan, PhD, Professor and Ruth M. Kraeuchi Missouri Endowed Chair Professor, University of Missouri, Columbia, USA"An indispensable masterpiece! It represents a rich source of information on interactions of biologics and nanodrugs with the immune system—all critical for medical applications. Volume 3, once again, achieves the series’ high standards."—László Rosivall, MD, PhD, DSc Med, Med habil., Széchenyi Prize Laureate and Professor, Faculty of Medicine, Semmelweis University, Budapest, Hungary "Hats off to Dr. Bawa for producing yet another impressive volume in terms of scope, timeliness, and relevance. With expert contributions from around the globe, this book addresses topics germane to researchers, clinicians, drug and biotherapeutic companies, regulators, policymakers, and patients." —Sara Brenner, MD, MPH, Associate Professor and Assistant Vice President, SUNY Polytechnic Institute, Albany, New York, USA"Marvelous! This timely book shows clearly that while an immune reaction to "nano-exposure" is usually unwanted, the same response also bears an immense potential." —Silke Krol, PhD, IRCCS Istituto Tumori "Giovanni Paolo II" and Fondazione IRCCS Istituto Neurologico "Carlo Besta," ItalyThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Table of ContentsList of Corresponding Authors, Foreword, My Life with Biologicals and Nanodrugs: A Twenty-Year Affair, 1. Current Immune Aspects of Biologics and Nanodrugs: An Overview, 2. Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox, 3. Immunotherapy and Vaccines, 4. Site-Specific Antibody Conjugation for ADC and Beyond, 5. Current Understanding of Interactions between Nanoparticles and the Immune System, 6. Auto-antibodies as Biomarkers for Disease Diagnosis, 7. The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers, 8. Anti-PEG Immunity Against PEGylated Therapeutics, 9. Complement Activation: Challenges to Nanomedicine Development, 10. Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation, 11. Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols, 12. Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions, 13. Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms, 14. Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities, 15. Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA, 16. Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism, 17. Immunogenicity Assessment for Therapeutic Protein Products, 18. Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products, 19. The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System, 20. Immunotherapy for Gliomas and Other Intracranial Malignancies, 21. Engineering Nanoparticles to Overcome Barriers to Immunotherapy, 22. Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications, 23. Silica Nanoparticles Effects on Hemostasis, 24. Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia, 25. Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin, 26. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines, 27. Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation, 28. Unwanted Immunogenicity: From Risk Assessment to Risk Management, 29. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials, 30. SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy, Index

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Book SynopsisVaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines.Trade Review“It can also serve as a useful reference for practicing physicians and veterinarians who would like to “boost” their knowledge of vaccines.” (Clinical Infectious Diseases, 6 October 2015)Table of ContentsContributors vii Preface ix 1 The history of vaccine development and the diseases vaccines prevent 1Martin G. Myers 2 The vaccine development pathway 33David W.C. Beasley 3 Control and eradication of human and animal diseases by vaccination 43Nigel Bourne and Gregg N. Milligan 4 Pathogenesis of infectious diseases and mechanisms of immunity 59Jere W. McBride and David H. Walker 5 The host immune response protective immunity and correlates of protection 73Gregg N. Milligan 6 Adjuvants: making vaccines immunogenic 93Gregg N. Milligan 7 Discovery and the basic science phase of vaccine development 109Gavin C. Bowick 8 Microbial-based and material-based vaccine delivery systems 127Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan 9 Licensed vaccines for humans 152Alan D.T. Barrett 10 Veterinary vaccines 181A. Paige Adams 11 Development of vaccines for microbial diseases 192Dennis W. Trent and David W.C. Beasley 12 The regulatory path to vaccine licensure 212Dennis W. Trent 13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232A. Paige Adams 14 Vaccine manufacturing 243Dirk E. Teuwen and Alan D.T. Barrett 15 Clinical evaluation of vaccines 260Richard E. Rupp and Bridget E. Hawkins 16 Vaccine recommendations and special populations 273Richard E. Rupp and Bridget E. Hawkins 17 Vaccine safety 287Dirk E. Teuwen and Alan D.T. Barrett 18 Understanding and measuring the dynamics of infectious disease transmission 304Christine M. Arcari 19 Vaccines from a global perspective 319Alan D.T. Barrett and Bridget E. Hawkins 20 Political ethical social and psychological aspects of vaccinology 335Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland Index 358

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Book SynopsisWith all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area.Table of ContentsContributors, vii Foreword, xii Preface, xiv About the companion website, xv 1 Tissues and organs of the immune system, 1Isam W. Nasr, Qiang Zeng, and Fadi G. Lakkis 2 Cells of the immune system, 25Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Tonya J. Webb, and Jonathan S. Bromberg 3 Soluble mediators in the immune system, 48Charles A. Su, William M. Baldwin III, and Robert L. Fairchild 4 Costimulatory molecules, 65Maria]Luisa Alegre and Anita S. Chong 5 Major histocompatibility complex, 85Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka, and Elaine F. Reed 6 T cells and the principles of immune responses, 103Jonathan S. Maltzman, Angus Thomson, and David M. Rothstein 7 Ischemia and reperfusion injury, 128Yuan Zhai, Yoichiro Uchida, Bibo Ke, Haofeng Ji, and Jerzy W. Kupiec]Weglinski 8 Immune responses to transplants, 142Denise J. Lo and Allan D. Kirk 9 Principles of hematopoietic cell transplantation, 164Sung Choi and Pavan Reddy 10 Therapeutic approaches to organ transplantation, 184Philip F. Halloran, Chatchai Kreepala, Gunilla Einecke, Alexandre Loupy, and Joana Sellarés 11 Organ]specific features in clinical transplantation, 217Roslyn B. Mannon 12 Transplant]related complications, 237Leonardo V. Riella and Anil Chandraker 13 Biomarkers of allograft rejection and tolerance, 259Choli Hartono, Thangamani Muthukumar, and Manikkam Suthanthiran 14 Emerging issues in transplantation, 280Rupert Oberhuber, Guangxiang Liu, Timm Heinbokel, and Stefan G. Tullius 15 New frontiers and new technologies, 297Haval Shirwan, Yiming Huang, Kadiyala Ravindra, and Suzanne T. Ildstad 16 Experimental models in discovery and translational studies, 316Andrew B. Adams, William H. Kitchens, and Kenneth A. Newell Index, 337

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Book SynopsisThis important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections.Table of ContentsIntroduction (M. Estes). Gastroenteritis Viruses: An Overview (R. Glass, et al.). Structural Studies on Gastroenteritis Viruses (B. Prasad, et al.). Early Events of Rotavirus Infection: The Search for the Receptor(s) (C. Arias, et al.). Rotavirus RNA Replication and Gene Expression (J. Patton). Pathogenesis of Rotavirus Gastroenteritis (M. Estes, et al.). Correlates of Protection Against Rotavirus Infection and Disease (P. Offit). Rotavirus Epidemiology and Surveillance (U. Desselberger, et al.). A Rotavirus Vaccine for Prevention of Severe Diarrhoea of Infants and Young Children: Development, Utilization and Withdrawal (A. Kapikian). The Molecular Biology of Human Caliciviruses (I. Clarke & P. Lambden). Molecular Epidemiology of Human Enteric Caliciviruses in The Netherlands (M. Koopmans, et al.). Molecular Biology of Astroviruses: Selected Highlights (S. Matsui, et al.). Molecular Epidemiology of Human Astroviruses (S. Monroe, et al.). Enteric Infections with Coronaviruses and Toroviruses (K. Holmes). Viruses Causing Diarrhoea in AIDS (R. Pollok). Treatment of Gestrointestinal Viruses (M. Farthing). Summing-Up (M. Estes). Index of Contributors. Subject Index.

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Book SynopsisDescribes the basic prerequisities for a fluorometric immunoassay: the antibody, the immunological technology, the fluorescent probe, and the instrument. Provides a profile of the clinical applications of the various assay technologies.Table of ContentsAntibodies as Analytical Reagents. Evolution of Immunoassays. Non-Isotopic Immunoassays. Photoluminescence Spectroscopy. Instruments in Fluorometric Immunoassays. Photoluminescent Probes. Fluorescence Immunoassays. Fluorometric Enzyme Immunoassays. Other Specific Binding Assays Using Fluorescence. Multiparametric Immunoassays. References. Index.

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Book SynopsisThis book provides an integrated approach to the study of immunology for people who seek a user-friendly', concise and up-to-date foundation text. There can be few subjects that so obviously demand such an approach. Immunology overlaps with the biological disciplines of biochemistry, cell biology, genetics, physiology, microbiology and parasitology relying on methods and concepts derived from these disciplines, and in turn contributing to them. After describing the components of the immune system, and explaining how they interact, the author goes on to discuss the many important applications of immunology in laboratory techniques and in medicine. In addition to this introductory' material, the book considers new, and likely future developments giving the reader a taste of the rapid rate of progress in this important field. The author's clear and concise text is supported by a wealth of illustrations (most in two-colour), self-assessment questions and a comprehensive index making thiTable of ContentsImmunity to Infection. Innate Immunity. The Cells of Adaptive Immunity. The Molecules of Adaptive Immunity. Collaboration and Escape. Antigens. Applications of Antigen Recognition. Maturation of the Adaptive Response. Regulation of the Immune Response. Disorders of Immunity. Self Assessment Questions (SAQs). Answers to SAQs. Optional Further Reading. Index. Acknowledgements.

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Book SynopsisHow good a representative is the immune system of a laboratory mouse? How may technical obstacles in one immunological model be bypassed by using another? How much progress has been made in the study of defense mechanisms in plants and animals of commercial importance? The answers to these and numerous other questions regarding the immunological similarities which can be detected across various orders, classes, phyla and kingdoms are found in this book. Provides pertinent information on the advances, opportunities and challenges in comparative work.Table of ContentsPlants (J. Metraux). Invertebrates (D. Millar & N. Ratcliffe). Fishes (M. Manning). Amphibians (J. Horton). Reptiles and Birds (R. Jurd). Mammals (R. Turner). Index.

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Book SynopsisA comprehensive history of the social and political aspects of vaccination in the United States, this work tells the story of how vaccination became a widely accepted public health measure over the course of the twentieth century. It examines the strategies that health officials have used to gain public acceptance of vaccines.Table of ContentsList of Illustrations Foreword by Daniel M. Fox Acknowledgments Introduction: Vaccination Politics and Law in American History 1. Between Persuasion and Compulsion: Vaccination at the Turn of the Twentieth Century 2. Science in a Democracy: Smallpox Vaccination in the Progressive Era and the 1920s 3. Diphtheria Immunization: The Power, and the Limits, of Persuasion 4. Hard Cores and Soft Spots: Selling the Polio Vaccine 5. Eradicationism and Its Discontents 6. Consent, Compulsion, and Compensation: Vaccination Programs in Crisis 7. Expansion and Backlash: Vaccination at the Turn of the Twenty-First Century Notes Archival Sources Index

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