Genetics (non-medical) Books

Book SynopsisThis book presents deliberations on molecular and genomic mechanisms underlying the interactions of crop plants to the abiotic stresses caused by heat, cold, drought, flooding, submergence, salinity, acidity, etc., important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomic-assisted breeding, and the recently emerging genome editing for developing resistant varieties in vegetable crops is imperative for addressing FHNEE (food, health, nutrition, energy, and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing has provided precise information regarding the genes conferring resistance useful for gene discovery, allele mining, and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to abiotic stresses.The nine chapters each dedicated to a vegetable crop or crop group in this volume elucidate on different types of abiotic stresses and their effects on and interaction with the crop; enumerate on the available genetic diversity with regard to abiotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; present brief on classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; depict the success stories of genetic engineering for developing abiotic stress-resistant crop varieties; discuss on molecular mapping of genes and QTLs underlying stress resistance and their marker-assisted introgression into elite varieties; enunciate on different genomics-aided techniques including genomic selection, allele mining, gene discovery, and gene pyramiding for developing adaptive crop varieties with higher quantity and quality of yields, and also elaborate some case studies on genome editing focusing on specific genes for generating abiotic stress-resistant cropsTable of ContentsSee attached Proposal Form, which includes ToC.

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Book SynopsisThis open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production. Table of ContentsChapter 1. IntroductionPart I. The Diversity of GenomicsChapter 2. Distributed and Concentrated Strategies in the Sequencing of the Yeast GenomeChapter 3. The Human Genome Project(s)Part II. Communities and Reference GenomesChapter 4. The Funnelling Effect of the Sanger InstituteChapter 5. The Pig Community and Their Reference GenomePart III. Contextualising and Enhancing Reference GenomesChapter 6. Making Reference Genomes Useful: AnnotationChapter 7. Improving and Going Beyond Reference GenomesChapter 8. Conclusion

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Book SynopsisThis book constitutes the refereed proceedings of the 19th Annual RECOMB Satellite Workshop on Comparative Genomics, RECOMB-CG which took place in La Jolla, USA, during May 20-21, 2022. The 18 full papers included in this book were carefully reviewed and selected from 28 submissions. The papers were organized in topical sections on evolution; phylogenetics; homology and reconciliation; genome rearrangements; metagenomics; and genomic sequencing. Table of ContentsEvolution.- On the Comparison of Bacteriophage Populations.- Syntenic Dimensions of Genomic Evolution.- Phylogenetics.- Fast and Accurate Branch Support Calculation for Distance-based Phylogenetic Placements.- The Sackin Index of Simplex Networks.- Phylogenetic Placement Problem: A Hyperbolic Embedding Approach.- Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account.- Homology and Reconciliation.- The Complexity of Finding Common Partitions of Genomes with Predefined Block Sizes.- Reconciliation with Segmental Duplication, Transfer, Loss and Gain.- Quantifying Hierarchical Conflicts in Homology Statements.- On Partial Gene Transfer and its Impact on Gene Tree Reconstruction.- Genome Rearrangements.- Sorting by k-Cuts on Signed Permutations.- A New Approach for the Reversal Distance with Indels and Moves in Intergenic Regions.- Chromothripsis Rearrangements Are Informed by 3D Genome Organization.- Metagenomics.- Using Computational Synthetic Biology Tools to Modulate Gene Expression within a Microbiome.- Metagenomics Binning of Long Reads Using Read-Overlap Graphs.- A Mixed Integer Linear Programming Algorithm for Plasmid Binning.- Genomic Sequencing.- Benchmarking Penalized Regression Methods in Machine Learning for Single Cell RNA Sequencing Data.- Deciphering the Tissue-speci c Regulatory Role of Intronless Genes Across Cancers.

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Book SynopsisOver the last few decades, various techniques have been developed to alter the properties of plants and animals. While the targeted transfer of recombinant DNA into crop plants remains a valuable tool to achieve a desirable breeding outcome, integration of transgenes into the host genome has been random, which in part, leads to reduced acceptance of GMOs by the general population in some parts of the world. Likewise, methods of induced mutagenesis, such as TILLING, have the disadvantage that many mutations are induced per plant, which has to be removed again by expensive backcrossing. Advances in genome sequencing have provided more and more information on differences between susceptible and resistant varieties, which can now be directly targeted and modified using CRISPR/Cas9 technology. By selecting specific gRNAs occurrence of off-target modifications are comparatively low. ZFNs and TALENs- based approaches required re-engineering a new set of assembled polypeptides for every new target site for each experiment. The difficulty in cloning and protein engineering prevented these tools from being broadly adopted by the scientific community. Compared to these technologies, designing the CRISPR toolbox is much simpler and more flexible. CRISPR/Cas9 is versatile, less expensive and highly efficient. It has become the most widely used technology for genome editing in many organisms.Since its inception as a powerful genome-editing tool in late 2012, this breakthrough technology has completely changed how science is performed. The first few chapters in this book introduce the basic concept, design and implementation of CRISPR/Cas9 for different plant systems. They are followed by in-depth discussions on the legal and bio-safety issues accompanying commercialization and patenting of this emerging technology. Lastly, this book covers emerging areas of new tools and potential applications. We believe readers, novice and expert alike, will benefit from this all-in-one resource on genome editing for crop improvement.Chapter 17 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of Contents S.No Tentative Chapter Title Author Details Genome engineering as a tool for enhancing crop traits: Lessons from CRISPR/Cas9 Tariq Shah and Aziz Khan* College of Agriculture, Guangxi University, Nanning, China Email: azizkhanturlandi@gmail.com Commercialization of CRISPR derived Crops: Current Status and future prospects Dr. Martin A Lema Universidad Nacional de Quilmes, Roque Sáenz Peña 180, B1876BXD Bernal, Buenos Aires, Argentina. Email: mlema@unq.edu.ar Targeted allele recombination for precise mapping in plant breeding Dr. Eyal Fridman Department of vegetables and field crops, Institute of Plant Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7505101, Israel Email: fridmane@volcani.agri.gov.il Hindex: 28 Applications of gene drive for weeds and pest management using CRISPR/CAS9 system in plants Dr. Kathleen Hefferon Food Science and Technology, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA Email: klh22@cornell.edu Hindex: 14 Genome editing by Ribonucleorotein based delivery of CAS9 system in plants Karina Morales, Michael J. Thomson Professor and HM Beachell Endowed Chair in International Rice Improvement Dept. of Soil and Crop Sciences, Texas A&M University / Texas A&M AgriLife Research 370 Olsen Blvd., 2474 TAMU, College Station, TX 77843-2474 Email: email: m.thomson@tamu.edu Hindex: 28 Virus mediated delivery of CRISPR/CAS9 system in plants Dr. Monika Bansal, Women scientist-A (completed) School of Agricultural biotechnology, Punjab Agricultural university, Ludhiana Dr. Shabir Hussain Wani Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, J&K, India Email:shabirhwani@skuastkashmir.ac.in Hindex: 24 Epigenetic and chromosomal Rearrangements in genome editing Neha Goel (Ph.D.) Genetics and Tree Improvement Forest Research Institute, Dehradun Email:goelneha6@gmail.con Dr. Shabir Hussain Wani Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, J&K, India Email:shabirhwani@skuastkashmir.ac.in Hindex: 24 Multiplexed genome editing in plants for improvement of various traits using CRISPR/CAS9 based system Dr. Goetz Hensel Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Plant Reproductive Biology Corrensstr. 3 D-06466 Seeland/OT Gatersleben GERMANY Email: hensel@ipk-gatersleben.de Hindex: 33 Application of CRISPR CAS9 for regulation of epigenetic traits in plants Abdullah Makhzoum Department of Biological Sciences and Biotechnology, Botswana International University of Science and Technology, Palapye, Botswana; Correspondenceabmakhzoum@gmail.com Hindex: 10 New Cas9 Variants and other nucleases broadening the scope of CRISPR Toolbox Dr. Goetz Hensel Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Plant Reproductive Biology Corrensstr. 3 D-06466 Seeland/OT Gatersleben GERMANY Email: hensel@ipk-gatersleben.de Hindex: 33 Transgene free genome editing in plants using CRISPR/CAS9 Dr. Niaz Ahmad Dr. Penny Hundleby Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK Email: penny.hundleby@jic.ac.uk Prof. Mehboob Rahman Group Leader Plant genomics & Mol. Breeding Lab, National Institute for Biotechnology & Genetic Engineering (NIBGE), PO Box 577, Jhang Road, Faisalabad, Pakistan. Email: mehboob_pbd@yahoo.com H index 23 Genome editing in plants for improvement of resistance in plants against fungal and viral pathogens Dr. Kathleen Hefferon Food Science and Technology, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA Email: klh22@cornell.edu H index 14 Characterization of gene edited crops via metabolomics. Dr. Muhammad Qudrat Ullah Farooqi School of Agriculture and Environment; Faculty of Science The University of Western Australia, Perth WA 6009 Australia Email: muhammadqudratullah.farooqi@uwa.edu.au Genome editing in plants for improvement of resistance in plants against bacterial pathogen Dr. Rajesh Mehrotra Birla Institute of Technology and Science (BITS-Pilani), Rahashthan, India Email: rmehrotra@pilani.bits-pilani.ac.in Dr. Purvalohan Bhalothia Email: purvalohan@gmail.com H index 16 Improvement of resistance in plants against Insect-pest using genome editing tools Dr Sandeep Kumar, Assistant Professor, Department of Zoology, KU SSJ Campus, Almora, Uttarakhand,India Email: sandeep.ento@gmail.com Comparing the efficiency of different delivery methods of CRISPR/CAS9 toolkits into plants Dr Ananda Sarkar National Institute of Plant Genome Research (NIPGR), Jawaharlal Nehru University Campus, Aruna Asaf Ali Marg, New Delhi, Delhi, 110067, India Email:aksarkar@nipgr.ac.in Hindex 17 Recent trends in targeting genome editing of tomato for abiotic stress tolerance Dr. P. Hima Kumari, Jawaharlal Nehru Technological University, Hyderabad, 500085 phimakumari@gmail.com Genome editing approaches for improving nitrogen use efficiency and deciphering mineral nutrient homeostasis Viswanathan Chinnusamy Principal Scientist & Head Division of Plant Physiology ICAR-Indian Agricultural Research Institute, New Delhi, India Email: viswa_iari@hotmail.com Hindex : 37 Recent advances and application of CRISPR base editors for improvement of various traits in crops Dr Seema Pradhan and Dr Ajay Parida, Director, Institute of Life Sciences, Bhubaneswar, India Email: drajayparida@gmail.com, director@ils.res.in Dr. Seema Pradhan Email: seemapradhan3@gmail.com CRISPR/Cas9-mediated targeted mutagenesis in medicinal plants Dr. Rohit Joshi Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India Email: joshirohit6@gmail.com H-index: 17 Biosafety issue related to genome editing in plants using CRISPR-Cas9 Dr. Ramesh Katam Department of Biological Sciences, Florida A&M University, Tallahassee, FL 32307, USA Email: ramesh.katam@gmail.com 22 IPR and regulatory issues in Genome editing in plants. Dimple Sharma Plant and Soil Science department Texas Tech University, USA Email: dimple.sharma@ttu.edu

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Book SynopsisAccess to food with enough calories and nutrients is a fundamental right of every human. The global population has exceeded 7.8 billion and is expected to pass 10 billion by 2055. Such rapid population increase presents a great challenge for food supply. More grain production is needed to provide basic calories for humans. Thus, it is crucial to produce 60-110% more food to fill the gap between food production and the demand of future generations.Meanwhile food nutritional values are of increasing interest to accommodate industrialized modern lives. The instability of food production caused by global climate change presents another great challenge. The global warming rate has become more rapid in recent decades, with more frequent extreme climate change including higher temperatures, drought, and floods. Our world faces various unprecedented scenarios such as rising temperatures, which causes melting glaciers and the resulting various biotic and abiotic stresses, ultimately leading to food scarcity. In these circumstances it is of utmost importance to examine the genetic basis and extensive utilization of germplasm to develop “climate resilient cultivars” through the application of plant breeding and biotechnological tools. Future crops must adapt to these new and unpredictable environments. Crop varieties resistant to biotic and abiotic stresses are also needed as plant disease, insects, drought, high- and low-temperature stresses are expected to be impacted by climate change. Thus, we need a food production system that can simultaneously satisfy societal demands and long-term development.Since the Green Revolution in the 1960s, farming has been heavily dependent on high input of nitrogen and pesticides. This leads to environmental pollution which is not sustainable in the long run. Therefore, a new breeding scheme is urgently needed to enable sustainable agriculture; including new strategies to develop varieties and crops that have high yield potential, high yield stability, and superior grain quality and nutrition while also using less consumption of water, fertilizer, and chemicals in light of environmental protection. While we face these challenges, we also have great opportunities, especially with flourishing developments in omics technologies. High-quality reference genomes are becoming available for a larger number of species, with some species having more than one reference genome. The genome-wide re-sequencing of diverse varieties enables the identification of core- and pan-genomes. An integration of omics data will enable a rapid and high-throughput identification of many genes simultaneously for a relevant trait. This will change our current research paradigm fundamentally from single gene analysis to pathway or network analysis. This will also expand our understanding of crop domestication and improvement. In addition, with the knowledge gained from omics data, in combination with new technologies like targeted gene editing, we can breed new varieties and crops for sustainable agriculture.Table of ContentsChapter. 1. The utilization of speed breeding and genome editing to achieve zero hungerChapter. 2. Multiomics approach for crop improvement under climate changeChapter. 3. The intervention of multi-omics approaches for developing abiotic stress resistance in cotton crops under climate changeChapter. 4. Big data revolution and machine learning to solve genetic mysteries in crop breedingChapter. 5. Applications of multi-omics approaches for food and nutritional securityChapter. 6. Applications of high throughput phenotypic phenomicsChapter. 7. Basil (Ocimum basilicum L.) : Botany, Genetic resource, Cultivation, Conservation, and Stress factorsChapter. 8. Multi-Omics Approaches for Breeding in Medicinal PlantsChapter. 9. Applications of some nanoparticles and responses of medicinal and aromatic plants under stress conditionsChapter. 10. Sustainable agriculture through technological innovationsChapter. 11. Sustainable Rice Production under Biotic and Abiotic Stress ChallengesChapter. 12. Emerging Techniques to Develop Biotic Stress Resistance in Fruits and VegetablesChapter. 13. Genome editing in crops to control insect pestsChapter. 14. CRISPR revolution in gene editing, targeting plant stress tolerance and physiologyChapter. 15. Genomics for Abiotic Stress Resistance in LegumesChapter. 16. Genetic and molecular factors modulating phosphorous use efficiency in plantsChapter. 17. Recent Trends in Genome Editing Technologies for Agricultural Crops ImprovementChapter. 18. Recent trends and applications of omics based knowledge to end global food hungerChapter. 19. Nutritional enhancement in horticultural crops by CRISPR/ Cas9: status and future prospectsChapter. 20. Physiological interventions of antioxidants in crop plants under multiple abiotic stressesChapter. 21. Proteomics and its scope to study salt stress tolerance in quinoaChapter. 22. Sustainable Cotton Production in Punjab: Failure and its Mitigating StrategiesChapter. 23. Biosafety and biosecurity in genetically modified crops

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Book SynopsisThis book is reflecting upon core theories in evolutionary biology – in a historical as well as contemporary context. It exposes the main areas of interest for discussion, but more importantly draws together hypotheses and future research directions. The Modern Synthesis (MS), sometimes referred to as Standard Evolutionary Theory (SET), in evolutionary biology has been well documented and discussed, but was also critically scrutinized over the last decade. Researchers from diverse disciplinary backgrounds have claimed that there is a need for an extension to that theory, and have called for an Extended Evolutionary Synthesis (EES). The book starts with an introductory chapter that summarizes the main points of the EES claim and indicates where those points receive treatment later in the book. This introduction to the subjects can either serve as an initiation for readers new to the debate, or as a guide for those looking to pursue particular lines of enquiry. The following chapters are organized around historical perspectives, theoretical and philosophical approaches and the use of specific biological models to inspect core ideas. Both empirical and theoretical contributions have been included. The majority of chapters are addressing various aspects of the EES position, and reflecting upon the MS. Some of the chapters take historical perspectives, analyzing various details of the MS and EES claims. Others offer theoretical and philosophical analyses of the debate, or take contemporary findings in biology and discuss those findings and their possible theoretical interpretations. All of the chapters draw upon actual biology to make their points. This book is written by practicing biologists and behavioral biologists, historians and philosophers - many of them working in interdisciplinary fields. It is a valuable resource for historians and philosophers of biology as well as for biologists. Chapters 8, 20, 22 and 33 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsSee attachments

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Book SynopsisThis open access book covers a century of research on wheat genetics and evolution, starting with the discovery in 1918 of the accurate number of chromosomes in wheat. We re-evaluate classical studies that are pillars of the current knowledge considering recent genomic data in the wheat group comprising 31 species from the genera Amblyopyrum, Aegilops, Triticum, and other more distant relatives. For these species, we describe morphology, ecogeographical distribution, phylogeny as well as cytogenetic and genomic features. For crops, we also address evolution under human selection, namely pre-domestication cultivation and domestication. We re-examine the genetic and archeological evidence of where, when, and how domestication occurred. We discuss unique aspects of genome evolution and maintenance under polyploidization, in natural and synthetic allopolyploids of the wheat group. Finally, we propose some thoughts on the future prospects of wheat improvement. As such, it can be of great interest to wheat researchers and breeders as well as to plant scientists and students interested in plant genetics, evolution, domestication, and polyploidy.Table of Contents

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Book SynopsisThe evolution of genome’s modification by genetic engineering was characterized by a major technological breakthrough with the discovery of CRISPR in 2012. A distinction is now made between first-generation biotechnologies developed in the 20th century and current second-generation biotechnologies, NGT or New Genomic Techniques, including genome editing. How do we consider these genomic modifications compared to those that occur spontaneously in nature? What are the applications of these techniques in the fields of plants, animals, and human health? What prospects in terms of development and independence for countries and at least what regulations are in force on the different continents?The book questions what GMOs are, genome editing products and the place of genomic transformations today and tomorrow in our societies. It tries to give some geostrategic and regulatory benchmarks on biotech products in order to better understand the current issues.Table of ContentsPreface Jean-Yves Le Déaut.- Introduction.- First part - Biotechnologies: landmarks and regulatory issues.- Chapter 1 - Biotechnologies: timeless, essential, and ubiquitous.- A broad definition.- Extensive fields of application.- The rise of biotechnology through genetic engineering.- Chapter 2 - Genomic modification, the very essence of biological life.- Incessant modifications of the genome in nature.- Mutagenesis and transgenesis, spontaneous phenomena.- Gene transfer between species.- Genomic selection in agriculture: a very ancient practice.- Conclusion.- Chapter 3 - Evolution of Genome Editing Techniques.- First-generation biotechnology.- Second-generation biotechnology.- Conclusion.- Chapter 4 - At the heart of a societal controversy.- When “crazy soy” meets Greenpeace (1996).- Tribulations of GMO maize crops in France (2007-2014).- A long list of European renunciations.- “Hidden GMOs”.- Conclusion.- Chapter 5 - GMOs: a regulatory concept.- Asilomar.- GMOs: a regulatory concept that differs depending on the country.- Disagreement between regulatory concept and scientific definition.- Conclusion.- Chapter 6 - Is the European regulation on GMOs still justified?.- Regulation, innovation, and the precautionary principle.- European regulations on GMOs.- Onerous and discouraging UE regulation.- UE regulation still relevant?.- Conclusion.- Chapter 7 - What regulation for NGT in the EU?.- The judgment of the EUCJ: context and consequences.- Opening a public debate in the EU.- Conclusion.- Chapter 8 - What regulations for NGT elsewhere in the world?.- American continent.- Asian Continent and Pacific Zone.- Other continents.- Conclusion.- Part two - GMOs in the world.- Chapter 9 - GMOs: medical and animal applications.- Laboratory animals to better understand and fight diseases.- Therapeutic advances.- Improving human nutrition.- Animal applications.- Conclusion.- Chapter 10 - Plant GMOs: agricultural applications.- First transgenic plants.- Characteristics of cultivated transgenic plants.- What are the cultivated transgenic plants?.- What need do these biotech crops meet?.- Respecting good agricultural practices to prevent foreseeable risks.- Is the coexistence of biotech and organic agriculture possible?.- Chapter 11 - Cultivated GMOs: what geopolitical perspective in 2023?.- First-generation agricultural GMOs: a rapid expansion.- What cultures develop?.- A Divided World.- A technology adopted by developing countries and poor farmers.- Commercialization today under the aegis of international consortia.- What to remember from 25 years of GMO crops?.- Conclusion.- Third part - New genomic techniques (NGT)What prospects? What issues?.- Chapter 12 - NGT: at the R&D stage.- Numerous R&D projects.- Patents mainly in the United States and China.- Chapter 13 - Second-generation medical biotechnologies: great hopes.- Therapeutic hopes.- Ongoing developments in medical research.- Two countries dominate.- Globalized, partnership-based medical research.- Conclusion.- Chapter 14 - NGT and animal applications.- Laboratory models.- Veterinary Medicine.- Animal wellbeing.- Livestock performance for food production.- And Europe?.- Conclusion.- Chapter 15 - Second-generation agricultural plant biotechnologies: state of the art.- Dynamism of research in plant breeding.- Global research.- Location by continent.- NGT agricultural plants in perspective.- Appendix: micro-organisms.- Conclusion.- General conclusion - The European Union at the crossroads of biotechnological paths.- Biotechnological innovation, an issue for agri-food and pharmaceutical sovereignty.- At the heart of scientific and academic reflection.- Worldwide recognition

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Book SynopsisSection I An Introduction to Biofilms and Omics.- Introduction to Microbial biofilms.- Microbial Biofilms and Resistome: Concept and Applications.- Fundamentals and Application of Omics in Microbiology.- Microbiomes and biofilms: Fundamentals and Translational Applications.- Section II Omics in Biofilm Research.- Genomic insights in Biofilm research.- Proteomics and their Applications in Biofilm Research.-  Transcriptomics in understanding the Biofilm Dynamics and inhibition.- Metabolomics approaches in understanding the biofilm and its inhibitors.- Metagenomics in understanding the microbial biofilms and Therapeutic Intervention.- Phenomics and microbial biofilms.- Comparative genomics in understanding microbial biofilms.- Lipidomics in understanding microbial biofilms.- Culturomics and biofilms.- Section III Omics as Diagnostic and Therapeutic tools.- Omics in the diagnosis/identification of biofilms.- Omics in Diagnosis and Therapeutics of Polymicrobial biofilms.- Systems biology/Computational systems biology and biofilm.- Synthetic biology and Biofilms.- Omics-based Therapeutics against Biofilm Mechanics.

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Book SynopsisChapter 1. Role of Nuclear Lamins in the Regulation of the Genome: Focus on Cardiolaminopathy.- Chapter 2. Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei.- Chapter 3. Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.- Chapter 4. Laminopathies and Cancers- Involvement of Lamins and Lamin-Chromatin Interactions.- Chapter 5. Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis- tous pour un et un pour tous.- Chapter 6. Changes in Chromatin Organization and  Mechanotransduction Mediated by Mutant Lamins in Laminopathies.- Chapter 7. ECM-Lamin Crosstalk in the Regulation of Genomic Stability.- Chapter 8. The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation?.- Chapter 9. The Role of Lamins in Genome Organization: A Modelling Perspective.- Chapter 10. The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies.- Chapter 11. Dynamic Post-Translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology.

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Book SynopsisAuf dieser DVD-ROM finden Sie die Grafiken und Fotos der 5. Auflage, die Sie als jpg-, PDF- oder PowerPoint Dateien für Ihre Vorlesungen nutzen können.Table of ContentsAbbildungen

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Book SynopsisIn kurzer und anschaulicher Weise gibt Thomas Binz einen Überblick über die biologische Sicherheit im Laborbereich. Die wichtigsten Elemente, wie die Zuteilung der Mikroorganismen zu Risikogruppen, die Bewertung der Risiken bei der Erzeugung von genetisch veränderten Mikroorganismen und die Elemente des Laboratoriums, die im Hinblick auf die biologische Sicherheit besonders relevant sind, werden unter Berücksichtigung der europäischen gesetzlichen Grundlagen dargestellt. Aufgrund des hohen Stellenwerts der Risikobewertung wird detailliert auf dieses Verfahren einschließlich anschaulicher Beispiele eingegangen. Das Buch soll nicht nur einen Überblick über die biologische Sicherheit geben, sondern auch zu ihrem Verständnis beitragen.Der AutorDr. Thomas Binz geht einer behördlichen Tätigkeit im Bereich Biologische Sicherheit nach (Bewilligungswesen, Abschätzung biologischer Risiken gentechnisch veränderter Organismen, nationale und internationale Rechtssetzung, Biowaffenkonvention). Er ist in verschiedenen nationalen und internationalen Ausbildungsprogrammen (Schweizerisches Biosafety Curriculum, Europäische Gesellschaft für Biosicherheit) eingebunden und unterrichtet im Rahmen des französischen 'Diplôme universitaire' für Biosicherheit der Universität Lille.Table of ContentsRisikobewertung.- Biosicherheitsstufe und Maßnahmen.- Biosicherung und Transport von infektiösem Material.

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Book SynopsisThis essential should serve as an introduction for a contemporary public discussion on genetic engineering. Genetic engineering affects us all in many areas and we must dare to think more colorful and further. In fact, the complete genetic material of viruses and bacteria can already be chemically produced and "brought to life". With genetic surgery, medicine is at a crossroads: do we want to treat hereditary diseases or "repair" them genetically? And the analysis of thousands of human genetic material reveals information that is related to complex diseases, but also to characteristics such as intelligence. How should we use this knowledge? The question is hardly whether we want genetic engineering, but rather how we use it.This Springer essential is a translation of the original German 1st edition essentials, Gentechnik by Röbbe Wünschiers, published by The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.Table of ContentsHow is the genetic material read and what does the information say?.- Which methods can be used to modify the genetic material and what are the goals?.- Who owns genetic information and what can be marketed and how?.- How does the environment affect the genetic material?.- Do we want a liberalization of genetic engineering as a civic science?

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Book SynopsisDNA ist das Material von Krimis, Archäologie und Vaterschaftsklagen. Spätestens seit Corona-PCR-Tests sind Nucleinsäuren im wahrsten Sinne des Wortes „in aller Munde“. Dieses Springer-essential beschäftigt sich damit, was man auch mit DNA machen kann. Meist sind diese Dinge ungewöhnlich, manchmal high-tech, hoffentlich lehrreich und eventuell sogar amüsant. Vielleicht ist dieser Band ja eine Anregung für Sie, DNA aus einer anderen Perspektive zu sehen.

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Book SynopsisDieses Buch ist ein wichtiges Manifest für das Verständnis der menschlichen Evolution und Variation im 21. Jahrhundert. Es leistet einen bedeutenden Beitrag zur aktuellen Diskussion über die Rasse. Klischees und Mythen über Rassen werden nicht nur von offenkundigen Rassisten zum Ausdruck gebracht. Auch gut meinende Menschen vertreten durch ihren kulturellen Erfahrungshorizont Ansichten, die nicht durch die moderne Humangenetik gestützt werden. Sogar der wissenschaftliche Rassismus greift zunehmend um sich und beeinflusst den öffentlichen Diskurs über Politik, Migration, Bildung, Sport und Intelligenz. Der Leser bekommt Argumente an die Hand, um dem entgegen zu treten. Adam Rutherford zeigt, dass die moderne Humangenetik ein mächtiger Verbündeter gegen Rassismus sein kann. Sie zeigt, wie Menschen tatsächlich sind, und nicht, wie sie von der Gesellschaft gesehen werden.Table of ContentsEine Bemerkung über die Sprache.- Vorwort zur Taschenbuchausgabe.- Einleitung.- Haut im Spiel.- Deine Vorfahren sind meine Vorfahren.- Black Power.- Weiße Substanz.- Zusammenfassung und Schluss.

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Book SynopsisWith CRISPR/Cas gene editing tools in hand, we are currently experiencing a new dimension in genetic engineering. But where should the journey lead? Should we treat diseases or better repair them genetically? Will the new genetic engineering, combined with modern reproductive biology, lead to designer babies? And: May we allow a liberalization of these techniques as citizen science? New methods can precisely alter the genetic material - and they leave no traces. This gene and genome surgery thrives on increasing knowledge about the mode of action of genes, those trait-giving regions in the genome. This knowledge is being applied in practice, particularly in the breeding of more resistant and higher-yielding crops. And what about us? The author shows that gene variants have long been associated not only with diseases, but also with nutritional preferences or intelligence. Therapeutic and optimization options are close at hand. What effect does the environment have on the expression of genetic material? Genes can be shaped during a person's lifetime by the environment, nutrition or experiences and thus passed on to their offspring in a modified form. So, does society have a new form of long-term responsibility for (epi)genetic integrity? In this vividly and comprehensibly written book, the author explains the state of genetic engineering without assuming too much prior knowledge and invites an open dialogue on this ambivalent topic. Get your own idea of the fascinating yet intimidating possibilities of genetic engineering. Where do you stand on the issue? With the help of this book, you have the chance to form a differentiated opinion. This book is a translation of the original German 1st edition Generation Gen-Schere by Röbbe Wünschiers, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text was subsequently revised by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Table of ContentsPreliminary thoughts.- What is genetic information? .- Breeding yesterday until today.- Read genetic material.- Edit genetic material.- Write genetic material.- Genes and society.- Rethink genetics, - And now ?.

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Book SynopsisThis book is written in a very simple and lucid manner so that everybody can read and understand it very easily. This book is useful for scientists, teachers, students, officers, diagnosticians and laboratory technicians as cell culture has become an essential and indispensable tool in many branches of life sciences and application of cell culture is getting increased exponentially day by day in various fields of biological and medical research arena. This book will provide detailed information on all the aspects of the cell culture starting from establishment of a cell culture laboratory, primary culture, secondary culture, media filtration, collection, preservation and dispatch of samples for diagnosis of viral diseases, cell line authentication and characterization, contamination and curing, cryopreservation of cells and revival of cells besides description on ELISA, SNT, virus titration etc. In my opinion, this book will be extremely useful to the persons who are directly and indirectly involved in cell culture work for various biological experiments. Finally, students and examinees can enrich their knowledge on cell culture from the book and can face any challenge easily and confidently. s on the latest developments on biotechnological approaches for fish disease diagnostic, infection and immunity of brood carps, cryoconservation of fishes, probiotics and nanotechnology in aquaculture are of paramount interest, in addition to information on prawn aquaculture, ornamental fish farming and trade. Information on various software and their application for exploratory data analysis and data mining leading to knowledge discovery and visualization is the main attraction of the book. Another important feature of the book is that one can find appropriate as well as illustrated examples exclusively with fisheries data. The statistics section includes biometrical and qualitative techniques in genetics and selective breeding of fish, besides fundamental statistical test, design of experiments and sampling methods for planning of experiments and survey in fisheries and aquaculture research. The book also includes econometric approach for technical efficiency estimation and input-output analysis, project evaluation, and impact assessment, linear programming, market intelligence, fisheries legislation, policy and IPR issues all of which are new in the field of fisheries and aquaculture.

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Book SynopsisThe book Plant Breeding and Genetics provides an overview of the fundamental principles of plant breeding and genetics, and is designed to serve as a textbook for undergraduate students. The books chapters cover a wide range of topics, including statistical and biotechnological applications, making it a useful resource for students studying undergraduate genetics and/or plant breeding. Each chapter begins with a clear definition of key terms and concepts, followed by an in-depth exploration of the chapters core issues. The book includes a variety of illustrations and solved numerical problems to aid in understanding, and concludes with a comprehensive glossary that includes modern developments. This book will be particularly useful for undergraduate students, but can also be beneficial for postgraduate students seeking a deeper understanding of the fundamentals of plant breeding and genetics.

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Book SynopsisThis book is intended to provide a comprehensive understanding of the fundamental concepts and practical applications of Cytology and Genetics. It encompasses all aspects of the subject, including information on the microscope, cell division, Mendelian principles of heredity, linkage and detection, gene mapping through recombination, multiple alleles, and gene interaction and probability. The practical information outlined in this guide will be of great benefit to students and educators in the fields of Biological and Agricultural Sciences.

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Book SynopsisAbiotic stresses have become a significant aspect of crop production, with their presence either in the soil, water, or atmosphere. The book aims to present the information regarding injury and tolerant mechanisms, variability for tolerance, breeding, and biotechnology for the improvement of crop plants against abiotic stresses in an organized manner, with up-to-date citations and a comprehensive literature of recent advances. The book emphasizes the elaboration of injury and tolerance mechanisms, as well as the development of improved genotypes against stress environments. The book also covers the plants symptoms of specific abiotic stress, reclamation of soil and crop/cropping patterns to overcome the effects of adverse conditions. Each topic is addressed with systematic approaches to develop abiotic stress-tolerant genotypes using biotechnological tools. The use of molecular markers in stress tolerance and the development of transgenic plants have also been detailed. Moreover, the book discusses the effects of air pollution and climate change on crop plants. It details the oxidative stress caused by abiotic stress, where plants produce a large quantity of free radicals (oxidants). The book is divided into seven major parts: physical stress (salt), water stresses (drought and waterlogging), temperature stresses (heat and cold), metal toxicities (aluminum, iron, cadmium, lead, nickel, chromium, copper, zinc, etc.), and non-metal toxicities (boron and arsenic), oxidative stress, and finally atmospheric stresses (air pollution, radiation, and climate change). This book will be beneficial for students and researchers, particularly Plant Breeders and Biotechnologists, as well as Botanists, to understand the injury and tolerance mechanisms and subsequently improve crop genotypes for abiotic stresses.

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Book SynopsisObjective Genetics book is meant for scholars and students who involved in preparation of ICAR-JRF, SRF, SAUs entrance examination of B.Sc. (Agri.) and M.Sc. Genetics and Plant Breeding.Table of Contentso Generic Term, o Cell, o Cell Division, o Cell Cycle, o Life Cycle of Plants, o Chromosome Morphology, o History of Development of Mendelian Gene Concept, o Pre-Mendelian Hybridization, o Mendelian Inheritance, o Lethal Genes, o Intergenic Gene Interaction, o Chi-Square Test, o Polygenic Inheritance, o Multiple Alleles, o Chromosome Theory of Inheritance, o Crossing Over, o Linkage, o Sex Determination, o Sex Linked, Sex Limited and Sex Influenced Genes, o Cytoplasmic Inheritance, o DNA - the Genetic Material, o Structure of DNA, o DNA Replication, o Protein Synthesis, o Genetic Code, o Gene Regulation, o Modern Concepts of Gene, o Chromosome and Chromatid Organisatio, o Special Chromosomes, o Variation in Chromosome Structure - Changes in the Number of Gene Loci, o Variation in Chromosome Structure-Changes Involving the Arrangement of Gene Loci, o Variation in Chromosome Number - Euploidy-Auto and Allopolyploids, o Variation in Chromosome Number-Aneuploids, o Missing Link

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Book SynopsisThis book provides an up-to-date review of classic and advanced bioinformatics approaches and their utility in rice research. It summarizes databases and tools for analyzing DNA, proteins and gene expression profiles, mapping genetic variations, annotation of protein and RNA molecules, phylogenetic analysis, and pathway enrichment.In addition, it presents high-throughput technologies that are widely used to provide deep insights into the genetic architecture of important traits in the rice genome. The book subsequently discusses techniques for identifying RNA-protein, DNA-protein interactions, and molecular markers, including SNP and microsatellites, in the contexts of rice breeding and genetics.Lastly, it explores various tools that are used to identify and characterize non-coding RNA in rice and their potential role in rice research.Table of ContentsChapter 1_Introduction to Bioinformatics.- Chapter 2_Statistics for bioinformatics.- Chapter 3_ Introduction of the databases of rice.- Chapter 4_Brief insight into the evolutionary history and domestication of wild rice relatives.- Chapter 5_3000 Genome project- A brief insight.- Chapter 6_ Databases and bioinformatics tools for data mining .- Chapter 7_Sequence Alignment.- Chapter 8_Gene identification and structure Annotation.- Chapter 9_Phylogenetic Analysis.- Chapter 10_RNA Structure Prediction. -Chapter 11_Structural Proteomics.- Chapter 12_Gene ontology and pathway enrichment analysis.- Chapter 13_High throughput sequencing technologies.- Chapter 14_Mapping algorithms in high-throughput sequencing.- Chapter 15_DNA–Protein Interaction Analysis (ChIP-Seq).- Chapter 16_RNA–Protein Interaction Analysis.- Chapter 17_SNP Identification and Discovery.- Chapter 18_Microsatellite Markers from whole genome and Transcriptomic Sequences. - Chapter 19_Genome-wide association study.- Chapter 20_Expression Profiling and Discovery of microRNA.- Chapter 21_Computational approaches in identifying long non-coding RNA.- Chapter 22_circRNA in rice.- Chapter 23_ Metagenomics.- Chapter 24_RNA-Induced Gene Silencing.- Chapter 25_Single-cell RNA sequencing technologies.- Chapter 26_Recent Advancement in NGS Technologies.

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Book SynopsisThis book summarizes the advanced computational methods for mapping high-density linkages and quantitative trait loci in the rice genome. It also discusses the tools for analyzing metabolomics, identifying complex polyploidy genomes, and decoding the extrachromosomal genome in rice.Further, the book highlights the application of CRISPR-Cas technology and methods for understanding the evolutionary development and the de novo evolution of genes in rice.Lastly, it discusses the role of artificial intelligence and machine learning in rice research and computational tools to analyze plant-pathogen co-evolution in rice crops.Table of ContentsChapter-1 Possibility of Uncoding Structural Organization of Genome in Rice: Prospects and Approaches By 3D Genome Sequencing.- Chapter-2 Bioinformatics Approaches for High Density Linkage Mapping in Rice Research.- Chapter-3 Quantitative Trait Locus Mapping in Rice.- Chapter-4 Metabolomics in Rice Improvement.- Chapter-5 Computational Approaches Towards Decoding the Extra Chromosomal Genome of Rice.- Chapter-6 Computational Epigenetics in Rice Research.- Chapter-7 Computational Approaches Towards Understanding Stress in Rice.- Chapter-8 Identifying Complex Polyploidy Genomes Using Bioinformatics Approaches.- Chapter-9 Perspectives and Challenges of Phenotyping in Rice.- Chapter-10 The CRISPR Technology and Application in Rice.- Chapter-11 De Novo Evolution of Genes in Rice.- Chapter-12 Artificial intelligence and machine learning in rice research.- Chapter-13 Intellectual Property and Rice Research.- Chapter-14 Plant Pathogen Co-Evolution in Rice .- Chapter-15 Conservation of Rice Germplasm by Bioinformatics Strategy.- Chapter-16 Recent Advances in Multi-Omics and Breeding Approaches Towards Drought Tolerance in Crops.

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Book SynopsisThis book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.Table of ContentsChapter 1_ introductory cancer biology. –Chapter 2_Cancer: Getting informed about the Basics. –Chapter 3_Tumour Biology: An Introduction. –Chapter 4_Role of Angiogenesis in Tumour–Chapter 5_Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis. –Chapter 6_MRI, CT, and PETSCAN: An Engineer’s Perspective. –Chapter 7_Diffusion, MRI, and Cancer Diagnosis: Physicists’ Outlook. –Chapter 8_Oncology: Radiation Oncologist’s View. –Chapter 9_Radiomics: Comprehensive and Advance Image Analysis based Radiological Investigations. –Chapter 10_Oncology: Biochemists’ Perspective. –Chapter 11_Oncology: Pathologist’s View. –Chapter 12_Surgical Oncology: An Overview. –Chapter 13_Medical Oncology in Cancer Treatment. - Chapter 14_Effects of Cancer Chemotherapy on Immune System. –Chapter 15_Side-effects of Cancer Chemotherapy. –Chapter 16_Telomerase and its Therapeutic Implication in Cancer. –Chapter 17_Pain Management in Oncology. –Chapter 18_Other Approaches in Cancer Research: Stem-cell Research, Translational Research, and Immuno-therapy. –Chapter 19_Cancer Cell Lines: It’s Implication in Therapeutics. –Chapter 20_ Genomics of Cancer. –Chapter 21_Diabetes and Cancer Link. –Chapter 22_Cancer Genomics and Diagnostics: Northeast Indian Scenario. –Chapter 23_Oncology Informatics, AI and Drug Discovery. –Chapter 24_Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies. –Chapter 25_Epidemiology of Cancer: Asian Perspective.

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Book SynopsisThis book provides insight into the use of molecular and genomic techniques to the study of populations of critically important species at various geographical scales. It delves into a wide range of issues relevant to biodiversity conservation, such as population differentiation, landscape genomics, ecological interactions, phylogenetics, phylogeography, metagenomics, molecular methods, and data processing. The current rate of biodiversity loss is unprecedented and valuable genetic resources are being lost at an alarmingly rate. Effective strategies to conserve these genetic resources are essential to maintain healthy ecosystems with inter-dependent species. The book is an invaluable resource for training undergraduate and graduate students, postdoctoral fellows, and for young researchers. This book is particularly useful for the policy makers and academics who want to learn about important concepts in population and conservation genetics and genomics.Table of ContentsChapter 1.Phylogenetics and its application in biodiversity conservation.- Chapter 2.Phylogenetics in the Context of Tree Diversity and Conservation .- Chapter 3.Conservation metagenomics: Understanding microbiomes for biodiversity sustenance and conservation .- Chapter 4.Overview of omics-assisted techniques for biodiversity conservation .- Chapter 5. Genetic consequences of fragmentation in tropical forests: Novel approaches to assess and monitor critically endangered species .- Chapter 6.Molecular markers in assessing genetic clonal fidelity for in vitro propagated endangered medicinal plants .- Chapter 7.Strategies, opportunities and challenges in crop genetic diversity conservation: a plant breeder’s perspective .- Chapter 8.Soil Microbial Metagenomics in Agroforestry System: Tools and Techniques .- Chapter 9.Phylogenetic and population genetic studies of Citrus genetic resources in northeast India: a review .- Chapter 10.Next-Generation Amplicon Sequencing: a cost-effective method for exploring microbial biodiversity .- Chapter 11.Molecular characterization and phylogeny of Clerodendrum species occurring in North Eastern Region of India by Internal Transcribed Spacer 2 of Nuclear DNA .- Chapter 12.Population genetic diversity of Dysoxylum binectariferum, an economically important tree species of the Western Ghats, India .- Chapter 13.Gut metagenomics of Pati hanh (Anas platyrhynchosdomesticus) .- Chapter 14.Morphological and molecular characterization of genome types in wild and cultivated bananas (Musa species) of two states in North Eastern India .- Chapter 15.Pollen digital image mapping and its symmetrical correlation using MATLAB.- Chapter 16.Role of Next-generation sequencing (NGS) in understanding the Microbial Diversity.

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Book SynopsisThis book collates the basic and advanced concepts of plant biotechnology and genomics along with the future trends. It discusses the combination of conventional breeding techniques with genomic tools and approaches leading to a new genomics-based plant breeding technology supporting crop plants that respond better to biotic and abiotic stress, and pathogen attacks. Plant genomics play an important role in developing more efficient plant cultivars which are essential for the neo green revolution needed to feed the world’s rapidly growing population. Plant genomic data is being utilized in genetic engineering to ensure that better and resilient varieties of crops are available ensuring food security. This book is of immense interest to teachers, researchers, crop scientists, capacity builders, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, biotechnology, genomics, soil science, and environmental sciences. National and International agricultural scientists and policy makers will also find this to be a useful read.Table of ContentsChapter 1. Introduction, Scope and Applications of Biotechnology and Genomics for Sustainable Agricultural Production.- Chapter 2. Structure and Organization of Plant Nuclear Genome.- Chapter 3. Transgenesis in Plants: Principle and Methods.- Chapter 4. Genetically Modified Crops and their Applications.- Chapter 5. Transcriptomics in Plant.- Chapter 6. Molecular Breeding and Marker Assisted Selection for Crop Improvement.- Chapter 7.Bioinformatics in Plant Genomics for Next Generation Plant Breeding.- Chapter 8. Whole Genome Sequencing of Plants: Past, Present and Future.- Chapter 9. Model Plants in Genomics.- Chapter 10. RNA Interference Technology in Plants: Mechanisms and Applications in Crop Improvement.- Chapter 11. Use of Genomics to Improve Stress Tolerance.- Chapter 12. Genetics of Plant Organelles: Plastid and Mitochondrial Genomes.- Chapter 13. DNA Barcoding in Plants: Past, Present and Future.- Chapter 14. Advances in Epigenetics for Crop Improvement and Sustainable Agriculture.- Chapter 15. Ethical Aspects and Public Perception on Plant Genomics.

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Book SynopsisThis book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.This work will attract readers’ interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author’s studies and to perform similar and extended studies themselves.Table of ContentsGeneral Introduction.- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression.- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent.- Enhanced Nuclear Accumulation of Pyrrole–Imidazole Polyamides by Incorporation of the Tri-arginine Vector.

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Book SynopsisThis book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics, as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferencesTable of Contents

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Book SynopsisThis book presents the discoveries made during nearly three decades of research on the parental shield bug, Parastrachia japonensis inhabiting Kyushu Island, Japan. P. japonensis has evolved a unique and fascinating life history, characterized by extreme behavioral and physiological adaptations that have culminated in a singularly dependent relationship with its lone host tree, Schoepfia jasminodora (Olacaceae), which is a generally scarce and unreliable resource. It is expected that the evolution of parental care behaviors in the strictly semelparous P. japonensis was more directly influenced by the benefit to females that arises from enhanced survivorship of current offspring, rather than any possible cost the females might incur in terms of reduced future reproductive success, because no future reproduction is possible. The authors explain how the different parental cares in this species enhance offspring survivorship in the context of the ecological conditions it has experienced over evolutionary time. The book begins with a recap of the earliest studies, the reports through 1991, and then introduces the many fascinating aspects of the life history, neurobiology, physiology and behavior of P. japonensis that have been newly discovered since, and those aspects that have been confirmed through experimentation over the past thirty years. This comprehensive review of information will be useful for comparative studies of parental care in other semelparous and iteroparous organisms experiencing both similar and different ecological constraints. The book will be of academic interest to undergraduate and graduate students of entomology, zoology, behavior, and behavioral ecology.Table of Contents

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Book SynopsisThe book deals with latest research achievements of Brassica scientists using omics approaches in understanding host-pathogen interaction, molecular detection, identification, and functional characterization of effectors/genes including pathogenomics and biometabolomics. Genomics of host-pathogen interaction is a source of information for the teachers, students, researchers, and policy makers to foster success in enhancing the Brassica production and productivity through the development of improved disease-resistant varieties with the use of omics technologies. It is a base and sound plate form for managing biological stresses of Brassica at global level. The book covers up-to-date information on genomics of host-pathogen interaction, pathogenomics of crucifers’ pathogen, and biometabolomics of host pathosystem supplemented with ample photographs, illustrations, and figures which make it stimulating, effective, and easy to comprehend for readers, researchers, biology students, teachers, and policy makers.Table of Contents1. Genomics of crucifers’ host-pathosystem - Prologue.- 2. Crucifers’ pathogens genome.- 3. Genomics of host- pathogen interaction.- 4. Molecular detection and Identification of pathogens, pathotypes and genes.- 5. Pathogenomics of pathogenic variability.- 6. Bio-metabolomics of crucifer’s host-pathosystem.- 7. Genomics of crucifer’s host-pathosystem at a glance.- 8. Protocols to study host-pathosystem.- 9. Future research priorities of crucifers’ host pathosystem.- 10. Subject index.

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Book SynopsisThis book provides a comprehensive reference for various plant bioactive compounds for research and pharmacological significance across the entire spectrum of phytochemical genomics. The book opens with general information on diversity, analysis and genomic basis of phytochemicals, computational approaches, databases for responsible genes, and biosynthetic pathways, and it delves very much into the details behind phytochemical diversity and diverse roles of plant metabolites. The later parts of the book also explore the direct drug discovery and omics approaches including metabolomics, transcriptomics, as well as gene editing technology experiments to further inspire readers into its unlimited potentials. Each chapter includes detailed analysis and relevant experiments for better and deeper understanding of the concepts. The book will be an invaluable aid for medicinal plant researchers and a rich source of information and advice for advanced undergraduates and graduates in the fields of medicine, nutraceuticals, cosmetics, flavor, and fragrance studies.Table of Contents1.Phytochemical genomics: integration of omics approaches for understanding genomic basis of phytochemicals.- 2.Gene-metabolite networks.- 3.Computational approaches in phytochemical genomics.- 4.Databases relevant to phytochemicals and genes responsible.- 5.Biosynthetic pathways of important metabolites using genomics and metabolomics approaches.- 6.Phytochemical diversity and the diverse roles of phytochemicals in plants.- 7.Role of genomics and metabolomics for breeding crops with higher quantity of metabolites.- 8.Metabolic quantitative trait loci mapping of medicinal plants and crops.- 9.Tools for metabolomics analysis of plants.- 10.Trichomes as an important chemical factories of metabolites.- 11.Stress and metabolites.- 12.Evolution of metabolite diversity and defense mechanisms in plants.- 13.Pathway engineering of genes.- 14.Demand-supply of phytochemicals and the need for ensuring sustainable supply of plants.- 15.Drug discovery and omics.- 16.Gene editing technologies for scaling up production of secondary metabolites.- 17.Medicinal plants and use of omics approaches.- 18.Metabolomics of important medicinal plants.- 19.Transcriptomics of important medicinal plants.

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Book SynopsisThis edited book provides a comprehensive and a reliable source of information on all major areas of diatom research. It addresses research advances in the key areas of diatom biology, morphology, systematics, phylogeny and ecology along with their interdisciplinary applications. Diatoms are the world’s most diverse group of algae populating the freshwater and marine ecosystems of the world. They are unicellular, photosynthetic, eukaryotes having ornate silicified cell walls. Diatoms contribute around 25% of annual global carbon fixation, which is more than all of the terrestrial rainforests combined. Diatoms underpin major aquatic food webs and drive global biogeochemical cycles and have several ecological and interdisciplinary applications. This book targets a wide range of audience including researchers, academicians, teachers and students of varied disciplines such as biology, environmental sciences, ecology, evolution, nanotechnology and other related disciplines. It is useful read for beginners as well as advanced researchers.Table of Contents1. Photosynthetic Pigments in Diatoms.- 2. Impact assessment: Diatom flora of free flowing and fragmented stretches of serially impounded Bhagirathi River (Indian Himalayan Region).- 3. Use of Multivariate Techniques for Quick Assessment of Hydropower Impacts on the Producer Community in Himalayan Rivers With a note on required sample size.- 4. Alpine lake environments and Psychrophile Diatoms around the World with a particular emphasis on Turkish glacial lakes.- 5. Ocean Acidification Conditions and Marine Diatoms.- 6. Diatom Algae for Carbon Sequestration in Oceans.- 7.Diatoms: A Potential for Assessing River Health.- 8. Terrestrial Diatoms and their Potential for Ecological Monitoring.- 9. Role of Diatoms in Forensics: A Molecular approach.- 10. Diatoms in Forensics: Adding new dimension to the growing relevance of diatoms in improving lives.- 11. Diatom silica a potential tool as biosensors and for biomedical field.- 12. Diatoms in biomedicines and nanomedicines.- 13. Recent Advances in Biomedicine: Diatomaceous Applications.- 14. Perspectives on the ecosystem services and need for conservation of diatomite and diatomaceous earth landscapes for India.- 15. Biofuels from Diatoms: Potential and Challenges.- 16. Potential Industrial Application of Diatoms for a Greener Future.- 17. The mechanism of ecosystem restoration and resilience of present-day coastal lagoons by coastal diatoms and their implications for management of successional diatomite landscapes.

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Book SynopsisThis book elucidates the sustainable production of commercially important biomolecules in medicines, food, and beverage processing, through biological systems, including microorganisms, animal cells, plant cells, tissues, enzymes, and in vitro. It discusses promising technologies for the manipulation of cells including, genetic engineering, synthetic biology, genome editing, and metabolic engineering. The initial chapters of the book introduce topics on biomanufacturing, circular economy, strain design and improvement, upstream and downstream processing. The subsequent chapters cover artificial intelligence-assisted production, designer cell factories, biosensors for monitoring biomolecules, different cells factories, biosynthetic pathways, and genome editing approaches for scale-up biomanufacturing. Lastly, the book discusses the opportunities and challenges of implementing biological systems for the production of biomolecules. ​This book is a valuable source for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand biomanufacturing for the sustainable production of biomolecules.Table of ContentsChapter 1. Strain design and optimization methods for sustainable production.- Chapter 2. Designer and minimal cells for production of biomolecules.- Chapter 3. Recent advances in downstream processing deployed in the treatment of pharmaceutical effluents.- Chapter 4. Microbial conversion of waste to biomolecules.- Chapter 5. Biosensor for detecting biomolecules.- Chapter 6. Artificial Intelligence Assisted Production of Biomolecules.- Chapter 7. Escherichia coli cell factory for synthesis of biomolecules.- Chapter 8. Bacillus subtilis cell factory.- Chapter 9. Pseudomonas putida cell factory.- Chapter 10. Cyanobacteria for marine based biomolecules.- Chapter 11. Yeast cell factory for biomolecules.- Chapter 12. Plant cell factory for biomolecules.- Chapter 13. Genetic manipulation of crop for enhanced food quality and nutrition towards sustainable production.- Chapter 14. Insect cell factory for production of biomolecules.- Chapter 15. Mammalian cell factor for biomolecules.- Chapter 16. Genome editing guided production of biomolecules.- Chapter 17. Cell free protein synthesis system for sustainable production of biofuels.- Chapter 18. Challenges and opportunities in biomanufacturing.

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Book SynopsisThis book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer. ​Table of ContentsChapter 1 An introduction to breast cancer.- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators.- Chapter 4 Cell cycle and cancer.- Chapter 5 cell cycle dysregulation in breast cancer.- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation.- Chapter 7 Breast tumor micro environment and CDks.- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis.- Chapter 9 CDK1 Dysregulation in Breast Cancer.- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers.- Chapter 11 Therapeutic implications of CDKs in Breast Cancer.- Chapter 12 Novel CDK Inhibitors in Breast Cancer.- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach.- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer.- Chapter 15 CDk inhibitor for treatment of breast cancer.- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer.- Chapter 17 Different cyclins and their significance in Breast cancer.

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Book SynopsisThis book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​Table of ContentsChapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity.- Chapter 2. Computation tools for prediction and analysis of genomic islands.- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study.- Chapter 4. Microbial genomic island discovery, visualization and analysis.- Chapter 5. Genomic islands in bacterial genome evolution and speciation.- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field.- Chapter 7. Genomic islands in nutritional fitness and adaptation.- Chapter 8. Genomic islands involved in iron uptake.- Chapter 9. Genomic islands in uropathogeneic E. coli.- Chapter 10. Genomic islands in Helicobacter species.- Chapter 11. Genomic islands in Staphylococcus.- Chapter 12. Genomic islands in Pseudomonas species.- Chapter 13. Genomic islands in Klebsiella pneumonia.- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae.- Chapter 15. Genomic islands in marine bacteria.- Chapter 16. Challenges in Eventing Horizontal Gene Transfer.- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands. ​

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Book Synopsis1. Groundnut (Arachis hypogaea): The Protein-Rich Oilseed of Adaptability and Nutrition.- 2. ALSI :  Omega 3 rich source for health and vitality.- 3. Grain Amaranth (Amaranthus spp.): The Sacred Seed of Ancient Civilizations.- 4. Buckwheat (Fagopyrum esculentum): The Resilient Crop with Nutritional Riches.- 5. Water Chestnut (Trapa natans L.): The Aquatic Treasure of Traditional Diets.- 6. Makhana (Euryale ferox): The Super Snack from Water.- 7. Barnyard Millet (Echinochloa spp.): The Fast-Growing Nutritious Staple.-  8.Proso Millet (Panicum miliaceum): The Prodigious Millet for Diverse Uses.- 9. Kalingda (Citrullus colocynthis): The Desert Melon with Medicinal Power.- 10. Shakarkandi (Sweet Potato) (Ipomoea batatas L.) The Nutrient-Rich Root of Resilience.- 11. Sago (Tapioca) Manihot esculenta: The starchy sustainer of energy.- 12.  Tikhur (East Indian Arrowroot) (Curcuma angustifolia Roxb.): The Starchy Root of Versatile Nutrition.- 13. Aonla (Indian Gooseberry) (Emblica officinalis Gaertn.): The Vitamin C Powerhouse for Immunity.- 14. Mahua (Madhuca indica): The Multifunctional Tree of Tradition and Sustenance.- 15. Poppy Seeds (Khus Khus) (Papaver somniferum): The Tiny Seed of Flavor and Nutrient Density.- 16. Saffron (Crocus sativus L.): Gold of the Spices.- 17. Tulsi (Holy Basil) (Ocimum tenuiflorum): The Sacred Herb of Wellness.- 18. Chia Seeds (Salvia hispanica): The Tiny Powerhouse of Omega-3 and Fiber.- 19. Halim Seeds (Garden Cress): The Ancient seed of Iron and Immunity.

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