Biotechnology Books

Book SynopsisCHAPTER 1.  Ocular drug delivery: introduction and fundamental concept.- CHAPTER 2. Eye: anatomy, physiology and disease.- CHAPTER 3. Drug delivery to the anterior segment of eye.- CHAPTER 4. Drug delivery to the posterior segment of eye.- CHAPTER 5. Fixed-dose combination approach in therapeutic delivery to the eye.- CHAPTER 6. Role of preservatives in ophthalmic products.- CHAPTER 7. Reverse engineering in complex/combination ophthalmic product.- CHAPTER 8. Role of quality by design (qbd) in ophthalmic products.- CHAPTER 9. Advances and opportunities of the novel functional nanocarriers.- CHAPTER 10. Safety and toxicities of nanocarriers in ophthalmic drug delivery system.- CHAPTER 11. Validation in sterile ophthalmic formulation.- CHAPTER 12. Packaging, container and closure of ophthalmic products.- CHAPTER 13. Regulatory perspectives in ophthalmic products.- CHAPTER 14. Polymeric microsponges for drug delivery to ocular candidiasis infections: preclinical and clinical evidences.

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Book SynopsisChapter 1. Significance influence of microbial biodiversity in biotechnological and industrial sectors.- Chapter 2. Significance and contribution of Microbial biodiversity in Various Biotechnological and Industrial Sectors.- Chapter 3. Fundamentals and industrial applications of modern genetic engineering.- Chapter 4. Omics role and its integration to modern-day technologies: Identification in production of industrially relevant bioproducts.- Chapter 5. Impact study of gene expression: Osmotic control, SOS response and heat shock response.- Chapter 6. Significance of microbial biomolecules, secondary metabolites and its impact on diverse aspects of human health.- Chapter 7. Molecular approaches to microbial identification of industrially significant strains.- Chapter 8. Emerging trends in novel technological advancements of oligosaccharides production and their potential applications as prebiotics with beneficial effects.- Chapter 9. Processed Food Microbiology and Safety: Risks, Tr

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Book SynopsisTable of ContentsPart 1: Materials Science and Engineering Section 1.2 Properties of Materials Section 1.3 Classes of Materials Used in Medicine Section 1.4: Materials Processing Part 2: Biology and Medicine Section 2.1 Some Background Concepts Section 2.2 Host Reaction to Biomaterials and Their Evaluation Section 2.3 Characterization of Biomaterials Section 2.4 Degradation of Materials in the Biological Environment Section 2.5 Applications of Biomaterials Section 2.6 Applications of Biomaterials in Functional Tissue Engineering Part 3: The Medical Product Life Cycle Appendix A: Properties of Biological Fluids Appendix B: Properties of Soft Materials Appendix C: Chemical Composition of Metals and Ceramics Used for Implants Appendix D: The Biomaterials Literature Appendix E: Assessment of Cell and Matrix Components in Tissues (Online only)

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Book SynopsisGenetic Engineering: A Primer presents the growing field of biotechnology to non-science majors and other general interest readers. The author examines the natural forces that change genetic information and the ways in which scientists have learned to engineer these genetic changes. With a wealth of information flooding the popular press, including news and controversy surrounding cloning, Genetic Engineering is a timely volume that provides background information to the reader intent on understanding this fascinating development.Table of ContentsBuilding Blocks of Living Things. Matter and Living Things. Proteins. Nucleic Acid. How Living Things are Changed. Making and Altering Proteins. Altering Genetic Material in Bacteria. Genetically Engineering Bacteria. Viruses. Making Genetic Changes in Plants and Animals. Placing New Genes in Mammalian Cells. Genetic Engineering of Plants. Embryo Transfers and Cloning of Animals. How Genetic Engineering Helps Us. Gene Therapy and Disease. Other Applications for Gene Therapy. Biotechnology, Safety, and the Future. Glossary. Appendix.

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Book SynopsisNuclear Magnetic Resonance spectroscopy is a dynamic way for scientists of all kinds to investigate the physical, chemical, and biological properties of matter. Its many applications make it a versatile tool previously subject to monolithic treatment in reference-style texts. Based on a course taught for over ten years at Brandeis University, this is the first textbook on NMR spectroscopy for a one-semester course or self-instruction. In keeping with the authors' efforts to make it a useful textbook, they have included problems at the end of each chapter.The book not only covers the latest developments in the field, such as GOESY (Gradient Enhanced Overhauser Spectroscopy) and multidimensional NMR, but includes practical examples using real spectra and associated problem sets. Assuming the reader has a background of chemistry, physics and calculus, this textbook will be ideal for graduate students in chemistry and biochemistry, as well as biology, physics, and biophysiTable of Contents1. What Is Spectroscopy? 2. Elementary Aspects of Nuclear Magnetic Resonance (NMR) 3. Elementary Aspects of NMR II: Fourier Transform NMR 4. Nuclear Spin Relaxation and the Nuclear Overhauser Effect 5. Classical and Quantum Descriptions of NMR Experiments in Liquids 6. Density Operator and Product Operator Descriptions of NMR Experiments in Liquids 7. Homonuclear Two-Dimensional NMR Experiments and Coherence Selection 8. Heteronuclear Correlations in NMR 9. Building Blocks for Multidimensional NMR and Special Considerations for Biological Applications of NMR 10. NMR under Anisotropic Conditions: NMR in the Solid State and Ordered Fluids 11. Relaxation Revisited: Dynamic Processes and Paramagnetism 12. Diffusion, Imaging, and Flow

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Book SynopsisThe present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.Table of ContentsApplications of Nano-Based Biomaterials. Nanocoutured Metallic Biomaterials and Surface Functionalization of Titanium-based Alloys for Medical Applications. Graphene-Polymer Nanocomposites for Biomedical Applications. Lipid-based Nanocarriers in Lymphatic Transport of Drugs: Retrospect and Prospects. Nanotechnology in Early Diagnosis of Cancer. Dendrimers: Emerging Anti-Infective Nanomedicines. Production and Utilization of Nanofibers. Fibro-Porous Composite Nano-Biomaterials for Enhanced Bio-Integration. Nanocarriers Mediated Protein Delivery. Nanotechnology-Based Prodrug Conjugates for Site-Specific Antineoplastic Therapy. Osteomyelitis: Therapeutic Management using Nanomedicines.Nanostructured Lipid Carriers-Mediated Methotraxate Delivery Evokes Transcription Factors to Induce Selective Apoptosis in Rheumatoid Arthritis.Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications. Development of In-house Nano-hydroxyapatite Particles for Dental Applications.

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Book SynopsisThe Metal Ions in Biological Systems series is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Written by 36 internationally recognized experts and enriched with nearly 200 illustrations, Volume 40 highlights fast moving research on lanthanides and their interrelations with biosystems and emphasizes their recent impact in biochemical and biological studies, and in medicine. Table of ContentsDistribution of the Lanthanides in the Earth's Crust; Mobilization of Lanthanides through the Terrestrial Biosphere; Complexes of Lanthanide Ions with Amino Acids, Phosphates, and Other Ligands of Biological Interest in Solution; Biologically Relevant Structural Coordination Chemistry of Simple Lanthanide Ion Complexes; Lanthanide Ions as Probes in Studies for Metal Ion-Dependent Enzymes; Lanthanide Chelates as Fluorescence Labels for Diagnostics and Biotechnology; Responsive Luminescent Lanthanide Complexes; Lanthanide Ions as Probes of Electron Transfer in Proteins; Lanthanide Ions as Luminescent Probes of Proteins and Nucleic Acids; Lanthanide-Promoted Peptide Bond Hydrolysis; Lanthanide-Catalyzed Hydrolysis of Phosphate Esters and Nucleic Acids; Sequence-Selective Scission of DNA and RNA by Lanthanides and Their Complexes; Lanthanide Ions as Probes for Metal Ions in the Structure and Catalytic Mechanism of Ribozymes; Lanthanides as Shift and Relaxation Agents in Elucidating the Structure of Proteins and Nucleic Acids; Lanthanide Ions as Magnetic Resonance Imaging Agents. Nuclear and Electronic Relaxation Properties. Applications; Interactions of Lanthanides and Their Complexes with Proteins. Conclusions Regarding Magnetic Resonance Imaging.

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Book SynopsisPreparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compounds. The book contains theoretical background, chemical principles, and relevance of preparative layer chromatography (PLC) to a wide range of applications, particularly in the study of pharmaceuticals and biochemistry. Written by many of the best known and most knowledgeable specialists in the field, the chapters describe all the necessary techniques, current procedures, and superior strategies for selecting the most suitable eluents and designing application-specific PLC systems based on the data being sought. They provide comprehensive instructions, surrounding issues, and suggestions for optimizing optional working techniques withiTrade Review"...A valuable and important supplement to the existing vast chromatographic literature, [this book] demonstrates the potential of planar chromatography for separation and isolation of pure compounds, even from very complex mixtures."-Journal of Liquid Chromatography, August 2006"The contributor[s']...experience integrated in the monograph forms a good basis for the readers."-Instrumentation Science & Technology, August 2006"The [first] eight chapters provide sound theoretical and methodological foundations of PLC. Numerous applications of PLC are reviewed in the second section, based on extensive literature. ...The application reviews provide numerous examples of solving experimental difficulties for the separation of complex mixtures."-Preparative Biochemistry & Biotechnology, August 2006"The book is quite well produced and has a large number of illustrations . . . this volume is a worthy addition to the PLC literature, and a good place to start for the novice." – I.D. Wilson, in Chromatographia, January 2008, Vol. 67, No. 1/2Table of ContentsIntroduction. Adsorption Planar Chromatography in the Non-linear Range: Selected Drawbacks and Selected Guidelines. Sorbents and Precoated Layers in PLC. Selection and Optimization of the Mobile Phase for PLC. Sample Application and Development of Layers. On Methodical Possibilities of the Horizontal Chambers in PLC. Location of Separated Zones by Use of Visualization Reagents, UV Absorbance on Layers Containing a Fluorescent Indicator, and Densitometry. Additional Detection Methods for Separated Zones and Recovery of Substances from the Layer. Medical Applications of PLC. PLC of Hydrophobic Vitamins. PLC of Natural Mixtures. Application of PLC to Lipids. The Use of PLC for Separation of Natural Pigments. Application of PLC to Inorganics and Organometallics. PLC in a Clean-up and Group Fractionaction of Geochemical Samples: A Review of the Commonly Applied Techniques. The Use of PLC for Isolation and Identification of Unknown Compounds from the Frankincense Resin: Strategies for Finding Marker Substances.

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Book SynopsisBook initiates with introductory material to hemodialysis technology and its historical evolution and later on divulging into the field of biomaterials. With this background, the book discusses selection criteria of a suitable biomaterial for synthesis of haemodialysis membranes along with illustration of a complete indigenous, low cost technology for spinning of haemodialysis fibres. Well illustrated description of instruments used for membrane characterization and biomedical engineering is also provided at suitable junctures to effectively present the concept including worked out examples. Present title can be a good textbook as well as a research material for membrane as well as biomedical engineering curricula and provides coverage for appropriate undergraduate and graduate students interested in hemodialysis membranes.Table of Contents1.Kidney Function and Uremia. 2. Evolution of Hemodialysis Technology. 3.Biocompatibility and Biomaterials. 4. Selection of Material for Dialysis Membrane. 5. Spinning of Dialysis Grade Membranes. 6. Post Processing of Dialysis Membranes. 7. Mathematical Modeling of Dialysis. 8. Economics of Dialyzer Manufacturing and Commercialization. 9. Conclusion : Future Trends and Scope

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Book SynopsisA Readily Applicable Framework for Novel Drug DesignIt is only 20 years since the reach of genetic knowledge has allowed for the development of protein biotherapeutics, but in that time the pace has been fast. While the literature abounds, the field has lacked a comprehensive accounting of this progress. Emerging Protein Biotherapeutics consolidates current knowledge of key protein targets important in autoimmunity and cancers, exploring basic aspects and diverse clinical application. Presents Strategies to Exploit Therapeutic UsesIn this volume, leading researchers cover many aspects of biology related to protein targets, ranging from the in vivo role in the disease process, to various strategies exploiting development of these targets for therapeutic use. Each chapter includes background, a discussion of clinical implications, an account of preclinical and clinical testing of various candiTable of ContentsINTRODUCTION. Overview of Antibody-Based Therapeutics: Present and Future Promise. BIOLOGICS FOR AUTOIMMUNITY AND INFLAMMATION. Biologic Therapies for Multiple Sclerosis. Biologic Therapies in Rheumatoid Arthritis. Biologic Therapies in Systemic Lupus Erythematosus. Biologic Therapies for Inflammatory Bowel Disease. Biologic Therapies for Psoriasis. TNFa Inhibitors: Emerging Biologic Therapies for the Treatment of Asthma. Protein-Based Therapies in Experimental and Clinical Transplantation. Biologic Therapies for Type 1 Diabetes. BIOLOGICS FOR HEMATOLOGICAL MALIGNANCIES. Biologic Therapies for Acute Myeloid Leukemia/Myelodysplastic Syndrome. Biologic Therapies for Non-Hodgkin Lymphoma and Hodgkin Disease. Biologic Therapies for Chronic Lymphocytic Leukemia. Biologic Therapies for Multiple Myeloma and Plasma Cell Disorders. DEVELOPMENT OF BIOTHERAPIES FOR SOLID TUMORS. Antibody-Based Therapies for Carcinomas. Role of Vascular Targeting Agents in the Treatment of Solid Tumors: Current and Future Developments. Recent Advancements in the Use of Antibody–Drug Conjugates for Cancer Therapy. INDEX.

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Book SynopsisDefinitive Treatment of the Numerical Simulation of Bioheat Transfer and Fluid FlowMotivated by the upwelling of current interest in subjects critical to human health, Advances in Numerical Heat Transfer, Volume 3 presents the latest information on bioheat and biofluid flow. Like its predecessors, this volume assembles a team of renowned international researchers who cover both fundamentals and applications. It explores ingenious modeling techniques and innovative numerical simulation for solving problems in biomedical engineering.The text begins with the modeling of thermal transport by perfusion within the framework of the porous-media theory. It goes on to review other perfusion models, different forms of the bioheat equation for several thermal therapies, and thermal transport in individual blood vessels. The book then describes thermal methods of tumor detection and treatment as well as issues of blood heating and cooling duTable of ContentsSynthesis of Mathematical Models Representing Bioheat Transport. Numerical Models of Blood Flow Effects in Biological Tissues. Numerical Methods for Solving Bioheat Transfer Equations in Complex Situations. Discrete Vasculature (DIVA) Model Simulating the Thermal Impact of Individual Blood Vessels for In Vivo Heat Transfer. Numerical Bioheat Transfer in Tumor Detection and Treatment. Thermal Interactions between Blood and Tissue: Development of a Theoretical Approach in Predicting Body Temperature during Blood Cooling and Rewarming. Experimental and Numerical Investigation on Simulating Nanocryosurgery of Target Tissues Embedded with Large Blood Vessels. Whole-Body Human Thermal Models. Computational Infrastructure for the Real-Time Patient-Specific Treatment of Cancer. A Mathematical Model to Predict Tissue Temperatures and Necrosis during Microwave Thermal Ablation of the Prostate.

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Book SynopsisA Step-by-Step Guide to Describing Biomolecular StructureComputational and Visualization Techniques for Structural Bioinformatics Using Chimera shows how to perform computations with Python scripts in the Chimera environment. It focuses on the three core areas needed to study structural bioinformatics: biochemistry, mathematics, and computation.Understand Important Concepts of Structural BioinformaticsThe book covers topics that deal primarily with protein structure and includes many exercises that are grounded in biological problems at the molecular level. The text encourages mathematical analysis by providing a firm foundation for computations. It analyzes numerous Python scripts for the Chimera environment, with the scripts and other material available on a supplementary website.Build Python Scripts to Extend the Capabilities of ChimeraThrough more than 60 exercises that involve the develTrade Review"This book supports an approach to bioinformatics that balances biological problems, mathematical modeling, and computational tools. It breaks down the mathematical complications into manageable parts and augments programming skills while developing biological insight."—L. Ridgway Scott, Louis Block Professor of Computer Science and Mathematics, Member of the Institute for Biophysical Design, Senior Fellow of the Computation Institute, University of Chicago"This book is a useful resource for experienced and newcomer Chimera users alike. It helps extend it programmatically, allowing users to perform any number of useful types of calculations that are often required in conjunction with visualization. From distances to graphs, any way you measure it, Prof. Burkowski’s book is a must have for Chimera users."—Rafael Najmanovich, PhD, Associate Professor, Université de Sherbrooke"Structural bioinformatics is a young science that lies at the crossroads of several synergizing disciplines, including biophysics, structural biology, mathematical modeling, and computational methods. In this context, the book by Forbes Burkowski constitutes a true landmark, enabling the practitioner to implement and exploit computational techniques to test the mathematical models and frame novel hypothesis. This engrossing book is directed at advanced undergraduates and professionals who seek to represent and explore novel structural concepts to describe biomolecular phenomena. Very useful practical applications of the computational techniques presented in the book are likely to emerge, especially in the fields of molecular engineering and structure-based drug design. Thus, I predict that the book will become mandatory for researchers interested in rational design in the pharmaceutical industry and materials science."—Ariel Fernandez, Ph.D., Former Hasselmann Professor of Bioengineering at Rice University and Pioneer of the Wrapping Technology in Drug Design"Students taught with Computational and Visualization Techniques for Structural Bioinformatics Using Chimera will gain not only a thorough understanding of the important concepts of structural bioinformatics, from the basics of protein structure through advanced topics such as molecular mechanics, but also the ability to perform their own analyses using the programming techniques and libraries offered by this book and its supporting materials. The exercises are engaging and vary from problems that can be solved in a few minutes to mini-projects that might require a week of effort. All concepts are clearly described and accompanied by helpful illustrations where needed. This text does an excellent job of turning students into investigators."—Eric Pettersen, UCSF Department of Pharmaceutical ChemistryTable of ContentsIntroduction: Macromolecules and Chimera. Accessing and Displaying Molecular Data with Chimera. Algorithms Dealing with Distance. Algorithms Dealing with Angles. Structure Overlap and Alignment. Potential Energy Functions. Rotamers and Side‑Chain Conformation. Residue Networks. Appendices. Index.

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