Biology, life sciences Books
Harvard University Press The American Horseshoe Crab
Book SynopsisThis book brings together 20 scientists who have worked on all aspects of horseshoe crab biology to compile the first fully detailed, comprehensive view of Limulus polyphemus. An indispensable resource, the volume describes behavior, natural history, and ecology; anatomy, physiology, distribution, development, and life cycle.Trade ReviewOverall, The American Horseshoe Crab is a fine compendium of information, one I will refer to frequently. The volume also provides an essential tool for anyone involved with developing the regulations that will be required to protect this intriguing species in perpetuity. -- Mark S. Garland * Science *[This] has to be the most thorough book on this amazing creature ever written or ever likely to be written. It is a compilation of essays by some of the crab's foremost researchers...It would be a sad loss if this book were destined merely for reference shelves and university libraries. Each section has its entry point for the novice, its tidbit of fascinating information, ripe for mining by anyone with an inquisitive mind. -- Sandy Bauers * Philadelphia Inquirer *Look inside The American Horseshoe Crab and you'll find everything you ever wanted to know about these living trilobite lookalikes from their much filmed shoreline mating to their historic use as fertiliser. This wonderfully illustrated and detailed compendium of information about the horseshoe or king crab is a must for anyone interested in marine arthropods both fossil and living. -- Douglas Palmer * New Scientist *This book is a superbly produced synthesis of modern knowledge, in 15 chapters written by 20 experts. It is fully illustrated, with 33 colour plates and many line drawings, and there is an extensive bibliography...This scholarly text is essential for all serious students of arthropods. And it is eminently readable, too. -- Euan N. K. Clarkson * BBC Wildlife *Table of ContentsPreface Prologue Robert B. Barlow 1. Synchronies in Migration: Shorebirds, Horseshoe Crabs, and Delaware Bay Mark L. Botton and Brian A. Harrington, with Nellie Tsipoura and David Mizrahi Research Note 1.1 Physiological Ecology of Shorebirds during Migration through the Delaware Bay Area Research Note 1.2 The Importance of Weather Systems and Energy Reserves to Migrating Semipalmated Sandpipers 2. Nesting Behavior: A Shoreline Phenomenon H. Jane Brockmann Exhibit 2.1 Questions about Behavior Exhibit 2.2 Decision Making in Animals Exhibit 2.3 Studying Behavioral Adaptations 3. Male Competition and Satellite Behavior H. Jane Brockmann Exhibit 3.1 Language and Explanation in Behavior Exhibit 3.2 The Process of Fertilization Exhibit 3.3 Paternity Analysis in Horseshoe Crabs 4. Seeing at Night and Finding Mates: The Role of Vision Robert B. Barlow and Maureen K. Powers 5. Growing Up Takes about Ten Years and Eighteen Stages Carl N. Shuster, Jr., and Koichi Sekiguchi Exhibit 5.1 Paths Taken: How the Authors Got Started 6. Horseshoe Crabs in a Food Web: Who Eats Whom? Mark L. Botton and Carl N. Shuster, Jr., with John A. Keinath Research Note 6.1 Predation of Horseshoe Crabs by Loggerhead Sea Turtles 7. A History of Skeletal Structure: Clues to Relationships among Species Carl N. Shuster, Jr., and Lyall I. Anderson Exhibit 7.1 Horseshoe Crab Look-Alikes Exhibit 7.2 What Are Horseshoe Crabs? 8. Throughout Geologic Time: Where Have They Lived? Lyall I. Anderson and Carl N. Shuster, Jr. 9. Coping with Environmental Changes: Physiological Challenges David W. Towle and Raymond P. Henry Exhibit 9.1 Cell Volume Regulation or Blood Ion Regulation? Exhibit 9.2 Epithelial Cell Structure and Function Exhibit 9.3 Hemocyanin, the Oxygen-Carrying Protein Exhibit 9.4 Glossary of Terms 10. Diseases and Symbionts: Vulnerability Despite Tough Shells Louis Leibovitz and Gregory A. Lewbart Exhibit 10.1 Dr. Louis Leibovitz Exhibit 10.2 How to Study a Disease Exhibit 10.3 Pathological and Biological Terminology Exhibit 10.4 A Key to the Identification of Diseases of Limulus Exhibit 10.5 Maintaining Limulus in Captivity 11. A Blue Blood: The Circulatory System Carl N. Shuster, Jr. 12. Internal Defense against Pathogenic Invasion: The Immune System Peter B. Armstrong Exhibit 12.1 Glossary 13. Clotting Cells and Limulus Amebocyte Lysate: An Amazing Analytical Tool Jack Levin, H. Donald Hochstein, and Thomas J. Novitsky 14. King Crab Fertilizer: A Once-Thriving Delaware Bay Industry Carl N. Shuster, Jr. 15. Horseshoe Crab Conservation: A Coast-Wide Management Plan Carl N. Shuster, Jr., Mark L. Botton, and Robert E. Loveland Authors and Contributors References Acknowledgments Index
£102.36
John Wiley and Sons Ltd Industrial Microbiology
Book SynopsisOf major economic, environmental and social importance, industrial microbiology involves the utilization of microorganisms in the production of a wide range of products, including enzymes, foods, beverages, chemical feedstocks, fuels and pharmaceuticals, and clean technologies employed for waste treatment and pollution control. Aimed at undergraduates studying the applied aspects of biology, particularly those on biotechnology and microbiology courses and students of food science and biochemical engineering, this text provides a wide-ranging introduction to the field of industrial microbiology. The content is divided into three sections: key aspects of microbial physiology, exploring the versatility of microorganisms, their diverse metabolic activities and products industrial microorganisms and the technology required for large-scale cultivation and isolation of fermentation products investigation of a wide rangeTrade Review"In today's world, it is important that students understand the fundamentals, but it is also important that the application of these concepts be encouraged. Moreover, a vision of how concepts can be applied often fuels thirst for basic knowledge. In this respect, Industrial Microbiology is a valuable text." Paul B Rainey, Times Higher Education Supplement, 29 November 2002 "...fascinating overview of the metabolic diversity of microorganisms and the key roles they play in inudstrial processes...an excellent text for undergraduate students. The chapters are consistently well written and the figures and tables supplement the text very well." Bob Sotak, E-Streams, vol 5, no. 12, December 2002 "In view of the advent of 'modern' biotechnologies, the question 'What is biotechnology?' has been asked and discussed broadly during the last decades. One of the best answers to define those activities that characterize the utilization of microorganisms for the production of enzymes and fermentation products is Industrial Microbiology ... Thus, if you are interested in obtaining a rather sound and at the same time comprehensive introduction to enzyme and fermentation technology, including the necessary basic knowledge of relevant micro-organisms, this text could be a good choice." M Roehr, Acta Biotechnolgica, September 2003 Table of ContentsPreface. Acknowledgements. Introduction To Industrial Microbiology. Part I: Microbial Physiology. 1. Microbial Cell Structure And Function. 2. Microbial Growth And Nutrition. 3. Microbial Metabolism. Part II: Bioprocessing. 4. Industrial Microorganisms. 5. Fermentation Media. 6. Fermentation Systems. 7. Downstream Processing. 8. Product Development, Regulation And Safety. Part III: Industrial Processes And Products. 9. Microbial Enzymes. 10. Fuels And Industrial Chemicals. 11. Health Care Products. 12. Food And Beverage Fermentations. 13. Food Additives. 14. Microbial Biomass Production. 15. Environmental Biotechnology. 16. Microbial Biodeterioration Of Materials And Its Control. 17. Animal And Plant Cell Culture. Index
£69.26
McGraw-Hill Education - Europe Glencoe Biology Student Edition
Book SynopsisThe Glencoe Biology Student Edition is print book. It is written in a student friendly narrative that will equip students to â Meet science standards Performance Expectations (PEâs).â Integrate Science and Engineering Practices into your science classroomâ Supply the Disciplinary Core Ideas (DCIâs)â Correlate your lessons to NGSSâ Encounter STEM projects
£90.24
Princeton University Press The Passenger Pigeon
Book SynopsisAt the start of the nineteenth century, Passenger Pigeons were perhaps the most abundant birds on the planet, numbering literally in the billions. The flocks were so large and so dense that they blackened the skies, even blotting out the sun for days at a stretch. Yet by the end of the century, the most common bird in North America had vanished froTrade ReviewHonorable Mention for the 2015 National Outdoor Book Awards, Nature and the Environment, NOBA Foundation One of The Independent's Best Nature Books of 2014 Selected for the American Scientist Science Book Gift Guide 2014 One of The Seattle Times 8 Books to Put under a Bird-Lover's Tree 2014 One of The Globe and Mail 75 Book Ideas for Christmas 2014 One of TheAustralian.com's "In the Good Books" 2014 "Lavishly illustrated with rare photographs of the birds... This book provides a general introduction to the history of the passenger pigeon through its collection of rare photographs and other visual materials that most people have not seen before."--Devorah Bennu, The Guardian, GrrlScientist "Visually beautiful... Gives a fine account of the species, its biology and its demise."--Adrian Barnett, New Scientist "A handsome, well-produced volume concentrating on paintings and photographs of the long-lost birds."--Rob Hardy, Columbus Dispatch "A beautifully illustrated, elegantly written 'celebration' of the passenger pigeon and the artists who illustrated and photographed the species... It is a haunting tale, and if you want a readable, engrossing but not lengthy account, I highly recommend this book."--Donna Schulman, 10,000 Birds "Informative... A celebration of this departed species through a mix of prose, paintings and photographs... Filled with interesting tidbits."--Herb Wilson, Portland Press Herald "A timely reminder of just how tenuous life can be for a species, regardless of how numerous they might be. This hardback book is beautifully illustrated. Mr. Fuller has put together a complete natural history of the passenger pigeon drawing upon historical illustrations, photographs, specimens, poems, ornithological journal articles and historical accounts."--Penny Miller, A Charm of Finches "A must have for anyone with an interest in this species."--Ian Paulsen, Birdbooker Report "Beautifully illustrated, this easy-to-read book will appeal to anyone who wishes to understand the concept of extinction."--Jennifer J. Meyer, Orange County Register "From start to finish, the text is informative and entertaining and the photos and artwork are fascinating. Whether you've studied the Passenger Pigeon for years or haven't even heard of the species, I would highly recommend this book."--Rob Ripma, Nutty Birder "Beautifully illustrated, including rare archival images as well as haunting photographs of live birds, this is an evocative memorial to one of the great icons of extinction."--Leslie Geddes-Brown, Country Life "If a picture is worth a thousand words, then Errol Fuller's slim book, The Passenger Pigeon, is surely stuffed full of them... It will probably appeal to younger readers, it is a fast read and it could be a satisfying companion volume to the other two passenger pigeon books that have been recently published."--Grrl Scientist "The most visually beautiful [of recently published books on the passenger pigeon] is Errol Fuller's The Passenger Pigeon, which gives a fine account of the species, its biology and its demise."--Adrian Barnett, New Scientist "[It] is THE monograph for the passenger pigeon. I imagine everyone would learn something from this book. I personally was left with a feeling that we should not stand idle and allow mankind to eradicate any other living species. An excellent read, recommended."--Mike King, Gloster Birder "Written with both clarity and feeling. Most impressive is the breadth and depth of research crammed into what is a relatively slim volume... A masterful summary of what we know about this remarkable bird. To read it is a joy, but one tinged with sadness and regret."--Andy Stoddart, Birdwatch "I would highly recommend reading The Passenger Pigeon by Errol Fuller... Beautifully illustrated."--David Lewis, Birds from Behind "The Passenger Pigeon is an excellent introduction to this bird, what made it so special, and the tragedy of its extinction. If you want to learn about the Passenger Pigeon, or just enjoy the art and photographs, then I'd highly recommend it."--Grant McCreary, Birder's Library "This is a book that should be on every reader's shelf as a reminder as to what we have missed; and to help ensure such an avian tragedy does not occur again."--David Saunders, Bird Watching "[I]f you want to learn more about the Passenger Pigeons, this is a great book to have and to share."--North Durham Nature Newsletter "The heartbreaking illustrated history of a bird that, having once numbered in the billions, vanished from the planet in 1914. On the centenary of the species' extinction Fuller, an expert on extinct birds, reflects on what we lost."--Globe and Mail "A book about a long extinct bird could easily have been a dry, academic tome full of dull facts and figures, but Errol Fuller has managed to avoid this, and instead has produced an engaging book to fire the imagination, to encourage empathy with Martha, alone in her cage for the last four years of her life, to provoke outrage that the species was driven to extinction, and above all, a desire to fight to prevent the same fate befalling others."--Andy Mackay, Grebe "A sad and gorgeous book."--Stephen Romei, Australian "Sumptuously illustrated."--Michael McCarthy, Independent "Passenger Pigeon takes just the opposite approach. Though there is an informative and gracefully written text, this handsome volume tells its stories most eloquently in pictures."--Rick Wright, ABA Blog "Writing in a clear, conversational tone, artist/writer Fuller highlights important aspects of this bird's natural history and its remarkable downhill spiral into oblivion. He provides fascinating accounts of the last wild birds; of 'Martha,' the last of her species, who died in the Cincinnati Zoo; and historical testimony from people who observed the birds' enormous flocks firsthand. Illustrated with numerous historical photographs and exquisite artwork (modern and period), this lasting tribute to one of the most magnificent birds to have ever lived will interest anyone who cares about conservation of the natural world."--Choice "In The Passenger Pigeon, Erroll Fuller brings his artist's eye to a recently popular, much-covered, yet little-understood phenomenon... Fuller's vivid account is the one new book on the species you must buy."--Living Bird Magazine "It is easy to read and thought-provoking, and will be of interest to anyone concerned about conservation today."--Ian Woodward,BTO News "Fuller's book will appeal to a much larger audience and is worth the price just for the photos and illustrations... The Passenger Pigeon should make us vow to never lose another species because of our own greed or neglect."--D.R.K., Wildlife Activist "[L]yrical and artistic. Short enough to hold your attention, detailed enough to convey the essential facts, and elegantly presented."--Alan Knox, Scottish BirdsTable of ContentsPROLOGUE 9 INTRODUCTION 10 THE ANNALS OF EXTINCTION 12 IMAGINE 20 THE BIRD 28 THE DOWNWARD SPIRAL 48 EXTINCTION: THE CAUSES 70 THE LAST CAPTIVES 90 MARTHA 110 ART AND BOOKS 122 QUOTATIONS 148 APPENDIX: A MAGNIFICENT FLYING MACHINE 162 ACKNOWLEDGMENTS 170 FURTHER READING 172 INDEX 175
£22.50
Princeton University Press Cells to Civilizations
Book SynopsisCells to Civilizations is the first unified account of how life transforms itself--from the production of bacteria to the emergence of complex civilizations. What are the connections between evolving microbes, an egg that develops into an infant, and a child who learns to walk and talk? Award-winning scientist Enrico Coen synthesizes the growth ofTrade ReviewShortlisted for the 2013 Royal Society Winton Prize for Science Books "This attempt at a grand theoretical synthesis within biology explores the transformative powers and creative forces that have brought about the living world from the first cells to the latest developments in cultural and technological evolution... [Coen's] eloquently written book offers a programmatic synthesis and an empirically grounded proposal for a theory of biology... Cells to Civilizations will stimulate many productive discussions about the origins and development of life in all its complexities."--Manfred D. Laubichler, Science "In Cells to Civilization, [Coen] couples his knowledge of genetics with metaphor and art, likening the unfurling of mutant snapdragon flowers to an artist's brushstrokes on an expanding canvas... The book is packed with fascinating facts... [H]uman cultures and minds are among the most complex information systems in nature, and Coen does a good job of reminding us of their roots in evolution."--John Hawks, New Scientist "The ideas [in Cells to Civilizations] are subtle, possibly significant, and slightly unsettling. What more could a reader wish for?"--Robert Schaefer, New York Journal of Books "[Coen's] prose is every bit as good as Richard Dawkins' or Steve Jones', and his rich illustrations, particularly the way he uses classical and modern art to make his points, refreshes the text and keeps one's focus on the arguments. His clever ideas and engaging and creative writing style suggest that he would make a fascinating dinner companion. I loved this book and will put it on the general reading list for our biology undergraduates. I suspect it will also find resonance with the interested layman."--Charalambos P. Kyriacou, Times Higher Education "Cells to Civilizations is a very approachable and thought-provoking reading for everyone involved in education and science."--Monika Biro, American Biology Teacher "Cells to Civilizations is an intelligent and entertaining book by a distinguished biologist."--Robert C. Richardson, BioScience "[Cells to Civilizations] was thought provoking, informative, and fun to read."--Choice "Clearly written ... intriguing, thought-provoking."--Library Journal "What are the connections between evolving microbes, an egg that develops into an infant, a child who learns to walk, and the rise of Ancient Rome? For many years, scientists have generally thought these great transformations--evolution, development, learning, and cultural change--occurred through different mechanisms. But geneticist Enrico Coen, in his pioneering new book Cells to Civilization, reveals that these transformations revolve around shared core principles and manifest the same fundamental recipe. Coen blends provocative discussion, the latest scientific research, and colourful examples to demonstrate the links between these critical stages in the history of life."--Chemicals & Chemistry "Coen's book is ambitious and stimulating... Cells to Civilizations is good material for conversation and a worthwhile read."--Deniz Erezyilmaz, truthdig.com "Do not be daunted by the scope of the book, which is written for a wide audience, although it contains enough science for biologists and anthropologists to ponder and argue with Coen. For the rest, it is an easy read, particularly as the biology it contains is peppered with vignettes drawn from painting and art history, which act as a guide for the more dry science that forms the meat of the argument."--Alfonso Martinez Arias, Development JournalTable of ContentsINTRODUCTION: A RECIPE FOR CHANGE 1 History and Form 3 Life's Creative Recipe 8 CHAPTER ONE: LOOPS AND LOTTERIES 13 Principle of Population Variation 16 Principle of Persistence 20 Principle of Reinforcement 23 Principle of Competition 24 Combining Principles 29 CHAPTER TWO: FROM GENES TO ECOSYSTEMS 34 Principle of Cooperation 36 Principle of Combinatorial Richness 40 Wandering Clouds 44 Principle of Recurrence 48 The Origin of Species 52 Species and Ecosystems 57 A Recipe for Evolution 58 CHAPTER THREE: CONVERSATIONS OF AN EMBRYO 61 Turing's Principles 63 Patterning a Cell 68 Switching Genes On and Off 70 A Molecular Fight 73 Looking into Gradients 76 A Common Form 80 CHAPTER FOUR: COMPLETING THE PICTURE 84 An Embryonic Cocktail Party 85 A Cooperative Eff ort 87 Regulatory Riches 88 Building on the Past 90 The Expanding Canvas 93 Deformation 97 The Three-Dimensional Canvas 105 A Common Recipe 108 CHAPTER FIVE: HISTORY IN THE MAKING 111 Unicellular Beginnings 114 Moving up a Scale 115 Zooming and Growing 118 A Recipe within a Recipe 120 CHAPTER SIX: HUMBLE RESPONSES 122 Making Adjustments 124 Flora's Story 127 The Bite of Venus 132 The Sensible Sea Slug 135 Patterns in Time 140 Human Responses 143 Carving up the World 147 CHAPTER SEVEN: THE NEURAL SIBYL 150 The Prophetic Dog 152 Predictive Neurons 155 Learning from Discrepancies 157 Pavlov and Punishments 163 Core Principles 164 A Neural Journey 168 Staying on the Move 169 A Recipe for Learning 173 CHAPTER EIGHT: LEARNING THROUGH ACTION 175 Calibration 176 Jumping Eyes 178 Visual Shifts 181 Learning to Calibrate 184 Action-Learning Loops 187 Smooth Movements 188 An Active Journey 193 Learning with Others 197 CHAPTER NINE: SEEING AS 200 The Neural Eye 204 Multiple Eyes 208 Seeing through Models 211 Learning at Many Levels 213 Top-down and Bottom-up 216 Competing Interpretations 217 A Question of Style 220 Creative Acts 228 CHAPTER TEN: FRAMING RECIPES 232 Development of Learning 233 Basic Instincts 237 Flexibility versus Directness 242 CHAPTER ELEVEN: THE CRUCIBLE OF CULTURE 244 The Apprentice 245 Fruitful Populations 248 Lasting Change 250 Cultural Reinforcement 252 The Force of Competition 254 Cooperative Eff orts 255 A Cultural Mix 257 Propelled by the Past 260 A Cultural Recipe 263 CHAPTER TWELVE: THE GRAND CYCLE 266 Cultural Origins 267 Possible Worlds 270 Nature's Self-Portrait 275 Acknowledgments 281 Notes 283 References 299 Illustration Credits 307 Index 313
£17.09
Princeton University Press Mate Choice
Book SynopsisTrade Review"Mate Choice represents an ambitious synthesis of our current understanding of sexual selection in a broad range of life forms. . . . The book provides a clear synthesis of the state of affairs in the study of mate choice and related fields." * Science *"Rosenthal does an admirable job refocusing decades of work mostly concerned with the effects of (primarily female) mate choice on (primarily male) behavior, physiology, and morphology."---David A. Gray, Quarterly Review of Biology
£45.00
Princeton University Press Visual Ecology
Book SynopsisPresents the study of how animals use visual systems to meet their ecological needs, how these systems have evolved, and how they are specialized for particular visual tasks. This book provides the synthesis of the field to appear in more than three decades.Trade ReviewWinner of the 2015 PROSE Award in Textbook/Biological & Life Sciences, Association of American Publishers "[A] beautiful textbook: aesthetically formatted, clearly written, and with many carefully-chosen (and beautiful to look at!) data images that support the concepts presented in each chapter. This is a wonderful resource for grad students and medical students who want a deeper understanding of vision, advanced undergrads as well as well as the curious (educated) layperson."--Grrrl Scientist "A lovely, splendid book... A superb resource that will serve the field well for years to come, I suspect that I could read this book another 20 times and learn something new with each reading. This book will undoubtedly become required reading for all incoming graduate students in this field. I highly recommend this book for anyone interested in how non-human animals see their surroundings."--Rebecca C. Fuller, Ecology "One of the most brilliant textbooks written during the last years."--Brigitte Schoenemann, Anatomy & PhysiologyTable of ContentsList of Illustrations ix Preface xix 1 Introduction 1 2 Light and the Optical Environment 10 3 Visual Pigments and Photoreceptors 37 4 The Optical Building Blocks of Eyes 66 5 The Eye Designs of the Animal Kingdom 91 6 Spatial Vision 116 7 Color Vision 146 8 Polarization Vision 178 9 Vision in Attenuating Media 206 10 Motion Vision and Eye Movements 232 11 Vision in Dim Light 262 12 Visual Orientation and Navigation 289 13 Signals and Camoufl age 313 Glossary 345 References 355 General Index 383 Index of Names 401
£63.00
Princeton University Press How to Find a Habitable Planet
Book SynopsisThe author has worked closely with NASA in its mission to detect habitable worlds outside our solar system. In this book, he introduces readers to the advanced methodologies being used in this extraordinary quest. It is a suitable for those who have ever dreamed of finding other planets like ours - and perhaps even life like ours - in the cosmos.Trade ReviewThis is a very well-written book that serves perfectly as an introduction for the lay reader to astrobiology and the search for life beyond Earth, and it also presents some important and up-to-date material for the specialist researcher. Of particular note for me is Kasting's rebuttal of several aspects of the Rare Earth hypothesis and his discussion of the features that truly are crucial for planetary habitability."--Lewis Dartnell, Times Higher Education" "How to Find a Habitable Planet will fascinate those who care about the evolution of Earth's climate and wonder about how we will eventually detect life--even simple cellular life--elsewhere."--Debra Fischer, Nature "He argues persuasively that Earth's large moon and strong magnetic field are red herrings; neither is a prerequisite for life. The second part of his book is a detailed account of the search for Earth-like exoplanets, and prospects for future success."--New Scientist Kasting's book ... is a readable guide to the many things we have just begun to understand about a solar system."--Tim Radford, The Guardian "Kasting, a key planner for future NASA missions seeking Earth-like exoplanets, possesses a deep understanding of all the multifarious complexities that feed into forming--and finding--living worlds. He writes about these topics, for all their profundity, with remarkable precision and clarity, drawing clear linkages between what we observe through telescopes with what we see right here, in the only biosphere we know. How to Find a Habitable Planet is a canonical guide to the probable future of humanity's search for life elsewhere in the Universe."--SEED Magazine "A 'popular textbook', low on speculation but high on nuts-and-bolts science, it covers everything from the habitable zones around other stars to how to find other Earths. If I had to choose just one of these books, it would be Kasting's."--Marcus Chown, BBC Focus Magazine "Written in a clear and often conversational style--and infused throughout with Kasting's personal optimism regarding the existence of, and our ability to detect, habitable and inhabited worlds beyond our own--this is an informative and worthwhile read for anyone who looks to the stars and wonders if there is anybody out there."--Tori M. Hoehler, Nature Geoscience "As Kasting shows in his technical but readable How to Find a Habitable Planet, we are making rapid progress in discovering planets around distant stars--almost 500 so far."--Clive Cookson, Financial Times "A concise yet thorough scientific explanation of how we can narrow down the search [for habitable planets]... Kasting is a world leader in planetary habitability and works closely with NASA. He gives insight into the latest technology being used to hunt for habitable plants, describes the signatures of life that scientists are looking for and makes his predictions for the future of the field... Thorough and interesting."--Cosmos Magazine "An excellent book on a fascinating topic."--Choice Even if you were not interested in finding intelligence elsewhere in the universe, How to Find a Habitable Planet provides an excellent and accessible account of the formation and history of our own planet, and indeed our solar system."--John Gribbin, Literary Review "In How to Find a Habitable Planet, James Kasting begins by describing various factors that geophysicists, astrobiologists and others have deemed necessary (or at least desirable) for producing planets capable of supporting life... How to Find a Habitable Planet offers an eloquent explanation of why such a mission would still be desirable."--Physics World "[Kasting is] an excellent writer, capable of breaking down complex topics into clear and accessible pieces. That skill makes this first-of-its-kind book not just unique but probably indispensible for students and armchair planetologists."--Charlene Brusso, Ad AstraTable of ContentsPreface xi Part I: Introduction 1 Chapter 1: Past Thinking about Earth-Like Planets and Life 3 The Habitable Zone and the Importance of Liquid Water 5 Carl Sagan and the Drake Equation 9 Other Perspectives on Planetary Habitability: Rare Earth and Gaia 11 Part II: Our Habitable Planet Earth 15 Chapter 2: Critical Updates on How Planets Are Built 17 The Conventional Wisdom regarding Planet Formation 18 Where Did Earth's Water Come From? 21 New Models for Planetary Accretion and Delivery of Water 23 Could Earth's Water Have Come from Comets? 25 An Up-to-Date Simulation of Planetary Accretion 28 Chapter 3: Long-Term Climate Stability 32 Solar Evolution Theory 32 Solar Mass Loss? 36 Electromagnetic Radiation and the Greenhouse Effect 37 Planetary Energy Balance 41 The Faint Young Sun Problem 42 Possible Solutions to the Problem 45 The Carbonate- Silicate Cycle and Controls on Atmospheric CO2 49 The CO2-Climate Feedback Loop 53 Chapter 4: More Wrinkles in Earth's Climate History 57 The Phanerozoic Climate Record 58 Precambrian Climate 63 Geologic Evidence for the Rise of Atmospheric O2 65 Cause of the O2 Rise: Cyanobacteria 68 Methane, Methanogens, and the Universal Tree of Life 71 The Archean Methane Greenhouse 75 The Paleoproterozoic Glaciation 77 Chapter 5: Runaway Glaciation and "Snowball Earth" 80 Milankovitch Cycles and the Recent Ice Ages 81 Ice Albedo Feedback and Climatic Instability 86 Evidence for Low- Latitude Glaciation 88 Mechanisms for Explaining Low- Latitude Glaciation 90 Snowball Earth 92 Part III: Limits to Planetary Habitability 97 Chapter 6: Runaway Greenhouses and the Evolution of Venus' Atmosphere 99 The History of Water on Venus 100 The Classical Runaway Greenhouse Effect 103 An Alternative Runaway Greenhouse Model 106 Evolution of Venus'Atmosphere 111 Chapter 7: The Future Evolution of Earth 116 High- CO2 Atmospheres and Temperature Limits for Life 116 Future Solar Evolution and Lifetime of the Biosphere 118 A Geoengineering Solution to Solar Luminosity Increases 121 Chapter 8: The Martian Climate Puzzle 125 Evidence for Liquid Water near Mars'Surface 126 CH4 in Mars'Atmosphere? 130 Evidence That Water Flowed in Mars'Distant Past 131 When Did the Martian Valleys Form? 135 How Warm Was Early Mars? 136 Mechanisms for Warming Early Mars 138 Where Are the Carbonates? 144 Chapter 9: Is the Earth Rare? 147 Planetary Size / Magnetic Fields 147 Ozone and Ultraviolet Radiation 152 Availability of Nitrogen and the Importance of N2 155 Is Plate Tectonics Common? 157 A Planet's Impact Environment 161 Stabilization of Earth's Obliquity by the Moon 164 Chapter 10: Habitable Zones around Stars 171 Historical Attempts to Defi ne the Habitable Zone 171 A More Modern Model for the Habitable Zone around the Sun 176 Hertzsprung- Russell Diagrams and Main Sequence Stars 179 Habitable Zones around Other Stars 181 Problems for Planets Orbiting Early- Type Stars 185 Problems for Planets Orbiting Late- Type Stars 188 Further Extensions of the Habitable Zone Concept 191 The Galactic Habitable Zone 192 Part IV: How to Find Another Earth 195 Chapter 11: Indirect Detection of Planets around Other Stars 197 Barnard's Star 198 The Astrometric Method 199 Pulsar Planets 205 The Doppler Effect 207 The Radial Velocity Method 210 Gravitational Microlensing 216 Chapter 12: Finding and Characterizing Planets by Using Transits 221 Transits of Mercury and Venus 221 Transits of Extrasolar "Hot Jupiters" 222 Space- Based Transit Searches: CoRoT and Kepler 227 Observing Exoplanet Atmospheres during Transits 229 Secondary Transit Spectroscopy 233 Characterizing Earth- Like Planets around M Stars 235 Chapter 13: Direct Detection of Extrasolar Planets 239 What Wavelength Region Should We Choose? 240 Infrared Interferometers: TPF- I and Darwin 245 Searching for Planets at Visible Wavelengths TPF- C 248 The Visible Occulter: TPF- O 253 Nearby Target Stars 254 Chapter 14: The Spectroscopic Search for Life 258 Spectral Resolution 259 The Visible / Near- IR Region: TPF- C or -O 260 The Thermal- IR Region: TPF- I or Darwin 266 Looking for Life on Early Earth- Type Planets 269 Possible False Positives for Life 271 Polarization Measurements: Looking for the Glint of Surface Water 274 The Holy Grail: Simultaneous Detection of O and Reduced Gases 276 Chapter 15: Prospects for the More Distant Future 284 NASA's Life Finder Mission 284 Using the Sun as a Gravitational Lens 287 The Drake Equation Revisited: The Search for Extraterrestrial Intelligence 290 Notes 299 Index 317
£999.99
Distant Mirror The Soul of the White Ant
£14.09
Metropolis Ink The Blood and Its Third Element
£15.82
University of California Press Becoming Judy Chicago A Biography of the Artist
Book SynopsisBorn to Jewish radical parents in Chicago in 1939, Judy Cohen grew up to be Judy Chicagoone of the most daring and controversial artists of her generation. Her works, once disparaged and misunderstood by the critics, have become icons of the feminist movement, earning her a place among the most influential artists of her time. In Becoming Judy Chicago, Gail Levin gives us a biography of uncommon intimacy and depth, revealing the artist as a person and a woman of extraordinary energy and purpose. Drawing upon Chicago's personal letters and diaries, her published and unpublished writings, and more than 250 interviews with her friends, family, admirers, and critics, Levin presents a richly detailed and moving chronicle of the artist's unique journey from obscurity to fame, including the story of how she found her audience outside of the art establishment. Chicago revolutionized the way we view art made by and for women and fundamentally changed our understanding of women's contributions to art and to society. Influential and bold, The Dinner Party has become a cultural monument. Becoming Judy Chicago tells the story of a great artist, a leader of the women's movement, a tireless crusader for equal rights, and a complicated, vital woman who dared to express her own sexuality in her art and demand recognition from a male-dominated culture.Trade Review"The sections of the book covering Chicago’s artistic feminist awakening. . .are the best kind of biography—both juicy and educational, full of social and historical context, but also just a dash of gossip (open marriages, feuds with other artists, affairs)." * Hyperallergic *
£22.50
Brandeis University Press Diamonds in the Marsh - A Natural History of the
Book SynopsisA new edition of a classic on a beloved turtle species. She's the mascot for the University of Maryland's sports teams and her ancestors were nearly driven to extinction by Victorians who indulged in turtle soup. But as she buries herself in the mud every night to sleep, the diamondback terrapin knows none of this. The size of a dinner plate and named for the beautiful concentric rings on her shell, she can live at least forty years and is the only turtle in North America who can live in brackish and salty waters. Several diamondback populations have been the subjects of ecological studies in recent years, but most of that information was buried in scientific literature and various state and federal reports-until this book. Synthesizing all known research on this remarkable animal, Diamonds in the Marsh is the first full-scale natural history of the diamondback terrapin. Focusing on the northern diamondback, Barbara Brennessel examines its evolution, physiology, adaptations, behavior, growth patterns, life span, genetic diversity, land use, reproduction, and early years. She also discusses its relationship to humans, first as an important food source from colonial times through the nineteenth century, and more recently as a cultural icon, frequently depicted in Native American art and design. She concludes with a look at contemporary hazards to the terrapin and urges continued study of this marvelous creature. Updated with a new introduction by Brennessel, and with a foreword by Bob Prescott, former executive director of Massachusett's Audubon Wellfleet Bay Sanctuary, Diamonds of the Marsh is perfect for those interested in the conservation of a species.Trade Review“Environmentalists, ecologists, and marine biologists will delight in this meticulously detailed but highly readable look at the only North American turtle species that can tolerate the ‘fresh water, salt water, and everything in between.’” * Publishers Weekly *"A serious treatment of the natural history of one of the most beloved creatures of the Eastern Seaboard. . . well illustrated with photographs." * Natural New England Magazine *"A comprehensive natural history such as Diamonds in the Marsh is an invaluable tool in the study and conservation of a species, and can provide a solid foundation for future research, conservation, and management decisions. Brennessel effectively pulls together the bulk of literature on the diamondback and communicates it to the reader in a generally clear, uncluttered fashion so as to make it not only a resource for researchers, but also an interesting read for reptile aficionados." * Herpetological Review *Table of ContentsPreface Acknowledgments Chapter 1. A Decidedly Unique Creature Chapter 2. A Coast-Hugging Turtle Chapter 3. Reproduction: Insurance for Species Survival Chapter 4. The Lost Years Chapter 5. A Clear and Present Danger for the Most Celebrated of American Reptiles Chapter 6. Learning from the Past; Peering into the Future Bibliography Index
£21.85
Cambridge University Press Leading Your Research Team in Science
Book SynopsisTeam leaders should be full of ideas for new research projects and inspire a research group to achieve great results. This practical guide for team leaders, and those who aspire to become team leader, offers a unique approach to help readers develop research and become a more independent and productive investigator. Readers can learn how to recruit and develop talented team members, how to negotiate contracts and manage projects, and how to create wider visibility and publicity for their science. From human resources and project finances, legal affairs and knowledge transfer to public engagement and media performance, the book provides guidance to enhance skills and combine them with those of support staff on the road to success. With numerous valuable tips, real-life stories and practical exercises, this must-read guide provides everything needed to take responsibility for leading research teams. This title is available as Open Access via Cambridge Core.Table of ContentsPart I. Team: 1. Introduction; 2. Scout; 3. Select; 4. Prepare; 5. Advance; Part II. Organization: 6. Introduction; 7. Human Resources; 8. Financial affairs; 9. Legal affairs; 10. Patent affairs; Part III. Society: 11. Introduction; 12. Open science; 13. Citizen science; 14. Media; 15. Web profile.
£21.99
Spektrum Akademischer Verlag Bild-DVD, Biochemie: Die Abbildungen Des Buches
Book Synopsis
£6.95
St Martin's Press The Great Indoors
Book SynopsisAn Architectural Record Notable BookA fascinating, thought-provoking journey into our built environmentModern humans are an indoor species. We spend 90 percent of our time inside, shuttling between homes and offices, schools and stores, restaurants and gyms. And yet, in many ways, the indoor world remains unexplored territory. For all the time we spend inside buildings, we rarely stop to consider: How do these spaces affect our mental and physical well-being? Our thoughts, feelings, and behaviors? Our productivity, performance, and relationships?In this wide-ranging, character-driven book, science journalist Emily Anthes takes us on an adventure into the buildings in which we spend our days, exploring the profound, and sometimes unexpected, ways that they shape our lives. Drawing on cutting-edge research, she probes the pain-killing power of a well-placed window and examines how the right office layout can expand our social networks. She
£15.30
Princeton University Press The Oceans A Deep History
Book SynopsisTrade Review"Paleoceanography, Rohling’s area of expertise, is the study of ancient oceans and ancient climates as they changed and developed together over geologic time. It involves analyzing data like layers of sediment taken from the seabed. Much alarming information can be learned this way, as Rohling demonstrates, about how today’s oceans are likely to respond to climate change--with greater acidification, sea-level rise, mass extinction and so forth. But because storms leave no geological record, the precise effect of global warming on hurricanes is harder to gauge. Still, Rohling is confident that the combination of rising sea levels and some form of increased storm intensity 'spells doom' for the world’s coastal regions. For surfers, rooting for hurricane swell may be increasingly difficult to rationalize."---James Ryerson, New York Times"Rohling's work is extensive and informative." * Publishers Weekly *"The Oceans is extremely thorough, appropriately so for a topic of such profundity. The book also covers a tremendous amount of ground with dizzying speed." * Foreword Reviews *"If you want to understand the planet and climate change, this book is for you."---John R. Platt, EcoWatch"For science readers looking for something new, [The Oceans] is a treat."---John Farrell, Forbes.com"The density of information and Rohling’s clear, concise explanations make for exhilarating reading, not least because his delight in his subject matter is so palpable. Most importantly though, Rohling’s long view makes clear the vast scope of the transformation of the oceans taking place around us, underlining not just the effect on ecosystems and biodiversity, but also its geological scale."---James Bradley, The Australian"In an incredibly detailed 262-page hardcover volume titled The Oceans: A Deep History, Rohling shakes up every reader who . . . [dives] into the massive amount of worrisome information"---Judy Siegel-Itzkovich, The Jerusalem Post"The Oceans: A Deep History oozes with the enthusiasm and passion that Eelco has for geology and palaeoceanography and the awe that he has for how the Earth came to be what it is today. . . . A brilliantly masterminded book, full of necessary detail that builds a compelling argument from 4.6 billion years of evidence and which culminates in an undeniable conclusion."---Jennifer D. Stanford, The Holocene"This book is not only an invaluable introduction to the cutting-edge science of palaeoceanography but also a crucially important text for students approaching all different fields of marine sciences."---Roberto Danovaro, Current Biology Magazine"Very informative, extensive, and full of necessary detail . . . . this book clearly teaches the many relevant lessons needed to understand the climate change of today and what happens when our atmosphere and oceans change."---Miguel Furtado, Conservation Biology
£22.50
John Wiley & Sons Inc Neocortical Neurogenesis in Development and
Book SynopsisTable of ContentsCortical Progenitors and Germinal Zones 1 Neural stem cells as glia. 2 Diversity and evolution of human cortical progenitor cell types. 3 Intermediate progenitors in neocortical development and evolution. 4 Area V1 development, a model system to link corticogenesis to adult cortex structure and function? 5 Neocortical neurogenesis in amniote evolution. 6 Dynamic transcriptional control of neural stem cells. 7 Mechanical and physical interactions involving neocortical progenitor cells. 8 The role of human-specific genes and amino acid substitutions for neocortex expansion and modern human vs. Neanderthal differences in neocortical neurogenesis. Progenitor Lineages 9 Temporal scaling: a link between conserved neurogenic processes and differential size in mammalian cortical development. 10 Interplay of cell-autonomous gene function and tissue-wide mechanisms regulating radial glial progenitor lineage progression. Generation of Neuron Types 11 Generation of projection neuron diversity in the neocortex: from embryos to organoids. 12 Development of cortical neuron heterogeneity and impact of neurodevelopmental disorders. 13 Developmental and evolutionary origins of cortical projection neuron identity and connectivity. 14 Intrinsic and input-dependent development of cortical neuron types. 15 Corpus callosum evolution and development. 16 Towards the transcriptionally-based classification of L6b in the adult mouse brain. Neuron Migration 17 Cortical neuron migration in health and disease. 18 The emerging roles of LIS1 biomechanics in cellular and cortical homeostasis. Neural Patterning, Specification of Cortical Regions 19 Understanding human forebrain morphogenesis and early expansion using organoids. 20 Early neuronal differentiation/patterning of the human pallium, modeling by in vitro systems, and disruption in developmental disorders. 21 Mammalian cortical regional specification. 22 Development of the neocortical area map. Cortical Folding 23 Old models know wrinkles best -- A critical review on the mechanisms of cortical gyrification 24 Investigation of the mechanisms underlying the development and evolution of the cerebral cortex using gyrencephalic ferrets. Cortical Development: Variations, Disorders and Malformations 25 Genetic variation altering cortical progenitor function leads to human brain evolution and interindividual differences in human brain structure. 26 Human neocortical evolution and neurological disorders 27 Clinical and molecular overview of cortical malformations. Overarching Topics 28 Post-transcriptional control of brain development. 29 Regulation of mRNA localization and translation in brain development: Implications for the mechanism leading to the brain evolution and pathogenesis. 30 The roles of signal transduction during cortical neurogenesis. 31 Centrosome regulation and function in the developing neocortex. 32 Keeping the cortex afloat: Cerebrospinal fluid contributions to cerebral cortical development. 33 Comparative cognitive neuroscience and dorsal and ventral streams in primates.
£162.90
Princeton University Press Species Tree Inference
Book SynopsisTrade Review"A very well-constructed reference book."---April Marie Wright, Trends in Ecology & Evolution"A very good and thorough overview of methods and applications to infer evolutionary relationship between recently diverged taxa." * Conservation Biology *
£37.80
£13.22
Princeton University Press Enchanted by Daphne
Book SynopsisTrade Review"A Choice Outstanding Academic Title of the Year""In more than 40 years of painstaking measurements, the Grants mapped how serendipitous changes in weather and habitat changed the lives and beaks of finches. Peter Grant is similarly attuned to the role of happenstance in his own life."---Emily Bobrow, Wall Street Journal"[Leaves] the impression that the Grants are interesting, unassuming people you'd like to meet."---M. Gochfeld, Choice
£27.00
Taylor & Francis Ltd Designers Guide to Lab Practice
Book SynopsisThis book explores the growing field of bio-design through interdisciplinary creative practice. The volume illustrates a range of experimental working techniques while offering a foundational understanding of lab practice principles. The book highlights the myriad of opportunities presented by microorganisms that have reshaped the planet and made it habitable.The book provides an account of the creation of living materials from the point of view of an architectural design practitioner. The transition from traditional design practice to laboratory investigation is captured, highlighting strategies of creating partnerships across a range of fields. The book demonstrates laboratory methods and ways of investigating the development of living materials and celebrates the growing body of practitioners, scientists, activists and anthropologists who are reimagining new strategies for addressing contemporary environmental challenges.Designer''s Guide to Lab Practice loTable of Contents1. This is not the Beginning 2. Design in the Lab 3. Working Methods 4. Experiments in Design 5. Where to Next?
£31.34
Columbia University Press I Have No Enemies
Book SynopsisI Have No Enemies is the definitive biography of Nobel laureate Liu Xiaobo, offering a meticulously researched account of the twists and turns of a remarkable life.Trade ReviewI Have No Enemies is a moving biography of the courageous Liu Xiaobo. Told with affection, insight, and rich details, it shows how a restless boy gradually grew into a man who firmly believed in benevolence and love, "because love produces strength by binding people together." The fluid, exuberant, and well-textured prose make this book a pure pleasure to read. -- Ha Jin, author of A Song EverlastingThis is an extraordinary work: a meticulous portrait of Liu Xiaobo, his intellectual and activist community, and a period in recent Chinese history notoriously hard to research. It is moving—and essential—reading, reflecting people’s incredible tenacity in pursuing their rights and freedoms even in the face of unyielding repression. -- Sophie Richardson, China director at Human Rights Watch and author of China, Cambodia, and the Five Principles of Peaceful CoexistenceThis is sure to be the work of reference on Liu Xiaobo for many years to come. It is meticulously researched, drawing on unequaled access to sources close to Liu Xiaobo as well as a vast body of references that derive from deep familiarity with China’s intellectual scene over the last fifty years. -- Sebastian Veg, author of Minjian: The Rise of China's Grassroots IntellectualsA moving and well researched biography... meticulously covers an incredible amount of extremely sensitive topics which range from corrupt officials, discrimination against various groups and heavy matters related to human trafficking and police brutality. * East West Notes *Meticulously researched and wonderfully crafted... -- Yang Su * Foreign Affairs *The best biography ever written on the Nobel Peace Prize laureate...an absolute must-read... -- Jean-Philippe Béja * The China Quarterly *Table of ContentsAcknowledgmentsA Note on NamesChronology1. Arrest, Trial, and the Road to a Nobel Prize2. Rebel in Embryo3. Puppy Love and Serious Reading4. College Years, and the Mask of Mao Falls5. Aesthetics and Human Freedom6. Mutiny! A Dark Horse Soars7. Gods and Demons Wrestle8. Out Into the World9. In Tiananmen Square10. A “Black Hand” Goes to Prison, Feels Deep Remorse11. Picking up and Starting Over12. Love That Jumps Walls13. In the Service of Underdogs14. Cascading Cases Build a Movement15. An Intellectual Transition16. Stability Maintenance17. Observing the World, Growing at Home18. The Gathering Storm19. Charter 0820. The World Watches a PrisonEpilogue: The Legacy of Liu XiaoboA Final Note from Wu DazhiNotesIndex
£28.50
Potter/Ten Speed/Harmony/Rodale Quantum Body
Book SynopsisJoining forces with two leading scientists, New York Times bestselling author Deepak Chopra offers a quantum leap for improving our physical and mental health. In an unprecedented collaboration between three of today’s most powerful minds, Deepak Chopra, M.D., teams up with physicist Jack Tuszynski, Ph.D., and endocrinologist Brian Fertig, M.D., to bring readers a visionary work that delves into the innovative world of quantum science and shows how unlocking its secrets can revolutionize how we live and age—and, ultimately, how we can eradicate disease. The key is the quantum body. Unlike our physical body, which is subject to aging, injury, and decay, the quantum body exists on a sub-atomic level and is the infinite, invisible source of everyday reality that affects your thoughts, feelings, sensations, and biological responses. Without your quantum body, there is no physical body. And this lack of awareness of the most
£18.00
Edinburgh University Press BergsonS Philosophy of Biology
Book SynopsisIn this book, Tano S. Posteraro focuses on Bergson's theory of evolution. He presents an alternative Bergson: not a phenomenologist whose central datum is the conscious experience of lived time or the lived body in time, but a systematic philosopher of biology with a robust, prescient and largely workable evolutionary programme.
£18.99
Princeton University Press Data Science for Neuroimaging
Book Synopsis
£85.00
Johns Hopkins University Press An Illustrated Guide to Dinosaur Feeding Biology
Book SynopsisTrade Review...a comprehensive and fascinating insight for all into the lives of these enigmatic creatures.—GeoscientistThis technical book gives a detailed and substantial taxon-by-taxon overview of what dinosaur skulls, jaws, and teeth reveal about what, but especially how dinosaurs ate. This is a welcome survey of an otherwise scattered literature that will be invaluable for specialists.—The Inquisitive BiologistTable of ContentsAcknowledgements1. Early Dinosaur Feeding Studies and an Introduction to Mesozoic Landscapes and Dietary Ecology2. Bones, Teeth, Muscle, and the Study of Functional Morphology3. An Overview of Dinosaur Anatomy4. Early Dinosaurs and Non-Tetanuran Theropods5. Early Tetanuran, Spinosaurid, and Allosauroid Theropods6. Early Coelurosaurian and Tyrannosauroid Theropods7. Maniraptoriform Theropods8. Early Sauropodomorphs and the Rise of Sauropods9. Neosauropods10. Heterodontosaurids and Early Thyreophorans11. Eurypodans12. Early Neornithischians and Ornithopods13. Marginocephalians14. Shaping Dinosaur EcosystemsBibliography
£45.00
Pearson Education Campbell Biology Concepts Connections Global
Book SynopsisMartha R. Taylor has been teaching biology for more than 35 years. She earned her B.A. in biology from Gettysburg Collegeand her M.S. and Ph.D. in science education from Cornell University. At Cornell, Dr. Taylor has served as assistant director of the Office ofInstructional Support and has taught introductory biology for both majors andnonmajors. Most recently, she was a lecturer in the Learning Strategies Center, teaching supplemental biology courses. Her experience working with students inclassrooms, in laboratories, and with tutorials has increased her commitment tohelping students create their own knowledge of and appreciation for biology. She was the author of the Student Study Guide for ten editions of Campbell Biology. Eric J. Simon is a professor in the Department of Biology and Health Science at New England College in Henniker,New Hampshire. He teaches introductory biology to science majors and non rsity, and a Ph.D. in biochemistry
£82.05
Princeton University Press Spark
Book SynopsisTrade Review"Finalist for the PROSE Award in Popular Science and Popular Mathematics, Association of American Publishers""[A] remarkably diverse story . . . full of vitality."---Andrew Robinson, Lancet"[A] chatty, wide-ranging tour of electricity’s role in biology and medicine."---Jerome Groopman, The New Yorker"A fascinating history of humanity’s gradual understanding of electricity. . . . Jorgensen’s study is full of entertaining details, and his passion is evident . . . The result is a sparkling reminder of the strange wonders of life." * Publishers Weekly *"Jorgensen weaves together tales of serendipitous revelations, strange misconceptions, and emerging understandings, showing how the ancients’ first impression of electricity’s animating role has been borne out by the discoveries of modern neuroscience."---Laurence A. Marschall, Natural History"A fascinating biomedical approach to the history of knowledge about electricity and its future uses."---E. J. Delaney, Choice
£22.50
McGraw-Hill Education Deja Review Microbiology and Immunology Third
Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Maximum Retention in Minimal Time! This high-yield, rapid-fire Q&A book simulates flashcards in a book to help you review microbiology and immunology for your course exams as well as prepare for the USMLE Step 1. The convenient two-column âœflashcardâ Q&A format reinforces familiar material, while accelerating mastery of commonly tested topics. Youâll efficiently absorb a large amount of pertinent information and streamline study time by focusing only on the correct answers. Ideal for studying when time is limited, Deja Review: Microbiology and Immunology lets you review in a way that helps you cover a lot of questions in a short period of time. Featuresâ Ideal, two-column flashcard-like format helps you revi
£26.59
John Wiley & Sons Inc Structural Biology in Drug Discovery
Book SynopsisWith the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use Trade Review"The book ... is a surprisingly comprehensive, monumental collection of chapters by a number of researchers in the field of drug discovery. ... [Editor Jean-Paul] Renaud was able to see the broad crucial aspects of the field and therefore able to invite excellent scientists to coauthor this book and cover so many aspects and in so much depth." -- Crystallography Reviews, March 2022Table of ContentsList of Contributors Preface Chapter 01: The Evolving Role of Structural Biology in Drug Discovery Chapter 02: A Structural View on Druggability: Experimental and Computational Approaches Chapter 03: Structural Chemogenomics: Profiling Protein–Ligand Interactions in Polypharmacological Space Chapter 04: Fragment-Based Ligand Discovery Chapter 05: Combining Structural, Thermodynamic and Kinetic Information to Drive Hit-to-Lead Progression Chapter 06: Allostery as Structure-Encoded Collective Dynamics: Significance in Drug Design Chapter 07: Biophysical Assessment of Target Protein Quality in Structure-Based Drug discovery Chapter 08: An Industrial Perspective on Protein-Ligand Complex Crystallization Chapter 09: Membrane Protein Crystallization Chapter 10: High-throughput Macromolecular Crystallography in Drug Discovery: Evolving in the Midst of Revolutions Chapter 11: Assessment of Crystallographic Structure Quality and Protein – Ligand Complex Structure Validation Chapter 12: Complementary Information from Neutron Crystallography Studies Chapter 13: Determination of Protein Structure and Dynamics by NMR: State of the Art and Application to the Characterization of Biotherapeutics Chapter 14: NMR Studies of Protein – Small Molecule Interactions for Drug Discovery Chapter 15: Computational Structural Biology for Drug Discovery: Power and Limitations Chapter 16: The Role of Structural Biology in Kinase Inhibitors Drug Discovery Success Chapter 17: Serine Proteinases from the Blood Coagulation Cascade Chapter 18: Epigenetic Proteins as Emerging Drug Targets Chapter 19: Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery Chapter 20: Targeting Protein–Protein Interactions Perspective Chapter 21: Mass Spectrometry-Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs) Chapter 22: Integrating Evolution of Drug Resistance into Drug Discovery: Lessons from the Viral Proteases of HIV-1 and HCV Chapter 23: A Comprehensive Review on Mycobacterium Tuberculosis Targets and Drug Development from a Structural Perspective Chapter 24: Using Crystal Structures of Drug-Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design Chapter 25: Intrinsically Disordered Proteins (IDPs): Targets for the Future? Chapter 26: Cryo-electron Microscopy as a Tool for Drug Discovery in the Context of Integrative Structural Biology Chapter 27: Application of Hard-X-ray Free-electron Lasers for Static and Dynamic Processes in Structural Biology
£223.20
Elsevier Science Agriculture to Zoology
Book SynopsisTable of Contents1. Introduction to Information Literacy in the Life Sciences 2. Scientific Literacy 3. Designing Information Literacy Instruction for the Life Sciences 4. Agriculture and Plant Sciences Information Literacy 5. Marine and Aquatic Sciences Information Literacy 6. Polar (Arctic and Antarctic) Sciences Information Literacy 7. Zoological and Animal Sciences Information Literacy
£999.99
Oxford University Press Living Computers
Book SynopsisThis accessible and entertaining book explores the fundamental connections between life and information and how they emerged inextricably linked, taking the reader on a journey through all the major evolutionary transitions. It records the entire path of how life''s information has evolved, starting from the growing polymers of prelife leading to the first replicators, through RNA and DNA to neural networks and animal brains, continuing through the major transition of human language and writing, into computer clouds, and finally heading towards an unknown future.All currently known life is based on three classes of molecules: proteins - life''s main structural and functional building blocks; DNA - life''s information molecule; and RNA - a molecule that provides the link between these two. Despite the existence of language and the new means of information recording and processing it enabled, at the current stage of life''s evolution, the information stored in the natural repository of oTable of ContentsPreface 1: How to clone oneself? 2: Self-organising molecules 3: Informed self-organisation 4: The simplest life 5: Evolving replicators 6: Life on Earth 7: Evolution as a ratchet of information 8: From DNA to language 9: Epilogue - beyond language
£999.99
Oxford University Press Experimental Evolution and the Nature of
Book SynopsisUncovering the principles governing the origin and fate of biodiversity is the central goal of modern biology. The first edition (2014) of this novel textbook drew on more than two decades of research in microbial experimental evolution to provide a sketch of a general, empirically grounded theory of biodiversity and the first synthetic treatment of experimental evolution. It has since become an indispensable resource to research laboratories around the world as an essential introduction to the field. However, the science has moved on considerably over the last decade and an updated and expanded treatment of the subject is now timely. Three developments bearing directly on the issue of the nature of biodiversity now deserve particular attention and inclusion: (1) The introduction of high-throughput tools to capture the detailed dynamics of genetic variation are revealing that adaptation is a far more complex process than previously anticipated; (2) A rapidly expanding literature on ada
£999.99
Oxford University Press Inc Eugenics
Book SynopsisA concise and gripping account of eugenics from its origins in the twentieth century and beyond.Table of ContentsAcknowledgements List of Illustrations Chapter 1: The World of Eugenics Chapter 2: Intelligence Chapter 3: Reproduction Chapter 4: Race, Class, and Gender Chapter 5: Eugenics after 1945 References Further Reading Index
£9.49
John Wiley & Sons Inc Anatomy Physiology Workbook For Dummies with
Book SynopsisTable of ContentsIntroduction 1 Part 1: The Building Blocks of the Body 5 Chapter 1: The Language of Anatomy & Physiology 7 Chapter 2: The Chemistry of Life 15 Chapter 3: The Cell: Life’s Basic Building Block 35 Chapter 4: Divide and Conquer: Cellular Mitosis 53 Chapter 5: The Study of Tissues: Histology 63 Part 2: Weaving It Together: Bones, Muscles, and Skin 77 Chapter 6: It’s Skin Deep: The Integumentary System 79 Chapter 7: A Scaffold to Build On: The Skeleton 95 Chapter 8: Getting in Gear: The Muscles 127 Part 3: Mission Control: All Systems Go 155 Chapter 9: Feeling Jumpy: The Nervous System 157 Chapter 10: Raging Hormones: The Endocrine System 191 Part 4: Feed and Fuel: Supply and Transport 207 Chapter 11: Spreading the Love: The Cardiovascular System 209 Chapter 12: Keeping Up Your Defenses: The Lymphatic System 231 Chapter 13: Oxygenating the Machine: The Respiratory System 249 Chapter 14: Fueling the Functions: The Digestive System 265 Chapter 15: Filtering Out the Junk: The Urinary System 287 Part 5: Survival of the Species 301 Chapter 16: Why Ask Y? The Male Reproductive System 303 Chapter 17: Carrying Life: The Female Reproductive System 317 Part 6: The Part of Tens 337 Chapter 18: Ten Study Tips for Anatomy and Physiology Students 339 Chapter 19: Ten Fun Physiology Facts 345 Index 351
£15.99
Wiley-VCH Verlag GmbH Bioreactors: Design, Operation and Novel
Book SynopsisIn this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.Table of ContentsPreface xv List of Contributors xvii 1 Challenges for Bioreactor Design and Operation 1 Carl-Fredrik Mandenius 1.1 Introduction 1 1.2 Biotechnology Milestones with Implications on Bioreactor Design 2 1.3 General Features of Bioreactor Design 8 1.4 Recent Trends in Designing and Operating Bioreactors 12 1.5 The Systems Biology Approach 17 1.6 Using Conceptual Design Methodology 20 1.7 An Outlook on Challenges for Bioreactor Design and Operation 29 References 32 2 Design and Operation of Microbioreactor Systems for Screening and Process Development 35 Clemens Lattermann and Jochen Büchs 2.1 Introduction 35 2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation 36 2.2.1 Specific Power Input 37 2.2.2 Out-of-Phase Phenomena 40 2.2.3 Mixing in Microbioreactors 42 2.2.4 Gas–Liquid Mass Transfer 44 2.2.4.1 Influence of the Reactor Material 47 2.2.4.2 Influence of the Viscosity 49 2.2.5 Influence of Shear Rates 50 2.2.6 Ventilation in Shaken Microbioreactors 51 2.2.7 Hydromechanical Stress 52 2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors 53 2.4 Robotics for Microbioreactors 54 2.5 Fed-Batch and Continuous Operation of Microbioreactors 56 2.5.1 Diffusion-Controlled Feeding of the Microbioreactor 56 2.5.2 Enzyme Controlled Feeding of the Microbioreactor 58 2.5.3 Feeding of Continuous Microbioreactors by Pumps 59 2.6 Monitoring and Control of Microbioreactors 60 2.6.1 DOT and pH Measurement 62 2.6.2 Respiratory Activity 63 2.7 Conclusion 66 Terms 67 Greek Letters 68 Dimensionless Numbers 69 List of Abbreviations 69 References 69 3 Bioreactors on a Chip 77 Danny van Noort 3.1 Introduction 77 3.2 Advantages of Microsystems 79 3.2.1 Concentration Gradients 81 3.3 Scaling Down the Bioreactor to the Microfluidic Format 82 3.4 Microfabrication Methods for Bioreactors-On-A-Chip 82 3.4.1 Etching of Silicon/Glass 83 3.4.2 Soft Lithography 83 3.4.3 Hot Embossing 84 3.4.4 Mechanical Fabrication Technique (Or Poor Man’s Microfluidics) 84 3.4.5 Laser Machining 85 3.4.6 Thin Metal Layers 86 3.5 Fabrication Materials 86 3.5.1 Inorganic Materials 86 3.5.2 Elastomers and Plastics 87 3.5.2.1 Elastomers 87 3.5.2.2 Thermosets 87 3.5.2.3 Thermoplastics 87 3.5.3 Hydrogels 88 3.5.4 Paper 88 3.6 Integrated Sensors for Key Bioreactor Parameters 89 3.6.1 Temperature 89 3.6.2 pH 90 3.6.3 O2 90 3.6.4 Co2 90 3.6.5 Cell Concentration (OD) 90 3.6.6 Humidity and Environment Stability 91 3.6.7 Oxygenation 91 3.7 Model Organisms Applied to BRoCs 91 3.8 Applications of Microfluidic Bioreactor Chip 92 3.8.1 A Chemostat BRoC 92 3.8.2 Using a BRoC as a Single-Cell Chemostat 95 3.8.3 Mammalian Cells in the Bioreactor on a Chip 96 3.8.4 Body-on-a-Chip Bioreactors 98 3.8.5 Organ-on-a-Chip Bioreactor-Like Applications 99 3.9 Scale Up 100 3.10 Conclusion 101 Abbreviations 102 References 103 4 Scalable Manufacture for Cell Therapy Needs 113 Qasim A. Rafiq, Thomas R.J. Heathman, Karen Coopman, Alvin W. Nienow, and Christopher J. Hewitt 4.1 Introduction 113 4.2 Requirements for Cell Therapy 115 4.2.1 Quality 115 4.2.2 Number of Cells Required 117 4.2.3 Anchorage-Dependent Cells 118 4.3 Stem Cell Types and Products 119 4.4 Paradigms in Cell Therapy Manufacture 120 4.4.1 Haplobank 121 4.4.2 Autologous Products 121 4.4.3 Allogeneic Products 123 4.5 Cell Therapy Manufacturing Platforms 124 4.5.1 Scale-Out Technology 125 4.5.2 Scale-Up Technology 127 4.6 Microcarriers and Stirred-Tank Bioreactors 128 4.6.1 Overview of Studies Using a Stirred-Tank Bioreactor and Microcarrier System 130 4.7 Future Trends for Microcarrier Culture 136 4.8 Preservation of Cell Therapy Products 138 4.9 Conclusions 139 References 140 5 Artificial Liver Bioreactor Design 147 Katrin Zeilinger and Jörg C. Gerlach 5.1 Need for Innovative Liver Therapies 147 5.2 Requirements to Liver Support Systems 147 5.3 Bioreactor Technologies Used in Clinical Trials 148 5.3.1 Artificial Liver Support Systems 148 5.3.2 Bioartificial Liver Support Systems 149 5.4 Optimization of Bioartificial Liver Bioreactor Designs 152 5.5 Improvement of Cell Biology in Bioartificial Livers 155 5.6 Bioreactors Enabling Cell Production for Transplantation 157 5.7 Cell Sources for Bioartificial Liver Bioreactors 158 5.7.1 Primary Liver Cells 158 5.7.2 Hepatic Cell Lines 161 5.7.3 Stem Cells 161 5.8 Outlook 163 References 164 6 Bioreactors for Expansion of Pluripotent Stem Cells and Their Differentiation to Cardiac Cells 175 Robert Zweigerdt, Birgit Andree, Christina Kropp, and Henning Kempf 6.1 Introduction 175 6.1.1 Requirement for Advanced Cell Therapies for Heart Repair 175 6.1.2 Pluripotent Stem Cell–Based Strategies for Heart Repair 176 6.2 Culture Technologies for Pluripotent Stem Cell Expansion 179 6.2.1 Matrix-Dependent Cultivation in 2D 179 6.2.2 Outscaling hPSC Production in 2D 179 6.2.3 Hydrogel-Supported Transition to 3D 182 6.3 3D Suspension Culture 182 6.3.1 Advantages of Using Instrumented Stirred Tank Bioreactors 182 6.3.2 Process Inoculation and Passaging Strategies: Cell Clumps Versus Single Cells 186 6.3.3 Microcarriers or Matrix-Free Suspension Culture: Pro and Contra 187 6.3.4 Optimization and Current Limitations of hPSC Processing in Stirred Bioreactors 188 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing 189 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors 190 6.6 Conclusion 192 List of Abbreviations 193 References 193 7 Culturing Entrapped Stem Cells in Continuous Bioreactors 201 Rui Tostoes and Paula M. Alves 7.1 Introduction 201 7.2 Materials Used in Stem Cell Entrapment 202 7.3 Synthetic Materials 203 7.3.1 Polymers 203 7.3.2 Peptides 207 7.3.3 Ceramic 208 7.4 Natural Materials 208 7.4.1 Proteins 208 7.4.2 Polysaccharides 209 7.4.3 Complex 211 7.5 Manufacturing and Regulatory Constraints 212 7.6 Mass Transfer in the Entrapment Material 214 7.7 Continuous Bioreactors for Entrapped Stem Cell Culture 216 7.8 Future Perspectives 220 References 221 8 Coping with Physiological Stress During Recombinant Protein Production by Bioreactor Design and Operation 227 Pau Ferrer and Francisco Valero 8.1 Major Physiological Stress Factors in Recombinant Protein Production Processes 227 8.1.1 Physiological Constraints Imposed by High-Cell-Density Cultivation Conditions 227 8.1.2 Metabolic and Physiologic Constraints Imposed by High-Level Expression of Recombinant Proteins 229 8.1.3 Physiological Constraints in Large-Scale Cultures 230 8.2 Monitoring Physiological Stress and Metabolic Load as a Tool for Bioprocess Design and Optimization 230 8.2.1 Monitoring of Physiological Responses to Recombinant Gene Expression Using Flow Cytometry 231 8.2.2 Monitoring of Reporter Metabolites 233 8.2.3 Omics Analytical Tools to Assess the Impact of Recombinant Protein Production on Cell Physiology 233 8.3 Design and Operation Strategies to Minimize/Overcome Problems Associated with Physiological Stress and Metabolic Load 241 8.3.1 Overcoming Overflow Metabolism and Substrate Toxicity 241 8.3.2 Improving the Energy and Building Block Supply 244 8.3.3 Expression Strategies and Recombinant Gene Transcriptional Tuning for Stress Minimization 245 8.4 Bioreactor Design Considerations to Minimize Shear Stress 246 Acknowledgments 247 References 248 9 Design, Applications, and Development of Single-Use Bioreactors 261 Nico M.G. Oosterhuis and Stefan Junne 9.1 Introduction 261 9.2 Design Challenges of Single-Use Bioreactors 263 9.2.1 Material Choice and Testing 263 9.2.2 Sterilization 267 9.2.3 Sensors and Sampling 267 9.2.4 Challenges for Scale-Up and Scale-Down of Single-Use Bioreactors 268 9.2.4.1 Scalability of Stirred Single-Use Bioreactors 270 9.2.4.2 Scalability of Orbital-Shaken Single-Use Bioreactors 273 9.2.4.3 Scalability of Wave-Mixed Single-Use Bioreactors 275 9.2.4.4 Recent Advances in the Description of the Mass Transfer in SUBs 276 9.3 Cell Culture Application 277 9.3.1 Wave-Mixed Bioreactors 277 9.3.2 Stirred Single-Use Bioreactors 278 9.3.3 Orbital-Shaken Single-Use Bioreactors 280 9.3.4 Mass Transfer Requirements for Cell Culture 280 9.3.5 Perfusion Processes in Single-Use Equipment 282 9.3.6 Plant, Phototrophic Algae and Hairy Root Cell Cultivation in Single-Use Bioreactors 284 9.4 Microbial Application of Single-Use Bioreactors 285 9.5 Outlook 288 List of Abbreviations 289 References 290 10 Computational Fluid Dynamics for Bioreactor Design 295 Anurag S. Rathore, Lalita Kanwar Shekhawat, and Varun Loomba 10.1 Introduction 295 10.2 Multiphase Flows 298 10.2.1 Eulerian–Lagrangian Approach 298 10.2.2 Euler–Euler Approach 303 10.2.3 Volume of Fluid Approach (VOF) 304 10.3 Turbulent Flow 305 10.3.1 Reynolds Stress Model 305 10.3.2 k–ε Model 306 10.3.3 Population Balance Model 306 10.4 CFD Simulations 308 10.4.1 Creation of Bioreactor Geometry 308 10.4.2 Meshing of Solution Domain 308 10.4.3 Solver 310 10.5 Case Studies for Application of CFD in Modeling of Bioreactors 310 10.5.1 CaseStudy1:UseofCFDasaToolforEstablishingProcessDesign Space for Mixing in a Bioreactor 311 10.5.2 Case Study 2: Prediction of Two-Phase Mass Transfer Coefficient in Stirred Vessel 313 10.5.3 Case Study 3: Numerical Modeling of Gas–Liquid Flow in Stirred Tanks 315 Summary 318 References 319 11 Scale-Up and Scale-Down Methodologies for Bioreactors 323 Peter Neubauer and Stefan Junne 11.1 Introduction 323 11.2 Bioprocess Scale-Down Approaches 324 11.2.1 A Historical View on the Development of Scale-Down Systems 324 11.2.1.1 Phase 1: Initial Studies of Mixing Behavior and Spatial Distribution Phenomena 325 11.2.1.2 Phase 2: Evolvement of Scale-Down Systems Based on Computational Fluid Dynamics 327 11.2.1.3 Phase 3: Recent Approaches Considering Hybrid Models 328 11.2.2 Scale-Up of Bioreactors 330 11.2.2.1 Dissolved Oxygen Concentration 331 11.2.2.2 Consideration of Similarities and Dimensionless Numbers 332 11.2.2.3 Shear Rate 333 11.2.2.4 Cell Physiology 333 11.2.3 Most Severe Challenges During Scale-Up 333 11.3 Characterization of the Large Scale 334 11.4 Computational Methods to Describe the Large Scale 337 11.5 Scale-Down Experiments and Physiological Responses 340 11.5.1 Scale-Down Experiments with Escherichia coli Cultures 340 11.5.2 Scale-Down Experiments with Corynebacterium glutamicum Cultures 343 11.5.3 Scale-Down Experiments with Bacillus subtilis Cultures 344 11.5.4 Scale-Down Experiments with Yeast Cultures 345 11.5.5 Scale-Down Experiments with Cell Line Cultures 346 11.6 Outlook 346 Nomenclature 347 References 347 12 Integration of Bioreactors with Downstream Steps 355 Ajoy Velayudhan and Nigel Titchener-Hooker 12.1 Introduction 355 12.2 Improvements in Cell-Culture 358 12.3 Interactions with Centrifugation Steps 359 12.4 Interactions with Filtration Steps 360 12.5 Interactions with Chromatographic Steps 361 12.6 Integrated Processes 364 12.7 Integrated Models 366 12.8 Conclusions 367 References 368 13 Multivariate Modeling for Bioreactor Monitoring and Control 369 Jarka Glassey 13.1 Introduction 369 13.2 Analytical Measurement Methods for Bioreactor Monitoring 370 13.2.1 Traditional Measurement Methods 371 13.2.2 Advanced Measurement Methods 372 13.2.2.1 Spectral Methods 372 13.2.2.2 Other Fingerprinting Methods 374 13.2.3 Data Characteristics and Challenges for Modeling 374 13.3 Multivariate Modeling Approaches 376 13.3.1 Feature Extraction and Classification 376 13.3.2 Regression Models 378 13.4 Case Studies 379 13.4.1 Feature Extraction Using PCA 379 13.4.2 Prediction of CQAs 383 13.5 Conclusions 386 Acknowledgments 387 References 387 14 Soft Sensor Design for Bioreactor Monitoring and Control 391 Carl-Fredrik Mandenius and Robert Gustavsson 14.1 Introduction 391 14.2 The Process Analytical Technology Perspective on Soft Sensors 392 14.3 Conceptual Design of Soft Sensors for Bioreactors 394 14.4 "Hardware Sensor" Alternatives 395 14.5 The Modeling Part of Soft Sensors 400 14.6 Strategy for Using Soft Sensors 402 14.7 Applications of Soft Sensors in Bioreactors 403 14.7.1 Online Fluorescence Spectrometry for Estimating Media Components in a Bioreactor 404 14.7.2 Temperature Sensors for Growth Rate Estimation of a Fed-Batch Bioreactor 405 14.7.3 Base Titration for Estimating the Growth Rate in a Batch Bioreactor 407 14.7.4 Online HPLC for the Estimation of Mixed-Acid Fermentation By-Products 409 14.7.5 Electronic Nose and NIR Spectroscopy for Controlling Cholera Toxin Production 411 14.8 Concluding Remarks and Outlook 413 References 414 15 Design-of-Experiments for Development and Optimization of Bioreactor Media 421 Carl-Fredrik Mandenius 15.1 Introduction 421 15.2 Fundamentals of Design-of-Experiments Methodology 422 15.2.1 Screening of Factors 423 15.2.2 Evaluation of the Experimental Design 425 15.2.3 Specific Design-of-Experiments Methods 429 15.3 Optimization of Culture Media by Design-of-Experiments 431 15.3.1 Media for Production of Metabolites and Proteins in Microbial Cultures 432 15.3.2 Media for the Production of Monoclonal Antibodies and Other Proteins in Mammalian Cell Cultures 438 15.3.3 Media for Differentiation and Production of Cells 441 15.3.4 Other Applications to Media Design 443 15.4 Conclusions and Outlook 447 References 448 16 Operator Training Simulators for Bioreactors 453 Volker C. Hass 16.1 Introduction 453 16.2 Simulators in the Process Industry 455 16.3 Training Simulators 456 16.3.1 Training Simulator Types 457 16.3.1.1 Simulators for "Standard" Processes 457 16.3.1.2 Company-Specific Simulators (Taylor-Made Simulators) 457 16.3.1.3 Process Automation and Control 458 16.3.1.4 Training Simulators in Academic Education 458 16.3.2 Training Simulator Purposes 459 16.3.2.1 Training of Process Handling 459 16.3.2.2 Training Simulators Supporting Engineering Tasks 461 16.4 Requirements on Training Simulators 461 16.4.1 Precise Simulation of the Chemical, Biological and Physical Events 462 16.4.2 Realistic Simulation of Automation and Control Actions 462 16.4.3 Real-Time and Accelerated Simulation 463 16.4.4 Realistic User Interfaces 463 16.4.5 Multipurpose Usage 463 16.4.6 Maintainability for User-Friendly Model Updates 464 16.4.7 Adaptability to Modified or Different Processes 464 16.5 Architecture of Training Simulators 464 16.6 Tools and Development Strategies 466 16.7 Process Models and Simulation Technology 468 16.7.1 Process Models 468 16.7.2 Modeling Strategy 471 16.7.3 Software Systems for Model Development 473 16.7.4 Multiple Use of Models 473 16.8 Training Simulator Examples 474 16.8.1 Bioreactor Training Simulator 474 16.8.2 Anaerobic Digestion Training Simulator 477 16.8.3 Bioethanol Plant Simulator 479 16.9 Concluding Remarks 482 References 484 Index 487
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