Cellular biology (cytology) Books

Book SynopsisThis book presents topical research in the study of leptin, including the interaction of leptin with stress system components; the effects of serum leptin levels of some drugs; leptin as a novel therapeutic reagent in the fight against neurodegenerative diseases; the role of leptin in the activation of the immune system; gender difference in leptin production and leptin senstitivity and neonatal leptin surge.

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Book SynopsisCACO-2 cell cultures are widely used in vitro models in several scientific fields such as nutrition, physiopathology, pharmacology, and toxicology. When cultured onto filters, these cells form a highly polarised epithelium that allows discrimination between apical and basolateral compartments. This book presents topical research in the study of CACO-2 cells and their uses. Topics discussed include the application of CACO-2 cell models as a supportive in vitro tool during drug discovery and formulation; co-culture systems with CACO-2 cells to evaluate the bioactivity of plant extracts and the use of CACO-2 cells in intestinal transport, cell-matrix interactions and wound healing in intestinal villus cells.

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Book SynopsisThis book presents and discusses current research in the study of cell biology. Topics discussed include a new mast-cell adhesion molecule; carbon nanoparticles as substrates for cell adhesion; stress and pancreatic ß cell function; beta cell glucotoxicity; toxin resistant beta-cells; cell division and cell elongation of corynebacterium glutamicum; cell cycle checkpoints and cancer and cyanobacterial cell division.

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Book SynopsisDendritic cells (DCs) are professional antigen presenting cells (APCs) that were discovered several decades ago. They play a crucial role in the innate and adaptive immune response against bacteria or viruses. This book reviews research in the field of dendritic cells including a review of the recent progress in understanding the correlation between the approach used to obtain dendritic cells and their related properties, in order to indicate a correct application of DCs for research or clinical studies.

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Book SynopsisChemotaxis is the phenomenon in which bodily cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food by swimming towards the highest concentration of food molecules, or to flee from poisons. In multicellular organisms, chemotaxis is critical to early and subsequent phases of development, as well as in normal function. This book discusses research in the study of chemotaxis including the cell migration signalosome, the role of chemotaxis in the association of the azospirillum brasilense plant, the role of CD46 in the control of chemotaxis of activated T cells in MS pathogenesis and the regulation of chemotaxis by heterotrimeric G proteins.

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Book SynopsisStem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer''s and Parkinson''s diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for understanding the Physio- and pathology of the body as for development and therapy as well as for understanding the nervous system. This book provides an overview and in depth analysis of recent developments in stem cell research and therapy.

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Book SynopsisOf the estimated trillion cells that build up our bodies, only a little number can self-renew and give rise to many different cell types. These unspecialised cells are called stem cells. Stem cell division and differentiation is fundamental to the development of the mature organism. Stem cells have recently attracted significant attention largely due to their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Because stem cells can become many specialised types of cells of the organs, they have the potential to treat many diseases, including Alzheimer''s disease, Parkinson''s disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis, and rheumatoid arthritis. This book focuses on the application of stem cells in regeneration and repair of the organs in disease and ageing.

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Book SynopsisThis book gives an up-to-date overview of the biomedical aspects of autophagy research, a large interdisciplinary field emerging on intersection of (i) cell, developmental, and cancer biology, (ii) tissue remodelling and plasticity, ageing and longevity; (iii) immunology, microbiology, toxicology, and pathobiology; (iv) regenerative and adaptive biomedicine; and (v) pharmacology.

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Book SynopsisIn this book, the authors present topical research in the study of the causes, types and treatment options for dysplasia. Topics discussed include colonic polyps and hereditary polyposis syndromes; developmental hip dysplasia; the causes and treatment options for bone dysplasia; a discussion on whether elevated intracellular chloride causes epilepsy in cortical dysplasia and dysplasia in ulcerative colitis.

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Book SynopsisThe eosinophil is an enigmatic cell with a continuing ability to fascinate. In this book, experts in the field of eosinophil biology comprehensively update our knowledge on the human eosinophil in health and disease. Topics discussed include a synopsis of eosinophil characteristics, properties and role in disease. Important information on how eosinophils release their potent and toxic granule proteins will be covered and how these basic proteins give rise to pathologies including issues such as the function of the nerves.

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Book SynopsisThis book examines the latest research developments in the study of the production, types and roles in disease of granulocytes. Topics include the regulation of granulocyte differentiation by microRNA and transcription factors; chemotactic assay of human neutrophils and eosinophils; basophilic granulocytes; and the role of granulocytes on the onset of tissue-destructive diseases.

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Book SynopsisWhite blood cells, or leukocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. They live for about 3 to 4 days in the average human body. In this book, the authors present current research in the study of the biology, classification and role in disease of leukocytes. Topics include an analysis of peptides and proteins isolated from alligator leukocytes; modification of immune cell activity by neuroendocrine mediators and development of disease; congenital defects of phagocytes; leukocyte mitochondrial membrane potential in type 1 diabetes; biology of human myeloid dendritic cells; and the leukocyte expression of CD36 as a biomarker for Alzheimer''s disease.

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Book SynopsisProline might be the most studied amino acid in nature. Many authors have reviewed its many functions in cell homoeostasis. Not only it is essential in primary metabolism, but it is also involved in cell defence response to a variety of stresses. This book presents topical research data in the study of pro-line functions, including role of pro-line in plant subject to salinity, pro-line cycle and its role in secondary metabolite accumulation, role of pro-line in catalysing the asymmetric reaction, studies of polyproline peptides, structural characteristics and transition mechanisms of proline-rich peptides, functions of proline in behaviour of neonatal chicks and tumour suppressor activities of proline oxidase.

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Book SynopsisAntimicrobial peptides (AMPs) are small peptides which exhibit broad-spectrum antimicrobial activity and often activity against virus. In addition, AMPs exert several functions including endotoxin neutralization, chemotactic and immunomodulating activities, angiogenesis, and wound repair. In this book, the authors discuss the innate immune system and lipopolysaccharides; the biological role of fish antimicrobial peptides; casein-derived peptides; antimicrobial peptides in intestinal inflammation and infection; insect antimicrobial peptides in immunity and mechanisms of action; potential of AMPs as therapeutic tools against infectious disease; and how LC-MS/MS-based quantitative protein profiling can aid mechanistic studies of antimicrobial peptides.

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Book SynopsisCellular proliferation, as a result of cell growth and cell division, is one of the most fundamental biological processes. Although there is a great deal which remains unclear, significant advances have been made in past decades in our understanding of the process and regulation of cell proliferation. There is considerable evidence that this understanding of different cells and cell proliferation behaviour provides useful information that may be of major importance in disease control, drug discovery, biomaterial development and medical device improvement. This book studies and discusses recent developments in the field of cell proliferation including: the controlling factors for cell proliferation; changes occurring in the cells; therapeutic effects of the biological molecules to the cells; and analysis of cell proliferation based on the quantal concept. Furthermore, the effects that biomaterials and drugs have on cell proliferation are also reviewed in this book.

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Book SynopsisOsteoblasts are highly specialised mesenchymal cells that are mainly responsible for the formation and maintenance of the skeletal architecture. They produce extracellular matrix proteins and are regulators of matrix mineralisation during bone formation and remodelling. In this book, the authors discuss the morphology, functions and clinical implications of osteoblasts. Topics include osteoblasts under mechanical strain; mesenchymal stem cells (MSC) into osteoblasts for bone tissue engineering; osteoblast function and their role in skeletal bone diseases; bone morphogenetic proteins (BMP) and osteoblastogenesis inhibitors; the effect of molecular and biochemical differentiation agents on bone formation; and the evaluation of characteristics of osteoblasts and factors related to osteoblastic differentiation and mineralisation.

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Book SynopsisThis book provides an overview of the scientific methods used to search, analyse, appraise and synthesise studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoural and non-tumoural disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called "translational medicine". Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease.

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Book SynopsisThe human skin is constantly exposed to a large number of external pathogens, due to daily contact with the environment. The observation that extensive skin infections are relatively rare suggests the presence of an efficient host defence system at the skin surface. Recent findings indicate the importance of keratinocytes as effectors of innate immunity, but also as regulators of acquired immune responses, inflammation and wound repair. This book considers the current findings regarding the role of keratinocytes in the epidermis with special interest to mechanisms involved in host defence. Finally, the clinical relevance of the functions of keratinocytes in the innate immunity is also discussed.

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Book SynopsisIn this book, the authors present current research in the study of the molecular structure, physiochemical properties and interactions with the environment of cell membranes. Topics discussed in this compilation include the generation and characterisation of recombinant HM-1 single-chain anti-idiotypic antibodies and their applications; large conductance of calcium activated potassium channels from protein complexes to function in mitochondrial associated ER membranes; unexpected plasma membrane location for a disulphide isomerase protein; and the effects of surface charge and particle size of cell-penetrating peptide/nanoparticle complexes on cellular internalisation.

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Book SynopsisPast, present, and future research of hepatic stellate cells (HSCs; also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, Ito cells) are summarised and discussed in this review. Kupffer discovered black-stained cells in the liver by the gold chloride method and named the cells the stellate cells (Sternzellen in German) in 1876. Wake re-discovered the cells in 1971 using the same gold chloride method and various modern histological techniques including electron microscopy. Between the discovery and re-discovery, the HSCs disappeared from the history of research. Identification, establishment of cell isolation and culture methods, and the development of cellular and molecular biological techniques have promoted HSC research after the re-discovery of the cell. The research is entering a new era, namely, the golden age after the dark ages. In the future, the research of HSCs will develop more into not only the clinical field but also into the basic research fields. In this book, we describe the past, present, and future of HSC research.

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Book SynopsisB cells belong to a group of white blood cells known as lymphocytes, making them a vital part of the immune system. The human body makes millions of different types of B cells each day that circulate in the blood and lymphatic system performing the role of immune surveillance. They do not produce antibodies until they become fully activated. In this book, the authors present current research in the study of the molecular biology, developmental origin and impact on the immune system of B cells. Topics discussed include the role of B cells in intracellular bacterial pathogen infections; dynamic clustering of BCR-lipid rafts in antigen affinity discrimination by B cells; and B cells as a key player in the pathogenesis of multiple sclerosis.

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Book SynopsisIn this book, the authors present current research in the study of the biology, characterisation and potential clinical application of progenitor cells. Topics discussed include endothelial progenitor cells and cardiovascular disease; isolation, expansion and clinical therapy of human corneal epithelial stem/progenitor cells; genetically engineered blood pharming; regulation of neural progenitor cells by Wnt5a-signaling in the developmental central nervous system; endothelial progenitor cells in a clinical setting; role of microRNAs in endothelial progenitor cells and their implication for cardiac repair; and cellular origins in amphibian regeneration.

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Book SynopsisAxons are nerve fibres that typically conduct electrical impulses away from the neuron''s cell body. The function of the axon is to transmit information to different neurons, muscles and glands. In this book, the authors discuss the cell biology, molecular dynamics and role in neural repair and rehabilitation of axons. Topics include the traumatic retraction of living neural processes and their inhibitions; water translocation from the axoplasm into the glioplasm during reactive reorganisation of myelinated nerve fibres; problems and mechanisms in axonal afterdischarges; the putative role of axon cytoskeleton protein in MS repair; microtubules as a potential therapeutic target for the treatment of neurodegenerative diseases; morphometrical and molecular biological analyses of facial nerves in healthy adults and patients with facial nerve palsy; intrinsic axon growth potential; and sensory axonal guidance by chemorepulsive and chemoattractive cues in higher vertebrates.

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Book SynopsisFor many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- ''lipid raft'' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signalling processes? Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration?

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Book SynopsisThe ability to observe the world around us through sight provides us with many advantages we may take for granted daily. We are able to recognise a hazard well in advance because we see it; we can find allies because we see them. Further, thanks to the perception of the world that gives us sight, we can collect information to help us develop feelings, such as trust in others, love and sensations, like beauty. However, the mechanism to enjoy this capability is really complex, starting with the structure responsible for receiving, processing and transmitting information to the brain. This book discusses the ways in which ganglion cells are used in the nervous system, as well as its morphology, functional development and role in diseases.

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Book SynopsisActive oxygen species are produced as inescapable by-products of a normal aerobic metabolism, and their production is further enhanced by exposure to certain environmental conditions, or as a result of some diseases. Oxidative stress is defined as an imbalance between the production of free radicals (FR) and antioxidant defences in favour of the former, which can result from an excess of prooxidant, antioxidant deficiency or both factors. There are many kinds of FR, but these can be grouped together under the name of reactive oxygen species (ROS) or reactive nitrogen species (RNS), determined by the ability of each species according to the four basic characteristics: reactivity, specificity, selectivity and diffusivity. This book aims to discuss the biological effects, role in diseases, and causes of oxidative stress. Some of the topics provided include oxidative stress in biofilms; age realtion to oxidative stress; controlling of oxidative stress in non-alcoholic steatohepatitis; and the role of nitric oxide toxicity and oxidative stress in graft versus host disease.

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Book SynopsisIn this book, the current advances on the functional role of molecular chaperones in protozoan''s mechanisms of response to stressful conditions, as well as an overview of studies focusing on molecular chaperones as potential targets for designing novel anti-parasitic drugs, are examined. In the second chapter, the current progress regarding the structure-function relationship as well as its association with the chaperone-like activity of the mammalian PDIA1/P4HB protein are discussed. The final chapter focuses on the cytoplasmic and nuclear functions of URI/Bud27 in different organisms.

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Book SynopsisThis book is devoted to the study of physiological properties of a living axoplasm, which, as it turns out, is hardly studied as a single organ. This study revealed a number of new physiological properties. The mechanism of simultaneous currents bidirectional axoplasm, disappearance streams and reappearance of the apical dendrites of pyramidal neurons in the brain during stress were revealed, as well as the causes of the similarity of nerve terminals regardless of their very different physiological functions. There exists proof of differences in presynaptic terminals of the postsynaptic. The reasons for the impossibility of treating transected axons using surgical sutures are discussed, and finally the cause of the absence of swelling properties in myelinated fibers with hypotension environment is solved. Some new approaches to the treatment of fibers and early manifestations of diastase nonspecific reactions are explored as well.

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Book SynopsisElegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things.  Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine.  Lewis Thomas writes, Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us.

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Book SynopsisDeath, for bacteria, is not inevitable. Protect a bacterium from predators, and provide it with adequate food and space to grow, and it would continue living--and reproducing asexually--forever. But a paramecium (a slightly more advanced single-cell organism), under the same ideal conditions, would stop dividing after about 200 generations--and die. Death, for paramecia and their offspring, is inevitable. Unless they have sex. If at any point during that 200 or so generations, two of the progeny of our paramecium have sex, their clock will be reset to zero. They and their progeny are granted another 200 generations. Those who fail to have sex eventually die. Immortality for bacteria is automatic; for all other living beings--including humans--immortality depends on having sex. But why is this so? Why must death be inevitable? And what is the connection between death and sexual reproduction? In Sex and the Origins of Death, William R. Clark looks at life and death at the level of the cell, as he addresses such profound questions as why we age, why death exists, and why death and sex go hand in hand. Clark reveals that there are in fact two kinds of cell death--accidental death, caused by extreme cold or heat, starvation, or physical destruction, and programmed cell death, initiated by codes embedded in our DNA. (Bacteria have no such codes.) We learn that every cell in our body has a self-destruct program embedded into it and that cell suicide is in fact a fairly commonplace event. We also discover that virtually every aspect of a cell''s life is regulated by its DNA, including its own death, that the span of life is genetically determined (identical twins on average die 36 months apart, randomly selected siblings 106 months apart), that human tissue in culture will divide some 50 times and then die (an important exception being tumor cells, which divide indefinitely). But why do our cells have such programs? Why must we die? To shed light on this question, Clark reaches far back in evolutionary history, to the moment when inevitable death (death from ageing) first appeared. For cells during the first billion years, death, when it occurred, was accidental; there was nothing programmed into them that said they must die. But fierce competition gradually led to multicellular animals--size being an advantage against predators--and with this change came cell specialization and, most important, germ cells in which reproductive DNA was segregated. When sexual reproduction evolved, it became the dominant form of reproduction on the planet, in part because mixing DNA from two individuals corrects errors that have crept into the code. But this improved DNA made DNA in the other (somatic) cells not only superfluous, but dangerous, because somatic DNA might harbour mutations. Nature''s solution to this danger, Clark concludes, was programmed death--the somatic cells must die. Unfortunately, we are the somatic cells. Death is necessary to exploit to the fullest the advantages of sexual reproduction. In Sex and the Origins of Death, William Clark ranges far and wide over fascinating terrain. Whether describing a 62-year-old man having a major heart attack (and how his myocardial cells rupture and die), or discussing curious life-forms that defy any definition of life (including bacterial spores, which can regenerate after decades of inactivity, and viruses, which are nothing more than DNA or RNA wrapped in protein), this brilliant, profound volume illuminates the miraculous workings of life at its most elemental level and finds in these tiny spaces the answers to some of our largest questions.Trade ReviewAnyone who reckons that science writing is dry stuff may find their outlook broadened by this little book about the biology of death. * New Scientist *

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Book SynopsisIn Life Itself, Boyce Rensberger, science writer for The Washington Post, takes readers to the frontlines of cell research with some of the brightest investigators in molecular, cellular, and developmental biology. Virtually all the hottest topics in biomedical research are covered here, such as how do cells and their minute components move How do the body''s cells heal wounds? What is cancer? Why do cells die? And what is the nature of life? The solutions to the most pressing challenges facing scientists today -- from the efforts to conquer disease to the quest to understand life itself -- will be found in the innermost workings of the cell.In Life Itself, Rensberger paints a colourful and fascinating portrait of modern research in this vital area, an account which will enthrall anyone interested in state-of-the-art science or the incredible workings of the human body.Trade ReviewLife Itself is a wonderfully readable digest of everything currently known about the mechanisms by which living cells perform their myriad tasks. * The New York Times Book Review *An elegant, authoritative, yet felicitously written book that will appeal to anyone who is interested in how cells work....a compelling portrait of terrestrial life in its many guises. * New Scientist *Table of Contents1. A Particle of Life ; 2. Molecular Motors ; 3. Animation ; 4. The Living-Room Cell ; 5. How Genes Work ; 6. One Life Becomes Two ; 7. Two lives Become One ; 8. Constructing a Person ; 9. Pumping Protein ; 10. Heal Thyself ; 11. In Self-Defense ; 12. Revolution ; 13. The Immortality Within

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Book SynopsisWhat is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world''s most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms - in particular, the supremely well-researched bacterium E. coli - because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist''s personal attempt to wring understanding from the tide of knowledge.Trade Review"The work is like a breath of fresh air in a scientific world otherwise obsessed with excessive reductionism."--BioEssays"Witty and erudite, this scientific book hails as a literary achievement. Comprehensive and up to date, Franklin Harold traces the roots--historical, thermodynamic, and biochemical--of today's biological revolution."--Lynn Margulis, co-author (with Dorion Sagan) of both What is Life? and What is Sex?"This book helps us understand why the search for answers to the riddle 'What is life?' is a noble quest."--Howard C. Berg, author of Random Walks in Biology

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Book SynopsisNeural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information processing in single neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive anTable of Contents1. The membrane equation ; 2. Linear cable theory ; 3. Passive dendritic trees ; 4. Synaptic input ; 5. Synaptic interactions in a passive dendritic tree ; 6. The Hodgkin-Huxley model of action-potential generation ; 7. Phase space analysis of neuronal excitability ; 8. Ionic channels ; 9. Beyond Hodgkin and Huxley: calcium, and calcium-dependent potassium currents ; 10. Linearizing voltage-dependent currents ; 11. Diffusion, buffering, and binding ; 12. Dendritic spines ; 13. Synaptic plasticity ; 14. Simplified models of individual neurons ; 15. Stochastic models of single cells ; 16. Bursting cells ; 17. Input resistance, time constants, and spike initiation ; 18. Synaptic input to a passive tree ; 19. Voltage-dependent events in the dendritic tree ; 20. Unconventional coupling ; 21. Computing with neurons - a summary

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Book SynopsisCryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approachTable of Contents1: Introduction 2: Electron Microscopy of Macromolecular Assemblies 3: Two-Dimensional Averaging Techniques 4: Multivariate Data Analysis and Classification of Images 5: Three-Dimensional Reconstruction 6: Interpretation of Three-Dimensional Images of Macromolecules Appendix 1: Some Important Definitions and Theorems Appendix 2: Profiles, Point-Spread Functions, and Effects of Commonly Used Low-Pass Filters Appendix 2: Bibliography of Methods Appendix 2: Bibliography of Structures Appendix 2: Special Journal Issues on Image Processing Techniques

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Book SynopsisThe Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.Trade ReviewThe text is impressively modern, with up-to date information on the trendiest areas of neurobiology . . .the book is highly visual, with figures on virtually every page. The figures deserve special comment because they are a teacher's dream: simple and uncluttered, but conceptually powerful. Frankly, although the recommendation is often absurd, The Neuron is one of those books that really does belong on every shelf. * Nature *The format of each chapter is ideally suited for easy, enjoyable, and almost effortless learning . . . This is a superbly written and well-illustrated text covering all of the major aspects of neuroscientific knowledge . . . every neuroscientist should keep a copy handy. * Journal of Psychiatry and Neuroscience *This is a first-rate textbook for a course in cellular neurobiology for upper-level university students. My colleagues and I took it out on a shakedown cruise with a class of 250 undergraduates. The wind really caught their sails, and we sped quickly through it in the ten weeks of the academic quarter. The students appreciated the consistent clarity and the uniformity of style. The illustrations are highly conceptual and were easily understood . . . The up-to-date presentation of many exciting recent findings is a great strength. General principles are illustrated with a useful blend of data from vertebrate and invertebrate systems. * William S Messer, Jr., in The Quarterly Review of Biology *An outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. * Canadian Journal of Neurological Sciences *Table of ContentsPreface to the Fourth Edition ; I. Introduction ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. Electrical Properties of Neurons ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels Are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. Intercellular Communication ; 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Sensory Receptors ; IV. Behavior and Plasticity ; 14. The Birth and Death of a Neuron ; 15. Neuronal Growth and Trophic Factors ; 16. Adhesion Molecules and Axon Pathfinding ; 17. Formation, Maintenance, and Plasticity of Chemical Synapses ; 18. Intrinsic Neuronal Properties, Neural Networks and Behavior ; 19. Learning and Memory

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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