Genetics (non-medical) Books

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Book SynopsisTrade Review"This book provides a comprehensive overview of genome stability that should be of great interest to any researcher within this area of expertise." --The Quarterly Review of Biology, Vol.92, No. 4Table of Contents1. Genome stability – an evolutionary perspective Igor Kovalchuk I. Genome Instability of Viruses 2. Genetic Instability of RNA Viruses John N. Barr and Rachel Fearns 3. Genome instability in DNA viruses Rafael Sanjuán, Marianoel Pereira-Gómez, Jennifer Risso II. Genome instability in Bacteria and Archaea 4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability Jan-Erik Messling and Ashley B. Williams 5. Genome instability in bacteria: causes and consequences Ashley B. Williams 6. CRISPR - bacteria immune system Andrey Golubov III. Genome Stability of Unicellular Eukaryotes 7. Programmed DNA rearrangement in ciliates Franziska Jönsson 8. Homologous Recombination and Non-homologous End-joining repair in yeast Rebecca E. Jones and Timothy C. Humphrey IV. Genome stability in multicellular eukaryotes 9. Meiotic and Mitotic Recombination: First in Flies Julie Korda Holsclaw, Talia Hatkevich and Jeff Sekelsky 10. Genome stability in Drosophila – mismatch repair and genome stability Tomoe Negishi 11. Genome stability in Caenorhabditis elegans Matthias Rieckher, Amanda Franqueira C. Lopes and Björn Schumacher 12. Genetic Engineering of Plants using Zn-fingers, TALENs and CRISPRs Andriy Bilichak and Francois Eudes 13. Plant Genome Stability – General Mechanisms Andriy Bilichak V. Genome stability in mammals 14. Cell cycle control and DNA damage signalling in mammals Valenti Gomez and Alexander Hergovich 15. The role of p53/p21/p16 in DNA damage signalling and DNA repair Yavuz Kulaberoglu, Ramazan Gundogdu, and Alexander Hergovich 16. Roles of RAD18 in DNA Replication and Post-Replication Repair (PRR) Cyrus Vaziri, Satoshi Tateishi, Liz Mutter-Rottmayer and Yanzhe Gao 17. Base Excision Repair and Nucleotide Excision Repair Tadahide Izumi and Isabel Mellon 18. DNA Mismatch Repair in Mammals Mingzhang Yang and Peggy Hsieh 19. Repair of double strand breaks by non-homologous end joining; its components and their function Patryk Moskwa 20. Double-Strand Break Repair: Homologous Recombination in Mammalian Cells Camille Gelot, Tangui Le-Guen, Sandrine Ragu and Bernard S. Lopez 21. Telomere maintenance and genome stability Wilnelly Hernandez-Sanchez, Mengyuan Xu and Derek J. Taylor 22. The relationship between checkpoint adaptation and mitotic catastrophe in genomic changes in cancer cells Lucy H. Swift and Roy M. Golsteyn 23. Chromatin, nuclear organization and genome stability in mammals Lora Boteva, Nick Gilbert 24. Role of DNA methylation in genome stability Dan Zhou and Keith D. Robertson 25. Non-coding RNAs in genome integrity Igor Kovalchuk VI. Human diseases associated with genome instability 26. Human diseases associated with genome instability Bruno César Feltes, Joice de Faria Poloni, Kendi Nishino Miyamoto and Diego Bonatto 27. Cancer and genomic instability Wei Wei, Yabin Cheng and Bo Wang 28. Chromatin Modifications in DNA Repair and Cancer Margaret Renaud-Young, Karl Riabowol and Jennifer Cobb 29. Genomic Instability and Aging – Causes and Consequences Corinne Sidler 30. Nucleolar contributions to DNA damage response and genomic (in)stability in the nervous system Michal Hetman VII. Effect of environment on genome stability 31. Diet and nutrition Lynnette R. Ferguson 32. Chemical mutagenesis 33. Environmental sources of ionizing radiation and their health consequences Aaron A. Goodarzi, Alexander Anikin, Dustin D. Pearson Section VIII. Bystander and transgenerational effects – epigenetic perspective 34. Epigenetics of transgenerational genome instability in mammals 35. Genomic Instability and the Spectrum of Response to Low Radiation Doses Carmel Mothersill and Colin Seymour 36. Transgenerational genome instability in plants Igor Kovalchuk 37. Methods for the detection of DNA damage Denis V. Firsanov, Ljudmila V. Solovjeva, Vyacheslav M. Mikhailov, Maria P. Svetlova 38. Conserved and divergent features of DNA repair. Future perspectives in genome instability research Igor Kovalchuk

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Book SynopsisTable of ContentsSection I. Genomics and the eye 1. Genetic disorders and genetic variants 2. Genetic testing techniques 3. Genetic variant interpretation 4. Genetic counselling and family support 5. Syndromic conditions and the eye 6. Ophthalmic phenotyping. Electrophysiology 7. Ophthalmic phenotyping. Imaging 8. Gene therapy and treatment trials Section II. Genetic disorders affecting the anterior segment 9. Genetic disorders affecting the cornea 10. Anterior segment developmental disorders 11. Cataract 12. Ectopia lentis Section III. Genetic disorders affecting the posterior segment 13. Genetic disorders affecting the retina, choroid and RPE 14. Familial vitreoretinopathies 15. Genetic disorders affecting the optic nerve Section IV. Genetic disorders affecting both the anterior and posterior segment 16. Developmental eye disorders 17. Aniridia 18. Albinism Section V. Genetic disorders affecting ocular motility 19. Infantile nystagmus 20. Congenital cranial dysinnervation disorders 21. Progressive external ophthalmoplegia Section VI. Tumour predisposition syndromes 22. Phakomatoses 23. Naevoid basal cell carcinoma syndrome 24. Congenital hypertrophy of retinal pigment epithelium (CHRPE) 25. Retinoblastoma

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Book SynopsisA compact guide to DNA: who we are, how we're wired, and how we repair ourselves. Table of ContentsMeet your genome • How do genes work? • Our genetic journey • Under attack! • Who do you think you are? • People are not peas • Genetic superheroes • Turn me on • Epigenetics • The RNA world • Building a baby • Wiring the brain • Compatibility genes • Why women are stripy • The viruses that made us human • When things go wrong • Human 2.0.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisHuman intelligence is sexually attractive, and strongly predicts the success of sexual relationships, but the behavioral sciences have usually ignored the interface between intelligence and mating. This is the first serious scholarly effort to explore that interface, by examining both universal and individual differences in human mating intelligence. Contributors include some of the most prominent evolutionary psychologists and promising new researchers in human intelligence, social psychology, intimate relationships, and sexuality.                        David Buss' foreword and the opening chapter explore what mating intelligence' means, and why it is central to human cognition and sexuality. The book's six sections then examine (1) our mating mechanisms universal emotional and cognitive adaptations for mating intelligently that guide mate search, mate choice, Trade Review"A wonderful collection of chapters on … the new construct of mating intelligence … [it] heralds a more comprehensive understanding of the psychology of human mating ... readers will enjoy the many mating insights offered by this volume." - David M. Buss, Ph.D., University of Texas at Austin, From the Foreword"Like many central areas of human behavior that have been neglected by mainstream psychology, the thoughts and emotions behind mating have recently been illuminated by evolutionary analyses. This exciting collection marks the debut of a new and important field of research, which should fascinate psychologists and nonpsychologists alike." - Steven Pinker, Johnstone Professor of Psychology, Harvard University"A significant contribution to the field, combining in one source, material on an interesting and important topic." - Dennis Krebs, Ph.D., Simon Fraser University"A ‘must have’ for scholars who do research on human mating …a unique volume of cutting edge thinking on the psychology of mating." - Timothy Ketelaar, Ph.D.,New Mexico State University“…A wonderful collection of chapters on … the new construct of mating intelligence… [it] heralds a more comprehensive understanding of the psychology of human mating…readers will enjoy the many mating insights offered by this volume.”—David M. Buss, Ph.D.University of Texas at Austin, From the Foreword“…A significant contribution to the field, combining in one source, material on an interesting and important topic.”—Dennis Krebs, Ph.D.Simon Fraser University“...A ‘must have’ for scholars who do research on human mating …a unique volume of cutting edge thinking on the psychology of mating.”—Timothy Ketelaar Ph.D.New Mexico State University"Like many central areas of human behavior that have been neglected by mainstream psychology, the thoughts and emotions behind mating have recently been illuminated by evolutionary analyses. This exciting collection marks the debut of a new and important field of research, which should fascinate psychologists and nonpsychologists alike."—Steven PinkerJohnstone Professor of Psychology, Harvard UniversityTable of ContentsPart 1. Introduction.D. Buss, Foreword. Preface. G. Geher, G. Miller, J. Murphy, Mating Intelligence: Towards an Evolutionarily Informed Construct. Part 2. Mate Search and Mating Intelligence.L. Penke, P.M. Todd, A.P. Lenton, B. Fasolo, How Self-assessments Can Guide Human Mating Decisions. C. De Backer, J. Braeckman, L. Farinpour, Mating Intelligence in Personal Ads. Part 3. Strategic Flexibility in Mating Intelligence.N. Li, Intelligent Priorities: Adaptive Long- and Short-Term Mate Preferences. D. Nettle, H. Clegg, Personality, Mating Strategies, and Mating Intelligence. M. O’Sullivan, Deception and Self-deception as Strategies in Short and Long-term Mating. V.A. Weekes-Shackelford, J.A. Easton, E.A. Stone, How Having Children Affects Mating Psychology. Part 4. Mental Fitness Indicators and Mating Intelligence.M.C. Keller, The Role of Mutations in Human Mating. A. Shaner, G. Miller, J. Mintz, Mental Disorders as Catastrophic Failures of Mating Intelligence. Part 5. Mating Intelligence and Other Individual Differences.S.B. Kaufman, A. Kozbelt, M.L. Bromley, G. Miller, The Role of Creativity and Humor in Mate Selection. J.J. Casey, J. Garrett, M.A. Brackett, S. Rivers, Emotional Intelligence, Relationship Quality, and Partner Selection. S. Kanazawa, Mating Intelligence and General Intelligence as Independent Constructs. Part 6. The Ecological Context of Mating Intelligence.J. Ash, G.G. Gallup, Jr., Brain Size, Intelligence, and Paleoclimatic Variation. A.J. Figueredo, B.H. Brumbach, D.N. Jones, J.A. Sefcek, G. Vásquez, W.J. Jacobs, Ecological Constraints on Mating Tactics. Part 7. Conclusions.G. Miller, Mating Intelligence: Frequently Asked Questions. G. Geher, M.A. Camargo, S. O’Rourke, Mating Intelligence: An Integrative Model and Future Research Directions.

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Book SynopsisDNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair Table of ContentsPreface Editors Contributors 1. Introduction John J. Reynolds, Roger J. A. Grand, and Martin R. Higgs2. DNA Replication and Cell Cycle Control Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus3. DNA Replication Termination and Genomic Instability Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus4. Mechanisms of DNA Damage Tolerance Cyrus Vaziri and Anastasia Zlatanou5. The Repair of DNA Single-Strand Breaks and DNA Adducts: Mechanisms and Links to Human Disease Alicja Winczura and John J. Reynolds6. Homologous Recombination at Replication Forks Eva Petermann7. Mechanism of Double-Strand Break Repair by Non-Homologous End Joining Michal Malewicz8. Protein Methylation and the DNA Damage Response Martin R. Higgs and Clare Davies9. Ubiquitin, SUMO and the DNA Double-Strand Break Response Ruth M. Densham, Alexander J. Garvin, and Joanna R. Morris10. Transcription in the Context of Genome Stability Maintenance Marco Saponaro11. RNA Binding Proteins and the DNA Damage Response Roger J. A. Grand12. DNA Replication and Inherited Human Disease John J. Reynolds and Grant S. Stewart13. Ataxia Telangiectasia and Ataxia Telangiectasia–Like Disorders A. Malcolm R. Taylor14. DNA Repair Mechanisms in Stem Cells and Implications during Ageing Rachel Bayley and Paloma Garcia15. Targeting Replication Stress in Sporadic Tumours Marwan Kwok and Tatjana Stankovic16. A Few of the Many Outstanding Questions John J. Reynolds and Roger J. A. GrandIndex

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Book SynopsisSince the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP, firmly establishing its role as a physiological mediator. Over the last ten years, still further roles have been discovered that relate to nitric oxide's unique ability to interact with and modify a wide variety of other molecules and regulators including glutathione, as well as macromolecules such as DNA and proteins. Nitric Oxide, Cell Signaling, and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide. A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous implications in the fields of biology anTrade Review“… is very timely, bringing readers up to date with various facets of the work being carried out. … For an in-depth discussion of certain aspects of nitric oxide in mammalian systems, this is a very good book to read, with the excellent referencing that will allow for expanded further reading. …” — John T Hancock, School of Biosciences, University of the West of England, U.K., in The Quartely Review of Biology, Vol. 81, December 2006Table of ContentsNitric Oxide Controls Cell Respiration by Reacting with Mitochondrial Complex IV. Mitochondrial Nitric Oxide Signaling in Synaptic Plasticity and Cell Death. Mitchondrial Nitric Oxide and Redox Signaling Modulation of Cell Behavior. Functions of Mitochondrial Nitric Oxide Synthase. Peroxynitrite: A Mediator of Nitric Oxide-Dependent Mitochondrial Dysfunction in Pathology. Modulation of Glucose Metabolism by Nitric Oxide in Astrocytes and Neurons. Nitric Oxide Cell Signaling Mediated by cGMP. Regulation of Cell Signaling by Protein Nitrosylation/Denitrosylation. Nitric Oxide and Caspase Activation. Signaling Effects of Peroxynitrite in Mammalian Cells. Nitric Oxide and Cell Signaling: Redox Regulation of Ras Superfamily GTPases. NO and the HIF-1 Transducing Systems. The Crosstalk between Nitric Oxide and Ceramide: Coordinate Interactions Among Signaling Pathways Regulating Cell Death, Survival, and Differentiation. Nitrosothiol Signaling and Gene Regulation in Pulmonary Pathophysiology. Nitric Oxide and Gene Expression. Nitric Oxide as a Modifier of Gene Expression. Nitric Oxide and Post-Transcriptional Control of Gene Expression. Nitric Oxide and Tumor Biology.

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Book SynopsisResearch data is expensive and precious, yet it is seldom fully utilized due to our ability of comprehension. Graphical display is desirable, if not absolutely necessary, for fully understanding large data sets with complex interconnectedness and interactions. The newly developed GGE biplot methodology is a superior approach to the graphical analysis of research data and may revolutionize the way researchers analyze data. GGE Biplot Analysis: A Graphical Tool for Breeders, Geneticists, and Agronomists introduces the theory of the GGE biplot methodology and describes its applications in visual analysis of multi-environment trial (MET) data and other types of research data. The text includes three parts: I) Genotype by environment interaction and stability analysis, II) GGE biplot and multi-environment trial (MET) data analysis, and III) GGE biplot software and applications in analyzing other types of two-way data. Part I presents a comprehensive but succinct treatment of genotypTable of ContentsGenotype-by-Environment Interaction. Stability Analyses in Plant Breeding and Performance Trials. Theory of Biplot. Introduction to GGE Biplot. Biplot Analysis of Multi-environment Trial Data. GGE Biplot Software-The Solution for GGE Biplot Analyses. Cultivar Evaluation Based on Multiple Traits. QTL Identification Using Biplots. Biplot Analysis of Diallel Data. Biplot Analysis of Host Genotype-by-Pathogen Strain Interactions. Biplot Analysis to Detect Synergism Between Genotypes of Different Species.

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Book SynopsisThe past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable scope are now being routinely solved in neuroscience and many other areas of biomedical research. The results of these studies, in turn, are having, and will continue to have, profound impact on experimental approaches and designs for manipulating genes, the genome, and model organisms as a means of gaining insights into nervous system functioning and complex behavior.Methods in Genomic Neuroscience provides newcomers and experienced researchers with a reference guide for applying powerful, state-of-the-art molecular genetic techniques to the study of neural and behavioral systems. It thereby provides a foundation by which data on gene eTable of ContentsGene-Environment Interaction and Complex Behavior. Current Perspectives on the Genetic Analysis of Naturally-Occurring Neurological Mutations in Mice. Conditional and Inducible Gene Targeting in the Nervous System. Functional Identification of Neural Genes. Studying Brain Development and Wiring Using a Modified Gene Trap Approach. N-Ethyl-N-Nitrosourea (ENU) Mutagenesis: Functional Analysis of the Mouse Nervous System and Behavior. DNA Arrays and Gene Expression Analysis in the Brain. DNA Microarrays and Human Brain Disorders. Full-Length cDNA Libraries: Reagents for Functional Studies of the Nervous System. Methods for Gene Delivery to Neural Tissue. Neural Stem Cells and Brain Repair. Statistical Methods to Discover Susceptibility Genes for Nervous System Diseases. Genetic Variation Analysis of Neuropsychiatric Traits.

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Book SynopsisThe literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions. Unique to this book are the disease-centered chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diTrade Review"As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge, techniques as well as informed speculation…The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."- From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006Table of ContentsGeneral Concepts. Cytokine Gene Polymorphisms. Polymorphic Cytokine Networks in Multifactorial Conditions.

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Book SynopsisThe cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book''s interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs.The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areaTable of ContentsIntroduction: The Role of Sex Chromosomes. Sex Chromosomes and Sex Determination in Amphibia. Sex Chromosomes and Sex Determination in Reptiles. Sex Chromosomes, Sex Determination, and Meiosis in Birds. Sex Chromosomes and Sex Determination in Mammals: The Monotremes. Sex Chromosomes in Metatherians (Marsupials). Sex Chromosomes in Eutherian Mammals: Gene Dosage Compensation. The XY Body and Partial Synapsis in Eutherian Mammals. Recombination in the XY Pair of Eutherian Mammals. Sex Chromosomes and Sex Determination in the Mouse. Developmental and Genetic Aspects of Sex Determination in the Mouse. Unusual Gonosomal Systems: Lemmings and Akodon Rodents. Human Sex Chromosomes. Sex Chromosomes and Sex Determination in Fishes. Sex Chromosomes and Specialized Recombination Patterns. Appendix: The Discovery of Partial Synapsis.

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Book SynopsisThe Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.

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Book SynopsisA Step-by-Step Guide to Present and Future Uses of Microarray TechnologyMicroarray technology continues to evolve, taking on a variety of forms. From the spotting of cDNA and the in situ synthesis of oligonucleotide arrays now come microarrays comprising proteins, carbohydrates, drugs, tissues, and cells. With contributions from microarray experts in both academia and industry, Microarray Methods and Protocols is a turn-by-turn roadmap through the processes necessary to perform a successful microarray experiment.This easy to use book addresses the fundamental aspects of preparing and processing microarrays and bead arrays, labeling, and detection. It also includes a detailed How it Works section that discusses the underlying principles of a number of techniques. Troubleshooting guides offer additional advice for the successful performance of more than 100 protocols in 10 chapters that cover work iTrade ReviewThe book will be useful for researchers in protein chemistry and biochemistry, molecular biologists, and teachers and students of medical schools and universities specializing in microarray methods.--Doctor of Biological Sciences, G. Ya. Wiederschain. Biochemsitry - Moscow. 2010, VOL 75, No 9,1182Table of ContentsIntroduction to Microarray Technologies. Nucleic Acid Sample Preparation. Solid-Phase Substrates for Nucleic Acid Microarrays. Protein Sample Preparation for Microarrays. Solid-Phase Chemistries for Protein Microarrays. Protein Microarrays: The Link between Genomics and Proteomics. Bead Arrays: An Introduction to Multiplexed Bead-Based Assays for Proteins. Carbohydrate Arrays. Lectin Microarrays. Printing Methods. Appendix A: Microarray Reagent, Materials, and Equipment Sources. Appendix B: Image Analysis. Index.

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Book SynopsisScientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms and software tools. Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review useful software, including discussions on key algorithms, comparative data, and download locations. The book discusses the use of early normalization techniques for new profiling methods and includes strategies for assessing the utility of various normalization algorithms. It presents the latest microarray innovations from companies such as Agilent, Affymetrix,Trade Review"Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases." – In Anticancer Research, July/August 2008, Vol. 28, No. 4ATable of ContentsA comprehensive analysis of the effect of microarray data preprocessing methods on differentially expressed transcript selection. Differentiation detection in microarray normalization. Preprocessing and normalization for affymetrix genechip expression microarrays. Spatial detrending and normalization methods for two-channel DNA and protein microarray data. A survey of cDNA microarray normalization and a comparison by k-NN classification. Technical variation in modeling the joint expression of several genes. Biological interpretation for microarray normalization selection. Methodology of functional analysis for omics data normalization. Exon array analysis for the detection of alternative splicing. Normalization of array CGH data. SNP array-based analysis for detection of chromosomal aberrations and copy number variations. Index.

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Book SynopsisSince the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics.The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lTrade ReviewPraise for the First Edition"I thoroughly enjoyed this book and have already had to retrieve it from my PhD students who are anxious to read it ...make sure your library has a copy!"—Journal of Chemical Technology and Biotechnology, Vol. 80, Issue 8, August 2005"[This book] is the first book dedicated solely to chemical genomics. It presents the most important research and developments in chemical genomics … The plentiful tables and figures are well-designed and effectively support the content. … highly recommended for academic and special libraries with relevant programs, and for research scientists in the field."—E-StreamsTable of ContentsUtilizing small molecules in chemical genomics: Toward high-throughput approaches. Development and application of novel analytical methods in lipidomics. From chemical genomics to chemical proteomics: The power of microarray technology. Genomic and proteomic biomarkers in the drug R&D process. Quo vadis biomedical sciences in the omics era: Toward computational biology and medicine. Novel chemogenomic approaches to drug design.

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Book SynopsisThis accessibly written book introduces readers to DNAone of the most important technologies for the manipulation of all forms of life, from simple bacteria to plants and animals. It also addresses the most important social, ethical, political, economic, and other issues raised by this form of technology.The great strides made in our understanding of the structure and function of DNA in recent decades have led to applying this invaluable knowledge to use in serving humanity. For example, recent discoveries in the field of genetic editing have created the potential for the creation of life forms de novo, a possibility that results in profound ethical issues for the human race that are just beginning to be discussed. What other positiveand potentially negativedevelopments are coming our way with continuing advancements in DNA research? DNA Technology: A Reference Handbook provides an up-to-date historical overview and general technical background to the topic as well as a broad inTrade ReviewThis edition maintains the organization of the original, with sections for background and history; problems, issues, and solutions; profiles of individuals and organizations; data and documents; an extensive annotated bibliography; and a chronology. It will be most helpful to students needing a solid scientific background and looking for multidisciplinary information on various DNA technologies and related controversies. For libraries that own the previous edition and support programs in biology, biomedical science, or forensic science, purchase of this updated edition is necessary because the technology is advancing so quickly. Summing Up: Recommended. High school through undergraduate students; general readers. * Choice *Table of ContentsPreface to the First Edition, Preface to the Second Edition, 1 Background and History, Introduction, Modifying Life: The Early History, The Birth of Genetics, The Road to DNA, The Structure of DNA, The Rise of Molecular Genetics, Recombinant DNA Technology, Cloning, Transgenic Plants and Animals, Practical Applications of Transgenic Organisms, Research, Pharmaceuticals, Agriculture, GM Products Resistant to Certain Pests, GM Products Resistant to Herbicides, GM Products with Nutritional Value or Other Benefits, Industry, Gene Therapy and Genetic Testing, Genetic Testing, Forensic DNA Testing, Recent Advances in DNA Technology, Conclusion, References, 2 Problems, Issues, and Solutions, Introduction, Forensic Science, DNA Databases, DNA Fingerprinting Worldwide, Low Copy Number DNA, Genetically Modified Organisms, The First Genetically Modified Animal: AquAdvantage Salmon, Public Opinion about GM Foods, Regulation of GM Crops and Food, Labeling of GM Foods, GM Foods in the European Union, Xenotransplantation, Pharming, Genetic Testing, Risks and Benefits, Issues of Privacy and Confidentiality, Regulation, Genetic Counseling, Gene Therapy, Trends in Gene Therapy, Regulations, Cloning, Therapeutic and Reproductive Cloning, Controversies about Cloning, Human Reproductive Cloning, Therapeutic Cloning, Regulations in the United States, Cloning Issues Worldwide, The Double-Edged Sword of CRISPR Technology, Conclusion, References, 3 Perspectives, Introduction, Optogenetics: Arpita Dave, Africans Using Autosomal DNA Testing to Find Distant Family Members: LaKisha David, Mandatory GMO Labeling Is the "Right to Be Deceived": Jon Entine, A Brave New World for CRISPR/Cas9: Scientific Limitations and Ethical Considerations: Rachele Hendricks-Sturrup, Genome Editing Opens Brave New World: Nerissa Hoglen, Finding a Face in the DNA: Clara MacCarald, CRISPR Controversies: Deirdre Manion-Fischer, Modified DNA for Targeted Therapeutics: Manish Muhuri, CRISPR and Beyond—What the Future Holds for Gene Editing: Sheila T. Yong, Forensic Use of DNA Technology: Jon Zonderman, 4 Profiles, Introduction, Accreditation Council for Genetic Counseling (ACGC), AgBioWorld, American Board of Genetic Counseling (ABGC), American Society of Bioethics and Humanities (ASBH), American Society of Gene and Cell Therapy (ASGCT), American Society of Human Genetics (ASHG), W. French Anderson (1936– ), Werner Arber (1929– ), Armed Forces DNA Identification Laboratory (AFDIL), Association of Forensic DNA Analysts and Administrators (AFDAA), Oswald Avery (1877–1955), Paul Berg (1926– ), Biotechnology Innovation Organization (BIO), Biotechnology Regulatory Services (BRS), Herbert Boyer (1936– ), California Certified Organic Farmer (CCOF), Center for Bioethics and Human Dignity (CBHD), 185 Center for Food Safety (CFS), Center for Genetics and Society (CGS), Center for Genomics and Public Health (CGPH), Erwin Chargaff (1905–2002), Emmanuelle Charpentier (1968– ), 189 Mary-Dell Chilton (1939– ), Coalition for Genetic Fairness (CGF), Stanley N. Cohen (1935– ), Council for Responsible Genetics (CRG), Francis Crick (1916–2004), Karl Deisseroth (1971– ), Jennifer Doudna (1964– ), European NGO Network on Genetic Engineering (GENET), Federal Bureau of Investigation (FBI), Food and Agriculture Organization (FAO), Rosalind Franklin (1920–1958), Genetic Alliance, Greenpeace, Woo-suk Hwang (1953– ), Innocence Project, Institute for Responsible Technology (IRT), International Bioethics Committee (IBC), International Biopharmaceutical Association (IBPA), International Centre for Genetic Engineering and Biotechnology (ICGEB), Sir Alec Jeffreys (1950– ), Gregor Mendel (1822–1884), Johannes Friedrich Miescher (1844–1895), Juan Francisco Martinez Mojica (1963– ), Kary Mullis (1944– ), National Human Genome Research Institute (NHGRI), National Society of Genetics Counselors (NSGC), Marshall Nirenberg (1927–2010), Non-GMO Project, Northwest Resistance against Genetic Engineering (NW RAGE), Office of Biotechnology Activities (OBA), Office of Public Health Genomics (OPHG), Organic Consumers Association (OCA), Ingo Potrykus (1933– ), Presidential Commission for the Study of Bioethical Issues, Hamilton O. Smith (1931– ), Robert A. Swanson (1947–1999), Dizhou Tong (1902–1979), Union of Concerned Scientists (UCS), U.S. Environmental Protection Agency (EPA), U.S. Food and Drug Administration (FDA), J. Craig Venter (1946– ), James Watson (1928– ), 5 Data and Documents, Introduction, Data, Table 5.1. Adoption of Genetically Engineered Crops in the United States, 1996–2015 (percentage of planted land, in acres), Table 5.2. Types of Genetically Engineered Corn and Cotton in the United States, 2000–2015 (percentage of planted land, in acres), Table 5.3. Number of Releases, Sites, and Constructs Authorized by Aphis for Evaluation, Table 5.4. Number of Releases of Genetically Engineered Varieties by APHIS, by Crop, as of September 2013, Table 5.5. Number of Releases Approved by APHIS by Gene Trait, to September 2013, Table 5.6. Institutions with Greatest Number of APHIS Permits for Genetically Engineered Crops, to September 2013, Table 5.7. CODIS Statistics for 15 Top States, as of February 2016, Documents, Daubert v. Merrell Dow Pharmaceuticals, Inc. (1993), Executive Order 13145 (2000), Regulations with Respect to Genetically Modified Foods: European Union (2003), Alaska State Law on Genetic Privacy (2004), Post-Conviction DNA Testing (2004), United Nations Declaration on Human Cloning (2005), Additional Protocol to the Convention on Human Rights and Biomedicine, Concerning Genetic Testing for Health Purposes (2008), Genetic Information Nondiscrimination Act (2008), Vermont Act 120 (GM Food Labeling) (2014), Rule 702. Federal Rules of Evidence (2015), Grocery Manufacturers Association, et al. v. William H. Sorrell, et al. Case No. 5:14-cv-117 (2015), People v. Collins; NY Slip Op 25227 [49 Misc 3d 595] (2015), Collection and Use of DNA Identification Information from Certain Federal Offenders 42 U.S. Code § 14135a (2016), Issues of DNA Collection, Maryland v. King 569 U.S. ___, State v. Medina, et al. 2014 VT 69 (2014), 6 Annotated Bibliography, 7 Chronology, Glossary, Index, About the Author,

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Book SynopsisRice has been chosen as a model cereal for functional genomics because of its well understood genetics. In addition, there is great similarities among all the cereals and grasses: any understanding of rice genes is directly applicable to the genes of other cereals.Trade ReviewFrom the reviews: "This book represents an excellent set of (reviewed) reviews that explains what is happening in the world of rice genomic research now. … This is a useful book for genetic resources workers because understanding the way in which the genome works is generating huge numbers of mutants required for forward (from phenotype to genome sequence) and reverse genetics (genome sequence to phenotype)." (D. Vaughan, Genetic Resources and Crop Evolution, Vol. 54, 2007)Table of ContentsRice Genome Sequence: The Foundation for Understanding the Genetic Systems.- Rice Genome Annotation: Beginnings of Functional Genomics.- Genome-Wide RNA Expression Profiling in Rice.- Rice Proteomics: A Step Toward Functional Analysis of the Rice Genome.- Metabolomics: Enabling Systems-Level Phenotyping in Rice Functional Genomics.- Use of Naturally Occurring Alleles for Crop Improvement.- Chemical- and Irradiation-Induced Mutants and TILLING.- T-DNA Insertion Mutants as a Resource for Rice Functional Genomics.- Transposon Insertional Mutants: A Resource for Rice Functional Genomics.- Gene Targeting by Homologous Recombination for Rice Functional Genomics.- RNA Silencing and Its Application in Functional Genomics.- Activation Tagging Systems in Rice.- Informatics Resources for Rice Functional Genomics.- The Oryza Map Alignment Project (OMAP): A New Resource for Comparative Genome Studies within Oryza.- Application of Functional Genomics Tools for Crop Improvement.- From Rice to Other Cereals: Comparative Genomics.

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Book SynopsisThis book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic gene networks. Based on the system theory, some design specifications are provided to engineer the synthetic gene networks to robustly track the desired trajectory by employing the component libraries. Table of ContentsGeneral introduction. Survey of synthetic gene networks. Experimental techniques for engineering synthetic gene networks. Mathematical models and design specifications in synthetic gene networks. Robust synthetic biology designs based on system dynamic methods. Construction of promoter library and RBS library for synthesis of gene networks. Robust synthetic gene network designs based on library-search method. Next-generation synthetic gene network.

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Book SynopsisThe present work is an attempt to provide a systematic treatment of genetic linkage in diploid heredity. A large proportion, if not the majority, of mutant genes fail to match up to 'textbook' genes-with faultless segregation ratios and expression-yet, these are the materials with which the practical researcher has to cope.Table of Contentsof Part A.- A: The Biometrical Approach.- 1 Introduction.- 2 Maximum Likelihood Estimation.- 3 Inviability, Impenetrance and Linkage Detection.- 4 Estimation with Normal Gene Ratios.- 5 Estimation with Inviability.- 6 Estimation with Impenetrance.- 7 Estimation with Inviability and Impenetrance.- 8 Scoring.- 9 Multi-point Crosses.- 10 Mapping Functions.- 11 General Bibliography.- Index of Part A.

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Book SynopsisOut of the study of the intricacies of the genome and gene regulation, arose a new science that was independent of actual DNA changes, but critical in maintaining gene regulation and genetic stability.Trade ReviewFrom the reviews:“The book by Kovalchuk and Zemp is a successful attempt to provide the most recent approaches for identifying epigenetic variation in plants. … it is without doubts that the publication should be in every bookcase of molecular scientists interested in epigenetics. I can also recommend it for plant ecologists and evolutionists engaged in epigenetic variation in plants because some methods can be a good improvement of the currently commonly used approaches.” (Vit Latzel, Folia Geobotanica, Vol. 48, 2013)Table of ContentsTable of Contents Preface Contributors Analysis of DNA Methylation in Plants by Bisulfite Sequencing Andrea M. Foerster and Ortrun Mittelsten Scheid Analysis of bisulfite sequencing data from plant DNA with CyMATE Andrea M. Foerster, Jennifer Hetzl, Christoph Müllner and Ortrun Mittelsten Scheid Analysis of locus-specific changes in methylation patterns using a COBRA (combined bisulfite restriction analysis) assay Alex Boyko and Igor Kovalchuk Detection of changes in global genome methylation using the cytosine-extension assay Alex Boyko and Igor Kovalchuk In situ analysis of DNA methylation in plants Palak Kathiria and Igor Kovalchuk Analysis of mutation/rearrangement frequencies and methylation patterns at a given DNA locus using RFLP (restriction fragment length polymorphism) Alex Boyko and Igor Kovalchuk Isoschizomers and Amplified Fragment Length Polymorphism (AFLP) for the Detection of Specific Cytosine Methylation Changes Leonor Ruiz-García, Jose Antonio Cabezas, Nuria de María, María-Teresa Cervera Analysis of small RNA populations using hybridization to DNA tiling arrays Martine Boccara, Alexis Sarazin, Bernard Billoud, Agnes Bulski, Louise Chapell, David Baulcombe and Vincent Colot Northern blotting techniques for small RNAs Todd Blevins qRT-PCR of small RNAs Erika Varkonyi-Gasic and Roger P. Hellens Cloning new small RNA sequences Yuko Tagami, Naoko Inaba and Yuichiro Watanabe Genome-wide Mapping of Protein-DNA Interaction by Chromatin Immunoprecipitation and DNAMicroarray Hybridization (ChIP-chip). Part A – ChIP-chip Molecular Methods Julia J. Reimer and Franziska Turck Genome-wide mapping of protein-DNA interaction by chromatin immunoprecipitation and DNA microarray hybridization (ChIP-chip). Part B – ChIP-chip data analysis Ulrike Göbel and Franziska Turck Metaanalysis of ChIP-chip data Julia Engelhorn and Franziska Turck Chromatin Immunoprecipitation Protocol for Histone Modifications and Protein-DNA Binding Analyses in Arabidopsis Stéphane Pien, Ueli Grossniklaus cDNA Libraries for Virus-Induced Gene Silencing Andrea T. Todd, Enwu Liu and Jonathan E. Page Detection and quantification of DNA strand breaks using the ROPS (random oligonucleotide primed synthesis) assay Alex Boyko and Igor Kovalchuk Reporter gene-based recombination lines for studies of genome stability Palak Kathiria and Igor Kovalchuk Plant transgenesis Alicja Ziemienowicz

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Book SynopsisLong regarded as biological waste, the placenta is gaining momentum as a viable product for clinical use. Due to their unique properties, placental cells and derivatives show great promise in curing various diseases. Utilizing contributions from world-renowned experts, Placenta: The Tree of Life considers the therapeutic potential of these cells. It examines new stem cellbased strategies and highlights recent studies that advance the range of treatment for a number of illnesses. Emphasizing the potential research and therapeutic use of stem cells, the book discusses the development, structure, and functions of the human placenta. It introduces overall aspects of the immune system, explains some of the immune mechanisms during pregnancy, and shows the role of the placenta in these mechanisms. Current scientific research is presented that focuses on the mechanisms of action underlying the therapeutic benefit of cells isolated from different placental regionTable of ContentsStructure and Development of the Human Placenta. The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. The Roles of the Human Placenta in Fetal-Maternal Tolerance. The Human Placenta in Wound Healing: Historical and Current Approaches. Cell Populations Isolated from Amnion, Chorion, and Wharton’s Jelly of Human Placenta. The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi: In Vitro and In Vivo Data. Use of Placenta-Derived Cells in Neurological Disorders. Use of Amnion Epithelial Cells in Metabolic Liver Disorders. The Use of Placenta-Derived Cells in Autoimmune Disorders. The Use of Placenta-Derived Cells in Inflammatory and Fibrotic Disorders. From Bench to Bedside: Strategy, Regulations, and Good Manufacturing Practice Procedures. Applications of Placenta-Derived Cells in Veterinary Medicine.

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Book SynopsisThe scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.Table of ContentsCilia in the Brain – Development and Disease. Cilia in Lung Development and Disease. The Role of Cilia in Heart Development and Disease. Cilia in Kidney Development and Disease. The Role of Cilia in Pancreatic Development and Disease. The Role of Cilia in Skeletal Development and Disease. The Role of Cilia in Development and Disease of the Eye. The Role of Cilia in the Auditory System.

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Book SynopsisAlthough books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.Table of ContentsIntroduction. Hormesis. The Diverse Demography of Aging. Aging is not caused by accumulated damage. Three Prevailing Theories, and Their Failings. Aging is Very Old. Population Control. How Might Aging Have Evolved as an Adaptation? Implications and Directions. A New Paradigm for Medical Research.

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Book SynopsisIt was not until recent years that the study of polyamines, their mechanisms of synthesis, and the roles they play in metabolism have flourished, becoming a fertile field of intense research. Polyamines in Fungi: Their Distribution, Metabolism, and Role in Cell Differentiation and Morphogenesis provides a complete overview of its topic. It is the first and only book to describe and analyze the roles of polyamines in fungi and compare them with the roles of polyamines in higher eukaryotes. The book contains data on the distribution of polyamines, their physiological functions, mechanism of synthesis and regulation, phylogenetic analyses of the enzymes involved in their synthesis, their use as possible targets for the control of fungal diseases, and possible biotechnological and medical applications.Based on work generated by the authors in their laboratory over many years, the book contains all the basic information to understand the similaritTable of ContentsIntroduction. Chemistry and Cellular Localization of Polyamines. Mechanisms of Polyamines Biosynthesis, Their Interconversion and Degradation in Fungi, in Comparison with Animal and Plant Cells. Polyamine Distribution in the Fungal Kingdom, as Compared with Other Eukaryotic Organisms. Regulatory Mechanisms of Polyamine Metabolism at the Transcriptional, Translational, and Post-translational Levels in Fungi and Other Organisms. General Functions of Polyamines and Their Possible Modes of Action in Fungi and Other Organisms. The Role of Polyamines on Cell Differentiation and Morphogenesis in Fungi and Other Organisms. Polyamine Metabolism as a Target.

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Book SynopsisApplied Mathematics and Omics to Assess Crop Genetic Resources for Climate Change Adaptive Traits focuses on practical means and approaches to further the use of genetic resources for mitigating the effects of climate change and improving crop production. Genetic diversity in crop plants is being further explored to increase yield, disease resistance, and nutritional value by employing recent advances in mathematics and omics technologies to promote the adaptation of crops to changing climatic conditions.This book presents a broad view of biodiversity and genetic resources in agriculture and provides answers to some current problems. It also highlights ways to provide much-needed information to practitioners and innovators engaged in addressing the effects of global climate change on agriculture. The book is divided into sections that cover: The implications of climate change for drylands and farming communities The potential of genetic resTable of ContentsCLIMATE-CHANGE IMPLICATIONS FOR DRYLANDS AND FARMING COMMUNITIES. Climate Change and Dryland Systems. Plant Genetic Resources and Climate Change: Stakeholder Perspectives from the Nordic and Arctic Regions. Adaptation of Farmers to Climate Change: A Systems Approach to Cereal Production in Benslimane Region, Morocco. Assessment of the Demand–Supply Match for Agricultural Innovations in Africa. POTENTIAL OF USING GENETIC RESOURCES AND BIODIVERSITY TO ADAPT TO AND MITIGATE CLIMATE CHANGE. Exploitation of Genetic Resources to Sustain Agriculture in the Face of Climate Change with Special Reference to Wheat. Utilizing the Diversity of Wild Soybeans in China for Accelerating Soybean Breeding in the Genome Era. Adaptation of Potato (Solanum tuberosum) and Tomato (S. lycopersicum) to Climate Change. Barley Genetic Resources for Climate-Change Adaptation: Searching for Heat-Tolerant Traits through Rapid Evaluation of Subsets. Fruit Genetic Resources Facing Increasing Climate Uncertainty. APPLIED MATHEMATICS (UNLOCKING THE POTENTIAL OF MATHEMATICAL CONCEPTUAL FRAMEWORKS). Applied Mathematics in Genetic Resources: Toward a Synergistic Approach Combining Innovations with Theoretical Aspects. Power Transformations: Application for Symmetrizing the Distribution of Sample Coefficient of Variation from Inverse Gaussian Populations. Toward More Effective Discovery and Deployment of Novel Plant Genetic Variation: Reflection and Future Directions. Identifying Climate Patterns during the Crop-Growing Cycle from 30 Years of CIMMYT Elite Spring Wheat International Yield Trials. Assessing Plant Genetic Resources for Climate-Change Adaptive Traits: Heat Traits. Plant Genetic Diversity: Statistical Methods for Analyzing Distribution and Diversity of Species. APPLIED OMICS TECHNOLOGIES. Exploiting Germplasm Resources for Climate-Change Adaptation in Faba Bean. Developing Climate-Change Adaptive Crops to Sustain Agriculture in Dryland Systems through Applied Mathematics and Genomics. Toward the Rapid Domestication of Perennial Grains: Developing Genetic and Genomic Resources for Intermediate Wheatgrass. Traits for Testing, Screening, and Improving Salt Tolerance of Durum Wheat Genetic Resources. Gene Flow as a Source of Adaptation of Durum Wheat to Changing Conditions Including Climate Change: Double Gradient Selection Technique. Addressing Diversity of Ethiopian Durum Wheat Landrace Populations Using Microsatellite Markers.

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Book SynopsisMany of our current agricultural crops are natural or agricultural hybrids (between two or more species), or polyploids (containing more than one genome or set of chromosomes). These include potato, oats, cotton, oilseed rape, wheat, strawberries, kiwifruit, banana, seedless watermelon, triticale and many others. Polyploidy and hybridization can also be used for crop improvement: for example, to introgress disease resistance from wild species into crops, to produce seedless fruits for human consumption, or even to create entirely new crop types. Some crop genera have hundreds of years of interspecific hybridization and ploidy manipulation behind them, while in other genera use of these evolutionary processes for crop improvement is still at the theoretical stage. This book brings together stories and examples by expert researchers and breeders working in diverse crop genera, and details how polyploidy and hybridization processes have shaped our current crops, how these processes havTable of ContentsInterspecific Hybridization For Upland Cotton Improvement. Allopolyploidy and Interspecific Hybridization for Wheat Improvement. Potato Breeding through Ploidy Manipulations. Polyploid Induction Techniques and Breeding Strategies in Poplar. Musa Interspecific Hybridization and Polyploidy for Breeding Banana and Plantain (Musaceae). Strawberry (Plants in the Genus Fragaria). The role of polyploidization and interspecific hybridization in the breeding of ornamental crops. Polyploidy in maize: The impact of homozygosity and hybridity on phenotype. Broadening the genetic basis for crop improvement: Interspecific hybridization within and between ploidy levels in Helianthus. Crop Improvement of Phaseolus spp through Interspecific and Intraspecific Hybridization. Triticale. Polyploidy and Interspecific Hybridization in Cynodon, Paspalum, Pennisetum, and Zoysia. Interploid and Interspecific Hybridization for Kiwifruit Improvement. Oat Improvement and Innovation Using Wild Genetic Resources (Poaceae, Avena spp.): Elevating "Oats" to a New Level and Stature. Interspecific hybridization of chestnut. Use of Polyploids, Interspecific, and Intergeneric Wide Hybrids in Sugar Beet Improvement. Polyploidy in Watermelon. Optimization of recombination in interspecific hybrids to introduce new genetic diversity into oilseed rape (Brassica napus L.). Interspecific Hybridization for Chickpea (Cicer arietinum L.) Improvement.

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Book SynopsisWhile the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled with the fact that 60 percent of current drugs are based on targeting this group of proteins, a trend that does not seem likely to reverse.Structural Genomics on Membrane Proteins provides an excellent overview on novel research in bioinformatics and modeling on membranes, as well as the latest technological developments being employed in expression, purification, and crystallography to obtain high-resolution structures on membrane proteins. This cutting-edge work also explains the difficulties facing researchers—both technical and ethical—that have slowed the process. Structural Genomics on Membrane Proteins provides researchers with an unprecedented look at the novel technologies that will ultimately allow them to conquer the last frontier in structural biology, leading to accelerated breakthroughs in drug discovery.Table of ContentsIntroduction. Bioinformatics in Membrane Protein Analysis. Prokaryotic Membrane Transport Proteins: Amplified Expression and Purification. Membrane Protein Production Strategies for Structural Genomics. Refolding of Membrane Proteins for Large-scale Production. Crystallization of Membrane Proteins. Signaling through Membrane Proteins. Expression of Membrane Proteins in Yeasts. Expression of Functional Membrane Proteins in the Baculovirus-Insect Cell System: Challenges and Developments. Expression of Membrane Proteins in Mammalian Cells, Solubilization and Purification of Membrane Proteins. Fluorescent Labeling of Membrane Proteins in Living Cells. Membrane Protein NMR. Miniaturization of Structural Biology Technologies: From Expression to Biophysical Analyses. Electron and Atomic Force Microscopy of Reconstituted Membrane Proteins. Structural Genomics on Membrane Proteins. Molecular Modeling of Membrane Proteins. Towards Structural Bases for GPCR Ligand-binding: A Path for Drug Discovery.

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Book SynopsisDemonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs).The book begins with discussions on key HMM and related profile methods, including the HMMER package, the sequence analysis method (SAM), and the PSI-BLAST algorithm. It then provides detailed information about various types of publicly available HMM databases, such as Pfam, PANTHER, COG, and metaSHARK. After outlining ways to develop and use an automated bioinformatics workflow, the author describes how to make custom HMM databases using HMMER, SAM, and PSI-BLAST. He also helps you select the right program to speed up searches. The final chapter explores several applications of HMM methods, including predictions of subcellular localization, posttranslational modification, and binding site. By learning how to effectively use the databases and methods presented in this handbook, you will be able to efficiently identify features of biological interest in your data.Table of ContentsIntroduction to HMMs and Related Profile Methods. Profile HMMs.HMM Methods.HMM Databases.Building an Analytical Pipeline. Building Custom Databases. Speeding Your Searches.Other Uses of HMMs in Bioinformatics. Index.

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Book SynopsisOffering a summary of the current state of knowledge in autism research, Defining Autism looks at the different genetic, neurological and environmental causes of, and contributory factors to autism. It takes a wide-ranging view of developmental and genetic factors, and considers autism's relationship with other conditions such as epilepsy. Shedding light on the vast number of autism-related syndromes which are all too often denied adequate attention, it shows how, whilst autism refers to a single syndrome, it can be understood as many different conditions, with the common factors being biological, rather than behavioral.Table of Contents1. Kanner's Conundrum & Bernie's Biology. 2. The Brain in Autism. 3. The Genetics of Autism. 4. The Roles Environment Plays in Autism Susceptibility. 5. Regression in Autism. 6. Autism & Epilepsy. 7. The Neurodevelopmental Spectrum - Mental Health for the 21st Century. 8. The Broader Autism Phenotype. 9. Autism, Intellectual Disability & Genius. 10. Defining Autism.

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Book SynopsisThis book focuses on the application of behaviour genetic approaches to twin studies, and reviews diagnostic to Attention Deficit Hyperactivity Disorder (ADHD), the relationships between reading, spelling and ADHD, and family and genetic influences on speech and speech and language.Table of Contents1. Introduction 2. Introduction to the genetic analysis of attentional disorders 3. The diagnostic genetics of ADHD symptoms and subtypes 4. The developmental genetics of ADHD 5. Familial and genetic bases of speech and language disorders 6. Comorbidity of reading/spelling disability and ADHD 7. Causes of the overlap among symptoms of ADHD, Oppositional Defiant Disorder, and Conduct Disorder 8. Aetiology of the sex difference in the prevalence of DSM-III-R ADHD: A comparison of two models 9. Single gene studies of ADHD 10. Molecular genetics of ADHD 11. The genetic relationship between ADHD and Gilles de la Tourette syndrome 12. Implications of genetic studies of attention problems for education and intervention 13. Child psychiatry in the era following sequencing the genome

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Book SynopsisInternationally acclaimed science writer Lone Frank swabs up her DNA to provide the first truly intimate account of the new science of consumer-led genomics. She challenges the business mavericks intent on mapping every baby's genome, ponders the consequences of biological fortune-telling, and prods the psychologists who hope to uncover just how much or how little our environment will matter in the new genetic century - a quest made all the more gripping as Frank considers her family's and her own struggles with depression.Trade Review"A probing biological memoir… Refreshing [and] wonderfully poetic." * Publishers Weekly *"Readers will be intrigued by Frank's witty, engaging account of the possibilities of emerging genetic sciences as well as her thoughtful considerations of the philosophical and ethical dimensions of the widespread use of genetic data." * Library Journal *"My Beautiful Genome covers some of the most interesting controversies in biology today, including designer babies, brain imaging, and even whether or not we have free will. It's an enthralling read." * New Scientist *"The huge research effort to understand the complexity of the genome is throwing up new insights into the nature of humanity, as the Danish science writer Lone Frank shows in My Beautiful Genome, her excellent look into the postgenomic world…. Fascinating." * Financial Times *"A fascinating exploration of a subject that is not going to go away -- the influence of our genes on the way we are both medically and socially… Frank's light style and storytelling verve… make this an enjoyable read." Brian Clegg * PopularScience.co.uk *"It’s not often you can wholeheartedly recommend a book… but this is it." * Daily Mail *"A pin-sharp, lively memoir-cum-investigation… Frank's discoveries make for some truly tingling moments." * The Mail on Sunday *"The story of DNA told through one woman's quest to find out if the secret to her depression lies in her genes… A must-read." * BioNews *"Packed with juicy informative nuggets … weird, wonderful and very funny." * Independent on Sunday *“I thoroughly enjoyed this book and would not hesitate to recommend it as both a personal and a book group read.” * New Books *

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Book SynopsisRecent years have seen rapid advances in our understanding of genetic diseases in terms of their molecular origins. The book focuses on DNA mutations which give rise to abnormalities of protein structure and function in genetic disease. Trade Review"There are excellent chapters on many other disorders arising from dysfunctional proteins, which are all good descriptors of molecular and cellular mechanisms of disease." ; "Anyone interested in biology or human medicine would greatly benefit from readiTable of ContentsMutation and Protein Dysfunction; Haemoglobin: Glucose 6-phosphate Dehydrogenase; Glycogen Storage disease due to Phosphorylase Kinase Deficiency; The Retinoblastoma Tumour Suppressor Protein and Cancer; Rhodopsin Mutations in Photoreceptor Degeneration:

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Book SynopsisApoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.Table of ContentsSECTION I: MOLECULAR BIOLOGY OF APOPTOSIS. Ch 1. Death receptors in apoptosis, R. Ravi and A. Bedi both at The Johns Hopkins University School of Medicine, Baltimore, USA. Ch 2. The role of caspases in apoptosis, S. Kumar and D. Cakouros, both at Hanson Centre for Cancer Research, Adelaide, Australia.Ch 3. Making sense of the Bcl-2 family of apoptosis regulators, L. Haughn and D. Hockenbery both at Fred Hutchinson Cancer Research Center, Seattle, USA. Ch 4. Functional domains in apoptosis proteins, K. Hofmann, Memorec Stoffel GmbH, Cologne, Germany. SECTION II: CELL BIOLOGY OF APOPTOSIS.Ch 5. The role of the endoplasmic reticulum in apoptosis, D.G. Breckenridge and G. C. Shore both at McGill University, Montreal, Canada. Ch 6. Mitochondria in apoptosis induction, B. Antonsson Serono Pharmaceutical Research Institute, Geneva, Switzerland.SECTION III: CELL DEATH IN MODEL SYSTEMS. Ch 7. Regulators and applications of yeast apoptosis, K-U. Fröhlich IMBM, Graz, Austria and Frank Madeo, Universität Tubingen, Germany.Ch 8. Evolution of cell death: caspase mediated mechanisms in early metazoans. non-caspase mechanisms in single- celled eukaryotes, A. Böttger and C. David, University of Munich, Germany.Ch 9. Programme cell death in C. Elegans, A. Gartner, A. Alpi and B. Schumacher all at Max-Planck-Institute for Biochemistry, Martinsried, Germany. Ch 10. Apoptosis in Drosophilia, K. White Massachusetts General Hospital, Charlestown, USA. Ch 11. Cell culture systems in apoptosis, S. Grimm Max-Planck-Institute for Biochemistry, Martinsried, Germany. Ch 12. Caspase-independent cell death, M. Leist and Marja Jäättela H. Lundbeck A/S, Copenhagen-Valby, Copenhagen, Denmark and Denmark Institute for Cancer Biology, Copenhagen, Denmark.

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Book SynopsisThe story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.Trade Review"This book containing a wealth of information, has been written by the most competent author..I have no doubt that this book is masterfully written and excellently organised, it will serve as an encyclopaedic source of information". Human Genetics 200Table of ContentsPart 1. Introduction and Overview. 1. Structure and Function in the Human Genomes. 2. Evolution of the Human Genomes. Part 2. Evolution of Gene Structure. 3. Introns, Exons and Evolution. 4. Genes and Gene Families. 5. Promoters and Transcriptions Factors. 6. Pseudigenes and their Formation. Part 3. Mutational Mechanisms in Evolution. 7. Single Base-pair Substitutions. 8. Contractions and Expansions in Gene Size and Number. 9. Genes and Rearrangements. 10. Molecular Reconstruction of Ancient Genes/Proteins.

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Book SynopsisDistinguished scientists provide an overview of the molecular pathology of human disease. Each chapter provides an analysis of the molecular biological approaches to individual diseases, such as leukaemia, cardiovascular disease and cancer, and includes aTrade Review"..the editor should be complimented for the extent to which the unifying theme of employing genetic knowledge towards therapy has inspired the authors." FEBS LettersTable of ContentsWhat is molecular pathology? D.S. Latchman; Apolipoprotein B and coronary heart disease, J. Scott; Prospects for gene therapy of X-linked immunodeficiency diseases, C. Kinnon; Duchenne muscular dystrophy, S.C. Brown and G. Dickson; Molecular genetics of l

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Book SynopsisPopulation genomics is a rapidly emerging field that has the potential to transform our understanding of how evolutionary forces shape genomic diversity among microbes. There have already been considerable advances in understanding gene flow and spread of adaptive traits, and in linking epidemiology with evolutionary biology. The current challenge is to find unifying evolutionary principles for organisms that display a wide range of reproductive biology – from highly clonal to promiscuous – and for which the vast majority have eluded cultivation. This requires interdisciplinary approaches that incorporate novel computational tools, testing of existing and novel population genetic models, and creative new ways of linking genetic diversity to ecological factors. This pioneering book will discuss the advances made and promises of population genomics in microorganisms, outlining some of the key theoretical and practical challenges for microbial population genomics, including defining and identifying populations, genomics-based reverse ecology and building appropriate tools to understand microbes in a variety of complex environments.Table of ContentsPrefaceI. Concepts and perspectives1. Microbial Population Genomics Perspectives and Promises Martin Polz, MITOm Rajora, Umiversity of New Brunswick2. Population Genomics and Microbial Species Concept Jesse Shapiro, University of Montreal3. Population Genomics and Metagenomics Jill Banfield, University of California BerkeleyVincent Denef, University of Michigan4. Reverse Ecology Martin Polz, MIT5. Genomic and Computational Methods in Microbial Population GenomicsXavier Didelot, Imperial CollegeDaniel Falush, Swansea UniversityEric Alm, MITII. Population Genomics of Bacteria 6. Population Genomics of Plant Pathogenic Bacteria David Guttman, University of TorontoBoris Vinatzer, Virginia Tech7. Population Genomics of Human Pathogenic Bacteria Bill Hanage, Harvard School of Public HealthEd Feil, University of BathNick Croucher, Imperial College8. Population Genomics of Symbiotic Bacteria Nancy Moran, University of Texas, Austin9. Population Genomics of Dairy Industrial Bacteria Paul W. O’Toole, University College, CorkPaola Cremonesi, NRC, Italy10. Population Genomics of Environmental Bacteria and Archaea Rachel Whitaker, University of Illinois, Urbana-ChampaignDaniel Buckley, Cornell UniversityThane Papke, University of ConnecticutFrancisco Rodriguez-Valera, University Miguel HernandezIII. Population Genomics of Fungi11. Population Genomics of Plant Pathogenic Fungi Michael G. Milgroom, Cornell University 12. Population Genomics of Human Pathogenic Fungi Bruce McDonald, ETH Zurich Institute of Integrative Biology13. Population Genomics and Yeast Biodiversity and Evolution Cletus P Kurtzman, USDA ARSGianni Liti, Institute of Genetics, University of Nottingham Mathew R. Goddard, University of Auckland, University of Lincoln14. Population Genomics of Domestication in Yeast Edward J. Louis, Institute of Genetics, University of Nottingham;José Paulo Sampaio, Universidade Nova de Lisboa, Caparica, PortugalIV. Population Genomics of Viruses 15. Population Genomics of Human Viruses Richard A. Neher, Max Planck Institute of Developmental BiologyFrancois Balloux, University of Cambridge16. Population Genomics of Plant Viruses Zhongguo Xiong, University of ArizonaH.C. Prasanna, Indian Institute of Vegetable Research17. Population Genomics of Bacterial Viruses Mathew Sullivan, University of Ohio18. Population Genomics of Insect Viruses Robert S. Cornman, Bee Research Lab, USDA-ARSClement Gilbert, Universite de PoitiersIndex

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Book SynopsisThe first unequivocal success for Gene Therapy was reported in April 2000 for X-SCID patients. Pioneering stem cell/gene therapy clinical trials are the focus of this book. Therapy successes such as the X-SCID trial and improved ADA-SCID ones are presented together with pioneering angio/vasculogenic clinical trials mediated either by transient gene therapy or emerging autologous stem cell transplantation. Highlights also include 1) promises of the breakthrough combination of stem cell- and transient gene-therapy, 2) gene therapy trials for neurodegenerative disease on non-human primates where long-term gene therapy might involve brain stem cells, and 3) the first clinical trial with non-invasive monitoring of therapeutic gene expression as a prospective conclusion. This volume will be of value and interest to researchers in this exciting field.Table of ContentsIntroduction; Stem cell-gene therapy: a breakthrough combination magnified by therapeutic stem cell homing; Inherited disease: stem cells and life-long therapeutic gene expression paradigm; Clinical gene therapy trials for ADA deficiency and other Immunodeficiencies; Regenerative cardiovascular medicine: transient gene therapy and autologous stem cell transplantation 1. Transient angiogenic/vasculogenic gene therapy clinical trials Vascular endothelial growth factor (VEGF) gene therapy for critical limb ischemia 2. Autologous stem cell therapy: clinical trials for cardiovascular Disease 3. Synergyzing stem cell* and gene-therapy for cardiovascular Regeneration; Neurodegenerative disease: long-term gene therapy and neural/stem cell targets; Non-invasive monitoring of clinical gene therapy trials

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