Genetics (non-medical) Books

Book SynopsisHistory of Clinical Cytogenetics.- DNA, Chromosomes, and Cell Division.- Human Chromosome Nomenclature: An Overview and Definition of Terms.- Basic Cytogenetics Laboratory Procedures.- The Essentials of Light Microscopy.- Quality Control & Quality Assurance.- Instrumentation in the Cytogenetics Laboratory.- Autosomal Aneuploidy.- Structural Chromosome Rearrangements.- Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development.- The Cytogenetics of Infertility.- Prenatal Cytogenetics.- The Cytogenetics of Spontaneous Abortion.- Chromosome Instability.- The Cytogenetics of Hematologic Neoplasms.- The Cytogenetics of Solid Tumors.- Fluorescence in situ Hybridization (FISH).- Microarray-Based Cytogenetics.- Fragile X: A Family of Disorders: Changing Phenotype and Molecular Genetics.- Genomic Imprinting and Uniparental Disomy.- Genetic Counseling.Trade ReviewFrom the reviews of the third edition:“The audience includes those performing clinical cytogenetic testing or using results for genetic counseling or clinical care. It also would be of interest to anyone interested in cytogenetic analysis and application, from healthcare providers … to the educated lay public. … This is truly a remarkable and comprehensive book on clinical cytogenetics. … You would also want this book as a handy reference for which genetic abnormality is associated with what disease, and the best test method to use to identify the suspected abnormality.” (Valerie Ng, Doody’s Book Reviews, July, 2013)Table of ContentsSECTION 1 - Basic Concepts and Background1. History of Clinical CytogeneticsSteven L. Gersen2. DNA, Chromosomes, and Cell Division Martha B. Keagle3. Human Chromosome Nomenclature: An Overview and Definition of TermsMarilyn L. Slovak, Aaron Theisen, and Lisa G. ShafferSECTION II - Examining and Analyzing Chromosomes4. Basic Cytogenetics Laboratory ProceduresMartha B. Keagle and Steven L. Gersen5. The Essentials of Light MicroscopyNathan Claxton and Stephen Ross6. Quality Control & Quality AssuranceMartha B. Keagle7. Instrumentation in the Cytogenetics LaboratorySteven L. GersenSECTION III – Clinical Cytogenetics8. Autosomal AneuploidyJin-Chen C. Wang9. Structural Chromosome RearrangementsKathleen Kaiser-Rogers and Kathleen Rao10. Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex DevelopmentCynthia M. Powell11. The Cytogenetics of InfertilityLinda Marie Randolph12. Prenatal CytogeneticsLinda Marie Randolph13. The Cytogenetics of Spontaneous AbortionSolveig M. V. Pflueger14. Chromosome InstabilityXiao-Xiang ZhangSECTION IV – Cancer Cytogenetics15. The Cytogenetics of Hematologic NeoplasmsAurelia Meloni-Ehrig16. The Cytogenetics of Solid Tumors Linda D. Cooley and Kathleen S. WilsonSECTION V - Adjunct Technologies17. Fluorescence in situ Hybridization (FISH)Daynna J. Wolff18. Microarray-Based CytogeneticsLisa G. ShafferSECTION VI – Beyond Chromosomes19. Fragile X: A Family of Disorders: Changing Phenotype and Molecular GeneticsElaine B. Spector 20. Genomic Imprinting and Uniparental DisomyJin-Chen C. Wang21. Genetic CounselingSarah Hutchings Clark

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThe potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides. Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing in mammalian cells, transcription factor decoys, and modified oligonucleotide hybridization and genetic insertion. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsIntroduction: Y S Cho-Chung, Alan M. Gewirtz, and Cy A. Stein. Part I: Kill the Messenger: Gene Silencing by Nucleic Acid Molecules. 1. Knock-down of the Cytoprotective Gene, Clusterin, to Enhance Hormone and Chemosensitivity in Prostate and Other Cancers: Martin Gleave and Kim N. Chi. 2. Recognition of Chromosomal DNA in Human Cells by Peptide Nucleic Acids and Small Duplex RNAs: David R. Corey. Part II: Antisense and siRNA: Chemistry, Sequence Specificity, and Target Validation. 3. Design and Development of Thermolytic DNA Oligonucleotide Prodrugs: Andrzej Grajkowski, Joao Pedras-Vasconcelos, Cristina Ausín, Daniela Verthelyi, and Serge L. Beaucage. 4. Rationally Targeted, Conformationally Constrained, Oxetane-Modified Oligonucleotides Demonstrate Efficient Gene-Silencing Activity in a Cellular System: J B Opalinska and A M Gewirtz. Part III: Delivery Cellular and Phenotype Effect of Silencing Agents:. 5. In Vivo Potentialities Andrei Maksimenko, Valerie Polard, Marie Villemeur, Hind Elhamess, Patrick Couvreur, Jean-Remi Bertrand, Malam Aboubakar, Marina Gottikh, and Claude Malvy of EWS-Fli-1 Targeted Antisense Oligonucleotides-Nanospheres Complexes:. 6. Endo-Porter: A Novel Reagent for Safe, Effective Delivery of Substances into Cells: James E. Summerton. 7. Tumor Reversion: Protein Kinase A Isozyme Switching: Yoon S. Cho-Chung and Maria V. Nesterova. Part IV: Immune Modulation of and Resistance to Silencing Agents. 8. Therapeutic Potential of Oligonucleotides Expressing Immunosuppressive TTAGGG Motifs: Dennis M. Klinman, Ihsan Gursel, Sven Klaschik, Li Dong, Debbie Currie, and Hidekazu Shirota. 9. Breaking Tolerance to Tumors with Dendritic Cell-Based Immunotherapy: Ines Mende and Edgar G. Engleman. 10. Development of Resistance to RNAi in Mammalian Cells: Zhi-Ming Zheng, Shuang Tang, and Mingfang Tao. Part V: Transcription Silencing by Nucleic Acid Molecules. 11. The Development of Bioactive Triple Helix-Forming Oligonucleotides: Michael M. Seidman, Nitin Puri, Alokes Majumdar, Bernard Cuenoud, Paul S. Miller, and Rowshon Alam. 12. Transcription Factor Decoys: A New Model for Disease Intervention: Michael J. Mann. 13. DNA Damage Produced by 125I-Triplex-Forming Oligonucleotides as a Measure of Their Succesful Delivery into Cell Nuclei: Irina V. Panyutin, Olga A. Sedelnikova, William M. Bonner, Igor G. Panyutin, and Ronald D. Neumann. 14. Targeted Genome Modification via Triple Helix Formation: Jennifer M. Kalish and Peter M. Glazer. Part VI: Functional Genomics—Antisense/RNAi. 15. "Promoter Array" Studies Identify Cohorts of Genes Directly Regulated by Methylation, Copy Number Change, or Transcription Factor Binding in Human Cancer Cells: Yipeng Wang, Jun Hayakawa, Fred Long, Qiuju Yu, Ann H. Cho, Gaelle Rondeau, John Welsh, Shalu Mittal, Ian De Belle, Eileen Adamson, Michael Mcclelland, and Dan Mercola. 16. Application of Expression Genomics for Predicting Treatment Response in Cancer: Khew-Voon Chin, Leah Alabanza, Kazuyuki Fujii, Kazuya Kudoh, Tsunekazu Kita, Yoshihiro Kikuchi, Zachariah E. Selvanayagam, Yick Fu Wong, Yong Lin, and Wei Chung Shih. 17. Stability Regulation of mRNA and the Control of Gene Expression: Chris Cheadle, Jinshui Fan, Yoon S. Cho-Chung, Thomas Werner, Jill Ray, Lana Do, Myriam Gorospe, and Kevin G. Becker. Part VII: Chemosensitivity Enhancement by Antisense and RNAi. 18. Novel MDM2 p53-Independent Functions Identified through RNA Silencing Technologies: Zhuo Zhang, Hui Wang, Mao Li, Elizabeth Rayburn, Sudhir Agrawal, and Ruiwen Zhang. 19. Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640: Eric C. Lacasse, Ekambar R. Kandimalla, Peter Winocour, Tim Sullivan, Sudhir Agrawal, John W. Gillard, and Jon Durkin. Part VIII: Nucleic Acid Therapeutics for Human Diseases. 20. Induction of Apoptosis by G3139 in Melanoma Cells: Luba Benimetskaya, Johnathan C. Lai, Anastasia Khvorova, Sijian Wu, Paul Miller, and C A Stein. 21. Zebularine: A Unique Molecule for an Epigenetically Based Strategy in Cancer Chemotherapy: Victor E. Marquez, James A. Kelley, Riad Agbaria, Tisipi Ben-Kasus, Jonathan C. Cheng, Christine B. Yoo, and Peter A. Jones. 22. Chemoprevention with Protein Kinase A RI Antisense in DMBA-Mammary Carcinogenesis: Maria V. Nesterova and Yoon S. Cho-Chung

Read more less

Book SynopsisThe structure of DNA varies along its sequence, which can lead to sequence-dependent variations in the fidelity of DNA copying and repair. And because the probability of distinct classes of mutations varies along a DNA sequence, variation that affects fitness will have evolutionary implications, as selection acts on heritable variation. This Annals volume brings together a broad interdisciplinary group of researchers to explore the impact of increasing understanding of DNA structure, repair, replication, and organization on interrelated subjects ranging from evolution, to dependence of the effect of mutagens on environmental and sequence context, to noncanonical forms of information representation in genomes. NOTE: Annals volumes are avaialble for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Joun.aspx for more information about becoming a member.Table of ContentsOverview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution 1. Lynn Helena Caporale Genome hyperevolution and the success of a parasite 11. J. David Barry, James P. J. Hall, and Lindsey Plenderleith The tricky path to recombining X and Y chromosomes in meiosis 18. Liisa Kauppi, Maria Jasin, and Scott Keeney Sites of genetic instability in mitosis and cancer 24. Anne M. Casper, Danielle M. Rosen, and Kaveri D. Rajula The genome: an isochore ensemble and it’s evolution 31. Giorgio Bernardi Multiple levels of meaning in DNA sequences, and one more 35. Edward N. Trifonov, Zeev Volkovich, and Zakharia M. Frenkel Evolution of simple sequence repeat-mediated phase variation in bacterial genomes 39. Christopher D. Bayliss and Michael E. Palmer Indirect selection of implicit mutation protocols 45. David G. King G4 motifs in human genes 53. Nancy Maizels Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes 61. Baldomero M. Olivera, Maren Watkins, Pradip Bandyopadhyay, Julita S. Imperial, Edgar P. Heimer de la Cotera, Manual B. Aguilar, Estuardo Lopez Vera, Gisela P. Concepcion, and Arturo Lluisma Integrons and gene cassettes: hotspots of diversity in bacterial genomes 71. Ruth M. Hall Creative deaminases, self-inflicted damage, and genome evolution 79. Silvestro G. Conticello Three-dimensional architecture of the IgH locus facilitates class switch recombination 86. Amy L. Kenter, Scott Feldman, Robert Wuerffel, Ikbel Achour, Lili Wang, and Satyendra Kumar Preaching about the converted: how meiotic gene conversion influences genomic diversity 95. Francesca Cole, Scott Keeney, and Maria Jasin Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli 103. J.M. Moore, Hallie Wimberly, P.C. Thorton, Susan M. Rosenberg, and P.J. Hastings Implications of genetic heterogeneity in cancer 110. Michael W. Schmitt, Marc J. Prindle, and Lawrence A. Loeb Corrigendum for Ann. N.Y. Acad. Sci. 2009. 1182: 47-57 117.

Read more less

Book SynopsisWith the world population growth, food demand grows. Aquatic foods provide high quality protein, essential for human health. It is clearly visible that the production of aquatic organisms using aquaculture will have to increase, to the extent that the fishery productivity holds steady over the past few years, even increasing fishing effort. The total production of aquatic organisms by-catch (including fish, molluscs, crustaceans, etc.) represents 83.5 million tonnes in the year 2014, with a stable production for some years. On the other hand, aquaculture has grown enough in recent years. In the year 2006 the total output of aquatic organisms through cultivation was approximately 45 million tonnes in 2014 the production over 73 million tones. Since the establishment and technical domain about reproduction and hatchery of marine fish, has begun a process of genetic improvement, as the best individuals were selected for mating and reproduction in search of the best possible offspring. According to Dunham et al. (2000), breeding programs began in the 1960s. Molecular-based knowledge emerged in the 1980s and has continued to gain momentum. Efforts are now well established in traditional selective breeding, biotechnology and molecular genetics of finfish, and are rapidly developing for aquatic invertebrate domestication.Genetic improvement is the theory that aims to find the animals that produce the best offspring generation after generation, increasing the population average to some trait. The main objectives of the breeding programs are: increase animal health and increase productivity and product quality. However, on aquaculture, breeding programs are not common, and in many species the production is based only on the capture of wild animals. This can be explained, primarily because of the complexity of the reproductive cycle; the rapid increase of inbreeding in breeding stocks; and the few knowledge of the theory of genetic improvement for researchers, educators, etc. In addition to all this, the breeding programs of aquatic organisms face severe problems compared to terrestrial animals. The genetic improvement for aquatic organisms really is a challenging path ahead of us, for that we shall seek to carry out research to help this area to develop, benefiting the entire aquaculture chain.

Read more less

Book Synopsis* Provides specific examples of germplasm research related to climate change threats * Edited by internationally renowned experts in the field * The final chapter of the book draws a synthesis of the many issues raised within the bookTable of Contentsa: Preface 1: Food Security, Climate Change and Genetic Resources 2: Genetic Resources and Conservation Challenges under the Threat of Climate Change 3: Climate Projections 4: Effects of Climate Change on Potential Food Production and Risk of Hunger 5: Regional Impacts of Climate Change on Agriculture and the Role of Adaptation 6: International Mechanisms for Conservation and Use of Genetic Resources 7: Crop Wild Relatives and Climate Change 8: Climate Change and On-farm Conservation of Crop Landraces in Centres of Diversity 9: Germplasm Databases and Informatics 10: Exploring ‘Omics’ of Genetic Resources to Mitigate the Effects of Climate Change 11: Harnessing Meiotic Recombination for Improved Crop Varieties 12: High Temperature Stress 13: Drought 14: Salinity 15: Response to Flooding: Submergence Tolerance in Rice 16: Effects of Climate Change on Plant–Insect Interactions and Prospects for Resistance Breeding Using Genetic Resources"

Read more less

Book SynopsisMaintaining food security in the face of human population increase and climate change is one of the critical challenges facing us in the 21st Century. Utilisation of the full range of agrobiodiversity will be a necessary tool in addressing this challenge. In this book a team of international contributors review all aspects of utilization and conservation of crop wild relative (CWR) and landrace (LR) diversity as a basis for crop improvement and future food security. Enhancing Crop Genepool Use covers four key areas: · Characterization techniques - novel 'omics' techniques and predictive tools that can be used to identify adaptive traits and expedite plant breeding. · Conservation strategies - how to develop national, regional and global CWR and LR conservation strategies, how better to target conservation to meet the needs of the plant breeding community, and how to integrate CWR and LR diversity into existing biodiversity conservation programmes. · Facilitating CWR and LR use - pre-breeding using 'exotic' germplasm, meeting breeders' needs, integrating the conservation and user communities, and policy enhancement. · Informatics development - improving characterization, trait and conservation data management and accessibility, and inter-information system operability. This book will appeal to a wide array of specialists and postgraduate students, such as those working in the fields of agrobiodiversity conservation and use, conservation, ecology, botany, genetics, plant breeding and agriculture.Table of ContentsPart I: Breeder's use of exotic germplasm 1: Using phenomics and genomics to unlock landrace and wild relative diversity for crop improvement 2: Pre-domesticating wild relatives as new sources of novel genetic diversity 3: Unravelling quinoa domestication with wild ancestors 4: Screening wild Vigna species and cowpea (Vigna unguiculata) landraces for sources of resistance to Striga gesnerioides 5: Wild Lactuca saligna a rich source of variation for lettuce breeding 6: Capturing wild relative and landrace diversity for crop improvement using a new selection tool to exploit genetic resources in durum wheat Part II: Improving access to PGRFA 7: How the Focused Identification of Germplasm Strategy (FIGS) is used to mine plant genetic resources collections for adaptive traits 8: Predictive characterization methods for accessing and using CWR diversity 9: Keeping a finger on the pulse: monitoring the use of CWR in crop improvement Part III: CWR conservation 10: Joining up the dots: a systematic perspective of crop wild relative conservation and use 11: Europe’s crop wild relative diversity: from conservation planning to conservation action 12: An approach for in situ gap analysis and conservation planning on a global scale 13: The distributions and ex situ conservation of crop wild relatives: a global approach 14: National strategies for the conservation of crop wild relatives 15: Crop wild relatives, a priority in Jordan? - developing a national strategy for the conservation of plant diversity in Jordan using a participatory approach 16: Establishing systematic crop wild relative conservation within the United Kingdom 17: Optimized site selection for the in situ conservation of forage CWRs: a combination of community and genetic level perspectives 18: Developing a crop wild relative conservation strategy for Finland 19: Developing national crop wild relative in situ conservation strategy for Lithuania: creation of national CWR inventory and its prioritization 20: Priorities for conservation of crop wild relatives at Indian National Genebank 21: Strategies for detecting climate adaptations in the wild pearl millet for future breeding use 22: Assessment of the conservation status of Mesoamerican crop species and their wild relatives in light of climate change Part IV: LR conservation 23: Landrace conservation of maize in Mexico and evolutionary breeding 24: Use of spontaneous sexually-produced new landraces of a vegetatively propagated crop of the Andes (Oxalis tuberosa Mol.) to enhance in situ conservation 25: A long-term systematic monitoring framework for on-farm conserved potato landrace diversity 26: A European in situ (on-farm) conservation and management strategy for landraces 27: Using landraces in agriculture, food and cooking: experiences around a big city in Southern Europe 28: Hungarian strategies for the conservation of crop wild relative and landrace diversity 29: Assessment of Italian landrace density and species richness: useful criteria for developing in situ conservation strategies 30: Chickpea wild relatives and landraces of Georgia 31: Landrace inventories and recommendations for in situ conservation in Finland Part V: Community-based conservation and use 32: Community biodiversity management (CBM): A participatory methodology that integrates empowerment, livelihoods and on-farm management of agrobiodiversity 33: Evolutionary Plant Breeding: A method for rapidly increasing on-farm biodiversity to support sustainable livelihoods in an era of climate change 34: Value chain development: a silver bullet for agrobiodiversity conservation and use? Part VI: PGR conservation and use policy 35: Moving slowly towards the light: a review of efforts to create a global system for PGRFA over the last half century 36: On the conservation and sustainable use of plant genetic resources in Europe: a stakeholder analysis 37: Towards an improved European Plant Germplasm System 38: Impact of the genetic resources policy landscape on food security: an assessment of the Genetic Resources and Intellectual Property Rights Programme 39: What do we have to lose? Monitoring crop genetic diversity Part VII: Conservation informatics 40: Improved utilization of crop diversity for rationalized breeding using data interoperability 41: Implementation of a PGR Global Documentation System in Portugal 42: The GRIN-Taxonomy Crop Wild Relative Inventory

Read more less

Book SynopsisAdvances in research and development reveal the immense diversity and potential of marine genetic resources. Under international law, no specific regime applies to these complex and paradoxical objects of use. The Law of the Sea Convention sets a framework that is partly inadequate for this new category of resources. The Biodiversity Convention and the Nagoya Protocol only address the genetic resources of national areas. Patents allow their holder to exercise a monopoly on exploiting biotechnological creations to extensive claims, questioning the common nature of biodiversity and related knowledge. They hinder research and the objectives of biodiversity law. The legal and practical rules of physical and functional access vary in geometry. They focus on the valorization of research results, crystallizing conflicts of interest between suppliers and users. Sustainable research and development is essential to the knowledge and protection of marine biodiversity. The qualification of marine genetic resources in common, standard contractual tools, distributed research and development infrastructures, negotiation of an agreement on sustainable use and conservation of biodiversity beyond the limits of national jurisdiction, would To remove these inconsistencies.Table of ContentsForeword ix Introduction xi Chapter 1. The Scientific Representation of the Living World: A Dual Concept Between Nature’s and Humans’ Shares 1 1.1. Natural sciences: the given living world 2 1.1.1. Taxonomy: the observation of the living world 2 1.1.2. Systematics: the identification of the living world 10 1.2. Life sciences: the constructed living world 18 1.2.1. Biological sciences: the exploration of the living world 18 1.2.2. Bio-technosciences: the instrumentalization of the living world 25 Part 1. Singular Objects Moving Toward Reservation 35 Chapter 2. Exploitable Raw Materials 37 2.1. Genetic material: natural resources defined according to their conditions of appropriation 38 2.1.1. Appropriable natural things 41 2.1.2. Things on the verge of exclusive appropriation 45 2.2. Marine genetic resources: biological resources defined according to their destination 58 2.2.1. Traditional marine living resources exploited for food and industrial purposes 59 2.2.2. New marine biological resources searched for the purposes of scientific and biotechnological valorization 63 Chapter 3. Patentable Biotechnological Inventions 75 3.1. The patentability of life of any origin: an established principle 80 3.1.1. The uncontested patentability of inventions of microorganic origin 81 3.1.2. The logical acceptance of the patentability of inventions of macroorganic origin 87 3.2. The patentability of life in all its forms: a questionable reality 98 3.2.1. An overall commodification of the living world 99 3.2.2. A gradual privatization of research in life sciences 109 Part 2. Global Objects Moving Toward Sharing 117 Chapter 4. Residual Res Communes 119 4.1. Res communes due to disinterest 120 4.1.1. Non-appropriable things as a matter of principle 121 4.1.2. Things of common use 134 4.2. Common resources at risk 137 4.2.1. The tragedy of the genetic pool 138 4.2.2. The tragedy of the scientific “anticommons” 151 Chapter 5. Reconstructing the Commons 157 5.1. Renewal of the commons in a context of global interdependencies 160 5.1.1. Global public goods: a theoretical and global approach to the commons 162 5.1.2. Common-pool resources: a concrete and nuanced approach to the commons 166 5.2. An attempt to apply renewed figures of the commons to marine biodiversity and associated knowledge 172 5.2.1. A desirable communitarization 172 5.2.2. A communitarization difficult to implement 186 Conclusion 197 Appendices 199 Appendix 1. Classical Marine Bioprospecting: Biochemistry and Genetic Engineering 201 Appendix 2. Modern Marine Bioprospecting: Metagenomics 203 Appendix 3. The Drug Research and Development Steps 205 Appendix 4. Risk Assessment in the Bioprospecting Process 207 Appendix 5. Aleatory Component Comparison in Fishing and Bioprospecting 209 Appendix 6. Patent Claims Over Genes of Marine Origin 211 Appendix 7. Illustrative Database on Marine Biotechnological Innovations 213 Bibliography 231 Index 263

Read more less

Book SynopsisThis book constitutes a fascinating and in-depth analysis of the significance of the requirement of industrial application within gene patenting and how this influences innovation in Europe and the US. The author addresses an area normally overlooked in biotechnology patenting due to the predominance of the ethical debate and, in doing so, produces a unique approach to dealing with concerns in this field. Patenting Genes: The Requirement of Industrial Application is the result of extensive research into the legal history of the industrial application requirement as well as exploration of the broad range of decisions on DNA patentability. This requirement has taken a prominent role within DNA patenting decisions in Europe since the 1998 Biotech Directive, which Dr Diaz Pozo argues has worked efficiently to control claims to human gene sequences and encouraged progress in genetic research. A broad selection of decisions on the patentability of DNA in both European Union and US courts is discussed, emphasizing the mirroring of the European approach in US cases. Academics and students of patent law and biotechnology innovation, as well as policy formulators, will find this book of great interest and value. Activists and practitioners interested in the patentability of human gene inventions in Europe and the US will also benefit from this original work.Trade Review'This insightful and accessible book provides a uniquely thorough examination of the European requirement of industrial application and the determination of the scope of protection of gene patents. It is a scholarly work of the highest quality and rewards readers with its clear and accessible approach to the often overlooked legal issues surrounding the patentability of biotechnological inventions on grounds of industrial application. The book is highly recommended for academics and for practitioners alike.' --(Duncan Matthews, Queen Mary University of London, UK)'This book provides a valuable contribution to the understanding of industrial application in patent law. It shows how - with the evolvement of biotechnology patent law - a formerly obscure patentability requirement became a key tool for patent law policy. A detailed discussion of the Biotechnology Directive, as well as in-depth analysis of EPO and CJEU jurisprudence, makes this book worthwhile reading for any IP lawyer concerned with patent law.' --(Herbert Zech, University of Basel, Switzerland)Table of ContentsContents: 1. Introduction 2. Genetic inventions and patent law in Europe 3. The European requirement of industrial application 4. The industrial applicability of human genetic inventions 5. The requirement of industrial application and the interpretation of the exclusion of human genetic discoveries from patent protection 6. The requirement of industrial application and the determination of the scope of protection of gene patents 7. Human gene patents, patent clusters and innovative progress 8. Conclusion Index

Read more less

Book SynopsisSince the first edition of this book was published in 2002, the field of quantitative genetics, genomics and breeding has changed markedly. In response, only four chapters have been updated for this new edition, and the remaining 16 chapters are entirely new. This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base. This book contains: chapters by expert authors from six continents; state-of-the-art information on topical areas relative to crop improvement; coverage of genome-editing techniques.Table of Contents1: Vignettes of the History of Genetics Section I: Quantitative Genetics: Plant Breeding, Bioinformatics, Genome Editing and G × E Interaction 2: Food and Health: The Role of Plant Breeding 3: The Importance of Plant Pan-genomes in Breeding 4: Genome Editing Technologies for Crop Improvement 5: Epigenome Editing in Crop Improvement 6: Bioinformatics and Plant Breeding 7: Bioinformatics Approaches for Pathway Reconstruction in Orphan Crops — A New Paradigm 8: Advances in QTL Mapping and Cloning 9: Genotype–Environment Interaction and Stability Analyses: An Update 10: Biplot Analysis of Multi-environment Trial Data 11: Design and Analysis of Multi-year Field Trials for Annual Crops 12: Advances in the Definition of Adaptation Strategies and Yield-stability Targets in Plant Breeding Section II: Intersection of Breeding, Genetics and Genomics: Crop Examples 13: Prediction with Big Data in the Genomic and High-throughput Phenotyping Era: A Case Study with Wheat Data 14: Quantitative Genetics in Improving Root and Tuber Crops 15: Genomic Selection in Rice: Empirical Results and Implications for Breeding 16: Novel Breeding Approaches for Developing Climate-resilient Rice 17: Quantitative Genetics, Molecular Techniques and Agronomic Performance of Provitamin-A Maize in Sub-Saharan Africa 18: Developments in Genomics Relative to Abiotic Stress-tolerance Breeding in Maize During the Past Decade 19: Exploiting Alien Genetic Variation for Germplasm Enhancement in Brassica Oilseeds 20: Biofortified Pearl Millet Cultivars Offer Potential Solution to Tackle Malnutrition in India

Read more less

Book SynopsisBridging the gap between genome and phenotype, the transcriptome is a molecular-level snapshot of the act of living. Transcriptomics shows which genes are expressed into proteins in a specific tissue of a specific organism at a specific time and condition. This book gives an account of the extraordinary diversity of ways transcriptomics has been and can be utilised in basic and applied entomological research. It encompasses a vast range of disciplines within entomology, applying transcriptomics to the study of over one million described species of insects. It covers a vast range of disciplines from phylogenomics to pest management, from ecology to physiology, and from behavior to evolutionary biology. The book covers the breadth and depth of transcriptomics use in research to showcase the utility of this technology in all disciplines. Research examples in the book are relevant to fish, birds, plants, and fungi, as well as insects and other arthropods, helping scientists in any field, using any system, to understand what transcriptomics can do for them. The book: Introduces transcriptomics theory and practice for researchers of all levels wishing to gain an insight into how to apply these techniques to their own fields. Showcases the myriad ways transcriptomics can be used to answer biological questions. Is written by a team of international experts describing their own experiences, giving guidance for applying it to the reader's own work. Reviews how transcriptomics research has helped entomologists push their fields further and make new discoveries.Table of Contents1: Harnessing Transcriptomics to Study Insect Biology – Kyle M Lewald, Joanna C. Chiu 2: From Reads to Genes – Chengran Zhou, Guanliang Meng, Shanlin Liu 3: Transcriptomics in Pest Management Research - Antonino Malacrinò 4: Aphid Transcriptomics—Past, Present and Future – Sampurna Sattar, Gary A Thompson 5: Transcriptomic Research on Honey Bee-Associated Pathogens – James P. Tauber 6: Cytochrome P450s in the Era of Transcriptomics - Bernarda Calla, May R Berenbaum 7: Whole-body Transcriptome of the Douglas-fir Seed Chalcid, Megastigmus spermotrophus, Reveals Ecological and Evolutionary Insights. - Amber R Paulson, Jürgen Ehlting, Patrick von Aderkas, Steven J. Perlman. 8: Differential Transcriptome Profiling for Identification of Cellulose Degrading Enzymes in Ctenolepisma longicaudata - Ratnasri Pothula, Brian R. Johnson, William E. Klingeman, Matthew Huff, Margaret E. Staton, Juan Luis Jurat-Fuentes 9: Using RNA-Seq to Help Identify Functions in Unknown Organs - Matan Shelomi 10: A practical guide for functional transcriptomics: A case study in RNA interference and qPCR to understand the explosive chemistry of Brachinus bombardier beetles (Coleoptera: Carabidae). - Aman Gill, Melanie Gee, Kipling Will

Read more less

Book SynopsisThe genetic improvement of fish for aquaculture and related fisheries has seen huge advances over recent years. Building upon the previous two editions of Aquaculture and Fisheries Biotechnology: Genetic Approaches, this 3rd edition offers a presentation of traditional selective breeding, modern genetic biotechnology, genomics, gene transfer and gene editing, and the latest developments in genetic biotechnology such as epigenetics, xenogenesis and genome-wide association study coupled with commercial application, the impact of government regulation and expectations for the future. It provides a firm grounding in relevant aspects of classical genetics, before focusing on particular aspects such as sex reversal and breeding as applied in aquaculture and fisheries. It also explores how more recent molecular genetics, genomics and biotechnology techniques can be used and combined in improvement programmes for fish and aquaculture species. A glossary explains the latest terminology used in biotechnology and genetics.This book will be useful for research scientists and students in marine biotechnology, aquaculture biotechnology, and fish genetics and breeding.

Read more less

Book SynopsisGenome sequencing has become a basic tool of plant and animal breeding. Reduced costs have allowed the sequencing of thousands of plant lines or cultivars, leading to previously unobtainable insights into genetic impacts during breeding and generating large numbers of novel candidate breeding genes. This book summarizes the impacts that the genome sequencing revolution has had on agriculture with reference to applications across species and locations. It explains new techniques and their use in understanding epigenetics, breeding and conservation. It is a useful resource for scientists wanting to learn how different fields of agriculture have adapted novel genome sequencing technologies to their requirements, and for those wanting to transfer technologies and lessons learned from one field of agriculture to another.This book is a useful resource for students and researchers in biotechnology, genetics, genomics and breeding.

Read more less

Book SynopsisRNA interference (RNAi) has the potential to make major contributions towards sustainable crop production and protection with minimal environmental impacts compared to other technologies. RNAi is being developed and exploited both within plants (i.e. host-induced gene silencing, HIGS) and/or as topical applications (e.g. spray-induced gene silencing, SIGS) for targeting pest and pathogen genes and for manipulating endogenous gene expression in plants. Chapters by international experts review current knowledge on RNAi, methods for developing RNAi systems in GM plants and applications for crop improvement, crop production and crop protection. Chapters examine both endogenous systems in GM plants and exogenous systems where interfering RNAs are applied to target plants, pests and pathogens. The biosafety of these different systems is examined and methods for risk assessment for food, feed and environmental safety are discussed. Finally, aspects of the regulation of technologies exploiting RNAi and the socio-economic impacts of RNAi technologies are discussed.Table of ContentsChapter 1: Introduction to RNAi in Plant Production and Protection. Bruno Mezzetti, Jeremy Sweet and Lorenzo Burgos Chapter 2: Gene silencing to induce pathogen-derived resistance in plants. Zhen Liao, Elena Zuriaga, Ángela Polo and Maria L. Badenes Chapter 3: Exogenous application of small RNAs as a tool for gene function discovering. Barbara Molesini and Tiziana Pandolfini Chapter 4: The “Trojan Horse” approach for successful RNA interference in inscects. Dimitrios Kontogiannatos, Anna Kolliopoulou and Luc Swevers. Chapter 5: Biogenesis and functional RNAi in fruit-trees. Michel Ravelonandro and Pascal Briard Chapter 6: Gene silencing or gene editing: the pros and cons. Huw D Jones Chapter 7: Application of RNAi technology in Forest Trees. Matthias Fladung, Hely Haggman and S. Sutela Chapter 8: Host-induced gene silencing and spray-induced gene silencing for crop protection against viruses. Angela Ricci, Silvia Sabbadini, Laura Miozzi, Bruno Mezzetti and Emanuela Noris. Chapter 9: Small talk and large impact: the importance of small RNA molecules in the fight of plant diseases. Kristian Persson Hodén and Christina Dixelius Chapter 10: dsRNA stability during external applications – an overview. Ivelin Pantchev, Goritsa Rakleova and Atanas Atanassov Chapter 11: Boosting dsRNA delivery in plant and insect cells with peptide- and polymer-based carriers: cases-based current status and future perspectives. Kristof de Schutter, Olivier Christiaens, Clauvis Nji Tizi Taning and Guy Smagghe Chapter 12: Environmental safety assessment of RNAi plants for pest control. Salvatore Arpaia, Olivier Christiaens, Paul Henning Krogh, Kimberly Parker and Jeremy Sweet Chapter 13: Food and feed safety assessment of RNAi plants and products. Hanspeter Naegeli, Gijs Kleter and Antje Dietz-Pfeilstetter Chapter 14: Regulatory aspects of RNAi in plant production. Werner Schenkel and Achim Gathmann Chapter 15: The Economics of RNAi technology in plant breeding: from the innovation landscape to consumer acceptance. Dario Frisio and Vera Ventura Chapter 16: Communication challenges of RNAi and selected communication messages from iPLANTA for dissemination. Hilde-Gunn Opsahl-Sorteberg

Read more less

Book SynopsisDocuments and critically analyses the photographs that helped strengthen as well as bring down the Eugenics Movement. Using a large body of racial-type images and a variety of historical and archival sources, and concentrating mainly on developments in Britain, the USA and Nazi Germany, the author argues that photography, as the most powerful visual medium of the late nineteenth and early twentieth centuries, was vital to the Eugenics Movement's success -- not only did it allow eugenicists to identify the people with superior and inferior hereditary traits, but it helped publicise and lend scientific authority to eugenicists' racial theories. The author further argues for a strong connection between the racial-type photographs that eugenicists created and the photographic images produced by nineteenth-century anthropologists and prison authorities, and that the photographic works of contemporary liberal anthropologists played a significant role in the Eugenics Movement's downfall. Besides adding to our knowledge of photography's crucial role in helping to authorise and implement some of the most controversial social policies of modern times, this book makes a major contribution to our understanding of the history of racism. Most accounts of eugenics have been written by history of science scholars, with an emphasis on the history of science and medicine. In contrast, "Picture Imperfect" looks at eugenics from the standpoint of its most significant cultural data -- racial-type photography, investigating the techniques, media forms, and styles of photography used by eugenicists, and relating these to their racial theories and their social policies and goals. Indeed, the visual archive was crucially constitutive of eugenic racial science because it helped make many of its concepts appear both intuitive as well as scientifically legitimate. Discussion of the history of the eugenics movement encompasses a wide narrative, including Nazi history, US politics, criminology and prison studies, and propaganda.Trade Review"This book makes a significant contribution to an underexamined and important topic. Eugenics had an immense (mainly negative) impact on twentieth-century social and political history, and as Anne Maxwell demonstrates this was in large part because of its use of modern visual technologies, particularly photography. This story should not be allowed to disappear from cultural memory and Anne Maxwell's careful and path-breaking scholarship will do much to keep it there." -- Simon During, Johns Hopkins University.Table of ContentsIntroduction; Racial-type Photographs in the Colonial Period; The Degenerate Face: Nineteenth-Century Prison Photographs; The Eugenics Movement Begins: Galton and the Races of Britain; Building a Healthy Nation: Eugenic Images in the United States, 1890-1935; Creating the Master Race: Photography and Racial Selection in Germany; Sub-Human Versus the Master Race: Racial-Type Photographs and Nazi Party Propaganda; Eugenics Under Fire: the Racial-type Imagery of Boas, Du Bois, Huxley and Hadden; Conclusion; Index.

Read more less

Book SynopsisDocuments and critically analyses the photographs that helped strengthen as well as bring down the Eugenics Movement. Using a large body of racial-type images and a variety of historical and archival sources, and concentrating mainly on developments in Britain, the USA and Nazi Germany, the author argues that photography, as the most powerful visual medium of the late nineteenth and early twentieth centuries, was vital to the Eugenics Movement's success -- not only did it allow eugenicists to identify the people with superior and inferior hereditary traits, but it helped publicise and lend scientific authority to eugenicists' racial theories. The author further argues for a strong connection between the racial-type photographs that eugenicists created and the photographic images produced by nineteenth-century anthropologists and prison authorities, and that the photographic works of contemporary liberal anthropologists played a significant role in the Eugenics Movement's downfall. Besides adding to our knowledge of photography's crucial role in helping to authorise and implement some of the most controversial social policies of modern times, this book makes a major contribution to our understanding of the history of racism. Most accounts of eugenics have been written by history of science scholars, with an emphasis on the history of science and medicine. In contrast, "Picture Imperfect" looks at eugenics from the standpoint of its most significant cultural data -- racial-type photography, investigating the techniques, media forms, and styles of photography used by eugenicists, and relating these to their racial theories and their social policies and goals. Indeed, the visual archive was crucially constitutive of eugenic racial science because it helped make many of its concepts appear both intuitive as well as scientifically legitimate. Discussion of the history of the eugenics movement encompasses a wide narrative, including Nazi history, US politics, criminology and prison studies, and propaganda.Trade Review"This book makes a significant contribution to an underexamined and important topic. Eugenics had an immense (mainly negative) impact on twentieth-century social and political history, and as Anne Maxwell demonstrates this was in large part because of its use of modern visual technologies, particularly photography. This story should not be allowed to disappear from cultural memory and Anne Maxwell's careful and path-breaking scholarship will do much to keep it there." -- Simon During, Johns Hopkins University.Table of ContentsIntroduction; Racial-type Photographs in the Colonial Period; The Degenerate Face: Nineteenth-Century Prison Photographs; The Eugenics Movement Begins: Galton and the Races of Britain; Building a Healthy Nation: Eugenic Images in the United States, 1890-1935; Creating the Master Race: Photography and Racial Selection in Germany; Sub-Human Versus the Master Race: Racial-Type Photographs and Nazi Party Propaganda; Eugenics Under Fire: the Racial-type Imagery of Boas, Du Bois, Huxley and Hadden; Conclusion; Index.

Read more less

Book SynopsisRecent advances in plant genomics and molecular biology have revolutionized our understanding of plant genetics, providing new opportunities for more efficient and controllable plant breeding. Successful techniques require a solid understanding of the underlying molecular biology as well as experience in applied plant breeding. Bridging the gap between developments in biotechnology and its applications in plant improvement, Molecular Plant Breeding provides an integrative overview of issues from basic theories to their applications to crop improvement including molecular marker technology, gene mapping, genetic transformation, quantitative genetics, and breeding methodology.Table of Contents1: Introduction 2: Molecular Breeding Tools: Markers and Maps 3: Molecular Breeding Tools: Omics and Arrays 4: Populations in Genetics and Breeding 5: Plant Genetic Resources: Management, Evaluation and Enhancement 6: Molecular Dissection of Complex Traits: Theory 7: Molecular Dissection of Complex Traits: Practice 8: Marker-assisted Selection: Theory 9: Marker-assisted Selection: Practice 10: Genotype-by-environment Interaction 11: Isolation and Functional Analysis of Genes 12: Gene Transfer and Genetically Modified Plants 13: Intellectual Property Rights and Plant Variety Protection 14: Breeding Informatics 15: Decision Support Tools

Read more less

Book SynopsisQuantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This advanced-level textbook covers all the statistical methods that have been used or proposed for detection and analysis of QTL and marker- and gene- assisted selection in animal genetics and breeding, as well as new advances that have revolutionized the field since the first edition.Trade Review"...the book is certainly a must-have for anyone involved in the statistical analysis of QTL studies in livestock... and (is) a useful textbook for advanced undergraduate and postgraduate students" - Chris Haley, Roslin Institute, on the first edition."Table of Contents1: Principles of Parameter Estimation 2: Random and Fixed Effects, the Mixed Model 3: Historical Overview 4: Experimental Designs to Detect QTL, Generation of Linkage Disequilibrium 5: QTL Parameter Estimation for Crosses between Inbred Lines 6: Advanced Statistical Methods for QTL Detection and Parameter Estimation 7: Analysis of QTL as Random Effects 8: Statistical Power to Detect QTL, and Parameter Confidence Intervals 9: Optimization of Experimental Designs 10: Fine Mapping of QTL 11: Complete Genome QTL Scans: The Problem of Multiple Comparisons 12: Multiple Trait QTL Analysis 13: Principles of Selection Index and Traditional Breeding Programmes 14: Marker-assisted Selection:Theory 15: Marker-assisted Selection : Results of Simulation Studies 16: Marker-assisted Introgression

Read more less

Book SynopsisThe understanding of pig genetics and genomics has advanced significantly in recent years, creating fresh insights into biological processes. This comprehensive reference work discusses pig genetics and its integration with livestock management and production technology to improve performance. Fully updated throughout to reflect advances in the subject, this new edition also includes new information on genetic aspects of domestication, colour variation, genomics and pig breeds, with contributions from international experts active in the field.Table of Contents1: Systematics and Evolution of the Pig 2: Genetic Aspects of Pig Domestication 3: Molecular Genetics of Coat Colour Variation 4: Genetics of Morphological Traits and Inherited Disorders 5: Molecular Genetics 6: Immunogenetics 7: Cytogenetics and Chromosome Maps 8: Pig Genomics 9: Behaviour Genetics of the Domestic Pig 10: Biology and Genetics of Reproduction 11: Transgenics and Modern Reproductive Technologies 12: Developmental Genetics 13: Pig Genetic Resources 14: Genetics of Performance Traits 15: Genetics of Meat Quality and Carcass Traits 16: Genetic Improvement of the Pig 17: Pigs as a Model for Biomedical Sciences 18: Breeds of Pigs 19: Standard Genetic Nomenclature of the Pig, with Glossaries 20: Index

Read more less

Book SynopsisFood legumes are important constituents of human and animal nutrition, supplying high quality proteins crucial for a balanced diet. These crops also play an important role in low-input agricultural production systems by fixing atmospheric nitrogen. Despite systematic and continuous breeding efforts by legume researchers all over the world, substantial genetic gains have not been achieved. These issues require immediate attention, and overall, a paradigm shift is needed in breeding strategies to strengthen our traditional crop improvement programs. To this end, Biology and Breeding of Food Legumes provides extensive information on their history, origin, evolution and botany, as well as breeding objectives and procedures, nutritional improvement, industrial uses, post-harvest technology and recent developments made through biotechnological intervention.Table of Contents1: History, Origin and Evolution 2: Domestication 3: Biology of Food Legumes 4: Breeding for Improvement of Cool Season Food Legumes 5: Breeding for Improvement of Warm Season Food Legumes 6: Distant Hybridization and Alien Gene Introgression 7: Polyploidy 8: Cytology and Molecular Cytogenetics 9: Molecular Cytogenetics in Physical Mapping of Genomes and Alien Introgressions 10: Micropropagation 11: Androgenesis and Doubled-Haploid Production in Food Legumes 12: Genetic Transformation 13: Male Sterility and Hybrid Production Technology 14: Mutagenesis 15: Breeding for Biotic Stresses 16: Breeding for Abiotic Stresses 17: Legume Improvement in Acidic and Less Fertile Soils 18: Molecular Breeding Approach in Managing Abiotic Stresses 19: Trait Mapping and Molecular Breeding 20: Improving Protein Content and Nutrition Quality 21: Underutilized Food Legumes: Potential for Multipurpose Uses 22: Legumes as a Model Plant Family 23: Plant Genetic Resources and Conservation of Biodiversity 24: Seed Dormancy and Viability 25: Postharvest Technology 26: Value Addition and International Trade

Read more less

Book SynopsisNow available in paperback, Molecular Plant Breeding provides an integrative overview of issues from basic theories to their applications to crop improvement. Chapters include discussions of breeding methodology, quantitative genetics, genomics and bioinformatics and present statistical issues related to gene mapping, marker-assisted selection and genotype by environment interactions in clear and concise language. Providing an integrated profile of molecular breeding in plants, this book will be an essential resource for researchers and students involved in plant biology and breeding, genetics and applied genomics.Table of Contents1: Introduction 2: Molecular Breeding Tools: Markers and Maps 3: Molecular Breeding Tools: Omics and Arrays 4: Populations in Genetics and Breeding 5: Plant Genetic Resources: Management, Evaluation and Enhancement 6: Molecular Dissection of Complex Traits: Theory 7: Molecular Dissection of Complex Traits: Practice 8: Marker-assisted Selection: Theory 9: Marker-assisted Selection: Practice 10: Genotype-by-environment Interaction 11: Isolation and Functional Analysis of Genes 12: Gene Transfer and Genetically Modified Plants 13: Intellectual Property Rights and Plant Variety Protection 14: Breeding Informatics 15: Decision Support Tools

Read more less

Book SynopsisThis book comprises the first volume of a series which reports the outcomes of the European Union Concerted Action Programme on Genetic Hearing Impairment. The aim is to bring together clinical geneticists and audiologists, as well as basic scientists and other clinicians with a general interest in this field, to standardise the audiological and terminological approaches and publish state of the art interdisciplinary studies.Table of ContentsPreface. Contributors. Part I Gene therapy. Chapter 1 Gene therapy for hearing disorders - AK Lalwani, GJ Carvalho, JJ Han and AN Mhatre. Part II Radiology. Chapter 2 Radiology of inner ear defects - PD Phelps. Part III Computer Systems Chapter 3 An Internet database on genetic non-syndromal hearing impairments - M. Mazzoli, L. Saggin, SD Hatzopouilos and A Martini. Chapter 4 A decision support system for the diagnosis of syndromal genetic hearing impairment - S Crino, A D'Amico, S Grisanti and G Grisanti. Part IV Epidemiology Chapter 5 Epidemiology of hereditary hearing impairment in childhood - preliminary estimates from the European Union - A Parving, RJC Admiraal, F Apaydin, E Arslan, A Davis, O Dias, H Fortnum, G Grisanti, M Gross, M Hess, K Konradsson, G Lina-Granade, VE Newton, C O'Donovan, E Orzan, M Sorri, D Stephens, MD Tsakanikox, M Waagenaar and K Welzl-Müller. Chapter 6 The German Registry for Hearing Impairment in Children: preliminary results - A Cherechevskaia, A Costa, E Rosztok, M Hess and M Gross. Chapter 7 Recessive hearing impairment in two birth cohorts in western Sicily - G Grisanti, AM Amodeo, S Crino and E Martines. Chapter 8 Aetiology of hearing impairment in children borth in northern Finland ijn 1975-1979 and in 1985-1989 (Abstract) - E Maki-Torkko, P Lindholm, M Vayrynen and M Sorri. Part V Audiovestibular tests. Chapter 9 Audiometric criteria for linkage analysis in genetic hearing impairment - FL Wuyts, PH Van de Heyning an F Declau. Chapter 10 Audioscan notches in carriers of genetic hearing impairment - F Zhao, D Stephens, R Meredith and VE Newton. Chapter 11 Cochlear irregulatities in obligate carriers of recessive genetic hearing impairment and in control subjects - G Lina-Granade, M Kreiss, T Gelas, L Collet and A Morgon. Chapter 12 Three-dimensional video-oculography for the detection of genetic vestibular dysfunction at the level of the threee semicircular canals and the otoliths (Abstract) - FL Wuyts, PH Van de Heyning, H Kingma, L Bourmans and D Van Dyck. Part VI Non-syndromal autosomal recessive hearing impairment. Chapter 13 Homozygosity mapping applied to hereditary hearing impairment - localizing recessive deafness genes - RJH Smith, A Ramesh, CR Srikumari Srisailapathy, K Fukushima, S Wayne, A Chen, L Van Laer, J Ashley, RIZ Zbar, M Lovett and G Van Camp. Chapter 14 A Turkish kindred with autosomal recessive non-syndromal hearing impairment segregates DFNB9 (Abstract) - SM Leal, E Vitale, F Apaydin, Y Hu, C Barnwell, M Iber, T Kandogan, U Braendle, HP Zenner, M Schwalb and O Cura. Chapter 15 Assessment of the contribution of the loci DFNA1-10 and DFNB1-9 in inherited hearing impairment in two populations: The United Arab Emirates and the British Pakistani populations (Abstract) - KA Brown, G Karban, G Parry, LL Moynihan, AH Janjua, LI Al-Gazali, VE Newton, AF Markham and RF Mueller. Part VII Non-syndromal autosomal dominant hearing impairment. Chapter 16 Hereditary dominant non-syndromal progressive hearing impairment in a large family in southern Italy - A Bojano, L Califano and P Capparuccia. Chapter 17 Autosomal dominant non-syndromal progressive sensorineural hearing impairment: audiological evalution of a Dutch DFNA2 family (Abstract) - H Kunst, HAM Marres, PLM Huygen, P Coucke, P Willems and CWRJ Cremers. Chapter 18 Autosomal dominant congenital severe sensorineural hearing impairment - localization of a disease gene to chromosome 11q by linkage in an Austrian family (Abstract) - K Kirschhofer, JBN Kenyon, DM Hoover, P Franz, K Weopoltshammer, F Wachtler and WJ Kimberling. Part VIII X-Linked hearing impairment Chapter 19 Identification of a novel locus for non-syndromal X-linked sonsorineural impairment (DFN6) on Xp22 (Abstract) - I del Castillo, M Villamar, M Sarduy, L Romero, C Herraiz, F Javier Hernandez, M Rodriguez, I Borras, A Montero, J Bellon, M Cruz Tapia and F Moreno. Part IX Mitochondrial hearing impairment Chapter 20 Nuclear candidate genes for 'mitochondrial deafness' - HT Jacobs, ZH Shah, V Migliosi, SK Lehtinen, A Rovio and K O'Dell. Chapter 21 A mitochondrial point mutation at position 7472 causes early onset hearing impairment and late onset neurological symptoms. Report of a Dutch and a comparison with a Sicilian family - RJH Ensink, PLM Huygen, HAM Marres, K Verhoeven, G Van Camp and GW Padberg. Chapter 22 Genetic study of mitochondrially inherited sensorineural hearing impairment in eight large families from Spin and Cuba - M Sarduy, I del Castillo, M Villamar, L Romero, C Heraiz, F Javier Hernandex, M Cruz Tapia, C Magarino, D Menendez del Castillo, I Menendez-Alejo, R Ramirez, B Arellano, C Morales, J Bellon and F Moreno. Chapter 23 Hearing impairment in mitochondrial point mutation - E Orzan, L Bartolomei, V Magnavita and E Arslan. Chapter 24 Prevalence of the base pair 3243 mutation of the tRNALeu gene in the mitochondrial DNA in a population-based cohort of patients with sensorineural hearing impairment (Abstract) - S Uimonen, I Hassinen, M Sorri and K Majamaa. Part X Syndromal conditions Chapter 25 Otorhinolaryngological manifestations of Stickler syndrome linked to chromosome 6 near the COL11A2 gene - RJC Admiraal, HG Brunner, PLM Huygen and CWRJ Cremers. Chapter 26 Dominant hemifacial microsomia in a four-general pedigree - A McInerney, R Winter and M Bitner-Glindzicz. Chapter 27 Variability of expression of sensorineural hearing loss in Usher syndrome: report of a family - D Zanetti and AR Antonelli. Chapter 28 Mpv 17 - Glomerulosclerosis gene is essential for inner ear function - AM Meyer zum Gottesberge, B Eschen, A Reuter, L Kintrup and H Weiher. Chapter 29 Cloning of a cadidate gene for hearing defects in CATCH 22 syndrome (Abstract) - A Pizzuti, G Novelli, A Ratti, F Amati, A Mari, G Calabrese, S Nicolis, V Silani, B Marino, G Scarlato, S Ottolenghi, R Mingarelli and B Dallapiccola. References. Index.

Read more less

Book SynopsisCystic fibrosis (CF) is one of the most common genetic diseases, affecting about 70,000 people throughout the world, with over 1,000 new cases diagnosed each year. This book describes the symptoms of CF including lung disease, digestive problems, pancreatic insufficiency, liver disease, intestinal obstruction, and infertility. It explains how CF is caused by mutations in the CFTR gene encoding a protein ion channel that maintains the balance of salt and water in the lungs and other organs. The book presents CF as an autosomal recessive disease that can arise in families with no prior history of CF. The reader will learn about treatments and therapies for CF, including antibiotics for infections, medicines for improved digestion, respiratory therapy, and pancreatic enzyme replacement. The book describes promising new pharmaceutical discoveries that enable personalized medicine for the treatment of CF. It evaluates the prospects for curing CF through gene therapy and explains how genome editing may be used in the future to correct the CFTR gene mutations underlying CF.

Read more less

Book SynopsisThis book is an overview of autism spectrum disorder (ASD), an early childhood condition that affects 1 in 68 children in the United States, and an estimated 1 to 2 percent of children worldwide. ASD causes impaired social skills, communication problems, and repetitive behaviors. The severity of ASD symptoms varies widely, ranging from mild effects with minimal impacts on functionality to severe effects that interfere with functionality and can prevent independent living. ASD is a complex trait disease caused by mutation of multiple ASD susceptibility genes, but it also occurs as part of monogenic genetic syndromes. Genetic testing for ASD is described in the book, and examples of ASD susceptibility genes. No treatments are available for the core symptoms of ASD, but the book describes therapies and drug treatments that can modulate them and address some of the health complications of ASD. The book presents new ASD biomarkers that can be used for better diagnosis and explores the hopeful prospect of personalized medicine for ASD.

Read more less

Book SynopsisThis book presents Down syndrome, which is the most common chromosomal disorder in humans, occurring at a rate of about 1 in 700 births. It describes the characteristic physical features caused by Down syndrome and the myriad of symptoms and health complications it brings, including heart defects, congenital vision and hearing loss, abnormalities of the musculoskeletal system, digestive problems, epilepsy, leukemia, an increased risk of infectious disease, dementia, and intellectual disability. Readers will learn about methods by which Down syndrome can be diagnosed prenatally or at birth, and the cause of Down syndrome as extra copies of the approximately 250 genes on chromosome 21. The book describes treatments and therapies for Down syndrome, and approaches to the education of children with it. Future prospects for the diagnosis and treatment of Down syndrome are presented, including experimental drugs, stem cell therapies, a process by which embryos produced in a clinical laboratory can be screened for Down syndrome before being used to establish a pregnancy, and several Down syndrome gene therapy strategies.

Read more less

Book SynopsisHemophilia is a genetic disease that impairs the normal process of blood clotting and results in uncontrolled external and internal bleeding. The reader of this book will learn how a diagnosis of hemophilia is made by blood clotting tests and measurements of clotting factor levels in blood. The book describes how hemophilia A and B are caused by mutations in genes that encode clotting factor VIII and clotting factor IX, respectively, both of which are carried on the X chromosome. As a result, almost all children born with hemophilia A and B are boys. Hemophilia C is caused by mutations in the clotting factor XI gene on chromosome 4, and occurs in males and females with equal frequency. The author details the use of factor replacement therapy to treat hemophilia, and evaluates the prospects for curing hemophilia through gene therapy and genome editing.

Read more less

Book SynopsisThis book describes Huntington's disease (HD), a rare neurodegenerative genetic disorder that causes a triad of motor, cognitive, and psychiatric/behavioral symptoms and affects about 6 in 100,000 people worldwide. Although the age of onset of HD symptoms is usually 30 to 50 years, a rare juvenile-onset form of HD also occurs. The autosomal dominant pattern of inheritance followed by HD is illustrated in the book with pedigree scenarios. The author details how mutations in the HTT gene on chromosome 4 cause HD and how a genetic test can be used by people who might have inherited adult-onset HD and couples who are at risk for passing HD on to their children. The book describes the available treatments for HD and presents new approaches such as experimental drugs, stem cell therapy, and gene therapy that might be able to effectively treat or even cure HD.

Read more less

Book SynopsisThis book presents muscular dystrophy (MD) as a group of genetic diseases with a worldwide occurrence of about 1 in 3,500 births that causes muscle wasting and weakening. It describes Duchenne MD as the most common type of MD, almost exclusively affecting males at a rate of about 1 in 5,000 boys, and eight rarer types of MD that are categorized by age of onset, muscles affected, disease progression, severity of symptoms, and health complications. The author describes how physical examination, muscle biopsy, medical imaging, and genetic testing is used to diagnose MD He further explains the underlying causes of the various types of MD as mutations in genes that encode proteins needed for the development, function, maintenance, and replacement of muscle cells and illustrates patterns by which they are inherited.There is no treatment that can reverse the progressive deterioration of muscles caused by MD, but the book offers insight into drug treatments and physical therapies that help maintain muscle strength and reduce health complications. It concludes with explanations of promising new ways to treat or perhaps cure MD, including experimental drugs, stem cell therapy, and gene therapy.

Read more less

Book SynopsisThis book describes newborn screening as a public health program for the early detection of genetic disorders. It presents the recommended uniform screening panel (RUSP), a list of genetic disorders recommended by the U.S. government for states to include in newborn screening programs. The author describes the categorization of RUSP genetic disorders, discusses the symptoms and health complications of examples from each category, and explains clinical laboratory tests used for newborn screening. The book explores the underlying molecular genetic causes of genetic disorders, and how this information is used for genetic testing during newborn screening and diagnosis. It presents the patterns of inheritance of monogenic genetic disorders, and uses hypothetical family scenarios to illustrate them. Treatments and therapies for selected RUSP genetic disorders are described that illustrate the benefits of early diagnosis. The book describes future prospects for the prevention, diagnosis, and treatment of genetic disorders detected by newborn screening, including experimental drug treatments, the possibility of newborn genome sequencing, and gene therapy.

Read more less

Book SynopsisThis book describes how obesity results from an imbalance between the intake of food energy and the expenditure of energy from physical activity and increases the risk of serious health problems including heart disease, stroke, osteoarthritis, and several types of cancer. Obesity is a global health problem that has reached epidemic levels. The worldwide prevalence of adult obesity is 13 percent of adults and 7 percent of children. The author explains how body mass index (BMI) can be used to screen for obesity, but that its diagnosis depends on clinical measurement of total body fat content and distribution. The book describes rare forms of obesity caused by a single gene or a genetic syndrome, and common obesity, a complex disease caused by multiple genetic and environmental risk factors. The book presents examples of obesity susceptibility genes and describes obesity genetic testing. It details how obesity can usually be treated with dietary changes, increased physical activity, and behavioral modification, but that people with extreme obesity or those who have serious health complications, require pharmaceutical or surgical interventions. Dr. Eckdahl discusses promising prospects for the treatment of obesity involving new pharmaceuticals, stem cell therapy, gene therapy, and fecal microbiota transplants.

Read more less

Book SynopsisThis book presents examples of hereditary blindness and deafness that illustrate the large variety of genetic diseases that affect vision and hearing. It describes seven hereditary eye diseases, three genetic syndromes that cause deafness, and four types of nonsyndromic deafness. The author explains the diagnosis of hereditary blindness and deafness in children and adults and describes the patterns of inheritance of blindness and deafness, illustrating each with family scenarios. The practice of genetic testing is described, which can provide information that prospective parents can use to make reproductive decisions. The text also presents treatments and therapies for hereditary blindness and deafness such as hearing aids, cochlear implants, and corneal implants. It describes future prospects for diagnosing, treating, and curing hereditary blindness and deafness, including experimental drugs, stem cell therapy, preimplantation genetic diagnosis, and gene therapy.

Read more less

Book SynopsisSickle cell disease (SCD) is the most common genetic blood disorder in the world. Millions of people in the world have SCD and about 300,000 babies are born with it each year. Readers will learn about the major symptoms of SCD, including chronic anemia, delayed growth, spleen dysfunction, opportunistic infections, vision loss, leg ulcers, stroke, and heart problems. The book explains how the primary cause of SCD is a gene mutation that causes hemoglobin to polymerize in red blood cells, making them adopt an abnormal sickle shape. Sickled cells carry less oxygen and occlude blood vessels in tissues and organs throughout the body. The reader will learn how SCD is inherited and how genetic testing can provide information that prospective parents can use to make reproductive decisions. The book presents treatments for SCD such as pain medications, antibiotic therapy, blood transfusions, and bone marrow transplantation. Future prospects for diagnosing, treating, and curing SCD are evaluated, including maternal blood screening, preimplantation genetic diagnosis, gene therapy, and genome editing.

Read more less

Book SynopsisInfectious diseases caused by bacteria and viruses exist in many forms and significantly affect human health. The sources of infectious diseases are vast, but in most cases arise from infectious microorganism such as bacteria or viruses that are able to establish growth or replication in humans, harming specific systems of the human body. This book introduces the reader to the basic differences between bacteria and viruses, particularly focusing on structures that contribute to the infectious properties of the microorganism. Chapters describe the cause, mode of transmission, symptoms, and treatments of five important diseases, taking into consideration the molecular interactions between host cells and infectious agents. Specifically, examples of viral infection (Influenza caused by the Influenza virus and hemorrhagic fever caused by the Ebola virus) and specific examples of bacterial infections (salmonellosis caused by Salmonella, gastrointestinal disease caused by Shiga-like toxin E. coli, and tuberculosis caused by Mycobacterium tuberculosis) are discussed in each chapter. The book ends with some future work related to treatment of these critical infectious diseases, noting the importance of drug resistance of infectious agents in treatment regimens.

Read more less

Book SynopsisIn life-threatening forms of cancer, cells stop working correctly, grow, divide, and spread throughout the body in harmful ways. These diseases impact the lives of many people, directly for those diagnosed and indirectly for the friends and families of those diagnosed. So many distinct forms of cancer with multiple unique diagnostic tools and approaches to treatment can be overwhelming for those diagnosed and those supporting them. Historical struggles with cancer can create a hopeless perception of disease prognosis, but advances in cancer diagnosis and treatment mean that many cancers can be well managed and even cured. This book discusses four types of cancer: skin, lung, breast, and prostate cancer. Wrestling with a diagnosis of one of these cancers can be complicated by the variety of treatment choices available and the unique medical history associated with both the patient and the cancer. The complexity of diagnosis and treatment requires that each cancer be considered a distinct disease, with some underlying common features. The author describes these common features and then discusses each cancer in terms of symptoms, diagnosis, causes, treatments, and future advances.

Read more less

Book SynopsisVector borne diseases transmitted through ticks and mosquitos cause serious loss of life and significantly impact human populations worldwide. Each of these diseases is caused by a distinct pathogen, and symptoms vary depending on the type and severity of infection. The spread of these diseases occur through the blood meals of tick or mosquitos, where the pathogen gains access to the human body, usually triggering an immune response that contributes to disease progression. Understanding the interdependence of pathogen to disease vector along with transmission route to humans shapes our diagnosis and treatment of these diseases. This book focuses on five distinct examples of vector borne disease: Malaria, West Nile, Lyme disease, dengue fever, and bubonic plaque. Malaria involves the mosquito vector and occurs when mosquito transmit the Plasmodium parasite to humans. West Nile and dengue fever also involve different mosquito vectors, but in this case transmission of the West Nile virus or dengue fever virus cause disease. Fleas transmit the bubonic plague causing bacterium Y. pestis. Lyme disease results from the transmission of the bacteria Borrelia burgdorferi to humans through the bit of a tick. In each case we consider current and future issues related to disease progression, diagnosis, and treatments.

Read more less

Book SynopsisAcquired immunodeficiency syndrome, or AIDS, is a disease of the immune system that is caused by the human immunodeficiency virus (HIV). AIDS has caused significant loss of life with considerable social and economic consequences worldwide. HIV must infect a host cell in order to replicate, and once infected, the host cell is unable to function properly. Since HIV infects specific cells of the host immune system, HIV infection impairs the ability of the patient to fight infections and kill cancer cells, therefore most deaths associated with HIV infection occur due to cancer or opportunistic infections. There is no cure for HIV, but advancements in treatments mean that an HIV positive person could experience a normal lifespan with sustained daily care and medication designed to prevent HIV replication and spread. These medications primarily target viral proteins that allow HIV to infect host cells, replicate, and spread in the body. Work continues to find a way to eliminate HIV from patients and develop new pharmaceutical targets to address concerns of drug resistant strains of HIV. Worldwide awareness of how the virus infects, is treated, and spreads within populations is a critical component to control the current AIDS pandemic.

Read more less

Book SynopsisVaccinations provide an effective way to prevent fatal diseases or reduce their symptoms. This book highlights four infectious diseases: polio, tetanus, measles, and mumps. These four diseases are very harmful to human health and are difficult to treat after the infection because they are caused by a toxin or pathogenic virus. In all four cases, the disease exhibits different modes of transmission and progression of symptoms, which require unique treatment regimens. However, all cases can be prevented by vaccinations administered prior to infection.This book summarizes the symptoms and disease progression of all the four diseases and provides information about the toxin or virus that causes each disease. The ability to harness our immune system through vaccination is discussed in the context of disease prevention. Minor and infrequent risks associated with vaccination are also described, but the very dangerous misconception that vaccines cause autism or other major illnesses is strongly refuted.

Read more less

Book SynopsisThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.Table of Contents1 Genes and chromatin1.1 Central dogma of molecular biology1.2 Impact of chromatin structure1.3 Epigenetics enables gene expression1.4 Gene regulation in the context of nuclear architecture2 Basal transcriptional machinery2.1 Core promoter2.2 TATA box and other core promoter elements2.3 Genome-wide core promoter identification2.4 TFIID and Mediator as paradigms of multi-protein complexes3 Transcription factors and signal transduction3.1 Site-specific transcription factors and their domains3.2 Classification of transcription factors3.3. Activation of transcription factors3.4 Programing cellular differentiation by transcription factors3.5 Inflammatory signaling via NF-B3.6 Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors4.1 The nuclear receptor superfamily4.2 Molecular interactions of nuclear receptors4.3 Physiological role of nuclear receptors5 Genome-wide principles of gene regulation5.1 Next-generation sequencing5.2 Gene regulation in the context of Big Biology5.3 Exploring genome-wide transcription factor binding5.4 Integrating epigenome-wide datasets6 Chromatin modifiers6.1 Cytosines and their methylation6.2 Histone modifications6.3 Gene regulation via chromatin modifiers6.4 Sensing energy metabolism via chromatin modifiers7 Epigenetics7.1 Epigenetics and chromatin7.2 Genome-wide understanding of epigenetics7.3 CTCF and genetic imprinting7.4 Epigenetics in health and disease8 Chromatin remodeling and organization8.1 Nucleosome positioning at promoters8.2 Chromatin remodeling8.3 Transcriptional dynamics in the presence of chromatin8.4 Organization of the nucleus9 Regulatory impact of non-coding RNA9.1 Non-coding RNAs9.2 miRNAs and their regulatory potential9.3 Long ncRNAs9.4 Enhancer RNAs

Read more less

Book SynopsisMicrobiome research has focused on microorganisms that live within the human body and their effects on health. During the last few years, the quantification of microbiome composition in different environments has been facilitated by the advent of high throughput sequencing technologies. The statistical challenges include computational difficulties due to the high volume of data; normalization and quantification of metabolic abundances, relative taxa and bacterial genes; high-dimensionality; multivariate analysis; the inherently compositional nature of the data; and the proper utilization of complementary phylogenetic information. This has resulted in an explosion of statistical approaches aimed at tackling the unique opportunities and challenges presented by microbiome data. This book provides a comprehensive overview of the state of the art in statistical and informatics technologies for microbiome research. In addition to reviewing demonstrably successful cutting-edge methods, particular emphasis is placed on examples in R that rely on available statistical packages for microbiome data. With its wide-ranging approach, the book benefits not only trained statisticians in academia and industry involved in microbiome research, but also other scientists working in microbiomics and in related fields.Table of Contents1. Tree-guided regression and multivariate analysis of microbiome data - Hongu Zhao and Tao Wang.- 2. Computational methods for metagenomic assemblies and strain identification - Hongzhe Li.- 3. Graphical models for microbiome data - Ali Shojaie.- 4. Bayesian models for understanding the modulating factors of microbiome data - Francesco Denti, Matthew D. Koslovsky, Michele Guindani, Marina Vannucci, and Katrine L. Whiteson.- 5. Use of variable importance in microbiome studies - Hemant Ishwaran.- 6. Log-linear models for microbiome data - Glen Satten.- 7. Quantification of amplicon sequences in microbiome samples using statistical methods - Karin Dorman.- 8. TBD - Jeanine Houwing Duistermaat.- 9. Analyzing microbiome data by employing the power of abundance ratios - Zhigang Li.- 10. Beta diversity analysis - Michael Wu.- 11. MicroPro: using metagenomic unmapped reads to provide insights into human microbiota and disease associations - Fengzhu Sun.- 12. Statistical methods for feature selection in microbiome studies - Peng Liu.- 13. A Bayesian restoration of the duality between principal components of a distance matrix and operational taxonomic units in microbiome analyses - Somnath Datta and Subharup Guha.

Read more less

Book SynopsisThis book is the first comprehensive compilation of deliberations on whole genome sequencing of the diploid and tetraploid alfalfa genomes including sequence assembly, gene annotation, and comparative genomics with the model legume genome, functional genomics, and genomics of important agronomic characters. Other chapters describe the genetic diversity and germplasm collections of alfalfa, as well as development of genetic markers and genome-wide association and genomic selection for economical important traits, genome editing, genomics, and breeding targets to address current and future needs. Altogether, the book contains about 300 pages over 16 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers, and scientists in the academia and relevant private companies interested in genetics, breeding, pathology, physiology, molecular genetics and breeding, biotechnology, and structural and functional genomics. The work is also useful to seed and forage industries.Table of Contents

Read more less

Book SynopsisDemand for agricultural crops and nutritional requirement continues to escalate in response to increasing population. Also, climate change exerts adverse effects on agriculture crop productivity. Plant researchers have, therefore, focused to identify the scientific approaches that minimize the negative impacts of climate change on agricultural crops. Thus, it is the need of the hour to expedite the process for improving stress tolerance mechanisms in agricultural crops against various environmental factors, in order to fulfil the world’s food demand. Among the various applied approaches, the application of phytohormones has gained significant attention in inducing stress tolerance mechanisms.Jasmonates are phytohormones with ubiquitous distribution among plants and generally considered to modulate many physiological events in higher plants such as defence responses, flowering and senescence. Also, jasmonates mediate plant responses to many biotic and abiotic stresses by triggering a transcriptional reprogramming that allows cells to cope with pathogens and stresses. Likewise, salicylates are important signal molecules for modulating plant responses to environmental stresses. Salicylic acid influences a range of diverse processes in plants, including seed germination, stomatal closure, ion uptake and transport, membrane permeability and photosynthetic and growth rate.Understanding the significant roles of these phytohormones in plant biology and from agriculture point of view, the current subject has recently attracted the attention of scientists from across the globe. Therefore, we bring forth a comprehensive book “Jasmonates and Salicylates Signalling in Plants” highlighting the various prospects involved in the current scenario. The book comprises chapters from diverse areas dealing with biotechnology, molecular biology, proteomics, genomics, metabolomics, etc. We are hopeful that this comprehensive book furnishes the requisite of all those who are working or have interest in this topic.Table of ContentsChapter 01Jasmonates and Salicylates: Mechanisms, Transport and Signalling during Abiotic Stress in PlantsAkbar Hossain1,*, Zahoor Ahmad2, Debjyoti Moulik3, Sagar Maitra4, Preetha Bhadra5, Adeel Ahmad6, Sourav Garai7, Mousumi Mondal7, Anirban Roy8, Ayman El Sabagh9,10, Tariq Aftab11Chapter 02Salicylic acid and jasmonic acid in generating salt stress tolerant plantsAnkur Singh, Aryadeep Roychoudhury*Chapter 03Role of Jasmonic and Salicylic acid signaling in plants under UV-B stressKrishna Kumar Choudhary1, Suruchi Singh2, Madhoolika Agrawal3 and S. B. Agrawal3*Chapter 04Plant Responses to Exogenous Salicylic and Jasmonic Acids under Drought StressKazem Ghassemi-Golezani1*, Salar Farhangi-Abriz2Chapter 05Role of jasmonic acid and salicylic acid signaling in secondary metabolite production Samapika Nandy, Tuylee Das, Abhijit Dey*Chapter 06Role of jasmonates and salicylates in plant allelopathyAnam Asif1, Mohammad Affan Baig2*, M. Badruzzaman Siddiqui1Chapter 07Jasmonate: A versatile messenger in plantsPriyanka Singh, Yamshi Arif, Husna Siddiqui and Shamsul Hayat*Chapter 08The crucial role of jasmonates in enhancing heavy metals tolerance in plantsAli Raza1*, Sidra Charagh2, Shiva Najafi Kakavand3,4, Manzer H. Siddiqui5Chapter 09Jasmonates: The Fine-Tuning Bio-Regulators and their Crosstalk with Plant Reproductive BiologyDeepu Pandita*Chapter 10Role of Jasmonates in pathogenesis and crosstalk of Jasmonates with other hormonesShreshtha Yadav1, Simran1, Nisha Sella1, Shabir A. Rather2*Chapter 11Methyl Jasmonate and its Application for Improving Postharvest Quality of Fruits Deep Lata1, Anusree Anand1, Burhan Ozturk2, Riadh Ilahy3 , Md. Shamsher Ahmad4, and Mohammed Wasim Siddiqui4*Chapter 12Salicylic acid signalling under stress conditions in plantsTibor Janda*, Kinga O. Gondor, Magda Pál, Gabriella SzalaiChapter 13Function of Mediator in regulating salicylic acid mediated signaling and responses in plantsShubham Kumar Sinha, Koppolu Raja Rajesh Kumar*Chapter 14The Hidden Pathways Affecting Salicylic Acid Signaling in PlantsBahareh Hekmatdoust Tabrizi1, Neda Fattahi1, Rachel Backer2, Zahra Dehghanian3, Khosro Balilashaki4, Behnam Asgari Lajayer5*, and Tess Astatkie6 Chapter 15Salicylic Acid (SA): Its interaction with different molecules in the stress tolerance signaling pathwaysAparna Pandey1, Nidhi Verma1, Shikha Singh1, Gausiya Bashri2 and Sheo Mohan Prasad1*

Read more less

Book SynopsisThis book serves as the first comprehensive compilation describing the breeding strategies and genetics and genomics of the coconut palm. It describes gene evolution of economically important traits such as oil biosynthesis, aroma and fragrance, disease-resistant genes and small RNAs-mediated gene regulation of coconut. Application of “omics” approaches in palms and the prospects of genome editing technologies in coconut are also discussed. The author list includes pioneers and experts in the field of coconut genomics. The book appeals to postgraduate students, researchers and industry players in the field of plantation crops in general and coconut in particular.Table of ContentsChapter 1. World Economic Importance.- Chapter 2. Botanical Study and Cytology.- Chapter 3. Germplasm Resources: Diversity and Conservation.- Chapter 4. Breeding Strategies.- Chapter 5. Characterization of Genetic Diversity Using Molecular Markers.- Chapter 6. Quantitative Trait Loci (QTL) and Association Mapping for Major Agronomic Traits.- Chapter 7. Palms in an ‘OMICS’ Era.- Chapter 8. Genome Sequencing, Transcriptomics, Proteomics and Metabolomics.- Chapter 9. Mitochondrial and Chloroplast Genomes.- Chapter 10. Endosperm Oil Biosynthesis: A Case Study for Trait Related Gene Evolution in Coconut.- Chapter 11. Aroma and Fragrance: A Case Study for Trait-Related Gene Evolution in Coconut.- Chapter 12. Resistance Gene Candidates (RGCs) in Coconut Palm: A Molecular Platform for the Genetic Improvement of Resistance to Pathogens.- Chapter 13. Epigenetics of Coconut Endosperm Development.- Chapter 14. Genome Editing: Prospects and Challenges.- Chapter 15. Coconut: The Tree Of Life- Endless Possibilities.

Read more less

Book SynopsisThis book serves as the first comprehensive compilation describing the breeding strategies and genetics and genomics of the coconut palm. It describes gene evolution of economically important traits such as oil biosynthesis, aroma and fragrance, disease-resistant genes and small RNAs-mediated gene regulation of coconut. Application of “omics” approaches in palms and the prospects of genome editing technologies in coconut are also discussed. The author list includes pioneers and experts in the field of coconut genomics. The book appeals to postgraduate students, researchers and industry players in the field of plantation crops in general and coconut in particular.Table of ContentsChapter 1. World Economic Importance.- Chapter 2. Botanical Study and Cytology.- Chapter 3. Germplasm Resources: Diversity and Conservation.- Chapter 4. Breeding Strategies.- Chapter 5. Characterization of Genetic Diversity Using Molecular Markers.- Chapter 6. Quantitative Trait Loci (QTL) and Association Mapping for Major Agronomic Traits.- Chapter 7. Palms in an ‘OMICS’ Era.- Chapter 8. Genome Sequencing, Transcriptomics, Proteomics and Metabolomics.- Chapter 9. Mitochondrial and Chloroplast Genomes.- Chapter 10. Endosperm Oil Biosynthesis: A Case Study for Trait Related Gene Evolution in Coconut.- Chapter 11. Aroma and Fragrance: A Case Study for Trait-Related Gene Evolution in Coconut.- Chapter 12. Resistance Gene Candidates (RGCs) in Coconut Palm: A Molecular Platform for the Genetic Improvement of Resistance to Pathogens.- Chapter 13. Epigenetics of Coconut Endosperm Development.- Chapter 14. Genome Editing: Prospects and Challenges.- Chapter 15. Coconut: The Tree Of Life- Endless Possibilities.

Read more less

Book SynopsisThis book is the first comprehensive compilation of knowledge on teak biology, ecology, clonal forestry, clonal registration, seed biology, and seed orchards. The teak genetic diversity, the sequenced genome, and transcriptomes from different tissues and their implications in modern tree improvement and material selection have been comprehensively discussed. The book also presents a narrative on wood characterization, wood chemistry, modern silviculture, growth and modelling, and economics of this valued tropical species. Altogether, the book contains about 200 pages over 16 chapters authored by globally reputed experts on the relevant field in this tropical tree. This book is useful to students, teachers, and scientists, and wood-based industries are interested in forestry, biology, seed orchards, breeding, genetic diversity, molecular genetics, in vitro culture, wood chemistry, and structural and functional genomics.Table of Contents

Read more less

Book SynopsisThis book provides updated and all-inclusive data and evidences for Moringa botany, cytogenetical analysis, genetic resources and diversity, classical genetics, traditional breeding, tissue culture, genetic transformation, whole-genome sequencing, comparative genomics and elucidation on applications of functional genomics, nanotechnology, bioinformatics, processing and value addition besides providing perspectives of medicinal and therapeutic properties of Moringa. Moringa gained global attention in the recent past owing to its unique blend of affordable nutraceutical and pharmaceutical compounds in all parts of the plants. Scientific literatures supporting its health benefits besides the studies on its utility in various fields are scattered on several reports. This book is written by renowned global subject experts by compiling and narrating it in a sober style.Table of Contents

Read more less

Book SynopsisThis book is the first comprehensive compilation of the most up-to-date research in the genomics, transcriptomics, and breeding of pine species across Europe, North America, and Australia. With chapters on the state of the reference genomes, transposon function, genome-wide diversity, functional genomics, genomics of disease resistance, genomics of abiotic stress, and genomic selection, this book is a must-read for scientists, breeders, and students of plant genomics. The book contains 12 chapters over 300 pages authored by a group of world-renowned scientists in the field of pine genomics. Pines (Pinus) are the world’s most economically important forest tree species. The recent genome sequencing of several important pine species has paved the way for understanding their complex biology and helps future management and breeding efforts.Table of Contents

Read more less

Book SynopsisThis thorough introductory volume presents the background, applications, and stepwise directions for standard DNA and RNA isolation techniques. Unlike a kit chemistry approach, this book provides a breadth of information necessary for junior or non-expert researchers to learn and apply these techniques in their work. An accessible, indispensable how-to guide for researchers in immunology, molecular biology, zoology, forensic science, genetics, botany, neuroscience, physiology, and others.Table of Contents1-Basic idea about nucleic acids for non-experts 2-General steps during isolation of DNA and RNA 3-Phenol-chloroform DNA isolation method 4-RNA isolation by the guanidinium-acid-phenol method 5-Spin column-based isolation of nucleic acid 6-Isolation of plasmid DNA by alkaline lysis 7-DNA Isolation by Hydrophilic Ionic Liquid Treatment 8-Lithium Chloride based isolation of DNA and RNA 9-Isolation of Bacteriophage DNA by PEG Method 10-DNA isolation by Chelex Method 11-DNA isolation by Lysozyme and Proteinase K 12-Salting-out method for blood samples 13-CTAB or SDS based isolation of plant’s DNA 14-DNA extraction by spooling method 15-Magnetic bead-based nucleic acid isolation 16-Density gradient-based nucleic acid isolation 17-DNA extraction from agarose gel though paper-strips 18-TRANSFORMATION OR GENETIC MODIFICATION OF CELLS/ORGANISMS 19-GENE CLONING AND VECTORS 20-POLYMERASE CHAIN REACTION (PCR) 21-Southern and Northern Blotting 22-GENOME MAPPING 23-Applications of DNA Sequencing Technologies for Current Research

Read more less