Biology, life sciences Books

9073 products


  • International Wildlife Management

    Johns Hopkins University Press International Wildlife Management

    1 in stock

    Book SynopsisA call for wildlife conservationists to transcend the boundaries of locality, share best practices, and unite with a common voice to influence global policy. Habitat loss, disease management, predator-human conflict, illegal tradethese are among the many conservation challenges faced by wildlife experts around the world. But how wildlife professionals approach these issues has historically been geographically fragmented. By providing a broad perspective on issues faced by wildlife on an international scale, the authors of International Wildlife Management make vital connections, drawing attention to underlying causes and strategies for mitigation that may look surprisingly similar from Montana to Zimbabwe. Bringing together wildlife professionals from around the globe to discuss shared challenges, International Wildlife Management examines widespread patterns of wildlife loss covers key conservation strategies, including species reintroduction, community engagement, and wildlife commTrade ReviewAs one who often finds himself reading news reports, commentary, and other material on a wide range of wildlife conservation issues, many of which seem mind-bogglingly perplexing in their complexity and – from an amateur's perspective – wholly beyond human capability to solve, I am very excited to see such a book as this now available that can provide not only an insight into how wildlife management professionals approach such challenges, but also that potential solutions are not only possible but are in fact already being tested and implemented in the field.—Johannes E. Riutta, The Well-Read NaturalistInternational Wildlife Management is an excellent book containing 16 chapters, including a 6 page index.—John A. Bissonette, Department of Wildland Resources, Quinney College of Natural Resources, Utah State University, Journal of Wildlife ManagementTable of ContentsList of ContributorsPrefaceAcknowledgments1. International Wildlife: A Global PerspectiveJohn L. Koprowski, Paul R. Krausman, Dun Wang2. Culture, Values, and Governance: Foundations to Systems of Global Wildlife ConservationRonald J. Regan, Shane P. Mahoney, Basile van Havre, Colman O Criodain, Deborah M. Hahn3. Invasive Species: The Challenges of Nonnative Species Establishment and Spread to Native Wildlife PopulationsSandro Bertolino, Lucas A. Wauters, Adriano Martinoli4. Appreciation, Encouragement, and Rating of Wildlife and Nature Conservation on Private LandsDelwin E. Benson, Wouter van Hoven, Yves Lecocq, Bob van den Brink5. Habitat Loss and FragmentationHsiang Ling Chen, Gabrielle Beca, Mauro Galetti, Chiachun Tsai, Wei Hua Xu, Jing Jing Zhang, Patrick Zollner6. Consequences of Climate Change for Wildlife Marta A. Jarzyna, Victoria L. Atkin Dahm, Benjamin Zuckerberg, William F. Porter7. Global Energy Sprawl: Scale and SolutionsJoseph M. Kiesecker, David E. Naugle8. Wildlife Disease Management in the Global ContextSamantha M. Wisely9. The Effects of Wildlife-Based EcotourismWalt Anderson, Marissa C. G. Altmann10. Carnivores, Coexistence, and Conservation in the AnthropoceneDavid Christianson, Menna Jones11. Moving Animals in the Right Direction: Making Conservation Translocation an Effective ToolRonald R. Swaisgood, Carlos Ruiz-Miranda12. Poaching, Illegal Wildlife Trade, and Bushmeat Hunting in India and South AsiaShekhar K. Niraj, Shreya Sethi, S. P. Goyal, Amar N. Choudhary13. Management of Migratory Wildlife and Others Influenced by BorderlandsAndrea Santangeli, Shambhu Paudel14. International Organizations and Programs for Wildlife ConservationJohn F. Organ, Gonzalo Medina-Vogel, Tsuyoshi Yoshida15. Local Approaches and Community-Based ConservationJohn L. Koprowski, José F. González-Maya, Diego A. Zárrate-Charry, Uday R. Sharma, Craig Spencer16. Getting Involved: Advice for Students and Wildlife ProfessionalsRobert A. McCleery, Julie T. Shapiro, Karen Bailey, Thomas K. FrazerIndex

    1 in stock

    £54.40

  • Foundations for Advancing Animal Ecology

    Johns Hopkins University Press Foundations for Advancing Animal Ecology

    15 in stock

    Book SynopsisA look at how wildlife professionals can modernize their approaches to habitat and population management with a fresh take on animal ecology. How can we maximize the probability that a species of wild animal will persist into the future? This audacious book proposes that advancing animal ecologyand conservation itselfdemands that we reenvision our basic understanding of how animals interact with their environments and with each other. Synthesizing where we are and where we need to go with our studies of animals and their environs, Foundations for Advancing Animal Ecology asserts that studies of animal ecology should begin with a focus on the behaviors and characteristics of individual organisms. The book examines the limitations of classic approaches to the study of animal ecology how organisms organize into collections, such as breeding pairs, flocks, and herds how the broader biotic and abiotic environment shapes animal populations, communities, and ecosystems factors underlying thTable of ContentsPreface About the Authors Chapter 1. Operating Concepts for Animal Ecology Chapter 2. The Study of Habitat: A Historical and Philosophical Perspective Chapter 3. Heterogeneity and Disturbance Chapter 4. The Evolutionary Perspective: Linking Habitat to Population Chapter 5. Species Occurrence in Time and Space: Synthesis and Advancement Chapter 6. Managing Wild Animal Populations and Habitats in an Evolutionary and Ecosystem Context Chapter 7. Putting Concepts into Practice: Guidelines for Developing Study Plans Index

    15 in stock

    £51.00

  • Mammalian Paleoecology

    Johns Hopkins University Press Mammalian Paleoecology

    Book SynopsisTrade ReviewThis book is a neatly crafted package that gives the reader all the required background knowledge, while its case studies make for fascinating reading.—Inquisitive BiologistThis book is highly recommended to people who are interested in paleontology of mammals and how this science can help us to understand us how organisms respond and adapt to environmental changes.—Suiform SoundingsTable of ContentsAcknowledgements1. IntroductionPart I: General Principles of Paleoecology2. Old Bones, footprints and trace evidence of life 3. Taphonomy -putting the dead to work4. Determining age and context Part II: Characterizing the ecology of fossil organisms5. On being the right size6. Show me your teeth and I will tell you what you are7. Stable isotopes and the reconstruction of mammalian movement, diet and trophic relationships8. Non-traditional 'fossils'9. Reconstructing past climate Part III: Using paleoecology to understand the present10. The past as prologue: the importance of a deeper temporal perspective in climate change research11. Biodiversity on EarthIndex

    £68.00

  • Housing Copenhagen

    Presses Polytechniques et Universitaires Romandes Housing Copenhagen

    1 in stock

    Book SynopsisA new translation of a leading architect’s magnum opus. Housing Copenhagen is primarily the translation of leading Danish modern architect Kay Fisker’s Kobenhavske Bolygtyper, maintaining the original layout along with drawings and diagrams. The text illustrates the main features of Fisker’s architecture and describes the cultural context within which the exploration of housing types was conducted. The systematic approach, the richness of selected examples, as well as the analytic content, make this book valuable beyond its historic and geographic limits. Due to a renewed interest in the field of housing, the translation will provide students and professionals with a clear and useful instrument for housing design from an architectural and urban perspective. Table of ContentsLuca Ortelli, Kay Fisker's architectureChiara Monterumisi, IntroductionKay Fisker, The evolution of Copenhagen Housing Types

    1 in stock

    £34.20

  • UFOs: Unidentified Aerial Phenomena:

    Springer International Publishing AG UFOs: Unidentified Aerial Phenomena:

    3 in stock

    Book SynopsisUnidentified phenomena in space, in the Earth's atmosphere, and in waters are too important to leave their exploration to the military and scientific laypersons. Their proper scientific study is important for a variety of reasons; in particular, scientists and the public at large need to know the basic facts, to be informed about the way evidence is recorded, and to understand the difference been reliable evidence and fiction, as well as between plausible explanations and fantasy.With this objective, the book surveys the history of UFO observations, the variety of recorded phenomena, and recounts the efforts of investigative commissions and their published findings.Although wild rumors are demystified in the process, this is not an exercise in rumor-bashing. An open and at the same time critical mindset is the key. Many narratives and hypothesis appear implausible relative to our present state of knowledge; but this alone should not lead to their outright exclusion. Thus the author also pays attention to UFO sightings that have so far eluded explanation in terms of known physics or meteorology. Here the reader will encounter some of the more speculative but scientifically tenable proposals, for example, relating to sudden zigzag motion without apparent inertia or recognizable propulsion, yet always with a clear guide to their plausibility. Last but not least, the book outlines plans and suggestions for future research capable of revealing the existence and intentions of extraterrestrial intelligences, outer-space engineers, or technologies so far known only from science fiction.Table of ContentsEarly UFO Sagas and Legends Prior to Trinity (July 1945).- UFO Sagas and Legends from Trinity (July 1945) Until the Robertson Panel (January 1953).- UFO Sagas and Legends After the Robertson Panel Until 2003.- UFO Sagas and Legends After 2003.- Some Visual Photos of Objects that have not (yet?) been Identified.- UFO Perception in the USA and Elsewhere.- Some Flight Characteristics.- Abductions and Experiences.- Crash Retreivals and UFO Materials.

    3 in stock

    £21.84

  • An Introduction to Animal Behaviour

    Cambridge University Press An Introduction to Animal Behaviour

    15 in stock

    Book SynopsisWolves excitedly greet each other as members of the pack come together; a bumble bee uses its long tongue to reach the nectar at the base of a foxglove flower; a mongoose swiftly and deftly bites its prey to death; young cheetahs rest quietly together, very close to sleep. Now in full colour, this revised and updated edition of Manning and Dawkins'' classic text provides a beautifully written introduction to the fundamentals of animal behaviour. Tinbergen''s four questions of causation, evolution, development and function form the fundamental framework of the text, illustrated with fascinating examples of complex behavioural mechanisms. The authors provide accounts of all levels of behaviour from the nerve cell to that of the population. The strengths of An Introduction to Animal Behaviour as a textbook include its clear explanations and concise, readable text and the enthusiasm of the authors for their subject.Trade Review'This introduction to 'the liveliest aspect of all that lives' (as Konrad Lorenz famously called behaviour) covers all the angles one would expect from a biologically oriented approach. It will be of tremendous value to any student seeking to explore what questions this field of research addresses and the many useful insights and concepts it has developed.' Frans de Waal, Emory University, Atlanta'Combining the best of classical ethology with modern developments in behavioural biology, the sixth edition of a famous textbook is enormously welcome. I strongly recommend this beautifully written and illustrated book to students of all ages.' Patrick Bateson, University of CambridgeTable of Contents1. Introduction; 2. The development of behaviour; 3. Stimuli and communication; 4. Decision-making and motivation; 5. Learning and memory; 6. Evolution; 7. Social organization; Index.

    15 in stock

    £42.74

  • Clinical Microbiology

    Taylor & Francis Inc Clinical Microbiology

    5 in stock

    Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.

    5 in stock

    £42.99

  • The North American Model of Wildlife Conservation

    Johns Hopkins University Press The North American Model of Wildlife Conservation

    5 in stock

    Book SynopsisThe foremost experts on the North American Model of Wildlife Conservation come together to discuss its role in the rescue, recovery, and future of our wildlife resources. At the end of the nineteenth century, North America suffered a catastrophic loss of wildlife driven by unbridled resource extraction, market hunting, and unrelenting subsistence killing. This crisis led powerful political forces in the United States and Canada to collaborate in the hopes of reversing the process, not merely halting the extinctions but returning wildlife to abundance. While there was great understanding of how to manage wildlife in Europe, where wildlife management was an old, mature profession, Continental methods depended on social values often unacceptable to North Americans. Even Canada, a loyal colony of England, abandoned wildlife management as practiced in the mother country and joined forces with like-minded Americans to develop a revolutionary system of wildlife conservation. In time, and suTrade ReviewThis new book offers a wealth of valuable [and] accessible information about how North American wildlife has been and is presently managed. Indeed, all those who hold an interest in North American lands and the wide range of wildlife species living thereupon would be very much benefited from discovering for themselves just how those who hold responsibility for these species think about them, what their goals for them are, and how they go about their respective work.—Johannes E. Riutta, The Well-Read NaturalistTable of ContentsAcknowledgmentsAbout the Contributors1 The North American Model of Wildlife Conservation: Setting the Stage for EvaluationShane P. Mahoney, Valerius Geist, and Paul R. Krausman2 North American Ecological History as the Foundation of the ModelValerius Geist and Shane P. Mahoney3 The Social Context for the Emergence of the North American ModelJohn Sandlos4 The Great Early ChampionsJames Peek5 Critical Legislative and Institutional Underpinnings of the North American ModelJames L. Cummins6 The Landscape Conservation MovementWilliam Porter and Kathryn Frens7 Hunting and Vested Interests as the Spine of the North American ModelJames R. Heffelfinger and Shane P. Mahoney8 Science and the North American Model: Edifice of Knowledge, Exemplar for ConservationJames A. Schaefer9 North American Waterfowl Management:An Example of a Highly Effective International Treaty Arrangement for Wildlife ConservationShane P. Mahoney10 Private-Public Collaboration and Institutional Successes in North American ConservationJohn F. Organ11 Social, Economic, and Ecological Challenges to the North American Model of Wildlife ConservationLeonard A. Brennan, David G. Hewitt, and Shane P. Mahoney12 A Comparison of the North American Model to Other Conservation ApproachesRosie Cooney13 The Model in Transition: From Proactive Leadership to Reactive ConservationShane P. MahoneyIndex

    5 in stock

    £54.40

  • The Angel and the Assassin:  The Tiny Brain Cell

    Random House USA Inc The Angel and the Assassin:  The Tiny Brain Cell

    2 in stock

    Book Synopsis

    2 in stock

    £13.29

  • In Vivo NMR Spectroscopy

    John Wiley & Sons Inc In Vivo NMR Spectroscopy

    Book SynopsisPresents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, includingTable of ContentsPreface xv Abbreviations xvii Supplementary Material xxiv 1 Basic Principles 1 1.1 Introduction 1 1.2 Classical Magnetic Moments 3 1.3 Nuclear Magnetization 5 1.4 Nuclear Induction 9 1.5 Rotating Frame of Reference 11 1.6 Transverse T2 and T2 * Relaxation 12 1.7 Bloch Equations 16 1.8 Fourier Transform NMR 17 1.9 Chemical Shift 20 1.10 Digital NMR 23 1.10.1 Analog‐to‐digital Conversion 23 1.10.2 Signal Averaging 25 1.10.3 Digital Fourier Transformation 25 1.10.4 Zero Filling 25 1.10.5 Apodization 26 1.11 Quantum Description of NMR 28 1.12 Scalar Coupling 30 1.13 Chemical and Magnetic Equivalence 33 Exercises 37 References 40 2 In Vivo NMR Spectroscopy – Static Aspects 43 2.1 Introduction 43 2.2 Proton NMR Spectroscopy 43 2.2.1 Acetate (Ace) 51 2.2.2 N‐Acetyl Aspartate (NAA) 52 2.2.3 N‐Acetyl Aspartyl Glutamate (NAAG) 53 2.2.4 Adenosine Triphosphate (ATP) 54 2.2.5 Alanine (Ala) 55 2.2.6 γ‐Aminobutyric Acid (GABA) 56 2.2.7 Ascorbic Acid (Asc) 57 2.2.8 Aspartic Acid (Asp) 58 2.2.9 Branched‐chain Amino Acids (Isoleucine, Leucine, and Valine) 58 2.2.10 Choline‐containing Compounds (tCho) 59 2.2.11 Creatine (Cr) and Phosphocreatine (PCr) 61 2.2.12 Ethanol 62 2.2.13 Ethanolamine (EA) and Phosphorylethanolamine (PE) 63 2.2.14 Glucose (Glc) 63 2.2.15 Glutamate (Glu) 64 2.2.16 Glutamine (Gln) 65 2.2.17 Glutathione (GSH) 66 2.2.18 Glycerol 67 2.2.19 Glycine 68 2.2.20 Glycogen 68 2.2.21 Histidine 69 2.2.22 Homocarnosine 70 2.2.23 β‐Hydoxybutyrate (BHB) 70 2.2.24 2‐Hydroxyglutarate (2HG) 71 2.2.25 myo‐Inositol (mI) and scyllo‐Inositol (sI) 72 2.2.26 Lactate (Lac) 73 2.2.27 Macromolecules 74 2.2.28 Nicotinamide Adenine Dinucleotide (NAD+) 76 2.2.29 Phenylalanine 76 2.2.30 Pyruvate 77 2.2.31 Serine 78 2.2.32 Succinate 79 2.2.33 Taurine (Tau) 79 2.2.34 Threonine (Thr) 80 2.2.35 Tryptophan (Trp) 80 2.2.36 Tyrosine (Tyr) 80 2.2.37 Water 81 2.2.38 Non‐cerebral Metabolites 82 2.2.39 Carnitine and Acetyl‐carnitine 82 2.2.40 Carnosine 84 2.2.41 Citric Acid 86 2.2.42 Deoxymyoglobin (DMb) 87 2.2.43 Lipids 87 2.2.44 Spermine and Polyamines 89 2.3 Phosphorus‐31 NMR Spectroscopy 90 2.3.1 Chemical Shifts 90 2.3.2 Intracellular pH 92 2.4 Carbon‐13 NMR Spectroscopy 93 2.4.1 Chemical Shifts 93 2.5 Sodium‐23 NMR Spectroscopy 96 2.6 Fluorine‐19 NMR Spectroscopy 102 2.7 In vivo NMR on Other Non‐proton Nuclei 104 Exercises 106 References 108 3 In Vivo NMR Spectroscopy – Dynamic Aspects 129 3.1 Introduction 129 3.2 Relaxation 129 3.2.1 General Principles of Dipolar Relaxation 129 3.2.2 Nuclear Overhauser Effect 133 3.2.3 Alternative Relaxation Mechanisms 134 3.2.4 Effects of T1 Relaxation 137 3.2.5 Effects of T2 Relaxation 138 3.2.6 Measurement of T1 and T2 Relaxation 141 3.2.6.1 T1 Relaxation 141 3.2.6.2 Inversion Recovery 141 3.2.6.3 Saturation Recovery 142 3.2.6.4 Variable Nutation Angle 142 3.2.6.5 MR Fingerprinting 143 3.2.6.6 T2 Relaxation 143 3.2.7 In Vivo Relaxation 144 3.3 Magnetization Transfer 147 3.3.1 Principles of MT 149 3.3.2 MT Methods 150 3.3.3 Multiple Exchange Reactions 152 3.3.4 MT Contrast 152 3.3.5 Chemical Exchange Saturation Transfer (CEST) 156 3.4 Diffusion 160 3.4.1 Principles of Diffusion 160 3.4.2 Diffusion and NMR 160 3.4.3 Anisotropic Diffusion 169 3.4.4 Restricted Diffusion 173 3.5 Dynamic NMR of Isotopically‐Enriched Substrates 175 3.5.1 General Principles and Setup 177 3.5.2 Metabolic Modeling 177 3.5.3 Thermally Polarized Dynamic 13C NMR Spectroscopy 184 3.5.3.1 [1‐13C]‐Glucose and [1,6‐13C2]‐Glucose 184 3.5.3.2 [2‐13C]‐Glucose 185 3.5.3.3 [U‐13C6]‐Glucose 187 3.5.3.4 [2‐13C]‐Acetate 187 3.5.4 Hyperpolarized Dynamic 13C NMR Spectroscopy 189 3.5.4.1 Brute Force Hyperpolarization 189 3.5.4.2 Optical Pumping of Noble Gases 190 3.5.4.3 Parahydrogen‐induced Polarization (PHIP) 191 3.5.4.4 Signal Amplification by Reversible Exchange (SABRE) 193 3.5.4.5 Dynamic Nuclear Polarization (DNP) 193 3.5.5 Deuterium Metabolic Imaging (DMI) 196 Exercises 197 References199 4 Magnetic Resonance Imaging 211 4.1 Introduction 211 4.2 Magnetic Field Gradients 211 4.3 Slice Selection 212 4.4 Frequency Encoding 215 4.4.1 Principle 215 4.4.2 Echo Formation 216 4.5 Phase Encoding 219 4.6 Spatial Frequency Space 221 4.7 Fast MRI Sequences 225 4.7.1 Reduced TR Methods 225 4.7.2 Rapid k‐Space Traversal 226 4.7.3 Parallel MRI 229 4.7.3.1 SENSE 230 4.7.3.2 GRAPPA 233 4.8 Contrast in MRI 234 4.8.1 T1 and T2 Relaxation Mapping 236 4.8.2 Magnetic Field B0 Mapping 239 4.8.3 Magnetic Field B1 Mapping 241 4.8.4 Alternative Image Contrast Mechanisms 242 4.8.5 Functional MRI 243 Exercises 245 References 249 5 Radiofrequency Pulses 253 5.1 Introduction 253 5.2 Square RF Pulses 253 5.3 Selective RF Pulses 259 5.3.1 Fourier‐transform‐based RF Pulses 260 5.3.2 RF Pulse Characteristics 262 5.3.3 Optimized RF Pulses 266 5.3.4 Multifrequency RF Pulses 269 5.4 Composite RF Pulses 271 5.5 Adiabatic RF Pulses 273 5.5.1 Rotating Frame of Reference 275 5.5.2 Adiabatic Condition 276 5.5.3 Modulation Functions 278 5.5.4 AFP Refocusing 280 5.5.5 Adiabatic Plane Rotation of Arbitrary Nutation Angle 282 5.6 Multidimensional RF Pulses 284 5.7 Spectral–Spatial RF Pulses 284 Exercises 286 References 288 6 Single Volume Localization and Water Suppression 293 6.1 Introduction 293 6.2 Single‐volume Localization 294 6.2.1 Image Selected In Vivo Spectroscopy (ISIS) 295 6.2.2 Chemical Shift Displacement 297 6.2.3 Coherence Selection 301 6.2.3.1 Phase Cycling 302 6.2.3.2 Magnetic Field Gradients 302 6.2.4 STimulated Echo Acquisition Mode (STEAM) 304 6.2.5 Point Resolved Spectroscopy (PRESS) 307 6.2.6 Signal Dephasing with Magnetic Field Gradients 309 6.2.7 Localization by Adiabatic Selective Refocusing (LASER) 314 6.3 Water Suppression 317 6.3.1 Binomial and Related Pulse Sequences 318 6.3.2 Frequency‐Selective Excitation 321 6.3.3 Frequency‐Selective Refocusing 323 6.3.4 Relaxation‐Based Methods 323 6.3.5 Non‐water‐suppressed NMR Spectroscopy 326 Exercises 327 References 330 7 Spectroscopic Imaging and Multivolume Localization 335 7.1 Introduction 335 7.2 Principles of MRSI 335 7.3 k‐Space Description of MRSI 338 7.4 Spatial Resolution in MRSI 339 7.5 Temporal Resolution in MRSI 341 7.5.1 Conventional Methods 343 7.5.1.1 Circular and Spherical k‐Space Sampling 343 7.5.1.2 k‐Space Apodization During Acquisition 343 7.5.1.3 Zoom MRSI 345 7.5.2 Methods Based on Fast MRI 346 7.5.2.1 Echo‐planar Spectroscopic Imaging (EPSI) 346 7.5.2.2 Spiral MRSI 349 7.5.2.3 Parallel MRSI 350 7.5.3 Methods Based on Prior Knowledge 351 7.6 Lipid Suppression 353 7.6.1 Relaxation‐based Methods 353 7.6.2 Inner Volume Selection and Volume Prelocalization 355 7.6.3 Outer Volume Suppression (OVS) 357 7.7 MR Spectroscopic Image Processing and Display 360 7.8 Multivolume Localization 364 7.8.1 Hadamard Localization 365 7.8.2 Sequential Multivolume Localization 366 Exercises 368 References370 8 Spectral Editing and 2D NMR 375 8.1 Introduction 375 8.2 Quantitative Descriptions of NMR 375 8.2.1 Density Matrix Formalism 376 8.2.2 Classical Vector Model 377 8.2.3 Correlated Vector Model 378 8.2.4 Product Operator Formalism 379 8.3 Scalar Evolution 380 8.4 J‐Difference Editing 384 8.4.1 Principle 384 8.4.2 Practical Considerations 385 8.4.3 GABA, 2HG, and Lactate 389 8.5 Multiple Quantum Coherence Editing 395 8.6 Spectral Editing Alternatives 400 8.7 Heteronuclear Spectral Editing 402 8.7.1 Proton‐observed, Carbon‐edited (POCE) MRS 402 8.7.2 Polarization Transfer – INEPT and DEPT 407 8.8 Broadband Decoupling 410 8.9 Sensitivity 414 8.10 Two‐dimensional NMR Spectroscopy 415 8.10.1 Correlation Spectroscopy (COSY) 416 8.10.2 J‐resolved Spectroscopy (JRES) 422 8.10.3 In vivo 2D NMR Methods 424 Exercises 429 References 432 9 Spectral Quantification 439 9.1 Introduction 439 9.2 Data Acquisition 440 9.2.1 Magnetic Field Homogeneity 440 9.2.2 Spatial Localization 442 9.2.3 Water Suppression 442 9.2.4 Sensitivity 442 9.3 Data Preprocessing 443 9.3.1 Phased‐array Coil Combination 443 9.3.2 Phasing and Frequency Alignment 444 9.3.3 Line‐shape Correction 444 9.3.4 Removal of Residual Water 444 9.3.5 Baseline Correction 446 9.4 Data Quantification 447 9.4.1 Time‐ and Frequency‐domain Parameters 447 9.4.2 Prior Knowledge 450 9.4.3 Spectral Fitting Algorithms 453 9.4.4 Error Estimation 457 9.5 Data Calibration 460 9.5.1 Partial Saturation 461 9.5.2 Nuclear Overhauser Effects 462 9.5.3 Transverse Relaxation 462 9.5.4 Diffusion 462 9.5.5 Scalar Coupling 462 9.5.6 Localization 463 9.5.7 Frequency‐dependent Amplitude‐ and Phase Distortions 463 9.5.8 NMR Visibility 463 9.5.9 Internal Concentration Reference 464 9.5.10 External Concentration Reference 466 9.5.11 Phantom Replacement Concentration Reference 466 Exercises 467 References 469 10 Hardware 473 10.1 Introduction 473 10.2 Magnets 473 10.3 Magnetic Field Homogeneity 478 10.3.1 Origins of Magnetic Field Inhomogeneity 478 10.3.2 Effects of Magnetic Field Inhomogeneity 482 10.3.3 Principles of Spherical Harmonic Shimming 485 10.3.4 Practical Spherical Harmonic Shimming 489 10.3.5 Alternative Shimming Strategies 491 10.4 Magnetic Field Gradients 493 10.4.1 Eddy Currents 498 10.4.2 Preemphasis 499 10.4.3 Active Shielding 503 10.5 Radiofrequency (RF) Coils 503 10.5.1 Electrical Circuit Analysis 503 10.5.2 RF Coil Performance 509 10.5.3 Spatial Field Properties 510 10.5.3.1 Longitudinal Magnetic Fields 512 10.5.3.2 Transverse Magnetic Fields 513 10.5.4 Principle of Reciprocity 514 10.5.4.1 Electromagnetic Wave Propagation 515 10.5.5 Parallel Transmission 517 10.5.6 RF Power and Specific Absorption Rate (SAR) 519 10.5.7 Specialized RF Coils 520 10.5.7.1 Combined Transmit and Receive RF Coils 521 10.5.7.2 Phased‐Array Coils 522 10.5.7.3 1H‐[13C] and 13C‐[1H] RF Coils 522 10.5.7.4 Cooled and Superconducting RF Coils 525 10.6 Complete MR System 526 10.6.1 RF Transmission 526 10.6.2 Signal Reception 527 10.6.3 Quadrature Detection 528 10.6.4 Dynamic Range 529 10.6.5 Gradient and Shim Systems 530 Exercises 531 References 534 Appendix A 541 A.1 Matrix Calculations 541 A.2 Trigonometric Equations 543 A.3 Fourier Transformation 543 A.3.1 Introduction 543 A.3.2 Properties 544 A.3.2.1 Linearity 544 A.3.2.2 Time and Frequency Shifting 544 A.3.2.3 Scaling 545 A.3.2.4 Convolution 545 A.3.3 Discrete Fourier Transformation 545 A.4 Product Operator Formalism 546 A.4.1 Cartesian Product Operators 546 A.4.2 Shift (Lowering and Raising) Operators 548 References 550 Further Reading 551 Index 553

    £99.86

  • Taylor & Francis Handbook of Forensic Toxicology for Medical Examiners

    Out of stock

    a huge range and FREE tracked UK delivery on ALL orders.

    Out of stock

    £999.99

  • Anatomy of Exercise: A Trainer's Inside Guide to

    Firefly Books Ltd Anatomy of Exercise: A Trainer's Inside Guide to

    Out of stock

    Book SynopsisAnatomy of Exercise is revolutionary for its insights into how different muscles of the body actually work during exercise. The book is organised by body area and shows common sequences in the progression of a typical workout. Lifelike anatomical illustrations demonstrate each exercise and reveal in colourful detail exactly which muscles are engaged, which are being conditioned and how those muscles respond. The following features help the reader gain the greatest benefit from each exercise and thereby improve fitness and well-being: Detailed, full-colour anatomical illustrations for all the exercises; Annotations identifying the active and stabilising muscles; Concise how-to instructions for each exercise; Identification of the specific muscles that benefit the most from each exercise; Suggested modifications for different levels of difficulty; Instructions on stabilising the body throughout each movement; A visual index of exercises that allows easy navigation through the book; A glossary of anatomical terms. No other book provides such rich detail tailored to the general reader. Beginners, those already committed to exercise, competing athletes, trainers, coaches, physiotherapists, massage therapists and the many others involved in fitness will find Anatomy of Exercise fascinating, instructive and practical.Trade ReviewAnatomy of Exercise is a fascinating book.... If used correctly the book can help the reader benefit from each exercise and improve their fitness level. Highlights of the book include the detailed, full-color anatomical illustrations, annotations identifying active and stabilizing muscle, suggestions for modifications to vary intensity of an exercise, and a visual index that allows for easy navigation through the book. This book would be useful for anyone interested in enhancing their fitness routine as well as fitness instructors who want to visually show their customers the benefits of each exercise. Therefore, it can be recommended to medium-sized and large public libraries as well as high school and undergraduate collections.--Shannon Graff Hysell "American Reference Book Annual " Curious what the body is doing when it's working out? Fitness expert Manocchia shows readers with a glossary of anatomical terms and detailed color illustrations that identify muscles. Duke, a personal trainer to the stars, has devised diet-and-fitness regimes for women. Distinctive to her approach: her encouragement to appreciate our bodies instead of aiming for an ideal that may not exist.-- (04/22/2008) Exercise books abound -- filled with how-to photos of various exercises. But here's one with a bit of a different focus. Anatomy of Exercise looks at how different muscles of the body actually work during exercise. The book is organized by body area and shows common sequences in the progression of a typical workout. It features life-like anatomical illustrations to demonstrate each exercise and reveal exactly which muscles are engaged, which are being conditioned and how those muscles respond.-- (02/05/2009) [The author's] emphasis on supporting muscles will be helpful to people who tend to injure different muscles, one after another.--Arkansas Democrat-Gazette (04/21/2008) This manual is the ultimate reference on physical fitness for anyone who exercises. Fully illustrated and annotated it's aimed at general readers who want to perform each exercise correctly while helping their muscles, not hurting them.-- (07/01/2008) One of the best books written as a reference manual for understanding exercise... For those of you who want to work out, but are unsure if you are exercising properly, this book is perfect for you.... Great how-to instructions.-- (01/09/2008) This is an excellent book no fitness professional or fitness enthusiast should be without.--New Living (Stony Brook NY) (07/01/2008) This book is a great motivator for the health conscious... Depending on how intensely you get into your routines, Anatomy of Exercise is critical reading for those who want to acquire the best body they can.-- (02/01/2009) For the exercises covered, the author does a good job of explaining proper form. If you were never completely sure the right way to run or ride a stationary bike, this book tells you how in very simple language. The computer-generated illustrations of the muscles recruited to perform each exercise are cool.-- (01/01/2009) This user-friendly guide has everything you need and then some.--2 Magazine (03/01/2008) Provides the answers and shows you exactly what's moving one push-up and cross-over crunch at a time.--Albuquerque Journal (08/10/2008) Read this book and you'll strengthen your mind as well as your body.... This book is like having your own personal trainer right there with you.-- (08/31/2008) [The drawings] make it easy to visualize your muscles in action, even if you are not exactly sure where your anterior deltoid or external obliques are located.--The News-Sentinel (Fort Wayne IN) (07/07/2008)

    Out of stock

    £999.99

  • Microbiology An Introduction Global Edition

    Pearson Education Microbiology An Introduction Global Edition

    15 in stock

    Book SynopsisAbout our authors Gerard J. Tortora (Chapters 1-5 and 14-16) is professor of biology and former biology coordinator at Bergen Community College in Paramus, New Jersey. He received his bachelor's degree in biology from Fairleigh Dickinson University and his master's degree in science education from Montclair State College. He has been a member of many professional organizations, including the American Society of Microbiology (ASM), the Human Anatomy and Physiology Society (HAPS), the American Association for the Advancement of Science (AAAS), the National Education Association (NEA), and the Metropolitan Association of College and University Biologists (MACUB). Above all, Jerry is devoted to his students and their aspirations. In recognition of this commitment, MACUB presented Jerry with the organization's 1992 President's Memorial Award. In 1995, he was selected as one of the finest faculty scholars of Bergen Community College and was named Distinguished Faculty Scholar. In 1996, he received a National Institute for Staff and Organizational Development (NISOD) excellence award from the University of Texas and was selected to represent Bergen Community College in a campaign to increase awareness of the contributions of community colleges to higher education. Jerry is the author of several best-selling science textbooks and laboratory manuals, a calling that often requires an additional 40 hours per week beyond his full-time teaching responsibilities. Nevertheless, he still makes time for four or five weekly aerobic workouts. He also enjoys attending opera performances at the Metropolitan Opera House, Broadway plays, and concerts. He spends his quiet time at his beach home on the New Jersey Shore. To all my children, the most important gift I have: Lynne, Gerard Jr., Kenneth, Anthony, and Drew, whose love and support have been such an important part of my personal life and professional career. Christine L. Case (Chapters 6-13 and 20-28) taught microbiology at Skyline College in San Bruno, California for 51 years. She received her Ed.D. in curriculum and instruction from Nova Southeastern University and her M.A. in microbiology from San Francisco State University. She was Director for the Society for Industrial Microbiology and is an active member of the ASM. She received the ASM and California Hayward outstanding educator awards. Chris received the SACNAS Distinguished Community College Mentor Award for her commitment to her students, several of whom have presented at undergraduate research conferences and won awards. Chris contributes regularly to the professional literature, develops innovative educational methodologies, and maintains a personal and professional commitment to conservation and the importance of science in society. Chris is also an avid photographer, and many of her photographs appear in this book. I owe my deepest gratitude to Don Biederman and our three children, Daniel, Jonathan, and Andrea, for their unconditional love and unwavering support. Warner B. Bair III (In-the-Clinic videos, eText Media Integration, eText assessments, Dynamic Study Modules) is a professor of biology at Lone Star CollegeCyFair in Cypress, Texas. He has a bachelor of science in general biology and a Ph.D. in cancer biology, both from the University of Arizona. He has over 10 years of higher education teaching experience, teaching both general biology and microbiology classes. Warner is the recipient of multiple educational awards, including the National Institute for Staff and Organizational Development (NISOD) excellence award from the University of Texas and the League for Innovation in the Community College John and Suanne Roueche Excellence Award. Warner has previously authored Interactive Microbiology videos and activities for the Mastering Microbiology website and is a member of the American Society for Microbiology (ASM). He is also a certified Instructional Skill Workshop (ISW) facilitator, where he assists other professors in the development of engaging and active classroom instruction. When not working, Warner enjoys outdoor activities and travel. Warner would like to thank his wife, Meaghan, and daughter, Aisling, for their support and understanding of the many late nights and long weekends he spends pursuing his writing. Derek Weber (In-the-Clinic videos, eText Media Integration, eText assessments, Dynamic Study Modules) is a professor of biology and microbiology at Raritan Valley Community College in Somerville, New Jersey. He received his B.S. in chemistry from Moravian College and his Ph.D. in biomolecular chemistry from the University of WisconsinMadison. His current scholarly work focuses on the use of instructional technology in a flipped classroom to create a more active and engaging learning environment. Derek has received multiple awards for these efforts, including the Award for Innovative Excellence in Teaching, Learning and Technology at the International Teaching and Learning Conference. As part of his commitment to foster learning communities, Derek shares his work at state and national conferences and is a regular attendee at the annual American Society for Microbiology Conference for Undergraduate Educators (ASMCUE). He has previously authored MicroBooster Video Tutorials, available in MasteringMicrobiology, which remediate students on basic concepts in biology and chemistry as they apply to microbiology. Derek is grateful to his wife Lara and his children Andrew, James, and Lilly for their unconditional love and support. Berdell R. Funke (1926-2020) received his Ph.D., M.S., and B.S. in microbiology from Kansas State University. He spent his professional years as a professor of microbiology at North Dakota State University. He taught introductory microbiology, including laboratory sections, general microbiology, food microbiology, soil microbiology, clinical parasitology, and pathogenic microbiology. As a research scientist in the Experiment Station at North Dakota State, he published numerous papers in soil microbiology and food microbiology. In December 2019 Bert received an honorary doctorate from NDSU. The Bison statue he was given at the awards ceremony was a source of great pride for him. His name will live on at NDSU through the Berdell Funke Microbiology Scholarship and the Dr. Berdell Funke Medal of Excellence in Microbiology, which is presented each year to an outstanding graduate. We thank Bert and his family for his contributions over the past thirty years to the first edition of Microbiology, An Introduction, and its subsequent editions.

    15 in stock

    £58.49

  • Antarctic Wildlife A Visitors Guide WILDGuides

    Princeton University Press Antarctic Wildlife A Visitors Guide WILDGuides

    Book SynopsisAn identification guide to the birds and marine mammals of the Antarctic Peninsula, Drake Passage, and Beagle Channel. It enables visitors to this region - newcomer and seasoned traveler alike - to identify the penguins, whales, seals, seabirds, and other wildlife they encounter on their journey.Trade Review"A must have guide for those visiting Antarctica!"--Ian Paulsen, Birdbooker Report "An eminently practical, accurate, useable and indispensable field guide perfect to bring on your Antarctic cruise. Or even just to keep on your bedside table... There's a lot of information effortlessly packed into this little powerhouse of a guide... When it comes time to cruise, though, Antarctic Wildlife, A Visitor's Guide is the one to grab."--Cathy Taibbi, Examiner.com "It's difficult to appreciate far off consequences of things like melting polar ice-caps, rising ocean levels, and other effects that happen far away or too slowly for the eye to see. That's one reason why I think books like James Lowen's Antarctic Wildlife, A Visitor's Guide are so important. They help provide context for and appreciation of the Antarctic as more than an abstract concept... Antarctic Wildlife is a window offering a view of the southern end of the world... By revealing its treasures, Lowen reminds us why even the most remote places on Earth are worth defending."--Brad Sylvester, Yahoo! News "Spectacular. It covers all wildlife within Antarctica, not just birds. But for the birders reading this, the section on birds is done well."--Jerry Liguori, Utah Birders blog "The identification text is split into two sections, one basic summary for the amateur and beneath this a more detailed description for the avid enthusiast. The supporting images are excellent, chosen for clear field identification, and it's impressive to note that the author took many of them himself... This is an excellent field guide, well laid out with photos and easy-to-access information... It will definitely accompany me on my next trip to Antarctica."--Luxury Travel Review "Thanks to this book, I now want to go to Antarctica more than ever! And if (hopefully, when) I go, it will not be without this book. Antarctic Wildlife: A Visitor's Guide should be required for any cruise-based visitor to the great white continent. And if you want to risk being compelled to pay big bucks to go on such a cruise, I'd also recommend it to anyone even slightly interested in the wildlife of Antarctica."--Grant McCreary, Birder's Library "Recommended for either the real-world or armchair traveler interested in the natural history of the Antarctic... Portable and approachable."--Jean E. Crampon, Library Journal "With a soft flexible binding perfect for thrusting into a knapsack, this book is a primer for all manner of wildlife one might encounter on the seventh continent... Features glorious full-color photos and is chocka-block with charts and indices, tips on choosing a cruise and the best spots to seek out wildlife, as well as an examination of the environmental threats to the region's indigenous residents. With a lively map as end papers, this book works just as well for the armchair traveler as for the hearty explorer."--Christopher Schoppa, Washington Post "This handy ID guide comes as a timely aid to anyone venturing into the Southern Oceans. It covers the areas usually included in tour itineries, from the southern Tip of Argentina to Antarctica proper. The book uses a photo-montage style for the illustrations, an increasingly popular method, which works well here and covers everything from lichens through to whales and birds, so a truly comprehensive guide. Essential for anyone visiting the area."--About Birds, British Trust for Ornithology "Ideal guide for the first-time visitor... The moment you pick up this book it feels good ... exceedingly well-chosen images... Buy it and then start saving for your trip!"--Birdwatch "[D]oes the job admirably... [S]tunning colour plates... [D]etailed and yet written in an easy-to-read and interesting way."--World Birdwatch "I could write this review in just two simple sentences. If you have already experienced the Antarctic, then after reading James Lowen's visitors' guide, you will be packing your bags and booking your next visit. If you haven't been there before, you will still be packing your bags and booking your visit. It's as simple as that. Antarctic Wildlife is a clean, concise and very practical guide to the wildlife of the Antarctic Peninsula, Drake Passage and Beagle Channel... A refreshing view of this fascinating continent."--David Lindo, Birdwatching Magazine "[A] fantastic guide ... rich in photography... [T]he penguin behaviour gallery is a joy."--Birds "[S]pecifically designed for anyone travelling from Ushuaia to the Antarctic and who has even the slightest interest in wildlife."--Wildlife Extra "[D]efinitive identification guide... [E]asy-to-use... [O]ne-of-a kind guide... [M]ust-have guide for those visiting Antarctica!"--Guardian.co.uk "[T]akes a quite different approach from that of all previous guides to the area... [H]igh-quality photographic images, skillfully arranged... [F]or those with a general interest in natural history and wanting a small guide, the book succeeds admirably."--British Birds "This book joins a short list of good quality guides that concentrates on the Antarctic region... [H]undreds of superb illustrations... If you are headed far, far south, you will certainly want to have this attractive, informative, and handy book with you."--Avian Review "The book is a must for wildlife enthusiasts who are planning a trip to the southern tip of South America and the Antarctic. However, someone with an interest in this part of the world will find it a nice addition to their library."--FHB, Wildlife Activist "Those of us planning a trip to Antarctica will take this book along and turn to it first when an identification question arises. Those who have already been to Antarctica will wish this book had been with them."--Barbara Williams, IOS Wings Over the Prairie "For those who are contemplating that once-in-a-lifetime trip to the Antarctic, this book provides a handy photographic guide to the birds and mammals that you are likely to encounter... It will be invaluable on deck. It provides more than enough information to satisfy the general visitor, and would serve very well as a field guide for birders."--Birding World "I would ... recommend this book to travellers and experienced naturalists, as the information on the natural history of the area is very good."--Geoff Catpentier, Ontario Birding News "This is a well-done guide and an excellent purchase for academic and large public libraries."--Frederic F. Burchsted, American Reference Books Annual

    £16.19

  • Natural Beekeeping with the Warre Hive

    Northern Bee Books Natural Beekeeping with the Warre Hive

    10 in stock

    Book Synopsis

    10 in stock

    £13.25

  • Cannibalism: a Perfectly Natural History

    £18.04

  • Human Genetics ISE

    McGraw-Hill Education Human Genetics ISE

    Book SynopsisHuman Genetics: Concepts and Applications embraces the broadening of human genetics from an academic and medical discipline to an informational science that can be highly personal, yet have societal impact. By coming to know genetic backgrounds, people can control their environments in more healthy ways. Genetic knowledge is, therefore, both informative and empowering.Table of ContentsPart 1 Introduction1 The Information in a Human Genome2 Cells3 Meiosis, Development, and AgingPart 2 Transmission Genetics4 Single-Gene Inheritance5 Beyond Mendel’s Laws6 Matters of Sex7 Complex Traits8 Genetics of BehaviorPart 3 DNA and Chromosomes9 DNA Structure and Replication10 Gene Action: From DNA to Protein11 Gene Expression and Epigenetics12 Gene Mutation13 Chromosomes14 GenomesPart 4 Population Genetics15 Constant Allele Frequencies16 Changing Allele Frequencies17 Human Ancestry and Evolution18 The Genetics of IdentityPart 5 Immunity and Cancer19 Genetics of Immunity20 Cancer Genetics and GenomicsPart 6 Genetic Technology21 DNA and RNA Technologies22 Genetic Testing23 Reproductive Technologies

    £56.04

  • Exercised

    Random House USA Inc Exercised

    Out of stock

    Book SynopsisIf exercise is healthy (so good for you!), why do many people dislike or avoid it? These engaging stories and explanations will revolutionize the way you think about exercising—not to mention sitting, sleeping, sprinting, weight lifting, playing, fighting, walking, jogging, and even dancing.“Strikes a perfect balance of scholarship, wit, and enthusiasm.” —Bill Bryson, New York Times best-selling author of The Body• If we are born to walk and run, why do most of us take it easy whenever possible?• Does running ruin your knees?• Should we do weights, cardio, or high-intensity training?• Is sitting really the new smoking?• Can you lose weight by walking?• And how do we make sense of the conflicting, anxiety-inducing information about rest, physical activity, and exercise with which we are bombarded?In this myth-busting book, Daniel Lieberman, professor of human evo

    Out of stock

    £12.15

  • Behave: The Biology of Humans at Our Best and

    Penguin Putnam Inc Behave: The Biology of Humans at Our Best and

    5 in stock

    Book Synopsis

    5 in stock

    £30.60

  • The Theory of Ecological Communities

    Princeton University Press The Theory of Ecological Communities

    Book SynopsisA plethora of different theories, models, and concepts make up the field of community ecology. Amid this vast body of work, is it possible to build one general theory of ecological communities? What other scientific areas might serve as a guiding framework? As it turns out, the core focus of community ecologyunderstanding patterns of diversity and composition of biological variants across space and timeis shared by evolutionary biology and its very coherent conceptual framework, population genetics theory. The Theory of Ecological Communities takes this as a starting point to pull together community ecology''s various perspectives into a more unified whole.Mark Vellend builds a theory of ecological communities based on four overarching processes: selection among species, drift, dispersal, and speciation. These are analogues of the four central processes in population genetics theoryselection within species, drift, gene flow, and mutationand together they subsume almosTrade Review"In 1986, Thomas W. Schoener wrote a thought-provoking book chapter describing ecological communities along five organismal and five environmental axes. It was thought-provoking in the sense that Schoener attempted to unify community ecology using a minimal set of variables at a time when ecologists were doubtful of any unifying principle in community ecology. After three decades of Schoener's chapter, community ecologists are still divided about whether there could be a general theory of community. . . . Mark Vellend elegantly attempts to bridge this divide by introducing the theory of high-level processes in ecological communities in his Princeton Population Monograph entitled The Theory of Ecological Communities."---Madhav P. Thakur, Trends in Ecology and Evolution"Vellend (biology, Univ. de Sherbrooke, Canada) provides a useful historical account of the wide variety of methods used in the field to lay the foundation for his proposed resolution of the resulting ‘mess.' The book is well written, profusely referenced, and a worthy addition to the distinguished ‘Monographs in Population Biology’ series from Princeton University Press." * Choice *"Vellend does a tremendous job, and accomplishes for the field of community ecology what few have attempted, and even fewer, if any, have achieved. . . . With its overall plain language and clear prose, his book is excellent material for pre- and postgraduate students."---Lars Götzenberger and Jan Lepš, Conservation Biology"[Vellend] brings together diverse empirical and theoretical traditions in an unprecedented, engaging, and productive manner."---Max W. Dresow and Jake J. Grossman, Metascience"This is a very useful book for students and researchers."---Kevin S. McCann, Quarterly Review of Biology

    £31.50

  • How the Ocean Works

    Princeton University Press How the Ocean Works

    4 in stock

    Book SynopsisOffers a college-level introduction to marine science. This title explores early scientific knowledge of oceans, photosynthesis, trophic interactions and energy flow, and the impacts of human activities on marine and atmospheric systems. It includes color illustrations and informative diagrams.Trade ReviewHonorable Mention for the 2008 PROSE Award in Earth Sciences, Association of American Publishers "How the Ocean Works is as ambitious a title as this reviewer's freshman biology text, intimidatingly titled Life. However, much to his credit, Denny, not only acknowledges this fact, but manages to turn it to his advantage... How the Ocean Works is an invaluable addition to any undergraduate or graduate library where even a single marine-focused class is taught."--S.E. Brazer, Choice "The book is a very good read, well written, illustrated and explained, kept clear for a scientific layman, but also with necessary rigour in the Appendices associated with key chapters for those wanting that bit more physical or mathematical background."--Grant Bigg, The Geographical Journal "Steve Vogel describes Mark Denny as the ultimate autodidact, and teaching something, whether to oneself or to one's porch mates, is the ultimate learning approach and one that promises to produce a very readable introduction to oceanography. The book largely delivered on that promise and on my high expectations both Denny's preface and his prior works."--Quarterly Review of Biology "How the Ocean Works is a well written, thoroughly enjoyable book that comfortably bridges the roles of introductory oceanography textbook and fireside (or more appropriately, seaside) reading. Although its nontraditional coverage of ocean science may preclude it from use as the primary text in some classrooms, it will be a valuable resource for both teachers and fans of the world's oceans."--Peter Drzewiecki, American Biology Teacher "While explicitly designed as a textbook, How the Ocean Works is sure to be of interest to anyone looking for a deeper understanding of the bodies of water that cover 71 percent of the earth's surface and make up 99 percent of the volume of the planet that is capable of supporting life."--Civil Engineering "Denny gives readers the conceptual building blocks needed to develop a coherent picture of the living ocean. How the Ocean Works is an indispensable resource that teaches readers how to think about the ocean--its biology, mechanics, and conservation."--World Book IndustryTable of ContentsList of Illustrations ix List of Tables xiii Preface xv Chapter 1: Discovering the Oceans 1 Chapter 2: Ocean Basins 33 Chapter 3: Seawater 54 Chapter 4: Photosynthesis and Primary Production 68 Chapter 5: The Flow of Energy, Carbon, and Nutrients 106 Chapter 6: The Dilemma of the Two-Layered Ocean 145 Chapter 7: The Coriolis Effect and Its Consequences 173 Chapter 8: Winds and Currents 204 Chapter 9: Solutions to the Dilemma 233 Chapter 10: Complexity: Carbon, Iron, and the Atmosphere 251 Chapter 11: Fisheries 276 Chapter 12: An Invitation 299 Index 305

    4 in stock

    £63.00

  • Interdependence  Biology and Beyond

    Fordham University Press Interdependence Biology and Beyond

    Book SynopsisA coherent and practical philosophy of interdependence, drawing on vivid examples from the biological sciences.Trade Review"Kriti Sharma has written a remarkable book that moves seamlessly from the empirical world of biology-indeed, the microscales of test tubes and cells and molecules-to the consideration of the broadest philosophical concepts that define how we comprehend existence itself. The writing is lively and the illustrations are drawn from a wide and interdisciplinary range of sources and experiences, yet the development of the ideas is scholarly, careful, and well documented. Interdependence: Biology and Beyond will elevate and churn your thinking. It is Sharma's first book and the reader feels privileged to be present at the start of an exciting intellectual journey." -- -Peter White University of North Carolina at Chapel Hill "In setting forth her vision of contingentism-that objects are really webs of processes contingent on multiple interacting conditions-Sharma moves eloquently back and forth between biology and philosophy. The book is a model of accessible but serious and elegant science writing." -- -Evan Thompson University of British Columbia "It is a rare treat to indulge in reading a work that switches between philosophical reasoning and empirical biology. This is just what Sharma does, illuminating the concept of interdependence from its everyday usage to focus in on the micro-scale network of processes that are contingent on interactions of organisms with one another and their environments." -The Biologist "Interdependence is an exceptionally original work of comprehensive theorizing. Conceptually subtle, empirically rigorous, and compellingly argued, it addresses some of the most fundamental questions in theoretical biology and demonstrates their close relation to central problems in our ideas of knowledge, existence, and reality." -- -Barbara Herrnstein Smith author, Scandalous Knowledge: Science, Truth and the HumanTable of ContentsTable of Contents Introduction - Taking Interdependence Seriously A brief sketch of what's to come Chapter 1 - It Depends: Existence as Contingent Small worlds Introducing key concepts: reality, existence, and contingency Features of contingentism What contingentism is not Signal transduction and the book's organization Encouragement to stick with a challenging topic Chapter 2 - What Do Objects Depend On?: Physical Substance, Matter, and the External World Assumption of the intrinsic boundedness and continuity of objects Assumption of the intrinsic boundedness and continuity of particles Assumption of the intrinsic existence of (emergent) properties Assumption of the intrinsic existence of causal powers Assumption of the unified object of sense perceptions (both within and between observers) Assumption of non-impingement: "Whatever it is, it sure doesn't depend on us" Chapter summary Chapter 3 - What Does Sensing Depend On?: Transduction, Energy, and the Meeting of Worlds An overview of signal transduction Signal transduction and cell sensing Assumption of sameness and difference Assumption of energy as a kind of substance Relating physical and psychological phenomena Re-viewing sensing: new views of transformation and change Chapter summary Chapter 4 - What Do Organisms Depend On?: Bodies, Lives, Selves, and Internal Worlds Assumption of the boundedness and continuity of organisms Assumption of the coordinator and the experiencer Assumption of intrinsically existent "other minds": why do we take one another seriously as subjects? Assumption of a ground: physicalism, idealism, dualism, and contingentism What does your life depend on? Chapter summary Chapter 5 - What Does Order Depend On?: Patterns, Gaps, and the Known World On cognitive patterns and cognitive dissonance: what does order depend on? Assumption of the intrinsic existence of contradictions: what does surprise depend on? Assumption of intrinsic hierarchies of order: what makes a good theory? Assumption of a single origin and a linear history Assumption of knowledge as limited: exactly where are the gaps between organismal experience and reality? Chapter summary Conclusion - Life As We Know It "Nothing but net": thoroughgoing contingency and the absence of inherent existence Why "contingentism"?: genealogies, relations, and intellectual kindred The many forms that wonder takes Coda: Small, vast worlds Acknowledgments: What Does This Book Depend On? References

    £18.89

  • On the Backs of Tortoises Darwin the Galapagos

    Yale University Press On the Backs of Tortoises Darwin the Galapagos

    1 in stock

    Book SynopsisAn insightful exploration of the iconic Galápagos tortoises, and how their fate is inextricably linked to our own in a rapidly changing worldTrade ReviewFinalist for the 2020 E. O. Wilson Literary Science Writing Award, sponsored by PEN America Literary Awards“Wonderfully interesting, informative, and engaging, as well as scholarly.”—Janet Browne, author of Charles Darwin: Voyaging and Charles Darwin: The Power of Place“Timely, fresh, and compelling . . . a must-read for anyone interested in the environmental history of the Galapagos and tortoise conservation.”—Jamie Lorimer, University of Oxford, author of Wildlife in the Anthropocene: Conservation after Nature“Hennessy’s book isn’t just about the controversial efforts to preserve the world’s most famous tortoises—it also provides an expansive tour de force of Darwinian ideas, the Galapagos, human entanglements in evolution, and the risks of icon-making.”—Daniel Lewis, author of Belonging on an Island: Birds, Extinction, and Evolution in Hawai‘i“Hennessy’s enthralling history of the iconic Galápagos Islands focuses on the tortoises after which they are named to deftly unpack the contradictions of global conservation in the name of science.”—Claudia Leal, author of Landscapes of Freedom: Building a Postemancipation Society in the Rainforests of Western Colombia“Hennessy finds that even though this archipelago is 97 percent a national park, humans can no longer consider themselves distinct from nature, but rather are an inseparable part of it with consequences for the identity of each.”—Deborah Cramer, author of The Narrow Edge: A Tiny Bird, an Ancient Crab, and an Epic Journey

    1 in stock

    £21.38

  • Behave

    Penguin Putnam Inc Behave

    Out of stock

    Book Synopsis

    Out of stock

    £18.90

  • Body Am I The New Science of SelfConsciousness

    MIT Press Ltd Body Am I The New Science of SelfConsciousness

    1 in stock

    Book SynopsisHow the way we perceive our bodies plays a critical role in the way we perceive ourselves: stories of phantom limbs, rubber hands, anorexia, and other phenomena.The body is central to our sense of identity. It can be a canvas for self-expression, decorated with clothing, jewelry, cosmetics, tattoos, and piercings. But the body is more than that. Bodily awareness, says scientist-writer Moheb Costandi, is key to self-consciousness. In Body Am I, Costandi examines how the brain perceives the body, how that perception translates into our conscious experience of the body, and how that experience contributes to our sense of self. Along the way, he explores what can happen when the mechanisms of bodily awareness are disturbed, leading to such phenomena as phantom limbs, alien hands, and amputee fetishes. Costandi explains that the brain generates maps and models of the body that guide how we perceive and use it, and that these maps and models are repe

    1 in stock

    £19.50

  • Computing Skills for Biologists

    Princeton University Press Computing Skills for Biologists

    10 in stock

    Book SynopsisA concise introduction to key computing skills for biologistsWhile biological data continues to grow exponentially in size and quality, many of today's biologists are not trained adequately in the computing skills necessary for leveraging this information deluge. In Computing Skills for Biologists, Stefano Allesina and Madlen Wilmes present a valuable toolbox for the effective analysis of biological data. Based on the authors' experiences teaching scientific computing at the University of Chicago, this textbook emphasizes the automation of repetitive tasks and the construction of pipelines for data organization, analysis, visualization, and publication. Stressing practice rather than theory, the book's examples and exercises are drawn from actual biological data and solve cogent problems spanning the entire breadth of biological disciplines, including ecology, genetics, microbiology, and molecular biology. Beginners will benefit from the many examples explained step-by-step, while moTrade Review"Pitched perfectly for the beginning student and . . . a useful reference for the rest of us. . . . An excellent starting point for anyone about to step off into the world of computational biology."---Dr David Martin & Laura Pugh, The Biologist"The book’s raison d’etre is to provide an appetizer for efficient work at the computer. To do so. the authors cometently and engagingly outline the key advantage of each language for a specific task, introduce its working in a tutorial-like style, before illustrating the efficiency with a specific, yet typical task."---Carsten F. Dormann, Basic and Applied Ecology

    10 in stock

    £42.75

  • Spectroscopy

    John Wiley & Sons Inc Spectroscopy

    Book SynopsisProvides students and practitioners with a comprehensive understanding of the theory of spectroscopy and the design and use of spectrophotometers In this book, you will learn the fundamental principles underpinning molecular spectroscopy and the connections between those principles and the design of spectrophotometers. Spectroscopy, along with chromatography, mass spectrometry, and electrochemistry, is an important and widely-used analytical technique. Applications of spectroscopy include air quality monitoring, compound identification, and the analysis of paintings and culturally important artifacts. This book introduces students to the fundamentals of molecular spectroscopy including UV-visible, infrared, fluorescence, and Raman spectroscopy in an approachable and comprehensive way. It goes beyond the basics of the subject and provides a detailed look at the interplay between theory and practice, making it ideal for courses in quantitative analysis, instrumeTable of ContentsABOUT THE COVER ix PREFACE xi 1. Fundamentals of Spectroscopy 1 1.1 Properties of Electromagnetic Radiation 1 1.1.1 Speed, c 2 1.1.2 Amplitude, A 2 1.1.3 Frequency, υ 3 1.1.4 Wavelength, λ 3 1.1.5 Energy, E 3 1.1.6 Wavenumber, 6 1.2 The Electromagnetic Spectrum 7 1.2.1 Radio‐Frequency Radiation (10−27 to 10−21 J/photon) 8 1.2.2 Microwave Radiation (10−23 to 10−22 J/photon) 10 1.2.3 Infrared Radiation (10−22 to 10−19 J/photon) 11 1.2.4 Ultraviolet and Visible Radiation (10−19 to 10−18 J/photon) 12 1.2.5 X‐Ray Radiation (10−15 to 10−13 J/photon) 13 1.2.6 Alpha, Beta, and Gamma Radiation (10−13 to 10−11 J/photon and Higher) 13 1.3 The Perrin–Jablonski Diagram 15 1.3.1 Timescales of Events 18 1.3.2 Summary of Radiative and Nonradiative Processes 19 1.4 Temperature Effects on Ground and Excited State Populations 19 1.5 More Wave Characteristics 21 1.5.1 Adding Waves Together 21 1.5.2 Diffraction 21 1.5.3 Reflection 25 1.5.4 Refraction 28 1.5.5 Scattering 29 1.5.6 Polarized Radiation 31 1.6 Spectroscopy Applications 34 1.7 Summary 34 Problems 34 References 36 Further Reading 38 2. UV‐Visible Spectrophotometry 39 2.1 Theory 40 2.1.1 The Absorption Process 40 2.1.2 The Beer–Lambert Law 43 2.1.3 Solvent Effects on Molar Absorptivity and Spectra 49 2.2 UV‐Visible Instrumentation 52 2.2.1 Sources of Visible and Ultraviolet Light 54 2.2.2 Wavelength Selection: Filters 58 2.2.3 Wavelength Selection: Monochromators 61 2.2.4 Monochromator Designs: Putting It All Together 75 2.2.5 Detectors 79 2.3 Spectrophotometer Designs 85 2.3.1 Single‐Beam Spectrophotometers 85 2.3.2 Scanning Double‐Beam Instruments 89 2.3.3 Photodiode Array Instruments 93 2.4 The Practice of Spectrophotometry 98 2.4.1 Types of Samples That Can Be Analyzed 99 2.4.2 Preparation of Calibration Curves 100 2.4.3 Deviations from Beer’s Law 103 2.4.4 Precision: Relative Concentration Error 111 2.4.5 The Desirable Absorbance Range 114 2.5 Applications and Techniques 116 2.5.1 Simultaneous Determinations of Multicomponent Systems 116 2.5.2 Difference Spectroscopy 117 2.5.3 Derivative Spectroscopy 118 2.5.4 Titration Curves 119 2.5.5 Turbidimetry and Nephelometry 121 2.6 A Specific Application of UV‐Visible Spectroscopy: Enzyme Kinetics 122 2.6.1 Myeloperoxidase, Immune Responses, Heart Attacks,and Enzyme Kinetics 122 2.6.2 Possible Mechanism for Myeloperoxidase Oxidation of LDL via Tyrosyl Radical Intermediates 123 2.7 Summary 127 Problems 127 References 132 Further Reading 134 3. Molecular Luminescence: Fluorescence, Phosphorescence, and Chemiluminescence 135 3.1 Theory 135 3.1.1 Absorbance Compared to Fluorescence 136 3.1.2 Factors That Affect Fluorescence Intensity 141 3.1.3 Quenching 146 3.1.4 Quantum Yield and Fluorescence Intensity 147 3.1.5 Linearity and Nonlinearity of Fluorescence: Quenching and Self-Absorption 149 3.2 Instrumentation 153 3.2.1 Instrument Design 154 3.2.2 Sources 154 3.2.3 Filters and Monochromators 157 3.2.4 Component Arrangement 158 3.2.5 Fluorometers 158 3.2.6 Spectrofluorometers 159 3.2.7 Cells and Slit Widths 164 3.2.8 Detectors 166 3.3 Practice of Luminescence Spectroscopy 167 3.3.1 Considerations and Options 167 3.3.2 Fluorescence Polarization 168 3.3.3 Time‐Resolved Fluorescence Spectroscopy 172 3.4 Fluorescence Microscopy 173 3.4.1 Fluorescence Microscopy Resolution 175 3.4.2 Confocal Fluorescence Microscopy 175 3.5 Phosphorescence and Chemiluminescence 177 3.5.1 Phosphorescence 177 3.5.2 Chemiluminescence 177 3.6 Applications of Fluorescence: Biological Systems and DNA Sequencing 179 3.7 Summary 186 Problems 186 References 190 Further Reading 192 4. Infrared Spectroscopy 193 4.1 Theory 193 4.1.1 Bond Vibrations 196 4.1.2 Other Types of Vibrations 198 4.1.3 Modeling Vibrations: Harmonic and Nonharmonic Oscillators 200 4.1.4 The 3N−6 Rule 207 4.2 FTIR Instruments 209 4.2.1 The Michelson Interferometer and Fourier Transform 210 4.2.2 Components of FTIR Instruments: Sources 224 4.2.3 Components of FTIR Instruments: DTGS and MCT Detectors 226 4.2.4 Sample Handling 227 4.2.5 Reflectance Techniques 231 4.3 Applications of IR Spectroscopy, Including Near‐IR and Far‐IR 234 4.3.1 Structure Determination with Mid‐IR Spectroscopy 235 4.3.2 Gas Analysis 235 4.3.3 Near‐Infrared Spectroscopy (NIR) 236 4.3.4 Far‐Infrared Spectroscopy (FIR) 245 4.4 Summary 248 Problems 248 References 251 Further Reading 254 5. Raman Spectroscopy 255 5.1 Energy-Level Description 255 5.2 Visualization of Raman Data 258 5.3 Molecular Polarizability 259 5.4 Brief Review of Molecular Vibrations 261 5.5 Classical Theory of Raman Scattering 262 5.6 Polarization of Raman Scattering 265 5.6.1 Depolarization Ratio 266 5.7 Instrumentation and Analysis Methods 266 5.7.1 Filter Instruments 267 5.7.2 Dispersive Spectrometers 270 5.7.3 Fourier Transform Raman Spectrometers 271 5.7.4 Confocal Raman Instruments 271 5.7.5 Light Sources 273 5.8 Quantitative Analysis Methods 274 5.8.1 Calibration Curves 274 5.8.2 Curve Fitting 274 5.8.3 Ordinary Least Squares 275 5.8.4 Classical Least Squares 277 5.8.5 Implicit Analytical Methods 277 5.9 Applications 277 5.9.1 Art and Archeology 277 5.9.2 Pharmaceuticals 278 5.9.3 Forensics 279 5.9.4 Medicine and Biology 279 5.10 Signal Enhancement Techniques 282 5.10.1 Resonance Raman Spectroscopy 283 5.10.2 Surface-Enhanced Raman Spectroscopy 283 5.10.3 Nonlinear Raman Spectroscopy 284 5.11 Summary 286 Problems 286 References 288 Further Reading 289 SOLUTIONS 291 INDEX 315

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Marine sediments are important as habitats for life, in geochemical cycling elements, and as an essential record of the past. These themes are seamlessly integrated in the book, which should find a place on the shelves of anyone working in these areas."--Carol Arnosti, Limnology and Oceanography Bulletin "Burdige offers a thorough and complete discussion of geochemical processes governing sedimentary composition and diagenesis, according to the current understanding... The presentation is comprehensive and clear."--Choice "In this extraordinary tour de force, Burdige captures the complexity and growing interdisciplinary nature of the field of marine geochemistry. The book is sure to become a standard text for years to come."--Thomas S. Bianchi, EosTable of ContentsPreface xv Common Abbreviations and Symbols xvii CHAPTER ONE: Introduction 1 CHAPTER TWO: The Components of Marine Sediments 5 2.1 Detrital Components 5 2.2 Biogenic Components 8 2.2.1 Biogenic Carbonates 9 2.2.2 Biogenic Silica 10 2.2.3 Distribution of Biogenic Components in Marine Sediments 10 2.3 Authigenic Minerals 12 2.3.1 Nonbiogenic Carbonates 13 2.3.2 Mn Crusts, Layers, and Nodules 13 2.3.3 Phosphorites 14 2.3.4 Sulfides 15 2.4 Clays and Clay Minerals 15 2.4.1 Distribution of Clay Minerals in Surface Marine Sediments 18 2.4.2 Ion Exchange/Adsorption 20 2.5 The Classification of Marine Sediments and Sedimentary Regimes 24 CHAPTER THREE: Isotope Geochemistry 27 3.1 Introduction 27 3.2 Principles of Isotope Fractionation 28 3.2.1 Terminology 30 3.2.2 Equilibrium Isotope Exchange Reactions 31 3.3 Isotope Fractionation in Inorganic Materials in Nature 32 3.3.1 Isotope Fractionation in the Hydrosphere and in Ice Cores 32 3.3.2 Isotope Fractionation during Clay Mineral Formation 34 3.3.3 Oxygen and Carbon Isotopes in Calcite 35 3.4 Carbon Isotopes in Organic Matter 36 3.4.1 Photosynthesis 37 3.4.2 Respiration (Early Diagenesis in Sediments) 38 3.5 Oxygen and Carbon Isotopes in Sediment Pore-Waters 38 3.5.1 Carbon Isotopes 38 3.5.2 Oxygen Isotopes 39 3.6 Nitrogen Isotopes 39 3.7 Sulfur Isotopes 40 3.8 Radioactive Isotopes 40 3.8.1 Basic Principles 40 3.8.2 Radiocarbon 43 CHAPTER FOUR: Physical Properties of Sediments 46 4.1 Grain Size 46 4.2 Porosity and Sediment Density 47 4.3 Permeability 55 CHAPTER FIVE: An Introduction to Transport Processes in Sediments 59 5.1 Diffusion 59 5.2 Sediment Accumulation, Steady State,and the Frame of Reference for Processes in Marine Sediments 61 5.3 An Introduction to Bioturbation and Bioirrigation 65 5.4 Time and Space Scales of Sediment Processes 67 5.5 The Classification of Marine Sediments on the Basis of Their Functional Diagenetic Characteristics 70 CHAPTER SIX: Models of Sediment Diagenesis 72 6.1 The General Diagenetic Equation 72 6.1.1 Diffusion 74 6.1.2 Advection, Sediment Compaction, and Bioturbation 78 6.1.3 Adsorption 83 6.2 Solutions to the Diagenetic Equation 84 6.2.1 Boundary Conditions 86 6.3 Solutions to Specific Diagenetic Equations 87 6.3.1 Organic Matter Remineralization without Bioturbation 88 6.3.2 Organic Matter Remineralization with Bioturbation 89 6.3.3 Organic Matter Remineralization Coupled to Sulfate Reduction 91 6.3.4 Ammonium Production in Anoxic Sediments 92 6.3.5 Determination of Sediment Accumulation Rates 95 CHAPTER SEVEN Biogeochemical Processes in Sediments 97 7.1 Bacterial Metabolism: General Considerations 98 7.2 Bacterial Respiration and Biogeochemical Zonation in Sediments 99 7.3 Bacterial Respiration: Specific Processes 105 7.3.1 Aerobic Respiration 105 7.3.2 Denitrification 105 7.3.3 Manganese and Iron Reduction 107 7.3.4 Sulfate Reduction 110 7.3.5 Methanogenesis 111 7.4 Chemolithotrophic Reactions 114 7.4.1 Aerobic Processes 114 7.4.2 Anaerobic Processes 116 7.4.3 Linkages between Chemolithotrophic and Organic Matter Remineralization Processes 116 7.5 The Distribution of Organic Matter Remineralization Processes in Marine Sediments 120 7.5.1 Depth Scales of Biogeochemical Zonation 120 7.5.2 General Trends with Water Column Depth or Sediment Type 124 7.6 Dynamics of Organic Matter Decomposition in Sediments 134 7.6.1 General Considerations 134 7.6.2 Anaerobic "Foodchains" 135 7.6.3 Dynamics of Organic Matter Decomposition under Mixed Redox Conditions 139 CHAPTER EIGHT: Quantifying Carbon and Nutrient Remineralization in Sediments 142 8.1 Models of Organic Matter Decomposition in Sediments 142 8.2 Sediment Budgets for Reactive Components 150 8.2.1 Theoretical Considerations 151 8.2.2 Sediment Nutrient Budgets Using Cape Lookout Bight as an Example 153 8.3 Carbon Burial in Sediments 161 8.4 Layered and Coupled Models of Sediment Diagenesis 162 CHAPTER NINE: An Introduction to the Organic Geochemistry of Marine Sediments 171 9.1 General Considerations 172 9.2 Concentrations and Sources of Organic Matter in Marine Sediments 174 9.3 The Bulk Chemical Composition of Marine Sediment Organic Matter 175 9.4 Amino Acids 179 9.5 Carbohydrates 189 9.6 Lignins 193 9.7 Lipids 194 9.8 Humic Substances and Molecularly Uncharacterized Organic Matter 204 9.8.1 Black Carbon 206 9.8.2 Molecularly Uncharacterized Organic Matter (MU-OM): General Considerations 207 9.8.3 Geopolymerization: The Formation of Humic Substances 209 9.8.4 Selective Preservation of Refractory Biomacromolecules 212 9.8.5 Physical Protection 213 9.9 Organic Nitrogen Diagenesis in Sediments 215 CHAPTER TEN: Dissolved Organic Matter in Marine Sediments 218 10.1 General Observations 218 10.2 Diagenetic Models of Pore-Water DOM Cycling in Sediments 227 10.3 Pore-Water DOM Compositional Data 228 10.3.1 Short-Chain Organic Acids 230 10.3.2 Carbohydrates 231 10.3.3 Amino Acids 231 10.4 Fluxes of DOM from Marine Sediments 232 10.5 DOM Adsorption and Sediment-Organic Matter Interactions 234 CHAPTER ELEVEN: Linking Sediment Organic Geochemistry and Sediment Diagenesis 237 11.1 The Sources of Organic Matter to Marine Sediments 237 11.1.1 Carbon and Nitrogen Isotopic Tracers of Organic Matter Sources 238 11.1.2 Elemental Ratios as Tracers of Organic Matter Sources 241 11.1.3 Spatial Trends in the Sources of Organic Matter to Marine Sediments:Marine versus Terrestrial 244 11.1.4 Other Sources of Organic Matter to Marine Sediments: Black Carbon and Recycled Kerogen 249 11.1.5 Production of Bacterial Biomass in Sediments 250 11.2 The Composition of Organic Matter Undergoing Remineralization in Marine Sediments 253 11.2.1 Pore-Water Stoichiometric Models for Nutrient Regeneration/Organic Mater Remineralization 254 11.2.2 Benthic Flux and Sediment POM Stoichiometric Models for Nutrient Regeneration 260 11.2.3 The Composition of Organic Matter Undergoing Remineralization: Elemental Ratios and Stable Isotopic Composition 261 11.2.4 The Composition of Organic Matter Undergoing Remineralization: Organic Geochemical Composition 265 CHAPTER TWELVE: Processes at the Sediment-Water Interface 271 12.1 The Determination of Benthic Fluxes 272 12.2 Diffusive Transportand the Benthic Boundary Layer 274 12.3 Sediment-Water Exchange Processes in Permeable Sediments 283 12.4 Bioturbation 286 12.4.1 General Considerations 286 12.4.2 Models of Bioturbation 289 12.4.3 Nonlocal Sediment Mixing 299 12.5 Bioirrigation 302 12.5.1 The Diffusive Openness of Bioirrigated Sediments 313 12.5.2 Methods for Quantifying Bioirrigation in Sediments 316 12.5.3 Rates of Bioirrigation in Marine Sediments 319 12.6 Other Sediment-Water Interface Processes: Methane Gas Ebullition 326 CHAPTER THIRTEEN: Biogeochemical Processes in Pelagic (Deep-Sea) Sediments 328 13.1 Organic Matter Remineralization 328 13.2 Trace Metal Diagenesis 332 13.3 Manganese Nodules and Crusts 344 13.4 Diagenesis of Opaline Silica 352 13.5 Diagenesis of Calcium Carbonate 359 CHAPTER FOURTEEN: Nonsteady-State Processes in Marine Sediments 373 14.1 General Considerations 373 14.2 Periodic Input Processes 374 14.3 Seasonality in Sediment Processes 378 14.4 Diagenetic Processes in Deep-Sea Turbidites 382 14.4.1 Organic Geochemical Studies of Turbidite Diagenesis 391 14.5 Multiple Mn Peaks in Sediments: Nonsteady-State Diagenetic Processes Associated with Paleoceanographic Changes 395 14.5.1 Multiple Mn Peaks and the Glacial-Holocene Transition 400 14.5.2 Multiple Mn Peaks and Pleistocene Climate Cycles 402 14.5.3 Multiple Mn Peaks in Holocene Sediments 404 CHAPTER FIFTEEN: The Controls on Organic Carbon Preservation in Marine Sediments 408 15.1 Organic Matter-Mineral Interactions 412 15.2 The Role of Oxygen in Sediment Carbon Remineralization and Preservation 417 15.3 The Role of Benthic Macrofaunal Processes in Sediment Carbon Remineralization and Preservation 419 15.4 Oxygen Exposure Time as a Determinant of Organic Carbon Preservation in Sediments 421 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    Out of stock

    Book SynopsisGeneralized Estimating Equations, Second Edition updates the best-selling previous edition, which has been the standard text on the subject since it was published a decade ago. Combining theory and application, the text provides readers with a comprehensive discussion of GEE and related models. Numerous examples are employed throughout the text, along with the software code used to create, run, and evaluate the models being examined. Stata is used as the primary software for running and displaying modeling output; associated R code is also given to allow R users to replicate Stata examples. Specific examples of SAS usage are provided in the final chapter as well as on the book's website.This second edition incorporates comments and suggestions from a variety of sources, including the Statistics.com course on longitudinal and panel models taught by the authors. Other enhancements include an examination of GEE marginal effects; a more thorough presentatiTrade Review"Overall, I found this to be a very useful book on GEE, and would recommend it to anyone planning to use GEE models in their data analysis. Both the theory and practical aspects of constructing and analysing such models is covered. Inclusion of code for many of the analyses is an excellent feature."—Ken J. Beath, Macquarie University, Australia, Australian and New Zealand Journal of Statistics, April 2017" … the authors expand the text with several additions: (I) they examine and include entirely new topics related to GEE and the estimation of clustered and longitudinal models; (2) they add more detailed discussions of previously presented topics, including expanding the discussion of various models associated with GEE (penalized GEE, survey GEE, and quasi-least-square regression), adding material on hypothesis testing and diagnostics, and introducing alternative models for ordered categorical outcomes and an extension of the QIC, which is a model selection criterion measure; (3) they expand the amount of computer code by adding R code to duplicate the Stata examples wherever possible. In my opinion, the second edition is enhanced by the additions mentioned above, providing an excellent review of the GEE, wide coverage of its variations, and many useful computing techniques. I believe it would be a very useful reference book for practicing researchers and graduate students who are interested in research topics related to GEE."—CindyYu, Iowa State University in the Journal of the American Statistical Association, December 2013"The second edition … adds a few new topics related to various extensions of GEE … [and replaces] outdated S-PLUS codes with R scripts. Also, the number of exercises increased significantly … . For those who want to use this book in the classroom, including me, having extra exercise sets is certainly a welcome addition. … One main strength of this book is its comprehensive coverage of Stata implementation of the GEE. … a valuable reference and is particularly useful for practitioners. It can serve as supplemental reading in longitudinal data analysis classes as well."—Woncheol Jang, Biometrics, September 2013Praise for the First Edition:"… well-written chapters … . The book contains challenging problems in exercises and is suitable to be a textbook in a graduate-level course on estimating functions. The references are up-to-date and exhaustive. … I enjoyed reading [this book] and recommend [it] very highly to the statistical community."—Journal of Statistical Computation and Simulation, February 2005"[The book] is comprehensive and covers much useful material with formulas presented in detail … a useful and recommendable book both for those who already work with GEE methods and for newcomers to the field."—Per Kragh Andersen, University of Copenhagen, Statistics in Medicine, 2004"Generalized Estimating Equations is the first and only book to date dedicated exclusively to generalized estimating equations (GEE). I find it to be a good reference text for anyone using generalized linear models (GLIM).The authors do a good job of not only presenting the general theory of GEE models, but also giving explicit examples of various correlation structures, link functions and a comparison between population-averaged and subject-specific models. Furthermore, there are sections on the analysis of residuals, deletion diagnostics, goodness-of-fit criteria, and hypothesis testing. Good data-driven examples that give comparisons between different GEE models are provided throughout the book. Perhaps the greatest strength of this book is its completeness. It is a thorough compendium of information from the GEE literature. Overall, Generalized Estimating Equations contains a unique survey of GEE models in an attempt to unify notation and provide the most in-depth treatment of GEEs. I believe that it serves as a valuable reference for researchers, teachers, and students who study and practice GLIM methodology."—Journal of the American Statistics Association, March 2004"Generalized Estimating Equations is a good introductory book for analysing continuous and discrete data using GEE methods ... . This book is easy to read, and it assumes that the reader has some background in GLM. Many examples are drawn from biomedical studies and survey studies, and so it provides good guidance for analysing correlated data in these and other areas."—Technometrics, 2003"Overall, I found this to be a very useful book on GEE, and would recommend it to anyone planning to use GEE models in their data analysis. Both the theory and practical aspects of constructing and analysing such models is covered. Inclusion of code for many of the analyses is an excellent feature."—Ken J. Beath, Macquarie University, Australia, Australian and New Zealand Journal of Statistics, April 2017"The second edition … adds a few new topics related to various extensions of GEE … [and replaces] outdated S-PLUS codes with R scripts. Also, the number of exercises increased significantly … . For those who want to use this book in the classroom, including me, having extra exercise sets is certainly a welcome addition. … One main strength of this book is its comprehensive coverage of Stata implementation of the GEE. … a valuable reference and is particularly useful for practitioners. It can serve as supplemental reading in longitudinal data analysis classes as well."—Woncheol Jang, Biometrics, September 2013Praise for the First Edition:"… well-written chapters … . The book contains challenging problems in exercises and is suitable to be a textbook in a graduate-level course on estimating functions. The references are up-to-date and exhaustive. … I enjoyed reading [this book] and recommend [it] very highly to the statistical community."—Journal of Statistical Computation and Simulation, February 2005"[The book] is comprehensive and covers much useful material with formulas presented in detail … a useful and recommendable book both for those who already work with GEE methods and for newcomers to the field."—Per Kragh Andersen, University of Copenhagen, Statistics in Medicine, 2004"Generalized Estimating Equations is the first and only book to date dedicated exclusively to generalized estimating equations (GEE). I find it to be a good reference text for anyone using generalized linear models (GLIM).The authors do a good job of not only presenting the general theory of GEE models, but also giving explicit examples of various correlation structures, link functions and a comparison between population-averaged and subject-specific models. Furthermore, there are sections on the analysis of residuals, deletion diagnostics, goodness-of-fit criteria, and hypothesis testing. Good data-driven examples that give comparisons between different GEE models are provided throughout the book. Perhaps the greatest strength of this book is its completeness. It is a thorough compendium of information from the GEE literature. Overall, Generalized Estimating Equations contains a unique survey of GEE models in an attempt to unify notation and provide the most in-depth treatment of GEEs. I believe that it serves as a valuable reference for researchers, teachers, and students who study and practice GLIM methodology."—Journal of the American Statistics Association, March 2004"Generalized Estimating Equations is a good introductory book for analysing continuous and discrete data using GEE methods ... . This book is easy to read, and it assumes that the reader has some background in GLM. Many examples are drawn from biomedical studies and survey studies, and so it provides good guidance for analysing correlated data in these and other areas."—Technometrics, 2003Table of ContentsIntroduction. Model Construction and Estimating Equations. Generalized Estimating Equations. Residuals, Diagnostics, and Testing. Programs and Datasets. References. Author Index. Subject Index.

    Out of stock

    £92.14

  • Mammal Societies

    John Wiley and Sons Ltd Mammal Societies

    Book SynopsisThe book aims to integrate our understanding of mammalian societies into a novel synthesis that is relevant to behavioural ecologists, ecologists, and anthropologists.Trade Review"Mammal Societies is an authoritative and magnificently written synthesis of mammalian social behavior. As Tim Clutton-Brock states in the preface, his goal was to �. . .create an integrated account of mammalian societies. . .,� which he achieves with a seamless elegance honed through decades of long-term research on primates, ungulates, and carnivores. The book explains the fundamental theory underlying sociality, and then applies it to understand the diversity of mammalian behavior. Unlike previous syntheses that separate humans from non-human primates, and primates from non-primates, Clutton-Brock masterfully integrates his knowledge of these disparate literatures, and of behavioral diversity in general, to create a genuinely interesting and stimulating overview and synthesis of what we do and do not know about mammalian social behavioral diversity with implications for understanding ourselves.....Throughout, Clutton-Brock clearly deconstructs hypotheses and critically reviews both the logic and the data supporting them...Mammal Societies is a goldmine for graduate students and those establishing new studies about the adaptive value of sociality in any taxa. It would make an outstanding book to read in a graduate seminar and should be on the desk of any graduate student or academic interested in social behavior in any taxa...In summary, Mammal Societies is an intellectual tour de force that will become a citation classic and will set the stage for the next generation of studies on the adaptive value of sociality. Although not an easy read, it is a must read for anyone interested in the diversity of social behavior and its implications for population demography, and the evolution and maintenance of animal sociality..."(Journal of Wildlife Management-December 2016)Shortlisted for the British Ecological Society�s �Marsh Book of the Year Award 2017', which acknowledges the important role that books have on ecology and its development.Table of ContentsPreface, xi Acknowledgements, xiii 1 Social evolution, 1 1.1 Origins, 1 1.2 Sociality and mating systems, 11 1.3 Reproductive competition, 13 1.4 Mate choice, 17 1.5 Parental care, 20 1.6 Cooperation, 24 1.7 Loaded labels, 34 References, 35 2 Female sociality, 47 2.1 Introduction, 47 2.2 Contrasts in female sociality, 47 2.3 Benefits of grouping, 53 2.4 Costs of grouping, 60 2.5 Sociality and fitness, 63 2.6 Comparative sociality, 65 2.7 The distribution of female sociality, 78 2.8 Group coordination, 79 2.9 Consequences of female sociality, 80 3 Female dispersal and philopatry, 94 3.1 Introduction, 94 3.2 Variation in female philopatry and dispersal, 96 3.3 Benefits of philopatry, 102 3.4 Benefits of dispersing, 104 3.5 Species differences in female philopatry, 111 3.6 Social and ecological consequences of female philopatry, 113 References, 115 4 Female mating decisions, 123 4.1 Introduction, 123 4.2 Direct benefits of mate choice to females, 128 4.3 Genetic benefits of mate choice to females, 128 4.4 Female mating preferences, 130 Maturity, 130 4.5 Mate choice copying, 142 4.6 Partner number and post-copulatory mate choice, 142 4.7 Variation in mate choice and partner number, 145 4.8 Consequences of female mating preferences, 146 References, 147 5 Maternal care, 156 5.1 Introduction, 156 5.2 The evolution of maternal care, 156 5.3 Prenatal investment, 162 5.4 Maternal effects, 166 5.5 Lactation and infant care, 170 5.6 Post-weaning investment, 176 5.7 Investment strategies, 180 5.8 Relationships between siblings, 182 5.9 Parent–offspring conflict, 185 5.10 Consequences of maternal care, 187 References, 188 6 Social development, 196 6.1 Introduction, 196 6.2 Social learning, 197 6.3 Social development, 203 6.4 Play, 204 6.5 Social knowledge, 205 6.6 Individual differences and personality, 210 6.7 Traditions, 212 References, 219 7 Communication, 226 7.1 Introduction, 226 7.2 Types of signal, 230 7.3 Signalling in theory and practice, 250 References, 255 8 Competition between females, 263 8.1 Introduction, 263 8.2 Competitive tactics, 267 8.3 Social structure and competition, 273 8.4 Conflict proliferation and limitation, 282 8.5 Consequences of female competition, 285 9 Cooperation between females, 298 9.1 Introduction, 298 9.2 Cooperation in different contexts, 298 9.3 Cheating in theory and practice, 322 9.4 The evolution of cooperation, 323 9.5 Consequences of cooperation, 324 References, 326 10 Mating systems, 333 10.1 Introduction, 333 10.2 Social monogamy, 335 10.3 Polygynous systems, 339 10.4 Genetic mating systems, 359 10.5 Consequences of polygyny, 360 11 Association between males, 373 11.1 Introduction, 373 11.2 Contrasts in the formation and structure of male groups, 373 11.3 Costs of association to males, 379 11.4 Benefits of association to males, 380 11.5 Kinship, familiarity, cooperation and hostility, 384 11.6 The size of male associations, 386 11.7 Contrasts in reproductive skew, 389 11.8 Consequences of male association, 391 References, 395 12 Male dispersal and its consequences, 401 12.1 Introduction, 401 12.2 Variation in dispersal rates by males, 401 12.3 The costs and benefits of dispersal to males,409 12.4 Secondary dispersal by males, 412 12.5 Sex differences in philopatry, 414 12.6 Dispersal distance, 416 12.7 The social and ecological consequences of male dispersal, 418 References, 421 13 Reproductive competition among males, 427 13.1 Introduction, 427 13.2 The benefits and costs of fighting, 427 13.3 Assessment and the evolution of maledisplays, 434 13.4 Adaptive fighting tactics, 445 13.5 Benefits and costs of mate guarding, 445 13.6 Adaptive guarding tactics, 447 13.7 Alternative tactics, 452 13.8 Sperm competition, 453 13.9 Consequences of reproductive competition between males, 456 References, 458 14 Relationships between males in multi-male groups, 466 14.1 Introduction, 466 14.2 The development of dominance, 467 14.3 Dominance and breeding success, 470 14.4 Reproductive skew in multi-male groups, 474 14.5 Dominance, condition and survival, 476 14.6 Coalitions and alliances, 477 14.7 Market models and the dynamics of supportive relationships, 482 14.8 Punishment, retaliation and reconciliation,482 14.9 The consequences of male hierarchies, 484 References, 486 15 Males and females, 493 15.1 Introduction, 493 15.2 Male mate choice, 494 15.3 Manipulation, 496 15.4 Coercion, 496 15.5 Female counter-strategies to male coercion,507 15.6 Male infanticide, 508 15.7 Female counter-strategies to male infanticide, 516 15.8 Post-copulatory sexual conflict, 521 15.9 Demographic consequences of sexual conflict, 521 References, 524 16 Paternal care, 532 16.1 Introduction, 532 16.2 The distribution of paternal care, 533 16.3 Control mechanisms, 543 16.4 Benefits and costs of paternal care, 545 16.5 Tactical investment, 547 16.6 Conflicts between parents, 548 16.7 Male care and the evolution of mating systems, 548 References, 551 17 Cooperative breeding, 557 17.1 Introduction, 557 17.2 Delayed dispersal, 562 17.3 Reproductive suppression, 564 17.4 Reproductive skew, 570 17.5 Benefits and costs of helping, 574 17.6 Division of labour, 580 17.7 Regulation of workload, 584 17.8 The evolution of cooperative breeding, 586 17.9 Consequences of cooperative breeding, 589 References, 594 18 Sex differences, 605 18.1 Introduction, 605 18.2 Body size, 606 18.3 Weaponry, 608 18.4 Ornaments, 610 18.5 Growth, 610 18.6 Nursing, 615 18.7 Social development, 618 18.8 Feeding ecology, 621 18.9 Mortality, 623 18.10 Sex ratios at birth, 626 18.11 Adult sex ratios, 631 References, 633 19 Hominins and humans, 643 19.1 Introduction, 643 19.2 Human evolution, 644 19.3 Life histories, 649 19.4 Sex differences, 653 19.5 Hominin and human societies, 663 19.6 Why us?, 671 References, 673 20 Human behaviour, 680 20.1 Introduction, 680 20.2 Mate choice, 681 20.3 Parental care, 687 20.4 Allo-parental care, 693 20.5 Cooperation, 698 20.6 The human condition, 713 References, 714 Index, 725

    £48.40

  • Cytogenetic Abnormalities

    John Wiley and Sons Ltd Cytogenetic Abnormalities

    Book SynopsisCytogenetics is the study of the structure and function of chromosomes in relation to phenotypic expression.Chromosomal abnormalities underlie the development of a wide variety of diseases and disorders ranging from Down syndrome to cancer, and are of widespread interest in both basic and clinical research. Cytogenetic Abnormalities: Chromosomal, FISH, and Microarray-Based Clinical Reporting is a practical guide that describes cytogenetic abnormalities, their clinical implications and how best to report and communicate laboratory findings in research and clinical settings. The text first examines chromosomal, FISH, and microarray-based analyses in constitutional disorders. Using these same methodologies, the book''s focus shifts to acquired abnormalities in cancers. Both sections provide illustrative examples of cytogenetic abnormalities and how to communicate these findings in standardized laboratory reports. Providing both a wealth of cytogenetic information, as well Table of ContentsPreface xiv Acknowledgments xv About the companion website xvi Introduction 1 Part 1: Constitutional Analyses 5 Section 1: Chromosome Analysis 7 1 Components of a standard cytogenetics report, normal results and culture failures 9 1.1 Components of a standard cytogenetics report 9 1.2 Prenatal normal results 17 1.3 Neonatal normal results 22 1.4 Normal variants in the population 23 1.5 Disclaimers and recommendations 29 1.6 Culture failures 30 1.7 Contamination 32 2 Mosaicism 35 2.1 Normal results with 30–50 cells examined 37 2.2 Normal and abnormal cell lines 37 2.3 Two or more abnormal cell lines 39 3 Autosomal trisomies – prenatal and livebirths 41 3.1 Introduction 41 3.2 Trisomy 21 – Down syndrome 42 3.3 Mosaic trisomy 21 – mosaic Down syndrome 43 3.4 Trisomy 13 – Patau syndrome 44 3.5 Trisomy 18 – Edwards syndrome 45 3.6 Trisomy 8 – mosaic 46 3.7 Trisomy 9 – mosaic 47 3.8 Trisomy 20 – mosaic, prenatal 47 3.9 Trisomy 22 – mosaic, prenatal 48 4 Translocations 51 4.1 Reciprocal (balanced) translocations 51 4.2 Robertsonian translocations 58 5 Inversions and recombinant chromosomes 67 5.1 Risks of spontaneous abortions and liveborn abnormal offspring 67 5.2 Pericentric inversions and their recombinants 67 5.3 Paracentric inversions and their recombinants 71 6 Visible deletions, duplications and insertions 75 6.1 Definitions 75 6.2 Visible duplications 79 6.3 Balanced insertions 80 7 Unidentifiable marker chromosomes, derivative chromosomes, chromosomes with additional material and rings 85 7.1 Marker chromosomes 85 7.2 Derivative chromosomes 87 7.3 Chromosomes with additional material 90 7.4 Ring chromosomes 91 7.5 Homogenously staining regions 94 8 Isochromosomes, dicentric chromosomes and pseudodicentric chromosomes 97 8.1 Isochromosomes/dicentric chromosomes 97 8.2 Pseudodicentric chromosomes 104 9 Composite karyotypes and other complex rearrangements 107 9.1 Composite karyotypes 107 9.2 Complex rearrangements 109 10 Sex chromosome abnormalities 115 10.1 X chromosome aneuploidies – female phenotypes 115 10.2 X and Y chromosome aneuploidies – male phenotypes 120 10.3 X chromosome structural abnormalities 122 10.4 Y chromosome structural abnormalities 128 10.5 46,XX males and 46,XY females 132 10.6 X chromosome translocations 135 11 Fetal demises/spontaneous abortions 143 11.1 Aneuploid rate 143 11.2 Confined placental mosaicism 144 11.3 Hydatidiform moles 145 11.4 Monosomy X in a fetus 146 11.5 Trisomies in a fetus 146 11.6 Double trisomy 149 11.7 Triploidy 150 11.8 Tetraploidy 151 12 Uniparental disomy 155 12.1 Uniparental disomy of chromosome 14 157 12.2 Uniparental disomy of chromosome 15 158 12.3 Uniparental disomy of chromosome 11p15 159 Section 2: Fluorescence In Situ Hybridization (FISH) Analysis 161 13 Metaphase analysis 163 13.1 Introduction 163 13.2 Reporting normal results 164 13.3 Common disclaimers 166 13.4 Microdeletions 167 13.5 Microduplications 190 13.6 Fluorescence in situ hybridization for chromosome identification 198 13.7 Subtelomere fluorescence in situ hybridization analysis 200 14 Interphase analysis 205 14.1 Introduction 205 14.2 Example report of interphase analysis 206 14.3 Common disclaimers 207 14.4 Reporting normal results 208 14.5 Abnormal prenatal/neonatal results 211 14.6 Abnormal product of conception FISH abnormalities 218 14.7 Molar pregnancies 222 14.8 Preimplantation genetic diagnosis 222 15 Integrated chromosome and FISH analyses 231 15.1 ISCN rules and reporting normal results by chromosomes and FISH 232 15.2 ISCN rules and reporting abnormal chromosomes and FISH 233 15.3 ISCN rules and reporting of chromosomes and subtelomere FISH 237 Section 3: Chromosomal Microarray Analysis (CMA) 243 16 Bacterial artificial chromosome, oligoarray and single nucleotide polymorphism array methodologies for analysis 245 16.1 Introduction 245 16.2 Clinical utility of chromosomal microarray analysis 250 16.3 Guidelines for classification states 251 16.4 ISCN rules and reporting of normal results 252 16.5 Comments, disclaimers and recommendations 253 17 Microarray abnormal results 257 17.1 Reporting of abnormal results 257 17.2 Loss or gain of a single chromosome 258 17.3 Loss or gain of a whole chromosome complement 262 17.4 Microdeletions 263 17.5 Microduplications 265 17.6 Derivative chromosomes 267 17.7 Variants of unknown significance 269 17.8 Uniparental disomy/loss of heterozygosity/regions of homozygosity 269 17.9 Mosaicism 271 17.10 Common comments in abnormal reports 273 17.11 Microarrays with concurrent FISH studies and/or chromosome studies 274 17.12 Microarrays with concurrent parental studies 274 17.13 Preimplantation genetic diagnosis testing 275 17.14 Non-invasive prenatal testing 276 18 Pathogenic chromosomal microarray copy number changes by chromosome order 285 18.1 Chromosome 1 285 18.2 Chromosome 2 287 18.3 Chromosome 3 289 18.4 Chromosome 4 290 18.5 Chromosome 5 291 18.6 Chromosome 7 292 18.7 Chromosome 8 293 18.8 Chromosome 14 294 18.9 Chromosome 15 294 18.10 Chromosome 16 296 18.11 Chromosome 17 298 18.12 Chromosome 19 301 18.13 Chromosome 22 302 18.14 Chromosome X 306 19 Integrated reports with cytogenetics, FISH and microarrays 315 19.1 Reporting of a deletion 315 19.2 Reporting of a supernumerary chromosome 316 19.3 Reporting of an unbalanced translocation – deletion/duplication 318 19.4 Reporting of multiple abnormal cell lines 322 Part 2: Acquired Abnormalities in Hematological and Tumor Malignancies 325 Section 1: Chromosome Analysis 327 20 Introduction 329 20.1 Description of World Health Organization classification for hematological malignancies 332 20.2 Description of different tumor types with significant cytogenetic abnormalities 332 20.3 Set-up and analysis of specific cultures for optimal results 333 20.4 Nomenclature rules for normal and simple abnormal results 336 20.5 Common report comments for hematological malignancies 338 21 Results with constitutional or other non-neoplastic abnormalities 347 21.1 Possible constitutional abnormalities observed 347 21.2 Age-related abnormalities 349 21.3 Non-clonal aberrations 351 21.4 No growth and poor growth 354 22 Cytogenetic abnormalities in myeloid disorders 357 22.1 Introduction to myeloid disorders 357 22.2 Individual myeloid abnormalities by chromosome order 360 23 Cytogenetic abnormalities in lymphoid disorders 395 23.1 Introduction to lymphoid disorders 395 23.2 Hyperdiploidy and hypodiploidy 396 23.3 Individual lymphoid abnormalities by chromosome order 398 24 Common biphenotypic abnormalities and secondary changes 423 24.1 Translocation (4;11)(q21;q23) 423 24.2 Del(9q) 424 24.3 Translocation (11;19)(q23;p13.3) 424 24.4 Del(12)(p11.2p13) 425 24.5 Trisomy 15 425 24.6 i(17q) 426 25 Reporting complex abnormalities and multiple cell lines 429 25.1 Stemline and sideline abnormalities 430 25.2 Unrelated abnormal clones 434 25.3 Composite karyotypes 435 25.4 Double minute chromosomes 436 25.5 Modal ploidy numbers 438 25.6 Multiple abnormal cell lines indicative of clonal evolution 440 26 Breakage disorders 445 26.1 Ataxia telangiectasia 445 26.2 Bloom syndrome 446 26.3 Fanconi anemia 447 26.4 Nijmegen syndrome 448 27 Cytogenetic abnormalities in solid tumors 451 27.1 Clear cell sarcoma 451 27.2 Chondrosarcoma 452 27.3 Ewing sarcoma 453 27.4 Liposarcoma 453 27.5 Neuroblastoma 454 27.6 Rhabdomyosarcoma 455 27.7 Synovial sarcoma 456 27.8 Wilms tumor 456 Section 2: Fluorescence In Situ Hybridization (FISH) Analysis 459 28 Introduction to FISH analysis for hematological disorders and solid tumors 461 28.1 General results 462 28.2 Bone marrow transplantation results 468 29 Recurrent FISH abnormalities in myeloid disorders 471 29.1 Individual abnormalities in myeloid disorders by chromosome order 471 29.2 Biphenotypic and therapy-related abnormalities 491 29.3 Panels of probes 492 30 Recurrent FISH abnormalities in lymphoid disorders 499 30.1 Individual abnormalities in lymphoid disorders by chromosome order 499 30.2 Panels of probes 520 31 Integrated reports with cytogenetics and FISH in hematological malignancies 531 31.1 Translocation (9;22) with BCR/ABL1 FISH analysis 531 31.2 Monosomy 7 with a marker chromosome and chromosome 7 FISH analysis 532 31.3 Complex abnormalities with the MDS FISH panel 532 31.4 Complex abnormalities with ALL FISH panel 533 31.5 Complex abnormalities with MM FISH panel 535 31.6 Complex abnormalities with AML FISH panel 536 31.7 Complex abnormalities with AML FISH panel in therapy-related disease 537 32 Recurrent FISH abnormalities in solid tumors using paraffin-embedded tissue 541 32.1 Ewing sarcoma 544 32.2 Liposarcoma 545 32.3 Neuroblastoma 546 32.4 Non-small cell lung cancer 547 32.5 Oligodendroglioma 552 32.6 Rhabdomyosarcoma 554 32.7 Synovial sarcoma 554 33 Breast cancer – HER2 FISH analysis 559 33.1 Common report comments 560 33.2 Example HER2 reports 561 33.3 Genetic heterogeneity 563 34 Bladder cancer FISH analysis 569 34.1 Common report comments 570 34.2 Example reports 570 Section 3: Chromosomal Microarray Analysis (CMA) 577 35 Chromosomal microarray analysis for hematological disorders 579 35.1 Introduction 579 35.2 Categories of abnormalities 580 35.3 Complex abnormalities throughout the genome, chromothripsis and homozygosity 581 35.4 Normal results and disclaimers 582 35.5 Example abnormal results in hematological malignancies 583 36 Chromosomal microarrays for tumors 595 36.1 Introduction and disclaimers 595 36.2 Breast cancer 596 36.3 Lung cancer 604 36.4 Colon cancer 606 36.5 Prostate cancer 607 36.6 Unspecified tumor present 607 37 Integrated reports with chromosomes, FISH and microarrays 611 37.1 Homozygous deletion of 9p21 identified by FISH and CMA 611 37.2 Identifying marker chromosomes by chromosome analysis, FISH and CMA 612 37.3 Unbalanced translocation identification by chromosomes, FISH and CMA 614 Appendix 1: Example assay-specific reagent (ASR) FISH validation plan for constitutional disorders and hematological malignancies on fresh tissue 617 Glossary 623 Index 641

    £100.76

  • A Naturalists Guide to the Arctic

    The University of Chicago Press A Naturalists Guide to the Arctic

    Book SynopsisThis is a practical guide to the Arctic's natural history - sky, atmosphere, terrain, ice, the sea, plants, birds, mammals, fish and insects - for those who will experience the Arctic firsthand and also for armchair travellers.

    £19.95

  • Firefly Books Anatomy of Core Stability: A Trainer's Guide to

    Out of stock

    Book Synopsis

    Out of stock

    £999.99

  • Introducing Proteomics

    John Wiley & Sons Inc Introducing Proteomics

    Book Synopsis*Contemporary, Broad Coverage covers every aspect of the rapidly changing field of proteomics from *Coherent and Student friendly based on the highly successful course developed by the author at Manchester University.Table of ContentsPreface ix Acknowledgements xi 1 Introduction 1 1.1 What Are the Tasks in Proteomics? 1 1.2 Challenges in Proteomics 5 1.3 Proteomics in Relation to Other -omics and System Biology 10 1.4 Some General Applications of Proteomics 12 1.5 Structure of the Book 18 References 18 2 Separation and Detection Technologies 21 2.1 Introduction to Experimental Strategies in Proteomics 21 2.2 Gel-Based Separation 31 2.3 Visualization and Analysis of Proteins/Peptides in Gels 40 2.4 Gel-Free Separation Technologies 54 2.5 Visualization of Proteins/Peptides from Hyphenated Methods 74 2.6 Chips in Proteomic Applications 81 References 81 3 Analysis of Peptides/Proteins by Mass Spectrometry 83 3.1 Basic Principles of Mass Spectrometry for Proteomics 83 3.2 Ionization Methods for Small Amounts of Biomolecules 101 3.3 Mass Analyzers and Mass Spectrometers 116 3.4 Concluding Remarks on Mass Analyzers for Proteomics 170 References 170 4 Analysis and Interpretation of Mass Spectrometric and Proteomic Data 173 4.1 Introduction 173 4.2 Analysis of MS Data 174 4.3 Analysis of MS/MS Data 192 4.4 Quantification of LC MS and MS/MS Data from Complex Samples 209 4.5 Bioinformatic Approaches for Mass Spectrometric Proteome Data Analysis 213 References 218 5 Strategies in Proteomics 221 5.1 Imaging Mass Spectrometry 221 5.2 Qualitative Proteomics 223 5.3 Differential and Quantitative Proteomics 234 5.4 Analysis of Posttranslational Modifications 257 5.5 Interaction Proteomics 261 5.6 Proteomics as Part of Integrated Approaches 266 References 271 Index 275

    £38.90

  • A Different Kind of Animal

    Princeton University Press A Different Kind of Animal

    1 in stock

    Book SynopsisTrade Review"Boyd is at his best when he explains how norm construction occurs and how cultural transmission of complicated information can spread throughout a group. The work is thought-provoking." * Publishers Weekly *"In this lucid, well-argued treatise, anthropologist Robert Boyd avers that we are 'culture-saturated creatures', and that it is culturally transmitted knowledge that sets us apart and explains our dramatic range of behaviours, from rampant violence to great feats of cooperation."---Barbara Kiser, Nature"A Different Kind of Animal is a fascinating introduction to a fertile field of cultural research that should be better-known. Approachable and clearly argued, it is a brave revival of the autonomy of culture and a breath of fresh air for those tired of the narrow claims of evolutionary psychology." * Cosmos *"Boyd’s latest book is a clear exposition of his cultural evolutionary view of human evolution."---Thomas J.H. Morgan, Evolutionary Studies in Imaginative Culture

    1 in stock

    £19.80

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