Biotechnology Books

Book SynopsisThe edited book highlights various emerging Omics tools and techniques that are currently being used in the analysis of responses to different abiotic stress in agronomically important cereals and their applications in enhancing tolerance mechanism. Plants are severely challenged by diverse abiotic stress factors such as low water availability (drought), excess water (flooding/ waterlogging), extremes of temperatures (cold, chilling, frost, and heat), salinity, mineral deficiency, and heavy metal toxicity. Agronomically important cereal crops like Rice, Wheat, Maize, Sorghum, Pearl Millet, Barley, Oats, Rye, Foxtail Millets etc. that are the major sources of food material and nutritional components for human health are mostly exposed to abiotic stresses during the critical phases of flowering and grain yield. Different Omics platforms like genomics, transcriptomics proteomics, metabolomics and phenomics, in conjunction with breeding and transgenic technology, and high throughput technologies like next generation sequencing, epigenomics, genome editing and CRISPR-Cas technology have emerged altogether in understanding abiotic stress response and strengthening defense and tolerance mechanism of different cereals. This book is beneficial to different universities and research institutes working with different cereal crops in the areas of stress physiology, stress-associated genes and proteins, genomics, proteomics, genetic engineering, and other fields of molecular plant physiology. The book can also be used as advanced textbook for the course work of research and master’s level students. It will be of use to people involved in ecological studies and sustainable agriculture. The proposed book bring together the global leaders working on environmental stress in different cereal crops and motivate scientists to explore new horizons in the relevant areas of research.Table of ContentsChapter 1. Morphological, architectural and biochemical modifications of cereal crops during abiotic stress.- Chapter 2. Cereal physiology, flowering and grain yield under salinity and drought stress.- Chapter 3. Physiology, flowering and grain yield under abiotic stress imposed by heavy metals.- Chapter 4. Priming effect in developing abiotic stress tolerance in cereals through metabolome reprograming.- Chapter 5. Understanding abiotic stress tolerance in cereals through genomics and proteomics approaches.- Chapter 6. Metabolome analyses in response to diverse abiotic stress.- Chapter 7. Metabolomic profiling of different cereals during biotic and abiotic stresses.- Chapter 8. Plant breeding strategies for abiotic stress tolerance in cereals.- Chapter 9. Transgenic strategies to develop abiotic stress tolerance in cereals.- Chapter 10. Genetically engineered cereals tolerant to abiotic stress.- Chapter 11. Genome editing and CRISPR-Cas technology for enhancing abiotic stress tolerance in cereals.- Chapter 12. Abiotic stress tolerance in cereals through genome editing.- Chapter 13. Varietal physiology, metabolic regulation and molecular responses of rice genotypes to diverse environmental stresses.- Chapter 14. Breeding and Omics Approaches to Understand Abiotic Stress Response in Rice.- Chapter 15. Genomics and transcriptomics approaches to understand abiotic stress response in rice.- Chapter 16. Biochemical and molecular mechanism of wheat to diverse environmental stresses.- Chapter 17. How microRNAs Regulate Abiotic Stress Tolerance in Wheat? A Snapshot.- Chapter 18. Molecular-genetic studies, breeding and genomics-based approaches to develop abiotic stress tolerance in sorghum.- Chapter 19. MicroRNAs shape the Tolerance Mechanisms against Abiotic Stress in Maize.- Chapter 20. Transcriptome, proteome and metabolome profiling for abiotic stress tolerance in maize and barley.- Chapter 21. Omics tools to understand abiotic stress response and adaptation in rye, oat and barley.- Chapter 22. Genomic tools and proteomic determinants for abiotic stress tolerance in pearl millet (Pennisetum glaucum) and foxtail millet (Setaria italica L.).- Chapter 23. Advancement in Omics Technologies for Enhancing Abiotic Stress Tolerance in Finger millet.- Chapter 24. Buckwheat (Fagopyrum esculentum) response and tolerance to abiotic stress.- Chapter 25. Abiotic Stress Response and Adoption of Triticale.

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Book SynopsisThis book dispenses a comprehensive coverage of up-to-date account of genomics and genome editing enriched smart plant breeding approaches for enhancing genetic gains in vegetable crops in the post-genomics era. The main focus of the present volume is to illuminate the applications of new techniques evolved in the post-genomics era. The techniques covered are high-throughput sequencing of DNA and RNA, genome editing, epigenetics and epigenomics, genotype by sequencing (GBS), QTL-seq and RNA-seq for transcriptome analysis. Vegetables are the important component of healthy diet, source of energy and hold a promising position in building up a strong immunity. Zero hunger and attaining the food and nutritional security is the top priority of United Nations development goals. Smart breeding of food and vegetable crops to fight the challenges ahead in sustainable manner by keeping the harmony with nature is an important approach to fulfill the United Nations Sustainable Development Goals (UN-SDGs). This edited book highlights the modern results in smart vegetable breeding in the post genomics era and forecasts crucial areas of future needs. It is an important reference for the, readers, students, researchers, scientists in academia and research industries to provide them comprehensive information of innovative approaches for crop improvement in the post-genomics era and in the era of and climate change. Even the readers, academia, social activists, and others fond of reading will get a fair idea of journey travelled so far and future roadmap for fighting the challenges ahead to meet the sustainable development goals.Table of ContentsAttached

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Book SynopsisThis book covers different aspects of biodegradable packaging, such as their sourcing and application in food industries. The book focuses on the production and characterization of biodegradable food packaging derived from plant, animal and microbial sources. Chapters highlight the nano-technological interventions in biodegradable food packaging and the less studied microbial biopolymer-based biodegradable food packaging makes it distinct from other related books. It includes the latest research and development in the areas of food processing, food packaging, material science and polymeric science. It also discusses the standards and regulatory guidelines about the biodegradability testing of these polymers.This book is meant for researchers in food science, food packaging, bioprocess technology, polymer science and biochemical engineering. It is also beneficial for faculty members and students of food microbiology, food technology, dairy technology. The book is also meant for small entrepreneurs and farmers who are interested in bio-plastic usage for food packaging.Table of Contents 1. Introduction-Scope and importance of biodegradable polymers 2. Plant derrived biopolymers in food packaging-current status and market potential 3. Animal derived biopolymers in food packaging-current status and market potential 4. Microbially derived biodegradable polymers as food packaging tool 5. Polyhdroxyalkanoates (PHAs) in Food packaging 6. Polylactide (PLA) in biodegradable food packaging- synthesis, properties & biocompatibility 7. Role of agro-waste in economical food packaging synthesis 8. Enzymes involved in synthesis of biodegradable food packaging materials 9. Metabolic engineering for the synthesis of biodegradable polymers with potential applications in food packaging 10. Downstream processing strategies for synthesis of biodegradable polymers 11. Functionality test methods for biodegradable polymers 12. Nanocomposite biodegradable polymers for food packaging 13. Application of biopolymer blends as edible films and coatings in food packaging 14. Biopolymer based active and intelligent packaging for food applications. 15. Standards and guidlines for testing biodegradability of bio-plastic 16. Future prospects of Biodegradable polymers in Food industry

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Book SynopsisThis edited book provides the readers with the concepts and in-depth knowledge of plant disease assessment and conventional and modern technologies that aid in precise and accurate phytomathometery. This book discusses the evolution of plant disease assessment procedures from the primary visual estimation-based assessment to modern approaches, their practical application for reliable disease quantification, yield loss estimation, and the efficacy of disease control strategies for sustainable crop protection. Significant information is provided on the major aspects of the topic, including remote sensing, imaging techniques, molecular phytopathometery, microarray, and immunotechnology. The book helps plant scientists, plant pathologists, practitioners, researchers, and students in disease quantification, developing predictive models for plant disease epidemics, assessing crop losses, and the magnitude of plant disease control methods. This book describes the classical plant disease assessment methods based on visual observations. It Provides information regarding the modern and emerging technologies in Phytopathometery, precision, and accuracy. This book also discusses the application of disease assessments in predictive models, disease warning systems, expert systems, and decision support systems in applied plant pathology.Table of Contents1. Phytopathometry: A trans-disciplinary concept.- 2. Visual Estimation: a classical approach for plant disease estimation.- 3. Remote Sensing: A new tool for disease assessment in crops.- 4. Image analysis and processing approach: an automated plant disease recognition technology.- 5. Hyper-spectral imaging through Spatial and Spectral Sensors for Phytopathometry.- 6. Fluorescent imaging system-based plant phenotyping for disease recognition.- 7. Concept and Application of Infrared Thermography for Plant Disease Measurement.- 8. Application of Biosensors in Plant Disease Detection.- 9. Immunotechnology for Plant Disease Detection.- 10. Molecular Phytopathometry.- 11. Microarray technology for detection of plant diseases.- 12. Predictive Models for Plant Disease Assessment.- 13. Extension Plant Pathology.

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Book SynopsisThis book offers an overview of the current knowledge on beta glucanase enzymes derived from actinobacterial source, their structure, functions and industrial applications. It summarizes the exploitation of actinomycetes, assay methods for beta glucanase screening, structural characterisation, genetic engineering, protein engineering, strategies for purification, characterisation and finally how to synthesize a hybrid enzyme of beta glucanases.Enzyme beta glucanases have considerable interest in industrial biotechnology owing to its distinct effect on the hydrolysis of insoluble beta glucan molecules and applications in particular industrial sectors such as food, feed and beverages industries. The beta glucanases are characterized extensively in microorganisms viz. bacteria, fungi and also in plants. A wide varieties of actinobacterial β- glucanases have exclusively active on β-glucan substrates and cleave the mixed linkage β-glucan chains at different points. This is significant for picking precise substrates for the assay of each type of enzymes within this enzyme groups. The well recognized specificity and mechanism of action within the enormous substrates allow to understand that most of them are varied from cellulases, excluding β-1,4-glucanases. The progress in genetic and protein engineering in actinobacterial beta glucanases improves the stability, activity and thermodynamic properties in relation with industrial relevance. This book will be useful for researchers and students engaged in industrial biotechnology, enzyme production, molecular biology, protein engineering and many more.Table of Contents1.An Introduction to Beta Glucan and Beta Glucanases.- 2.Industrial Applications of Beta Glucanases.- 3.Microbial Sources of Beta Glucanase Enzymes.- 4.Role of Beta Glucanases in Animal Nutrition.- 5.Betaglucanse in Breweries.- 6. Exploitation of Actinobacteria for Beta Glucanolytic enzymes –Screening and Characterisation.- 7.Structural Characterisation of Beta Glucanase Genes from Actinobacteria.- 8.Application of Codon Optimization in Actinobacterial Beta Glucanases.- 9.Actinobacterial Beta Glucanases: Recombinant Expression of in E. coli.- 10.Purification and Properties of Recombinant Beta Glucanases Enzymes.- 11.Fungal Beta Glucanases.- 12.Industrial Production and Characterisation of Beta Glucanases.- 13.Protein Engineering of Beta Glucanase Enzymes.- 14.Biotechnological Avenues in Hybrid Beta Glucanase Enzyme Production.

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Book SynopsisThis book elucidates the sustainable production of commercially important biomolecules in medicines, food, and beverage processing, through biological systems, including microorganisms, animal cells, plant cells, tissues, enzymes, and in vitro. It discusses promising technologies for the manipulation of cells including, genetic engineering, synthetic biology, genome editing, and metabolic engineering. The initial chapters of the book introduce topics on biomanufacturing, circular economy, strain design and improvement, upstream and downstream processing. The subsequent chapters cover artificial intelligence-assisted production, designer cell factories, biosensors for monitoring biomolecules, different cells factories, biosynthetic pathways, and genome editing approaches for scale-up biomanufacturing. Lastly, the book discusses the opportunities and challenges of implementing biological systems for the production of biomolecules. ​This book is a valuable source for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand biomanufacturing for the sustainable production of biomolecules.Table of ContentsChapter 1. Strain design and optimization methods for sustainable production.- Chapter 2. Designer and minimal cells for production of biomolecules.- Chapter 3. Recent advances in downstream processing deployed in the treatment of pharmaceutical effluents.- Chapter 4. Microbial conversion of waste to biomolecules.- Chapter 5. Biosensor for detecting biomolecules.- Chapter 6. Artificial Intelligence Assisted Production of Biomolecules.- Chapter 7. Escherichia coli cell factory for synthesis of biomolecules.- Chapter 8. Bacillus subtilis cell factory.- Chapter 9. Pseudomonas putida cell factory.- Chapter 10. Cyanobacteria for marine based biomolecules.- Chapter 11. Yeast cell factory for biomolecules.- Chapter 12. Plant cell factory for biomolecules.- Chapter 13. Genetic manipulation of crop for enhanced food quality and nutrition towards sustainable production.- Chapter 14. Insect cell factory for production of biomolecules.- Chapter 15. Mammalian cell factor for biomolecules.- Chapter 16. Genome editing guided production of biomolecules.- Chapter 17. Cell free protein synthesis system for sustainable production of biofuels.- Chapter 18. Challenges and opportunities in biomanufacturing.

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Book SynopsisThis book addresses waste generation problems from various sectors, including industries, agriculture, and household. It focuses on how modern biotechnological approaches could help manage waste in an eco-friendly manner and generate precious bioenergy. It discusses the inadequate waste management systems damaging the environment and its adverse impacts on climate change-related problems. This book covers all the essential information regarding various types of waste and their management. It is a comprehensive compilation for understanding the efficient generation of bioenergy. It is a relevant reading material (resource) for anyone who wishes to study waste management as Chemist, Biologist, Biotechnologist, Industrialist, Ecologist, Microbiologist, Economist, and all disciplines related to the environment. Table of ContentsPart 1 Introductory Chapters.- 1 Emerging Frontiers of Microbes as Agro-waste Recycler.- 2 Microbes: the next generation bioenergy producers.- 3 Emerging and eco-friendly approaches for waste management.- 4 Ecofriendly microbial biofuel production from waste.- 5 Bioremediation: Current research trends and applications.- 6 Bioremediation: an approach for environmental pollutants detoxification.- 7 Bioethanol extraction and its production from agricultural residues for sustainable development.- Part 2 Biotechnological approaches.- 8 Byproduct valorization of vegetable oil industry through biotechnological approach.- 9 Omics tools: Approaches for microbiomes analysis to enhance bioenergy production.- 10 Omics (genomics, proteomics, metabolomics etc.) tools to study the environmental microbiome and Bioremediation.- Part 3 Industrial waste management.- 11 Microalgae: Omics approaches for biofuel production and biomedical research.- 12 Waste Utilization and Minimization in Food Industry.-13 Ligninolytic microbes and their role in effluent management of pulp and paper industry.- 14 Production of Polyhydroxyalkanoates using waste as raw materials. 15 Newer Aspects of Waste-to-Valorisation Technologies in Food Industry.- 16 Xylanase in waste management and its industrial applications.- 17 Organic Acid Production from Agricultural Waste.

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Book SynopsisThis book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.Table of ContentsChapter 1. Immunopathology of respiratory diseases.- Chapter 2. Introduction to Chronic Respiratory Diseases: A Pressing Need for Novel Therapeutic Approaches.- Chapter 3. Role of Indian Herbal Medicine in the treatment of Pulmonary Diseases.- Chapter 4. Asthma-induced inflammatory responses and reversal by botanicals.- Chapter 5. Medicinal plants in targeting asthma.- Chapter 6. Incipient need of medicinal plants in targeting chronic obstructive pulmonary disease.- Chapter 7. Utilization of Natural Compounds for Treatment of Tuberculosis-I.- Chapter 8. Medicinal plants in the treatment of Tuberculosis-II.- Chapter 9. Medicinal Plants in the Treatment of tuberculosis-III.- Chapter 10.Natural compounds as versatile potential therapeutic agents of lung cancer.- Chapter 11. Exploring the potential of medicinal plants in Lung Cancer.- Chapter 12. Effect of Medicinal Plants against Lung Cancer.- Chapter 13. Medicinal Plants used in the treatment of pulmonary hypertension- I.- Chapter 14. Medicinal Plants used in the treatment of pulmonary hypertension-II.- Chapter 15. Herbal bioactives for the treatment of idiopathic pulmonary fibrosis.- Chapter 16. Medicinal Plants targeting Bronchitis.- Chapter 17. Role of medicinal plants in the treatment of pulmonary edema.- Chapter 18. Medicinal Plants Used in the Treatment of Influenza a Virus Infections.- Chapter 19. Medicinal Plants used in the treatment of influenza A virus infections.- Chapter 20. COVID-19 pandemic panic: prophylactic as well as therapeutic management with traditional ethnic phytopharmaceuticals with challenging nano-spray inhaler and advanced drug delivery system.- Chapter 21. Targeting SARS-CoV2 novel corona (COVID-19) virus infection using medicinal plants.- Chapter 22. Promising plant based bioactive natural products in combating SARS-CoV2 novel corona (COVID-19) virus infection.- Chapter 23. Medicinal plant based advanced drug delivery system for the treatment of chronic lung diseases.- Chapter 24. Medicinal Plant Based Advanced Drug Delivery System for the Treatment of Chronic Lung Diseases.- Chapter 25. Application of nanodrugs derived from active metabolites of medicinal plants for the treatment of inflammatory and lung diseases: Recent advances.

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Book SynopsisBiological molecular motors provide most cells with the dynamic systems required for their day-to-day existence. Examples occur in even the simplest organism (e.g. a bacteria virus), and the range of tasks that they carry out is vast. Over the last few years, there has been a large increase in the study of these motors, and it is becoming apparent that many motors will find uses in either bionanotechnology or synthetic biology.Molecular Motors in Bionanotechnology describes a wide range of molecular motors, ranging from chemical motors to biological motors, in a manner that updates, or reviews, both classification of the type of motor and the grouping into families. Many techniques have evolved to study and characterise molecular motors at the single-molecule level (e.g. use of molecular tweezer devices for single-molecule studies). The text introduces the reader to the concepts and benefits of these techniques. In addition, it looks at the structural information and how this helps understand function and, finally, how some of these motors are being used or may be used in the future as part of a synthetic biology approach to building devices and sensors.

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Book SynopsisThis book presents an overview of the current state of research in both synchrotron radiation and structural proteomics from different laboratories worldwide. The book presents recent research results in the most advanced methods of synchrotron radiation analysis, protein micro- and nano crystallography, X-ray scattering and X-ray optics, coherent X-Ray diffraction, and laser cutting and contactless sample manipulation are described in details. The book focuses on biological applications and highlights important aspects such as radiation damage and molecular modeling.Trade Review"This book provides valuable insight into the growing field of structural proteomics."—Prof. Gary Stein, University of Massachusetts Medical School, USATable of ContentsProtein Micro- and Nanocrystallography Using Synchrotron Radiation. Single-Bounce Monocapillary X-Ray Optics: Design and Biological Applications. Thermophilic Enzymes of Potential Industrial Use: Structure and Function. Model Lysozyme Crystal Versus Aggregate, Un Confined Formation as Viewed by Recent Theory Aided by Computer Experiment. Molecular Modeling to Facilitate Protein Crystallization. Structural Analysis of the β-Subunit of the Translation Initiation Factor Aif2 from Different Species: Role of Zn Ions. Towards the Understanding of Molecular Aspects of Helicobacter pylori cag-PAI. Using X-Ray Scattering to Study the Structures of Membrane-Associated Proteins. An Overview of Langmuir Blodgett Protein Crystals via GISAXS, LASER , Raman and AFM. Radiation Damage in Protein Structural Characterization by Synchrotron Radiation: State of the Art and Nanotechnology-Based Perspective. Contactless Sample Manipulation for Synchrotron Radiation Experiments. Gold on Glass—The Annealing Process Investigated with GISAXS and Ellipsometry. Three-Dimensional Visualization of a Human Chromosome Using Coherent X-Ray Diffraction.

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Book SynopsisThis book introduces various fields of metal biotechnology, emphasizing applications for the fields of environment conservation and resource recycling. The topics discussed include wastewater treatment and bioremediation technologies for hazardous metals making use of metal metabolism by microorganisms and other organisms; recovery and recycling of metals from drainage and waste sources; the biological synthesis and processing of new metallic materials and monitoring of metals for industrial uses; and bio-informatics in metal biotechnology. These topics are expected to be of great help for new developments in these new technologies.Trade Review"This book represents a broad sampling of the great diversity of biochemical interactions possible between living biota (microorganisms and plants) with metals and metalloids. A majority of the topics covered are devoted to sequestration mechanisms for toxic metals, but there are also a number of unusual topics addressed, including practical means of capture of precious metals and the use of microorganisms in the formation of nano-size materials with potential industrial applications. The book serves as not only an excellent departure point for students and scientists entering into this realm of research but also a handy reference for those already engaged in the area, as well as a rich primary reference source for educators seeking to expand their course curriculum lectures."—Dr. Ronald S. Oremland - U.S. Geological Survey, USATable of ContentsMicrobial Manganese(II) Oxidation: A Potential Tool for Treatment of Metal-Contaminated Waters. Biological Treatment for Removal of Iron, Manganese, and Arsenic from Groundwater. Removal of Selenium from Wastewater Using a Selenium-Reducing Bacterium. Microbial Reduction and Mobilization of Arsenic for Bioremediation of Contaminated Soil. Phytoremediation of Boron-Polluted Soil and Water. Phytoremediation of Cadmium-Contaminated Soil: Acceleration of Phytoremediation by Combination Use of Chelating Agents. Phytoremediation for Soils Contaminated with Heavy Metals Using the Symbiosis Between Astragalus sinicus with Rhizobia. Construction of Yeast Bioadsorbent by Cell Surface Engineering. Bioleaching of Metals from Solid Waste Incineration Ash. Dissolution of Precious Metals from Waste Printed Circuit Boards by Using Bacteria. Biosorption of Uranium and/or Thorium Using Microorganism. Characteristics of Biogenous Iron Oxide Microtubes Formed by Iron-Oxidizing Bacteria, Leptothrix ochracea. Microbial Formation of Semiconductor Nano-Particles Contained Selenium or Tellurium and Metals. Biomachining–Micromachining of Metals by Bacteria. Biosensors for Toxic Heavy Metals. Cell Surface Design for Selective Recovery of Rare Metal Ions. Bioinformatics Tools for the Next Generation of Metal Biotechnology.

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Book SynopsisThe design and synthesis of molecularly or supramolecularly defined interfacial architectures have seen in recent years a remarkable growth of interest and scientific research activities for various reasons. On the one hand, it is generally believed that the construction of an interactive interface between the living world of cells, tissue, or whole organisms and the (inorganic or organic) materials world of technical devices such as implants or medical parts requires proper construction and structural (and functional) control of this organism–machine interface. It is still the very beginning of generating a better understanding of what is needed to make an organism tolerate implants, to guarantee bidirectional communication between microelectronic devices and living tissue, or to simply construct interactive biocompatibility of surfaces in general.This exhaustive book lucidly describes the design, synthesis, assembly and characterization, and bio-(medical) applications of interfacial layers on solid substrates with molecularly or supramolecularly controlled architectures. Experts in the field share their contributions that have been developed in recent years.Table of ContentsSelf-Assembled Monolayers (SAMs). Multi-Valent Chelator SAMs. Gemini SAMs. PEG SAMs. Electrochemically Designed SAMs. Polymer Brushes. Ultra-Sensitive Biosensing with Polymer Brushes. Noncovalent Anchoring of Proteins to Surfaces. S-Layer Proteins. Heparan Sulfate Surfaces to Probe the Functions of the Master Regulator of the Extracellular Space. Hemocompatible Surfaces. Peptide Nanotube Coatings for Bioapplications. Proteoglycanylated Surfaces. Surface-Attached Polymeric Hydrogel Films. Evanescent Wave Biosensors with Hydrogels Binding Matrix. IPNs. Biofunctional Grafted Dendrons. Glucase Biosensors: Transduction Method, Redox Materials, and Bio-Interface. Modification of Glass Surfaces by Phosphorus Dendrimer Layers for Biosensors. Tethering Lipid Bilayers to Solid Supports. In vitro Synthesis of Membrane Proteins. Integrin-Functionalized Artificial Membranes as Test Platforms for Monitoring Small Integrin Ligand Binding by Surface Plasmon-Enhanced Fluorescence Spectroscopy. Wetting of Surfaces by Lipid Bilayers. Patterned Lipid Bilayers on Solid Substrate as a Model System of the Biological Membrane. Electrically Addressable, Biologically Relevant Surface Supported Bilayers. Nanopatterning of Biomolecules by Dip Pen Lithography. Surfaces for Stem Cell Propagation. Mechanical Cues for Cell Culture. Constructing Defined Networks of Neurons. Mineralization on a Biomimetic Surface.MO-CVD on patterned SAMs. Application of Biofunctional Surfaces in Medical Diagnostics. Nanopatterning for Bioapplications.

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Book SynopsisThis book illustrates a variety of challenges that bug hunters try to solve. It is an outstanding collection of the insights and expertise of an interdisciplinary group of researchers from all walks of life: virologists, physicians, immunologists, electrochemists, physicists, computer scientists, biotechnologists, epidemiologists, and molecular biologists, all working at the forefront of diagnostics in fields that cross scientific boundaries. Notwithstanding a dire moment as that of the recent Ebola outbreak in West Africa that saddens us all, we must more than ever peregrinate across oceans, and take the fight to them, as these invisible and exotic but deadly enemies know no barriers and constantly invade our lives. The coming epidemics and killer pandemics require us to continuously innovate in areas of prevention, detection, and therapy. The present volume focuses on creating virus alerts or hand-held detectors to bring to the field during an epidemic, when possible, or tools for the healthcare worker to rapidly diagnose the patient’s ailment. The authors describe the conventional cell cultures and molecular biology methodologies, while introducing state-of-the-art multidisciplinary biosensors. This book is not a manual, set of protocols, or a textbook; it is a glimpse into the advances of virus diagnostic research. Included are a variety of topics that encompass world health issues, local folklore such as associating outbreaks with witchcraft, problems in getting healthcare workers to the outbreak areas, and insights in viral diagnostic pitfalls.

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Book SynopsisThis book is a collection of essays by scientists, historians, philosophers of science, and students. The essays meld biotechnology into science fiction stories and thereby open a conversation about the morality of what we may be one day, and what it may mean to be human as our biotechnological endeavors continue to evolve. The biotechnology "revolution," launched on a global scale many decades ago, has taken a direct course toward re-creating life. Yet there are still many choices to be made in shaping the future that it may one day make possible. The book motivates readers toward deep reflection and continual discourse, which are essential if biotechnology is to evolve in ethical, meaningful, and sustainable ways.Table of ContentsIntroduction and History. Science-Story Dialectic as a Discourse of Change. History of the Biotechnology Revolution. Understanding Problems & Approaching Cures. The "Vicious Cycle" of Obesity. Madeline. Prion Diseases. Carnivore’s Game. Climate Change and the Future of Freshwater. Negotiations. Adult Stem Cells to Cure Diabetes-induced Vision Loss. Shadows, and Sugars, and Shades of Grey (Madeline, Part. 2). New Knowledge & New Capabilities. Neogenesis. Madness Enough to Break the World. Who Do They Think They Are? Emmanuel. Keys to Bioproducts from Agriculture. Soon They’ll Know our Secrets. Dr. Hyde. The Promise and Pitfalls of Cognitive Enhancement. Build Me a Memory. On We Go. To Where, Who Knows? The Uncertain Consequences of the Biotechnology Revolution. Rōnin. Closing Reflection on the Word "Revolution".

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Book SynopsisBiocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.Trade Review"This book provides an actual and comprehensive overview of industrial biocatalysis, written by top scientists from academia and industry. It highlights by means of many examples how biocatalysis increasingly contributes to making the different areas of the chemical industry more sustainable through fostering an ongoing development towards a more bio-based economy. The book is highly recommended to all scientists active in this field as an excellent source for further inspirations and in addition should greatly assist academic lectures in this field."—Prof. Yasuhisa Asano, Toyama Prefectural University, JapanTable of ContentsBiocatalysts: global market, industrial applications, aspects of biotransformation design and societal challenges. Making use of newly discovered enzymes and pathways: reaction and process development strategies for synthetic applications with recombinant whole-cell biocatalysts and metabolically engineered production strains. Directed evolution of enzymes for industrial biocatalysis. Strategies to overcome constraints in enzyme evolution and facilitate effective enzyme engineering. Production of functional isoprenoids through pathway engineering. Metabolic engineering for the bio-based conversion of CO2 to biofuels. Mixed microbial cultures for industrial biotechnology: success, chance, and challenges. Extremophiles and their use in biofuel synthesis. Industrial applications of halophilic microorganisms. Non-pathogenic Pseudomonas strains as a platform for industrial biocatalysis. Use of Corynebacterium glutamicum for the production of high-value chemicals from new carbon sources. Applications of enzymes in industrial biodiesel production. Promiscuous biocatalysts: Applications for synthesis from the laboratory to industrial scale. Micro-magnetic porous and non-porous biocatalyst carriers. Robust enzyme preparations for industrial applications. Hydrolases in non-conventional media: Implications for industrial biocatalysis. Enreductases from cyanobacteria for industrial biocatalysis. Cytochrome P450 biocatalysts: current applications and future prospects. Laccases: green biocatalysts for greener applications. Lipase-catalyzed epoxidation of fatty compounds and alkenes. Synthetic potential of dihydroxyacetone uilizing aldolases. The hydantoinase process: recent developments for the production of non-canonical amino acids. Biotechnological approaches to dipeptide production. Synthetic enzyme cascades for valuable diols and amino alcohols: smart composition and optimization strategies. Metabolic engineering for the biosynthesis of longevity molecules rapamycin and resveratrol. Detergent proteases. Industrial starch processing. Algae: a rich source of energy and high-value products. Enzyme-catalyzed processes in a potential algal biorefinery. Biocatalytic synthesis of polymers: a contribution to green chemistry. Bio-based chemicals and materials.

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Book SynopsisThis book is for readers with some background in science, concerning the search for drugs, starting from molecular diversity in nature or molecular wilderness. Drug molecules may be used as such, or as starting points for improved drugs obtained from the interface of chemistry and biology. In some cases, the essential molecular features for drug properties from natural molecules may be identified and modified to more effective ones. In other cases, nature provides the targets, such as essential enzymes from infectious microorganisms, from which synthetic drugs can be designed. The mechanisms of action of drugs can be discerned by studying target–drug interactions. Nature may fight back, as in cases when microorganisms become resistant to drugs, but we can again use the chemistry–biology interface to obtain drugs which overcome the resistance. The battle goes on, hopefully with victory for both humans and balance of nature. This book differs from those available on the subject of natural products and drugs derived therefrom in that it looks at the broad picture on how materials and organisms from nature affect our health and how we have combined our knowledge in chemistry, biology, and biodiversity to promote our wellness from resources in the "molecular wilderness," with caveats on sustainable utilization of these resources. It is therefore suitable, not only for readers interested in science and medicine, but also for those with interest in policy issues concerning sustainable development, environment, and issues concerning interaction of science and society in general.Trade Review"Writing a popular science book is more challenging than writing a professional one for the technical audience. One needs to be scientifically rigorous, yet speak in the language of the school student and the ‘lay’ public. There can be no threatening equations or complex chemical pathways, yet one should convey the message in a lucid manner. Professor Yuthavong carries it off with ease and elan. He has chosen the word "wilderness" deliberately, to evoke both excitement and awe in the reader. He shows how human creativity is able to chisel molecules from wilderness into useful products, how nature itself has been doing such molecular architecture over evolution, and how we may learn from it. The underlying message, expressed with time honored wisdom, is Gandhian in spirit. Recall what Mahatma Gandhi said: ‘Nature provides for man’s need, but not his greed’, and ‘Be the change you want the world to be’. This is a book that needs to be distributed across both the developing and developed worlds." — D. Balasubramanian, Professor and Director of Research, L V Prasad Eye Institute, Hyderabad, India, and UNESCO Kalinga Prize Laureate in Science Popularization"I very much like the idea of writing something that's technically correct but intended for a general audience. The topics would correct an impression that all drug discovery these days comes from high throughput screening of synthetic molecules. I’m very impressed with the variety of topics the writer has managed to touch upon and with how technically accurate the handling of these topics has been."— Jon Clardy, Professor, Harvard Medical School and Broad Institute, USA"This pioneering book is a powerful source of enlightenment on the vital connections between the diversity world's biological splendour and advancement of scientific knowledge. It offers a convincing case as to why the conservation of biological diversity is imperative for human wellbeing. I recommend it to anyone who has an interest in sustainable development in general and environmental protection in particular."— Calestous Juma, Professor, Harvard Kennedy School, USA, and Former Executive Secretary, United Nations Convention on Biological Diversity"This is an excellent reading not only for researchers and students but also for general readers. The whole book is woven around the key term ‘wilderness’. It covers a wide area of subjects, from ancient myth to modern molecular biology and drug design. The book is not only educational but also highly entertaining. I hope in the future it will be available to those people who do not understand English."— Hisao Masai, Professor, Tokyo Metropolitan Institute of Science and University of Tokyo, Japan"The need to bring together new knowledge in basic sciences, agriculture, anecdotes and cultural norms on a single platform for efforts in prospecting for drugs from natural products cannot be overemphasized. Many have attempted to do this but only a few have the background necessary to succeed in the efforts. Professor Yongyuth brings with him a wealth of knowledge accumulated over thirty years and is probably the best to produce a much needed balanced view in the field."— Ayoade Oduola, Former Deputy Director, UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland"Professor Yongyuth Yuthavong has worked for decades at the highest levels of science and government and successfully cross pollinated these worlds. So it’s no surprise that his new book, Tapping Molecular Wilderness: Drugs from Chemistry–Biology–Biodiversity Interface, bridges the worlds of science and nature. Coming at the moment when the world is embarking on a new set of Sustainable Development Goals which also must embrace both science and nature, this book can be widely recommended for anyone who wishes to think more deeply about these goals—and the future of our world."— Peter Singer, Professor, University of Toronto, and Chief Executive Officer, Grand Challenges Canada"One thing that typifies the writer is his clarity in thinking and presentation: This quality is apparent in this highly readable book. Through hands-on drug research and involvement with related issues, he aims to make us appreciate nature for its cornucopia of simple and complex molecules that are beneficial to mankind. One such benefit is the natural products for combating pathogenic organisms whose drug resistance should be taken seriously by our making sustained and renewed efforts to fight them. After all pathogens must fight for their lives; simplistic and ephemeral efforts by the medical community have constantly proved to be inadequate. In this book the themes of the need to sustain nature for its biodiversity and to combat pathogens by natural and modified biomolecules shine through brilliantly."— Bhinyo Panijpan, Former Director, Institute for Innovative Learning, Mahidol University, Thailand"The author beautifully portraits the biodiverse ‘molecular wilderness’ as the world of wonder, full of treasure to benefit mankind. Complex chemistry of drug discovery and drug design is amazingly made simple. It ends with a strong message that molecular wilderness is powerful. We must respect its balance and coexist with it sustainably. Otherwise it fights back harshly. The book is very educational and inspiring. It is a complex scientific textbook neatly made simple for general readers. We definitely need more science and technology books in this literary style."— Khunying Sumonta Promboon, Member of Thai National Legislative Assembly and Former President of Srinakarinwirote University, Thailand"Living organisms produce both toxic compounds to disable their predators and beneficial compounds to protect or heal themselves, so as to enhance their ability to survive. So Nature, or the ‘Wilderness’, is a rich source of medically important molecules. Thus ‘Tapping the Molecular Wilderness’ has played a crucial role in the discovery of new drugs to combat human illnesses, such as infection and heart disease. The author elegantly discusses the principles of drug discovery, the need for an integrated role of chemistry and biology, novel strategies in research, as well as problems arising from drug resistance. As expert researcher, with success in devising a novel drug for malaria, the author has simplified the scientific concepts, historical perspectives and modern trends in drug discovery in a simplified manner, readily understood by the layman. More books like this are needed to show the importance of research, not only at applied level but also at basic level: Perhaps then governments, especially in developing countries, may invest more in research for the future."— M. R. Jisnuson Svasti, Emeritus Professor, Mahidol University and Chulaborn Research Institute, Thailand"The author should be admired for his bold effort to write a book on ‘natural science’ for the general public. As it turns out, this book not only contains a wealth of scientific information but also is very easy to read and to follow from the first page to the last. Readers will benefit from the knowledge given which can be used as a starting point to dig further into the ‘beauty of nature’. The author should be congratulated for the beautiful tale of science adventure."— Yodhathai Thebtaranonth, Emeritus Professor, Mahidol University, Thailand, and ASEAN Outstanding Technologist and Technologist Awardee, 1995"From the wilderness have come many revelations. Professor Yongyuth Yuthavong now has added chemistry to the list."— Prapon Wilairat, Professor, Mahidol University, Thailand, and Outstanding Scientist of Thailand Awardee, 1997Table of ContentsMolecular Wilderness Harsh and Healing. Gifts from Molecular Wilderness. Drug Targets from Molecular Wilderness. Molecular Wilderness as Templates for Drugs. The Wilderness Fights Back. Living with Molecular Wilderness.

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Book SynopsisProtein-mediated charge transport is of relevant importance in the design of protein-based electronics and in attaining an adequate level of understanding of protein functioning. This book reviews a variety of experiments devoted to the investigation of charge transport in proteins and presents a unified theoretical model to interpret macroscopic results in terms of the amino acids backbone-structure of the single protein. It aims to serve a broad audience of researchers involved in the field of electrical characterization of biological materials and in the development of new molecular devices based on proteins and also as a reference platform that surveys existing data and presents the basis for future development of a new branch of nano-electronics, which by mixing proteomics, that is, the large-scale study of proteins, particularly their structures and functions, and electronics is introduced here as proteotronics.Trade Review"This book presents the first structured approach to the new field of protein-based electronics, which has opened possibilities for the development of new concepts of nanobiosensors for health applications. It presents a solid theoretical approach which is validated by the existing experimental evidence, and will be of relevance for both young and experienced researchers who are interested in the frontier between electronics and biology."— Prof. Joan Bausells, Barcelona Microelectronics Institute (CSIC), Spain"This book presents a newly emerging discipline, proteotronics, investigating the coupling between the protein world and electronics. It opens the field of protein-based nanobiosensors that are able to bypass the complicated sequence of biological events for signal generation in e-sensing." — Prof. Nicole Jaffrezic-Renault, Institute of Analytical Chemistry, University of Lyon, France"Alfinito and her coworkers have made the very first steps of analyzing the electrical transport characteristics of the building elements of potentially important protein-based electronics. Highly recommended reading for all those who are involved with these developments and anybody who is interested in these challenging issues." — Prof. Lazlo B. Kish, Texas A&M University, USATable of ContentsPreface. Introduction. Sensing Proteins. Electrical Properties: Experiments. Electrical Properties: Theory. Bacteriorhodopsin as Testing Prototype. Survey of Other Proteins. Conclusion and Perspectives. Appendix: Computational Details. List of acronyms. Bibliography. Index.

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Book SynopsisNanobiocatalysis has rapidly developed into a subarea of enzyme biotechnology. It combines the advances in nanotechnology that have generated nanoscale materials of different sizes, shapes, and physicochemical properties, and the excellent characteristics of biocatalysts into an innovative technology. This book provides an overview of the various relations between nanotechnology and biocatalysis. It discusses the fabrication and application of nanomaterials for the immobilization of enzymes used in the sustainable production of goods and chemicals. Nanosupports have several advantages compared with bulk solid materials because of their high surface area, which results in a significantly reduced mass transfer limitation and comparatively high enzyme loading. These characteristics are also of great use for applications in the fields of enzymatic biosensors, biofuel cells, bioelectronics, and photoelectrochemical analyte detection, where conductive nanomaterials improve the rate of electron transfer. The book also presents an overview of nanotoxicology and covers nanostructured enzyme catalysis in organic solvents and its potential application for biodiesel production, probing of enzymatic activity, and identification of enzyme functions of inorganic nanoparticles as enzyme mimics.Table of ContentsFundamentals of Nanotechnology. Biocatalysis: An Introduction. Environmentally Benign Nanomaterial Synthesis Mediated by Culture Broths. Rational Design of Enzyme-Polymer Biocatalysts. Biological Strategies in Nanobiocatalyst Assembly. Graphene-Based Nanobiocatalytic System. Immobilization of Biocatalysts onto Nanosupports: Advantages for Green Technologies. Enzyme Immobilization on Membrane and Its Application in Bioreactors. Potential Applications of Nanobiocatalysis for Industrial Biodiesel Production. Enzymogel Nanoparticles Chemistry for Highly Efficient Phase Boundary Biocatalysis. Recent Advances in Nanostructured Enzyme Catalysis for Chemical Synthesis in Organic Solvents. Probing Enzymatic Activity by Combining Luminescent Quantum Dots, Gold Nanoparticles and Energy Transfer. FRET Reporter Molecules for Identification of Enzyme Functions. Quantum Dot Architectures on Electrodes for Photoelectrochemical Analyte Detection. Inorganic Nanoparticles as Enzyme Mimics. Enzyme Nanocapsules for Glucose Sensing and Insulin Delivery. Nanostructured Materials for Enzymatic Biofuel Cells. Enzymatic Biofuel Cells on Porous Nanostructures. Nanoplasmonic Biosensors. Enzyme Biocomputing: Logic Gates and Logic Networks to Interface and Control Materials. Functional Nano-Bio Conjugates for Targeted Cellular Uptake and Specific Nanoparticle–Protein Interactions. Cell-Free Expression–Based Microarrays: Applications and Future Prospects. Overview of the Current Knowledge and Challenges Associated With Human Exposure to Nanomaterials.

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Book SynopsisThis unique handbook (60 chapters) examines the entire "product life cycle," from the creation of nanomedical products to their final market introduction. While focusing on critical issues relevant to nanoproduct development and translational activities, it tackles topics such as regulatory science, patent law, FDA law, ethics, personalized medicine, risk analysis, toxicology, nano-characterization and commercialization activities. A separate section provides fascinating perspectives and editorials from leading experts in this complex interdisciplinary field.Table of ContentsSection I – Law, Business and Commercialization. Section II – Regulatory Issues and Nanogovernance. Section III – Health, Safety, Risk and Biological Interactions. Section IV – Future Implications, Ethics and Perspectives.

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Book SynopsisUnderstanding Enzymes: Function, Design, Engineering, and Analysis focuses on the understanding of enzyme function and optimization gained in the past decade, past enzyme function analysis, enzyme engineering, and growing insights from the simulation work and nanotechnology measurement of enzymes in action in vitro or in silico. The book also presents new insights into the mechanistic function and understanding of enzyme reactions, as well as touching upon structural characteristics, including X-ray and nuclear magnetic resonance (NMR) structural methods. A major focus of the book is enzyme molecules’ dependency on dynamic and biophysical environmental impacts on their function in ensembles as well as single molecules. A wide range of readers, including academics, professionals, PhD and master’s students, industry experts, and chemists, will immensely benefit from this exclusive book.Table of ContentsA practical guide to the quantitative analysis of engineered enzymes. Protein Conformational Motions - Enzyme Catalysis. Enzymology meets Nanotechnology: Single-molecule methods for observing enzyme kinetics in real time. Interfacial enzyme function visualized using neutron, x-ray and light scattering methods. Folding dynamics and structural basis of the enzyme mechanism of ubiquitin C-terminal hydroylases. Stabilisation of Enzymes by metal binding: Structures of Alkalophilic Bacillus proteinases and analysis of the second metal binding site of subtilases. Structure and Functional Roles of Surface Binding Sites in Amylolytic Enzymes. Interfacial Enzymes and their Interactions with Surfaces: Molecular Simulation Studies. Sequence, structure, function: What we learn from analyzing protein families. Bioinformatic analysis of protein families to select function-related variable positions. Decoding life secrets in sequences by chemicals. Role of tunnels and gates in enzymatic catalysis. Molecule descriptors for the structureal analysis of enzyme active sites. Hydration effects on enzyme properties in nonaqueous media analysed by MD simulations. Understanding esterase and amidase reaction specificities by molecular modelling. Towards new non-natural TIM-barrel enzymes using computational design and directed evolution approaches. Handling the Numbers Problem in Directed Evolution. Hints from Nature: Metagenomics in Enzyme Engineering. A functional and structural assessment of circularly permuted Bacillus circulans xylanase and Candida antarctica lipase B. Ancestral Reconstruction in Enzymes. High throughput screening or selection methods for evolutionary enzyme engineering. Nanoscale Enzyme Screening Technologies. Computational Enzyme Engineering: Activity Screening using Quantum Chemistry. In silico screening of enzyme variants by molecular dynamics simulation. Kinetic and thermodynamic stability of variant enzymes.

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Book SynopsisThis book contains fascinating vignettes depicting future societies and the implications which increasing technological change has on society and the environment. The topics discussed include nanotechnology, medicine, computational science, biotechnology, synthetic biology, and cognitive technology, among others in science. In addition, social norms, attitudes, and policy are also featured. The upshot of this combination is an entertaining, educational, and thought-provoking volume.The glimpses into future societies subsequent to the introduction and incorporation of various emerging technologies depict scenarios of how we view ourselves, how we view others, how we are viewed by others, how our surroundings are viewed, how our leaders and political structures are viewed, what our social and behavioral norms are, what our temperament/mood is, and so forth. The introduction features a focused discourse on current trends of the impacts of emerging technologies and the conclusion highlights where society should go from here.Trade ReviewSynopsis: Collaboratively compiled and co-edited by environmental scientists Nora Savage and Anita Street, "Flash Forward: A Series of Futuristic Vignettes" contains ten fascinating vignettes by experts in the field that depict future societies and the implications which increasing technological change has on society and the environment. The topics discussed include nanotechnology, medicine, computational science, biotechnology, synthetic biology, and cognitive technology, among others in science. In addition, social norms, attitudes, and policy are also featured. The upshot of this combination is an entertaining, educational, and thought-provoking volume of science based extrapolations.The glimpses into future societies subsequent to the introduction and incorporation of various emerging technologies depict scenarios of how we view ourselves, how we view others, how we are viewed by others, how our surroundings are viewed, how our leaders and political structures are viewed, what our social and behavioral norms are, what our temperament/mood is, and so forth. The introduction features a focused discourse on current trends of the impacts of emerging technologies and the conclusion highlights where society should go from here. Critique: Thoroughly 'reader friendly' in tone, commentary, organization and presentation, "Flash Forward: A Series of Futuristic Vignettes" is an informative, thought-provoking, compelling read and will prove to be a critically important addition to both community and academic library collections. It should be noted for the personal reading lists of students and non-specialist general readers with an interest in the subject that "Flash Forward: A Series of Futuristic Vignettes" is also available in a Kindle format. – Susan Bethany, Reviewer’s Bookshelf MagazineSynopsis: Collaboratively compiled and co-edited by environmental scientists Nora Savage and Anita Street, "Flash Forward: A Series of Futuristic Vignettes" contains ten fascinating vignettes by experts in the field that depict future societies and the implications which increasing technological change has on society and the environment. The topics discussed include nanotechnology, medicine, computational science, biotechnology, synthetic biology, and cognitive technology, among others in science. In addition, social norms, attitudes, and policy are also featured. The upshot of this combination is an entertaining, educational, and thought-provoking volume of science based extrapolations.The glimpses into future societies subsequent to the introduction and incorporation of various emerging technologies depict scenarios of how we view ourselves, how we view others, how we are viewed by others, how our surroundings are viewed, how our leaders and political structures are viewed, what our social and behavioral norms are, what our temperament/mood is, and so forth. The introduction features a focused discourse on current trends of the impacts of emerging technologies and the conclusion highlights where society should go from here. Critique: Thoroughly 'reader friendly' in tone, commentary, organization and presentation, "Flash Forward: A Series of Futuristic Vignettes" is an informative, thought-provoking, compelling read and will prove to be a critically important addition to both community and academic library collections. It should be noted for the personal reading lists of students and non-specialist general readers with an interest in the subject that "Flash Forward: A Series of Futuristic Vignettes" is also available in a Kindle format. – Susan Bethany, Reviewer’s Bookshelf MagazineTable of ContentsIntroduction. Ahead of Time. Annual Meeting. California Dreamin’. Intelligence on Earth? Manipulations at the Nanoscale. Message to Earth. The Failed Life of Reverend Bayes. Arachnophobia. Are Ye Gods? The Path.

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Book SynopsisThis book presents basic information about DNA, along with comprehensive theoretical introduction to DNA. It discusses recent developments in divalent-metal-ion inserted M-DNA complex, which gives rise to the possibility of DNA application to electronic functionality. Further, the book describes three examples of applications: optical and electrical materials, electronic devices such as bioTFT memory and color-tunable light-emitting diodes, and biofuel cell application with use of proton conduction in DNA. Table of ContentsIntroduction. Basic physical properties of natural DNA. Infrared spectral studies on structure and hydration state of dry DNA. Proton conduction in DNA. X-ray absorption spectroscopy. Hückel calculation for the electronic states of DNA. Basic property of M-DNA. IR spectral studies on M-DNA. Charge doping in Zn-DNA. Structure of M-DNA with STM. DNA as a material. Application of DNA to electronic devices. Fabrication and characteristics of DNA-biofuel cell.

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Book SynopsisNanomedicine can take advantage of the recent developments in nanobiotechnology research for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles, and improved accumulation at the disease site. This book provides a broad glimpse of how various dendritic nanomaterials have been designed and used as efficient tools for nanomedicine. It comprises a pedagogic introduction to dendrimers and hyperbranched systems and their classical and accelerated syntheses through cutting-edge methodologies. The chapters on dendronized magnetic nanoparticles as theranostics, dendrimers in theory (molecular simulations), siRNA delivery with dendrimers, and dendrimers for image-guided therapy, combined with chapters focused on specific types of dendrimers or hyperbranched structures, detail the cutting-edge research in nanomedicine. Finally, a detailed chapter on issues related to the pharmacokinetics and biodistribution of dendrimers helps choose the right structures for successful transfer from bench to bedside. This book will appeal to those involved in nanobiotechnology, macromolecular science, cancer therapy, tissue repair, and siRNA delivery research.Trade Review"Dendrimers in Nanomedicine is a timely, well-edited as well as masterly crafted book written by experts in the field. Although dendrimers were originally proposed to be a cure-all for medicine, it has taken longer than expected to fully appreciate their inherent structural shortcomings as well as potential. With new, novel architectural designs and their availability for critical in-depth in vitro and in vivo testing, the innovative roles of dendrimers in nanomedicine are explored. This book describes the impact of the first three decades of tunable dendritic architectures designed and constructed for nanomedicine, and their future is inspirational. It is a must-read for anyone in the supramolecular polymer/medical arena."—Prof. George R. Newkome, University of Akron, USA"Since the first report by Donald Tomalia in 1991, R&D on dendrimers has made exponential progress as a mainstay of nanomedicine. Now close to 7000 articles have been published on dendrimer research. This book covers the research and applications of various dendrimers very well—from their chemistry to their practical medical applications. Therefore, it will be a very good reference for graduate students and expert researchers in the field."—Dr. Hisataka Kobayashi, National Cancer Institute, USA"Dendrimers in Nanomedicine is a timely, well-edited as well as masterly crafted book written by experts in the field. Although dendrimers were originally proposed to be a cure-all for medicine, it has taken longer than expected to fully appreciate their inherent structural shortcomings as well as potential. With new, novel architectural designs and their availability for critical in-depth in vitro and in vivo testing, the innovative roles of dendrimers in nanomedicine are explored. This book describes the impact of the first three decades of tunable dendritic architectures designed and constructed for nanomedicine, and their future is inspirational. It is a must-read for anyone in the supramolecular polymer/medical arena."—Prof. George R. Newkome, University of Akron, USA"Since the first report by Donald Tomalia in 1991, R&D on dendrimers has made exponential progress as a mainstay of nanomedicine. Now close to 7000 articles have been published on dendrimer research. This book covers the research and applications of various dendrimers very well—from their chemistry to their practical medical applications. Therefore, it will be a very good reference for graduate students and expert researchers in the field."—Dr. Hisataka Kobayashi, National Cancer Institute, USATable of ContentsGeneral introduction: classical versus accelerated syntheses of dendrimers. Dendrimer-nanoparticle conjugates. Dendritic polymers for the repair of tissues. Polyglycerols in Nanomedicine. Theranostic dendronized iron oxide nanoparticles. Anti-inflammatory dendrimers. Dendrimers for siRNA delivery. Dendrimers in cancer therapy. Dendrimer pharmacokinetics and biodistribution. Molecular modeling of dendrimers.

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Book SynopsisThis book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage a reality. The movie is about a submarine and its crew members being shrunk to microscopic size and ventured into the body. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie while explaining how it is implemented in this first-of-a-kind interventional facility.This is the first book that explains the fundamentals of navigation of therapeutic agents in the vascular network. The scope of the book is twofold: (1) to initiate readers into various technologies, including, but not limited to, nanotechnology, robotics, and biochemistry (more importantly, it shows how critical the integration of all these disciplines is to solving problems that indeed require a multidisciplinary environment); (2) to inspire the younger generation by showing that science and technology can bring one everywhere with the power to transform fiction to reality that can help humankind.Table of ContentsIntroduction. The location. The interventional facility. The team at the planning briefing. The submarine. Miniaturization. Injection. Travelling in the artery. Tracking the position of the submarine. Propulsion and steering. Navigating in the bloodstream. The crew. Conclusion.

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Book SynopsisChapter 1. Introduction to Freeze Drying, its Operation, and the Different Types of Freeze Dryers.- Chapter 2. Development of the Freeze-Drying Cycle, Cryoprotectant Selection, and Characterization.-Chapter 3. New physical methods for characterization of freeze-dried goods.- Chapter 4. Impact of Freeze-Drying on Pharmaceutical Product’s Morphology, Physical Characteristics, and In Vitro Release Kinetics.- Chapter 5. Stability of Colloidal Dispersions Using Freeze-Drying Technology.- Chapter 6. Progress and Challenges in Enhancing the Stability of Targeted Drug Delivery Vehicles.-Chapter 7. Use of Freeze Drying for Pharmaceutical Microencapsulation.- Chapter 8. Freeze drying of Pharmaceutical products for injectable and oral use.- Chapter 9. Palatalisation of pharmaceuticals using freeze-drying technology.- Chapter 10. Solid-state delivery and stabilization of therapeutic proteins using freeze-drying technology.- Chapter 11. Using Freeze-Drying to Stabilize Formulations of Monoclonal Antibodies.- Chapter 12. Freeze Drying of Vaccines to Increase Immunity.- Chapter 13. Enhanced Preservation of Stem Cell-Derived Extracellular Vesicles Through Freeze-Drying.- Chapter 14. Development of a hydrogel-nanofibrous scaffold via freeze-drying.- Chapter 15. Freeze-drying: Increasing probiotic stability.

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