Biomedical engineering / Medical engineering Books

Book SynopsisECHNOLOGICAL PROSPECTS AND SOCIAL APPLICATIONS SET Coordinated by Bruno SalguesThere are many controversies with respect to health crisis management: the search for information on symptoms, misinformation on emerging treatments, massive use of collaborative tools by healthcare professionals, deployment of applications for tracking infected patients. The Covid-19 crisis is a relevant example about the need for research in digital communications in order to understand current health info communication.After an overview of the challenges of digital healthcare, this book offers a critical look at the organizational and professional limits of ICT uses for patients, their caregivers and healthcare professionals. It analyzes the links between ICT and ethics of care, where health communication is part of a global, humanistic and emancipating care for patients and caregivers. It presents new digitized means of communicating health knowledge that reveal, thanks to the Internet, a competition between biomedical expert knowledge and experiential secular knowledge.Table of ContentsPreface xiOlivier GALIBERT and Benoit CORDELIER Acknowledgments xxixBenoit CORDELIER and Olivier GALIBERT Author Biographies xxxi Introduction xxxv Benoit CORDELIER and Olivier GALIBERT Part 1. Digital Patient Records: Organizational Adaptations 1 Chapter 1. Paradoxical Changes and Injunctions in an Implementation Project of the Digital Patient Record 3Benoit CORDELIER, Hélène ROMEYER, Laurent MORILLON and Olivier GALIBERT 1.1. Introduction 3 1.2. Organizational paradoxes and paradoxical injunctions 4 1.2.1. Organizational development and paradoxes 4 1.2.2. Discursive approaches to the organizational paradox 5 1.2.3. The pragmatic paradox: a return to the systemic approach of Palo Alto 5 1.2.4. What divergences and convergences? 8 1.3. A case study of an implementation project for digital patient records 11 1.4. Resolving the organizational paradox at the individual level 13 1.4.1. The injunction to internal mediation: role syncretism 13 1.4.2. The injunction to disappear: exit or integration 14 1.5. Conclusion 14 1.6. References 16 Chapter 2. Identifying Caregiver Practices by Analyzing the Use of Electronic Medical Records 21Pénélope CODELLO, David MORQUIN, Ewan OIRY and Roxana OLOGEANU-TADDEI 2.1. Introduction 21 2.2. Review of the management science literature on professional practices and uses of electronic patient records 23 2.3. Professional practices and the use of tools at the heart of the conceptual framework: the “instrumental genesis” 25 2.4. Methodology 26 2.4.1. Presentation of the case 27 2.4.2. Data collection and analysis methods 28 2.5. Results 30 2.5.1. Technical dimension of uses 30 2.5.2. System of instruments 32 2.5.3. Relationship with activity, with oneself and with others in the use of EMRs 33 2.5.4. Debates on the common good 36 2.6. Conclusion 37 2.7. References 39 Chapter 3. Communication Approach to Patients’ Health Work: Remote Relationship and Intertwined Powers 43Anne MAYÈRE 3.1. Introduction 43 3.2. Reconstructing patients’ work 45 3.2.1. Recomposed and multiplied patients’ work 47 3.2.2. Relationship of care and intertwined “pastoral and disciplinary powers” 51 3.3. Field and method 52 3.4. Remote relationship and intertwined powers 53 3.4.1. Establishing the relationship and learning to talk about oneself 54 3.4.2. Intertwined disciplines 56 3.5. Conclusion 58 3.6. Acknowledgments 59 3.7. References 59 Part 2. Care and Social Support: From Institutional Responses to Online Support 63 Chapter 4. The Place of Care in the E-coordination of Home Care and Assistance 65Géraldine GOULINET FITÉ 4.1. Introduction 65 4.2. Home care coordination issues 66 4.2.1. Reconfigurations at home 67 4.2.2. From computerization to health informatization 70 4.3. Impacts on the logic of care, roles and identities 73 4.3.1. From cure to care 73 4.3.2. Informational and communicational approach to care 74 4.4. Uses and practices of the PAACO-Globule dispositive in a support network for the coordination of complex pathways in the South Gironde region 77 4.4.1. Presentation of Escale Santé 77 4.4.2. Presentation of the PAACO-Globule solution: functionalities and organizational framework 79 4.4.3. Study design and presentation of results 80 4.5. Conclusion 87 4.6. References 89 Chapter 5. Breast Cancer Prevention Online in a Crisis of Confidence Context: From Medical–Technical Discourse to Social Support 95Dorsaf OMRANE and Pierre MIGNOT 5.1. Introduction 95 5.2. Prevention and crisis context 97 5.2.1. The breast cancer prevention in question: its system and players 98 5.3. Methodological choices for the analysis of an online exchange space 104 5.3.1. Boundaries of the field: study by the Facebook group “Cancer du sein, parlons-en” (Breast cancer, let’s talk about it) 104 5.3.2. Online non-participant observation 106 5.4. Results of ethnographic observation and lexicometric analysis 107 5.4.1. The emotional support registry 108 5.4.2. Informational input and tangible support 110 5.5. Conclusion 112 5.6. References 113 Part 3. Rethinking Health Expertise in Light of the Social Web 119 Chapter 6. The Expert Patient in the Digital Age: Between Myth and Reality 121Hélène ROMEYER 6.1. Introduction 121 6.2. Mutating health care: the professionalization of the patient 122 6.2.1. General framework 123 6.2.2. The slow evolution of the patient’s status and role 126 6.2.3. The evolution towards health information 128 6.3. Societal changes and the emergence of the expert patient in the digital context 132 6.3.1. New modalities of militancy 133 6.3.2. Technological change and empowerment 135 6.3.3. Therapeutic patient education: the unthought of digital culture and literacy 138 6.4. Conclusion 140 6.5. References 141 Chapter 7. Towards an Info-communication Categorization of Expertise in Online Health Communities 145Stéphane DJAHANCHAHI, Olivier GALIBERT and Benoit CORDELIER 7.1. Introduction 145 7.2. The crises of expertise in research in information and communication sciences 146 7.2.1. The question of expertise in the face of the diversity of forms of knowledge mobilized in socially relevant issues 147 7.2.2. The place of expertise in info-communication and community-based online knowledge mediation dispositives 149 7.3. Info-communicational theory of the online community link as a sociotechnical context for the deployment of online expertise 150 7.3.1. The ICS approach to health communities 152 7.3.2. Specificity of the terrain and the need for a new qualification of expertise 153 7.4. Info-communication approaches to health expertise 155 7.4.1. Expertise and the online health community 157 7.4.2. Negotiation as an info-communication process for legitimizing expertise 161 7.4.3. The legitimation of expertise or the production of a community consensus 161 7.5. Framework for the community validation of expertise 163 7.5.1. The three modes of legitimizing expertise in online health communities 164 7.5.2. Articulation of forms of expertise in the context of digital society 166 7.6. Conclusion 169 7.7. References 170 Chapter 8. Identification Metrics Regarding Lay Expertise in Online Health Communities 175Damien DE MEYERE 8.1. Introduction 175 8.2. Online health information and the notion of expertise 177 8.3. Data selection and presentation 178 8.4. Description of the measures 179 8.4.1. Characterizing engagement 179 8.4.2. Characterizing content 180 8.4.3. Characterizing the interaction 181 8.5. The multiple facets of lay expertise 182 8.6. Conclusion 190 8.7. Acknowledgments 191 8.8. References 191 List of Authors 195 Index 197

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Book SynopsisA comprehensive volume addressing the various approaches to designing and developing biocompatible coatings and the range of medical applications they offer.

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Book SynopsisWhen a patient is brought into a trauma centre in extremis, or becomes that way during a hospital stay, the intervention mantra is airway, breathing and circulation - the ABC's. This book provides the nonspecialist physician, and those in the participating and supporting professions, with a quick overview of the meaning of the testing terms in this environment. Many tests, added singly or in small groups over time as clinical and measurement technology evolved, but whose rationale may have become less clear, are defined and explained.The format here is simple - a brief overview of the physiologic environment and then the encyclopedic dictionary of the terminology. Included are common terms as well as some of the confusing uses of terms, besides lesser known facts influencing their clinical use on the basis of the analytical, medical, and managerial experience of the authors.

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Book SynopsisMicrobial applications encompass areas including biotechnology, chemical engineering, and alternative fuel development. Research on their technological developments cover many aspects of work using microbes as cell factories. The fields of biotechnology, chemical engineering, pharmaceuticals, diagnostics and medical device development also employ these microbial products. There is an urgent need to integrate all these disciplines that caters to the need of all those who are interested to work in the area of microbial technologies. This book is a step forward to integrate the aforesaid frontline branches into an interdisciplinary research work quenching the academic as well as research thirst of all those concerned about microbes in the respective area of biotechnology, chemical engineering, and pharmaceuticals. All the chapters in this book are related to important research on microbial applications, written by international specialists for researchers and academics in the concerned disciplines. This publication aims to provide a detailed compendium of experimental work and information used to investigate different aspects of microbial technologies, their products as well as interdisciplinary interactions including biochemistry of metabolites, in a manner that reflects the recent developments of relevance to researchers/scientists investigating microbes.

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Book SynopsisThe updated edition of the first of three volumes on Medical Physics focuses even more on body systems related to physical principles such as body mechanics, energy balance, and action potentials. Thanks to numerous newly incorporated didactic features, the introductory text into the broad fi eld of medical physics is easy to understand and supports self-study. New: highlighted boxes emphasize special topics; math boxes explain more advanced mathematical issues; each chapter concludes with a summary of the key concepts, questions, a self-assessment of the acquired competence, and exercises. The appendix contains answers to questions and solutions to exercises.

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Book SynopsisTo correctly diagnose a human organism with the help of acoustic waves is impossible without knowledge of the physics of acoustic waves interaction with the issues of the organism. This book is dedicated to the given problem. It consists of four sections, the first of which deals with physical models of the biological issues used in ultrasonic diagnostics. In the other sections the basic stages of ultrasonic diagnostics (sound radiation, sound scattering, depictions visualization) are studied. It is shown how different bodies and issues of a human organism scatter acoustic waves and how, using the scattered wave, one learns about what happens with some body or issue.Trade ReviewVery didactically organized, with ample attention for mathematical detail, which nowhere becomes so complicated that it obscures the physics behind it [...] The first three chapter give a thorough but accessible description of the physics of ultrasonic pulse-echo imaging, while the fourth discusses the possible methods to apply these data for 2D, 3D or time-dependent imagery [...] This book is a useful addition to the ultrasonic imaging literature, stepping into the - rather large - gap between more engineering-oriented texts and theoretical works. G. van Soest, PhD; Biomedical Engineering, Thorax center, Erasmus MC Rotterdam, the NetherlandsTable of ContentsINTRODUCTION Chapter 1. MODEL 1.1. Biological Tissue as a Homogeneous Continuum 1.2. Types of Biological Continua 1.3. Organism as a Heterogeneous Continuum 1.4. Equations of Motion of Biological Continua 1.5. Physical Nature of Ultrasonic Diagnostics Chapter 2. EMISSION 2.1. Unbounded Plane Emitter 2.2. Point Emitter (Monopole) 2.3. Bounded Plane Emitter 2.4. Point Emitter (Dipole) 2.5. Generation of Acoustic Oscillations Chapter 3. SCATTERING 3.1. Nature of a Scattered Wave 3.2. Immobile Large-Scale Inhomogeneities 3.3. Immobile Large-Scale Inhomogeneities with Boundary Layer 3.4. Immobile Small-Scale Inhomogeneities 3.5. Immobile Mesoscale Inhomogeneities 3.6. Mobile Inhomogeneities 3.7. Systems of Scatterers Chapter 4. VISUALIZATION 4.1. What Is Visualization? 4.2. Modes of Visualization 4.3. Defects of Acoustic Images AFTERWORD

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Book SynopsisThe study of manipulating materials on molecular as well as atomic scales is known as Nanotechnology. Nanotechnology deals with matters that are sized in between 1 to 100 nanometers. Nanotechnology is a new field of technology with science at nano levels. Materials behave differently at nano levels while their physical and chemical properties are unique at nano level. Nanotechnology can be applied in almost all the areas. The wide array of applications in nanotechnology has come to show one and all how much importance nanotechnology has in our lives today. Nanoscience and technology provides new ways and means to tackle critical issues and challenges in a very different manner for the benefit of mankind. This has to be understood by students, research scholars and scientists as well. The understanding of the nanomaterials and their properties are very essential for proper application in any field of science and technology. This book is written with an objective that students must understand the basic principles of nano science and technology for their further perspectives.

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Book SynopsisThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Trade Review"This outstanding volume represents a review of the various effects of biopharmaceuticals and nanomedicines on the immune system: immunotherapy, vaccines, and drug delivery; challenges and overcoming translational barriers stemming from immunotoxicity; strategies to designing more immunologically friendly formulations." —África González-Fernández, PhD, MD, Professor of Immunology and President of the Spanish Society of Immunology, University of Vigo, Spain "For those who are specialists, and for those interested in a broader understanding of biologics and nanomedicines, this is a superb book, with internationally accomplished contributors. It serves both as a reference and as a practical guide to the newest advances in these important fields. Highly recommended!"—Carl R. Alving, MD, Emeritus Senior Scientist, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA "A skillfully produced book that addresses an often-missed topic: immune aspects of biologicals and nanoscale therapeutics, with an emphasis on clinical relevance and applications." —Rajiv R. Mohan, PhD, Professor and Ruth M. Kraeuchi Missouri Endowed Chair Professor, University of Missouri, Columbia, USA"An indispensable masterpiece! It represents a rich source of information on interactions of biologics and nanodrugs with the immune system—all critical for medical applications. Volume 3, once again, achieves the series’ high standards."—László Rosivall, MD, PhD, DSc Med, Med habil., Széchenyi Prize Laureate and Professor, Faculty of Medicine, Semmelweis University, Budapest, Hungary "Hats off to Dr. Bawa for producing yet another impressive volume in terms of scope, timeliness, and relevance. With expert contributions from around the globe, this book addresses topics germane to researchers, clinicians, drug and biotherapeutic companies, regulators, policymakers, and patients." —Sara Brenner, MD, MPH, Associate Professor and Assistant Vice President, SUNY Polytechnic Institute, Albany, New York, USA"Marvelous! This timely book shows clearly that while an immune reaction to "nano-exposure" is usually unwanted, the same response also bears an immense potential." —Silke Krol, PhD, IRCCS Istituto Tumori "Giovanni Paolo II" and Fondazione IRCCS Istituto Neurologico "Carlo Besta," ItalyThe enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics. Table of ContentsList of Corresponding Authors, Foreword, My Life with Biologicals and Nanodrugs: A Twenty-Year Affair, 1. Current Immune Aspects of Biologics and Nanodrugs: An Overview, 2. Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox, 3. Immunotherapy and Vaccines, 4. Site-Specific Antibody Conjugation for ADC and Beyond, 5. Current Understanding of Interactions between Nanoparticles and the Immune System, 6. Auto-antibodies as Biomarkers for Disease Diagnosis, 7. The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers, 8. Anti-PEG Immunity Against PEGylated Therapeutics, 9. Complement Activation: Challenges to Nanomedicine Development, 10. Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation, 11. Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols, 12. Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions, 13. Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms, 14. Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities, 15. Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA, 16. Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism, 17. Immunogenicity Assessment for Therapeutic Protein Products, 18. Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products, 19. The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System, 20. Immunotherapy for Gliomas and Other Intracranial Malignancies, 21. Engineering Nanoparticles to Overcome Barriers to Immunotherapy, 22. Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications, 23. Silica Nanoparticles Effects on Hemostasis, 24. Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia, 25. Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin, 26. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines, 27. Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation, 28. Unwanted Immunogenicity: From Risk Assessment to Risk Management, 29. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials, 30. SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy, Index

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Book SynopsisNanomaterials have the potential to shift the paradigm for the diagnosis and treatment of many diseases, especially neoplasms, because of the intriguing behaviors associated with their unique size-/shape-influenced chemical, physical, and physiological features. Currently, there is a huge imbalance between the several nanoplatforms reported in the literature and the few ones approved for clinical applications. This disequilibrium affects, in particular, plasmonic nanomaterials, which present no approved platforms and few candidates in clinical trials. This trend can be reversed by promoting collaborations among scientists from different fields as well as by improving the multidisciplinary background of researchers interested in this area. This book is a collection of must-read peer-reviewed papers focusing on (i) the main behaviors of nanomaterials for nanomedicine, (ii) key features nanomaterials need for successful translation to the clinical setting, and (iii) market analysis of nanomaterials at the bedside or on the way. The main aim of this book is to offer a comprehensive point of view to students and researchers in order to promote the translation of new technologies to patients. It is a unique reference for advanced undergraduate- and graduate-level students of nanotechnology and researchers in materials science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in cancer theranostics.Table of ContentsDetecting and Destroying Cancer Cells in More Than One Way with Noble Metals and Different Confinement Properties on the Nanoscale. Engineered Nanoparticles for Drug Delivery in Cancer Therapy. Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles. Gold Nanomaterials at Work in Biomedicine. The Nanomedicines Alliance: An Industry Perspective on Nanomedicines. Nanomedicine(s) under the Microscope. Imaging Nano–Bio Interactions in the Kidney: Toward a Better Understanding of Nanoparticle Clearance. Nanomaterials for Theranostics: Recent Advances and Future Challenges. Metabolism of Nanomaterials in vivo: Blood Circulation and Organ Clearance.

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Book SynopsisFeatures a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields With a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear partial differential equations. The author's primary focus is on models expressed as systems of PDEs, which generally result from including spatial effects so that the PDE dependent variables are functions of both space and time, unlike ordinary differential equaTable of ContentsPreface ix 1. Introduction to Partial Differentiation Equation Analysis: Chemotaxis 1 2. Pattern Formation 43 3. Belousov–Zhabotinskii Reaction System 103 4. Hodgkin–Huxley and Fitzhugh–Nagumo Models 127 5. Anesthesia Spatiotemporal Distribution 163 6. Influenza with Vaccination and Diffusion 207 7. Drug Release Tracking 243 8. Temperature Distributions in Cryosurgery 287 Index 323

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Book SynopsisThe tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.Table of ContentsTissue Engineering Models for Cancer Pathology;Introduction to the Tumor Microenvironment;Mimicking Fibrous Topographical Features of the Tumor Microenvironment;Mimicking Mechanical Features of the Tumor Microenvironment;Mimicking Chemical Features of the Tumor Microenvironment;Mimicking Multicellular Features of the Tumour Microenvironment;Cell Patterning to Mimic Tumor Anatomy;Advanced Scaffold Design via Electrospinning;Advanced Scaffold Fabrication using Additive Manufacturing;Microfluidic Models of the Tumour Microenvironment;Modeling of the Tumor Microenvironment in Tumor Organoids;Imaging in Scaffolds;The Intersection of Biomaterials,Tissue Engineering and Immuno-oncology;Tissue Engineered Models of Metastasis: Focus on Bone Metastasis;Tissue-engineered Cancer Models in Drug Screening

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Table of ContentsPart 1. Structure and properties of orthodontic biomaterials 1. Structure/property relationships in orthodontic alloys 2. Structure/property relationships in orthodontic polymers 3. Structure/property relationships in orthodontic ceramics Part 2. Orthodontic alloys: properties and clinical effects 4. Orthodontic brackets 5. In vitro friction assessment in orthodontics 6. Nickel-titanium products in daily orthodontic practice 7. Material properties and effects on mechanotherapy 8. Adverse effects from orthodontic alloys Part 3. Bonding to enamel with orthodontic adhesives 9. Composite resin polymerization and relevant parameters 10. Frequent handling mistakes during bonding 11. Bond strength and its limited role in assessing efficacy 12. Clinical evidence of bond failure and associated factors 13. Bisphenol A and orthodontic materials 14. Enamel alterations due to orthodontic treatment 15. Bonding of fixed lingual retainers in orthodontics 16. Bonding with glass-ionomer cements and resin-modified glass ionomer cements 17. Future of bonding Part 4. Orthodontic aligners 18. Aligners for orthodontic applications

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Table of Contents1. Introduction2. Mathematical preliminaries3. Recurrent high order neural network identification of nonlinear discrete-time unknown system with time-delays4. Neural identifier-control scheme for nonlinear discrete-time unknown system with time-delays5. Recurrent high order neural network observer of nonlinear discrete-time unknown systems with time-delays6. Neural observer-control scheme for nonlinear discrete-time unknown system with time-delays7. Concluding remarks and future trends AppendixA. Artificial neural networksB. Linear induction motor prototypeC. Differential robot prototype

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Book SynopsisThis text covers not only the theory of operation, fundamentals and history of inductively coupled plasma-mass spectrometry (ICP-MS) but includes information which allows the reader to choose the equipment configurations which are best suited to their particular operation.Table of ContentsFundamentals and history of ICP-MS; instrumentation; other types of plasma ion sources for mass spectrometry; spray chambers, nebulisers and torches; sample preparation; sample introduction techniques; interferences; trace element analysis (silicates, carbonates, etc); ultra-trace element analysis (REE and PGE); isotope ratio measurements. Appendices: mass tables, ionisation potentials, predicted.

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Book SynopsisProgrammable Planet is a grand tour through the world of synthetic biology, telling the stories of the colorful visionaries whose ideas are shaping discoveries. Ted Anton explores the field from its beginning in fighting malaria in Africa to the COVID vaccines and beyond.Trade ReviewProgrammable Planet captures the passion and energy of those at the genesis of the construction of the genetically engineered world. -- Christopher Voigt, Daniel I.C. Wang Professor of Biological Engineering, Massachusetts Institute of TechnologyIf you’ve ever wondered about the promise—and the peril—of synthetic biology and its power to transform life, then Programmable Planet is the book for you. Ted Anton’s exploration of both the history and the future of the ways we engineer life is incisive, engaging, and downright fascinating. -- Deborah Blum, Pulitzer Prize–winning author of The Poison Squad: One Chemist’s Single-Minded Crusade for Food Safety in the Early Twentieth CenturyProgrammable Planet is a thoroughly engaging and enjoyable read. Anton is an expert storyteller who blends the human element with cutting-edge science like a synthetic biologist engineering a novel organism. Timely and at times provocative, the book provides a wonderful grounding for those interested in learning more about synthetic biology’s promise and threat. And we should all be interested in learning more. -- Aoife Brennan, president and chief executive officer, SynlogicIn this rollicking compendium, Anton documents a huge number of ways synthetic biology can be used in practice, embedding these examples in the experiences of the people involved. -- Drew Endy, Stanford UniversityTable of ContentsIntroductionPart I. Beginnings1. A Glass of Absinthe: A Malaria Medicine2. A Radical Philosophy3. Pandora’s Box: The Triumph and Temptation of Gene Editing4. The Silk Road: Directing Evolution5. Wild: Remaking LifePart II. Ripples in the Water6. Rush: Biology-Made Medicines7. New Nature: A Do-It-Yourself Environment8. Hearth and Home9. Fantastic Voyages: Mining and the Military10. The Killers: Viruses as HealersPart III. Bioindustrial Revolution11. Race to a Vaccine12. Global Production: Perils and Profits of a New Science13. The Moirai’s Gift14. To the Planets, and Beyond: Synthetic Biology in Space15. FuturamaAcknowledgmentsTimelineGlossaryFurther ReadingNotesIndex

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Book SynopsisFor this ground-breaking book, Philip Pugh has assembled a team of contributors who show just how much solar observation work can be accomplished with Coronado telescopes, and explain how to get the best from these marvelous instruments.Trade ReviewFrom the reviews: "Observing the Sun is becoming more and more popular these days … . there’s a whole range of Coronado solar telescopes on offer. This book aims to clarify the differences between them and give you solid advice on what each one can do. … The chapters are well written and comprehensive. … this is actually a very useful resource if you’re interested in pursuing solar observing or imaging – not just if you have a scope made by Coronado in your garage. … it’s highly recommended." (Pete Lawrence, BBC Sky at Night, April, 2008) "Philip Pugh’s new book, which includes contributions from several expert coauthors, covers more ground than its title suggests – including gear from other manufacturers. … I think it serves as a valuable reference and a worthwhile review of the current state of the art of daytime amateur astronomy." (Rick Fienberg, Sky and Telescope, July, 2008) "This book does exactly what it says on the cover and more. It covers the whole gambit of solar observation in both red hydrogen light (hydrogen-alpha) and violet calcium light (CaK) and is profusely illustrated with telescopes, accessories and innumerable solar images. … The text is upbeat … . this is an excellent book and essential reading for all interested in this fascinating area of observation – no less in that it occurs at sociable daylight hours!" (Maurice Gavin, Astronomy Now, June, 2008) "This book provides a wealth of useful information on choosing the right telescope, what accessories work best with those instruments, the use of cameras and CCD detectors, and the post-processing of their images. There are copious illustrations of both the instrumentation and the results … . I have no hesitation in recommending this book. For potential buyers of such telescopes this book is well worth … . Philip Pugh and his co-authors are to be congratulated on a very useful guide." (Steve Bell, The Observatory, Vol. 128 (1206), October, 2008) "This book aims to review the options available as well as briefly covering equipment from other sources. … I would be very happy to recommend this book to anyone who is considering the purchase of equipment to image our Sun in narrow-band hydrogen-alpha light. It does a good job of reviewing the options available and the best photographs really do show the amazing images that can be seen visually and recorded for later enhancement using a variety of image processing techniques and software." (Peter R. Hobson, Contemporary Physics, Vol. 50 (5), September-October, 2009)Table of ContentsPersonal Solar Telescope.- MaxScope 90.- Other Coronado Solar Telescopes.- Imaging.- Alternative Products.- Untried Products.- Summary.- The Physics of the Sun.- Coronado Price List.

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Book SynopsisHumans have always been fascinated by marine life, from extremely small diatoms to the largest mammal that inhabits our planet, the blue whale.Trade ReviewFrom the reviews:“Provides a comprehensive overview of the bioacoustics of marine life. It is targeted for bioacousticians, and is intended to focus on areas of knowledge that they should master. … This book achieves its objective of providing that knowledge base. It also is a valuable information source for engineers and scientists with a background in acoustics, and who are interested in gaining insights into the bioacoustics of marine life. … a valuable information source on marine bioacoustics and is recommended.” (Martin L. Pollack, Noise Control Engineering Journal, Vol. 58 (6), November-December, 2010)“The book incorporates detailed qualitative and quantitative information and analysis of the sounds produced by marine life with a particular emphasis on marine mammals. … the book contains a vast amount of useful information supported by extensive experimental evidence. … The descriptions of experimental design, measurement, and analysis techniques make this a good starting point for someone planning further experiments in this domain. … I recommend this book to anyone searching for knowledge of marine bioacoustics.” (Adrian Brown, International Journal of Acoustics and Vibration, Vol. 16 (2), 2011)Table of ContentsPrinciples and Methodology.- Measurement and Generation of Underwater Sounds.- Transducer Properties and Utilization.- Acoustic Propagation.- Signal Recording and Data Acquisition.- Fourier Analysis.- Auditory Systems of Marine Animals.- Experimental Psychological and Electrophysiological Methodology.- Acoustics of Marine Animals.- Hearing in Marine Animals.- Emission of Social Sounds by Marine Animals.- Echolocation in Marine Mammals.- Some Signal Processing Techniques.- Some Instrumentation for Marine Bioacoustics Research.

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Book SynopsisThe author, a physiologist, in giving the Liversidge lecture for 'the encouragement of research in chemistry', chose for his subject one in which the help of chemists as well as engineers and physicists is an essential condition of advance. It is his earnest hope that as a result of this book a chemist may come to the aid of physiologists in one of the most difficult and attractive scientific problems; the nature of the change that is transmitted in nerve.Table of ContentsPreface; 1. Chemical Wave Transmission in Nerve; 2. Appendix 1. The excitation of nerve; 3. Appendix 2. The measurement of the heat production of nerve; 4. Appendix 3. The energy of a nerve stimulus; References; Index.

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Book SynopsisOrganised around problem solving, this book introduces the reader to computational simulation of biomedical transport processes, bridging fundamental theory with real-world applications. Step-by-step instructions enable a newcomer to get started immediately and the inclusion of property data and case studies provide usable models that can be applied further afield.Table of ContentsPart I. Essential Steps: 1. Problem formulation; 2. Software implementation: what to solve; 3. Software implementation: how to solve (preprocessing); 4. Software implementation: visualizing and manipulating solution (postprocessing); 5. Validation, sensitivity analysis, optimization and debugging; Part II. Case Studies: 6. Case studies; Part III. Background Material: 7. Governing equations and boundary conditions; 8. Source terms; 9. Material properties and other input parameters; 10. Solving the equations: numerical methods.

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Book SynopsisSulphate-reducing bacteria play an important role in many biogeochemical processes. This timely update on research, from the basic biochemical mechanisms of these microorganisms to their environmental roles, will be a valuable resource for researchers in the fields of microbial ecology and physiology, bioengineering, biogeochemistry and related areas of environmental science.Trade ReviewReview of the hardback: 'It is an essential reference for microbiologists and global ecosystem researchers, and is recommended as a priority purchase for libraries, and by individuals whose work relates to SRB. The quality of the science and presentation is excellent, and a joy to read.' Ann Wood, King's College LondonTable of ContentsPreface; 1. Energy metabolism and phylogenetic diversity of sulphate-reducing bacteria Rudolf K. Thauer, Erko Stackebrandt and W. Allan Hamilton; 2. Molecular strategies for studies of natural populations of sulphate-reducing micro-organisms David A. Stahl, Alexander Loy and Michael Wagner; 3. Functional genomics of sulphate-reducing prokaryotes Ralf Rabus and Axel Strittmatter; 4. Evaluation of stress response in sulphate-reducing bacteria through genome analysis J. D. Wall, H. C. Bill Yen, and E. C. Drury; 5. Response of sulphate-reducing bacteria to oxygen Henrik Sass and Heribert Cypionka; 6. Biochemical, proteomic and genetic characterisation of oxygen survival mechanisms in sulphate-reducing bacteria of the genus Desulfovibrio Alain Dolla, Donald M. Kurtz, Jr., Miguel Teixeira and Gerrit Voordouw; 7. Biochemical, genetic and genomic characterisation of anaerobic electron transport pathways in sulphate-reducing delta-proteobacteria Inês A. C. Pereira, Shelley A. Haveman and Gerrit Voordouw; 8. Dissimilatory nitrate and nitrite ammonification by sulphate-reducing eubacteria José J. G. Moura, Pablo Gonzalez, Isabel Moura and Guy Fauque; 9. Anaerobic degradation of hydrocarbons with sulphate as electron acceptor Friedrich Widdel, Florin Musat, Katrin Knittel and Alexander Galushko; 10. Sulphate-reducing bacteria from oil field environments and deep-sea hydrothermal vents Bernard Ollivier, Jean-Luc Cayol and Guy Fauque; 11. The sub-seafloor biosphere and sulphate-reducing prokaryotes: their presence and significance R. John Parkes and Henrik Sass; 12. Eco-physiology of sulphate-reducing bacteria in environmental biofilms Satoshi Okabe; 13. Bioprocess engineering of sulphate reduction for environmental technology Piet N. L. Lens, Marcus Vallero and Giovanni Esposito; 14. Bioremediation of metals and metalloids by precipitation and cellular binding Simon L. Hockin and Geoffrey M. Gadd; 15. Enzymatic and genomic studies on the reduction of mercury and selected metallic oxy-anions by sulphate-reducing bacteria Mireille Bruschi, Larry L. Barton, Florence Goulhen, and Richard M. Plunkett; 16. Sulphate-reducing bacteria and their role in corrosion of ferrous materials Iwona B. Beech and Jan A. Sunner; 17. Anaerobic metabolism of nitroaromatic compounds and bioremediation of explosive by sulphate-reducing bacteria Raj Boopathy; 18. Sulphate-reducing bacteria and the human large intestine George T. Macfarlane, John H. Cummings and Sandra Macfarlan.

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Book SynopsisThis book, first published in 2002, introduces methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways and discusses the design and analysis of systems models. All concepts are derived from first principles and the well-illustrated text is accompanied by two detailed case studies.Table of ContentsPreface; 1. Target: a useful model; 2. Methods of biochemical systems theory; 3. A model of citric acid production in the mold Aspergillus niger; 4. Optimization methods; 5. Optimization of biochemical systems; 6. Optimization of citric acid production in Aspergillus niger; 7. Maximization of ethanol and carbohydrate production in Saccharomyces cerevisiae; 8. Conclusions; Author index; Subject index.

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Book SynopsisWith mathematical and computational models furthering our understanding of lung mechanics, function and disease, this book provides an all-inclusive introduction to the topic from a quantitative standpoint. Focusing on inverse modeling, the reader is guided through the theory in a logical progression, from the simplest models up to state-of-the-art models that are both dynamic and nonlinear. Key tools used in biomedical engineering research, such as regression theory, linear and nonlinear systems theory, and the Fourier transform, are explained. Derivations of important physical principles, such as the Poiseuille equation and the wave speed equation, from first principles are also provided. Example applications to experimental data throughout illustrate physiological relevance, whilst problem sets at the end of each chapter provide practice and test reader comprehension. This book is ideal for biomedical engineering and biophysics graduate students and researchers wishing to understandTrade Review'In a clearly written language, Jason Bates provides a grand tour into the frontiers of the bioengineering of lung mechanics and physiology. The reader is elegantly led through the intricacy and beauty of forward and inverse modeling applied to the lung with plenty of examples for the physiologist, problems for the teacher, insight for the scientist and even some food for the philosophically oriented.' Bela Suki, Boston University'This book aims to provide physiologists and medical professionals interested in lung mechanics an understanding of the mathematics behind modeling. In my view, Jason Bates has succeeded. While the depth of the mathematics may be daunting, the explanations are clear and Jason takes the readers by the hand and leads them gently through the maze, arriving on the other side enlightened! No where is this more obvious than I the chapter on the derivation of the constant phase model and hysteresivity. These have become family names to modern respiratory physiologists; however, I would venture that the majority who use them do not understand them. Reading Jason's book allows a much greater understanding of these and other common concepts in modeling the mechanical behaviour of the lungs. I recommend this to all currently in the field and those wanting to enter. Well done!' Peter Sly, Telethon Institute for Child Health Research'In a clearly written language, Jason Bates provides a grand tour into the frontiers of the bioengineering of lung mechanics and physiology. The reader is elegantly lead through the intricacy and beauty of forward and inverse modeling applied to the lung with plenty of examples for the physiologist, problems for the teacher, insight for the scientist and even some food for the philosophically oriented.' Bela Suki, Boston University'This is a very well-written book which fulfills a major need for a thorough and quantitative analysis of respiratory mechanics. Moreover, Dr Bates does a superb job at simplifying rigorous applied mathematical theory such that practicing clinicians and life scientists with little to no mathematical training can be proficient in concepts that have traditionally been the domain of graduate-level engineers and physicists.' David W. Kaczka, Johns Hopkins University'This long-needed textbook identifies and then bridges the gap between the classical views on lung mechanics and the experimental evidence; an enormous help for students and a valuable teaching resource for lecturers and senior researchers.' Zoltán Hantos, University of Szeged, HungaryTable of ContentsPreface; Notation; 1. Introduction; 2. Collecting data; 3. The linear single-compartment model; 4. Resistance and elastance; 5. Nonlinear single-compartment models; 6. Flow limitation; 7. Linear two-compartment models; 8. The general linear model; 9. Inverse models of lung impedance; 10. Constant phase model of impedance; 11. Nonlinear dynamic models; 12. Epilogue; References; Index.

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Book SynopsisThis book is written for the non-engineer involved in computerized data acquisition. It is an indispensable guide to setting up these systems and obtaining useful information from them. Aimed at life sciences researchers, it will also be valuable to anyone interested in learning to use data acquisition systems. Illustrations and worked examples accompany the text.Trade Review'… technically informative, jargon free and truly educational.' P. Cunningham, Cell Biochemistry and FunctionTable of ContentsPreface; 1. The bare essentials; 2. How a data acquisition system works; 3. Important concepts; 4. Connecting to the real world with transducers; 5. Data manipulation; 6. Examples; Appendix; Notes; References; Index.

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Book SynopsisThis book is written for the non-engineer involved in computerized data acquisition. It is an indispensable guide to setting up these systems and obtaining useful information from them. Aimed at life sciences researchers, it will also be valuable to anyone interested in learning to use data acquisition systems. Illustrations and worked examples accompany the text.Trade Review'… technically informative, jargon free and truly educational.' P. Cunningham, Cell Biochemistry and FunctionTable of ContentsPreface; 1. The bare essentials; 2. How a data acquisition system works; 3. Important concepts; 4. Connecting to the real world with transducers; 5. Data manipulation; 6. Examples; Appendix; Notes; References; Index.

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Book SynopsisThis book addresses the role of mechanical factors in the development, adaptation, maintenance, ageing, and repair of skeletal tissues such as bones, cartilage, tendons, ligaments and muscles. The authors show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age.Trade Review'… readers with an interest in skeletal form and function will gain new understanding of the possible roles of physical forces in skeletal tissue processes … and will be drawn to wonder about the physical, biological, and evolutionary mechanisms responsive for skeletal tissue function and form.' Richard T. Hart, Journal of Biomechanics'… this book is a comprehensive synopsis of the mechanobiology of the skeleton extended and updated with many rigorous analytical models …' David Green, The Times Higher Education Supplement'This excellent book is a comprehensive introduction to the study of the modulation of bone form and function by mechanical stimuli. This is an informative and enjoyable book … A recommended read for graduate studies in biology and orthopaedics as well as for practising orthopaedic surgeons.' David Green, The Times Higher Education Supplement'As a vertebrate palaeobiologist interested in animal design and function from a number of perspectives I was interested to read this book. Overall it is a masterly treatment of the subject … has its place on library shelves and in the offices of genuine specialists.' Journal of the Geological Magazine'… there is much that is interesting and thought-provoking in the book.' International Journal of OsteoarchaeologyTable of ContentsPreface; 1. Form and function; 2. Skeletal tissue histomorphology and mechanics; 3. Cartilage differentiation and growth; 4. Perichondral and periosteal ossification; 5. Endochondral growth and ossification; 6. Cancellous bone; 7. Skeletal tissue regeneration; 8. Articular cartilage development and destruction; 9. Mechanobiology in skeletal evolution; 10. The physical nature of living things; Appendix A. Material characteristics; Appendix B. Structural characteristics; Appendix C. Failure characteristics; Index.

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Book SynopsisRevolutionary advances in imaging technology that provide high resolution, 3-D, non-invasive imaging of biological subjects have made biomedical imaging an essential tool in clinical medicine and biomedical research. Key technological advances include MRI, positron emission tomography (PET) and multidetector X-ray CT scanners. Common to all contemporary imaging modalities is the creation of digital data and pictures. The evolution from analog to digital image data is driving the rapidly expanding field of digital image analysis. Scientists from numerous disciplines now require in-depth knowledge of these complex imaging modalities. Introduction to the Science of Medical Imaging presents scientific imaging principles, introduces the major biomedical imaging modalities, reviews the basics of human and computer image analysis and provides examples of major clinical and research applications. Written by one of the world's most innovative and highly respected neuroradiologists, IntroductionTrade Review'This reviewer knows of no other source in medical imaging science that lays out the whole field so interestingly and with new twists in conveying information. It is a highly recommended purchase either for an individual or a department.' American Journal of Neuroradiology'Very well written … Excellent images and diagrams … concise and up to date … a landmark text on the science of image interpretation. The authors manage to make a very complex subject very readable … relevant figures are exceptional …' BMA Medical Book Awards reviewer'This is a most unusual and fascinating book. It blends science, philosophy and practical imaging in a very unusual way … As somebody closely involved in imaging I found it a fascinating read.' European RadiologyTable of ContentsPreface; Part I. Introduction: 1. What is an image?; 2. How to make an image; 3. How to analyze an image; Part II. Biomedical Images: 4. Nuclear medicine; 5. X-ray: non-ionizing radiation; 6. Ultrasound; 7. Magnetic resonance imaging; 8. Optical imaging; Part III. Sample Labeling: 9. Contrast agents; 10. Molecular labeling; Part IV. Image Analysis: 11. Human observer; 12. Digital image processing; 13. Registration and atlas building; 14. Statistical atlases; Part V. Biomedical Applications: 15. Morphological imaging; 16. Physiological imaging; 17. Molecular imaging; Appendices: 1. Linear systems; 2. Transforms and k space; 3. Probability, Bayesian statistics and information theory; Index.

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Book SynopsisOffering a consistent, systematic approach to capacitive, piezoelectric and magnetic MEMS, from basic electromechanical transducers to high-level models for sensors and actuators, this comprehensive textbook equips graduate and senior-level undergraduate students with all the resources necessary to design and develop practical, system-level MEMS models. The concise yet thorough treatment of the underlying principles of electromechanical transduction provides a solid theoretical framework for this development, with each new topic related back to the core concepts. Repeated references to the shared commonalities of all MEMS encourage students to develop a systems-based design perspective. Extensive use is made of easy-to-interpret electrical and mechanical analogs, such as electrical circuits, electromechanical two-port models and the cascade paradigm. Each chapter features worked examples and numerous problems, all designed to test and extend students'' understanding of the key principlTrade Review'This is an excellent textbook presenting the fundamentals of electromechanics required by every practising MEMS engineer. The authors treat the arduous concepts of coupled electrical and mechanical systems simultaneously with lucidity and a thorough pedagogical rigor that comes from deep appreciation of the field and the love to impart that knowledge as a teacher. The book elucidates the concepts with very topical examples of microelectromechanical systems such as MEMS microphones, comb drive actuators, gyroscopes, energy harvesters, and piezoelectric and magnetic devices including Matlab® models and [a] comprehensive set of problems at the end of each chapter.' Srinivas Tadigadapa, Pennsylvania State University'A fantastic book for the student seeking a solid foundation in electromechanical device design and an essential reference for the expert MEMS engineer. Jones and Nenadic present the fundamental theory behind electromechanical transduction, with a focus on capacitive drive and sense microsystems. The authors systematically frame the device fundamentals into real world micro scale device applications that provide relevance to the underlying physics. This book captures and dutifully explains the foundational physics at work in the MEMS devices we often unknowingly use daily in our automobiles, mobile phones and electronic devices.' Chris Keimel, GE Global Research'Electromechanics and MEMS is a thorough treatment of fundamental MEMS analysis for both the student and the practitioner. The readers are presented with the tools to methodically build system models that are comprehensive yet manageable.' Eric Chojnacki, MEMSIC, Inc.'Having designed and built MEMS for many years, I have come to appreciate a clear well-written book on the subject. The treatment by Jones and Nenadic is excellent. MEMS is a field of many specialties requiring knowledge of fabrication, electrostatics, mechanics, noise and circuits. The authors provide broad coverage of these topics, and thus allow students to understand how these systems fit together. The details on electrostatics and mechanics are rich and there are numerous examples which motivate these topics. The writing style is clear and approachable; light-hearted when possible and diligent when necessary. Ultimately, the text serves to sufficiently train the reader in the design trade-offs inherent in MEMS design. I am glad to see this new text and expect it to be a valuable resource for years to come.' Kevin A. Shaw, Sensor Platforms, Inc.Table of Contents1. Introduction; 2. Circuit-based modeling; 3. Capacitive lumped parameter electromechanics; 4. Small-signal capacitive electromechanical systems; 5. Capacitive sensing and resonant drive circuits; 6. Distributed 1-D and 2-D electromechanical structures; 7. Practical MEMS devices; 8. Electromechanics of piezoelectric elements; 9. Electromechanics of magnetic MEMS devices; A. Review of quasistatic electromagnetics; B. Review of mechanical resonators; C. Micromachining; D. A brief review of solid mechanics.

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Book SynopsisProviding a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.Trade Review'We live in transformative times and perhaps big data and analytics represent a most interesting and essential concept of today. From the telescope to the microscope, our ability to peer into complexities of life has transformed humanity. Big data is the next major step in major transition. Bioinformatics and Computational Biology in Drug Discovery and Development is a road map to an inevitable future - a future where data define disease, diagnosis and drugs. This book is an essential companion for anyone in drug development who has one foot in the present and one in the future.' John Nosta, President, NOSTALABTable of ContentsForeword; Preface: the future of drug discovery and health care Eric Schadt; 1. The art and science of the Drug Discovery Pipeline (DDP) William T. Loging; 2. Computational approaches to drug target identification Thomas B. Freeman and Pek Lum; 3. Understanding human disease knowledge through text mining Raul Rodriguez-Esteban; 4. Integrating translational biomarkers into drug development Jonathan Phillips; 5. Computational phenotypic assessment of small molecules in drug discovery William T. Loging and Thomas B. Freeman; 6. Data visualization and the DDP process Ke Xu; 7. Information visualization – important IT considerations Telmo Silva; 8. The New Drug Application (NDA) and regulatory approval stages William T. Loging, Marilyn Lewis, Bryn Williams-Jones and Roy Mansfield; 9. Clinical trial failures and drug repositioning Mark Crawford and Jeff Handler; Appendix I. Additional knowledge-based analysis approaches Raul Rodriguez-Esteban; Appendix II. Open source tools and public data sources Yirong Wang and William T. Loging; Index.

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Book SynopsisA hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. Practical examples are given throughout, representing real-world case studies of key application areas, and all data and complete codes for simulation and data analysis are provided online.Trade Review"concise, very readable textbook..overall, this is a nicely written text that focuses on the more practical aspect of biosimulation, and avoids bogging down the reader with esoteric mathematical theorems and proofs. Recommended." - M.R. King, CHOICE, December 2012"...this publication does justice to its central aim of providing practical guidance in the development of mathematical models of biological systems. It would likely serve well as a textbook for a course addressing the main subject areas, and as a reference for researchers working in those areas who wish to build such models or better understand their construction." - Christopher R. Myers, Cornell University, Quarterly Review of Biology, June 2013Table of Contents1. Introduction to simulation of biological systems; 2. Transport and reaction of solutes in biological systems; 3. Physiologically-based pharmacokinetic modeling; 4. Cardiovascular systems simulation; 5. Chemical reaction systems: thermodynamics; 6. Chemical reaction systems: kinetics; 7. Chemical reaction systems: large-scale systems simulation; 8. Cellular electrophysiology; 9. Appendices: mathematical and computational techniques.

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Book SynopsisThe intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order. This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, ageing and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for underTrade Review'… readers with an interest in skeletal form and function will gain new understanding of the possible roles of physical forces in skeletal tissue processes … and will be drawn to wonder about the physical, biological, and evolutionary mechanisms responsive for skeletal tissue function and form.' Richard T. Hart, Journal of Biomechanics'… this book is a comprehensive synopsis of the mechanobiology of the skeleton extended and updated with many rigorous analytical models …' David Green, The Times Higher Education Supplement'This excellent book is a comprehensive introduction to the study of the modulation of bone form and function by mechanical stimuli. This is an informative and enjoyable book … A recommended read for graduate studies in biology and orthopaedics as well as for practising orthopaedic surgeons.' David Green, The Times Higher Education Supplement'As a vertebrate palaeobiologist interested in animal design and function from a number of perspectives I was interested to read this book. Overall it is a masterly treatment of the subject … has its place on library shelves and in the offices of genuine specialists.' Journal of the Geological Magazine'… there is much that is interesting and thought-provoking in the book.' International Journal of OsteoarchaeologyTable of ContentsPreface; 1. Form and function; 2. Skeletal tissue histomorphology and mechanics; 3. Cartilage differentiation and growth; 4. Perichondral and periosteal ossification; 5. Endochondral growth and ossification; 6. Cancellous bone; 7. Skeletal tissue regeneration; 8. Articular cartilage development and destruction; 9. Mechanobiology in skeletal evolution; 10. The physical nature of living things; Appendix A. Material characteristics; Appendix B. Structural characteristics; Appendix C. Failure characteristics; Index.

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Book SynopsisSulphate-reducing bacteria play an important role in many biogeochemical processes. This timely update on research, from the basic biochemical mechanisms of these microorganisms to their environmental roles, will be a valuable resource for researchers in the fields of microbial ecology and physiology, bioengineering, biogeochemistry and related areas of environmental science.Trade ReviewReview of the hardback: 'It is an essential reference for microbiologists and global ecosystem researchers, and is recommended as a priority purchase for libraries, and by individuals whose work relates to SRB. The quality of the science and presentation is excellent, and a joy to read.' Ann Wood, King's College LondonTable of ContentsPreface; 1. Energy metabolism and phylogenetic diversity of sulphate-reducing bacteria Rudolf K. Thauer, Erko Stackebrandt and W. Allan Hamilton; 2. Molecular strategies for studies of natural populations of sulphate-reducing micro-organisms David A. Stahl, Alexander Loy and Michael Wagner; 3. Functional genomics of sulphate-reducing prokaryotes Ralf Rabus and Axel Strittmatter; 4. Evaluation of stress response in sulphate-reducing bacteria through genome analysis J. D. Wall, H. C. Bill Yen, and E. C. Drury; 5. Response of sulphate-reducing bacteria to oxygen Henrik Sass and Heribert Cypionka; 6. Biochemical, proteomic and genetic characterisation of oxygen survival mechanisms in sulphate-reducing bacteria of the genus Desulfovibrio Alain Dolla, Donald M. Kurtz, Jr., Miguel Teixeira and Gerrit Voordouw; 7. Biochemical, genetic and genomic characterisation of anaerobic electron transport pathways in sulphate-reducing delta-proteobacteria Inês A. C. Pereira, Shelley A. Haveman and Gerrit Voordouw; 8. Dissimilatory nitrate and nitrite ammonification by sulphate-reducing eubacteria José J. G. Moura, Pablo Gonzalez, Isabel Moura and Guy Fauque; 9. Anaerobic degradation of hydrocarbons with sulphate as electron acceptor Friedrich Widdel, Florin Musat, Katrin Knittel and Alexander Galushko; 10. Sulphate-reducing bacteria from oil field environments and deep-sea hydrothermal vents Bernard Ollivier, Jean-Luc Cayol and Guy Fauque; 11. The sub-seafloor biosphere and sulphate-reducing prokaryotes: their presence and significance R. John Parkes and Henrik Sass; 12. Eco-physiology of sulphate-reducing bacteria in environmental biofilms Satoshi Okabe; 13. Bioprocess engineering of sulphate reduction for environmental technology Piet N. L. Lens, Marcus Vallero and Giovanni Esposito; 14. Bioremediation of metals and metalloids by precipitation and cellular binding Simon L. Hockin and Geoffrey M. Gadd; 15. Enzymatic and genomic studies on the reduction of mercury and selected metallic oxy-anions by sulphate-reducing bacteria Mireille Bruschi, Larry L. Barton, Florence Goulhen, and Richard M. Plunkett; 16. Sulphate-reducing bacteria and their role in corrosion of ferrous materials Iwona B. Beech and Jan A. Sunner; 17. Anaerobic metabolism of nitroaromatic compounds and bioremediation of explosive by sulphate-reducing bacteria Raj Boopathy; 18. Sulphate-reducing bacteria and the human large intestine George T. Macfarlane, John H. Cummings and Sandra Macfarlan.

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Book SynopsisElectrokinetics is currently the mechanism of choice for fluid actuation and bioparticle manipulation at microscale and nanoscale dimensions. There has recently been interest in the use of AC electric fields, given the many advantages it offers over DC electrokinetics. Nevertheless, a fundamental understanding of the governing mechanisms underlying the complex and nonlinear physicochemical hydrodynamics associated with these systems is required before practical microfluidic and nanofluidic devices can be engineered. This text aims to provide a comprehensive treatise on both classical equilibrium electrokinetic phenomena as well as the more recent non-equilibrium phenomena associated with both DC and AC electrokinetics in the context of their application to the design of microfluidic and nanofluidic technology. In particular, Leslie Yeo and Hsueh-Chia Chang discuss the linear and nonlinear theories underlying electroosmosis, electrophoresis, and dielectrophoresis pertaining to electrolyTable of Contents1. Introduction and fundamental concepts; 2. Classical equilibrium theory due to surface changes; 3. Electroosmotic transport; 4. Electrophoretic transport and separation; 5. Field-induced dielectric polarization; 6. DC nonlinear electrokinetics due to field-induced double layer polarization; 8. Dielectrophoresis and electrorotation - double layer effects; 9. Electrohydrodynamic atomization, electrospinning and discharge driven vortices.

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Book SynopsisA concise introduction to the physics of charged macromolecules, from the basics of electrostatics to cutting-edge modern research developments. Providing a clear and intuitive view of concepts and theory, this accessible book also discusses results from real-world experiments and simulations. A perfect guide for students entering the field.Trade Review'Understanding the behavior of charged macromolecules in solution is one of the grand challenges of modern soft matter physics and chemistry, as these phenomena impact a multitude of cellular processes as well as numerous emerging technologies. This monograph, by a world expert in the field, is unique in providing a self-contained tutorial approach that begins with the basic of electrostatics, polymer conformations, and solution thermodynamics, and proceeds to cover self-assembly, phase separation and coacervation, dynamics, and polyelectrolyte gels. The level is tailored to beginning graduate students, and the author's style gently captures the mathematical sophistication required, while never losing sight of the underlying physics. This book represents the first comprehensive pedagogical overview of the field, and even experts can learn much from its treatment.' Tim Lodge, University of Minnesota'This book will be essential reading for anyone interested in charged polymers, including biomolecules such as intrinsically disordered proteins and nucleic acids. A wonderful resource for bridging the gap between polymer physics and the biomolecular sciences. Finally a comprehensive treatment of this important topic that is accessible to a broad audience' Ben Schuler, University of Zurich'An almost encyclopedic work on the physics of charged macromolecules, guiding the reader from concepts, theories, through different methodologies and all the way to complicated phenomenologies. An impressive tour-de-force and a must read at the intersection of soft matter and living matter communities.' Rudi Podgornik, Professor Emeritus, University of LjubljanaTable of ContentsPreface; Acknowledgements; 1. Introduction to charged macromolecules; 2. Models of uncharged macromolecules; 3. Water, oil, and salt; 4. Charged interfaces and geometrical objects; 5. Dilute solutions of charged macromolecules; 6. Structure and thermodynamics in homogeneous polyelectrolyte solutions; 7. Dynamics; 8. Self-assembly and phase behaviors; 9. Adsorption, complexation, and coacervation; 10. Gels; 11. Epilogue; Appendices.

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Book SynopsisThis is the textbook and reference resource that instructors, students, and researchers in biomedical optics have been waiting for. Comprehensive and up to date, it covers a broad range of areas in biomedical optics, from light interactions at the single-photon and single-biomolecule levels, to the diffusion regime of light propagation in tissue. Subjects covered include spectroscopic techniques (fluorescence, Raman, infrared, near-infrared, and elastic scattering), imaging techniques (diffuse optical tomography, photoacoustic imaging, several forms of modern microscopy, and optical coherence tomography), and laser-tissue interactions, including optical tweezers. Topics are developed from the fundamental principles of physical science, with intuitive explanations, while rigorous mathematical formalisms of theoretical treatments are also provided. For each technique, descriptions of relevant instrumentation and examples of biomedical applications are outlined, and each chapter benefits from references and suggested resources for further reading, and exercise problems with answers to selected problems.Trade Review'Bigio and Fantini provide a long-needed introduction to the field of biomedical optics and biophotonics, adding spice to the presentation of the basics with historical and etymological gems. The conversational tone of the book is very welcome, and allows room for the clear explanation of subtleties not always clarified in other discussions. The book is a wonderful introduction to the field. It balances rigor with readability. Bravo!' Steven L. Jacques, Oregon Health Sciences University'This book about biomedical optics provides a remarkably comprehensive introduction to the field. The text is carefully and affectionately developed with quantitative rigor, and it is written in a clear, easy-to-understand style that helps students develop intuition. The subject matter covers basics of linear and nonlinear optical spectroscopy, static and dynamic light scattering and more advanced topics such as light transport through highly scattering tissues, acousto-optics and opto-acoustics, and imaging from microscopy to tomography. The book should prove useful as a textbook for courses targeting both advanced undergraduates and graduate students in science, engineering and medicine. It will also be a valuable reference for researchers working at the frontiers of knowledge.' Arjun G. Yodh, University of Pennsylvania'Bigio and Fantini's comprehensive text on biomedical optics provides a wonderful blend of accessible theory and practical guidance relevant to the design and application of biomedical optical systems. It should be required reading for all graduate students working in this area.' Rebecca Richards-Kortum, Rice University, Houston'This textbook provides a broad survey of the field and covers the basics in a remarkably clear and easy to understand style. The authors have used the fundamental principles of physical science to describe subject matter and a quantitative approach for their applications. … I highly recommend this textbook for upper-level undergraduate courses as well as more advanced graduate-level courses on biomedical optics. The book would also be useful for students of the biological sciences and as a reference resource for researchers in biomedical optics.' Reva Garg, Optics and Photonics News'Educators in Biomedical Optics and Biophotonics have been long awaiting a comprehensive text to accompany their teaching in this rapidly growing field and this is as good as it gets. Educators may have their own bias, but this text provides a balanced approach giving due weight to the topics within the field and covering them comprehensively for most undergraduate and graduate courses in the field … There is sufficient depth, detail and reference material for very specialized researchers to use this as their 'bible' and it should be on the desk of every serious educator and researcher in biomedical optics.' Martin Leahy, National University of Ireland, GalwayTable of Contents1. Nomenclature; 2. Overview of tissue optical properties; 3. Introduction to biomedical statistics for diagnostic applications; 4. General concepts of tissue spectroscopy and instrumentation; 5. Autofluorescence spectroscopy and reporter fluorescence; 6. Raman and infrared spectroscopy of vibrational modes; 7. Elastic and quasi-elastic scattering from cells and small structures; 8. Diffuse reflectance spectroscopy at small source-detector separations; 9. Transport theory and the diffusion equation; 10. Continuous-wave methods for tissue spectroscopy; 11. Time-domain methods for tissue spectroscopy in the diffusion regime; 12. Frequency-domain methods for tissue spectroscopy in the diffusion regime; 13. Instrumentation and experimental methods for diffuse tissue spectroscopy; 14. Diffuse optical imaging and tomography; 15. In vivo applications of diffuse optical spectroscopy and imaging; 16. Combining light and ultrasound: acousto-optics and opto-acoustics; 17. Modern optical microscopy for biomedical applications; 18. Optical coherence tomography; 19. Optical tweezers and laser-tissue interactions.

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Book SynopsisCan technology and innovation transform world health? Connecting undergraduate students with global problems, Rebecca Richards-Kortum examines the interplay between biomedical technology design and the medical, regulatory, economic, social and ethical issues surrounding global health. Driven by case studies, including cancer screening, imaging technologies, implantable devices and vaccines, students learn how the complexities and variation across the globe affect the design of devices and therapies. A wealth of learning features, including classroom activities, project assignments, homework problems and weblinks within the book and online, provide a full teaching package. For visionary general science and biomedical engineering courses, this book will inspire students to engage in solving global issues that face us all.Trade Review'As part of the Clinton Global Initiative, Rice University is launching a major initiative in global health technologies to narrow the unconscionable gap in life expectancy between rich and poor. This beautifully written volume by Rebecca Richards-Kortum will inspire and empower the next generation of engineers to make global health their calling. As President Clinton has said, 'today's generation of young people holds more power than any generation before them to make a positive impact on the world.' The next Jonas Salk or Maurice Hilleman will definitely have this book close at hand.' Thomas Kalil, University of California, Berkeley and Clinton Global Initiative'Professor Richards-Kortum has been in the forefront of giving bioengineers a conscience. This book is an excellent first step in educating engineers as to medical problems in the developing worlds and ways in which bioengineers can make a difference.' Paul Yager, Department of Bioengineering, University of Washington, Seattle'Professor Rebecca Richards-Kortum, a world leader of biomedical engineering research, an HHM investigator and NAE member, brings a global message to all scientists, indeed to all citizens of the world. Regardless of our educational background, we should be concerned about world health. Providing better treatment in a positive social environment, caring about the epidemic level of certain diseases and giving cost effective solutions to health management is not just scientifically exciting. It is also our responsibility as citizens of this world! Richards-Kortum makes it crystal-clear that engineers and scientists can provide intelligent solutions to medical problems and can improve the quality of life of our patients, our citizens, no matter where they live. The examples from Botswana or Lesotho are telling of the crisis bioengineers are facing in a global environment … I have shown my prepublication copy of Richards-Kortum's book to high school students and young undergraduates … They left my office inspired, as true, new apostles for better health treatment methods. No other book has made such transformation of young scientists in such a short time … This book will become the most influential biomedical text of our generation.' Nicholas Peppas, Fletcher S. Pratt Chair in Engineering, The University of Texas at Austin'Rebecca Richards-Kortum is one of the brightest and clearest-thinking biomedical engineers of her generation. Several years ago, she turned her attention to the uses of biomedical technology for improving world health. In her teaching, first at the University of Texas and then at Rice University, she was able to refine her observations into a vision for biomedical engineering that moves beyond the world we see each day. Now she has produced a book that will enable all of us to make the leap she made, and to see our power and obligations a bit more clearly. This is the kind of engineering book that comes around only once in a generation.' Mark Saltzman, Yale University'Helping students understand, early in their academic training, what it takes to bring novel, safe, and effective medical technologies to the patient is laudatory. Rebecca Richards-Kortum very nobly succeeds in doing that in the context of resource-challenged environments by writing a very engaging and provocative book. Bravo!' John H. Linehan, Professor of Biomedical Engineering and Medicine, Northwestern University'Biomedical engineers not only need expertise in the science, engineering and mathematics that underlies their field, they must also know the context in which biomedical engineering is practiced. Professor Richards-Kortum skilfully presents the key medical, policy, social and ethical issues that need to be considered in applying biomedical engineering. This is a comprehensive book that addresses biomedical engineering from a truly global perspective and shows students how these important issues affect the design of devices and therapies. This book will also be an important reference for all biomedical engineers.' George Truskey, Biomedical Engineering, Duke University'This outstanding book by Professor Rebecca Richards-Kortum on bioengineering and world health is based on her years of pioneering work and superb teaching on this topic at the University of Texas and Rice University. This pace-setting book focuses on the application of engineering methods and technological advances to medical technologies, with an emphasis on improving human health in the world. With the increasing globalization of science, technology and healthcare, the publication of this book is extremely timely to meet the urgent demand today. This book addresses the important questions of how to use science and technology to solve healthcare problems and how to translate these new healthcare technologies to the bedside. It also considers the important economical, legal and ethical issues associated with developing new medical technologies to improve world health. This is a very valuable book not only for teaching in fields such as bioengineering, but also for reading by the general public. It will have major positive impacts on bioengineering and world health for years to come.' Shu Chien, President of the Biomedical Engineering Society, Chair of the Department of Biomedical Engineering, University of California, San DiegoTable of ContentsPreface; 1. Emerging medical technologies: high stakes science and the need for technology assessment; 2. Bioengineering and technology assessment; 3. Health and economic data: a global comparison; 4. World health and global health challenges; 5. Healthcare systems: a global comparison; 6. Healthcare costs vs time: trends and drivers; 7. The evolution of technology: scientific method, engineering design, and translational research; 8. Prevention of infectious disease; 9. Ethics of clinical research; 10. Technologies for early detection and prevention of cancer; 11. Cost-effectiveness of screening for disease; 12. Technologies for treatment of heart disease; 13. Clinical trial design and sample size calculation; 14. Technology diffusion; 15. Regulation of health care technologies; 16. Future of bioengineering and world health; Index.

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Book SynopsisTo understand and appreciate how the human brain controls movements of the hand, it is important to investigate both the healthy motor behaviour and dysfunction during everyday manipulative tasks. This book provides a contemporary summary of the physiology and pathophysiology of the manipulative and exploratory functions of the human hand.Table of ContentsPart I. Methodology: 1. Analysis of grip forces during object manipulation J. Hermsdörfer; 2. Kinematic assessment of grasping U. Castiello and C. Ansuini; 3. Digit forces in multi-digit grasps V. M. Zatsiorsky and M. Latash; 4. Recordings from the motor cortex during skilled grasping T. Brochier and R. Lemon; 5. Recording of EMG activity in the monkey during skilled grasping T. Brochier and R. Lemon; 6. Transcranial magnetic stimulation investigations of reaching and grasping movements G. Koch and R. C. Rothwell; 7. Neuroimaging of grasping H. H. Ehrsson; 8. fMRI studies of the basal ganglia and precision grip M. B. Spraker, D. M. Corcos and D. E. Vaillancourt; 9. Models for the control of grasping E. Oztop and M. Kawato; Part II. The Physiology of Grasping: 10. The study of hand movements during grasping: a historical perspective M. Jeannerod; 11. Sensory control of object manipulation R. S. Johansson and R. S. Flanagan; 12. Predictive mechanisms and object representations used in object manipulation R. S. Flanagan, K. Merrit and R. S. Johansson; 13. The neurohaptic control of the hand A. Smith; 14. Points for precision grip A. M. Wing and S. J. Lederman; 15. Two hands in object oriented action S. Endo, A. M. Wing and M. Bracewell; 16. Dynamic grasp control during gait P. Gysin, T. R. Kaminski and A. M. Gordon; 17. Development of grasping and object manipulation B. Vollmer and H. Forssberg; 18. The effects of ageing on sensorimotor control of the hand K. Cole; Part III. The Pathophysiology of Grasping: 19. Somatosensory disorders J. Hermsdörfer and D. A. Nowak; 20. Multi-digit grasping and manipulation: effect of Carpal Tunnel Syndrome on force coordination J. A. Johnston and M. Santello; 21. Stroke C. Lang and M. Schieber; 22. Prehension characteristics in Parkinson's disease T. S. Flink and G. E. Stelmach; 23. Grip force analysis in Huntington's disease – a biomarker for clinical trials? R. Reilmann; 24. Traumatic brain injury J. Kuhtz-Buschbeck; 25. Focal hand dystonia S. Prio Richardson and M. Hallett; 26. Cerebellar disorders M. Manto and D. A. Nowak; 27. Tremor L. Timmermann, J. Raethjen and G. Deuschl; 28. Schizophrenia D. A. Nowak; Part IV. Therapy of Impaired Grasping: 29. Stroke therapy D. A. Nowak and J. Hermsdörfer; 30. Functional reorganisation and neuromodulation, C. Grefkes and G. R. Fink; 31. Intensive training of upper extremity function in children with cerebral palsy A. M. Gordon and K. M. Friel; 32. Therapy of sensorimotor dysfunction of the hand in Parkinson's disease R. Wenzelburger; 33. Therapy of focal hand dystonia K. Zeuner, B. Baur and H. R. Siebner; 34. Therapy of idiopathic normal pressure hydrocephalus D. A Nowak.

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Book SynopsisRegenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators lookinTable of ContentsPart I. Basic Principles of Regenerative Pharmacology: 1. Introduction to regenerative pharmacology George J. Christ and Karl-Erik Andersson; 2. Regenerative pharmacology of the bladder David Burmeister, Karl-Erik Andersson and George J. Christ; 3. Mechanical control of adult mesenchymal stem cells in cardiac applications Peter Galie and Jan P. Stegmann; 4. Kidney and bladder regeneration: pharmacological methods Timothy A. Bertram, Belinda J. Wagner and Bert Spilker; Part II. Enabling Technologies for Regenerative Pharmacology: 5. Stem and progenitor cells in regenerative pharmacology Mark E. Furth, Martin K. Childers and Lola M. Reid; 6. Micro- and nano-scale delivery of therapeutic agents for regenerative therapy Justin M. Saul and Benjamin S. Harrison; 7. Bioreactor technologies for tissue engineering a replacement heart valve Stefanie Biechler, Michael J. Yost, Richard L. Goodwin and Jay D. Potts; 8. Incorporation of active factors (pharmacological substances) in biomaterials for tissue engineering Roche de Guzman and Mark Van Dyke; 9. Enabling drug discovery technologies for regenerative pharmacology G. Sitta Sittampalam; 10. Animal models of regenerative medicine J. Koudy Williams, James Yoo and Anthony Atala; Part III. Future Applications of Regenerative Pharmacology: 11. Gap junction mediated therapies to eliminate cardiac arrhythmias Peter R. Brink and Ira S. Cohen; 12. Regenerative cardiac pharmacology: translating stem cell biology into therapeutic solutions Atta Behfar and Andre Terzic; 13. Wound healing and cell therapy for muscle repair J. B. Vella and J. Huard; 14. Regenerative pharmacology of implanted materials and tissue engineered constructs Emily Ongstad, Michael J. Yost, Richard L. Goodwin, Harold I. Friedman, Stephen A. Fann, Gautam S. Chatnekar and Robert G. Gourdie; 15. The past, present, and future of tissue regeneration M. Natalia Vergara and Panagiotis A. Tsonis.

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Book SynopsisEugene Goldfield lays out principles of engineering found in the natural world, with a focus on how components of coordinated structures organize themselves into autonomous functional systems. This self-organizing capacity is one of many qualities which can be harnessed to design technologies that can interact seamlessly with human bodies.Trade ReviewThe book is fact-packed and beautifully crafted… Bioinspired Devices provides a fascinating way into one of biomedicine’s most complex fields. While Goldfield writes with both erudition and elegance, he has a wonderfully popular touch and a keen sense of humor that has him drawing on Wallace and Gromit and Star Trek (and more) to help with key explanations. It is a book that will not only leave you with a deep respect for research into copying nature, but also in awe of nature itself and how it does so much with so little. -- Adrian Barnett * New Scientist *Bioinspired Devices: Emulating Nature’s Assembly and Repair Process is a reliquary of nature’s wonders, exploring how cells, organisms, and living systems form and function. Goldfield explains how new insights about these natural building processes are now being leveraged to create ‘biologically inspired’ engineering innovations, from medical devices to robot swarms. After reading this book, you will look at the world in an entirely new way. -- Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering, Harvard UniversityBioinspired Devices takes us on a fascinating journey between nature and engineering. Goldfield extracts key principles for how living systems grow and function and proposes that they be applied to the design of better machines and prostheses. Combining an incredibly rich set of observations from neuroscience, bioengineering, biomechanics, ecology, and more, this book is a stimulating read for anyone interested in living systems and the construction of biologically-inspired devices. -- Auke Ijspeert, Swiss Federal Institute of Technology at LausanneBioinspired Devices explores modern bioengineering’s dance between technology and nature, illuminating how the concepts of resiliency, self-repair, and environmental harmony are more evident today than ever before. -- Ravi Bellamkonda, Duke UniversityBioinspired Devices presents an original, erudite perspective on how to emulate fundamental characteristics of living systems—self repair, robustness, development, and emergence—in order to engineer bioinspired solutions to neurological disorders. Goldfield builds on his extensive experience with dynamical systems, at Boston Children’s Hospital and via collaborations with Harvard’s Wyss Institute, to discuss challenges and opportunities in unravelling and emulating nature’s principles to build neuroprosthetic devices and pathways to rehabilitation. -- Marc-Olivier Coppens, University College London

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Book SynopsisProvides an introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. This book begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes.Trade Review"The authors did superbly in combining the biophysical processes and corresponding mathematics... This book serves both as a primer and a reference for constructing synthetic biological circuits with special focus on biomolecular feedback. It nicely bridges the gap between fields with a concise biological introduction, and approachable mathematics."--Harold Bien and Gabor Balazsi, Quarterly Review of Biology "This book promises much for the reader with a background in both biochemistry and mathematics. Such a reader will not only learn how to analyse models for bioengineered bimolecular systems but they will have the insights to both build these systems and to 'tune' the biochemistry to obtain desired parameter values."--Mark Nelson, Gazette of the Australian Mathematical SocietyTable of ContentsPreface vii 1 Introductory Concepts 1 1.1 Systems biology: Modeling, analysis and role of feedback 1 1.2 The cell as a system 8 1.3 Control and dynamical systems tools 11 1.4 Input/output modeling 18 1.5 From systems to synthetic biology 22 1.6 Further reading 28 2 Dynamic Modeling of Core Processes 29 2.1 Modeling chemical reactions 29 2.2 Transcription and translation 44 2.3 Transcriptional regulation 55 2.4 Post-transcriptional regulation 70 2.5 Cellular subsystems 81 Exercises 86 3 Analysis of Dynamic Behavior 89 3.1 Analysis near equilibria 89 3.2 Robustness 103 3.3 Oscillatory behavior 113 3.4 Bifurcations 124 3.5 Model reduction techniques 127 Exercises 133 4 Stochastic Modeling and Analysis 139 4.1 Stochastic modeling of biochemical systems 139 4.2 Simulation of stochastic systems 154 4.3 Input/output linear stochastic systems 157 Exercises 164 5 Biological Circuit Components 169 5.1 Introduction to biological circuit design 169 5.2 Negative autoregulation 171 5.3 The toggle switch 177 5.4 The repressilator 180 5.5 Activator-repressor clock 184 5.6 An incoherent feedforward loop (IFFL) 189 5.7 Bacterial chemotaxis 191 Exercises 203 6 Interconnecting Components 205 6.1 Input/output modeling and the modularity assumption 205 6.2 Introduction to retroactivity 206 6.3 Retroactivity in gene circuits 209 6.4 Retroactivity in signaling systems 214 6.5 Insulation devices: Retroactivity attenuation 219 6.6 A case study on the use of insulation devices 236 Exercises 239 7 Design Tradeoffs 243 7.1 Competition for shared cellular resources 243 7.2 Stochastic effects: Design tradeoffs in systems with large gains 253 Exercises 257 Bibliography 259 Index 267

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Book SynopsisThere is now widespread recognition that psychosocial factors play a key role in the aetiology, perpetuation, management and prevention of cumulative trauma disorders CTDs. This text addresses the strength, direction and importance of links between psychosocial factors and CTDs.; The book''s contributors examine critically current research data, identify potential link mechanisms, and recommend measures for control and prevention. Topics covered include socio-organizational psychology, medical anthropology, occupational medicine, rehabilitation, orthopaedics, job stress and ergonomic interventions. The book aims to demystify the concept of the psychosocial, so as to promote and assure effective prevention in the workplace.Table of Contents1. Evidence, Models and Mechanisms 2. Issues for Management, Prevention and Further Research 3. Commentaries

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Book SynopsisPredictive control is a powerful tool in dealing with those processes with large time delays. Generalized Predictive Control GPC is the most popular approach to the subject, and this text discusses the application of GPC starting with the concept of long-range predictive control and its need in medicine particularly automated drug deliveries.; The concept of adaptation is also emphasized with respect to patient-to-patient parameter variations. Subsequent chapters discuss interactions, comparisons and various aspects of GPC. The book concludes by putting into perspective the generic nature of the architecture built around GPC and which provides model-based fault diagnosis with control.Table of ContentsSISO generalized predictive control GPC in muscle relaxation therapy; propofol induced anaethesia - a comparative control study using a derived nonlinear method; multivariate generalized predictive control in the operating theatre; constrained mutlivariate generalized predictive control for anaesthesia - the quadratic programming approach QP; generalized predictive control with feedforward GPCF for multivariate anaesthesia; generalized predictive control with long-range predictive bidentification LRBI for multivariate anaesthesia; a comparative study between multivariable generalized predictive control and intelligent self- organizing fuzzy logic control SFOLC for multivariate anaethesia; generalized predictive control with prespecified set-points in clinical anaesthesia; supervisory generalized predictive control NLGPC for muscle relaxant anaesthesia.

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